CN102579658A - Traditional Chinese medicinal composition for curing hyperuricacidemia, gout and urinary retention - Google Patents
Traditional Chinese medicinal composition for curing hyperuricacidemia, gout and urinary retention Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal composition for curing hyperuricacidemia, gout and urinary retention. The traditional Chinese medicinal composition comprises fruit of austral akebia, Digua fig stem, China fir and weeping willow, and specific ingredients and dosage of a prescription are modified according to symptoms of patients. The composition is capable of fully utilizing traditional Chinese medicinal resources, reducing cost, improving curative effects, clearing heat, promoting diuresis, promoting blood circulation to arrest pain, promoting urination, obviously reducing blood uric acid levels of patients to the range of normal values, and markedly eliminating gout symptoms in different parts of patient bodies. Besides, the traditional Chinese medicinal composition can be taken for a long term without any toxic and side effects and has a certain preventive effect on the hyperuricacidemia and the gout.
Description
Technical field
The present invention relates to a kind of hyperuricemia disease that is used to treat, can reduce patient's serum uric acid level significantly, and the gout symptom of patient's different parts is also had elimination effect significantly, this medicine is taken the Chinese medicine composition that human body is had no toxic and side effects for a long time.
Background technology
The increase of Along with people's growth in the living standard and operating pressure, blood uric acid is too high to have become an important paathogenic factor gradually.At first, the food of intravital old cell of people and absorption especially is rich in the food (like pluck, seafood etc.) of purine, and in the metabolic processes, contained nucleic acid oxidation Decomposition product is a purine in vivo.The purine that produces in the body can reoxidation be 2,6 in liver, 8-trioxypurine, i.e. uric acid.Wherein, 2/3rds uric acid can excrete with urine through kidney, in addition three/for a moment through the discharge of feces and perspiration.Under the normal condition, uric acid approximately maintains 1200 milligrams in the body, and every day, newborn written treaty was 600 milligrams, drained 600 milligrams simultaneously, was in poised state basically.If but the interior uric acid generation of body too much has little time to drain or the degeneration of urate excretion mechanism; Retention is too much in vivo then to cause uric acid; When the blood uric acid concentration will influence the normal function of human body cell during greater than 7 mg/litre, ignore for a long time and will cause multiple disease.During the blood uric acid excessive concentration, uric acid is deposited in joint, cartilage and the kidney with the form of sodium salt, causes and organizes foreign body inflammatory reaction, i.e. gout.
At present, China hyperuricemia patient has reached 1.2 hundred million people, and annual speed with 9.7% increases, and wherein the patient of 5%-12% can develop into gout.During the blood uric acid excessive concentration, uric acid is deposited on positions such as joint, cartilage, kidney with the form of sodium salt, causes and organizes the foreign body inflammatory reaction, be i.e. gout.Its clinical characters is: hyperuricemia, acute arthritis are shown effect repeatedly, tophus formation, chronic arthritis and joint deformity, and kidney urate calculus and gouty excess of the kidney matter pathological changes occur in the course of disease later stage.Gout has become the second largest metabolic disease that China is only second to diabetes, the health of engulfing people wantonly.Hyperuricemia disease is except that directly causing the gout; Also often cause following disease: gouty nephropathy, uremia's nephritis, acute obstruction property nephropathy, atherosclerosis, hypertension, cardiovascular and cerebrovascular disease, tophus, urinary system calculus, acute arthritis, nephropathy, erythrocytosis, hepatic lesions, thyroid function attenuating, multiple myeloma, gestation reaction erythrocytosis, or the like.These diseases have greatly influenced daily life and operate as normal, have formed a social problem of being badly in need of solution.
Clinically, the too high patient of uric acid is normal adopts following several method to handle.At first, reduce the endogenous uric acid:, also suppress purine simultaneously and be oxidized to uric acid through taking in effective anti-oxidants (such as ASTA astaxanthin and so on) inhibition nucleic acid oxidation Decomposition; Allopurinol and metabolite oxypurinol thereof all can suppress xanthine oxidase, and stoping hypoxanthine and xanthine metabolism is uric acid, thereby has reduced the generation of uric acid, can reduce by 80% uric acid source through above two approach; Secondly, reduce exogenous uric acid: reduce the absorption of high purine food, can reduce by 20% uric acid; Once more, take certain methods to promote the discharge of uric acid: like appropriate alkalized urine (sodium bicarbonate or zheganmian and so on), the medicine that promotes the uric acid discharge is like third semi-annular jade pendant easypro (probenecid) and benzbromarone (Benzbromarone); At last, to acute gout, the patient can take anti-inflammation drugs diclofenac sodium (Diclofenac Sodium) and Celebrex (celecoxib).Use uricosureic agent, urine uric acid increases, and urine pH is reduced, thereby is prone to produce renal calculus, or uric acid crystal is calm in the renal tubules.Because blood uric acid reduces, and the uric acid in uric acid storehouse is mobilized, blood uric acid can impel gouty attack,acute through articular cavity again.For preventing above-mentioned accident, adopt alkalescent medicine (sodium bicarbonate or sodium citrate) alkalized urine, increase water uptake, take colchicine or indomethacin simultaneously, prevent acute attack, treat that blood uric acid is normal after, can drug withdrawal.Just totally come, these drug side effectes are bigger, do not reach the purpose of treating both the principal and secondary aspects of a disease.
" gout " name of disease is also arranged in the Chinese medicine, and ancient Chinese medicine doctor is discussed to some extent.Zhu Danxi special piece of writing of row gout once just in " Further Discourses on the Properties of Things ", cloud: " gout person, big rate is heated from boiling because of blood, thereafter or paddle or upright wetland ... cold and cool outer fighting, warm blood must be trembled with fear, antiperspirant is turbid to stagnate, so have a pain, night then pain very, row is in sun also.”。Gout in the doctor trained in Western medicine is equivalent to diseases such as " arthralgia aggravated by cold ", " severe and migratory arthralgia ", " beriberi " in the traditional Chinese medical science, and therefore, the traditional Chinese medical science thinks that then gout belongs to the arthromyodynia category, and hyperuricemia belongs to turbid poison.Ancient Chinese medicine doctor thinks that natural endowment is not enough, or takes good care of oneself accidentally, and addiction does not have joint; The surfeit greasy and surfeit flavour causes spleen and stomach function disorderly, and water paddy is reforming not; Turbid poison is given birth to thereupon, is detained in the blood, and malicious heresy is stayed for a long time; If steam to make qi-blood-body fluid, generate the expectorant stasis of blood, tie in the joint, skin, kidney etc. can become sucutaneous nodule, enclosed mass.The poison heresy is stayed in kidney, the vital essence of damage kidney, and cards such as the difficulty in urination, obstruction and rejection can appear in the renal function decline.If malicious heresy receives exopathogen priming poison resistance meridians, then joint congestion and swelling pain burst.So the intermission advocates to reuse the article of transferring the spleen reinforcing kidney, the source of life in the exhausted poison.According to bibliographical information, Chinese herbal medicine such as Radix Puerariae, Herba Lysimachiae, Herba Lophatheri, Herb Gynostemmae Pentaphylli, Phellinus igniarius (L. ex Fr.) Quel., Fructus Ligustri Lucidi, Cordyceps all have the effect of certain treatment hyperuricemia disease.Therefore, motherland's medical science is being brought into play indelible effect aspect the treatment hyperuricemia disease long history being arranged.
Treatment by Chinese herbs gout, hyperuricemia receive much attention, and have to discuss stage by stage to control, and special side's treatment is also arranged, and all obtain better curative effect.(Zhu Xuan tawny daylily etc. such as Zhu Xuan tawny daylily; Pyretic arthralgia disappears and treats the experimentation ［ J ］ of acute gouty arthritis, Chinese drug standard, 2002; 3:57) adopt the compound recipe of compositions such as Rhizoma Dioscoreae Septemlobae, Rhizoma Polygoni Cuspidati, Radix Notoginseng, Cortex Phellodendri can obviously alleviate rat paw edema degree due to the carrageenin; Induce rat paw edema behind 4 h, can obviously alleviate the swelling degree to uric acid sodium, the length of holding time, and can reduce prostate E2 content in the inflammatory foot sole of the foot.(Li Juan etc. such as Li Juan; The experimentation ［ J ］ of TONGFENGNING oral liquid treatment acute gouty arthritis, West China pharmaceutical journal, 1998; 13:159) adopt the compound recipe of compositions such as Herba Epimedii, Radix Platycodonis, Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens can suppress the rat paw edema that uric acid sodium causes; Significantly uric acid reducing sodium is induced the leukocyte count in the rabbit acute gouty arthritis joint fluid, can significantly suppress rat paw edema and xylene induced mice ear swelling that carrageenin causes, can obviously suppress the granulomatous formation of rat; Mice there is inhibitory action because of the caused pain reaction of chemical stimulation and thermostimulation, points out this compound recipe that tangible antiinflammatory, analgesic activity are arranged.Wang Xiuhua etc. (Wang Xiuhua etc., the clearing heat and expelling damp method is to the influence ［ J ］ of rabbit knee acute gouty arthritis cell because of IL1 β and NO, and the traditional Chinese medical science bonesets; 2001; 13:171) induce the gout Rabbit Model with the processing of clearing heat and expelling damp Chinese medicine by uric acid sodium, and contrast with colchicine, the result shows; Its curative effect is superior to the colchicine group, and the effect of better prevention gout is arranged.Chen Wenzhao etc. (Chen Wenzhao etc., tetrandra and astragalus Job's tears soup are to the influence ［ J ］ of acute gout peripheral neurotransmitter, the Chinese Medicine journal, and 1997,4:25) utilize medicine diuretic such as Radix Stephaniae Tetrandrae, the Radix Astragali to cooperate the Radix Angelicae Sinensis treatment acute gouty arthritis of invigorating blood circulation.Its analgesic effect is microcirculation improvement, alleviates the excitation attitude of teleneuron, improves the threshold of pain, thereby eases the pain.Gouty arthritis is contained with pathogenic heat, double rheumatism two heresies that accompany.Wind having the nature of frequent change is then fallen ill rapidly and violent, and dampneee being viscous and lingering is then loved touching and difficult healing for a long time.Treatment is main with clearing away heat and expelling wind, dehumidifying blood stasis dispelling.Can use Baihu Jia Guizhi Tang, Semen Coicis soup, three wonderful soup etc. (what immortality etc., the experience ［ J ］ of treatment gouty arthritis, Chinese Chinese medicine information magazine, 2004,3:266).The compound of Chinese medicine gout obtains bigger progress, and some research has been deep into cell and molecular biology level.
In the prior art scheme:
The Chinese medicine worker of China has developed the Chinese patent medicine product of a plurality of treatment gouts or hyperuricemia disease.Zhu Danxi has set forth the medicaments compound and the application process thereof of a plurality of treatment gouts in its works " danxi's experiential therapy ", the prescription that therefrom is developed as medicine has: two wonderful balls, three wonderful balls, SIMIAO WAN.In addition; The various nationalities people have according to clinical other medicine with better therapeutic effect with the experience exploitation: gout stator, TONGFENGDING capsule, gout relaxing tablet, gout relieving capsule, Bin leaves of pulse plants gout mixture, 25-component donkey blood ball, 25-component catechu ball, compound recipe are stretched muscle capsule, damp and hot numbness capsule, Bazhen Pills, LIUWEI DIHUANG WAN, JINGUI SHENQI WAN, sinew-Soothing Blood-Quickening Tablet, or the like.Wherein, 25-component donkey blood ball and compound recipe are stretched rules of origin such as muscle capsule in Yi nationality's medicine, Miao Ethnomedicine and the Tibetan medicine of China.Therefore, the Chinese patent medicine product of new treatment gout, hyperuricemia disease and the urine retention of exploitation is feasible from the valuable Chinese medicine resource of China.
Summary of the invention:
The purpose of this invention is to provide a kind of natural resources of Chinese medicinal materials that makes full use of, easy to process, with low cost, hyperuricemia disease, gout and urine retention there are the Chinese medicine composition of treatment hyperuricemia disease, gout and the urine retention of remarkable result.
The present invention is achieved in that
The present invention treats the Chinese medicine composition of hyperuricemia disease, gout and urine retention, it is characterized in that it is to be processed by the raw material that comprises following weight portion:
Fructus Akebiae 20-60
Caulis et Folium fici Tikouae 20-60
Lignum seu Ramulus Cunninghamiae Lanceolatae 10-50
Salix babylonica L. 15-50.
It is processed by the raw material of following weight portion:
Mahonia fortunei (Lindl.) Fedde 15-50.
It is processed by the raw material of following weight portion:
Fructus Akebiae 30
Caulis et Folium fici Tikouae 30
Lignum seu Ramulus Cunninghamiae Lanceolatae 20
Salix babylonica L. 20.
It is processed by the raw material of following weight portion:
Fructus Akebiae 25
Caulis et Folium fici Tikouae 30
Lignum seu Ramulus Cunninghamiae Lanceolatae 15
Salix babylonica L. 10
Mahonia fortunei (Lindl.) Fedde 20.
Raw material is added 5～16 times of water gagings, and heating decocts, and collects volatile oil, keeps little and boils 30～120 minutes, filters; Collect fried liquid, medicinal residues add 4～12 times of water gagings again, and heating decocts to boiling, and keeps little and boils 30～120 minutes; Collect volatile oil, filter, collect fried liquid, merge fried liquid; Volatile oil merges to be placed; Fried liquid is concentrated after drying, obtain extract solid, volatile oil and extract are processed Chinese patent medicine as raw material.
Raw material is added 12 times of water gagings, and heating decocts, and derives steam, collects upper strata volatile oil after the condensation, keeps little and boils 90 minutes; Filter, collect fried liquid, medicinal residues add 10 times of water gagings again, and heating decocts to boiling, and keeps little and boils 60 minutes; Collect volatile oil, filter, collect fried liquid, merge fried liquid; Volatile oil merges the back and adds anhydrous sodium sulfate drying, places in 4 ℃ of following low temperature; It is 1.16 that fried liquid is evaporated to relative density in 60 ℃; Import spray drying device; In feed liquor speed is that 30 ml/min, EAT are to carry out drying under 120 ℃ the condition, collects pale yellow pressed powder, and volatile oil and pale yellow pressed powder are processed Chinese patent medicine as raw material.
Chinese medicine composition is medicinal tea or water decoction or granule or tablet or pill or capsule or drop pill or oral liquid or tincture or dry syrup or syrup or Emulsion or powder or spray or lotion or suppository.
Fructus Akebiae
Holboellia latifoliaWall., it is fried to have another name called Fructus Akebiae, August, is the fruit (" Chinese pharmacopoeia 2010 version one one) of Lardizabalaceae plant Caulis Akebiae, threeleaf akebia or Caulis Akebiae.This medical instrument has clearing away heat-damp and promoting diuresis; Liver-smoothing, qi-regulating; Blood circulation and channel invigorating; Promoting the circulation of QI to relieve pain; The parasiticidal effect of diuresis is used for gastral cavity side of body distending pain, the amenorrhea dysmenorrhea, and dysuria, snake bite and insect sting (" one one of Chinese pharmacopoeia version in 2010, " Sichuan Chinese medicinal herbal ").Medical material contains akebin (akebin) A, B, C, D, E, F, G, oleanolic acid-3-rhamanopyranosyl galactoside, helexin-3-xylosyl galactoside; Helexin-3-rhamanopyranosyl galactoside, oleanolic acid-3-glucosyl group galactoside, helexin-3-Ah Bai sugar-28-rhamanopyranosyl diglucoside; Oleanolic acid-3-rhamanopyranosyl arabinose-28-rhamanopyranosyl diglucoside, helexin-3-rhamanopyranosyl arabinose-28-rhamanopyranosyl diglucoside, helexin-3-xylosyl rhamanopyranosyl galactoside; Arjunolic acid (arjunolic acid), arjunolic acid falls in 20 (29) dehydrogenations-30-, falls arjunolic acid-28-rhamanopyranosyl diglucoside; Arjunolic acid-28-xylosyl rhamanopyranosyl diglucoside; Olein, glyceryl linolenate, chemical constituents such as tripalmitin (Wang Jiaming etc.; Fructus Akebiae chemical constitution study [J]; Chinese Pharmaceutical Journal, 2008,43 (2): 155).The Fructus Akebiae pill for curing psychosis that with the Fructus Akebiae is monarch drug has good effect (" formulary of peaceful benevolent dispensary "), and is not also having relevant report aspect prevention and treatment hyperuricemia disease, gout and the urine retention.
Caulis et Folium fici Tikouae is the moraceae plants Radix Pachyrhizi Erosi
Ficus TikouaThe stem and leaf of Bur (" Guizhou side's medicine among the people collection ").Main product in Guangxi, ground such as Guizhou, Hunan, Sichuan, Yunnan, in Guizhou as Miao ethnic group's conventional crude drugs, its nature and flavor bitter cold, nontoxic (" Sichuan Chinese medicinal herbal ").Its function cures mainly and is heat clearing away, and dampness removing invigorates blood circulation, detoxifcation; Control the cough due to pathogenic wind-heat, dysentery, edema; Jaundice, rheumatalgia, bleeding hemorrhoids; Amenorrhea, leukorrhagia, infantile dyspepsia; Traumatic injury, innominate toxic swelling (" classification medical herbs property ", " Tian Bao book on Chinese herbal medicine ", " Guizhou side's medicine among the people collection ", " Sichuan Chinese medicinal herbal ", " Guangxi Chinese herbal medicine ", " Yunnan Chinese herbal medicine ", " Hunan medicine will ").Main chemical compositions has: 4-stigmastene-3-ketone, bergapten, Amyrin, sitosterol, coumaric acid methyl ester, caffeic methyl ester, allantoin, oleanolic acid and daucosterol (Guan Yongxia; Yang your pupil etc.; Miao Ethnomedicine Caulis et Folium fici Tikouae The Chemical Constituents [J]; Chinese herbal medicine, 2007.38 (3): 342-344).Both at home and abroad the pharmaceutical research to this platymiscium shows: this platymiscium has blood sugar lowering, relaxing smooth muscle, antitumor, effect (Zhong X Q such as antibiotic; Xu H H.The studied survey on the offcinal of Moraceae Ficus L [J]. Chin Tradit Herb Drugs, 2000. 31 (9): 3-4).Caulis et Folium fici Tikouae, contain Caulis et Folium fici Tikouae compound recipe and contained chemical constituent thereof and also do not having relevant report aspect prevention and treatment hyperuricemia disease, gout and the urine retention.
Lignum seu Ramulus Cunninghamiae Lanceolatae is a Taxodiaceae araucaria plant Lignum seu Ramulus Cunninghamiae Lanceolatae
Cunninghamia lanceolata(Lamb.) Hook., Chang Yigen, bark, cone, timber, leaf and China fir joint are used as medicine.This plant also is the treatment that reported first is used for hyperuricemia disease and gout.Its nature and flavor are hot, and tepor is nontoxic, has wind-expelling pain-stopping, and dissipating blood stasis hemostatic function (Tang Materia Medica, " book on Chinese herbal medicine converges and says ") is mainly used in chronic tracheitis, stomachache, the treatment of rheumatic arthritis; Traumatic injury is controlled in external, burn and scald, traumatic hemorrhage, allergic dermatitis (" glossary of Herbs and Drugs commonly used among the people ").The Lignum seu Ramulus Cunninghamiae Lanceolatae modern pharmacy is used with research few, belongs to the clinical medical material that seldom uses.
Salix babylonica L. comprises branch and the leaves that takes off from Salicaceae plant Salix babylonica L., and long applicating history is arranged in Chinese medicine and ethnic drug.Wherein, branch is used to dispel the wind, diuresis, pain relieving, detumescence.The dispelling the wind and dampness pathogens arthralgia pain, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum, Folium Salicis Babylonicae have clearly loose, diuresis, antiinflammatory, antidotal effect (handbook of Prescription for Emergency, Compendium of Material Medica, supplementary Amplifications of the Compendium of Materia Medica).Also contain abundant iodine in the willow, it is the big good medicine of treatment endemic goiter.Its xylem contains abundant salicin, and salicin is salicylic prodrug, also is the basis that famous medicine aspirin is found, safer more stable treatment and health-care effect are arranged.Modern Application proves that the Chinese patent medicine of processing with Folium Salicis Babylonicae all has excellent curative to treatment coronary atherosclerotic heart disease, chronic tracheitis, infectious hepatitis, burn and scald, upper respiratory tract infection, tracheitis, pneumonia, cystitis, pyogenic parotitis, mastitis, pharyngolaryngitis.Salix babylonica L. and contained chemical constituent thereof are not also having relevant report aspect treatment hyperuricemia disease and the gout.
Mahonia fortunei (Lindl.) Fedde is a Berberidaceae Mahonia fortunei (Lindl.) Fedde platymiscium Mahonia bealei (Fort.) Carr.
Mahonia bealei(Fort.) Carr. is used as medicine by (" national Chinese herbal medicine compilation ") with root, stem, leaf, contains berberine, palmatine (palmatine), jateorhizine (jatrorrhizine), magnoline chemical constituents such as (magnoflorine).The function of Folium Mahoniae is a nourishing YIN and clearing away heat, cures mainly pulmonary tuberculosis, flu.Root, stem have the function of heat-clearing and toxic substances removing, cure mainly bacillary dysentery, acute gastroenteritis, infectious hepatitis, pneumonia, pulmonary tuberculosis, bronchitis, laryngopharynx swelling and pain.Eye conjunctivitis is controlled in this medicine external, carbuncle furuncle and phyma poison, burn.Mahonia fortunei (Lindl.) Fedde and contained chemical constituent thereof are not also having relevant report aspect treatment hyperuricemia disease and the gout.
In the medicine of prevention involved in the present invention and treatment hyperuricemia and related complication thereof, Fructus Akebiae clearing away heat-damp and promoting diuresis, liver-smoothing, qi-regulating, blood circulation and channel invigorating, promoting the circulation of QI to relieve pain, diuresis parasite killing are monarch drug in the side; The Caulis et Folium fici Tikouae heat clearing away, dampness removing is invigorated blood circulation, and detoxifcation is monarch drug in the side; The two share, and reaches the function of clearing away heat-damp and promoting diuresis, diuresis of blood circulation promoting, and row gathers, ties the purpose of staying addiction admittedly by the six internal organs knot.Lignum seu Ramulus Cunninghamiae Lanceolatae records in Tang Materia Medica the earliest, and tool is warded off dirty, pain relieving, wet dissipation poison, the effect of subinverse gas; Willow belongs to the woody part low-grades in Shennong's Herbal, its bitter in the mouth is cold, cures mainly the edema due to wind pathogen, jaundice, and fever sensation of the face is black, heat-clearing and toxic substances removing again, expelling wind and removing dampness; The function of Folium Mahoniae is the heat clearing away tonify deficiency, and relieving cough and resolving phlegm cures mainly pulmonary tuberculosis hemoptysis, osteopyrexia and fever, dizziness and tinnitus, waist soreness, vexed, conjunctival congestion.The three cooperates monarch drug, is intended to attack, mends double executing, to reach the effect of uric acid content in treatment gout, the reduction blood.The present invention be the applicant on the basis of existing technology; With reference to the achievement of China's folk tradition medicine and pharmacology, in conjunction with the concentrating on studies and testing of applicant 20 years, the utilization differentiation of tcm is theoretical; Through multidisciplinary researches such as pharmacology, toxicology, pharmaceuticss, the science compatibility is prepared from.
In the Chinese medicine composition that the present invention discloses, all medical materials all pick up from the wild resource of China southwest, and adopt special processing method to be prepared from, and in the prevention of hyperuricemia and related complication thereof and treatment, are reported first.
In the method for preparing of the medicine of prevention of the present invention and treatment hyperuricemia and related complication thereof, following a few procedure is arranged usually:
1, draw materials: all medical materials replace the plant of taking from China southwest Miao ethnic group accumulation regions season in Xia Qiu, draw materials by recipe quantity, on the spot processing.In each prescription medical material of medicine, Fructus Akebiae is a Lardizabalaceae plant Caulis Akebiae
Akebia quinata(Thunb.) fruit of Decne., Caulis et Folium fici Tikouae are the moraceae plants Radix Pachyrhizi Erosi
Ficus TikouaBur. stem and leaf, Lignum seu Ramulus Cunninghamiae Lanceolatae are taken from the thorn China fir
Cunninghamia lanceolata(Lamb.) branch and leaf of Hook., Salix babylonica L. are willow
Salix babylonicaLinn. branch and leaf, Mahonia fortunei (Lindl.) Fedde is taken from Gaulis Mahoniae
Mahonia bealei(Fort.) leaf of Carr..
2, remove impurity: after drawing materials by recipe quantity, every flavor medical material individual processing, remove its silt that adheres to and non-impurity of the drug after, be cut into the segment of 10 centimeter length, place extraction vessel.
3, decoct: in extraction vessel, add 5～12 times of water gagings, heating decocts, and water vapour is derived the back condensation and placed, and collects volatile oil, keeps little and boils 30～90 minutes.Filter, collect fried liquid.Medical material adds 4～8 times of water gagings again, and heating decocts to boiling, and keeps little and boils 30～90 minutes, collects volatile oil.Filter, merge decocting liquid.Volatile oil merges to be placed.
4, concentrate: decocting liquid is put into efficient enrichment facility carry out concentrate under reduced pressure at low temperature, being concentrated to relative density is 1.05～1.2.
5, drying: concentrated solution is carried out dried,, obtain extract like decompression lyophilization, dry, the direct spray drying of low-temperature reduced-pressure, microwave drying.
6, medical material can directly be processed medicinal tea and water decoction; Also can extract and volatile oil be processed various dosage forms: oral and external preparation such as granule, tablet, pill, capsule, drop pill, oral liquid, tincture, dry syrup, syrup, Emulsion, powder, spray, lotion, suppository supply the patient to use.
The present invention has the following advantages:
1, compared with prior art, the effect of the present invention in diseases such as the urine that prevention and treatment hyperuricemia, gout, urine retention and multiple reason cause is not smooth is significantly higher than the medicine of similar listing product and existing bibliographical information.
2, all herb resources among the present invention are abundant, and it is convenient, with low cost to gather, and all medical materials do not have pesticide residues and heavy metal pollution all from wild kind.
3, the present invention does not contain the toxicity medical material, in the life-time service process, does not find any toxicity as yet.
4, the present invention processes easyly, does not use restricted solvent, and the pollution of the course of processing to environment and product self avoided in the production technology environmental protection.
The specific embodiment
Embodiment 1:
Press following prescription prescription: Fructus Akebiae 25 g, Caulis et Folium fici Tikouae 30 g, Lignum seu Ramulus Cunninghamiae Lanceolatae 15 g, Salix babylonica L. 20 g, Mahonia fortunei (Lindl.) Fedde 20 g.Medical material total amount behind the prescription is 440 kg, inserts in 10 tons of extraction pot after medical material is cleaned, and adds 4.4 tons of water, and merceration was steam heated to boiling after 120 minutes, protected to boil 120 minutes, collected volatile oil totally 2.2 L, and is subsequent use.Filter, filtrate for later use, filtering residue adds 4 tons of water again, under maintenance boiling condition, keeps 90 minutes, filters and collects filtrating, and filtering residue discards.Merging filtrate is concentrated into proportion 1.1～1.3 through efficient reflux, and one imitates temperature: 70～72 ℃ of (vacuums :-0.06～0.05 Mpa); Two imitate temperature: 62～64 ℃ (vacuum :-0.07～0.08 Mpa)).Concentrated solution spray-dried (steam pressure (0.39～0.4 Mpa), 203～205 ℃ of EATs, 98～106 ℃ of leaving air temps, feed liquor speed 34.57 ml, tower internal pressure (27～-30 pa)).Collect brown extract powder 17.01 kg, packing, airtight, damp proof moistureproof the preservation.Press crude drug and calculate, yield is 3.86%.
The extract and the volatile oil of preparation are processed granule, by following recipe quantity preparation.
Prescription:
Extract powder 3.6 g
Volatile oil 0.5 g
Cane sugar powder 6.1 g
Concentration expressed in percentage by weight 70 % ethanol are an amount of
Magnesium stearate 0.3 g
Preparation technology: the extract powder and the volatile oil of formula ratio are added the cane sugar powder mix homogeneously, and with concentration expressed in percentage by weight 95% ethanol water system soft material, 16 orders are granulated, and 60 ℃ of dryings are taken out back 16 order granulate, add the magnesium stearate mixing, and packing promptly gets.Every bag 10 gram.
Embodiment 2
Press following prescription prescription: Fructus Akebiae 30 g, Caulis et Folium fici Tikouae 30 g, Lignum seu Ramulus Cunninghamiae Lanceolatae 20 g, Salix babylonica L. 20 g.Medical material total amount behind the prescription is 400 kg, inserts in 10 tons of extraction pot after medical material is cleaned, and adds 4 tons in water, and merceration was steam heated to boiling after 120 minutes, protected to boil 120 minutes, collected volatile oil totally 1.8 L, and is subsequent use.Filter, filtrate for later use, filtering residue adds 4 tons of water again, under maintenance boiling condition, keeps 90 minutes, filters and collects filtrating, and filtering residue discards.Merging filtrate, (one imitates temperature: 70～72 ℃ of (vacuums :-0.06～0.05 Mpa) to be concentrated into proportion 1.1～1.3 through efficient reflux; Two imitate temperature: 62～64 ℃ (vacuum :-0.07～0.08 Mpa)).Concentrated solution spray-dried (steam pressure (0.39～0.4 Mpa), 203～205 ℃ of EATs, 98～106 ℃ of leaving air temps, feed liquor speed 34.57 ml, tower internal pressure (27～-30 pa)).Collect brown extract powder 20.4 kg, packing, airtight, damp proof moistureproof the preservation.Press crude drug and calculate, yield is 5.1%.
The preparation of tablet
The extract and the volatile oil of preparation are processed granule, by following recipe quantity preparation.
Prescription:
Extract powder 3.6g
Volatile oil 0.5g
Microcrystalline Cellulose 0.8g
Carboxymethyl starch sodium 0.4g
Concentration expressed in percentage by weight 75% alcoholic solution is an amount of
Magnesium stearate 0.2g
Preparation technology: take by weighing the recipe quantity extract powder, volatile oil, microcrystalline Cellulose; Carboxymethyl starch sodium, mix homogeneously in suitable container adds an amount of concentration expressed in percentage by weight 75% alcoholic solution system soft material; Cross 18 mesh sieves and granulate, with the mesh sieve granulate, add the recipe quantity magnesium stearate after 60 ℃ of aeration-dryings; Mix homogeneously, mixture are suppressed on tablet machine in flakes, and specification is the heavy 0.5g of every sheet.
Since nineteen ninety, the present invention is used for treatment of diseases such as urine that hyperuricemia, gout, urine retention and multiple reason cause is not smooth clinically for a long time, and extensive and deep clinical practice basis is arranged.According to the clinical case history record, totally 588 routine patient with gout and 575 routine urine retention patients have adopted oral this medicine to treat.The oral decoct of patient, 1～3 pair of every day, 3～6 pairs of continuous uses, 15 days is 1 course of treatment, carries out a blood uric acid check per course of treatment, observes continuously 2 months.
The result finds:
In the 716 routine patient with gout, the serum uric acid level of 314 examples returns back to normal value 350～417 mmol/L, does not return bullet after the drug withdrawal, and pain symptom disappears basically; The serum uric acid level of 125 examples reaches normal value 350～417 mmol/L after course of treatment of medication, but bullet is returned in drug withdrawal again after 2 months, and pain symptom alleviates or disappear; The serum uric acid level of 102 examples reaches normal value 300～417 mmol/L after course of treatment of medication, but bullet is returned in drug withdrawal again after 2 months, and the serum uric acid level value surpasses 417 mmol/L, and occurs pain symptom once more; 75 examples are invalid, and serum uric acid level and gout symptom do not alleviate, and therefore, the total effective rate of this Drug therapy hyperuricemia disease and gout is 89.5%.
In addition, this medicine is not found any toxic and side effects as yet in the life-time service process, hyperuricemia disease, gout and urine retention are also had tangible preventive effect.
Kweiyang retired cadre Mr. Zhang, 72 years old, long-term dysuria, each urine all need be used hand steered wall.Be diagnosed as the urine retention that hyperuricemia disease causes, the hematuria acid number is 612.Clinician is left the granule of embodiment 1, three times on the one, each two bags, takes after mixing it with hot water.The patient takes two courses of treatment, and after totally six days, the beginning of urinating is smooth and easy, requires again to add three courses of treatment, has thoroughly solved the not smooth misery of urinating for many years, and the hematuria acid number after the further consultation is 482, does not see bounce-back so far.
Chengdu Railway Bureau worker Mrs Ceng, 38 years old, health check-up found that uric acid level reaches 648, and has formed metabolic arthritis renal calculus.Clinician is left the tablet of embodiment 2, three times on the one, each 3, takes after mixing it with hot water.After taking three courses of treatment, uric acid level returns to 382 normal value standard, fails to find calculus after the further consultation.
Yunnan driver Mr. Deng, man 58 years old because of carrier characteristics all the year round, causes uric acid level to exceed standard and urinates not freely for a long time, and uric acid level reaches 631.Clinician is left the granule of embodiment 1, three times on the one, each two bags, takes after mixing it with hot water.After the patient took five courses of treatment, uric acid level returned to 394 arm's length standard, and it is also very unobstructed to urinate, and in order to consolidate curative effect, required to add three courses of treatment.
Certain senior executive Mrs Xiong of foreign enterprise, 47 years old, health check-up found that uric acid level reaches 612, and has formed metabolic arthritis renal calculus, kidney portion pain unbearably, an eye gland also has calculus to form, and takes chemicals for a long time, the course of disease repeatedly, attention is difficult to concentrate.Clinician is left the tablet of embodiment 2, three times on the one, each 4, takes after mixing it with hot water.After taking three courses of treatment, uric acid level returns to 362 normal value, and pain symptom is eliminated, and fails to find calculus after the further consultation, and the later stage further consultation does not see that calculus forms yet.
Claims (7)
1. treat the Chinese medicine composition of hyperuricemia disease, gout and urine retention, it is characterized in that it is to be processed by the raw material that comprises following weight portion:
Fructus Akebiae 20-60
Caulis et Folium fici Tikouae 20-60
Lignum seu Ramulus Cunninghamiae Lanceolatae 10-50
Salix babylonica L. 15-50.
2. Chinese medicine composition according to claim 1 is characterized in that it is processed by the raw material of following weight portion:
Mahonia fortunei (Lindl.) Fedde 15-50.
3. Chinese medicine composition according to claim 1 is characterized in that it is processed by the raw material of following weight portion:
Fructus Akebiae 30
Caulis et Folium fici Tikouae 30
Lignum seu Ramulus Cunninghamiae Lanceolatae 20
Salix babylonica L. 20.
4. Chinese medicine composition according to claim 2 is characterized in that it is processed by the raw material of following weight portion:
Fructus Akebiae 25
Caulis et Folium fici Tikouae 30
Lignum seu Ramulus Cunninghamiae Lanceolatae 15
Salix babylonica L. 10
Mahonia fortunei (Lindl.) Fedde 20.
5. according to the described Chinese medicine composition of claim 1～4, it is characterized in that raw material is added 5～16 times of water gagings, heating decocts, and collects volatile oil; Keep little and boiled 30～120 minutes, filter, collect fried liquid, medicinal residues add 4～12 times of water gagings again; Heating decocts to boiling, and keeps little and boils 30～120 minutes, collects volatile oil; Filter, collect fried liquid, merge fried liquid; Volatile oil merges to be placed; Fried liquid is concentrated after drying, obtain extract solid, volatile oil and extract are processed Chinese patent medicine as raw material.
6. according to claim 1 or 3 described Chinese medicine pharmaceutical compositions, it is characterized in that raw material is added 12 times of water gagings, heating decocts, and derives steam; Collect upper strata volatile oil after the condensation, keep little and boiled 90 minutes, filter, collect fried liquid; Medicinal residues add 10 times of water gagings again, and heating decocts to boiling, and keep little and boil 60 minutes, collect volatile oil; Filter, collect fried liquid, merge fried liquid; Volatile oil merges the back and adds anhydrous sodium sulfate drying, places in 4 ℃ of following low temperature; It is 1.16 that fried liquid is evaporated to relative density in 60 ℃; Import spray drying device; In feed liquor speed is that 30 ml/min, EAT are to carry out drying under 120 ℃ the condition, collects pale yellow pressed powder, and volatile oil and pale yellow pressed powder are processed Chinese patent medicine as raw material.
7. Chinese medicine composition according to claim 1 is characterized in that being medicinal tea or water decoction or granule or tablet or pill or capsule or drop pill or oral liquid or tincture or dry syrup or syrup or Emulsion or powder or spray or lotion or suppository.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940850A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating gout |
| CN105535708A (en) * | 2015-12-25 | 2016-05-04 | 济南邦文医药科技有限公司 | Medicinal composition for treating postoperative uroschesis of lung-heat congestion type anorectal diseases |
| CN105661528A (en) * | 2016-02-29 | 2016-06-15 | 青鼎木（武汉）生物科技有限公司 | Special diet plant beverage suitable for patients suffering from hyperuricemia and gout |
| CN106942578A (en) * | 2017-03-08 | 2017-07-14 | 杨涵 | A kind of natural meals for controlling purine intake and promoting uric acid excretion |
| WO2019127036A1 (en) * | 2017-12-26 | 2019-07-04 | 刘继勇 | Traditional chinese medicine composition for preventing and treating lithiasis, hyperuricemia, gout and complications thereof, preparation method therefor, and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122240A (en) * | 1995-08-08 | 1996-05-15 | 张振礼 | Medicine for lithiasis and its preparing method |
| CN1260202A (en) * | 1999-08-30 | 2000-07-19 | 张振礼 | Medicament for treating urinary calculus and its preparation method |
| CN102091248A (en) * | 2011-01-18 | 2011-06-15 | 刘继勇 | Vegetable medicament formula for preventing and treating all kinds of calculosis and preparation method thereof |
-
2012
- 2012-02-15 CN CN2012100327584A patent/CN102579658A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122240A (en) * | 1995-08-08 | 1996-05-15 | 张振礼 | Medicine for lithiasis and its preparing method |
| CN1260202A (en) * | 1999-08-30 | 2000-07-19 | 张振礼 | Medicament for treating urinary calculus and its preparation method |
| CN102091248A (en) * | 2011-01-18 | 2011-06-15 | 刘继勇 | Vegetable medicament formula for preventing and treating all kinds of calculosis and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940850A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating gout |
| CN102940850B (en) * | 2012-10-31 | 2014-03-19 | 成都医路康医学技术服务有限公司 | Medicine composition for treating gout |
| CN105535708A (en) * | 2015-12-25 | 2016-05-04 | 济南邦文医药科技有限公司 | Medicinal composition for treating postoperative uroschesis of lung-heat congestion type anorectal diseases |
| CN105661528A (en) * | 2016-02-29 | 2016-06-15 | 青鼎木（武汉）生物科技有限公司 | Special diet plant beverage suitable for patients suffering from hyperuricemia and gout |
| CN106942578A (en) * | 2017-03-08 | 2017-07-14 | 杨涵 | A kind of natural meals for controlling purine intake and promoting uric acid excretion |
| WO2019127036A1 (en) * | 2017-12-26 | 2019-07-04 | 刘继勇 | Traditional chinese medicine composition for preventing and treating lithiasis, hyperuricemia, gout and complications thereof, preparation method therefor, and application thereof |
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Application publication date: 20120718 |