KR101093006B1 - Method for producing functional health food containing bezoar bovis used microbes and the functional health food produced by the same - Google Patents

Abstract

The present invention relates to a method for preparing healthy food containing sulfur sulfur Cheongshimwon raw materials using microorganisms and to health foods prepared by the manufacturing method. The active ingredient of sulfur sulfur cheongsimwon effective in the back is quickly absorbed and delivered to the human body has the advantage of very excellent absorption rate.

Raw materials, such as food, drinks, granulated tea, gel health foods and confectionery, through the process of condensation, granulation, fluidized bed drying, and powdering using fermented extracts or fermented powders which have undergone fermentation by adding microorganisms to the raw sulfur sulfur raw material Can also be used as

Sulfur Cheongsimwon, Microorganism, Fermentation, Health Food, Vacuum Low Temperature Extraction

Description

Method for producing functional health food containing bezoar bovis used microbes and the functional health food produced by the same}

The present invention adds a fermentation process using microorganisms to the sulfur sulfur cheongsimwon raw medicinal ingredients, the active ingredient of sulfur sulfur cheongsimwon effective in urgent patients or strokes and strokes is quickly absorbed and delivered to the human body containing sulfur sulfur cheongsimwon raw material using microorganisms with excellent absorption rate It relates to a method for producing a health food and a health food produced by the production method.

According to Korea's consent, gambangpyeon, medicinal intoxication, Wu Hwang Cheongsimwon is a stroke, forgetting well, surprised well, not clear mind, often surprised, stuffy heart, open face, sleepless, It is effective in epilepsy, stroke, hemorrhage of stroke, restraint of stroke, thrombosis, hysteria, and especially in the synonym dictionary. As described above, Woo Hwang Cheong-Shim Won has been commonly used in urgent patients as the best medicine of various Chinese medicine prescriptions, and is a prescription that has been treated especially with stroke and stroke.

Such sulfur sulfur cheongsimwon has been widely used for a long time as a herbal medicine, composed of about 24 kinds of herbal medicines other than white ginseng, and has been prepared by making a ring with honey and then making a ring with gold leaf. These dog treats require a certain amount of effect during the stay of the drug in the mouth, so if swallowed by swallowing, the effect is not properly obtained. Therefore, Woo Hwang Cheongsimwon is prescribed in the form of a pill form chewed in the mouth.

And now, the formulation of the sulfur sulfur cheongsimwon can be divided into pill and liquid, in the case of pills, the effect of the pill is slow to the liquid, but the duration is longer than the liquid. However, not only is inconvenient to carry, but the patient must chew and take it, so it is difficult to take it in an emergency such as a person's discomfort. Therefore, the improvement of the problems of these pills and the loss and stability of the active ingredients that occur when changing the form of the formulation has been developed a form of a liquid easy to take the drug, in the case of the liquid is easy to absorb, absorbed into the body The faster the effect is, the shorter the advantage is.

In particular, Woowang Cheongsimwon is widely used even in emergency situations such as stroke, arteriosclerosis, hypertension, palpitations, dyspnea, mental anxiety, angina pectoris, acute gusts, autonomic ataxia, and inability to respond to the dosage form. Absorption rate in the body has emerged as an important problem because the absorption should be rapid to speed up the drug expression.

Looking at the conventional methods for manufacturing such sulfur sulfur cheongsimwon as described above, the domestic registration patent publication No. 10-0569673 (August 11, 2006) when taking the sulfur sulfur cheongsimwon suspension of foreign matters, can be effective in a short time In order to prepare a new sulfur-free Cheongsimwon suspension by sugar acupuncture method to extract the herbal raw materials using sugar solution so as to prepare a suspension, it was found that it is not absorbed within a short time of the human body and the absorption rate is low.

In addition, Korean Patent Publication No. 1996-0015140 (notified on Nov. 1, 1996) includes extracts powdered from Uhwang Cheong-Shimwon herbal medicines, and the inclusions of cedar, musk, and sulfur powder, and other pharmaceutically acceptable carriers. In addition, there is disclosed a purified sulfur sulfur cheongsimwon and a method for producing the same by tableting and coating the composition, the ultrasonic extraction process, the enzyme treatment step of the extract obtained by this method, the enzyme inactivation and this enzyme treatment A series of manufacturing processes, such as freeze-drying or spray-drying the liquid in a general manner, have complicated disadvantages.

Therefore, the present invention for solving the above problems is the active ingredient of the sulfur sulfur cheongsimwon effective in urgent patients or stroke and stroke by adding a fermentation process using microorganisms to the existing manufacturing method for manufacturing sulfur sulfur cheongsimwon quickly It is an object of the present invention to provide a method for preparing healthy food containing sulfur sulfur Cheongshimwon raw material using microorganisms having excellent absorption rate so as to be absorbed and delivered, and a health food prepared by the manufacturing method.

Raw materials, such as food, drinks, granulated tea, gel health foods and confectionery, through the process of condensation, granulation, fluidized bed drying, and powdering using fermented extracts or fermented powders which have undergone fermentation by adding microorganisms to the raw sulfur sulfur raw material Another object of the present invention is to provide a method for preparing healthy food containing sulfur sulfur Cheongshimwon raw material using microorganisms, and a health food prepared by the method.

In the present invention for achieving the above object in the manufacturing method of health food containing sulfur sulfur Cheongsimwon raw material,

Sterilizing the dried state medicine, which is a raw sulfur sulfur raw material, using a rapid sterilizer (G1);

Fermentation process (G2) through the fermentation process by putting microorganisms in the sterilized dry state medicine;

A step (G3) of sterilizing the microorganisms used in the fermentation process by using a rapid sterilization apparatus of the fermented dry state medicine;

Extracting the sterilized dry matter medicinal herb with a vacuum low temperature extractor (G4);

Method for producing a sulfur-containing cheongsimwon raw material containing health food using a microorganism comprising a as a means for solving the problem.

In addition, the present invention is a method for producing a health food containing cow sulfur Cheongsimwon raw material,

Sterilizing the powdered medicinal herb, which is a sulfur-free cheongsimwon raw material, using a rapid sterilizer (G1);

Fermentation process (G2) through the fermentation process by putting microorganisms in the sterilized powdered medicine;

Sterilizing the microorganisms used in the fermentation process using the sterilized powdered medicinal herb (G3);

Drying the sterilized powdered medicine using a drier (G4 ′);

Method for producing a sulfur-containing Cheongshimwon raw material containing health food using microorganisms, characterized in that it comprises another problem solving means.

The method for preparing healthy food containing sulfur sulfur Cheongshimwon raw material using the microorganism of the present invention by the above-mentioned problem solving means and the health food prepared by the manufacturing method are urgent patients by adding fermentation process using microorganisms to the sulfur sulfur raw material herbal medicine In addition, the active ingredient of the sulfur sulfur cheongsimwon effective in strokes and strokes is quickly absorbed and delivered to the human body has the advantage of very excellent absorption rate.

Raw materials, such as food, drinks, granulated tea, gel health foods and confectionery, through the process of condensation, granulation, fluidized bed drying, and powdering using fermented extracts or fermented powders which have undergone fermentation by adding microorganisms to the raw sulfur sulfur raw material Can also be used as

In order to achieve the above effects, the present invention relates to a method for preparing healthy foods containing sulfur-containing cheongsimwon raw materials using microorganisms and health foods produced by the method, which will be described below in detail with reference to preferred embodiments of the present invention. . It should be noted that in the following description, only parts necessary for understanding the present invention will be described, and descriptions of other parts will be omitted so as not to distract from the gist of the present invention.

1 is an embodiment according to the present invention relates to a process block diagram for manufacturing a health food containing sulfur sulfur Cheongshimwon raw materials through the fermentation and sterilization process using the medicine.

Referring to Figure 1 attached to the accompanying drawings of the method for manufacturing a healthy food containing sulfur sulfur cheongsimwon raw material using a microorganism according to the present invention as follows.

The present invention is a method for producing a health food containing cow sulfur Cheongsimwon raw material,

Sterilizing the dried state medicine or the powder state medicine, which is a raw material of sulfur sulfur, by using a rapid sterilizer (G1);

A fermentation process (G2) through which the microorganisms are put into the sterilized dry state medicine or powder state medicine to undergo a fermentation process;

A step (G3) of sterilizing the microorganisms used in the fermentation process by using a rapid sterilization apparatus for the fermented dry state medicine or powder state medicine;

(G4) or extracting the fermented extract with the sterilized dry state medicine in a vacuum low temperature extractor, or

Drying the sterilized powdered medicine using a drier (G4 ′);

It relates to a manufacturing method of sulfur-containing Chungsimwon raw material containing health food using a microorganism comprising a.

The medicinal herbs used in the G1 process are cleaned and dried in a pretreatment process, dried, and cut into slices or cut into 10 ~ 15 cm to prepare dry state medicinal herbs or by using the pulverized dry state medicinal herbs using a grinder. It may be further subjected to a pretreatment process to prepare the powdered medicine through the grinding process.

And the powdered medicinal herbs pulverized in the pretreatment process is preferably the size of the particles 70 ~ 120 mesh (mesh) so that the fermentation according to the inoculation of the microorganism is sufficiently made.

In the pretreatment step, the grinding step is not particularly limited, and a ball mill, a super mill, an automizer mill, a micro-jet mill, a pin, which is commonly used, may be used. It may be crushed using a pin crusher, a colloid mill, or the like.

In the G1 process, it is preferable to sterilize for 10 to 30 minutes at a temperature of 110 ~ 140 ℃ as a process for sterilizing microorganisms inhabiting the dry medicine or powdered medicine. If the sterilization temperature is less than 110 ℃, or sterilization time is less than 10 minutes, not enough sterilization is made, if the sterilization temperature is more than 140 ℃, or more than 30 minutes sterilization time, the effect of the sterilization temperature and time exceeded There is almost no workability.

In the G2 process, the microorganism is preferably inoculated with 1 to 5 parts by weight based on 100 parts by weight of the dry state medicine or the powdered medicine. In addition, the microorganism is preferably 10 ⁸ ~ 10 ⁹ cfu / g in order to sufficiently ferment the dry state medicine or powdered medicine, the fermentation conditions maintain a humidity of 70 ~ 90% at a temperature of 27 ~ 32 ℃ It is desirable to go through the fermentation process for 7-10 days.

As the microorganism to be introduced in the G2 process, one or more selected from Aspergillus oryzea , Ganoderma lucidum fungus, or Shiitake mushroom ( Lentinula edodes ) fungus are used. It is possible.

It is a process for sterilizing microorganisms used in the fermentation process in the G3 process. Sterilization conditions are preferably sterilized for 10-30 minutes at a temperature of 110 ~ 140 ℃. If the sterilization temperature is less than 110 ℃, or sterilization time is less than 10 minutes, not enough sterilization is made, if the sterilization temperature is more than 140 ℃, or more than 30 minutes sterilization time, the effect of the sterilization temperature and time exceeded There is almost no workability.

In the G4 process, the extraction solvent is preferably used to extract at a low temperature of 40 to 60 ° C. under a vacuum of 10 to 100 mmHg. At this time, the extraction solvent used may be selectively used according to the use from ethanol, glycerin, butylene glycol, distilled water and the like.

In the vacuum low temperature extraction, when the dry state medicine is introduced into the vacuum tank, the inside of the vacuum tank is evacuated, and the extraction solvent is supplied into the vacuumized vacuum tank, and the extraction solvent is dried by the low pressure inside the vacuum tank. As it penetrates into state medicine, it is absorbed. Then, by heating the vacuum tank, the dry state medicine and the solvent are naturally stirred, and the active ingredient of the dry state medicine is extracted to the outside by the pressurization device during the extraction process. The extraction solvent supplied in the vacuum state is in the dry state medicine Since it is completely absorbed while penetrating inside, it can be extracted quickly by the effect of improving heat conduction, and it can be removed at the low temperature of 40 ~ 60 ℃ under vacuum of 10 ~ 100 mmHg. By preventing the fermentation extract containing a high purity of the active ingredient can be extracted.

And according to the extraction solvent used in the G4 process may further include a step of removing the extraction solvent by heating the fermented extract extracted in the process, wherein the heating temperature is at a temperature of 70 ~ 290 ℃ depending on the type of extraction solvent It is preferable to heat.

In the G4 'process, the water content of the sterilized powdered medicine is dried to be 5 to 10%. Excessive energy is consumed when drying to lower the moisture content of the sterilized powdered medicines to less than 5%. Powders sterilized due to excess moisture content when dried to exceed 10% of the water content of the sterilized powdered medicines There is a fear that the state medicine is altered.

And in the present invention by using the additives (honey, glutinous rice, starch, etc.) to the fermented powder after the drying process of the G4 'process can be made to the size of the ring (2g) prescribed in the synonym dictionary, health food in various forms It can be used as a raw material.

The sulfur sulfur cheongsimwon raw medicinal herbs used in the present invention generally contains 25 kinds of prescription constituents, and the range of active ingredient of herbal medicine is resin glycoside, phthalide, quinone, anthraquinone, C3-C6 organic acid, aldehyde, carbon hydrate. It is known to exist in a large number of active ingredients such as lignan, monoterpene, saponin, steroid, flavonoid tannin, cinnamic ingredient, resin and resin complex, cyanide glycoside and amino acid component.

And the sulfur sulfur cheongsimwon raw materials used in the present invention is different depending on the prescription according to the consent and Sasang medical care.

First, the sulfur sulfur cheongsimwon raw materials used in accordance with the agreement in the present invention is about 25-30 parts by weight, licorice 18-22 parts by weight, 8-12 parts by weight of ginseng, 8-12 parts by weight, new song 8-12 parts by weight, Seoleok 6 ~ 10 parts by weight, 5 ~ 9 parts by weight of soybean yellow rice, 5 ~ 9 parts by weight of broiler, 5 ~ 9 parts by weight of glue, 5 ~ 7 parts by weight of Baekjak, 5-7 parts by weight of Macmundong, 5-7 parts by weight of gold, Angelica 5-7 weight part, windproof 5-7 weight part, injection 5-7 weight part, Baek 5-7 weight part, Shiho 4-6 weight part, Gil length 4-6 weight part, Altitude 4-6 weight part, Baekbokyeong 4 to 6 parts by weight, 4 to 6 parts by weight of uterus, 4 to 6 parts by weight of sulfur, 3 to 5 parts by weight of nutrients, 3 to 5 parts by weight of musk, 3 to 5 parts by weight of cephalophyte, 2 to 4 parts by weight of Seokwoong sulfur, white worm 2 It consists of -4 weight part, Po health 2-4 weight part, 0.1-1.3 weight part of gold leaf, and 40-90 weight part of control.

In addition, the sulfur sulfur cheongsimwon raw materials used according to the filamentous treatment in the present invention is 25 to 30 parts by weight of acid powder, 8 to 12 parts by weight of turmeric, 6 to 10 parts by weight of soybean paste, 5 to 9 parts by weight of soybean sulphate, 5 to 7 parts by weight of Mcmundong Wealth, 5-7 parts by weight, 4-6 parts by weight, 4-6 parts by weight, 4-6 parts by weight, 4-6 parts by weight of sulfur, 3-5 parts by weight of nutritious, 3-5 parts by weight, cedar 3-5 parts by weight It contains 2-4 weight part of baekryeom, 0.05-0.08 weight part of gold leaf, and 1-3 weight part of maeyun meat as a main component.

And the mountain drug (山 은) is used in oil well, nocturnal enuresis, low back pain, frequent urination, cold sweat, forgetfulness, sogal, licorice (甘草) is used for constipation, eczema, carbuncle, spear, gastric ulcer, hepatitis, bronchitis.

Ginseng (人蔘) is one of the best herbal medicine among the herbal medicine, the herbal medicine 'new farming menarche' is said to nourish the five chapters, that is, liver, heart, lungs, kidneys and spleen to nourish and stabilize the spirit. Huang (蒲黃) is used to urinate, lobster, bleeding, bleeding, blood cell, and singok (神曲) is used for food, it is used for hungry stomach.

The epidemic (犀角) is used for plight, blood fever, nosebleed, swelling, and soothing. The soybean yellow velvet (大豆 黃 卷) is used for sequencing, fever, nausea, and stool. It is used to treat diseases caused in the early stages, and glue is used to accelerate the enhancement of red blood cells and hemoglobin in the blood, increase calcium absorption and accumulation in the body, increase blood calcium slightly, and promote progressive muscle dystrophy. Prevents and treats.

Baekjak (白 芍藥) is used to relieve blood pressure and blood vessels well, Macmundong (麥 門冬) is effective in strengthening the lungs, vitality, improve winter stamina, prevent cough and asthma There is, golden (黄 芩) contains baicalin (baicalin), baicalein (baicalein) ingredients, anti-inflammatory, anti-allergic action, allergic asthma is relieved. Since the golden extract has an effect of significantly blocking ischemic nervous system diseases, it is used as a prophylactic and therapeutic agent for neurological diseases such as stroke, Parkinson's and brain diseases including senile dementia. Dongguk and Cheongung function to facilitate blood circulation. Windproof is used to prevent wind and to remove cough and sputum.柴胡, baekbokyeong (白 茯 笭), Seokwoong-hwang (石 雄黃) and gold leaf (은) is a medicine that is used as an emergency in the nervous system diseases, has a calming effect.

Gilgyeong (행 仁) and passersby (杏仁) to solve the bleeding of the lungs, brain, whaling (牛黃) is used for jingyeong, cardiac, coercive, fever, diarrhea, nourishment angle (羚 羊角) head pain and dizziness Deo, heart, jeon, breeze, eyes are red and painful, musk is shock, collapse, rheumatoid arthritis, clear the mind and circulate blood, dragon brain conjunctivitis, conjunctivitis, pharyngitis, deafness It is said to be effective in the back.

Pneumonia has antipyretic effect, po health has a diuretic effect that promotes the function of the liver and facilitates the metabolism of water. The control (大棗) makes the stomach feel comfortable, and the five plum meats (렴 梅肉) converge. It is good at helping digestive organs, such as stomachache, suits, and insect repellent.

Microorganisms prepared through the above-mentioned process are added to fermented extracts or fermented powders which have undergone a complete fermentation process. It can also be used as raw materials for granule tea, gel health food and confectionery.

The present invention is processed by the fermentation process using the microorganisms of sulfur sulfur cheongsimwon raw materials, after the fermentation so that the molecular unit of the drug or nutrients are fine so that the absorption of the herbal medicine to the human body is fine, then converted into the fermentation product Even if you drink it regardless of male, female, old or small constitution, it is a stroke, forgets well, is surprised, it is not clear, it is often surprised, the chest is stuffy, the face is red, insomnia, epilepsy It is effective in strokes, cerebral hemorrhages, restraints of strokes, thrombosis, hysteria, etc., and especially in synonymic dictionaries, it is effective to lose spirit and not speak and to use hands and feet.

Hereinafter, the manufacturing method of the sulfur-containing Chungsimwon raw material containing health food using the microorganism according to the present invention and the health food prepared by the manufacturing method will be described in more detail with reference to the following examples.

1. Preparation of health food containing raw sulfur Cheongsimwon

(Example 1)

Raw materials of sulfur sulfur cheongsimwon 28 parts by weight of acid, 20 parts by weight of licorice, 10 parts by weight of ginseng, 10 parts by weight of turmeric, 10 parts by weight of new song, 8 parts by weight, 7 parts by weight of soybean yellow soybean, 7 parts by weight of broiler, 7 parts by weight of glue , 6 parts by weight of Baekjak, 6 parts by weight of Macmundong, 6 parts by weight of gold, 6 parts by weight of Angelica, 6 parts by weight of windproof, 6 parts by weight of injection, 6 parts by weight of leachate, 5 parts by weight of seahawk, 5 parts by weight of algae, 5 parts by weight of almond , 5 parts by weight of Baekbokyeong, 5 parts by weight of uterus, 4.8 parts by weight of sulfur, 4 parts by weight of nutrients, 4 parts by weight of musk, 4 parts by weight of cerebrum, 3.2 parts by weight of Seokwoong sulfur, 3 parts by weight of baekryeom, 3 parts by weight of po health, 0.12 weight of gold leaf In addition, the dried state medicines containing 40 parts by weight of the main component was washed clean, dried, cut into 10 ~ 15 cm fragments and sterilized for 30 minutes at a temperature of 110 ℃ using an autoclave, a rapid sterilizer.

In addition, 3 parts by weight of microorganisms in which Aspergillus oryzea and the fungus Ganoderma lucidum fungus and Lentinula edodes fungus are uniformly inoculated to inoculate 3 parts by weight so that dry matter medicine can be sufficiently fermented. 10 ⁹ cfu / g was used, and the fermentation conditions were maintained at a humidity of 90% at a temperature of 27 ℃ for 7 days after the fermentation process sterilized for 30 minutes at a temperature of 110 ℃ using a rapid sterilizer autoclavor I was. Sterilized dry state medicinal herbs were extracted at low temperature in a vacuum low temperature extractor using distilled water as a distilled water at a temperature of 40 ° C. under vacuum of 100 mmHg to extract the fermented extract of cow sulfur Cheongsimwon raw material.

(Example 2)

Raw materials of sulfur sulfur cheongsimwon 28 parts by weight of acid, 20 parts by weight of licorice, 10 parts by weight of ginseng, 10 parts by weight of turmeric, 10 parts by weight of new song, 8 parts by weight, 7 parts by weight of soybean yellow soybean, 7 parts by weight of broiler, 7 parts by weight of glue , 6 parts by weight of Baekjak, 6 parts by weight of Macmundong, 6 parts by weight of gold, 6 parts by weight of Angelica, 6 parts by weight of windproof, 6 parts by weight of injection, 6 parts by weight of leachate, 5 parts by weight of seahawk, 5 parts by weight of algae, 5 parts by weight of almond , 5 parts by weight of Baekbokyeong, 5 parts by weight of uterus, 4.8 parts by weight of sulfur, 4 parts by weight of nutrients, 4 parts by weight of musk, 4 parts by weight of cerebrum, 3.2 parts by weight of Seokwoong sulfur, 3 parts by weight of baekryeom, 3 parts by weight of po health, 0.12 weight of gold leaf Wealth, dry 90% by weight of the dried state-based medicinal herbs as a main component to clean, dried, cut into 10 ~ 15 ㎝ cut into pieces of 70 mesh (mill) using a grinder and then rapid sterilizer Sterilization was carried out for 30 minutes at a temperature of 110 ℃ using a torque lever.

Also, inoculate 3 parts by weight of microorganisms in which Aspergillus oryzea and fungus Ganoderma lucidum fungi and Lentinula edodes fungi are uniformly mixed so that the powdered medicinal herbs can be fermented sufficiently. 10 ⁹ cfu / g was used, and the fermentation conditions were maintained at a humidity of 90% at a temperature of 27 ℃ for 7 days after the fermentation process sterilized for 30 minutes at a temperature of 110 ℃ using a rapid sterilizer autoclavor I was. The sulfur content of Cheongsimwon powder was prepared by drying the sterilized powdery building material to have a water content of 10%.

2. Evaluation of Absorption Rate of Active Ingredients of Sulfur Cheongsimwon

Example 1 and Comparative Example 1 was prepared by using the sulfur-free Cheongshimwon raw materials prepared as in Example 1 and Example 2 and orally administered to rats (rat) of the experimental animal using commercially available sulfur-free Cheongshimwon Absorption rate was compared by measuring the blood concentration of Baicalin, an indicator of the agent, over time.

The experimental animals were orally administered 1 ml, 115 ml, and 138 ml of the samples of Examples 1, 2, and Comparative Example 1 using rats (250 ± 30 g), respectively, to determine the amount of baikal first administered. In the same manner, the animals were anesthetized before administration of the sample, and then arterial intubation was performed on the femoral artery, and blood bleeding (every 0.3 ml) was performed therefrom. After administering each sample, blood was collected every certain time (2 minutes, 5 minutes, 10 minutes), and immediately centrifuged (3.000 rpm, 10 minutes) to separate plasma µg of the upper layer, which was then used for HPLC. Kampherol-3-rutinoside (0.34 mg), an internal standard, was added and quantified by balicalin by HPLC. The same experiment was repeated eight times, and the results of measuring the average value of blood concentration are shown in Table 1 below.

(Unit: ㎍ / ml) division Example 1 Example 2 Comparative Example 1 2 mins 4.66 3.94 0.89 5 minutes 3.18 2.87 2.01 10 minutes 0.16 1.19 5.02

As can be seen from Examples 1 and 2 through the fermentation process to prepare the fermentation extract and the fermentation powder, compared to the comparative example, the absorption starts within a short time (2 minutes), the index component of the baccalin (baicalin) It was shown that blood concentration increased in a short time. In particular, in Example 1, by adding the fermentation extract in the liquid state, it can be seen that the water absorption is superior to Example 2 in the powder state. Therefore, it can be confirmed that the absorption rate of the body is very excellent as the blood concentration of Baikalin shows a high blood concentration in comparison with the comparative example within a short time.

However, Comparative Example 1 was administered in the circulating sulfur sulfur cheongsimwon commonly distributed in the short time, the absorption is slow, but the absorption rate was found to increase with time.

Therefore, the present invention adds the fermentation process using microorganisms to the sulfur medicinal raw materials of sulfur sulfur, so that the active ingredient of sulfur cheongsimwon is quickly absorbed and delivered to the human body, and the absorption rate is very good, and the fermentation extract or fermentation powder that has undergone the fermentation process by adding microorganisms. Silver can be used as a raw material for foods, drinks, granulated tea, gel health foods, and confectionery through processes such as concentration, granulation, fluid bed drying, and powdering.

As described above, the manufacturing method of the sulfur-containing Cheongshimwon raw material-containing health food using the microorganism according to the present invention and the health food prepared by the manufacturing method are described through the above-described preferred embodiments, and the superiority was confirmed, but the corresponding technology Those skilled in the art will appreciate that various modifications and changes can be made in the present invention without departing from the spirit and scope of the invention as set forth in the claims below.

1 is an embodiment according to the present invention relates to a process block diagram for manufacturing a health food containing sulfur sulfur Cheongshimwon raw materials through the fermentation and sterilization process using the medicine.

Claims (9)

In the manufacturing method of the health food containing the sulfur sulfur cheongsimwon raw material, Sterilizing the dried state medicine, which is a sulfur-based cheongsimwon raw material, at a temperature of 110 to 140 ° C. for 10 to 30 minutes using a rapid sterilizer (G1); Fermentation process (G2) through the fermentation process by inoculating 1 to 5 parts by weight of microorganisms based on 100 parts by weight of the sterilized dry state medicines; Sterilizing the microorganisms used in the fermentation process at a temperature of 110 to 140 ° C. for 10 to 30 minutes using a rapid sterilization method of the fermented dry state medicine (G3); Extracting the sterilized dry state medicinal herb at a low temperature of 40 to 60 ° C. under a vacuum of 10 to 100 mmHg using an extraction solvent with a vacuum low temperature extractor (G4); ≪ / RTI > The microorganism may be used by selecting one or more from Aspergillus oryzea , fungus Ganoderma lucidum fungus or Lentinula edodes fungus, The microorganism is 10 ⁸ ~ 10 ⁹ cfu / g so that the dry state medicine can be sufficiently fermented Method of producing health food containing sulfur sulfur Cheongshimwon raw materials using microorganisms, characterized in that the fermentation process for 7 to 10 days by maintaining a humidity of 70 ~ 90% at a temperature of 27 ~ 32 ℃ using. In the manufacturing method of the health food containing the sulfur sulfur cheongsimwon raw material, Sterilizing the powdered medicinal herb, which is a sulfur-based cheongsimwon raw material, at a temperature of 110 to 140 ° C. for 10 to 30 minutes using a rapid sterilizer (G1); A fermentation step (G2) through which the microorganism is inoculated with 1 to 5 parts by weight based on 100 parts by weight of the sterilized powdered medicinal herb; A step (G3) of sterilizing the fermented powdered medicinal herb using a rapid sterilization apparatus for 10 to 30 minutes at a temperature of 110 to 140 ° C .; The sterilized powdered medicine is a step of drying using a dryer so that the water content is 5 to 10% (G4 ′); ≪ / RTI > The microorganism may be used by selecting one or more from Aspergillus oryzea , fungus Ganoderma lucidum fungus or Lentinula edodes fungus, The microorganism is characterized in that the fermentation process for 7 to 10 days by maintaining the humidity of 70 ~ 90% at a temperature of 27 ~ 32 ℃ using 10 ⁸ ~ 10 ⁹ cfu / g so that the powdered medicine is sufficiently fermented Method for producing health food containing sulfur sulfur cheongsimwon raw material using microorganisms. delete delete delete delete delete delete Healthy food containing sulfur sulfur Cheongshimwon raw material using microorganisms, which is produced by the method according to any one of claims 1 and 2.

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