CN103417674B - Medicine composition for treating constipation and preparation method and specific uses thereof - Google Patents
Medicine composition for treating constipation and preparation method and specific uses thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of Chinese medicine, and particularly provides a medicine composition for treating constipation. The raw material medicines are composed of cistanche, bighead atractylodes rhizome and semen pruni, and the weight composition range is as follows: 5 to 50 parts of cistanche, 10 to 40 parts of bighead atractylodes rhizome and 10 to 40 parts of semen pruni. The invention further provides a preparation method and specific uses of the medicine composition. Proved by a pharmacological experiment, the medicine composition can obviously shorten first defecating time and increase defecating quantity, and testified by the mice carbon powder boosting experimental research, the medicine composition has the function of promoting small intestine wriggle.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of constipation, especially relate to a kind of Chinese medicine composition for the treatment of constipation and its production and use, belong to technical field of Chinese medicines.
Background technology
Constipation refers to that constipation is obstructed, infrequent defecation time lengthening, or has awareness of defecation and discharge difficult a kind of disease.Doctor trained in Western medicine is called habitual constipation, or the constipation of temporary Intestinal motility imbalance, and the constipation concurrent because of Other diseases, all belongs to assertive evidence category.Constipation can be divided into organic and functional two classes the cause of disease.Organic diseases is because mainly comprising: intestinal tube organic disease: the stenosis of bowel that tumor, inflammation or other reasons cause or block; Rectum, anus pathological changes: bulging before internal rectal prolapse, hemorrhoid, rectum, puborectalis is plump, shame is directly separated, sick etc. at the bottom of basin; Endocrine or metabolic disease: glycosuria hypothyroidism, disease of parathyroid glands etc.; Nervous system disease: central brain disorder, apoplexy, multiple sclerosis, spinal cord injury and peripheral neuropathy etc.; Intestinal tube smooth muscle or neurogenic pathological changes; Colon neuromuscular pathological changes: intestinal pseudo obstruction, congenital megacolon, megarectum etc.
For the treatment of constipation, current doctor trained in Western medicine usually selects bulk-forming cathartic and motor activation regulator two class.Bulk-forming laxative mainly comprises soluble cellulose (pectin, Herba Plantaginis, Herba bromi japonici bran etc.) and insoluble fibers (Plant fiber, lignin etc.).Motor activation regulator mainly comprises mosapride, itopride and general card Billy etc.Bulk-forming laxative onset is slow and side effect is little, safety, therefore has good therapeutic effect to pregnant constipation or mild constipation, but is not suitable as the rapid relieving constipation treatment of temporary constipation.Although motor activation regulator can promote gastrointestinal peristalsis, easily drug-resistant effect should not be produced by long-term taking.
Chinese medicine thinks that the generation of constipation and spleen, stomach, kidney, pulmonary function are lacked of proper care closely related.Chinese patent technology at present for constipation mainly adopts purgatives medicine or heat clearing and fire purging medicine combination and compatibility to carry out symptomatic treatment.Chinese patent ZL200910071180.1 discloses a kind of Chinese patent medicine for the treatment of constipation and preparation method thereof, and this Chinese patent medicine is by Rhizoma Coptidis 90-95 part, Halloysitum Rubrum 4-8 part, Radix Et Rhizoma Rhei 20-50, Semen Sesami Nigrum 1-2 part.Chinese patent ZL201010507733.6 discloses a kind of medicament for the treatment of constipation, and this medicament is made up of Radix Et Rhizoma Rhei 8 grams, Radix Aconiti Lateralis Preparata 10 grams, Herba Asari 6 grams, Rhizoma Zingiberis 10 grams, Radix Ginseng 6 grams, 6 grams, Radix Glycyrrhizae, Fructus Cannabis 10 grams, 10 grams, Semen Persicae.Chinese patent ZL201010279036.X discloses a kind of herbal composite for the treatment of simple constipation, this pharmaceutical composition by Aloe 10-20 part, Fructus Cannabis 10-20 part, Radix Paeoniae Alba 20-30 part, process Fructus Aurantii Immaturus 20-30 part, Radix Et Rhizoma Rhei 5-15 part, process Cortex Magnoliae Officinalis 10-20 part, Semen Armeniacae Amarum 10-20 part, Cinnabaris 10-20 part forms.Chinese patent ZL200810056930.3 discloses a kind of compound Chinese patent medicine for the treatment of constipation, and this Chinese patent medicine is made up of Herba Cistanches 15 ~ 65 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 45 parts, Rhizoma Alismatis 10 ~ 45 parts, Semen Pruni 10 ~ 45 parts, Semen Armeniacae Amarum 15 ~ 65 parts, Semen Platycladi 15 ~ 65 parts, Semen Juglandis 5 ~ 35 parts, 5 ~ 35 parts, Semen Persicae, 10 ~ 45 parts, the Radix Euphorbiae Pekinensis, Radix Ophiopogonis 15 ~ 65 parts, 15 ~ 65 parts, Fructus Hordei Germinatus, Herba Cynomorii 10 ~ 45 parts, Fructus Crataegi 10 ~ 45 parts, Flos Lonicerae 20 ~ 60 parts, Radix Platycodonis 20 ~ 60 parts, Fructus Aurantii Immaturus 10 ~ 45 parts and 10 ~ 45 parts, Fructus Jujubae.Although above-mentioned patented composition has therapeutical effect in various degree to constipation, because the taste number of medicine is more, a large amount of raw material of consumption is needed to be unfavorable for the saving of resource when industrialized great production.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, provide a kind of flavour of a drug few, composition is simple, and the pharmaceutical composition of identical curative effect can be reached, this pharmaceutical composition is made up of following raw material and weight ratio: Herba Cistanches 5-50 weight portion, Rhizoma Atractylodis Macrocephalae 10-40 weight portion, Semen Pruni 10-40 weight portion; Preferably, Herba Cistanches 15-45 weight portion, Rhizoma Atractylodis Macrocephalae 15-35 weight portion, Semen Pruni 15-35 weight portion; Preferably, Herba Cistanches 20-40 weight portion, Rhizoma Atractylodis Macrocephalae 20-30 weight portion, Semen Pruni 20-30 weight portion; Preferably, Herba Cistanches 30 weight portion, the Rhizoma Atractylodis Macrocephalae 20 weight portion, Semen Pruni 10 weight portion.
The pharmaceutical composition for the treatment of constipation of the present invention is except the form fed intake with the Rhizoma Atractylodis Macrocephalae, Herba Cistanches, Semen Pruni crude drug, the form fed intake with the Rhizoma Atractylodis Macrocephalae, Herba Cistanches, Semen Pruni (effective site) can also be adopted, therefore the present invention further discloses a kind of extract pharmaceutical composition for the treatment of constipation, the raw material of this pharmaceutical composition consists of: Herba Cistanches extract 5-50 weight portion, Rhizoma Atractylodis Macrocephalae extract 10-40 weight portion, Semen Pruni extract 10-40 weight portion.Preferably, Herba Cistanches extract 10-40 weight portion, Rhizoma Atractylodis Macrocephalae extract 15-35 weight portion, Semen Pruni extract 15-35 weight portion.Preferably, Herba Cistanches extract 30 weight portion, Rhizoma Atractylodis Macrocephalae extract 20 weight portion, Semen Pruni extract 20 weight portion.
The present invention also aims to provide one to prepare pharmaceutical composition preparation method of the present invention, it comprises the following steps:
S1: take raw material by component and weight ratio;
S2: after raw material mix homogeneously, adds pharmaceutically acceptable adjuvant and is prepared into pharmaceutically conventional pharmaceutical preparation.
Pharmaceutical composition of the present invention can be prepared into dosage form described on any one pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition can by oral, to suck or the mode such as intestinal external administration is applied to patient.Described pharmaceutically conventional types of drug preparations comprises: the tablet used during oral administration, effervescent tablet, capsule, pill, powder, granule, syrup, oral liquid etc.; The freeze-dried powder used when intestinal external administration and injection etc.
This pharmaceutical composition is used for the purposes in preparation treatment constipation medicine.
For enabling above-mentioned dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: insect wax etc.
Herba Cistanches extract of the present invention: weighting raw materials Herba Cistanches, with 70%-95% alcoholic solution reflux, extract, 3 times, each 1-2h, filter, merging filtrate, concentrating under reduced pressure obtains thick extractum, after spray-dried extract powder i.e. obtained Herba Cistanches extract.
Rhizoma Atractylodis Macrocephalae extract: the weighting raw materials Rhizoma Atractylodis Macrocephalae, with 70%-95% alcoholic solution reflux, extract, 3 times, each 1-2h, filter, merging filtrate, concentrating under reduced pressure obtains thick extractum, after spray-dried extract powder i.e. obtained Rhizoma Atractylodis Macrocephalae extract.
Semen Pruni extract: weighting raw materials Semen Pruni, with 70%-95% alcoholic solution reflux, extract, 3 times, each 1-2h, filter, merging filtrate, concentrating under reduced pressure obtains thick extractum, after spray-dried extract powder i.e. obtained Semen Pruni extract.
Its method for preparing extractive can also select any one method conventional such as soak extraction, supersound extraction or seepage pressure effects to extract; Further, crude drug also can purified, refinement treatment after extracting, as crossed macroporous resin column.
The Rhizoma Atractylodis Macrocephalae of the present invention, Herba Cistanches, Semen Pruni are 2010 editions " Chinese Pharmacopoeias " first Chinese medicine of recording or its processed product.Wherein, the Rhizoma Atractylodis Macrocephalae has air making-up and spleen enlivening, dampness diuretic, strengthening superficial resistance to stop perspiration, antiabortive effect, for the card such as anorexia and loose stool, distension and fullness in the abdomen, the soft Mental fatigue of limb, frequent fetal movement that deficiency of the spleen causing weakness of QI, transporting are unable; Herba Cistanches has kidney-replenishing, benefiting essence-blood, effect of loosening bowel to relieve constipation, for insufficiency of kidney-YANG, and the card such as unable and dryness of the intestine constipation of the sexual impotence of blood and essence asthenia, infertile, soreness of the waist and knees, muscles and bones; Semen Pruni has loosening bowel to relieve constipation, the merit of inducing diuresis to remove edema, for cards such as dryness of the intestine constipation, edema abdominal distention, beriberi edema.
The beneficial effect that pharmaceutical composition of the present invention is verified through pharmacodynamics is:
Pharmaceutical composition of the present invention becomes in medicine composition to remove Rhizoma Alismatis, Semen Armeniacae Amarum, Semen Platycladi, Semen Juglandis, Semen Persicae, the Radix Euphorbiae Pekinensis, Radix Ophiopogonis, Fructus Hordei Germinatus, Herba Cynomorii, Fructus Crataegi, Flos Lonicerae, Radix Platycodonis, Fructus Aurantii Immaturus and Fructus Jujubae in the prior art, retain Herba Cistanches, the Rhizoma Atractylodis Macrocephalae and Semen Pruni three kinds of medicines, prove by dose compatibility of the present invention through overtesting, the therapeutic effect of its therapeutic effect and former Chinese patent medicine is close, after extracting the live part of Herba Cistanches, the Rhizoma Atractylodis Macrocephalae and Semen Pruni, carry out compatibility again by dosage of the present invention, its therapeutic effect is then better than the therapeutic effect of former Chinese patent medicine.This pharmaceutical composition compared with prior art medication amount reduces, and composition is simpler, and reaches identical therapeutic effect, has good therapeutical effect to constipation patient.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited to the following stated.
Embodiment 1
Take raw meat Herba Cistanches 5kg, Rhizoma Atractylodis Macrocephalae 10kg, Semen Pruni 10kg, conveniently process adds adjuvant and is prepared into tablet.
Embodiment 2
Take raw meat Herba Cistanches 10kg, Rhizoma Atractylodis Macrocephalae 15kg, Semen Pruni 15kg, conveniently process adds adjuvant and is prepared into tablet.
Embodiment 3
Take raw meat Herba Cistanches 15kg, Rhizoma Atractylodis Macrocephalae 20kg, Semen Pruni 20kg, conveniently process adds adjuvant and is prepared into tablet.
Embodiment 4
Take raw meat Herba Cistanches 30kg, Rhizoma Atractylodis Macrocephalae 20kg, Semen Pruni 10kg, conveniently process adds adjuvant and is prepared into tablet.
Embodiment 5
Take raw meat Herba Cistanches 30kg, Rhizoma Atractylodis Macrocephalae 20kg, Semen Pruni 20kg, conveniently process adds adjuvant and is prepared into granule.
Embodiment 6
Take raw meat Herba Cistanches 40kg, Rhizoma Atractylodis Macrocephalae 30kg, Semen Pruni 30kg, conveniently process adds adjuvant and is prepared into capsule.
Embodiment 7
Take raw meat Herba Cistanches 45kg, Rhizoma Atractylodis Macrocephalae 35kg, Semen Pruni 35kg, conveniently process adds adjuvant and is prepared into capsule.
Embodiment 8
Take raw meat Herba Cistanches 50kg, Rhizoma Atractylodis Macrocephalae 40kg, Semen Pruni 40kg, conveniently process adds adjuvant and is prepared into capsule.
Embodiment 9
Take raw material Herba Cistanches extract 5kg, Rhizoma Atractylodis Macrocephalae extract 10kg, Semen Pruni extract 10kg, conveniently process adds adjuvant and is prepared into tablet.
Embodiment 10
Take raw material Herba Cistanches extract 15kg, Rhizoma Atractylodis Macrocephalae extract 20kg, Semen Pruni extract 20kg, conveniently process adds adjuvant and is prepared into tablet.
Embodiment 11
Take raw material Herba Cistanches extract 30kg, Rhizoma Atractylodis Macrocephalae extract 20kg, Semen Pruni extract 20kg, conveniently process adds adjuvant and is prepared into granule.
Embodiment 12
Take raw material Herba Cistanches extract 35kg, Rhizoma Atractylodis Macrocephalae extract 25kg, Semen Pruni extract 25kg, conveniently process adds adjuvant and is prepared into capsule.
Embodiment 13
Take raw material Herba Cistanches extract 40kg, Rhizoma Atractylodis Macrocephalae extract 30kg, Semen Pruni extract 30kg, conveniently process adds adjuvant and is prepared into capsule.
Embodiment 14
Take raw material Herba Cistanches extract 50kg, Rhizoma Atractylodis Macrocephalae extract 40kg, Semen Pruni extract 40kg, conveniently process adds adjuvant and is prepared into capsule.
Beneficial effect of the present invention is proved below by concrete pharmacy test:
One, medicine of the present invention is on the impact of normal rat defecation
1 experiment material
1.1 laboratory animal
Femalely do not educate SPF level SD rat 110, body weight 200 ± 20g, provide by institute of lab animals of Sichuan Academy of Medical Sciences, animal credit number: SCXK (river) 2010-12, at room temperature 22-24 DEG C, raise under light and shade cycle 12h/12h condition, freely drink water and ingest.
1.2 Experimental agents
Positive control Chinese patent medicine group: this positive controls adopts the Chinese patent medicine formula in background technology, this formula by Herba Cistanches 45g, Rhizoma Atractylodis Macrocephalae 35g, Semen Pruni 35g, Rhizoma Alismatis 35g, Semen Armeniacae Amarum 45g, Semen Platycladi 45g, Semen Juglandis 25g, Semen Persicae 25g, Radix Euphorbiae Pekinensis 35g, Radix Ophiopogonis 45g, Fructus Hordei Germinatus 45g, Herba Cynomorii 35g, Fructus Crataegi 35g, Flos Lonicerae 40g, Radix Platycodonis 40g, Fructus Aurantii Immaturus 35g and Fructus Jujubae 35g form.Take each raw material according to above-mentioned weight ratio, soak 1.5 hours after mixing, then decoct 3 times, each 1 hour, merge decocting liquid and filter, filtrate is concentrated into the medicinal liquid of 0.5g/ml, and 4 DEG C save backup.
Pharmaceutical composition: Herba Cistanches 3kg, Rhizoma Atractylodis Macrocephalae 2kg, Semen Pruni 2kg, with 8 times amount soak by water 1 hour, decoct 2 times respectively, merge twice decocting liquid, gained medicinal liquid double gauze is filtered, is condensed into the medicinal liquid of 0.5g/ml, 4 DEG C save backup, be dosage in pharmaceutical composition (to get part medicinal liquid and add same volume normal saline, be mixed with the medicinal liquid of 0.25g/ml, be compositions low dosage; Therefrom dosage group gets part concentration of liquid medicine again, is mixed with the medicinal liquid of 1g/ml, is compositions high dose).
Extract group: take raw material Herba Cistanches extract 300g, Rhizoma Atractylodis Macrocephalae extract 200g, Semen Pruni extract 200g, the medicinal liquid that distilled water is mixed with 0.5g/ml is added after Homogeneous phase mixing, 4 DEG C save backup, be dosage group in extract (to get part medicinal liquid and add same volume normal saline, be mixed with the medicinal liquid of 0.25g/ml, be extract low dosage; Therefrom dosage group gets part concentration of liquid medicine again, is mixed with the medicinal liquid of 1g/ml, is extract high dose group).
Herba Cistanches extract group: take 200g Herba Cistanches extract, adds the medicinal liquid that distilled water is mixed with 0.5g/ml, and 4 DEG C save backup.
Rhizoma Atractylodis Macrocephalae extract group: take 200g Rhizoma Atractylodis Macrocephalae extract, adds the medicinal liquid that distilled water is mixed with 0.5g/ml, and 4 DEG C save backup.
Semen Pruni extract group: take 200g Semen Pruni extract, adds the medicinal liquid that distilled water is mixed with 0.5g/ml, and 4 DEG C save backup.
2 experimental techniques and grouping
SD rat is randomized into dosage group, extract low dose group, Herba Cistanches extract group, Rhizoma Atractylodis Macrocephalae extract group, Semen Pruni extract group in Normal group, positive control Chinese patent medicine group, compositions high dose, middle dosage, low dose group, extract high dose group, extract, often group gives gavage by 1ml/ dosage only, Normal group gavage 1ml/ normal saline only.After gavage terminates, rat is put into metabolic cage, place mat aluminium-foil paper under metabolic cage, observe the gross weight that it voids excreta in defecation time, the 3h that weighs first.Weight=the aluminium-foil paper of feces and feces total amount ﹣ aluminium-foil paper weight.
3 results
The each group of impact on normal rat defecation (see table 1).
Table 1 is on the impact of normal rat defecation
Note: compare with Normal group,
▲p<0.05;
▲ ▲p<0.01
As shown in Table 1, relative to Normal group, positive control Chinese patent medicine group, combination object height, middle dosage group, the high, medium and low dosage group of extract all can shorten defecation time first, in 3h, defecation weight all obviously increases, there is statistical significance, show that above-mentioned treatment group has the effect promoting defecation.Compositions high dose group, extract object height, middle dosage group compared with positive control Chinese patent medicine group, its therapeutical effect is more obvious.
Experimental result is pointed out, and has the trend shortening defecation time and increase feces volume first separately with Herba Cistanches extract, Rhizoma Atractylodis Macrocephalae extract, Semen Pruni extract, but not statistically significant.Under identical dosage condition, defecation time and increase feces volume first will significantly can be shortened after Herba Cistanches extract, Rhizoma Atractylodis Macrocephalae extract and Semen Pruni extract combination and compatibility, there is statistical significance, pointing out these three kinds of medicines by having the effect of Synergistic after certain proportion compatibility.
Above-mentioned experimental result shows, Rhizoma Alismatis in positive control Chinese patent medicine formula, Semen Armeniacae Amarum, Semen Platycladi, Semen Juglandis, Semen Persicae, the Radix Euphorbiae Pekinensis, Radix Ophiopogonis, Fructus Hordei Germinatus, Herba Cynomorii, Fructus Crataegi, Flos Lonicerae, Radix Platycodonis, Fructus Aurantii Immaturus and Fructus Jujubae are removed, retain Herba Cistanches of the present invention, the Rhizoma Atractylodis Macrocephalae and Semen Pruni, and carry out combination and compatibility according to dosage of the present invention, the curative effect of its treatment constipation is close with the curative effect of former compound Chinese patent medicine, after carrying out extraction recombinant compatibility to Herba Cistanches, the Rhizoma Atractylodis Macrocephalae and Semen Pruni live part, the curative effect of its treatment constipation is slightly better than existing compound Chinese patent medicine.
Two, medicine of the present invention is on the impact of normal mouse defecation
1 experiment material
1.1 laboratory animal
Kunming mice 110, male and female half and half, body weight 20 ± 2g, there is provided by institute of lab animals of Sichuan Academy of Medical Sciences, animal credit number: SCXK (river) 2010-12, at room temperature 22-24 DEG C, raise under light and shade cycle 12h/12h condition, freely drink water and ingest.
1.2 Experimental agents
Positive control Chinese patent medicine group: this positive controls adopts the Chinese patent medicine formula in background technology, this formula by Herba Cistanches 45g, Rhizoma Atractylodis Macrocephalae 35g, Semen Pruni 35g, Rhizoma Alismatis 35g, Semen Armeniacae Amarum 45g, Semen Platycladi 45g, Semen Juglandis 25g, Semen Persicae 25g, Radix Euphorbiae Pekinensis 35g, Radix Ophiopogonis 45g, Fructus Hordei Germinatus 45g, Herba Cynomorii 35g, Fructus Crataegi 35g, Flos Lonicerae 40g, Radix Platycodonis 40g, Fructus Aurantii Immaturus 35g and Fructus Jujubae 35g form.Take each raw material according to above-mentioned weight ratio, soak 1.5 hours after mixing, then decoct 3 times, each 1 hour, merge decocting liquid and filter, filtrate is concentrated into the medicinal liquid of 0.5g/ml, and 4 DEG C save backup.
Pharmaceutical composition: Herba Cistanches 3kg, Rhizoma Atractylodis Macrocephalae 2kg, Semen Pruni 2kg, with 8 times amount soak by water 1 hour, decoct 2 times respectively, merge twice decocting liquid, gained medicinal liquid double gauze is filtered, is condensed into the medicinal liquid of 0.5g/ml, 4 DEG C save backup, be dosage in pharmaceutical composition (to get part medicinal liquid and add same volume normal saline, be mixed with the medicinal liquid of 0.25g/ml, be compositions low dosage; Therefrom dosage group gets part concentration of liquid medicine again, is mixed with the medicinal liquid of 1g/ml, is compositions high dose).
Extract group: take raw material Herba Cistanches extract 300g, Rhizoma Atractylodis Macrocephalae extract 200g, Semen Pruni extract 200g, the medicinal liquid that distilled water is mixed with 0.5g/ml is added after Homogeneous phase mixing, 4 DEG C save backup, namely in extract, dosage group (is got part medicinal liquid and is added same volume normal saline, be mixed with the medicinal liquid of 0.25g/ml, be extract low dose group; Therefrom dosage group gets part concentration of liquid medicine again, is mixed with the medicinal liquid of 1g/ml, is extract high dose group).
Herba Cistanches extract group: take 300g Herba Cistanches extract, adds the medicinal liquid that distilled water is mixed with 0.5g/ml, and 4 DEG C save backup.
Rhizoma Atractylodis Macrocephalae extract group: take 200g Rhizoma Atractylodis Macrocephalae extract, adds the medicinal liquid that distilled water is mixed with 0.5g/ml, and 4 DEG C save backup.
Semen Pruni extract group: take 200g Semen Pruni extract, adds the medicinal liquid that distilled water is mixed with 0.5g/ml, and 4 DEG C save backup.
2 experimental techniques and grouping
Kunming mice is randomized into dosage group, extract low dose group, Herba Cistanches extract group, Rhizoma Atractylodis Macrocephalae extract group, Semen Pruni extract group in Normal group, positive control Chinese patent medicine group, compositions high dose, middle dosage, low dose group, extract high dose group, extract, often group gives gavage by 1ml/ dosage only, Normal group gavage 1ml/ normal saline only.Continuous gavage 5 days, every day 1 time, after within the 5th day, gavage terminates, fasting 24 hours, each administration group gavage 10% carbon powder mixed liquor on the 2nd, after 15 minutes, animal is put to death in punctual dislocation, measures small intestinal total length (pylorus is to ileocecus) and the carbon powder front end displacement at small intestinal.
3 results
Each group, on the impact of mice carbon powder advance distance, the results are shown in Table 2.
Table 2 each group of impact on mice carbon powder advance distance
Note: compare with Normal group,
▲p<0.05; Compare with model group, * P<0.05
As shown in Table 2, relative to Normal group, positive control Chinese patent medicine group, compositions high, medium and low dosage group and the high, medium and low dosage group of extract all significantly can advance carbon powder (p<0.05), show that above-mentioned each treatment group has the effect promoting small intestinal peristalsis.
Experimental result is pointed out, and has progradation trend separately with Herba Cistanches extract, Rhizoma Atractylodis Macrocephalae extract, Semen Pruni extract to mice carbon powder, but not statistically significant.Under identical dosage condition, by more remarkable to the progradation of mice carbon powder after Herba Cistanches extract, Rhizoma Atractylodis Macrocephalae extract and Semen Pruni extract combination and compatibility, there is statistical significance, pointing out these three kinds of medicines by having the effect of Synergistic after certain proportion compatibility.
Above-mentioned experimental result shows, Rhizoma Alismatis in positive control Chinese patent medicine formula, Semen Armeniacae Amarum, Semen Platycladi, Semen Juglandis, Semen Persicae, the Radix Euphorbiae Pekinensis, Radix Ophiopogonis, Fructus Hordei Germinatus, Herba Cynomorii, Fructus Crataegi, Flos Lonicerae, Radix Platycodonis, Fructus Aurantii Immaturus and Fructus Jujubae are removed, retain Herba Cistanches of the present invention, the Rhizoma Atractylodis Macrocephalae and Semen Pruni, and carry out combination and compatibility according to dosage of the present invention, the curative effect of its treatment constipation is close with the curative effect of former compound Chinese patent medicine, after carrying out extraction recombinant compatibility to Herba Cistanches, the Rhizoma Atractylodis Macrocephalae and Semen Pruni live part, the curative effect of its treatment constipation is slightly better than existing compound Chinese patent medicine.
Claims (6)
1. treat a pharmaceutical composition for constipation, it is characterized in that: the ratio of weight and number of described each raw material is: Herba Cistanches extract 5-50 weight portion, Rhizoma Atractylodis Macrocephalae extract 10-40 weight portion, Semen Pruni extract 10-40 weight portion.
2. a kind of pharmaceutical composition for the treatment of constipation according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Herba Cistanches extract 10-40 weight portion, Rhizoma Atractylodis Macrocephalae extract 15-35 weight portion, Semen Pruni extract 15-35 weight portion.
3. a kind of pharmaceutical composition for the treatment of constipation according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Herba Cistanches extract 30 weight portion, Rhizoma Atractylodis Macrocephalae extract 20 weight portion, Semen Pruni extract 20 weight portion.
4. prepare a method for the pharmaceutical composition of the treatment constipation in claims 1 to 3 described in any one claim, it is characterized in that: it comprises the following steps:
S1: take raw material by component and weight ratio;
S2: after raw material mix homogeneously, adds pharmaceutically acceptable adjuvant and is prepared into pharmaceutically conventional pharmaceutical preparation.
5. a kind of preparation method for the treatment of the pharmaceutical composition of constipation according to claim 4, is characterized in that: described pharmaceutical preparation is tablet, capsule, granule, pill, powder or oral liquid.
6. as the purposes of the pharmaceutical composition in claims 1 to 3 as described in any one claim in preparation treatment constipation medicine.
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| CN101129586A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese medicine composition for treating constipation |
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| CN101837053A (en) * | 2010-05-28 | 2010-09-22 | 中国人民解放军总医院 | Chinese medicinal composition and preparation for loosening bowel and relieving constipation and preparation method thereof |
| CN102688379A (en) * | 2012-05-31 | 2012-09-26 | 李珍华 | Chinese herbal medicine pill for treating constipation |
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2013
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| CN1088810A (en) * | 1993-01-01 | 1994-07-06 | 广州中药一厂 | The compound Chinese patent medicine of treatment constipation |
| CN101129586A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese medicine composition for treating constipation |
| CN101480466A (en) * | 2008-01-09 | 2009-07-15 | 北京北卫药业有限责任公司 | Prescription of medicament for treating constipation and preparation method |
| CN101229256A (en) * | 2008-01-14 | 2008-07-30 | 北京中科雍和医药技术有限公司 | Medicine compounds for treating customary constipation and preparing method thereof |
| CN101496876A (en) * | 2008-01-28 | 2009-08-05 | 天科仁祥技术（北京）有限责任公司 | Compound Chinese patent medicine for treating constipation |
| CN101428111A (en) * | 2008-12-24 | 2009-05-13 | 吉林修正药业新药开发有限公司 | Traditional Chinese medicine compound formulation for treating habitual constipation and preparation method thereof |
| CN101837053A (en) * | 2010-05-28 | 2010-09-22 | 中国人民解放军总医院 | Chinese medicinal composition and preparation for loosening bowel and relieving constipation and preparation method thereof |
| CN102688379A (en) * | 2012-05-31 | 2012-09-26 | 李珍华 | Chinese herbal medicine pill for treating constipation |
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