CN101757460A - Traditional Chinese medicine preparation for treating gout - Google Patents
Traditional Chinese medicine preparation for treating gout Download PDFInfo
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- CN101757460A CN101757460A CN200810240560A CN200810240560A CN101757460A CN 101757460 A CN101757460 A CN 101757460A CN 200810240560 A CN200810240560 A CN 200810240560A CN 200810240560 A CN200810240560 A CN 200810240560A CN 101757460 A CN101757460 A CN 101757460A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating gout, belonging to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine preparation is traditional Chinese medicine granules prepared from bighead atractylodes rhizome, golden cypress, the root of bidentate achyranthes, pseudo-ginseng, large-leaved gentian, caulis spatholobi, gastrodia elata, radix clematidis, radix.sileris and rhizoma alismatis. The traditional Chinese medicine preparation has the functions of clearing away heat, eliminating dampeness, eliminating stasis, activating meridian, reducing swelling and easing pain, is mainly used for treating gout and has no toxic and side effects. In order to better explain the benefit effects of the invention, pharmacodynamics experiment research is carried out for easing pain, resisting inflammation and reducing swelling, and the like, the result shows that the invention has the better functions of easing pain, resisting inflammation, reducing swelling, and the like.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine preparation for the treatment of gout.
Background technology
Gout is a kind of because disease that purine metabolic disturbance caused, and past China's sickness rate is lower, and along with the raising of people's living standard, gout has become commonly encountered diseases and frequently-occurring disease in recent years.Its clinical characters is hyperuricemia, gouty arthritis, joint deformity, nephropathy and urate calculus, the formation of gout calculus etc.Wherein the paranormal a kind of state of uric acid in the hyperuricemia is a stage in the gout evolution.The gout symptom is based on joint of the lower extremity red and swollen heat pain repeatedly, on differential diagnosis in tcm belongs to damp and hot numbness category more.Its pathogenesis or because of the natural endowment deficiency, or because of the day after tomorrow diet mend joint, visceral dysfunction, distinguish not turbid not normal, so wet, heat, the stasis of blood, the life thereupon of turbid all diseases.
Existing Western medicine is treated at the symptom selectivity that different times showed at patient with gout, be used for gout acute attack treatment as anti-inflammation analgesis medicament colchicine and indometacin, drainage uric acid medicine such as probenecid, benzbromarone are used for gap phase and chronic phase treatment, and it is synthetic that xanthine oxidase inhibitor medicine allopurinol is used to suppress uric acid.But the said medicine toxic and side effects is big, and the patient often can not adhere to taking for a long time, so that the wayward state of an illness.Toxicity as colchicine is bigger, common nausea,vomiting,diarrhea, stomachache, gastrointestinal reaction are serious prodromes of poisoning, drug withdrawal at once when symptom occurs, the visible hematuria of kidney damage, oliguria, to bone marrow direct repression arranged, cause agranulocytosis, aplastic anemia etc.; Indometacin can produce the GI irritation effect; Take probenecid, the visible gastrointestinal reaction of a few patients, erythra, heating, the treatment initial stage can make the gout outbreak increase the weight of; Benzbromarone has gastrointestinal reaction, renal colic and excites side effect such as gout acute attack; Take allopurinol, erythra, diarrhoea stomachache, low grade fever, temporary transaminase rising or granulocytopenia can appear in individual patients.
Therefore, need development and the little medicine of exploitation toxic and side effects.The defective that the present invention exists at existing medicine just provides a kind of pure Chinese medicinal preparation for the treatment of gout, proves that through preliminary test the present invention has effects such as analgesia, anti-inflammation detumescence preferably, is used for the treatment of gout and shows effect, and is evident in efficacy and have no side effect.
Summary of the invention
The invention provides a kind of Chinese medicine preparation of the evident in efficacy and treatment gout that has no side effect, purpose is to overcome the deficiency of existing medicine.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine preparation for the treatment of gout, it is that raw material is made by following parts by weight of Chinese traditional medicine material:
40～80 parts of 50～90 parts of Radix Achyranthis Bidentataes of 30～60 portions of Cortex Phellodendris of the Rhizoma Atractylodis Macrocephalae
30～70 parts of 35～65 portions of Caulis Spatholobis of 10～35 portions of Radix Gentianae Macrophyllae of Radix Notoginseng
30～60 parts of 40～80 parts of Radix Saposhnikoviaes of 20～75 parts of Radix Clematidis of Rhizoma Gastrodiae
35～65 parts of Rhizoma Alismatis
And the weight portion proportioning of described each Chinese crude drug raw material is:
60 parts of 70 parts of Radix Achyranthis Bidentataes of 45 portions of Cortex Phellodendris of the Rhizoma Atractylodis Macrocephalae
55 parts of 50 portions of Caulis Spatholobis of 20 portions of Radix Gentianae Macrophyllae of Radix Notoginseng
45 parts of 60 parts of Radix Saposhnikoviaes of 50 parts of Radix Clematidis of Rhizoma Gastrodiae
45 parts of Rhizoma Alismatis
The preparation method of this Chinese medicine preparation is:
(1) Cortex Phellodendri, Radix Achyranthis Bidentatae, Caulis Spatholobi, Rhizoma Gastrodiae are mixed, add 50～70% ethanol extractions 1～3 time, each 1～2 hour, filter (medicinal residues are stand-by), filtrate is condensed into the clear paste that relative density is 1.20～1.24 (50～60 ℃), and is standby;
(2) get Six-elements such as all the other Rhizoma Atractylodis Macrocephalaes, Radix Notoginseng, confuse above-mentioned alcohol extraction medicinal residues, decoct with water 2～5 times, each 1～3 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.18～1.22 (60～80 ℃), and is standby;
(3) above-mentioned two standby clear paste are mixed stir evenly, add ethanol and make and contain the alcohol amount and reach 40～60% (V/V), cold preservation was left standstill 4～8 hours, get supernatant, decompression recycling ethanol is not distinguished the flavor of to there being alcohol, and is condensed into the thick paste that relative density is 1.30～1.36 (60～70 ℃), and is standby;
(4) get the thick paste that makes, it is an amount of to add cane sugar powder and starch or dextrin, and mixing, drying under reduced pressure become dried cream, are ground into fine powder, and water or 60～90% ethanol are made granule, drying, and granulate, packing, promptly.
Function of the present invention cures mainly and is: clearing away heat and eliminating dampness, eliminating blood stasis and smoothing collaterals, reducing swelling and alleviating pain are mainly used in the treatment of gout.
For beneficial effect of the present invention better is described, we have carried out analgesic test, anti-inflammation detumescence experimental study, and with the bloated effect of analgesia, anti-inflammation detumescence of having observed granule of the present invention, it thes contents are as follows:
Principal agent side: Rhizoma Atractylodis Macrocephalae 45g, Cortex Phellodendri 70g, Radix Achyranthis Bidentatae 60g, Radix Notoginseng 20g, Radix Gentianae Macrophyllae 50g, Caulis Spatholobi 55g, Rhizoma Gastrodiae 50g, Radix Clematidis 60g, Radix Saposhnikoviae 45g, Rhizoma Alismatis 45g makes granule according to preparation method of the present invention.
One, analgesic test
The test of 1 writhing method
1.1 material granule of the present invention; Indometacin; Kunming mouse 18～22g, the male and female dual-purpose; 0.6% acetic acid etc.
1.2 the method mice is divided into four groups at random, 12 every group.The blank group is irritated stomach 0.2ml/10g distilled water, indometacin group (0.021g/kg), granule high dose group of the present invention (7g/kg), low dose group (3.5g/kg).Four groups of mice ig every day administration 1 time, totally 7 days, only inject 0.6% acetum 0.2ml/ in 60 minutes pneumoretroperitoneums of administration in the 7th day, observe every mice and cause the time of turning round body because of pain for the first time.
1.3 the results are shown in Table 1.
Table 1 granule of the present invention to mice acetic acid cause the pain turn round body influence the result (x ± s, n=12)
Annotate: compare * P＜0.05, * * P＜0.01 with matched group
1.4 the mice of three groups of gastric infusions of conclusion all has in various degree to prolong the average time that writhing response occurs.Indometacin group and high dose granule group of the present invention and distilled water group relatively have highly significant difference (P＜0.01); More also there were significant differences (P＜0.05) for low dosage granule group of the present invention and distilled water group.Illustrate that granule of the present invention has obvious inhibition acetic acid (chemical substance stimulation) to cause the effect of mice pain, and high dose granule effect of the present invention is better than the indometacin group.
The test of 2 hot plate methods
2.1 material Kunming mouse 18～22g is female; Indometacin; Granule of the present invention etc.
2.2 method is regulated 55 ℃ ± 1 ℃ of constant temperature with water bath, puts a large beaker and floats in the water, treat the permanent heat of beaker after, mice is dropped in the beaker, the record mice licks the sufficient time from dropping into beaker to the pain of being heated because of foot, as the pain threshold values of this Mus.Screening pain threshold values is divided into four groups at random 10～25 seconds mice, and mice group and processing method are same as writhing method.In the 7th day after administration 30 minutes, surveyed the pain threshold values of mice in 60 minutes respectively, observe the variation of pain threshold values before and after the administration.The control room temperature is 15～20 ℃ during test.
2.3 the results are shown in Table 2.
Table 2 granule of the present invention to the pain caused effect of mice hot plate method influence the result (x ± s, n=12)
Annotate: with blank group ratio, * * P＜0.01, * P＜0.05
2.4 the mice of three groups of gastric infusions of conclusion, after one week of administration, its pain threshold values all has in various degree and to improve, and 30 minutes the time, the effect of indometacin group is stronger behind the last medicine, with matched group P＜0.01 relatively; The effect of high dose granule group of the present invention is also stronger, with matched group than P＜0.05; Though and the pain threshold values of granule low dose group of the present invention has and increases, significance not as yet.And 60 minutes three groups of administration group pain threshold values are significantly increased behind the medicine, than all significant difference are arranged with matched group, P＜0.05, P＜0.01.Effect weakened slightly when wherein the indometacin group was than 30 minutes, and the effect of two granule groups of the present invention is strengthened during all than 30 minutes.Illustrate that indometacin and granule of the present invention all have the effect of better inhibition mice because of thermic pain (physics causes pain), and the analgesic activity of granule of the present invention is lasting than relaxing, and hysteresis is arranged.
Two, anti-inflammation detumescence test
The test of 1 rat paw edema
1.1 material granule of the present invention; Prednisolone acetate; SD rat 150～200g, male and female half and half; 3% formaldehyde; Pentobarbital sodium etc.
1.2 method is divided into four groups at random with rat, 10 every group, is respectively blank group, prednisolone acetate group, granule high and low dose group of the present invention.Rat after 30 minutes, causes inflammation (every 0.1ml) with sufficient sole of the foot of 3% formaldehyde injection in administration in the morning in the 10th day according to different pharmaceutical concentration ig administration 10 days, measures and causes first and second natural feet sole of the foot diameter of scorching back, and the difference of left and right sides diameter is the swelling degree.
1.3 the results are shown in Table 3
Table 3 granule of the present invention to the influence of rat paw edema (x ± s, n=10)
Annotate: with blank group ratio, * P＜0.05
1.4 the conclusion rat causes scorching back first day at formaldehyde, three administration group pedal swelling degree are all light than the blank group, wherein prednisolone acetate group and granule high dose group swelling degree of the present invention be significantly less than blank group (P＜0.05), and granule low dose group swelling degree of the present invention reduces as yet not significance.The foot sole of the foot causes scorching back second day, and three administration group swelling degree still all are lower than matched group, but have only granule high dose group significance of the present invention (P＜0.05).The research prompting: granule high dose of the present invention is stronger than prednisolone acetate resist inflammation on repercussive function, and the action time of granule of the present invention is long than prednisolone acetate.
The swollen test of 2 rat granulomas
2.1 material SD rat (the same), cotton balls (10mg), prednisolone acetate, 1% pentobarbital sodium, photoelectric analytical balance, granule of the present invention.
2.2 method is divided into four groups at random with the SD rat, 10 every group, is respectively the blank group, prednisolone acetate group, granule high and low dose group of the present invention.Under pentobarbital sodium anesthesia, a longitudinal incision is done at Mus back of the body median line by the sterile working, and sterilized cotton balls is implanted in the otch of back, sews up.Each is organized dosage listed in the rat according to the form below and begins the ig administration the previous day from performing the operation, once a day.Continuous 7 days, in the 8th day with the rat sacrificed by decapitation, peel off the back otch and take out the cotton balls granulation tissue, behind 60～90 ℃ of baking oven inner drying 1h, weigh, deduct the raw cotton ball weight, be the granuloma net weight.
2.3 the results are shown in Table 4.
Table 4 granule of the present invention to the bullate effect of rat granuloma (x ± s, n=10)
Annotate: compare * * P＜0.01 with the blank group
2.4 conclusion and blank group are relatively, three equal highly significants of administration group granuloma net weight reduce (P＜0.01), and effect is better than the prednisolone acetate group.
The test of 3 capillary permeabilities
3.1 material Kunming mouse 18～22g, the male and female dual-purpose; Azovan blue; Spectrophotometer; Indometacin; Granule of the present invention; Histamine etc.
3.2 method is divided into four groups at random with mice.Every group 10, be respectively blank group, indometacin group, granule high and low dose group of the present invention.Each group is by dosage ig administration in the table, and shared medicine 6 days in the histamine 0.1ml of the 6th day intraperitoneal injection in 40 minutes 1 μ g/ml after the ig administration, and promptly from tail vein injection 1% azovan blue 4ml/kg, takes off neck and puts to death mice after 30 minutes, cut the abdominal cavity open.And the azovan blue that oozes out with 10ml normal saline flushing abdominal cavity.Centrifugal, supernatant is measuring light density (0D) under the 590nm with spectrophotometer at wavelength.
3.3 the results are shown in Table 5.
Table 5 granule of the present invention to mouse peritoneal azovan blue transudation (x ± s, n=10)
Annotate: compare * P＜0.05 with the blank group
3.4 conclusion is with the blank group relatively, the optical density of granule high dose group of the present invention and indometacin group has remarkable reduction, and low dosage is obeyed peaceful group bitterly reduction trend is arranged, but significance not as yet.Illustrate that granule of the present invention has the effect that certain inhibition proinflammatory factors causes that vascular permeability increases, the high more effect of dosage is obvious more.
Three, sum up
We adopt physics to cause pain, chemistry causes model contrasts such as pain, formaldehyde pedal swelling, granuloma induced by implantation of cotton pellets and capillary permeability, observed the bloated effect of analgesia, anti-inflammation detumescence of granule of the present invention, the result shows that the present invention has analgesia, resist inflammation on repercussive function preferably, and the high more effect of dosage is remarkable more.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
Embodiment 1:
Adopt following prescription:
Rhizoma Atractylodis Macrocephalae 45g Cortex Phellodendri 70g Radix Achyranthis Bidentatae 60g
Radix Notoginseng 20g Radix Gentianae Macrophyllae 50g Caulis Spatholobi 55g
Rhizoma Gastrodiae 50g Radix Clematidis 60g Radix Saposhnikoviae 45g
Rhizoma Alismatis 45g
Preparation method is:
(1) with Cortex Phellodendri 70g, Radix Achyranthis Bidentatae 60g, Caulis Spatholobi 55g, Rhizoma Gastrodiae 50g, mix, add 60% ethanol extraction 3 times, each 1 hour, filter (medicinal residues are stand-by), filtrate is condensed into the clear paste that relative density is 1.22 (55 ℃), and is standby;
(2) get Six-elements such as all the other Rhizoma Atractylodis Macrocephalaes, Radix Notoginseng, confuse above-mentioned alcohol extraction medicinal residues, decoct with water 4 times, each 1 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.20 (70 ℃), and is standby;
(3) above-mentioned two standby clear paste are mixed stir evenly, add ethanol and make and contain the alcohol amount and reach 50% (V/V), cold preservation was left standstill 6 hours, got supernatant, and decompression recycling ethanol is not to there being the alcohol flavor, and was condensed into the thick paste that relative density is 1.34 (70 ℃), and is standby;
(4) get the thick paste that makes, add the about 52g of cane sugar powder, the about 124g of starch, mixing, drying under reduced pressure become dried cream, are ground into fine powder, and water is made granule, drying, granulate, packing, promptly.
Embodiment 2:
Adopt following prescription:
Rhizoma Atractylodis Macrocephalae 30g Cortex Phellodendri 55g Radix Achyranthis Bidentatae 50g
Radix Notoginseng 10g Radix Gentianae Macrophyllae 40g Caulis Spatholobi 50g
Rhizoma Gastrodiae 20g Radix Clematidis 50g Radix Saposhnikoviae 30
Rhizoma Alismatis 40g
Preparation method is:
(1) with Cortex Phellodendri 55g, Radix Achyranthis Bidentatae 50g, Caulis Spatholobi 50g, Rhizoma Gastrodiae 20g, mix, add 70% ethanol extraction 2 times, each 1 hour, filter (medicinal residues are stand-by), filtrate is condensed into the clear paste that relative density is 1.24 (50 ℃), and is standby;
(2) get Six-elements such as all the other Rhizoma Atractylodis Macrocephalaes, Radix Notoginseng, confuse above-mentioned alcohol extraction medicinal residues, decoct with water 3 times, each 1 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.22 (60 ℃), and is standby;
(3) above-mentioned two standby clear paste are mixed stir evenly, add ethanol and make and contain the alcohol amount and reach 40% (V/V), cold preservation was left standstill 4 hours, got supernatant, and decompression recycling ethanol is not to there being the alcohol flavor, and was condensed into the thick paste that relative density is 1.35 (60 ℃), and is standby;
(4) get the thick paste that makes, add the about 22g of cane sugar powder, the about 66g of dextrin, mixing, drying under reduced pressure become dried cream, are ground into fine powder, make granule with 70% ethanol, drying, granulate, packing, promptly.
Embodiment 3:
Adopt following prescription:
Rhizoma Atractylodis Macrocephalae 60g Cortex Phellodendri 80g Radix Achyranthis Bidentatae 80g
Radix Notoginseng 30g Radix Gentianae Macrophyllae 60g Caulis Spatholobi 70g
Rhizoma Gastrodiae 70g Radix Clematidis 70g Radix Saposhnikoviae 60g
Rhizoma Alismatis 65g
Preparation method is:
(1) with Cortex Phellodendri 80g, Radix Achyranthis Bidentatae 80g, Caulis Spatholobi 70g, Rhizoma Gastrodiae 70g, mix, add 50% ethanol extraction 3 times, each 1.5 hours, filter (medicinal residues are stand-by), filtrate is condensed into the clear paste that relative density is 1.20 (60 ℃), and is standby;
(2) get Six-elements such as all the other Rhizoma Atractylodis Macrocephalaes, Radix Notoginseng, confuse above-mentioned alcohol extraction medicinal residues, decoct with water 2 times, each 2 hours, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃), and is standby;
(3) above-mentioned two standby clear paste are mixed stir evenly, add ethanol and make and contain the alcohol amount and reach 60% (V/V), cold preservation was left standstill 8 hours, got supernatant, and decompression recycling ethanol is not to there being the alcohol flavor, and was condensed into the thick paste that relative density is 1.32 (70 ℃), and is standby;
(4) get the thick paste that makes, it is an amount of to add cane sugar powder and starch or dextrin, and mixing, drying under reduced pressure become dried cream, are ground into fine powder, and water or 60～90% ethanol are made granule, drying, and granulate, packing, promptly.
(5) get the thick paste that makes, add the about 77g of cane sugar powder, the about 124g of starch, the about 55g of dextrin, mixing, drying under reduced pressure become dried cream, are ground into fine powder, make granule with 85%, drying, granulate, packing, promptly.
Claims (3)
1. Chinese medicine preparation for the treatment of gout is characterized in that it is that raw material is made by following parts by weight of Chinese traditional medicine material:
40～80 parts of 50～90 parts of Radix Achyranthis Bidentataes of 30～60 portions of Cortex Phellodendris of the Rhizoma Atractylodis Macrocephalae
30～70 parts of 35～65 portions of Caulis Spatholobis of 10～35 portions of Radix Gentianae Macrophyllae of Radix Notoginseng
30～60 parts of 40～80 parts of Radix Saposhnikoviaes of 20～75 parts of Radix Clematidis of Rhizoma Gastrodiae
35～65 parts of Rhizoma Alismatis.
2. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, wherein the weight portion proportioning of each Chinese crude drug raw material is:
60 parts of 70 parts of Radix Achyranthis Bidentataes of 45 portions of Cortex Phellodendris of the Rhizoma Atractylodis Macrocephalae
55 parts of 50 portions of Caulis Spatholobis of 20 portions of Radix Gentianae Macrophyllae of Radix Notoginseng
45 parts of 60 parts of Radix Saposhnikoviaes of 50 parts of Radix Clematidis of Rhizoma Gastrodiae
45 parts of Rhizoma Alismatis.
3. according to the Chinese medicine preparation of any treatment gout of claim 1-2, its preparation method is:
(1) Cortex Phellodendri, Radix Achyranthis Bidentatae, Caulis Spatholobi, Rhizoma Gastrodiae are mixed, add 50～70% ethanol extractions 1～3 time, each 1～2 hour, filter (medicinal residues are stand-by), filtrate is condensed into the clear paste that relative density is 1.20～1.24 (50～60 ℃), and is standby;
(2) get Six-elements such as all the other Rhizoma Atractylodis Macrocephalaes, Radix Notoginseng, confuse above-mentioned alcohol extraction medicinal residues, decoct with water 2～5 times, each 1～3 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.18～1.22 (60～80 ℃), and is standby;
(3) above-mentioned two standby clear paste are mixed stir evenly, add ethanol and make and contain the alcohol amount and reach 40～60% (V/V), cold preservation was left standstill 4～8 hours, get supernatant, decompression recycling ethanol is not distinguished the flavor of to there being alcohol, and is condensed into the thick paste that relative density is 1.30～1.36 (60～70 ℃), and is standby;
(4) get the thick paste that makes, it is an amount of to add cane sugar powder and starch or dextrin, and mixing, drying under reduced pressure become dried cream, are ground into fine powder, and water or 60～90% ethanol are made granule, drying, and granulate, packing, promptly.
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| CN200810240560A CN101757460A (en) | 2008-12-23 | 2008-12-23 | Traditional Chinese medicine preparation for treating gout |
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| CN200810240560A CN101757460A (en) | 2008-12-23 | 2008-12-23 | Traditional Chinese medicine preparation for treating gout |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920024A (en) * | 2014-05-04 | 2014-07-16 | 李万水 | Medicinal preparation for treating gout and preparation method thereof |
| CN113813342A (en) * | 2021-09-11 | 2021-12-21 | 河南诚朴生物科技有限公司 | Medicine for treating gout and preparation method thereof |
-
2008
- 2008-12-23 CN CN200810240560A patent/CN101757460A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920024A (en) * | 2014-05-04 | 2014-07-16 | 李万水 | Medicinal preparation for treating gout and preparation method thereof |
| CN113813342A (en) * | 2021-09-11 | 2021-12-21 | 河南诚朴生物科技有限公司 | Medicine for treating gout and preparation method thereof |
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Open date: 20100630 |