CN102370687B - A kind of compound Chinese medicinal preparation for treating colitis and preparation method thereof - Google Patents
A kind of compound Chinese medicinal preparation for treating colitis and preparation method thereof Download PDFInfo
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- CN102370687B CN102370687B CN201110364278.3A CN201110364278A CN102370687B CN 102370687 B CN102370687 B CN 102370687B CN 201110364278 A CN201110364278 A CN 201110364278A CN 102370687 B CN102370687 B CN 102370687B
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Abstract
The present invention relates to a kind of Chinese traditional compound medicine for treating colitis, includes the Chinese medicine material that following weight matches:Radix Codonopsis 8 12, the Radix Astragali 13 17, the bighead atractylodes rhizome 8 12, Poria cocos 13 17, radix glycyrrhizae 57, Radix Angelicae Sinensis 8 12, dried orange peel 57, the banksia rose 57, the coptis 8 12;Its preparation method is to clean above-mentioned 9 taste medicinal material, mix in proportion, the ethanol that 46 times of the water or volume ratio of dosing material gross weight are 70% decocts 3 times, 40 minutes every time, merges 3 decoction liquors, filtering, and concentrate, the liquid extract that proportion at 60 DEG C is 1.09 is obtained, using conventional fabrication process, Chinese medicine preparation of the present invention can be made into formulation described in any pharmacy, such as tablet, capsule, granule, oral liquid, pill, syrup.Chinese traditional compound medicine produced by the present invention is evident in efficacy, has no adverse reaction, and is adapted to the large-scale application in colitis treatment.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation for treating colitis and preparation method thereof, belongs to field of traditional Chinese.
Background technology
Colitis is also known as nonspecific ulcerative colitis, and how slow onset is, and state of an illness weight differs, and diarrhoea is main disease
Shape, discharge pus and blood stool, mucous bloody stool or bloody stool etc..
Traditional Chinese medicine thinks that this disease is more evil by weakness of the spleen and the stomach or infection poison, the cause dysfunction of the spleen in transport, liver dysfunction, and deficiency of spleen and stomach is wet
Accumulate in hot turbid pathogenic factor, caused by injuring intestines network.Or because native endowment deficiency, transporting and transforming function of the spleen and stomach mistake department, indigestion, distinguishing of small intestine it is turbid and
Large intestine conduction function is not normal, then water-damp not being transformed, close it is dirty and under, therefore see increased borborygmus and diarrhea;Mechanism of qi is hindered, and sees chest gastral cavity ruffian.
Antibiosis extract for treating colitis less effective at present, also larger side effect.
The content of the invention
It is an object of the invention to provide a kind of Chinese traditional compound medicine for treating colitis and preparation method thereof.
The present invention provides a kind of Radix Codonopsis, the Radix Astragali, the bighead atractylodes rhizome, Poria cocos, radix glycyrrhizae, Radix Angelicae Sinensis, dried orange peel, the banksia rose, the Chinese medicine of coptis compatibility
Compound preparation is used to treat colitis, evident in efficacy, has no adverse reaction.
Technical solution of the present invention is as follows:
A kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 8-12, the Radix Astragali
13-17, bighead atractylodes rhizome 8-12, Poria cocos 13-17, radix glycyrrhizae 5-7, Radix Angelicae Sinensis 8-12, dried orange peel 5-7, banksia rose 5-7, coptis 8-12.
Wherein preparation method is to clean above-mentioned 9 taste medicinal material, is mixed in proportion, 4-6 times of water of dosing material gross weight or
The ethanol that volume ratio is 70% decocts 3 times, 40 minutes every time, merges 3 decoction liquors, filtering, and concentrates, and obtains proportion at 60 DEG C
For 1.09 liquid extract, using conventional fabrication process, Chinese medicine preparation of the present invention can be made into agent described in any pharmacy
Type, such as tablet, capsule, granule, oral liquid, pill, syrup.
The Radix Astragali, Radix Codonopsis, the bighead atractylodes rhizome replenish qi to invigorate the spleen qi-restoratives in inventive formulation;Poria cocos inducing diuresis with bland drug;All medicines share, temper benefit
Strong, internal organs is so incensed that logical, all disease self-healing.Therefore Chinese traditional compound medicine produced by the present invention is evident in efficacy, has no adverse reaction.
Specific embodiment
Embodiment 1:
A kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 8, the Radix Astragali 13,
The bighead atractylodes rhizome 8, Poria cocos 13, radix glycyrrhizae 5, Radix Angelicae Sinensis 8, dried orange peel 5, the banksia rose 5, the coptis 8.
Wherein preparation method is to clean above-mentioned 9 taste medicinal material, is mixed in proportion, and 4 times of decocting of dosing material gross weight boils 3
It is secondary, 40 minutes every time, merge 3 decoction liquors, filtering, and concentrate, obtain the liquid extract that proportion at 60 DEG C is 1.09.
Embodiment 2:
A kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 10, the Radix Astragali
15th, the bighead atractylodes rhizome 10, Poria cocos 15, radix glycyrrhizae 6, Radix Angelicae Sinensis 10, dried orange peel 6, the banksia rose 6, the coptis 10.
Remaining is the same as embodiment 1.
Embodiment 3:
A kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 12, the Radix Astragali
17th, the bighead atractylodes rhizome 12, Poria cocos 17, radix glycyrrhizae 7, Radix Angelicae Sinensis 12, dried orange peel 7, the banksia rose 7, the coptis 12.
Wherein preparation method is to clean above-mentioned 9 taste medicinal material, is mixed in proportion, and 4 times of volume ratios of dosing material gross weight are
70% ethanol decocts 3 times, 40 minutes every time, merges 3 decoction liquors, filtering, and concentrates, and it is 1.09 to obtain proportion at 60 DEG C
Liquid extract.
Embodiment 4:
A kind of Chinese traditional compound medicine for treating colitis, wherein preparation method are to clean formula Chinese medicine, are mixed in proportion
Closing, the ethanol 5 that 5 times of volume ratios of dosing material gross weight are 70% decocts 3 times, 40 minutes every time, merges 3 decoction liquors, filters,
And concentrate, obtain the liquid extract that proportion at 60 DEG C is 1.09.
Remaining is the same as embodiment 1.
Embodiment 5:
A kind of Chinese traditional compound medicine for treating colitis, wherein preparation method are to clean formula Chinese medicine, are mixed in proportion
Close, 5 times of water 5 of dosing material gross weight decocts 3 times, 40 minutes every time, merges 3 decoction liquors, filtering, and concentrates, and obtains 60
DEG C when proportion be 1.09 liquid extract.
Remaining is the same as embodiment 2.
Embodiment 6:
A kind of Chinese traditional compound medicine for treating colitis, wherein preparation method are to clean formula Chinese medicine, are mixed in proportion
Close, 5 times of decocting of dosing material gross weight is boiled 3 times, 40 minutes every time, merges 3 decoction liquors, filtering, and is concentrated, and obtains 60 DEG C
When proportion be 1.09 liquid extract.
Remaining is the same as embodiment 3.
Embodiment 7:
A kind of Chinese traditional compound medicine for treating colitis, wherein preparation method are to clean formula Chinese medicine, are mixed in proportion
Closing, the ethanol that 6 times of volume ratios of dosing material gross weight are 70% decocts 3 times, 40 minutes every time, merges 3 decoction liquors, filters, and
Concentration, obtain the liquid extract that proportion at 60 DEG C is 1.09.
Remaining is the same as embodiment 2.
Embodiment 8:
A kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 15, the Radix Astragali
18th, the bighead atractylodes rhizome 15, Poria cocos 18, radix glycyrrhizae 5, Radix Angelicae Sinensis 3, dried orange peel 2, the banksia rose 2, the coptis 3.
Wherein preparation method is to clean formula Chinese medicine, is mixed in proportion, 6 times of decocting of dosing material gross weight boils 3
It is secondary, 40 minutes every time, merge 3 decoction liquors, filtering, and concentrate, obtain the liquid extract that proportion at 60 DEG C is 1.09.
Embodiment 9:
A kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 5, the Radix Astragali 10,
The bighead atractylodes rhizome 6, Poria cocos 10, radix glycyrrhizae 10, Radix Angelicae Sinensis 15, dried orange peel 10, the banksia rose 8, the coptis 6.
Wherein preparation method is to clean formula Chinese medicine, is mixed in proportion, 6 times of volume ratios of dosing material gross weight are
70% ethanol decocts 3 times, 40 minutes every time, merges 3 decoction liquors, filtering, and concentrates, and it is 1.09 to obtain proportion at 60 DEG C
Liquid extract.
Embodiment 10:
A kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 7, the Radix Astragali 18,
The bighead atractylodes rhizome 7, Poria cocos 17, radix glycyrrhizae 4, Radix Angelicae Sinensis 12, dried orange peel 4, the banksia rose 8, the coptis 7.
Wherein preparation method is to clean above-mentioned 9 taste medicinal material, is mixed in proportion, and 3 times of decocting of dosing material gross weight boils 3
It is secondary, 40 minutes every time, merge 3 decoction liquors, filtering, and concentrate, obtain the liquid extract that proportion at 60 DEG C is 1.09.
Embodiment 11:
The Chinese medicine preparation of colitis is treated according to disclosed in the patent of Application No. 99116308.7, including following weight is matched somebody with somebody
The Chinese medicine material of ratio:Radix Angelicae Sinensis 60, the root of herbaceous peony 200, the windproof 100, coptis 50, melia toosendan 100, profound Hu 100, Fructus Aurantii 100, dried orange peel 100, wood
Perfume 100, radix glycyrrhizae 60, radix bupleuri 100, the bighead atractylodes rhizome 200, the Radix Astragali 300, Radix Codonopsis 150, Poria cocos 120, jujube 40, the root of Dahurain angelica 100, rhizoma atractylodis 100,
The tuber of pinellia 80, pappy shell 100.
Wherein preparation method is to fry Radix Angelicae Sinensis, the stir-fry of root of herbaceous peony wine, the bighead atractylodes rhizome, the banksia rose, the coptis, rhizoma atractylodis, melia toosendan, profound Hu, radix bupleuri, small-mouthed jar
It is used as medicine after grain shell is vinegar-fried, is used after the Radix Astragali, liquorice root honey system, other medicinal material lifes is used, and aqua is made.An oral 200ml, three times per day
Embodiment 12:
A kind of Chinese medicine for treating colitis according to disclosed in the patent of Application No. 00132727.5, including following weight are matched somebody with somebody
The Chinese medicine material of ratio:The Radix Astragali 120, the bighead atractylodes rhizome 100, psoralea corylifolia 70, Radix Sangusorbae 100, Wu's cornel 50, jujube charcoal 80, pig nail 80, Radix Codonopsis
100th, the banksia rose 90, Poria cocos 100, radix glycyrrhizae 60.
Wherein preparation method is that said medicine is weighed into each component by ratio requirement is standby;By Radix Sangusorbae grinds;Big
Jujube charcoal is made in jujube;It is not burnt that yellow is made in the race of pig nail sandy soil;Remaining medicine is put into extractor plus 10 times of boilings boil 3
It is secondary, mix, remove slag, concentrating, low temperature drying is into dry cream;Superfine powder is mixed and made into Radix Sangusorbae powder, jujube charcoal, yellow be not burnt, then
Granulation is made;Packaging, every weight 0.2-0.3g, every bottle 100 on chip.Oral 2 tablets once, 3 times a day.
Embodiment 13:Using conventional fabrication process, Chinese medicine preparation of the present invention can be made into any pharmacy described
Formulation, such as tablet, capsule, granule, oral liquid, pill, syrup.
Remaining is the same as embodiment 1-10.
Embodiment 14:The liquid extract being well mixed as made from embodiment 1-10 is concentrated, according to the operation of conventional tablet
Method, pharmaceutic adjuvant is added, each component is well mixed, wet granulation, sieved, preparation method tabletting using conventional tablet is made piece
The content of agent, wherein each component is as follows:
Ingredients Weight(Part)
Mix liquid extract 50
Starch 22
Microcrystalline cellulose 15
Talcum powder 10
Polyethylene glycol 6
Remaining is the same as embodiment 1-10.
Embodiment 15:The liquid extract being well mixed as made from embodiment 1-10 is concentrated, according to the behaviour of conventional capsule
Make method, add pharmaceutic adjuvant, each component is well mixed, pelletize, preparation method filling using conventional capsule is made capsule,
The content of wherein each component is as follows:
Ingredients Weight(Part)
Mix liquid extract 100
Pregelatinized starch 25
Lactis Anhydrous 20
Microcrystalline cellulose 15
Calcium monohydrogen phosphate 8
Remaining is the same as embodiment 1-10.
Embodiment 16:The liquid extract being well mixed as made from embodiment 1-10 is concentrated, according to the behaviour of traditional oral liquid
Make method, ethanol precipitation 1-2 times, filter, concentration, aqueous precipitation, filtering, add pharmaceutic adjuvant, filtering, packing sterilizing, use
Traditional oral liquid prepares method and prepares oral liquid, and the content of wherein each component is as follows:
Ingredients Weight(Part)
Mix liquid extract 100
Ethanol 150
Sucrose 85
Sodium carboxymethylcellulose 15
Peppermint oil 5
Sorbic acid 2
Remaining is the same as embodiment 1-10.
Effectiveness study is tested:
Patient data:
Totally 377 patients, wherein male 191, women 186;It is minimum 20 years old, it is maximum 68 years old, average 40.7
Year;The course of disease is most short 2 years, most long 22 years, average 10.3.All subjects for meeting each diagnostic criteria are according to table of random number
Method is divided into 13 groups, every group 29, wherein 1 group as a control group, 12 groups are used as treatment group, the sexes of 13 groups of data, the age,
It is not statistically significant that the course of disease is statistically analyzed difference(P>0.05), there is comparativity.
Treatment method:
Control group oral sulfasalazine, just amount is a 1-1.5g, often 6-8 hours 1 time.Maintenance dose is once
0.5g, every 6 hours 1 time;By embodiment 1-10 respectively made from 9 times by volume of water of Chinese traditional compound medicine, respectively to 10 groups
Treatment group takes, once oral 100ml, and 3 times a day, remaining Liang Zu treatment groups distinguish oral embodiment 11 and embodiment 12 and made
The herbal mixture obtained;Control group and treatment group all continuous drug administrations 3 months.
Criterion of therapeutical effect
The effect of being formulated with reference to national chronic noninfective intestines problem academic discussion standard rating.1. clinical cure:
Clinical symptom disappearance, excrement symptom and microscopy are normal, 2 times/d of bowel frequency <, and colonoscopy finding non-cancer lesion disappears, blood vessel
Clean mark, color and luster is normal, and for intestinal mucosa without inflammatory cell infiltration, body of gland is without exception, and follow-up 1 year is without recurrence.2. take a turn for the better:Face
Bed symptom mitigation, colonoscopy show that non-cancer lesion takes a turn for the better.It is 3. invalid:Clinical symptoms and colonoscopy without significant change or
Aggravate.
The each group treatment results of table 1 are compared with curative effect
There are 2 drug rash, 1 alpastic anemia, 1 nausea and vomiting over the course for the treatment of in control group;Treatment group exists
Do not occur any adverse reaction in therapeutic process.
The effect of from effectiveness study experiment as can be seen that of the invention, is substantially better than the oral western medicine of existing treatment colitis,
And it is better than in the prior art made from similar formula the effect of Chinese medicine, wherein optimal with the therapeutic effect of embodiment 5;Cause
This, Chinese traditional compound medicine produced by the present invention is evident in efficacy, has no adverse reaction, and is adapted to the large-scale application in colitis treatment.
Claims (5)
1. a kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 8-12, the Radix Astragali
13-17, bighead atractylodes rhizome 8-12.
2. a kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 8-12, the Radix Astragali
13-17, bighead atractylodes rhizome 8-12, Poria cocos 13-17, radix glycyrrhizae 5-7, Radix Angelicae Sinensis 8-12, dried orange peel 5-7, banksia rose 5-7, coptis 8-12.
3. a kind of Chinese traditional compound medicine for treating colitis, include the Chinese medicine material of following weight proportioning:Radix Codonopsis 10, the Radix Astragali 15,
The bighead atractylodes rhizome 10, Poria cocos 15, radix glycyrrhizae 6, Radix Angelicae Sinensis 10, dried orange peel 6, the banksia rose 6, the coptis 10.
4. a kind of preparation method for the Chinese traditional compound medicine for treating colitis as described in Claims 2 or 3, it is characterized in that:By 9 tastes
Medicinal material is cleaned, and is mixed in proportion, and the ethanol that 4-6 times of the water or volume ratio of dosing material gross weight are 70% decocts 3 times, and every time 40
Minute, merge 3 decoction liquors, filtering, and concentrate, obtain the liquid extract that proportion at 60 DEG C is 1.09, using conventional fabrication process,
Chinese medicine preparation of the present invention can be made into formulation described in any pharmacy, such as tablet, capsule, granule, oral liquid, ball
Agent, syrup.
5. a kind of preparation method for the Chinese traditional compound medicine for treating colitis as claimed in claim 4, it is characterized in that:By 9 tastes
Medicinal material is cleaned, and is mixed in proportion, and 5 times of decocting of dosing material gross weight is boiled 3 times, 40 minutes every time, merges 3 decoction liquors, mistake
Filter, and concentrate, the liquid extract that proportion at 60 DEG C is 1.09 is obtained, using conventional fabrication process, Chinese medicine preparation of the present invention can be made into
Described formulation in any pharmacy, such as tablet, capsule, granule, oral liquid, pill, syrup.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR102150548B1 (en) | 2017-04-25 | 2020-09-01 | 대구한의대학교산학협력단 | A composition comprising mixture of the herb extract and sulfasalazine for preventing or treating colitis |
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CN102641486A (en) * | 2012-04-02 | 2012-08-22 | 王永刚 | Preparation method of traditional Chinese medicine for treating blood-deficiency-type colonitis |
CN103070955A (en) * | 2013-01-12 | 2013-05-01 | 张石柱 | Traditional Chinese medicine powder for treating colonitis and preparation method of same |
CN103301257B (en) * | 2013-05-16 | 2015-05-20 | 聂明明 | Traditional Chinese medicine plaster for treating colitis and preparation method thereof |
CN104208230A (en) * | 2014-09-26 | 2014-12-17 | 禤燕华 | Chinese medicinal composition for treating chronic colitis |
CN104887967A (en) * | 2015-06-10 | 2015-09-09 | 吴光付 | Traditional Chinese medicine composition for treating ulcerative colitis and preparation method thereof |
CN105343687A (en) * | 2015-11-13 | 2016-02-24 | 张雯 | Traditional Chinese medicine for treating rectitis and colitis and its preparation method |
CN107019774B (en) * | 2017-05-05 | 2020-05-19 | 欧显华 | Traditional Chinese medicine composition for treating intestinal diseases of livestock and poultry and application thereof |
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KR102150548B1 (en) | 2017-04-25 | 2020-09-01 | 대구한의대학교산학협력단 | A composition comprising mixture of the herb extract and sulfasalazine for preventing or treating colitis |
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