CN105560475A - Traditional Chinese medicine composition for preventing chemical liver injury and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing chemical liver injury and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing chemical liver injury and a preparation method thereof. The composition is prepared from, by weight, 500-1000g of radix puerariae, 500-1000g of raisin tree seed, 500-1000g of pueraria flower, 500-1000g of wolfiporia cocos, 250-500g of rose and 250-500g of hawthorn leaves. The preparation processed from the several kinds of Chinese herbs via extraction and suitable preparations can effectively prevent and assist in protecting against chemical liver injury so as to achieve the effect of protecting the liver. The invention further provides a preparation method of the composition.
Description
Technical field
The invention belongs to modernization of Chinese medicine technical field, relate to a kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof.
Background technology
The hepatic injury of human body caused by chemical Hepatoxic substance mostly.Chemical liver injury mainly come from exist in the Nature, human industry's production process some to the hepatic injury caused by the harmful chemical of poisonous material, food, medicine and the heavy drinking etc. of liver.In daily life, drinking is that everybody gets together together, congratulates indispensable custom.But excessive drinking often causes hepatic injury.
Ethanol carries out metabolism at liver, and long-term heavy drinking can cause liver function rising, fatty liver, liver cirrhosis, hepatocarcinoma, massive hemorrhage etc.Alcoholic cirrhosis and normal liver, in alcoholic cirrhosis the normal structure of liver replace by fibrosed tissue, and function also goes down, and this infringement is eternal property.Ethanol also can damage nervous system, peripheral nerve inflammation is called to the damage of peripheral nervous system, show as numb limbs and tense tendons, unable on foot, to the damage of central nervous system, mainly to the damage of brain, show as hypomnesis, dementia, normal brain activity and Alcoholic cerebral lesion, this infringement is also irreversible.Drink and not only damage liver, also can damage other internal organs.Excessive drinking can cause dyspepsia, gastritis, gastrorrhagia, pancreatic necrosis, coronary heart disease, hypertension, cerebral thrombosis, cerebral hemorrhage, short term memory is lost, dull-witted, peripheral nerve is scorching.
Theory of Chinese medical science thinks that chemical poisonous substance, hepatotoxic medication or excessive wine belong to Shi Re Bing Pian.Poison heresy is the Fundamentals that primary disease causes a disease, and disease located in liver, relates to taste, and disease is from the beginning of mostly being excess syndrome, heat syndrome, and sick is then simulataneous insufficiency and excessive for a long time.The traditional Chinese medical science has abundant clinical experience from ancient times to the present in the hepatic injury that causes for the treatment of insobriety, with the clinical research of TCM prevention and cure chemical liver injury with experimentation document also more report.
Chinese medicine composition in a kind of Chinese medicine composition of preventing chemical liver injury of patent of the present invention and preparation method thereof is made up of Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Flos puerariae lobatae, Poria, Flos Rosae Rugosae, Folium Crataegi six medicaments.Radix Puerariae in side, Semen Hoveniae (Fructus Hoveniae), Flos puerariae lobatae are originally the medicines of traditional Antialcoholic liver-protecting.Radix Puerariae has expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, the effects such as alcoholic intoxication, and in the present invention, through extracting, the Radix Puerariae flavone in extract is widely used in health food for facilitating alcohol metabolism and protecting liver; Semen Hoveniae (Fructus Hoveniae) has relieving restlessness of quenching the thirst, clearing away damp-heat, alcoholic intoxication function, for middle alcoholism, and excessive thirst vomiting, the diseases such as difficulty in urination and defecation; Under " Treatise on the spleen and stomach " volume, under " interior wound is distinguished " volume, " Prescriptions for Universal Relief " roll up one seven two to draw " the raw hall side of moral " all the side of carrying Flos puerariae lobatae to neutralize the effect of alcoholic drinks soup, though all medicines are different in different ancient books and records side, Flos puerariae lobatae is the effect of relieving acute alcoholism and recuperating the spleen in all sides.Poria promoting diuresis with drugs of tasteless flavour in Chinese medicine composition of the present invention, makes the wet heresy of wine go out from urine; Flos Rosae Rugosae promoting QI circulation for relieving depression, for stomachache due to hyperactive liver-QI attacking the stomach, promote that enzyme is to the decomposition of ethanol and conversion; Folium Crataegi blood circulation promoting and blood stasis dispelling, regulates the flow of vital energy and promotes blood circulation, and changes turbid blood fat reducing.For the qi depression to blood stasis that insobriety causes, obstruction of qi in the chest and cardialgia, chest distress, palpitation and amnesia, vertigo and tinnitus etc.Compositions prepared by the method for patent of the present invention has protection hepatocyte, reduces hepatic injury, lipoid peroxidization resistant.When insobriety, the protection hepatocyte effect of tool, can prevent the chemical liver injury caused by ethanol effectively.
Summary of the invention
The invention discloses a kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof, it is characterized in that it is made up of the Chinese crude drug of following weight:
Radix Puerariae 500-1000g
Semen Hoveniae (Fructus Hoveniae) 500-1000g
Flos puerariae lobatae 500-1000g
Poria 500-1000g
Flos Rosae Rugosae 250-500g
Folium Crataegi 250-500g.
Preferably, in above-mentioned composition, each composition proportion is Radix Puerariae 600g, Semen Hoveniae (Fructus Hoveniae) 600g, Flos puerariae lobatae 600g, Poria 600g, Flos Rosae Rugosae 300g, Folium Crataegi 300g.
In order to use above-mentioned compositions more easily, the various Chinese medicines in compositions are according to the processing of Modern Pharmaceutics preparation process, and being prepared into oral formulations, namely can be one or more preparations in tablet, capsule, granule, oral liquid.Through modernization processing, compositions can play its effect better; Conveniently preserve, carry and use.
A kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof, its preparation method is undertaken by following step:
(1) get Flos puerariae lobatae, Flos Rosae Rugosae, Folium Crataegi, after weighing in proportion, be crushed to 10-20 order together, add 10 times of 50%-80% and measure ethanol stirring extraction twice (55 ~ 60 DEG C), each 2 hours; Filter, merging filtrate, reclaim ethanol and become viscous brownish to extractum; Extractum is dried to dry extract in microwave vacuum dryer, is crushed to 80-100 order, for subsequent use;
(2) get Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Poria, be crushed to 10-20 order together, add 8 ~ 10 times amount soak by water 3 times, each 1.5 ~ 2 hours after weighing in proportion, filter, merging filtrate, filtrate concentrates to obtain dry extract through heating in vacuum; Be crushed to 80-100 order, for subsequent use;
(3) by the compositions that the dry extract of preparation in (1) and (2) is mixed, the acceptable adjuvant of pharmaceutics is added, through the processing of specialty, acceptable dosage form when making application.As one or more preparations in tablet, capsule, granule, oral liquid.
Need to be illustrated especially: those skilled in the art can directly buy Chinese crude drug in the present composition according to content of the present invention or their extract prepares the preparation similar with patented composition of the present invention, tablet as described in the present invention, capsule, granule, oral liquid.Also pill, soft extract etc. can be made according to pharmacy preparation method, to this also within protection scope of the present invention.Preferably, the compositions described in invention refers to oral formulations.Comprise pill, tablet, capsule, granule; Obtained compositions all can be able to be taken before drinking, after drinking, to play the effect of its protection hepatocyte from damage.
Detailed description of the invention
Below in conjunction with embodiment, the preferred embodiment of the invention is described.
Embodiment 1
A kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof, compositions is made up of the Chinese crude drug of following weight: Radix Puerariae 600g, Semen Hoveniae (Fructus Hoveniae) 600g, Flos puerariae lobatae 600g, Poria 600g, Flos Rosae Rugosae 300g, Folium Crataegi 300g.Its preparation method is undertaken by following step:
(1) get Flos puerariae lobatae, Flos Rosae Rugosae, Folium Crataegi, after weighing by proportioning, be crushed to 10 orders together, add 15 liter of 75% ethanol and stir extraction twice (maintaining the temperature at 55 ~ 60 DEG C), each 2 hours; Filter, merging filtrate, reclaim ethanol and become viscous brownish to extractum; Extractum is dried to dry extract in microwave vacuum dryer, is crushed to 100 orders, for subsequent use;
(2) get Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Poria, be crushed to 10 orders together, add 20 premium on currency and decoct 3 times, each 2 hours after weighing in proportion, filter, merging filtrate, filtrate concentrates to obtain dry extract through heating in vacuum; Be crushed to 100 orders, for subsequent use;
(3) by the mixing of the dry extract of preparation in (1) and (2), the appropriate amount of auxiliary materials such as microcrystalline Cellulose, lactose, sucrose, mannitol, starch are added according to the preparation method of pharmaceutics tablet, through granulation, drying, granulate, add magnesium stearate always mixed, tabletting, make 1000, tablet altogether.
Embodiment 2
A kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof, compositions is made up of the Chinese crude drug of following weight: Radix Puerariae 600g, Semen Hoveniae (Fructus Hoveniae) 600g, Flos puerariae lobatae 600g, Poria 500g, Flos Rosae Rugosae 400g, Folium Crataegi 300g.Its preparation method is undertaken by following step:
(1) get Flos puerariae lobatae, Flos Rosae Rugosae, Folium Crataegi, after weighing by proportioning, be crushed to 10 orders together, add 16 liter of 70% ethanol and stir extraction twice (maintaining the temperature at 55 ~ 60 DEG C), each 2 hours; Filter, merging filtrate, reclaim ethanol and become viscous brownish to extractum; Extractum is dried to dry extract in microwave vacuum dryer, is crushed to 100 orders, for subsequent use;
(2) get Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Poria, be crushed to 10 orders together, add 20 premium on currency and decoct 3 times, each 2 hours after weighing in proportion, filter, merging filtrate, filtrate concentrates to obtain dry extract through heating in vacuum; Be crushed to 100 orders, for subsequent use;
(3) by the mixing of the dry extract of preparation in (1) and (2), add the appropriate amount of auxiliary materials such as sucrose, glucose, starch according to the preparation method of pharmaceutics granule, through granulations, drying, granulate, sieve, always mix, quantitative inner packing, make granule 300 bags altogether.
Above-mentioned detailed description of this kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; therefore in the change do not departed under general plotting of the present invention and amendment; the no matter quantitative change of each composition, the adjustment of processing technique, all belong within protection scope of the present invention.
Claims (5)
1. Chinese medicine composition of preventing chemical liver injury and preparation method thereof, is characterized in that, compositions is made up of the Chinese crude drug of following weight:
Radix Puerariae 500-1000g
Semen Hoveniae (Fructus Hoveniae) 500-1000g
Flos puerariae lobatae 500-1000g
Poria 500-1000g
Flos Rosae Rugosae 250-500g
Folium Crataegi 250-500g.
2. according to claim 1, a kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof, it is characterized in that, preferably, in compositions, each composition proportion is Radix Puerariae 600g, Semen Hoveniae (Fructus Hoveniae) 600g, Flos puerariae lobatae 600g, Poria 600g, Flos Rosae Rugosae 300g, Folium Crataegi 300g.
3. according to claim 1, a kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof, is characterized in that, compositions wherein refers to oral formulations, namely can be one or more preparations in tablet, capsule, granule, oral liquid.
4. according to claim 1, a kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof, is characterized in that, its preparation method is undertaken by following step:
(1) get Flos puerariae lobatae, Flos Rosae Rugosae, Folium Crataegi, after weighing in proportion, be crushed to 10-20 order together, add 10 times of 50%-80% and measure ethanol stirring extraction twice (55 ~ 60 DEG C), each 2 hours; Filter, merging filtrate, reclaim ethanol and become viscous brownish to extractum; Extractum is dried to dry extract in microwave vacuum dryer, is crushed to 80-100 order, for subsequent use;
(2) get Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Poria, be crushed to 10-20 order together, add 8 ~ 10 times amount soak by water 3 times, each 1.5 ~ 2 hours after weighing in proportion, filter, merging filtrate, filtrate concentrates to obtain dry extract through heating in vacuum; Be crushed to 80-100 order, for subsequent use;
(3) by the compositions that the dry extract of preparation in (1) and (2) is mixed, the acceptable adjuvant of pharmaceutics is added, through the processing of specialty, acceptable dosage form when making application; Described dosage form can be one or more preparations in tablet, capsule, granule, oral liquid.
5. according to claim 1, a kind of Chinese medicine composition of preventing chemical liver injury and preparation method thereof, is characterized in that, the application of described Chinese medicine composition in preparation prevention chemical liver injury medicine, food.
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| CN201510961271.8A CN105560475A (en) | 2015-12-21 | 2015-12-21 | Traditional Chinese medicine composition for preventing chemical liver injury and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524921A (en) * | 2018-03-30 | 2018-09-14 | 广西中医药大学 | A kind of antiradiation injury protective agent and its preparation method and application |
| CN109258908A (en) * | 2018-10-31 | 2019-01-25 | 方林 | A kind of preparation method of rose chewing gum |
| CN111821343A (en) * | 2020-08-24 | 2020-10-27 | 中国科学院新疆理化技术研究所 | Traditional Chinese medicine compound preparation for preventing and treating alcoholic liver injury and preparation method and application thereof |
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2015
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524921A (en) * | 2018-03-30 | 2018-09-14 | 广西中医药大学 | A kind of antiradiation injury protective agent and its preparation method and application |
| CN109258908A (en) * | 2018-10-31 | 2019-01-25 | 方林 | A kind of preparation method of rose chewing gum |
| CN111821343A (en) * | 2020-08-24 | 2020-10-27 | 中国科学院新疆理化技术研究所 | Traditional Chinese medicine compound preparation for preventing and treating alcoholic liver injury and preparation method and application thereof |
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