CN102430073B - Medicinal composition for treating peptic ulcer - Google Patents
Medicinal composition for treating peptic ulcer Download PDFInfo
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- CN102430073B CN102430073B CN 201110413686 CN201110413686A CN102430073B CN 102430073 B CN102430073 B CN 102430073B CN 201110413686 CN201110413686 CN 201110413686 CN 201110413686 A CN201110413686 A CN 201110413686A CN 102430073 B CN102430073 B CN 102430073B
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Abstract
The invention discloses a medicinal composition for treating peptic ulcer, which is a preparation prepared from the following Chinese herbal medicines in part by weight: 14 to 26 parts of coix seed, 14 to 26 parts of Chinese waxgourd semen, 10.5 to 19.5 parts of virgate wormwood herb, 10.5 to 19.5 parts of largehead atractylodes rhizome, 7 to 13 parts of perilla leaf, 7 to 13 parts of bitter apricot seed, 7 to 13 parts of white hyacinth bean, 7 to 13 parts of nutmeg, 7 to 13 parts of astragalus, 3.5 to 6.5 parts of ginseng and 3.5 to 6.5 parts of weeping forsythia. The medicinal composition exerts a synergistic effect after being subjected to reasonable compatibility, and can effectively treat gastric ulcer, duodenal ulcer and erosive gastritis, and a new medication choice is provided for clinically treating peptic ulcer.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of peptic ulcer.
Background technology
Stomach, duodenal ulcer refer to that the limitation of stomach, duodenum mucosa is circular or oval holostrome is damaged, and muscularis mucosae is penetrated, and leaves fibrous scar after the healing inevitably, and the surface is covered by one deck epithelium, and muscularis mucosae can not be regenerated.It is owing to multiple reason causes that gastric acid, pepsin are destroyed to self-digestion or the gastric mucosal barrier of gastric mucosa that its cause of disease is summarized.Think that in recent years formation and the gastric Helicobacter pylori infection of ulcer also have important relationship.
Chronic erosive gastritis claims indigestion symptoms such as general rarely seen glutted, the pantothenic acid after meal of gastritis verrucosa or varioliform gastritis, belch, irregularities stomachache again.A plurality of excipuliforms appear in patient's gastric mucosa, expand folded shape or pimple sample protuberance, diameter 5～10mm, and the visible mucomembranous defect in top or umbilicus sample depression, there is erosion at the center, many no blush around the protuberance, but often with the similar erythema of size, portion sees more with gastric antrum.
The medicine of the above-mentioned disease of current treatment mostly is chemical medicine, and it is expensive, and side effect is big, and the healing required time is long.Therefore, be badly in need of a kind of economical and practical, toxic and side effects is low, and can rapid healing the medicine of above-mentioned disease.
And Chinese medicine aspect treatment of chronic diseases one to all playing an important role.Report that with Concha Arcae 75% and Radix Glycyrrhizae 25%, red in pulv, treatment gastric and duodenal ulcers, cure rate reaches 76% (" Chinese medicine voluminous dictionary " second edition, Shanghai science tech publishing house, in March, 2006, the 548th～549 page); Human Os Sepiae (life) 250g, Concha Arcae (calcined) 250g are also arranged, Radix Et Rhizoma Rhei 200g, Radix Glycyrrhizae Preparata 200g grinds to the powder, boiled water is taken after mixing it with water after meal, and each 15g, is used for the treatment of peptic ulcer (Gu Linjiang at every day 3～4 times, Os Sepiae looses and treats peptic ulcer, journal of shanghai Chinese medicine, 9 phases of calendar year 2001.Also there are human Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g to treat peptic ulcer, have certain therapeutic effect.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of peptic ulcer.
A kind of pharmaceutical composition for the treatment of peptic ulcer of the present invention, it is the preparation that is prepared from by following materials of weight proportions medicine:
Semen Coicis 14-26 part, Semen Benincasae 14-26 part, Herba Artemisiae Scopariae 10.5-19.5 part, Rhizoma Atractylodis Macrocephalae 10.5-19.5 part, Folium Perillae 7-13 part, Semen Armeniacae Amarum 7-13 part, Semen Lablab Album 7-13 part, Semen Myristicae 7-13 part, Radix Astragali 7-13 part, Radix Ginseng 3.5-6.5 part, Fructus Forsythiae 3.5-6.5 part.
Further, it is the preparation that is prepared from by following materials of weight proportions medicine:
Semen Coicis 18-22 part, Semen Benincasae 18-22 part, Herba Artemisiae Scopariae 13-17 part, Rhizoma Atractylodis Macrocephalae 13-17 part, Folium Perillae 8-12 part, Semen Armeniacae Amarum 8-12 part, Semen Lablab Album 8-12 part, Semen Myristicae 8-12 part, Radix Astragali 8-12 part, Radix Ginseng 4-6 part, Fructus Forsythiae 4-6 part.
Further preferably, it is the preparation that is prepared from by following materials of weight proportions medicine:
20 parts of Semen Coiciss, 20 parts of Semen Benincasaes, 15 parts of Herba Artemisiae Scopariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Folium Perillaes, 10 parts of Semen Armeniacae Amarums, 10 parts of Semen Lablab Albums, 10 parts of Semen Myristicaes, 10 parts of the Radixs Astragali, 5 parts of Radix Ginsengs, 5 parts of Fructus Forsythiaes.
Wherein, it is to be active component by the water of described materials of weight proportions medicine or extractive with organic solvent, adds the preparation that acceptable accessories is prepared from.
Among the present invention, Semen Coicis is the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L.var.mayuen (Roman.) Stapf.Sweet, light, cool.Return spleen, stomach, lung meridian, promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, detoxicating and resolving stagnation of pathogens.Be used for edema, beriberi, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, acute appendicitis, wart, cancerous protuberance.
Semen Benincasae is the seed of cucurbitaceous plant Fructus Benincasae.Sweet, cool.Removing heat from the lung and dissipating phlegm; The eliminating carbuncle evacuation of pus; Dampness removing.Main phlegm-heat cough; Lung abscess; The intestinal carbuncle; Nebulousurine; Leukorrhagia; Foot gas; Edema; Stranguria.
Herba Artemisiae Scopariae is the branch of quadrate part dryly of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst.Et Kit. or Herba Artemisiae Scopariae Artemisia capillaries Thunb..Bitter, hot, be slightly cold, return spleen, stomach, liver, gallbladder meridian.Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.Be used for the jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Bitter, sweet, temperature is returned spleen, stomach warp.Invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Folium Perillae is the dried leaves (or band twig) of labiate Folium Perillae Perilla frutescens (L.) Britt..Hot, warm, return lung, spleen channel.The cold expelling that induces sweat, relieving QI stagnancy in the stomach.Be used for anemofrigid cold, the cough vomiting and nausea, vomiting during pregnancy, the fish Eriocheir sinensis poisons.
Semen Armeniacae Amarum is the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. Prunus armeniaca L.var.ansu Maxim., Siberia Fructus Pruni Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..Bitter, tepor, slightly poisonous, return lung, large intestine channel.The sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.Be used for cough and asthma, fullness in the chest abundant expectoration, dryness of the intestine constipation.
Semen Lablab Album is the dry mature seed of leguminous plant Seem Lablab Album Dolichos lablab L..Sweet, tepor.Return spleen, stomach warp.Invigorating the spleen for eliminating dampness and in relieve summer heat.Be used for weakness of the spleen and stomach, inappetence, diarrhea with loose stool, leukorrhagia, heat-damp in summer is vomited and diarrhoea, abdominal distention uncomfortable in chest.
Semen Myristicae is the dry kernel of myristicaceae plant Semen Myristicae Myristica fragrans Houtt..Hot, warm, return spleen, stomach, large intestine channel.Warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents.Be used for Deficiency and coldness of spleen and stomach, incessant chronic diarrhea, abdominal distention, lack of appetite vomiting.
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Sweet, tepor.Return lung, spleen channel.Tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, detoxification evacuation of pus, expelling pus and promoting granulation.Weak in the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, the arthralgia pain numbness, carbuncle is difficult bursts, and bursts for a long time and does not hold back.
Radix Ginseng is dry root and the rhizome of Araliaceae Radix Ginseng Panax ginseng C.A.Mey..Sweet, little hardship, tepor are returned spleen, lung, the heart, kidney channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid and nourishes blood, the Fructus Alpiniae Oxyphyllae of calming the nerves.Be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb.
Fructus Forsythiae is the dry fruit of Oleaceae plant Fructus Forsythiae Forsythia suspense (Thunb.) Vahl.Bitter, be slightly cold, return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, the puckery pain of pyretic stranguria.
Pharmaceutical composition of the present invention is behind reasonable compatibility, and pharmaceutical composition of the present invention has been brought into play synergistic function, can effectively treat gastric ulcer, duodenal ulcer and erosive gastritis, selects for the clinical treatment peptic ulcer provides a kind of new medication.
The specific embodiment
Embodiment 1 preparation of drug combination of the present invention
Get Semen Coicis 20g, Semen Benincasae 20g, Herba Artemisiae Scopariae 15g, Rhizoma Atractylodis Macrocephalae 15g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Lablab Album 10g, Semen Myristicae 10g, Radix Astragali 10g, Radix Ginseng 5g, Fructus Forsythiae 5g; Add 4 times of water gagings earlier and soaked 10 minutes, decoct with water again 2 times, each 20 minutes, add 10 times of amounts of water at every turn, filter, behind the merging decocting liquid, get pharmaceutical composition decoction of the present invention.
Embodiment 2 preparation of drug combination of the present invention
Semen Coicis 14g, Semen Benincasae 26g, Herba Artemisiae Scopariae 19.5g, Rhizoma Atractylodis Macrocephalae 19.5g, Folium Perillae 13g, Semen Armeniacae Amarum 13g, Semen Lablab Album 13g, Semen Myristicae 13g, Radix Astragali 13g, Radix Ginseng 6.5g, Fructus Forsythiae 6.5g; Decoct with water 3 times, add 10 times of water gagings decoctions 5 minutes for the first time, add 8 times of water gagings for the second time and decocted 10 minutes, add 8 times of water gagings for the third time and decocted 15 minutes, filter, behind the merging decocting liquid, concentrate, add proper starch again, granulate, get medicament composition granule agent of the present invention.
Embodiment 3 preparation of drug combination of the present invention
Get Radix Ginseng 3.5g, pulverize, cross 80 mesh sieves, the Radix Ginseng powder is standby; Get Semen Coicis 26g, Semen Benincasae 14g, Herba Artemisiae Scopariae 10.5g, Rhizoma Atractylodis Macrocephalae 10.5g, Folium Perillae 7g, Semen Armeniacae Amarum 7g, Semen Lablab Album 7g, Semen Myristicae 7g, Radix Astragali 7g, Fructus Forsythiae 3.5g; Add 10 times of amount 70% alcoholic solution reflux, extract, earlier 1 time, extracted 1 hour, filter, filtrate for later use, filtering residue water again decoct 2 times, add 8 times of amounts of water at every turn, the each decoction 20 minutes, after merging ethanol extract and decocting liquid, concentrate, add an amount of microcrystalline Cellulose and dextrin and Radix Ginseng powder again, after the granulation, add an amount of magnesium stearate again, tabletting namely gets pharmaceutical composition tablet of the present invention.
Embodiment 4 preparation of drug combination of the present invention
Get Semen Coicis 22g, Semen Benincasae 18g, Herba Artemisiae Scopariae 13g, Rhizoma Atractylodis Macrocephalae 13g, Folium Perillae 8g, Semen Armeniacae Amarum 8g, Semen Lablab Album 8g, Semen Myristicae 8g, Radix Astragali 8g, Radix Ginseng 4g, Fructus Forsythiae 4g; Add 4 times of water gagings earlier and soaked 10 minutes, decoct with water again 2 times, each 20 minutes, add 10 times of amounts of water at every turn, filter, behind the merging decocting liquid, get pharmaceutical composition decoction of the present invention.
Embodiment 5 preparation of drug combination of the present invention
Get Semen Coicis 18g, Semen Benincasae 22g, Herba Artemisiae Scopariae 17g, Rhizoma Atractylodis Macrocephalae 17g, Folium Perillae 12g, Semen Armeniacae Amarum 12g, Semen Lablab Album 12g, Semen Myristicae 12g, Radix Astragali 12g, Radix Ginseng 6g, Fructus Forsythiae 6g; After the pulverizing, cross 80 mesh sieves, add microcrystalline Cellulose again, encapsulated behind the mixing, namely get medicament composition capsule agent of the present invention.
Below further show beneficial effect of the present invention by concrete test example.
Test example 1 pharmaceutical composition of the present invention is to the treatment of gastric ulcer
Gastric ulcer diagnostic criteria: upper abdomen dull pain, dull pain or burn sample pain, alleviate after taking alkalescent medicine, such pain has rhythmicity, how in 1 hour after the meal, to occur, after 1～2 hour, alleviate gradually, acid regurgitation, belch, heartburn, indigestion symptoms such as upper abdomen is glutted, nauseating, vomiting generally also can occur; The visible niche of upper digestive tract radiography; Endoscopy, can in stomach see circle or oval, the bottom is smooth, the ulcer of neat in edge, ulcer surface is greyish white or brown tongue film covers edge swelling, color and luster ruddy, smooth and soft (being the gastric ulcer active stage).Accept 56 examples altogether for medical treatment, endoscopy is confirmed as gastric ulcer.
Criterion of cure: epigastrium pain disappears, endoscopy, and visible ulcer surface white fur disappears, becomes red congested cicatrix, and visible pleat is concentrated (being cicatricial phase).
Effective standard: epigastrium pain disappears or alleviates, endoscopy, and the attenuation of tongue film, ulcer is dwindled, the blush that visible mucous epithelium is regenerated around it; Or ulcer surface almost disappears, and few thin coating (being healing stage) is arranged on it.
Therapeutic Method: get the decoction that embodiment 1 prepares, divide every day and take for 3 times, period in a medicine is avoided eating anything raw or cold, maror.
Criterion of cure: take medicine continuously by Therapeutic Method, treated 25～40 days, cure 46 examples, account for 82% of total case; Effective 10 examples account for 18% of total case.Total effective rate reaches 100%.
Test example 2 pharmaceutical compositions of the present invention are to the treatment of duodenal ulcer
Duodenal ulcer diagnostic criteria: epigastrium dull pain, causalgia, distending pain or severe pain, also can be only dull pain discomfort when hunger, or rest pain under slight or the moderate xiphoid-process appears, can be alleviated by antacid or feed, early began to occur upper abdominal pain in 1～3 hour after the meal, just alleviate then will continue to lunch as not taking medicine or taking food after, the food back also must have meal to alleviate in 2～4 hours again bitterly.Endoscopy, thick fur and filth can have petechia, sludged blood on it, the obvious congestion and edema erosion of mucosa on every side; Or tongue is still thicker, and mucosa inflammation edema alleviates on every side, and red re-epithelialize (active stage) can appear in the ulcer edge.Accept 42 examples altogether for medical treatment, endoscopy is confirmed as duodenal ulcer.
Therapeutic Method: with test example 1.
Criterion of cure: pain disappears, endoscopy, and white fur disappears, and replaces red epithelium and cicatrix; Or the re-epithelialize redness disappears cicatrix color white (being cicatricial phase).Take medicine continuously by Therapeutic Method, treated 15～20 days, cure 42 examples, account for 100% of total case.
Test example 3 pharmaceutical compositions of the present invention are to the treatment of chronic erosive gastritis
Chronic erosive gastritis diagnostic criteria: indigestion symptoms such as glutted, acid regurgitation, belch, irregularities stomachache occur, massive bleeding from upper digestive tract can occur, hematemesis, melena occur, shock, normal easily recurrence after the stopped bleeding; Endoscopy, visible gastric mucosa congestion and edema, the erosion of some lamellar, the multiple ulcer that differs in size, ulcer surface can have the fresh clot that goes out.Accept 30 examples altogether for medical treatment, endoscopy is confirmed as chronic erosive gastritis.
Therapeutic Method: with test example 1.
Criterion of cure: indigestion symptoms such as acid regurgitation, stomachache disappear, endoscopy, and no point-like or lamellar erosion, mucosa edema disappears, and gastric mucosa heals.Take medicine continuously by Therapeutic Method, treated 20～30 days, cure 30 examples, account for 100% of total case.
Model case 1
Grandson, the man, 27 years old, stomach felt that feeling of repletion is arranged, morning, time-out was obvious especially, after meal or close on ante cibum the belch phenomenon is arranged, and anorexia, body weight obviously alleviates; Through gastroscopy, confirm as erosive gastritis.
After taking medicine 7 days by test example 1 method, feeling of repletion, belch phenomenon are alleviated, and after 15 days, it is suitable with normal period that appetite has recovered, bloated sense, belch phenomenon disappear, after 25 days, through gastroscopy, ulcer surface heals, and conscious appetite, stomach feel good, and body weight is gone up.
Test example 4 pharmaceutical compositions of the present invention are to the therapeutical effect of acetic acid type gastric ulcer
Get the SD rat, fasting is after 12 hours, and rats by intraperitoneal injection 3% no barbital sodium is anaesthetized, with the alcohol cotton stick skin of sterilizing, cut the abdominal cavity open, antetheca hole body intersection serosal surface sticks the circular filter paper 30s that soaks into glacial acetic acid, diameter 5mm in glandular stomach portion, repeat 3 times, close abdomen and sew up wound, be coated with penicillin.The postoperative routine feeding was divided into 6 groups at random with animal on the 4th day, and 10 every group, male and female half and half are respectively model group (10mlkg
-1Distilled water), pharmaceutical composition of the present invention senior middle school low dose group (be followed successively by 20,40,80g crude drug/kg body weight), contrast groups (20g crude drug/kg body weight), positive drug ranitidine group (30mgkg
-1).In grouping back beginning in the 2nd day gastric infusion, administration every day 1 time, dosage is 10mlkg
-1, continuous 5 days, the last administration was taken off cervical vertebra and is put to death animal after 12 hours, cut open the belly and get stomach, wash gastric content with normal saline, stomach is fixed in 10% formaldehyde, after 15 minutes stomach is lain on the glass surface ware, measure major diameter and the minor axis of ulcer surface under the magnifier with slide gauge, and calculate ulcer surface.
Calculate ulcer inhibition rate: ulcer inhibition rate=(matched group ulcer area-administration group ulcer area)/matched group ulcer area x100%, observe the ulcer healing degree.
Pharmaceutical composition of the present invention is by embodiment 1 preparation;
The preparation method of contrast groups medicine is as follows:
Get Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g; Add 4 times of water gagings earlier and soaked 10 minutes, decoct with water again 2 times, each 20 minutes, add 10 times of amounts of water at every turn, filter, behind the merging decocting liquid, get the contrast groups decoction.
Experimental result sees Table 1.
Table 1
Annotate: compare with model group, * is p＜0.05, and * * is p＜0.01; Compare with contrast groups, △ is p＜0.05.
As shown in Table 1, pharmaceutical composition of the present invention, can effectively treat gastric ulcer, simultaneously, compare with contrast groups, though it is similar that medicine is formed, but the drug activity of pharmaceutical composition of the present invention under Isodose obviously is better than contrast groups (p＜0.05), and this just shows, pharmaceutical composition of the present invention has been brought into play synergistic function behind the rational concerted application of drugs of screening.
Test example 5 pharmaceutical compositions of the present invention are to the therapeutical effect of duodenal ulcer rat model
Get the SD rat, male and female half and half are after the anesthesia, by improvement Okabe method, get the glass tubing of internal diameter 3mm, vertical flicking injects 70% acetic acid 0.075ml, behind the 15s in this pipe on duodenum antetheca serosal surface in 0.5cm place under the pylorus, sucking-off acetic acid closes abdomen, namely gets the duodenal ulcer model.Postoperative 4 days is divided into model group (10mlkg with rat
-1Distilled water), pharmaceutical composition of the present invention senior middle school low dose group (be followed successively by 20,40,80g crude drug/kg body weight), contrast groups (20g crude drug/kg body weight), positive drug omeprazole group (converting by clinical consumption), irritate stomach respectively after 7 days, put to death rat, take out duodenum and observe ulcer inhibition rate.
Pharmaceutical composition of the present invention is by embodiment 1 preparation;
The preparation method of contrast groups medicine is as follows:
Get Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g; Add 4 times of water gagings earlier and soaked 10 minutes, decoct with water again 2 times, each 20 minutes, add 10 times of amounts of water at every turn, filter, behind the merging decocting liquid, get the contrast groups decoction.
The results are shown in Table 2.
Table 2
Annotate: compare with model group, * is p＜0.05, and * * is p＜0.01; Compare with contrast groups, △ is p＜0.05.
As shown in Table 2, pharmaceutical composition of the present invention, can effectively treat duodenal ulcer, simultaneously, compare with contrast groups, though it is similar that medicine is formed, but the drug activity of pharmaceutical composition of the present invention under Isodose obviously is better than contrast groups (p＜0.05), and this just shows, pharmaceutical composition of the present invention has been brought into play synergistic function behind the rational concerted application of drugs of screening.
In sum, pharmaceutical composition of the present invention is behind reasonable compatibility, pharmaceutical composition of the present invention has been brought into play synergistic function, can effectively treat gastric ulcer, duodenal ulcer and erosive gastritis, selects for the clinical treatment peptic ulcer provides a kind of new medication.
Claims (2)
1. pharmaceutical composition for the treatment of peptic ulcer, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
Semen Coicis 18-22 part, Semen Benincasae 18-22 part, Herba Artemisiae Scopariae 13-17 part, Rhizoma Atractylodis Macrocephalae 13-17 part, Folium Perillae 8-12 part, Semen Armeniacae Amarum 8-12 part, Semen Lablab Album 8-12 part, Semen Myristicae 8-12 part, Radix Astragali 8-12 part, Radix Ginseng 4-6 part, Fructus Forsythiae 4-6 part.
2. pharmaceutical composition according to claim 1, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
20 parts of Semen Coiciss, 20 parts of Semen Benincasaes, 15 parts of Herba Artemisiae Scopariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Folium Perillaes, 10 parts of Semen Armeniacae Amarums, 10 parts of Semen Lablab Albums, 10 parts of Semen Myristicaes, 10 parts of the Radixs Astragali, 5 parts of Radix Ginsengs, 5 parts of Fructus Forsythiaes.
3, pharmaceutical composition according to claim 1 and 2 is characterized in that: it is to be active component by the water of described materials of weight proportions medicine or extractive with organic solvent, adds the preparation that acceptable accessories or complementary composition are prepared from.
4, pharmaceutical composition according to claim 1 is characterized in that: described preparation is oral formulations.
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| CN105214035A (en) * | 2015-09-30 | 2016-01-06 | 成都恒凌科技有限公司 | One treats peptic ulcer tablet and preparation method thereof |
| CN105214037A (en) * | 2015-09-30 | 2016-01-06 | 成都恒凌科技有限公司 | The solid dispersal capsule for the treatment of peptic ulcer |
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| CN1100651A (en) * | 1994-03-15 | 1995-03-29 | 广东医学院医药科技开发中心 | Chinese herbal prepn. for curing chronic gastroenteritis and peptic gastric ulcer |
| CN1132643A (en) * | 1995-12-01 | 1996-10-09 | 冯学祯 | Medicine for diseases of liver and gall |
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Non-Patent Citations (2)
| Title |
|---|
| 于晓.胃脘痛病证的古今文献研究与学术源流探讨.《中国博士学位论文全文数据库 医药卫生科技辑》.2008,第89-120页. |
| 胃脘痛病证的古今文献研究与学术源流探讨;于晓;《中国博士学位论文全文数据库 医药卫生科技辑》;20081215;第89-120页 * |
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