JPH04243834A - Pharmaceutical composition - Google Patents

Abstract

PURPOSE: To obtain a medicinal composition effective to a cancer, especially a leukemia, a polyp (stomach, intenstine, vocal cord, gallbladder and bile duct), a uterus cancer, an ovary cancer, a breast cancer, a urinary bladder cancer, a pancreas cancer, a hysteromyoma, a lung cancer, a rheumatoid arthritis, a neuralgia and arthritis, alleviating the symptoms of AIDS, a collagen disease, a Raynaud's syndrome, a hepatitis, a renal failure, dysfunctions of kidney, spleen pancreas and intestine, and obesity, and capable of being used effectively and safely in the body status improvement in a dermatitis, an atopic trait, an allergic trait, when removing hairs, etc., and also administered before the discharge of ascites or before the renal dialysis for the acceleration of recovery. CONSTITUTION: This agent is obtained by adding an extract of the seeds of Phyllostachys pubescans to Hoelen, maturing and drying, also adding extracts of Arecae seemen, Rhei rhizoma, Drinaria fortunel, etc., to Talcum crystalinum, mixing and drying, and adding a crushed raw Bidens pilosal var. minor and bezoar bovis dissolved in hot water consecutively and repeatedly for absorbing into the above dried powders to make a whole material as a uniform dried powder.

Description

[Detailed description of the invention]

0001

[Field of Industrial Application] The present invention is applicable to cancer, particularly leukemia, polyps (stomach, intestines, vocal cords, gallbladder, bile ducts), uterine cancer, ovarian cancer, breast cancer, bladder cancer, pancreatic cancer, uterine fibroids, lung cancer, rheumatism, Effective for neuralgia, arthritis, AIDS, collagen disease, Raynaud's symptoms,
A pharmaceutical composition that can be used effectively and safely for alleviating symptoms such as hepatitis, renal failure, decreased kidney, spleen, pancreatic, and intestinal function, and obesity, as well as for improving the constitution of dermatitis, atopic constitution, allergic constitution, and hair loss. It is also used to speed up recovery by administering it before draining ascites or before renal dialysis.

0002

[Prior art] The use of Chinese herbal medicine preparations for cancer is as post-surgery treatment to improve the general condition with Juzentaihoto or Hochuekkito, or to improve immunity even in cases where surgery is not possible. Juzentaihoto and the like are used in anticipation of this, and Shosaikoto and Ninjinto are also known to be effective, and these are often used in combination with anticancer agents such as 5-fluorouracil.

[0003] Also, steroids are often used for long periods of time in collagen disease, resulting in side effects such as ulcers and kidney damage, making it impossible to continue taking the medication. , Keishi Futakoshi Kyoichito, Shinbuto, Juzentaihoto or Bakumondoto are used, and for allergic diseases and atopic diseases, Shoseiryuto and Masan Kansekito are used depending on the symptoms. , Saiboku-yu, Mystic-yu, Bakumon-fu-yu, Goko-yu, and Daibofu-yu are also said to be effective.

However, although the above-mentioned measures are effective in some cases, they are not sufficiently effective, and do not have sufficient effects to suppress the activity of lesions or regenerate or activate atrophied tissues, and in many cases, they do not have the effect of suppressing the activity of lesions or regenerating or activating atrophied tissues. It's just a slowing effect.

[0005]

[Problem to be solved by the invention] Side effects of pharmaceuticals occur because the human body resists and exerts a defensive action when a compound that is originally foreign to humans is administered to the human body. It is difficult to predict how the human body will react to the effects of a foreign substance that has never been experienced before, and drugs have both main effects and side effects, and they vary depending on the biological situation at the time. It does not necessarily mean that the effect is the main effect or the side effect; what is convenient for the human body is the main effect, and what is not convenient for the human body is the side effect.Furthermore, there are individual differences among animals, especially humans, and statistical Even if a large number of test cases were conducted, it would still be difficult to say that there were no individuals who had a unique reaction.
This problem is especially serious when the drug is a synthetic drug.

[0006] The present invention utilizes the waste products of various familiar plants and animal foods that humans, not to mention animals on earth, have used to sustain their lives naturally since the beginning of recorded history. Although some have established their status as crude drugs,
Based on recipes handed down from ancient times using these ingredients as raw materials, we use unique processing methods based on experience to ensure the expression of effects,
By further improving this, we have established a combination of raw materials and a processing method that is extremely safe, has virtually no adverse side effects for patients, and is highly effective.

[0007]

[Means for Solving the Problems] The present invention is based on the inventor's experience of using the recipe and continuous research on the recipe that has been passed down to the inventor's family over the past 2000 years and has been improved over time. Regardless of proven or false evidence, it is often effective for a wide range of indications, even in patients who have not seen improvement with Western medical therapy, by simply adjusting the dosage. , the precision and breadth of its effects are unprecedented.

[0008] The raw materials used in the present invention are as follows: ■ Hoelen. Poria coco, a type of basidiomycete in the family Arunochidae.
The sclerotia from which most of the outer layer has been removed (S. Wolf) is dried and is traded as a herbal medicine.It is listed in the Japanese Bureau of Pharmacy No. 11 and is said to have diuretic, stomachic, and sedative effects.

[0009] ■ Hairy bamboo shoots: Also called hairy bamboo shoots, Moso bamboo shoots P.
hyllostachys pubescens
MAZEL EX H. de lehaie seedlings, also known as cat head bamboo, Jiangnan bamboo, raccoon head bamboo, and other names, and its ingredients include 0.5 mg of iron in 100 g of edible portion with 88% water content.
In addition to 10 mg of calcium, the existence of polysaccharides that have the effect of resisting Ehrlich's carcinoma and Sarcoma 180 in mice has been reported, and has been used for detoxification since ancient times [Dictionary of Chinese Medicine - Shogakukan ].

■Betel nut: Areca ca
Techu Linne seeds, which are traded as crude drugs, are usually the seeds separated from the pulp, boiled with lime water or water, and then dried, and there are also those whose seeds are separated after drying the fruit with heat. Areca nut (ARE)
It is listed as CAE SEMEN) and is said to have tapeworm exterminating and antidiarrheal effects, but in the present invention, it is used freshly matured and dried in the sun.

[0011] Talc: An important water use medicine since the Shen-Nung Bent Herbal Classics, it contains hydrated aluminum silicate, hydrated magnesium silicate, hydrated calcium silicate, and magnesium. It is produced as aggregates of fine crystals such as lumps and fibers, or plate-like or scale-like crystals, and has been used for anti-inflammatory, diuretic, antidiarrheal, cutting, etc. since ancient times, and is listed in the Japanese Pharmacopoeia Non-Herbal Medicine Standards. The substance listed as TALCUMCRYSTALLINUM is made of natural hydrous aluminum silicate and silicon dioxide, and is listed as talc (TALC) in Japanese Bureau 11.
What is listed as CUM is a natural hydrous magnesium silicate and is said to sometimes contain a small amount of aluminum silicate, but any material may be used in the present invention.

■Rhei Rhizoma, R
hubarb. Medicinal rhubarb (Rheum), a plant of the Octopus family.
official Baill), Tango special rhubarb (
Rheumtanguticum Maxim. ex
Balf). Rheum palma
tum L. ) and other rhizomes, which are traded as herbal medicines are usually dried in the shade and air-dried, and are listed in Japanese Pharmacopoeia No. 11, and are used for anti-diarrhea, stomach health, diuresis, intestinal regulation, etc.

■ Bezoar Bovis, O
riental Bezoar. Stones in the gallbladder, bile duct, and hepatic duct of bovine animals, yellow cattle (cows), and water buffaloes.It is used for the purposes of promoting erythropoiesis, sedation, antispasmodic, cardiotonic, increasing blood pressure, lowering blood pressure, antipyretic, and choleretic. It is featured on Japan Bureau 11.

■ Drinaria fortunei: Drinaria fortunei (Japanese name: Hakamauraboshi)
Kunze) J. Sm. , Chinese Drynaria
Baronii (Christ) Diels, Drynaria propinqua (Wall.
)J. Sm. , Pseudorynaria c
oronans (Wall,) Ching, Phymatodes lucida (Roxb.)
Ching, and Humata Trifoliata C
A.V. , Davallia orient
alis C. Chr. (Japanese name Taichuushinobu),
Daval (Japanese name Shinobu, Taiwanese Shinobu)
Vine-like rhizomes such as lia mariesii Moore, Polypodiu (Japanese name: Aonekazura)
The vine-shaped rhizomes of M. niponicum Mett are also used [Encyclopedia of Traditional Chinese Medicine - Shogakukan, Taiwanese Botanical Dictionary - Tennen Shosha - Taipei City, 1982]. There is also a book [Taiwanese Botanical Nomenclature - supra] that lists the Japanese names Miyamashinobu, Shimashinobu, Atsubashinobu, Alisanshinobu, Koutoshinobu, Kikushinobu, Tropical staghorn bracken, and Alisan auren fern, which has a scaly outer skin. It is said to have the effect of replenishing the kidneys, activating blood, and stopping bleeding.

■Bidens pilosa L.var.min: Asteraceae plant Bidens pilosa L.var.min
Or (Bl.) Sherff), the whole plant is usually used, but those with yellow flowers can be used although the effect is weak,
viflora Will, also known as staghorn grass and prickly grass)
, Kinsan Kinbang (Kinshi Ginban)
dens pilosa or Binde
ns biternata (Lour.) Merr.
et Sherff] is also used [Encyclopedia of Chinese Medicine - Shogakukan, Primary Color Makino Encyclopedia of Japanese and Chinese Herbs - Hokuryukan], analgesic, diuretic,
It is used for detoxification and anti-inflammatory purposes, but in the present invention, it is preferable to use only its new shoots and young leaves. .

[0016] First, let's talk about Bukryo (Bukryo).
We have discovered cases where gastric cancer, uterine cancer, colorectal cancer, and other cancers disappeared by treatment with the drug used by the inventor or by natural recovery. After a detailed investigation of the patients' eating habits, it was discovered that these patients regularly consumed bamboo shoot soup, and that they regularly consumed bamboo shoots without throwing away the broth.

[0017] Bukryo (Bukryo) widely used in Chinese medicine
The bamboo shoots are usually dried in the shade and stored in a cool, dark place, and care must be taken to prevent them from cracking, losing viscosity, or becoming too dry. Although it is possible that the presence of the boiled juice of Mōjung modifies the change in its components during autolysis of Bukryō, the active ingredients in the boiled water of Mōjung (hairy bamboo shoot) may be modified by the action of the enzyme of Bukryō In particular, anticancer/anticancer ingredients and their effects are thought to be enhanced.

As a result, the composition of the present invention purifies cell membranes and strengthens the complement of the immune system, further increasing its efficacy, and has shown remarkable effects on leukemia, uterine cancer, polyp, breast cancer, etc. In fact, there are cases where even breast cancer that had metastasized to the pelvis was completely cured and new bone tissue was generated.

[0019] Areca nut and rhubarb
Even in the process of heating and extracting with water together with Zuihou (or you can extract it separately and mix it while it is hot), the enzyme action may work on each other's components while processing a large amount of raw materials. It is expected that as the enzymes are deactivated by heating, the mutual reactions will shift to chemical reactions and result in a complex composition of components, which will promote the excretion of cancer and tumor toxins,
It suppresses the division of cancer cells and promotes the normal functioning of bone marrow buds. It also suppresses pain accurately.

Furthermore, according to the present invention, by distributing Chillinga japonica, we have been able to promote cell respiration and increase the supply of oxygen, thereby successfully alleviating the pain of even terminal cancer patients.

[0021] This will be explained in more detail with reference to the following examples. Example 1: 40 kg of Bukryo was cut into small pieces, and a liquid obtained by boiling 20 kg of Moujun (hairy bamboo shoots) in 100 liters of water for 2 hours was added thereto, and the mixture was heated at about 37°C. The product that is aged for a whole day and night, evaporated in the sun, dried and powdered is called A, and betel nut 2
5 kg of rhubarb, 5 kg of rhubarb, and 5 kg of zuiho were chopped and boiled in 50 liters of water for 2 hours.The liquid was concentrated to about half, while 1 kg of talc
The filtrate was added to 5 kg (roasted slowly on a wire mesh beforehand and then turned into powder), and the thick liquid became B, and B was added little by little to A and dried in the sun repeatedly. C was made into a powder, and D was made into a dry powder by repeating the process of crushing 10 kg of new shoots of Ganfuusou (wind-containing grass), mixing it with C, and drying it.
Then, repeat the operation of dissolving 10 kg of gouhou powder in 200 liters of boiling water, absorbing it in D, and drying it, and make the whole into a uniform powder to obtain the desired pharmaceutical composition 5.
0 kg was obtained, and the general analysis values of this product are as follows.

[0022] Moisture Protein Lipid Fiber Ash
Carbohydrate 1.9% 1.0% 0.
3% 2.8% 83.3% 10.7
%

Example 2: 50 kg of Bukryo
Finely chop 25 kg of betel nut, boil it in 125 liters of water for 2 hours, add the liquid, age at about 37°C for a whole day and night, evaporate it in the sun, dry it, and turn it into powder. Meanwhile, 31 kg of betel nut , 6 kg of rhubarb, and 6 kg of zuiho were chopped, 62 liters of water was added to them, and the mixture was decocted for 2 hours. The liquid was concentrated to about half, and the mixture was slowly roasted on a wire mesh to make powdered kasseki. Add the filtrate to 19 kg of talc, dry in the sun, mix both powders, mix with 13 kg of ground buds of Ganfuusou, and dry. Repeat this process to obtain a dry powder.
The process of absorbing 8 kg of powdered gourd (beef yellow) dissolved in 1 liter of water and drying it was repeated to make a uniform dry powder of 8 kg.
2 kg of the target pharmaceutical composition was obtained, and the general analytical values of this product were as follows.

[0024] Moisture Protein Lipid Fiber Ash
Carbohydrate 5.0% 2.0% 0.
4% 4.5% 70.0% 18.1
%

[0025]

[Usage] Immediately after starting administration of the obtained pharmaceutical composition, side effects such as redness, eczema, and itching may be observed due to the immunogenic reaction, but this is considered to be a phenomenon of expelling toxins from the body and evidence of improvement. The dosage is 1 to 4 g at a time depending on the symptoms, usually 3 g is taken orally at first, 3 to 4 times a day, and then gradually reduced while monitoring the progress to once a day to maintain the effect of improving the constitution. do it like this.

[0026] In people who used the composition of the present invention for a long period of time, it was observed that the contours of the bones became clearer in X-ray photographs, supporting that bone metabolism was promoted and bone regeneration was activated. It has also been observed that the skin on the soles of the feet, which has become keratinized, becomes fresher and fresher.

Test Example 1: Chiu○○, a 60-year-old female, had severe edema due to chronic hepatitis, but after administering 12 g/day of the composition obtained in Example 1 for 4 months, she made a complete recovery and has been in good health since then.

Test Example 2: King XXX, 36-year-old male, hepatitis B,
When 8 g/day of the composition obtained in Example 2 was administered, the patient made a complete recovery 6 months later and has been in good health since then.

Test Example 3: Lu○○, 23-year-old male, chronic hepatitis,
The patient suffered from gastrointestinal weakness and neck stiffness. When 8 g/day of the composition obtained in Example 1 was administered, the patient completely recovered in 4 months and has been in good health since then.

Test Example 4: Cai○○, 30-year-old male, diagnosed with lung cancer at another hospital, X-rays showed scattered black spots in the lungs, 12 g/day of the composition obtained in Example 2, 6 g/day from 3 months later. After a total of 5 months of administration, the patient made a complete recovery and has been in good health ever since.

Test Example 5: Satoshi Matsu, a 65-year-old man, was diagnosed with myeloma due to immunodeficiency and leukopenia caused by pneumonia, and his white blood cell count had dropped to 1700 at the time.He underwent medical treatment. When the patient received 2g x 3/day of the composition obtained in Example 1 while undergoing treatment, the white blood cell count recovered to about 5,300 in 10 months, and no symptoms that appeared to be side effects were observed.

Test Example 6: ○Ki○ko, 28-year-old female, suffered from changes in her physical condition due to a strained back, and was repeatedly transferred to hospitals due to menstrual pain, irregular menstruation, anemia, lower back pain, autonomic nerve imbalance, etc., but she made a steady recovery. Instead, the patient continued to see an internal medicine doctor while administering 2 g x 2/day of the composition obtained in Example 2. After 5 months, the patient's complaints had almost disappeared with only mild menstrual pain remaining.

Test Example 7: Mori, 72-year-old female, diagnosed with collagen disease due to erythema on hands and arms, joint pain in hands and feet, inability to raise right arm, and difficulty walking. Composition obtained in Example 1. 2g x 1/day was administered for 3 months, but no improvement was observed, so 2g of the same composition was enriched with 0.1g of ox yolk and administered three times a day. Erythema and arthralgia disappeared within 4 months. A year later, he was able to walk without a cane.

Test Example 8: ○da ○zo, 54-year-old male, developed rheumatic symptoms due to swelling of right finger joints, positive for rheumatoid antibodies.
Arthralgia, progressive difficulty in raising both arms, and 1 year later, whole body joint stiffness.
Due to swelling and difficulty walking, I reduced my weight from 92 kg before the onset of the disease to 70 kg through abstinence.While avoiding steroids and receiving treatment in the hospital, I received 2 g of the composition obtained in Example 2 x 4/
When the drug was administered on an empty stomach, 1 week later, black stool was excreted, and 2 weeks later, swelling of the joints and temporary exacerbation of pain were observed, but the symptoms gradually improved, and the blood sedimentation level, which was 120, decreased to 70 within 3 months. Within nine months, the temperature had dropped to 30, and walking function had recovered, and other symptoms and various clinical test values had also significantly improved.

Test Example 9: Azumako, a 47-year-old female, who developed sciatica-like symptoms due to metastasis to the pelvis and had difficulty walking more than one year after breast cancer was removed. The composition obtained in Example 1. 2gX
After administering 3/day, slight improvement was observed after 1 month.
The patient was able to walk within 4 months, and all pain and other symptoms disappeared. After the discovery of metastatic cancer, this patient received no treatment other than taking this drug.

Test Example 10: Ideko, a 13-year-old female, had leukemia with a white blood cell count of 140,000 and a red blood cell count of 2,000,000, and had severe hair loss due to administration of anticancer drugs. Obtained in Example 2 while undergoing hospital treatment. When 1.5g x 3/day of the composition was administered on an empty stomach, an increase in red blood cells was observed from the 3rd month, a decrease in white blood cells and recovery of hair from the 6th month, and the values returned to normal after 2 years. Prognosis: 3 years. The patient was continuously administered 2 g x 1/day and observed, but as his health condition stabilized, the medication was discontinued.

Test Example 11: Fukuko, a 64-year-old female, had unremovable terminal uterine cancer. Her red and white blood cells were significantly reduced. Due to anticancer drugs, she was hairless and was waiting at home to die.
When 2 g of the composition obtained in Example 1 was administered 4 times a day, gradual improvement was observed, with pain being reduced and local bleeding reduced. The dose was reduced to 2 g x 3/day after 1 year, 2 g x 2/day after 2 years, and 2 g x 1/day as a maintenance dose after 3 years, but both red and white blood cell values have returned to normal. During this time, no other treatment was received. .

Test Example 12: Mr. Tsuka, 56 years old, liver cancer with a diameter of about 4 cm was discovered by ultrasonic diagnosis. When 2 g of the composition obtained in Example 2 was administered 4 times a day on an empty stomach, liver cancer was detected in 8 months. The image disappeared, and no other drugs were administered during this time.

Test Example 13: Izumi○ichi, a 63-year-old man, was visited by an orthopedic clinic because he was unable to sit upright or crouch due to serous fluid buildup in his right knee joint.The only treatment he received was to drain the water and apply a compress, but within 2 months 20
Even after draining 27 ml of water four times, the pain did not improve and the pain was so bad that she had to avoid stairs when walking.This treatment was stopped and 1 g of the composition obtained in Example 1 was administered per day for one month. The pain almost disappeared, the serous fluid did not accumulate, and I was able to sit upright and crouch.

Claims (4)

[Claims] Claim 1: Add extract of Moujun (hairy bamboo shoots) to Bukuryo, mature and dry, and extract betel nut, rhubarb, and zuihou to kasseki (talc). Add the liquid, mix and dry, and then repeatedly absorb and dry crushed raw Ganfuusou (wind-containing grass) and Gooh (ox yellow) dissolved in boiling water to these dry powders,
A pharmaceutical composition characterized in that the entire composition is a uniform dry powder. 2. The pharmaceutical composition according to claim 1, wherein the talc is roasted. 3. The pharmaceutical composition according to claim 1, wherein the Gouou (Cow yellow) is powdered after being gradually heated in advance to sufficiently remove exuded oil. 4. The pharmaceutical composition according to claim 1, wherein the herbaceous plant is a new sprout.