CN101428111A - Traditional Chinese medicine compound formulation for treating habitual constipation and preparation method thereof - Google Patents
Traditional Chinese medicine compound formulation for treating habitual constipation and preparation method thereof Download PDFInfo
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- CN101428111A CN101428111A CNA2008100516630A CN200810051663A CN101428111A CN 101428111 A CN101428111 A CN 101428111A CN A2008100516630 A CNA2008100516630 A CN A2008100516630A CN 200810051663 A CN200810051663 A CN 200810051663A CN 101428111 A CN101428111 A CN 101428111A
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Abstract
The invention relates to a traditional Chinese medicine compound preparation for treating habitual constipation and a preparation method thereof, thereby overcoming the shortcomings that the treatment drugs which are mainly based on diarrhea in the past can cause the substantial loss of body water and electrolyte and cause the disorders of the water and the electrolyte of the body. The traditional Chinese medicine compound preparation is composed of the following pharmaceutical raw materials by parts by weight: 1-5 parts of aloe extract, 20-35 parts of largehead atractylodes rhizome extract and 15-25 parts of desertliving cistanche extract. The preparation method is as follows, the alcohol extraction of aloe and the water extraction of medicinal active ingredients of largehead atractylodes rhizome and desertliving cistanche extract are firstly carried out, and then dry powder is mixed according to the proportion. The invention has the advantages that the traditional Chinese medicine compound preparation is composed of the traditional Chinese medicines with the effects of purgation, strengthening spleen and reinforcing insufficiency, thereby having a certain purgation effect and better nourishing effect, being capable of carrying out the comprehensive treatment of the constipation from five aspects of benefiting qi, resolving, pushing, lubricating and conditioning against the local symptoms and the overall symptoms of a patient, achieving the purposes of not damaging vital qi by purgation and not causing stagnation by nourishment, eliminating the disease cause, improving the symptoms and restoring the normal intestinal mobility and the defecation physiological function.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of the constipation of deficiency of YIN dryness of the intestine and preparation method thereof.
Background technology
Constipation is meant that feces overstays at enteral, and feces is dry and hard, matter is hard, difficult defecation or defecation time prolong.Be also referred to as habitual constipation, the constipation of the special property sent out, simple property constipation clinically.
With the passing of time constipation can cause hemorrhoid, anal fissure, so that have blood in stool:
In recent years, constipation patient is clinically and increases trend gradually, its cause of disease complexity.At present, the treatment of this disease does not still have specific medicament, and the method for in the past treating constipation is rushing down mostly, though cathartic can relieving constipation, often occurs the secondary constipation after the medication again.Simultaneously, cathartic can make health lose large quantity of moisture and electrolyte, causes that easily the power and water of body is separated the matter disorder.
Motherland's medical science is thought: large intestine is the organ in charge of transportation, changes thing and here goes out.Post transmits waste matter, and with lung be the exterior and the interior, lung qi is respectful to fall, the defeated cloth of body fluid is normal, then large intestine internal organs gas is unobstructed, coming in and going out, there have to be normal.If work and rest mistakes degree, take good care of oneself improper, intemperance of taking food or the pungent savoury of surfeit etc., cause damp and hot heresy to pent up large intestine, body fluid loses void or not enough; Or because of the local operation of anus back influences mechanism of qi, cause in venation block, qi depression to blood stasis, the turbid pathogen waste matter stagnation intestinal, FU QI being obstructed, the difficult row of constipation forms the constipation disease.So treatment blood stasis dispelling intestinal stasis relieving, the purging FU-organs of regulating the flow of vital energy, methods of loosening bowel to relieve constipation of adopting more.
The treatment by Chinese herbs constipation not only has superiority aspect relieving constipation, can adjust gastrointestinal dysfunction simultaneously, and patient's physical condition is improved.Especially to the weakness constipation, the adjustment through to patient's virtual image can improve weak state effectively, strengthens the viscera function that comprises the defecation ability.These all are to use Western medicine unapproachable merely.Because the Chinese medicine good effect, few side effects is accepted by the patient easily, therefore treats constipation based on Chinese medicine.
Summary of the invention
The purpose of this invention is to provide a kind of compound Chinese medicinal preparation that is used for the treatment of habitual constipation, overcame in the past and cause health to lose moisture and electrolyte in a large number, cause that the power and water of body separates the deficiency of matter disorder based on the curative that rushes down.
Another object of the present invention provides a kind of manufacturing method for above mentioned medicine, make this medicine can industry
The present invention is made up of following bulk drugs:
1-5 parts of Aloe extracts, 20-35 parts of Rhizoma Atractylodis Macrocephalae extracts, 15-25 parts of Herba Cistanches extracts.
Medicine optimum feed stock parts by weight proportioning of the present invention is: 2.5 parts of Aloe extracts, 26.5 parts of Rhizoma Atractylodis Macrocephalae extracts, 21 parts of Herba Cistanches extracts.
Medicine of the present invention is oral medicine, and dose is counted 2g/ day with above-mentioned active constituents of medicine mixture scale, divide 2 times oral.
The present invention in conjunction with clinical practice, carries out Analysis and Screening according to the principle of differentiation of tcm.Follow on compatibility of drugs that YIN nourishing and the production of body fluid promoting is moisturized, the effect of clearing away heat and resolving stagnation of food, diarrhea relieving constipation, invigorating the spleen and benefiting QI, Hezhong Huazhi, reinforcing the kidney and supporting YANG.Existing certain diarrhea effect, benefiting action is preferably arranged again, reach to the purpose of " rush down and just do not hinder; mend unlikely plug ", simultaneously follow " treating both the principal and secondary aspects of a disease " principle on the principle of treatment, at patient's local symptom and integrality, from QI invigorating, fortuneization, promotion, lubricate, nurse one's health five aspects Comprehensive Treatment is carried out in constipation, alleviate patient's misery, form treatment constipation new concept.
Aloe is a monarch drug.Aloe, the nature and flavor bitter cold is gone into liver, the heart, spleen channel.Its cold dampness of purging heat.Has removing heat from the liver, the function of diarrhea relieving constipation.
Rhizoma Atractylodis Macrocephalae preparata, Herba Cistanches are all ministerial drug.The Rhizoma Atractylodis Macrocephalae is warm in nature, and bitter in the mouth is sweet, goes into spleen, stomach warp, have air making-up and spleen enlivening,, hidroschesis, antiabortive effect.Herba Cistanches has tangible defecating feces excretion, can improve enterokinesia, suppresses the moisture absorption of large intestine, shortens defecation time.To senility habitual constipation, the empty constipation of body and puerpera's puerperal constipation are evident in efficacy, are longer than the treatment withered constipation in dryness of the intestine Tianjin.。Simultaneously Herba Cistanches can excited hypophysis, adrenal cortex or the effect of similar adrenocortical hormone sample is arranged, and regulates the effect of body's immunity.
All medicines are harmonious, and have the intestinal stasis relieving of purging heat, and blood stasis dispelling is clear rotten, loosening bowel to relieve constipation and do not hinder healthy energy, get rid of the turbid pathogen waste matter and the characteristics of not suffering from diarrhoea, effecting a permanent cure and transferring pivot to set upright.
The preparation method of medicine of the present invention comprises the steps:
(1) gets the chopping of Aloe cured leaf, in water-bath, heat leaching, behind the recovery ethanol, get paste, place round-bottomed flask, add water and make its dissolving with ethanol.Add benzene, water-bath refluxes.After being cooled to room temperature benzene liquid is placed separatory funnel, washing twice behind anhydrous sodium sulfate dehydration, is reclaimed benzene to doing, and gets powder;
(2) get Rhizoma Atractylodis Macrocephalae distilled water immersion, decoct with water extraction afterwards, pour out decocting liquid, the multilamellar filtered through gauze, the extracting solution concentrating under reduced pressure is concentrated into thick paste, and dry, pulverizing gets dry powder.
(3) get the Herba Cistanches distilled water immersion, decoct with water extraction afterwards, pour out decocting liquid, the multilamellar filtered through gauze, the extracting solution concentrating under reduced pressure is concentrated into thick paste, and dry, pulverizing gets dry powder.
4, get Aloe extract 1-5 weight portions that step (1) obtains, Rhizoma Atractylodis Macrocephalae extract 20-35 weight portions that step (2) obtains, Herba Cistanches extract 15-25 weight portion mix homogeneously that step (3) obtains medicine of the present invention.
The present invention is according to practice of pharmacy and add adjuvant and/or the figuration material preparation becomes satisfactory pharmaceutical preparation, comprises granule, pill, capsule, soft capsule, tablet, mixture etc.
Good effect of the present invention is formed by capturing class, spleen invigorating class and deficiency tonifying kind Chinese medicine, local symptom and whole symptom at the patient, from QI invigorating, fortuneization, promotion, lubricated, five aspects of conditioning Comprehensive Treatment is carried out in constipation, alleviate the patient suffering, form the new concept of treatment constipation.
YANG invigorating: constipation patient, especially person in middle and old age's constipation patient often all has deficiency of kidney yang, timid cold cold extremities occurs, and vertigo and tinnitus is in the defecation room, though there is the defecation of just anticipating extremely to require great effort.Herba Cistanches has the kidney invigorating and essence nourishing effect, helps strengthening patient's system, obviously improves the large intestine motive force, is convenient to feces and gets rid of.
Fortuneization: select the Rhizoma Atractylodis Macrocephalae with invigorating spleen and reinforcing stomach for use, the Rhizoma Atractylodis Macrocephalae can obviously improve gastrointestinal secretory function and wriggling function, makes gastrointestinal body fluid secretion vigorous, improves the fortune function of digestive system, makes health healthy energy obtain helping, can not only relieving constipation, and can facilitating digestion.
Promote: the present invention has good intestinal impetus.Improve the intestinal digestive function, increase the contractile function of intestinal tube, make large intestine keep more water simultaneously, make the just qualitative change of feces soft, easily discharge.
Lubricated: lubricating function of the present invention is different with relieving constipation lubricant (as liquid paraffin, glycerin etc.) commonly used, and it is kind logical that Herba Cistanches has the sliding many profits of matter, has purging and intestine lubricating action, reduces enteral abnormal fermentation and promote inflammatory exudate to discharge.
Conditioning: the present invention has the good conditioning function, makes body recovery and keeps equilibrium between yin and yang, and QI and blood is vigorous.A healthy wind prevails owing to body, and various physiological functions improve thereupon, fundamentally solves the constipation problem.
In a word, the present invention has taken into account row and has rushed down relieving constipation and promote the production of body fluid tonification thought, existing certain diarrhea function has benefiting action preferably again, accomplished " rush down and just do not hinder; mend and do not block ", accomplished to eliminate the cause of disease, improved symptom, recovered the physiological function of normal bowel power and defecation, thereby constipation has been had good efficacy.The invention belongs to pure Chinese medicinal preparation simultaneously, safety range is wide, reduces patient's dependency, the secondary constipation can not occur, and the patient has good tolerability and compliance to medicine.For the ease of understanding the present invention at the medical value aspect the treatment constipation, concrete pharmacological experiment is as follows:
1. to the influence of normal rat intestine road motor function
Get 40 of wistar rats, male and female half and half are divided into the normal control group at random, are subjected to the high, medium and low dosage group of reagent, totally four groups, 10 every group.Handle experiment according to document, observe defecation time, total number of defecation and 4h excrement are heavy in the record administration 4h.The results are shown in Table 1.
Table 1 be subjected to reagent to the influence of normal rat intestine motor function (x ± S, n=10)
Compare with the normal control group: ※ p＜0.05, ※ ※ p＜0.01.
Be subjected to reagent that the defecation time of normal rat is obviously shortened as can be seen from Table 1, defecation grain number obviously increases, and is dose-dependence, and promptly high dose is better than low dosage.
2. the rat model intestinal is promoted the influence of function
Add according to literature method and to carry out modeling: irritate stomach with compound diphenoxylate 50mg/kg, continuous 10 days, during normal diet, form the constipation model.With 50 model wistar rats be divided at random the normal control group, the experiment processing method the same.The results are shown in Table 2.
Table 2 be subjected to reagent to the influence of rat model intestine movement function (x ± S, n=10)
Compare with model control group: ※ p＜0.05, ※ ※ p＜0.01.
Be subjected to reagent can promote the defecation of constipation rat as shown in Table 2, wherein remarkable with the high dose group effect.
3. intestinal charcoal end advances experiment to the normal mouse intestinal charcoal propulsive influence in end
40 mices are divided into the normal control group at random, are subjected to the high, medium and low dosage group of reagent, 10 every group, every group of fasting 24h.Handle according to document, calculate charcoal end propelling rate.
Table 3 be subjected to reagent to propulsive influence of normal mouse intestinal carbon powder (x ± S, n=10)
Compare with the normal control group: ※ p＜0.05, ※ ※ p＜0.01.
Each administration group has been compared significant difference (p＜0.05 or p＜0.01) with the normal control group as shown in Table 3, but the strongest with the high dose group effect.Illustrate and be subjected to reagent to have the good propulsive effect of promotion normal rat intestinal.
4. to the propulsive influence in end of constipation model mice intestinal charcoal
Get after the constipation modeling 50 of kunming mices, be divided into normal control group, model control group at random, be subjected to the high, medium and low dosage group of reagent, 10 every group, every group of mice fasting 24h.The experiment processing method is the same.The results are shown in Table 4.
Table 4 be subjected to reagent to propulsive influence of constipation model mice intestinal carbon powder (x ± S, n=10)
Compare with the normal control group: ※ p＜0.05, ※ ※ p＜0.01.
Each administration group has been compared significant difference (p＜0.05 or p＜0.01) with model control group as shown in Table 4.Illustrate all had by reagent to promote the propulsive effect of constipation rat intestinal, wherein with effect the best of high dose group.
5. constipation rat model intestinal water content is tested
Get 50 of constipation model wistar rats, be divided into normal control group, model control group at random, be subjected to the high, medium and low dosage group of reagent, 10 every group, every group of fasting 24h.Normal control group and model control group are irritated the stomach feedwater with the volume of 0.03ml/g respectively, are subjected to the high, medium and low dosage group of reagent to irritate stomach by 0.6g/kg, 0.3g/kg, 0.15g/kg respectively and are subjected to reagent.Handle the moisture of by formula calculating small intestinal, large intestine according to literature method.The results are shown in Table 5.
Table 5 be subjected to reagent to the influence of constipation rat model intestinal water content (x ± S, n=10)
Compare with the normal control group: ※ p＜0.05, ※ ※ p＜0.01.
Each administration group has been compared significant difference (p＜0.01) with model control group as shown in Table 5, illustrates that each administration group all can increase the intestinal water content of constipation rat. and wherein the high dose group effect is best, and next coming in order are middle dosage group and low dose group.
6. anxious poison experiment
Acute toxicity (maximum tolerated dose): observed 7 no obvious adverse reaction and death after the mice lavage administration continuously; Its mouse stomach maximum tolerated dose is 186.4g (crude drug)/kg, and toxicity is lower, is equivalent to 125.31 times of clinical consumption.The result shows that the toxicity of Chinese medicine preparation of the present invention is less, and medicinal safety is higher.
The specific embodiment
Embodiment 1
1, Aloe medicinal active ingredient extraction: get the chopping of Aloe cured leaf, use the ethanol of 10 times of weight of Aloe cured leaf to heat 55 ℃ of leachings 6 hours in water-bath, behind the recovery ethanol, get paste, place round-bottomed flask, the water that adds 2 times of weight of gained paste makes its dissolving.The benzene that adds 0.8 times of weight of gained paste, water-bath refluxes.After being cooled to room temperature benzene liquid is placed separatory funnel, washing twice, add 0.1 times of weight anhydrous sodium sulfate dehydration of gained paste after, reclaim benzene to doing, powder, the gained powder is further pulverized, cross 100 mesh sieves, standby.
2, Rhizoma Atractylodis Macrocephalae medicinal active ingredient extracts: get the Rhizoma Atractylodis Macrocephalae, use distilled water immersion 12 hours, add to the water of 10 times of weight of the Rhizoma Atractylodis Macrocephalae, decoct and extract twice, each 2 hours, pour out decocting liquid, the multilamellar filtered through gauze, the extracting solution concentrating under reduced pressure is concentrated into thick paste, drying is pulverized, and crosses 100 mesh sieves, and is standby.
3, the Herba Cistanches medicinal active ingredient extracts.Identical with Rhizoma Atractylodis Macrocephalae medicinal active ingredient extracting method.
4,, 2.5 parts of Aloe extracts, 26.5 parts of Rhizoma Atractylodis Macrocephalae extracts, 21 parts of mix homogeneously of Herba Cistanches extract, incapsulate, must treat the medicine capsule of the present invention that habitual constipation is controlled.
Embodiment 2
1, the method for pressing embodiment 1 is extracted Aloe, the Rhizoma Atractylodis Macrocephalae, Herba Cistanches medicinal active ingredient,
2, get 5 parts in Aloe extract powder, 20 parts in Rhizoma Atractylodis Macrocephalae extract powder, 25 parts in Herba Cistanches extract powder, 8 parts of starch, 0.1 part of magnesium stearate,, get tablet by common film-making technology film-making.
Embodiment 3
1, the method for pressing embodiment 1 is extracted Aloe, the Rhizoma Atractylodis Macrocephalae, Herba Cistanches medicinal active ingredient,
2, get 1 part in Aloe extract powder, 35 parts in Rhizoma Atractylodis Macrocephalae extract powder, 15 parts in Herba Cistanches extract powder, 10 parts in dextrin, add an amount of stevioside again, stir, an amount of with 80% ethanol, make dissolved granule 1000g, dry, granulate, packing is promptly.
Claims (3)
1, a kind of compound Chinese medicinal preparation that is used for the treatment of habitual constipation, it is characterized in that: the raw material by following weight portion is formed:
1-5 parts of Aloe extracts, 20-35 parts of Rhizoma Atractylodis Macrocephalae extracts, 15-25 parts of Herba Cistanches extracts.
2, a kind of compound Chinese medicinal preparation that is used for the treatment of habitual constipation according to claim 1, it is characterized in that: raw materials used parts by weight are: 2.5 parts of Aloe extracts, 26.5 parts of Rhizoma Atractylodis Macrocephalae extracts, 21 parts of Herba Cistanches extracts.
3, the preparation method of a kind of claim 1 or 2 the compound Chinese medicinal preparation that is used for the treatment of habitual constipation is characterized in that comprising the steps:
(1) gets the chopping of Aloe cured leaf, in water-bath, heat leaching, behind the recovery ethanol with ethanol, get paste, place round-bottomed flask, add water and make its dissolving, add benzene, water-bath refluxes, after being cooled to room temperature benzene liquid is placed separatory funnel, washing twice is behind anhydrous sodium sulfate dehydration, reclaim benzene to doing, get powder;
(2) get Rhizoma Atractylodis Macrocephalae distilled water immersion, decoct with water extraction afterwards, pour out decocting liquid, the multilamellar filtered through gauze, the extracting solution concentrating under reduced pressure is concentrated into thick paste, and dry, pulverizing gets dry powder;
(3) get the Herba Cistanches distilled water immersion, decoct with water extraction afterwards, pour out decocting liquid, the multilamellar filtered through gauze, the extracting solution concentrating under reduced pressure is concentrated into thick paste, and dry, pulverizing gets dry powder;
(4) get Aloe extract 1-5 weight portions that step (1) obtains, Rhizoma Atractylodis Macrocephalae extract 20-35 weight portions that step (2) obtains, Herba Cistanches extract 15-25 weight portion mix homogeneously that step (3) obtains medicine of the present invention.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764364A (en) * | 2012-08-20 | 2012-11-07 | 广东丸美生物技术股份有限公司 | External medicine for curing constipation and method for preparing same |
| CN103417674A (en) * | 2013-07-16 | 2013-12-04 | 李青平 | Medicine composition for treating constipation and preparation method and specific uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1045722C (en) * | 1993-01-01 | 1999-10-20 | 广州中药一厂 | Compound Chinese patent medicine for treating constipation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764364A (en) * | 2012-08-20 | 2012-11-07 | 广东丸美生物技术股份有限公司 | External medicine for curing constipation and method for preparing same |
| CN102764364B (en) * | 2012-08-20 | 2014-01-29 | 广东丸美生物技术股份有限公司 | External medicine for curing constipation and method for preparing same |
| CN103417674A (en) * | 2013-07-16 | 2013-12-04 | 李青平 | Medicine composition for treating constipation and preparation method and specific uses thereof |
| CN103417674B (en) * | 2013-07-16 | 2015-05-20 | 北京恒清堂医药科技有限公司 | Medicine composition for treating constipation and preparation method and specific uses thereof |
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| CN101428111B (en) | 2011-06-22 |
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