CN101524447A - Pharmaceutical composition for treating constipation and preparation process thereof - Google Patents
Pharmaceutical composition for treating constipation and preparation process thereof Download PDFInfo
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- CN101524447A CN101524447A CN200810101480A CN200810101480A CN101524447A CN 101524447 A CN101524447 A CN 101524447A CN 200810101480 A CN200810101480 A CN 200810101480A CN 200810101480 A CN200810101480 A CN 200810101480A CN 101524447 A CN101524447 A CN 101524447A
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Abstract
The invention discloses a pharmaceutical composition for treating constipation and a preparation process thereof. The pharmaceutical composition is prepared by taking senna leaf, hemp fruit, black sesame, natrii sulfas exsiccatus, white paeony root, flower of Japanese pagodatree, mulberry leaf, trifoliate akebia, herba schizonepetae, and oriental waterplantain rhizome in proportion by weight, and can be prepared into any common preparation for oral administration which comprises granules, capsules, pills, tablets, and the like. The medicament of the invention can effectively treat the constipation, can relieve abdominal pain and bloating caused by the constipation, ensures that symptoms of the constipation are disappeared, and has the advantages of short treatment course, quick response, and no side effects; moreover, the recurrence of the constipation cannot be caused by stopping taking the medicament, and the medicament is a preferred effective medicament for treating the constipation; and the medicament has obvious curative effects on blood deficiency and intestinal dry, relaxing bowel, abdominal fullness and distention, and promotion of excretion.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, relate to a kind of formula combination and preparation technology of Chinese medicine, be specifically related to a kind of drug regimen and preparation technology thereof who treats constipation.
Technical background
Constipation is that moisture is absorbed by intestinal wall in a large number because feces overstays at enteral, and the excrement piece becomes stiff, so that times of defecation minimizing, constipation with dry stool, discharge difficulty or not to the utmost.General do not have defecation more than two days, can point out constipation to exist.If equal bowel movement every day, just but still have residual sense behind difficult defecation and the defecation, or, also should include the scope of constipation in abdominal distention.
The reason great majority that cause constipation are old, malnutrition, and abdominal muscle, the unable contraction of levator ani m. lack cellulose in the feed, water deficient, the outer oncothlipsis intestinal of intestinal, anorectum illness etc.Its main clinical manifestation is that constipation with dry stool is difficult to resolve or a few days is not understood, and can be with headache, dizziness, loss of appetite, tired, abdominal distention, stomachache, even heating etc.In addition, because life or diet are irregular, meals meticulous (less crude fibre) lack physical exertion, often take the medicine (as calm, the medicine of sleeping) that influence enterokinesia and cause enterokinesia strength more weak or lose normal defecation reflex, also cause constipation easily.Just can " cure " constipation but among this part patient, some is a mistake property, passes through and adjusts rule of life, increase dietary fiber, set up the defecation trained reflex.
For the treatment constipation, most people generally are the methods that adopts some dietetic therapies earlier, when worse comes to worst, can eat a little medicines.Cathartic commonly used can be divided into following several by its model of action difference: first kind is " osmotic laxative ", as magnesium sulfate, sodium sulfate, after taking, medicine forms hyperosmotic state at enteral, this medicine absorb body fluids on the one hand enters intestinal, also stops the absorption of enteral moisture on the one hand, and the intestinal contents volume increases like this, stimulate the intestinal tube wriggling, promote defecation.Second kind is " irritant laxative ", and as phenolphthalein etc., this medicine stimulates intestinal wall by itself or its catabolite, increases enterokinesia, promotes defecation.The third is " emollient laxative ", and as Oleum Ricini, liquid paraffin, by lubricious intestinal wall, softening feces promotes defecation.The treatment of constipation should be selected said medicine for use in conjunction with individual instances.Health is good, and the constipation patient that the short time occurs can select first and second class cathartic for use, and health is not good enough, and is older, can select the 3rd class cathartic for use, adds in case of necessity and uses the motivator medicine.
Though above-mentioned cathartic has the promotion defecation, often form medicine by cathartic separately and rely on, even after taking a period of time medicine, effect is bad, has to use instead other cathartic.Correct method is to adjust life and dietary habit, forming on the basis of defecation trained reflex, be aided with cathartic and just can obtain curative effect preferably.
Under this background, medicine of the present invention arises at the historic moment, through the preferred agents combination, adopt rational preparation technology to extract the pure Chinese medicinal preparation that processes, can effectively treat constipation, short treating period, instant effect, have no side effect, can alleviate the abdominal pain and distension that brings because of constipation, the constipation transference cure, and can be because of this medicine of stopping using, the constipation recurrence, so it is the first-selected good medicine of treatment constipation.
Summary of the invention
The object of the invention is to provide a kind of drug regimen and preparation technology thereof who treats constipation, with developing target market, remedies the defective of existing medicine.
Be achieved through the following technical solutions order of the present invention:
1, the present invention is the preparation of being made by the following weight proportion raw material:
Folium Sennae 50-150 part Fructus Cannabis 30-120 part Semen Sesami Nigrum 20-100 part
Matrii Sulfas Exsiccatus 20-100 part Radix Paeoniae Alba 20-100 part Flos Sophorae 30-120 part
Folium Mori 20-100 part Caulis Akebiae 20-100 part Herba Schizonepetae 50-150 part
Rhizoma Alismatis 20-100 part
2, the present invention is the preparation of being made by following optimum weight proportion raw material:
60 parts of 80 portions of Semen Sesami Nigrums of 100 parts of Fructus Cannabiss of Folium Sennae
80 parts in 60 parts of Flos Sophoraes of 60 portions of Radix Paeoniae Albas of Matrii Sulfas Exsiccatus
100 parts of 60 parts of Herba Schizonepetaes of 60 portions of Caulis Akebiaes of Folium Mori
60 parts of Rhizoma Alismatis
3, preparation method:
(1) get the Radix Paeoniae Alba and be ground into fine powder, standby;
(2) get nine flavors such as all the other Folium Sennae, Fructus Cannabis, be mixed in proportion, decoct with water three times, the decocting that adds for the first time 8~12 times of medical material amounts boiled 2 hours, and the decocting that adds 6~10 times of medical material amounts for the second time boiled 1 hour, and the decocting that adds 6~8 times of medical material amounts for the third time boiled 1 hour, merge decocting liquid, leave standstill, filter, filtrate is concentrated into the thick paste that relative density is 1.35~1.39 (65~85 ℃), after the cold drying, be ground into fine powder, add Radix Paeoniae Alba fine powder then, mixing, standby;
(3) molding: it is an amount of 1. to add lactose, mixing, and with 85~95% alcohol granulations, drying is made granule, promptly gets granule.2. add an amount of lactose, make granule, incapsulate, promptly get capsule with 90~100% ethanol; 3. every 100g powder adds refined honey 40~50g and an amount of water, general ball, and drying is made water-honeyed pill; Or every 100g powder adds refined honey 110~120g and makes big honeyed pills, in dry below 60 ℃, promptly gets pill; 4. add 1~3% magnesium stearate, make granule, drying, compacting promptly gets tablet in flakes.
The present invention is to be raw material by each Chinese crude drug, and the oral preparations commonly used that is prepared from according to a certain weight ratio comprises granule, capsule, pill, tablet etc.It can effectively treat constipation, short treating period, instant effect, has no side effect, and can alleviate the abdominal pain and distension that brings because of constipation, the constipation transference cure, and can be because of this medicine of stopping using, the constipation recurrence.It is the first-selected good medicine of treatment constipation.Its drainage to blood deficiency dryness of the intestine, the relieving constipation of profit soup, distension and fullness in the abdomen, promotion stool all has significant curative effect.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
Embodiment 1:
1, adopt following prescription:
Folium Sennae 100g Fructus Cannabis 80g Semen Sesami Nigrum 60g
Matrii Sulfas Exsiccatus 60g Radix Paeoniae Alba 60g Flos Sophorae 80g
Folium Mori 60g Caulis Akebiae 60g Herba Schizonepetae 100g
Rhizoma Alismatis 60g
2, preparation technology is:
(1) get the Radix Paeoniae Alba and pulverize, get fine powder 60g, standby;
(2) get nine flavors such as all the other Folium Sennae, Fructus Cannabis, be mixed in proportion, decoct with water three times, the decocting that adds for the first time 10 times of medical material amounts boiled 2 hours, and the decocting that adds 8 times of medical material amounts for the second time boiled 1 hour, and the decocting that adds 8 times of medical material amounts for the third time boiled 1 hour, merge decocting liquid, leave standstill, filter, filtrate is concentrated into the thick paste that relative density is 1.36 (80 ℃), after the cold drying, be ground into fine powder, add Radix Paeoniae Alba fine powder then, mixing, standby;
(3) molding: add the about 210g of lactose, mixing is used 85% alcohol granulation, and drying is made granule, promptly gets granule.
Embodiment 2:
1, adopt following prescription:
Folium Sennae 80g Fructus Cannabis 60g Semen Sesami Nigrum 50g
Matrii Sulfas Exsiccatus 50g Radix Paeoniae Alba 50g Flos Sophorae 60g
Folium Mori 50g Caulis Akebiae 50g Herba Schizonepetae 80g
Rhizoma Alismatis 50g
2, preparation technology is:
(1) get the Radix Paeoniae Alba and pulverize, get fine powder 50g, standby;
(2) get nine flavors such as all the other Folium Sennae, Fructus Cannabis, be mixed in proportion, decoct with water three times, the decocting that adds for the first time 8 times of medical material amounts boiled 2 hours, and the decocting that adds 8 times of medical material amounts for the second time boiled 1 hour, and the decocting that adds 6 times of medical material amounts for the third time boiled 1 hour, merge decocting liquid, leave standstill, filter, filtrate is concentrated into the thick paste that relative density is 1.35 (70 ℃), after the cold drying, be ground into fine powder, add Radix Paeoniae Alba fine powder then, mixing, standby;
(3) molding: add the about 180g of lactose, make granule, incapsulate, promptly get capsule with 90% ethanol.
Embodiment 3:
1, adopt following prescription:
Folium Sennae 150g Fructus Cannabis 120g Semen Sesami Nigrum 100g
Matrii Sulfas Exsiccatus 100g Radix Paeoniae Alba 100g Flos Sophorae 120g
Folium Mori 100g Caulis Akebiae 100g Herba Schizonepetae 150g
Rhizoma Alismatis 100g
2, preparation technology is:
(1) get the Radix Paeoniae Alba and pulverize, get fine powder 100g, standby;
(2) get nine flavors such as all the other Folium Sennae, Fructus Cannabis, be mixed in proportion, decoct with water three times, the decocting that adds for the first time 10 times of medical material amounts boiled 2 hours, and the decocting that adds 8 times of medical material amounts for the second time boiled 1 hour, and the decocting that adds 6 times of medical material amounts for the third time boiled 1 hour, merge decocting liquid, leave standstill, filter, filtrate is concentrated into the thick paste that relative density is 1.38 (85 ℃), after the cold drying, be ground into fine powder, add Radix Paeoniae Alba fine powder then, mixing, standby;
(3) every 100g powder adds refined honey 40~50g and an amount of water, general ball, and drying is made water-honeyed pill, in dry below 60 ℃, promptly gets pill.
Embodiment 4:
1, adopt following prescription:
Folium Sennae 50g Fructus Cannabis 30g Semen Sesami Nigrum 20g
Matrii Sulfas Exsiccatus 20g Radix Paeoniae Alba 20g Flos Sophorae 30g
Folium Mori 20g Caulis Akebiae 20g Herba Schizonepetae 50g
Rhizoma Alismatis 20g
2, preparation technology is:
(1) get the Radix Paeoniae Alba and pulverize, get fine powder 20g, standby;
(2) get nine flavors such as all the other Folium Sennae, Fructus Cannabis, be mixed in proportion, decoct with water three times, the decocting that adds for the first time 8 times of medical material amounts boiled 2 hours, and the decocting that adds 6 times of medical material amounts for the second time boiled 1 hour, and the decocting that adds 6 times of medical material amounts for the third time boiled 1 hour, merge decocting liquid, leave standstill, filter, filtrate is concentrated into the thick paste that relative density is 1.37 (75 ℃), after the cold drying, be ground into fine powder, add Radix Paeoniae Alba fine powder then, mixing, standby;
(3) molding: the about 3g of magnesium stearate of adding 1%, make granule, drying, compacting promptly gets tablet in flakes.
Claims (3)
1, a kind of drug regimen for the treatment of constipation is characterized in that it is to be formed by the composition of raw materials of following weight by part:
Folium Sennae 50-150 part Fructus Cannabis 30-120 part Semen Sesami Nigrum 20-100 part
Matrii Sulfas Exsiccatus 20-100 part Radix Paeoniae Alba 20-100 part Flos Sophorae 30-120 part
Folium Mori 20-100 part Caulis Akebiae 20-100 part Herba Schizonepetae 50-150 part
Rhizoma Alismatis 20-100 part
2, a kind of drug regimen for the treatment of constipation as claimed in claim 1 is characterized in that the weight proportion of each component is:
60 parts of 80 portions of Semen Sesami Nigrums of 100 parts of Fructus Cannabiss of Folium Sennae
80 parts in 60 parts of Flos Sophoraes of 60 portions of Radix Paeoniae Albas of Matrii Sulfas Exsiccatus
100 parts of 60 parts of Herba Schizonepetaes of 60 portions of Caulis Akebiaes of Folium Mori
60 parts of Rhizoma Alismatis
3, as claim 1 and 2 described a kind of drug regimens for the treatment of constipation, it is characterized in that the preparation technology of this drug regimen is:
(1) get the Radix Paeoniae Alba and be ground into fine powder, standby;
(2) get nine flavors such as all the other Folium Sennae, Fructus Cannabis, be mixed in proportion, decoct with water three times, the decocting that adds for the first time 8~12 times of medical material amounts boiled 2 hours, and the decocting that adds 6~10 times of medical material amounts for the second time boiled 1 hour, and the decocting that adds 6~8 times of medical material amounts for the third time boiled 1 hour, merge decocting liquid, leave standstill, filter, filtrate is concentrated into the thick paste that relative density is 1.35~1.39 (65~85 ℃), after the cold drying, be ground into fine powder, add Radix Paeoniae Alba fine powder then, mixing, standby;
(3) molding: it is an amount of 1. to add lactose, mixing, and with 85~95% alcohol granulations, drying is made granule, promptly gets granule.2. add an amount of lactose, make granule, incapsulate, promptly get capsule with 90~100% ethanol; 3. every 100g powder adds refined honey 40~50g and an amount of water, general ball, and drying is made water-honeyed pill; Or every 100g powder adds refined honey 110~120g and makes big honeyed pills, in dry below 60 ℃, promptly gets pill; 4. add 1~3% magnesium stearate, make granule, drying, compacting promptly gets tablet in flakes.
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CN200810101480A CN101524447A (en) | 2008-03-07 | 2008-03-07 | Pharmaceutical composition for treating constipation and preparation process thereof |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102091194A (en) * | 2011-03-14 | 2011-06-15 | 山东省千佛山医院 | Traditional Chinese medicinal preparation for treating astriction |
US20140271940A1 (en) * | 2013-03-14 | 2014-09-18 | Sc Laboratories, Inc. | Bioactive concentrates and uses thereof |
CN104383155A (en) * | 2014-11-29 | 2015-03-04 | 山东省立医院 | Chinese medicinal composition for treating constipation |
-
2008
- 2008-03-07 CN CN200810101480A patent/CN101524447A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102091194A (en) * | 2011-03-14 | 2011-06-15 | 山东省千佛山医院 | Traditional Chinese medicinal preparation for treating astriction |
US20140271940A1 (en) * | 2013-03-14 | 2014-09-18 | Sc Laboratories, Inc. | Bioactive concentrates and uses thereof |
US10792318B2 (en) * | 2013-03-14 | 2020-10-06 | Sc Laboratories, Inc. | Bioactive concentrates and uses thereof |
US11752184B2 (en) | 2013-03-14 | 2023-09-12 | Purple Mundo, Inc. | Bioactive concentrates and uses thereof |
CN104383155A (en) * | 2014-11-29 | 2015-03-04 | 山东省立医院 | Chinese medicinal composition for treating constipation |
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Open date: 20090909 |