CN104398654A - Traditional Chinese medicine healthcare product for treating constipation of middle aged and elderly people and preparation method of traditional Chinese medicine healthcare product - Google Patents
Traditional Chinese medicine healthcare product for treating constipation of middle aged and elderly people and preparation method of traditional Chinese medicine healthcare product Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine healthcare product for treating constipation of middle aged and elderly people and a preparation method of the traditional Chinese medicine healthcare product, aiming at providing a traditional Chinese medicine healthcare product which has the effects of nourishing yin and tonifying the spleen as well as lubricating the intestines and relaxing bowel and is used for treating constipation of middle aged and elderly people. According to the technical scheme, the traditional Chinese medicine healthcare product is prepared from the following traditional Chinese medicine raw materials in percentage by weight: 14-50% of cistanche, 14-50% of atractylodes macrocephala, 12-30% of immature bitter orange, 12-30% of fructus cannabis and 12-30% of dried rehamnnia roots, wherein the sum of the percentages of the components is 100%. The traditional Chinese medicine healthcare product belongs to the technical field of traditional Chinese medicines.
Description
Technical field
The present invention relates to a kind of health product, specifically, be a kind of Chinese medicine health care product being used for the treatment of middle-aged and elderly people constipation, the invention still further relates to the preparation method of this Chinese medicine health care product.
Background technology
Constipation refer to difficult defecation or effort, defecation not freely, just secondary very little, feces is dry and hard and amount is few.Normal condition servant weekly defecation is no less than 3 times, constipation patient weekly defecation be less than 3 times, defecation effort time-consuming.Owing to increasing along with the age, the appetite of old people and physical exertion are obviously few, gastro-intestinal secretion Digestive system reduces, the tension force of intestinal tube and wriggle weakness, abdominal cavity and pelvic diaphragm muscle weak, anal external sphincter weakens, gastrocolic reflex weakens, Rectal Sensitivity declines, and food is overstayed at enteral, and excessive water absorbs and causes constipation.Old people's loss of tooth, the meticulous food of low slag is eaten in happiness, or a few patients figure is conveniently saved trouble, and diet is simple, lacks crude fibre, faecal volume is reduced, and viscosity increases, and slow down in enteral motion, excessive water absorbs and causes constipation.In addition, disease reason often loses defecation reflex because of alzheimer disease or dysthymia as high old man, causes constipation.Senile constipation belongs to constipation, is non-general disease or the constitutional persistence constipation caused by intestinal tract disease.Modern medicine think the senile constipation cause of disease have following some: 1. dietary effects; 2. hypokinesia; 3. bowl evacuation habit; 4. transfer function obstacle; The factor such as 5. intestinal is outlet obstructed.
Research is pointed out, extract more than 8000 old man of more than 60 years old to domestic 6 cities (Beijing, Shanghai, Guangzhou, Chengdu, Xi'an, Shenyang) to investigate, result display constipation of old people total prevalence rate is 11.5%, along with the increase at age, prevalence increases, and old man's prevalence of more than 85 years old reaches 19.5%.Along with the impact of the factors such as living standard, life style, dietary structure, the increasing sharply of aging population in addition, the incidence rate of China's middle-aged and elderly people constipation can in the trend constantly risen.This disease not only seriously reduces life of elderly person quality, and can increase the weight of original base pathological changes, even also can bring out apoplexy, acute myocardial infarction etc., therefore not be sneezed at.
Modern medical therapy constipation, mainly based on cathartic, comprises displacement type cathartic, softening agent, lubricant, water absorbing agent (saline cathartic and hyperosmolar agent), irritant laxative; And coloclysis or suppository; Prokinetic drug etc.According to related medical, expert points out, long-term taking or abuse irritant laxative may cause potentiality serious in body disorderly.As hypokalemia, chronic low blood sodium and progressivity renal insufficiency etc.Also may cause the change of intestinal wall cell function and form, thus cause the damage of large intestine epithelium.Also may cause the vicious cycle that this kind of cathartic is relied in addition, cause serious constipation.
Constipation is called " spleen-constipation ", " no defecation " etc. by motherland's medical science, senile constipation is also called " old man is secret ", " rear unfavorable ", " difficulty in defecation " etc., Huangdi's Internal Classics day: " QI and blood of the old declines; its muscle is withered; stagnant QI-passage ", " disease is controlled constipation because of arteries and veins and discussed " points out: " year, high the moon consumed, and the dry Tianjin of blood exhausts, constipation ".The sick position of primary disease is at large intestine, and the closest with spleen kidney relation, body is empty with age, deficiency of spleen and stomach, and kidney qi virtual loss then descends unit not warm, and five liquid are not changed, and intestinal loses and moistens and constipation; Spleen loses transporting then no resource of generating and transforming QI and blood, and then large intestine conduction is unable for the deficiency of vital energy, and the deficiency of vital energy then causes blood unable, and with the passing of time, blood stasis does not go blood stasis, fresh blood not life, can hyperamization empty, blood deficiency then body fluid is exhausted, and large intestine loses and makes moist, dry and astringent being difficult to resolve and form constipation of defecating.
The effect of Chinese medicine in middle-aged and elderly people constipation therapy obtains admitting comparatively widely, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, is emphatically the balance of reconditioner body yang blood and qi internal organs, fundamentally removes the internal and external factor that primary disease occurs and develops.It not only has superiority in relieving constipation, can adjust gastrointestinal dysfunction simultaneously, and the physical condition of patient is fundamentally improved.General treatment emplastic owner will comprise containing Anthraquinone laxative on the market now at present, comprises Radix Et Rhizoma Rhei, Folium Sennae, Aloe etc., and these medicines, by stimulating colonic mucosa and myenteric nerve plexus, promote enterokinesia and mucilage secretion, thus promote defecation.They are generally rapid-action, and obviously, low price, is easy to buy, has become the Long-term selection of many person in middle and old age's constipation patients in effect.But these irritant laxatives can cause watery diarrhea and stomachache, long-term or excessive use can cause the electrolyte disturbance such as hyponatremia, hypokalemia, and protein losing enteropathy, also can damage enteric nervous system, cause drug resistance and drug dependence.In addition, part irritant purgative also can cause melanosis coli, and whether this pathological changes is carcinogenic, still disputable at present.And rush down lower class medicine for a long time with can the impairment of QI-blood, damage body fluid, make originally not enough QI and blood, body fluid loses more.Therefore middle-aged and elderly people constipation patient should avoid this kind of medicine of long-term taking.And treatment constipation drug prescription mostly is large prescription on the market, owing to there is various active composition in Chinese medicine, and likely only have in multiple a kind of to be treatment constipation, to cause the drawback that multi-flavor medicine has side effect large, even single medicinal material is all be main mainly with cathartic, long-term taking can cause constipation to increase the weight of.Make it the Chinese patent medicine still lacking desirable treatment middle-aged and elderly people constipation so far, be difficult to the characteristic embodying this refractory disease of Chinese medicine middle-aged and elderly people constipation.
Summary of the invention
The object of this invention is to provide one and there is YIN nourishing spleen invigorating, effect of relaxing bowel, be used for the treatment of the Chinese medicine health care product of middle-aged and elderly people constipation.Another object of the present invention is to provide a kind of preparation method of above-mentioned Chinese medicine health care product.
Last technical scheme of the present invention is such: the Chinese medicine health care product of this treatment middle-aged and elderly people constipation, it is the health product be made up of the raw material of Chinese medicine of following weight percentage ratio: Herba Cistanches 14 ~ 50%, the Rhizoma Atractylodis Macrocephalae 14 ~ 50%, Fructus Aurantii Immaturus 12 ~ 30%, Fructus Cannabis 12 ~ 30%, Radix Rehmanniae 12 ~ 30%, each component sum is 100%.
Further, the Chinese medicine health care product of above-mentioned treatment middle-aged and elderly people constipation, the percentage by weight of described raw material of Chinese medicine is good with following ratio: Herba Cistanches 20 ~ 35%, the Rhizoma Atractylodis Macrocephalae 20 ~ 35%, Fructus Aurantii Immaturus 12 ~ 25%, Fructus Cannabis 12 ~ 25%, Radix Rehmanniae 12 ~ 25%, each component sum is 100%.
Above-mentioned a kind of Chinese medicine health care product for the treatment of middle-aged and elderly people constipation, described medicament is any one of granule or capsule or tablet or oral solutions etc.; But be good with oral solutions or granule, particularly oral solutions is better.
In prescription of the present invention, Herba Cistanches is sweet, salty, temperature.Returning kidney, large intestine channel, the kidney warming relieving constipation, be the medicine of kidney channel blood system, have warming and recuperating the kidney-YANG, the effect of blood enriching and dryness moistening, YANG invigorating gas and not dry, yin nourishing blood and oiliness, is principal agent.Fructus Aurantii Immaturus is bitter, pungent, sour, temperature.Return spleen, stomach warp, dispelling the stagnated QI removing food stagnancy, rush down expectorant intestinal stasis relieving; The Rhizoma Atractylodis Macrocephalae is bitter, sweet, and temperature, returns spleen, stomach warp, spleen reinforcing dampness, QI invigorating and blood producing, and in disappear stagnant; Fructus Cannabis is sweet, flat, and return spleen, stomach, large intestine channel, loosening bowel to relieve constipation, three medicines are referred and synthesized, reaching tonify without causing stagnation, disappear just do not hindering, the merit of promoting digestion and removing stagnation, relieving distension and oppression, help with Radix Rehmanniae sweet, cold, GUIXIN, liver, kidney channel.Clearing away heat and promoting production of body fluid, yin nourishing intestine moistening; The combination of all medicines, plays the effect of playing YIN nourishing spleen invigorating, loosening bowel to relieve constipation altogether altogether, and can be used for the constipation for the treatment of middle-aged and elderly people, disease sees awareness of defecation and just secondary minimizing, and defecation is difficult or defecation is smooth, or has just matter dry and hard, abdominal distention, stomachache, weak etc.Full side's compatibility is precise and appropriate, mend and rush down and combine, disappear just do not hindering, nourishing YIN to relieve dryness, the pathogenic characteristic of middle-aged and elderly people constipation deficiency of spleen and stomach, QI and blood body fluid deficiency just, therefore good effect can be obtained.
After of the present invention, a technical scheme is such: the preparation method of the Chinese medicine health care product of this treatment middle-aged and elderly people constipation, comprises the following steps:
(1) above-mentioned gomi herbs, weighs by mass percentage, for subsequent use;
(2) get the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Fructus Cannabis, the water adding 10 times amount distills 2 hours, and collect the volatile oil in distillate, another device saves backup, and liquid filtering is for subsequent use, and medicinal residues add water 6 times and extract 1.5 hours, and filter, merging filtrate is for subsequent use;
(3) get Herba Cistanches and Radix Rehmanniae, water extraction twice, first time adds the water extraction 2 hours of 8 times amount, second time adds the water extraction 2 hours of 6 times amount, filters, merges with front step filtrate, vacuum concentration is to relative density 1.25-1.30 (60 DEG C) clear paste, for subsequent use.
(4) get above-mentioned clear paste, make granule or capsule or tablet or oral solutions by Chinese patent medicine routine fashion.
Above-mentioned Chinese medicine health care product of the present invention is clinical proved recipe, be used for the treatment of middle-aged and elderly people constipation, disease sees awareness of defecation and just secondary minimizing, difficult or the defecation of defecation is smooth, or has just matter dry and hard, abdominal distention, stomachache, weak etc., its determined curative effect, preparation technology is easy to stable uniform simultaneously, quality controllable, meets the developing direction of modernization of cmm.The present invention is under the safety ensureing prescription and effectiveness prerequisite, and adopt modernization of Chinese medicine technique, be made into oral solutions, it has good fluidity, and size is even, is easy to subpackage; Little by wet, heat, air impact; Storage is convenient, and production technology is simple, be convenient to the advantages such as mechanized operation, the stability of medicine can also be increased, good absorbing, improve the bioavailability of this Chinese medicine, the crowd of being suitable for is extensive, middle-older patient taking convenience, also can cover the bad smell of medicine, makes its medication demand that more can meet modern and custom.
Detailed description of the invention
Mode below by embodiment further illustrates the present invention, but does not form any limitation of the invention, and the amendment of anyone limited number of time made in right of the present invention is still in right of the present invention.
A kind of Chinese medicine health care product for the treatment of constipation of old people of the present invention, the medicament adopting the raw material of Chinese medicine of following weight percentage ratio to make, all has good curative effect: Herba Cistanches 14 ~ 50%, the Rhizoma Atractylodis Macrocephalae 14 ~ 50%, Fructus Aurantii Immaturus 12 ~ 30%, Fructus Cannabis 12 ~ 30%, Radix Rehmanniae 12 ~ 30%
The method of preparation comprises the steps:
(1) above-mentioned gomi herbs, weighs by mass percentage, for subsequent use;
(2) get the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Fructus Cannabis, the water adding 10 times amount distills 2 hours, and collect the volatile oil in distillate, another device saves backup, and liquid filtering is for subsequent use, and medicinal residues add water 6 times and extract 1.5 hours, and filter, merging filtrate is for subsequent use;
(3) get Herba Cistanches and Radix Rehmanniae, water extraction twice, first time adds the water extraction 2 hours of 8 times amount, second time adds the water extraction 2 hours of 6 times amount, filters, merges with front step filtrate, vacuum concentration is to relative density 1.25-1.30 (60 DEG C) clear paste, for subsequent use.
(4) get above-mentioned clear paste, make granule or capsule or tablet or oral solutions by Chinese patent medicine routine fashion.
Wherein:
The preparation of A, granule:
Get above-mentioned clear paste, add appropriate amount of auxiliary materials, mixing, adds the appropriate wetting agent (ethanol of water or variable concentrations, determine according to different batch clear paste) prepare soft material, granulation of sieving, 75 DEG C of oven dry, granulate, evenly spray into above-mentioned volatile oil, airtight room temperature preservation 30 minutes, take out, subpackage, packaging, both, or after granulate, get the powder of appropriate differential absorbed on silica gel volatile oil, always mix with granule, take out, subpackage, packaging, both.
The preparation of B, capsule:
Get above-mentioned clear paste, 70 DEG C of vacuum dryings, add appropriate micropowder silica gel and pulverize, then get appropriate micropowder silica gel and volatile oil mix, then get appropriate amount of auxiliary materials and always mix, incapsulate shell, subpackage, pack, both must.
The preparation of C, tablet:
Get above-mentioned clear paste, add appropriate amount of auxiliary materials, mixing, add appropriate wetting agent (ethanol of water or variable concentrations is determined according to different batch clear paste) and prepare soft material, granulation of sieving, 75 DEG C of oven dry, granulate, gets the powder of appropriate differential absorbed on silica gel volatile oil, always mix with granule, magnesium stearate, take out, tabletting, subpackage, packaging, both.
The preparation of D, oral solutions:
Get above-mentioned clear paste, add the dilution of appropriate purified water, then add appropriate sodium benzoate (pharmaceutical grade food antiseptics), simple syrup (correctives), disodium edetate, dissolve, be diluted to prescribed volume, subpackage by purified water, packaging, to obtain final product.
One of preparation of embodiment 1 granule
Raw medicinal material prescription: Herba Cistanches 400g, Rhizoma Atractylodis Macrocephalae 400g, Fructus Aurantii Immaturus 400g, Fructus Cannabis 400g, Radix Rehmanniae 400g
Preparation method:
(1) above-mentioned gomi herbs, weighs by mass percentage, for subsequent use;
(2) get the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Fructus Cannabis, the water adding 10 times amount distills 2 hours, and collect the volatile oil in distillate, another device saves backup, and liquid filtering is for subsequent use, and medicinal residues add water 6 times and extract 1.5 hours, and filter, merging filtrate is for subsequent use;
(3) get Herba Cistanches and Radix Rehmanniae, water extraction twice, first time adds the water extraction 2 hours of 8 times amount, second time adds the water extraction 2 hours of 6 times amount, filters, merges with front step filtrate, vacuum concentration is to relative density 1.25-1.30 (60 DEG C) clear paste, for subsequent use.
(4) get above-mentioned clear paste, add appropriate amount of auxiliary materials, mixing, adds the appropriate wetting agent (ethanol of water or variable concentrations, determine according to different batch clear paste) prepare soft material, granulation of sieving, 75 DEG C of oven dry, granulate, evenly spray into above-mentioned volatile oil, airtight room temperature preservation 30 minutes, take out, subpackage, packaging, both, or after granulate, get the powder of appropriate differential absorbed on silica gel volatile oil, always mix with granule, take out, subpackage, packaging, both.The specification of obtained granule is: 8g/ bag.Usage and dosage is: oral, one time 1 bag, 2 ~ 3 times on the one.
The preparation two of embodiment 2 granule
Raw medicinal material prescription: Herba Cistanches 1000g, the Rhizoma Atractylodis Macrocephalae 280, Fructus Aurantii Immaturus 240g, Fructus Cannabis 240g, Radix Rehmanniae 240g
Preparation method is with embodiment 1.
The preparation three of embodiment 3 granule
Raw medicinal material prescription: Herba Cistanches 520g, Rhizoma Atractylodis Macrocephalae 520g, Fructus Aurantii Immaturus 320g, Fructus Cannabis 320g, Radix Rehmanniae 320g
Preparation method is with embodiment 1.
The preparation four of embodiment 4 granule
Raw medicinal material prescription: Herba Cistanches 700g, Rhizoma Atractylodis Macrocephalae 500g, Fructus Aurantii Immaturus 250g, Fructus Cannabis 300g, Radix Rehmanniae 250g
Preparation method is with embodiment 1.
The preparation five of embodiment 5 granule
Raw medicinal material prescription: Herba Cistanches 400g, Rhizoma Atractylodis Macrocephalae 500g, Fructus Aurantii Immaturus 300g, Fructus Cannabis 300g, Radix Rehmanniae 300g
Preparation method is with embodiment 1.
The preparation of embodiment 6 oral liquid
(1) above-mentioned gomi herbs, weighs by mass percentage, for subsequent use;
(2) get the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Fructus Cannabis, the water adding 10 times amount distills 2 hours, and collect the volatile oil in distillate, another device saves backup, and liquid filtering is for subsequent use, and medicinal residues add water 6 times and extract 1.5 hours, and filter, merging filtrate is for subsequent use;
(3) get Herba Cistanches and Radix Rehmanniae, water extraction twice, first time adds the water extraction 2 hours of 8 times amount, second time adds the water extraction 2 hours of 6 times amount, filters, merges with front step filtrate, vacuum concentration is to relative density 1.25-1.30 (60 DEG C) clear paste, for subsequent use.
(4) get above-mentioned clear paste, add the dilution of appropriate purified water, then add appropriate sodium benzoate (pharmaceutical grade food antiseptics), simple syrup (correctives), disodium edetate, dissolve, be diluted to prescribed volume by purified water, subpackage, packaging, to obtain final product.The specification of obtained oral liquid is: 10ml/ props up.Usage and dosage is: oral, a 10ml, 2 ~ 3 times on the one.
The preparation of embodiment 7 capsule
(1) above-mentioned gomi herbs, weighs by mass percentage, for subsequent use;
(2) get the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Fructus Cannabis, the water adding 10 times amount distills 2 hours, and collect the volatile oil in distillate, another device saves backup, and liquid filtering is for subsequent use, and medicinal residues add water 6 times and extract 1.5 hours, and filter, merging filtrate is for subsequent use;
(3) get Herba Cistanches and Radix Rehmanniae, water extraction twice, first time adds the water extraction 2 hours of 8 times amount, second time adds the water extraction 2 hours of 6 times amount, filters, merges with front step filtrate, vacuum concentration is to relative density 1.25-1.30 (60 DEG C) clear paste, for subsequent use.
(4) get above-mentioned clear paste, 70 DEG C of vacuum dryings, add appropriate micropowder silica gel and pulverize, then get appropriate micropowder silica gel and volatile oil mix, then get appropriate amount of auxiliary materials and always mix, incapsulate shell, subpackage, pack, both must.
The specification of obtained capsule is: 0.3g/ grain.Usage and dosage is: oral, one time 3,2 ~ 3 times on the one.
The preparation of embodiment 8 tablet
(1) above-mentioned gomi herbs, weighs by mass percentage, for subsequent use;
(2) get the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Fructus Cannabis, the water adding 10 times amount distills 2 hours, and collect the volatile oil in distillate, another device saves backup, and liquid filtering is for subsequent use, and medicinal residues add water 6 times and extract 1.5 hours, and filter, merging filtrate is for subsequent use;
(3) get Herba Cistanches and Radix Rehmanniae, water extraction twice, first time adds the water extraction 2 hours of 8 times amount, second time adds the water extraction 2 hours of 6 times amount, filters, merges with front step filtrate, vacuum concentration is to relative density 1.25-1.30 (60 DEG C) clear paste, for subsequent use.
(3) magnesium stearate is always mixed, and takes out, tabletting, subpackage, packaging, both.
The specification of obtained tablet is: 0.3g/ sheet.Usage and dosage is: oral, one time 3,2 ~ 3 times on the one.
Experimental example 1 is on the impact of diphenoxylate model mice defecating feces excretion
Get mice 72, body weight 18 ~ 22g, male and female half and half.Be divided into 6 groups at random, be respectively the high, medium and low dosage group of health product health product of the present invention, positive drug constipation relieving preparation group, model group and normal group.Each animal fasting, drinking-water 12h, gavage gives diphenoxylate suspension 25mg/kg, and normal group gives normal saline.After 0.5h, each treated animal gavage gives test medicine (adding india ink by 2% volume in medicine), administration volume is 10mL/kg (body weight), and model group and normal group give isopyknic normal saline (adding india ink by 2% volume).After administration every mice as on 1*1cm screen cloth, upper cover face diameter is the circular funnel of 10cm, 10*10lcm filter paper on screen cloth underlay.Observed and recorded often organizes mice defecation number, for the first time defecation time, fecal grains, stool weight.Continuous Observation 6h, the difference of more each treated animal These parameters, and carry out t inspection.
Result shows: the effect that the defecation frequency of health product health product of the present invention to diphenoxylate model mice is significantly increased, and can shorten the incubation period of mice defecation time, have significant difference compared with model group.The results are shown in Table 1.
Table 1: health product health product of the present invention are on the impact of diphenoxylate model mice defecation
Note: model group compares with blank group:
##p<0.01; Administration group compares with model group:
*p<0.05,
*p<0.01.
The drug action of experimental example 2 pairs of hydropenia dryness accumulated in the stomach and intestine Constipation Models
Get mice 72, body weight 18 ~ 22g, male and female half and half.Stay 12 as Normal group, conventional raising.An another 6O modeling, animal prohibits water, non-fasting 3d.There is the shrivelled slight of stature of outward appearance in modeling mice, slightly perpendicular hair, yellow urine, and be convenient to greatly knot, and become round bead shape or beading, granule is tiny, and water content obviously reduces, modeling success.Modeling success mice is divided into high, medium and low dosage group at random, positive drug group and model group, often organize 12, gavage the high, medium and low dosage of health product health product of the present invention respectively, positive drug, model group and normal group give equal-volume normal saline, and administration volume is 10mL/kg (body weight), give india ink all containing 2% in medicinal liquid and normal saline.After administration every mice as on 1*1cm screen cloth, upper cover face diameter is the circular funnel of 10cm, 10*10cm filter paper on screen cloth underlay.Record every mice and discharge defecation grain number and excrement weight in time (defecation incubation period) of melena and 6h first.
Result shows: the blank group of dryness accumulated in the stomach and intestine type model group mice compares, inquire during defecation aobvious to extend, defecation grain number obviously reduces, high, medium and low 3 dosage groups all obviously can shorten the melena time of row first of dryness accumulated in the stomach and intestine type mice with constipation, and can increase mice defecation frequency and stool weight.The results are shown in following table 2.
Table 2: on the impact of dryness accumulated in the stomach and intestine model mice defecation
Note: model group compares with blank group:
##p<0.01; Administration group compares with model group:
*p<0.05,
*p<0.01.
Experimental example 3 health product of the present invention are on the impact of isolated ileum segments in guinea pigs smooth muscle self-disciplining activity
Get Cavia porcellus (male and female are regardless of, body weight 400 ~ 500g), test before fasting can't help water 24h, with mallet fiercely attack Cavia porcellus oblongata portion cause its stupor, cut open the belly rapidly and fetch intestinal, put into immediately containing saturated mist (95%O
2+ 5%CO
2) cold tyrode's solution in, rinse well, be separated mesentery, 4 DEG C of refrigerator cold-storages are for subsequent use.During test, originally, diagonal angle, two ends threading, is placed in the bath containing 20ml tyrode's solution, ties up on the hook of breather by its lower end label taking, and upper end connects tonotransducer, continues logical mist (95%O
2+ 5%CO
2) (about 1 ~ 2 bubble/s), constant temperature (37 ± 0.5 DEG C), specimen preload 1g, balance 30min.Medlab Biological Signal Collecting System first traces one section of normal bowel smooth muscle contraction curve, treats that contraction stablizes in backward bath that to add final concentration be 1 × 10
-5the Ach of mol/L, after 1min, after observed and recorded adds each 200 μ L of blank, the high, medium and low dosage of health product of the present invention and positive drug respectively, observes in vitro intestinal smooth muscle contractile response situation.After record adds Ach in 1min and the mean tension given after health product of the present invention in 4min, and calculate suppression ratio according to average tension value.
Experimental result: after adding test medicine, of short duration relaxing first appears in isolated ileum segments in guinea pigs smooth muscle, then see that irritability increases, shrinkage amplitude increases, and tension force improves, high, medium and low dosage group compares P<0.01 with blank group, and difference has significance.The results are shown in following table 3.
The impact that table 3 health product of the present invention shrink guinea pig in vitro intestinal smooth muscle
Note: compare with blank group:
*p<0.01.
Experimental example 4 health product bowel relaxing functions of the present invention human feeding trial
Self cross-reference is adopted to carry out trial test.Select 30 routine volunteers, test-meal group experimenter presses everyone daily health product of the present invention at duration of test, takes 7d altogether.Duration of test requires that experimenter does not change original dietary habit, if there is serious untoward reaction and adverse events, stops test immediately.
1. observation index and method
1.1 general status observes the spirit, sleep, diet, defecation, blood pressure, heart rate etc. of experimenter.
1.2 blood, urine, feces are conventional, blood biochemical item inspection.
1.3 Chest X-rays, electrocardiogram, Abdominal B type ultrasonography (checking 1 time before on-test).
1.4 the defecation frequency change of 7d in 6d and test-meal before defecation frequency investigation records every day experimenter test-meal.
1.5 defecation condition investigation: according to difficult defecation degree (stomachache or anus burn feeling, bearing down, sense of discomfort, whether just frequently but difficult defecation and measure the symptoms such as few) be divided into I ~ IV grade.I grade (0 point): defecation is normal; II grade (1 point): only have bearing down, sense of discomfort; III grade (2 points): bearing down, sense of discomfort are obvious, or have just frequently but difficult defecation and measure few, less appearances is suffered from abdominal pain or anus burn feeling; IV grade (3 points): often stomachache or anus burn feeling, affects defecation.
1.6 feces character investigation: feces character is divided into I ~ III grade according to Bristol (Bristol) feces character classification method.I level (0 point): as sausage or Serpentis, level and smooth and soft; Picture sausage, but have slight crack on its surface; Soft agglomerate, has obvious edge (easily discharging); II grade (1 point): sausage shape, but have agglomerate; Loose bulk, edge roughness, as slimy feces; III grade (2 points): the hard group of separation, as pit (not easily discharging).
2. result of the test
Basic condition before 2.1 experimenter's tests.See the following form 4.
Table 4 experimenter tests front basic condition
2.2 health product of the present invention are on the impact of efficiency index
Whole experimenter all collects satisfactory data, and the expulsion rate of test is 0.From table 5, test-meal group experimenter takes health product 7d of the present invention, the defecation frequency comparatively front obviously increase of test-meal of test-meal group, the comparatively front obviously decline of test-meal of defecation condition average integral, the comparatively front obviously decline of test-meal of feces character average integral, difference all has statistical significance (P<0.01).
Table 5 the present invention is on the impact of efficiency index
Untoward reaction during 2.3 test-meals
During taking health product of the present invention, there is not the untoward reaction such as Nausea and vomiting, abdominal distention, diarrhoea, feces exception in experimenter.
2.4 changes of experimenter's dietary habit during test-meal
Plant food intake dose is rear before the test self to be compared, the equal not statistically significant of difference (P>0.05).Before test-meal, plant group food intake is 625 ± 80g/d, and after test-meal, plant food intake dose is 645 ± 100g/d.
2.5 changes of experimenter's safety index during test-meal
From table 6, experimenter test before and after routine blood test chemical examination and serum biochemistry check result all in range of normal value, in addition experimenter urine, feces routine and Chest X-rays, electrocardiogram and Abdominal B type ultrasonography result all normal.
Table 6 the present invention is on the impact of experimenter's safety index
Show that health product of the present invention have the function of loosening bowel to relieve constipation, and to the detrimental effect of experimenter's health, may be used for treatment middle-aged and elderly people constipation completely and see awareness of defecation and just secondary minimizing, defecation is difficult or defecation is not smooth, or have just matter dry and hard, abdominal distention, stomachache, weak etc.
Claims (4)
1. treat a Chinese medicine health care product for middle-aged and elderly people constipation, it is characterized in that, be made up of the raw material of Chinese medicine of following weight percentage ratio: Herba Cistanches 14 ~ 50%, the Rhizoma Atractylodis Macrocephalae 14 ~ 50%, Fructus Aurantii Immaturus 12 ~ 30%, Fructus Cannabis 12 ~ 30%, Radix Rehmanniae 12 ~ 30%, each component sum is 100%.
2. the Chinese medicine health care product for the treatment of middle-aged and elderly people according to claim 1 constipation, it is characterized in that, be made up of the raw material of Chinese medicine of following weight percentage ratio: Herba Cistanches 20 ~ 35%, the Rhizoma Atractylodis Macrocephalae 20 ~ 35%, Fructus Aurantii Immaturus 12 ~ 25%, Fructus Cannabis 12 ~ 25%, Radix Rehmanniae 12 ~ 25%, each component sum is 100%.
3. the Chinese medicine health care product for the treatment of middle-aged and elderly people according to claim 1 constipation, is characterized in that, the dosage form of described Chinese medicine health care product is one of them of granule or capsule or tablet or oral solutions.
4. prepare the method for the Chinese medicine health care product for the treatment of middle-aged and elderly people according to claim 1 constipation, it is characterized in that, comprise the following steps successively:
(1) each raw material is taken by mass percent according to claim 1;
(2) get the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Fructus Cannabis, the water adding 10 times amount distills 2 hours, and collect the volatile oil in distillate, another device saves backup, and liquid filtering is for subsequent use, and medicinal residues add water 6 times and extract 1.5 hours, and filter, merging filtrate is for subsequent use;
(3) get Herba Cistanches and Radix Rehmanniae, water extraction twice, first time adds the water extraction 2 hours of 8 times amount, and second time adds the water extraction 2 hours of 6 times amount, and filter, merge with front step filtrate, vacuum concentration is to relative density 1.25-1.30 clear paste, for subsequent use.
(4) get above-mentioned clear paste, make granule or capsule or tablet or oral solutions by Chinese patent medicine routine fashion.
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| CN112007088A (en) * | 2020-09-24 | 2020-12-01 | 上海交通大学医学院附属新华医院 | Prescription for relieving constipation symptom of Parkinson disease patient |
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