CN107115493A - It is a kind of to treat Chinese medicine composition of fracture and its production and use - Google Patents
It is a kind of to treat Chinese medicine composition of fracture and its production and use Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating fracture and its production and use, the Chinese medicine composition is made up of the bulk drug of following parts by weight：30-90 parts of pseudo-ginseng, 60-120 parts of levisticum, 5-20 parts of dragon's blood, 50-110 parts of myrrh, 120-180 parts of Radix Angelicae Sinensis, 5-20 parts of prepared nux vomica, 250-350 parts of muskmelon seed, 60-120 parts of ground bettle, 60-120 parts of safflower, 60-120 parts of cassia twig, 50-110 parts of frankincense, 30-70 parts of Ligusticum wallichii, 50-110 parts of earthworm, 30-90 parts of root tuber of aromatic turmeric, 150-250 parts of the rhizome of davallia, 80-160 parts of teasel root, 60-120 parts of native copper, 30-70 parts of the root of Dahurain angelica.By aforementioned proportion bulk drug crushed after being dried, traditional oral preparation is made in ultraviolet radiation sterilization processing.The present invention can be used for treating various types of fracture, the features such as with short treating period, instant effect, good effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for treating fracture and its preparation
Method and purposes.
Background technology
Fracture refers to that the cortex of bone of skeleton or the continuity integrality of bone trabecula occur in that interruption.It is clinical
Show as local swelling, deformity, tenderness, lay one's hand on and bony crepitus, pseudarthrosis formation, function lose.Fracture is not
By usually or motion when can all occur.The reason for fracture, can be divided into the traumatic and major class of pathologic two.Wound
Property fracture more as caused by direct violence and indirect violence, the former such as explosion injury, crush injury, get injured by a fall, the latter
Place hands on floor of such as falling can produce colles' fracture, supracondylar fracture of humerus, fracture of surgical neck of humerus, pathology
Fracture refers to that skeleton is ill in itself, and fracture is caused in the case of normal or slight wound.Traumatic fracture again can basis
Whether fracture communicates with the external world, and is divided into closed and open two major class.In addition, degree from violence,
The shape and fracture end of fracture, which whether there is, to be staggered or shifts.Also can be divided into completely and incomplete fracture or horizontal stroke, it is oblique,
Crushing, spiral, fracture is inlayed, there is displacement or the fracture without displacement.Treatment for fracture routinely uses hand
Art is treated and drug therapy, and drug therapy is typically frustrated using Dieda Wan, bone healing medicine, preparing, bone setting tablet, fracture
Hinder the medicines such as capsule and Qili San, although these medicines have certain curative effect to treatment fracture, but in clinic its
Effect is not it is obvious that some medicines to patient or have side effect.
Application number " 200910017891.0 " discloses pharmaceutical composition pseudo-ginseng, dragon's blood, frankincense, myrrh, Tibetan
Safflower, muskmelon seed, deer horn glue, the rhizome of davallia, native copper, ground bettle, snake bubble gold, salt efflorescence cypress, refute greatly bone,
Teasel root, Moschus etc. are used to treat fracture effect significantly, but contain safflower, deer horn glue and Moschus etc. in the medicine
Rare medicinal herbs, and large usage quantity, production cost are too high, are not suitable for industrialization.
The content of the invention
In order to solve the above-mentioned technical problem, it is an object of the invention to provide a kind of Chinese medicine composition for treating fracture
And its production and use.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Chinese medicine composition for treating fracture of the present invention, the Chinese medicine composition is by following parts by weight
The bulk drug composition of proportioning：30-90 parts of pseudo-ginseng, 60-120 parts of levisticum, 5-20 parts of dragon's blood, myrrh 50-110
Part, 120-180 parts of Radix Angelicae Sinensis, 5-20 parts of prepared nux vomica, 250-350 parts of muskmelon seed, 60-120 parts of ground bettle,
60-120 parts of safflower, 60-120 parts of cassia twig, 50-110 parts of frankincense, 30-70 parts of Ligusticum wallichii, earthworm 50-110
Part, 30-90 parts of root tuber of aromatic turmeric, 150-250 parts of the rhizome of davallia, 80-160 parts of teasel root, 60-120 parts of native copper, in vain
30-70 parts of the root of Dahurian angelica.
It is further preferred that the Chinese medicine composition is made up of the bulk drug of following weight：Pseudo-ginseng
50-70 parts, 80-100 parts of levisticum, 8-12 parts of dragon's blood, 70-90 parts of myrrh, 140-160 parts of Radix Angelicae Sinensis, Strychnos nux-vomica
Sub- powder 8-12 parts, 280-320 parts of muskmelon seed, 80-100 parts of ground bettle, 80-100 parts of safflower, cassia twig 80-100
Part, 70-90 parts of frankincense, 40-60 parts of Ligusticum wallichii, 70-90 parts of earthworm, 50-70 parts of root tuber of aromatic turmeric, rhizome of davallia 180-220
Part, 100-140 parts of teasel root, 80-100 parts of native copper, 40-60 parts of the root of Dahurain angelica.
Further preferably, the Chinese medicine composition is made up of the bulk drug of following weight：Pseudo-ginseng
60 parts, 90 parts of levisticum, 10 parts of dragon's blood, 80 parts of myrrh, 150 parts of Radix Angelicae Sinensis, 10 parts of prepared nux vomica, sweet tea
300 parts of melon seeds, 90 parts of ground bettle, 90 parts of safflower, 90 parts of cassia twig, 80 parts of frankincense, 50 parts of Ligusticum wallichii,
80 parts of earthworm, 60 parts of root tuber of aromatic turmeric, 200 parts of the rhizome of davallia, 120 parts of teasel root, 90 parts of native copper, the root of Dahurain angelica 50
Part.
A kind of Chinese medicine composition for treating fracture described above is the various routines for containing or not contain pharmaceutic adjuvant
Extract oral medicine dosage form.
Further preferably, it is described above treatment fracture Chinese medicine composition, its preparation be powder, tablet,
Granula, capsule or pill.
The method that the present invention provides the Chinese medicine preparation for preparing above-mentioned treatment fracture, it is specific as follows：Take each parts by weight
The bulk drug of proportioning, dry, pulverize, and granularity is 80-120 mesh, after being handled through ultraviolet radiation sterilization, is pressed
The preparation process shaping of more solito.
The present invention according to China traditional Chinese medicine compatibility theory, using pseudo-ginseng, levisticum, dragon's blood, myrrh, Radix Angelicae Sinensis,
Prepared nux vomica, muskmelon seed, ground bettle, safflower, cassia twig, frankincense, Ligusticum wallichii, earthworm, root tuber of aromatic turmeric, the rhizome of davallia,
The medicament that teasel root, native copper, the root of Dahurain angelica are collectively constituted.
Pseudo-ginseng, sweet, slight bitter, temperature.Return liver, stomach.Dissipate stasis of blood hemostasis, detumescence ding-tong.For spitting blood, tell
Blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
Levisticum, pungent, hardship, tepor.Return kidney, bladder warp.Dispelling wind and eliminating dampness, numbness relieving and pain relieving.It is wet for chill
Numbness, lumbocrural pain, few the moon volt wind headache, chill holds wet headache under the arm.
Dragon's blood, it is sweet, salty, put down.The thoughts of returning home, Liver Channel.Promoting blood circulation analgesic therapy, removing blood stasis and hemostasis, myogenic sore.For
Traumatic injury, trusted subordinate's stasis caused pain, traumatism and bleeding, sore is not held back.
Myrrh, pungent, hardship is mild-natured.The thoughts of returning home, liver, the spleen channel.Scattered stasis pain, detumescence and promoting granulation.For chest
Numbness is pained, gastral cavity pain, dysmenorrhoea Amenorrhea postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, traumatic injury,
Carbuncle swells sore.
Radix Angelicae Sinensis, sweet, acrid, warm.Return liver, the heart, the spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving relaxes bowel.
For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, arthralgia pain due to rheumatism falls and flutterred
Damage, ulcer sores, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism falls
Damage is flutterred to put in order.
Prepared nux vomica, bitter, temperature；It is very toxic.Return liver, the spleen channel.Remove obstruction in channels to relieve pain, mass dissipating and swelling eliminating.For falling
Damage is played, fracture swells and ache, rheumatoid arthritis stubborn, paralysis and numbness, skin sore, abscess of throat.
Muskmelon seed, it is sweet, tremble with fear.Return lung, stomach, large intestine channel.Clearing lung-heat, ease constipation, stagnation resolvation, apocenosis is cured the wound only
Bitterly.For cough with lung heat, constipation, lung carbuncle, acute appendicitis, traumatic injury, injured bone.
Ground bettle, it is salty, tremble with fear；It is slightly poisonous.Return liver warp.Dissipating blood stasis with potent drugs, reunion of fractured tendons and bones.For traumatic injury,
Injury of tendon and muscle fracture, blood stasis, postpartum stasis stomachache , abdominal lump of mass in abdomen.
Safflower, pungent, temperature.The thoughts of returning home, Liver Channel.Invigorate blood circulation, blood stasis removing analgesic.For Amenorrhea, dysmenorrhoea is disliked
Reveal not all right , abdominal lump of mass in abdomen, chest impediment and cardialgia, stasis of blood, chest side of body is twinged, injury from falling down, sore swell and ache curative.
Cassia twig, acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi,
Flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, the heart
Throb with fear, run quickly globefish.
Frankincense, pungent, hardship, temperature.The thoughts of returning home, liver, the spleen channel.Promoting blood circulation analgesic therapy, detumescence and promoting granulation.For the obstruction of qi in the chest heart
Bitterly, gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, muscle arteries and veins contraction, bruise
Damage, carbuncle swells sore.
Ligusticum wallichii, pungent, temperature.Return liver, courage, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For chest impediment and cardialgia,
Chest side of body shouting pain, tumbling and swelling, irregular menstruation, closed dysmenorrhea , Disorder lump in the abdomen is suffered from abdominal pain, headache, arthralgia pain due to rheumatism.
Earthworm, it is salty, tremble with fear.Return liver, spleen, bladder warp.Heat-clearing is calmed the frightened, and dredging collateral is relievingd asthma, diuresis.For
Unconsciousness due to high fever, twitch, joint pain, extremity numbness, hemiplegia, dyspnea and cough due to lung-heat, oedema oliguria.
Research shows：Earthworm extract solution has good anticoagulation in vitro, can make the clotting time of blood, blood coagulation
Enzyme time, prothrombin time significantly extend, and in obvious dose-effect relationship；Blood viscosity can be reduced, is pressed down
Thrombosis processed.Its anticoagulant mechanism is that it has direct inhibitory action to thrombin-fibrinogen reaction.
Earthworm still has fibrinolysis activity, can make established thrombolysis.
Root tuber of aromatic turmeric, pungent, hardship is trembled with fear.Return liver, the heart, lung channel.Promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clear away heart-fire cool blood,
Normalizing gallbladder to cure jaundice.For chest side of body shouting pain, chest impediment and cardialgia, closed dysmenorrhea, swollen breasts, pyreticosis coma, epilepsy
Go mad, blood-head tells nosebleed, jaundice.Mainly contain and grind the compositions such as volatile oil tired zingiberene, root tuber of aromatic turmeric alkene.Research
Show, its fat injection that volatilizees can strengthen fibrinolytic, and substantially suppress blood by improving cAMP contents
Platelet is assembled, thus can play anticoagulant effect.
The rhizome of davallia, bitter, temperature.Return liver and kidney channel.Cure the wound analgesic, The strong bone of kidney tonifying；External application disappears wind nti-freckle.With
In falling winks frustrates, injured bone, lumbago due to the kidney deficiency, muscles and bones impotence, Hiccough and deaf, tooth mobility；Control spot outside
It is bald, leucoderma.
Teasel root, bitter, pungent, tepor.Return liver and kidney channel.Filling liver kidney, strengthening the bones and muscles continues injured, only uterine bleeding.
For kidney deficiency and liver, soreness and weakness of waist and knees, arthralgia pain due to rheumatism, injury from falling down, injury of tendon and muscle fracture, uterine bleeding, threatened abortion.Wine
Teasel root is used for arthralgia pain due to rheumatism, injury from falling down, injury of tendon and muscle fracture.Prepared RADIX DIPSACI with salt solution is used for soreness and weakness of waist and knees.
Native copper, it is pungent；It is flat.Return liver warp.Blood stasis removing analgesic, reunion of fractured tendons and bones.For traumatic injury, muscles and bones folding
Wound, pain caused by ecchymoma.
The root of Dahurain angelica, pungent, temperature.Return stomach, large intestine, lung channel.Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping declares clearing the nasal passage, dry
Wet stop-band, detumescence and apocenosis.For cold headache, pain in the supra-orbital bone, runny nose of having a stuffy nose, allergic rhinitis, nasosinusitis is had a toothache,
Under band, sore swell and ache curative.
According to theory of traditional Chinese medical science, fracture and injury qi and blood causes blood vessels from through absurd row, extravesated blood is detained, forms blood stasis,
So that QI-blood circulation is not normal, stasis of blood product does not dissipate, and is pain to swell.《Plain Questions writings left behind by the deceased acupuncture manipulation is discussed》In have that " healthy tendency is deposited
Interior, heresy can not be done ", using muskmelon seed, the rhizome of davallia, Radix Angelicae Sinensis and teasel root as monarch drug in a prescription in side, with the gas that makes corrections.Wherein
Radix Angelicae Sinensis blood circulation promoting and enriching；Muskmelon seed stagnation resolvation apocenosis, analgesic of curing the wound；The rhizome of davallia and teasel root are reunion of fractured tendons and bones medicine,
Wherein rhizome of davallia kidney tonifying, synthetism, and the bone wind curative effect that can dispel, are cured mainly in bone, teasel root filling liver kidney, and can relaxing muscles and tendons
It is active, cure mainly in muscle, two medicine phases 5 have the curative effect of reunion of bone.
《Dialectical record synthetism door》Point out：" the method inside controlled, it is necessary to using promoting blood circulation as first.The blood then stasis of blood not living
Can not go, the stasis of blood do not go then bone can not connect." frankincense in side, myrrh, earthworm, native copper, ground bettle, red
Flower is ministerial drug, wherein ground bettle dissipating blood stasis with potent drugs, and native copper dissipates blood and relieving pain, the blood circulation and removing stasis of two medicine phases 5, frankincense
Myrrh mutual reinforcement between to use, can myogenic promoting blood circulation, the analgesic of sharp gas, stimulate the circulation of the blood and cause the muscles and joints to relax.Earthworm is with clearing and activating the channels and collaterals, safflower work
Blood is stimulated the menstrual flow, blood stasis removing analgesic, and the effect of blood circulation and removing stasis is played altogether.
Pseudo-ginseng, dragon's blood, prepared nux vomica, the root of Dahurain angelica, root tuber of aromatic turmeric, levisticum, cassia twig are adjutant, wherein pseudo-ginseng in side
Dissipate stasis of blood hemostasis, vomiting nut activating collaterals and eliminating stagnation, cassia twig warming meridian, root tuber of aromatic turmeric and dragon's blood energy blood-activating and qi-promoting, the root of Dahurain angelica and
Levisticum wind-damp dispelling, plays blood circulation and channel invigorating, effect of scattered stasis.
Ligusticum wallichii, pungent-warm perfume (or spice) is dry, and pungent-warm, which rises, to be dissipated, and the up head, the descending sea of blood, middle relieving stagnation bypasses channels and collaterals,
It is our guiding drug for gas medicine in blood.
Full side is taken a broad view of, the present invention is taken so that tonification and purgation in combination, and the principle of reatment that healthy tendency is attached most importance to, all medicine compatibilities are precise and appropriate,
Using replenishing and activating blood, reunion of bone medicine as main ingredient, it is aided with blood circulation and removing stasis, promoting the circulation of qi is promoted blood circulation, the medicine of dissipate stasis of blood hemostasis,
Compatibility medicine for rheumatism effect, along with gas medicine Ligusticum wallichii in blood, plays replenishing and activating blood, strengthening the muscles and bones is living altogether simultaneously
Blood is by the stasis of blood, effect that promoting the circulation of qi is promoted blood circulation.Suitable for treatment all ages and classes, different parts, different types of fracture,
Effect highly significant, surpasses the commercially available Chinese patent drug of similar such as Dieda Wan, Gu Yu Ling Capsules.
With prescription very close to conventional Chinese patent drug Dieda Wan and Gu Yu Ling Capsules compared with, the present invention in reuse bone it is broken
Mend and teasel root, can strengthening the muscles and bones, reuse Radix Angelicae Sinensis, replenishing and activating blood, with the gas that makes corrections.Then heresy can be attacked healthy tendency foot,
Ground bettle, native copper large usage quantity in side, the powder medicine (Zhuyusan) blood efficacy of a drug are stronger, and add cassia twig in prescription with temperature
Qualcomm meridian, earthworm is with clearing and activating the channels and collaterals, and root tuber of aromatic turmeric can be increased medicine and be dissipated stasis of blood effect with blood-activating and qi-promoting.Guiding drug Ligusticum wallichii,
Its pungent-warm perfume (or spice) is dry, and pungent-warm, which rises, to be dissipated, and the up head, the descending sea of blood, middle relieving stagnation bypasses channels and collaterals, can made all
The medicine efficacy of a drug is given full play to.And Dieda Wan and Gu Yu Ling Capsules drug prescription compatibility reuse pseudo-ginseng and dragon's blood with
Promoting blood circulation and removing obstruction in channels, but reunion of bone, the power for dissipating the stasis of blood is weaker, and the effect of slowly effect and treatment fracture is not as good as the present invention
Significantly.
Beneficial effects of the present invention：
(1) inventive formulation is reasonable in design, and compatibility is rigorous, is verified through Long-term clinical, more similar such as Dieda Wan,
The commercially available Chinese patent drug such as bone healing medicine, preparing, the features such as with short treating period, instant effect, good effect, and toxic side effect is small,
Without any dependence.
(2) bulk drug used in the present invention is common Chinese medicine material, and convenient material drawing, technique is simple, economical real
With, it is cheap, suitable for industrialization.
Embodiment
The present invention is described in further details below by example, these examples are only used for illustrating the present invention,
It does not limit the scope of the invention.
The powder of the present invention of embodiment 1
By weight, pseudo-ginseng 90g, levisticum 120g, dragon's blood 20g, myrrh 110g, Radix Angelicae Sinensis 180g are weighed,
Prepared nux vomica 20g, muskmelon seed 350g, ground bettle 120g, safflower 120g, cassia twig 60g, frankincense 50g,
Ligusticum wallichii 30g, earthworm 50g, root tuber of aromatic turmeric 30g, rhizome of davallia 150g, teasel root 80g, native copper 60g, root of Dahurain angelica 30g
Mix drying, crush, granularity be 80-120 mesh, ultraviolet radiation sterilization handle 30 minutes, reach dry,
After loose, well mixed, color and luster is consistent, powder is made in divided dose, packaging.
The Tablets of embodiment 2
By weight, pseudo-ginseng 30g, levisticum 60g, dragon's blood 5g, myrrh 50g, Radix Angelicae Sinensis 120g, horse are weighed
Money powder 5g, muskmelon seed 250g, ground bettle 60g, safflower 60g, cassia twig 120g, frankincense 110g, Ligusticum wallichii
70g, earthworm 110g, root tuber of aromatic turmeric 90g, rhizome of davallia 250g, teasel root 160g, native copper 120g, root of Dahurain angelica 70g
Drying is mixed, is crushed, granularity is 80-120 mesh, ultraviolet radiation sterilization is handled 30 minutes, routinely preparation
Tablet is made in technique, addition appropriate amount of auxiliary materials.
The granule of the present invention of embodiment 3
By weight, pseudo-ginseng 50g, levisticum 80g, dragon's blood 8g, myrrh 70g, Radix Angelicae Sinensis 140g, horse are weighed
Money powder 8g, muskmelon seed 280g, ground bettle 80g, safflower 80g, cassia twig 100g, frankincense 90g, Ligusticum wallichii
60g, earthworm 90g, root tuber of aromatic turmeric 70g, rhizome of davallia 220g, teasel root 140g, native copper 100g, root of Dahurain angelica 60g are mixed
Even drying, is crushed, and granularity is 80-120 mesh, and ultraviolet radiation sterilization is handled 30 minutes, routinely preparation work
Granule is made in skill, addition appropriate amount of auxiliary materials.
The capsule of the present invention of embodiment 4
By weight, pseudo-ginseng 70g, levisticum 100g, dragon's blood 12g, myrrh 90g, Radix Angelicae Sinensis 160g are weighed,
Prepared nux vomica 12g, muskmelon seed 320g, ground bettle 100g, safflower 100g, cassia twig 80g, frankincense 70g,
Ligusticum wallichii 40g, earthworm 70g, root tuber of aromatic turmeric 50g, rhizome of davallia 180g, teasel root 100g, native copper 80g, root of Dahurain angelica 40g
Drying is mixed, is crushed, granularity is 80-120 mesh, ultraviolet radiation sterilization is handled 30 minutes, routinely preparation
Capsule is made in technique, addition appropriate amount of auxiliary materials
The pill of the present invention of embodiment 5
By weight, pseudo-ginseng 60g, levisticum 90g, dragon's blood 10g, myrrh 80g, Radix Angelicae Sinensis 150g are weighed,
Prepared nux vomica 10g, muskmelon seed 300g, ground bettle 90g, safflower 90g, cassia twig 90g, frankincense 80g, river
Rhizome of chuanxiong 50g, earthworm 80g, root tuber of aromatic turmeric 60g, rhizome of davallia 200g, teasel root 120g, native copper 90g, root of Dahurain angelica 50g
Drying is mixed, is crushed, granularity is 80-120 mesh, ultraviolet radiation sterilization is handled 30 minutes, routinely preparation
Pill is made in technique, addition appropriate amount of auxiliary materials.
First, pharmacological toxicity is tested
1. endo-medicine cumulative toxicity test
By taking the pill of the embodiment of the present invention 5 as an example, endo-medicine cumulative toxicity test is carried out.From 20 health
Small white mouse, female, male each 10, every 5 days of dose design is a phase, and each issue of dosage is respectively 0.10LD50、
0.15LD50、0.22LD50、0.34LD50、0.50LD50, the female of this sample, the LD of male mice50
For 6500m parts/k parts BW (five dosage are 650,975,1430,2210,3250m parts/k parts BW).
Weigh once within every 5 days, dosage is adjusted, by the 0.15ml/10 parts of oral gavages of BW.After 20 days, move
Thing without death condition occur, off-test, by ascending-dose to tested material 20 days after, female, buck
Occur without death condition.
2. acute toxicity test
By taking the pill of the embodiment of the present invention 5 as an example, acute experiment is carried out.Medicine is pressed the 200 of clinical consumption per day
Give white mouse oral gavage dispensing again, observe 5.As a result all animals are strong deposits, its activity, diet, hair,
Excreta is no abnormal, has no toxic reaction.
3. long term toxicity test
By taking the pill of the embodiment of the present invention 5 as an example, long term toxicity test is carried out.Administration time is the 2 of clinical course for the treatment of
More than times, by clinical consumption per day 2.8g/kg (50 times), 1.7g/kg (30 times), 0.8g/kg (15 times) agent in three months
Amount has carried out 60 days gastric infusions of big white mouse, while setting negative control group (water).Daily gavage once, continuously
6 times, interval one day observes administration group and control rats diet, the general status such as hair color and activity, every two
Week claims a body weight, to adjust dosage.Each group puts to death 12 rats on an empty stomach after last gives 24 hours,
Blood is taken to carry out hematology 5 and coagulation time test；Separate serum and carry out 10 Biochemical Indexes and 13
Item internal organs are weighed, and calculate dirty body ratio, and each internal organs makees histopathological examination.Remaining every group of 8 rat stops
Only it is administered, observation is handled in the same fashion after 2 weeks, checks above-mentioned indices.It is statistically analyzed, gives
Each dosage of medicine group is compared with negative control group, difference that there are no significant substantially.The result card of above-mentioned indices
Real, the observation of tablet of the invention through rat continuous gavage 2 months and after being discontinued 2 weeks has no obvious poison
Property reaction.
2nd, evaluation of the Chinese medicine composition of the present invention to treatment fracture
In order to verify the therapeutic effect of Chinese medicine composition of the present invention, spy of the present invention has carried out following comparative study.
1st, the standard of case is selected
Fracture patient caused by all a variety of causes is the standard for selecting case, completely bone necrosis and loss nothing
Method is connect except limb or regeneration, does not limit the age.
2nd, diagnostic criteria
The injury of skeleton caused by various external force, including bone is disconnected, ostealleosis, bone are crushed etc. and has X-ray
Determined, be diagnosed as fracture.
3rd, therapeutic scheme
400 fracture patients for meeting above-mentioned diagnostic criteria are grouped at random, be divided into three control groups and
One experimental group, is treated in accordance with the following methods respectively.
Control group 1：Take Dieda Wan, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory's production.Mouthful
Clothes, 1 ball, 2 times a day；One after each meal.7 days are a course for the treatment of, take the 2-4 course for the treatment of and are commented
Valency.
Control group 2：Take Gu Yu Ling Capsules, 8Hongfu Yiyue Pharmaceutical Co., Ltd., Shaanxi's production.Orally, once
5,3 times a day；One after each meal.7 days are a course for the treatment of, take the 2-4 course for the treatment of and are evaluated.
Control group 3：Take prescription in the patent document embodiment according to Application No. " 200910017891.0 "
Powder is made.It is for oral administration, each taking 6-9 grams, warm boiled water, 2 times a day, morning and evening aftermeals.7 days
For 1 course for the treatment of, take the 2-4 course for the treatment of and evaluated.
Experimental group：Take the pill of the embodiment of the present invention 5.3 times a day, each 6g；Children's decrement.Wound exists
Taken after upper body, food；Hinder in navel lower portion, it is before meals.7 days are a course for the treatment of, take 2-4 course for the treatment of progress
Evaluate.
4th, efficacy assessment standard
Cure：Fracture is recovered completely, and health is as before；
Effectively：Fracture symptom take a favorable turn or is clearly better, and needs continual cure or proceeds with reference to other methods
Treatment；
It is invalid：Fracture takes a turn for the better without any, even there is the trend of deterioration.
5th, statistical disposition
After 2~4 course of therapy, each group patient profiles, clinical therapeutic efficacy situation statistical result are checked
It is shown in Table 1.
The clinical therapeutic efficacy situation of table 1 is counted
6th, clinical typical case：
Korea Spro, man, 49 years old, Shaanxi people from Hua County, high-rise working was fractured the right legs accidentally, in before in September, 2012
To see a doctor, through 2 courses for the treatment of, sb.'s illness took a favorable turn, and 4 courses for the treatment of are cured.
Liu, man, 13 years old, Shaanxi Bin County people, left arm fracture when being played with partner, in 2 months 2013 years
Come to see a doctor, through 1 course for the treatment of, sb.'s illness took a favorable turn, 3 courses for the treatment of are cured.
Lee, female, 62 years old, people from Xianyang, with eye illness, blurred vision is thrown from a heatable brick bed accidentally,
Right arm fracture, comes to see a doctor, through 2 courses for the treatment of, sb.'s illness took a favorable turn in May, 2013, and 4 courses for the treatment of are cured.
Zhang, female, 24 years old, Shaanxi people from Qian County caused thigh bone to be fractured during cycling.Come in May, 2014
See a doctor, through 1 course for the treatment of, sb.'s illness took a favorable turn, 3 courses for the treatment of are cured.
Claims (7)
1. a kind of Chinese medicine composition for treating fracture, it is characterised in that by the bulk drug of following weight
Composition：30-90 parts of pseudo-ginseng, 60-120 parts of levisticum, 5-20 parts of dragon's blood, 50-110 parts of myrrh, Radix Angelicae Sinensis 120-180
Part, 5-20 parts of prepared nux vomica, 250-350 parts of muskmelon seed, 60-120 parts of ground bettle, 60-120 parts of safflower,
60-120 parts of cassia twig, 50-110 parts of frankincense, 30-70 parts of Ligusticum wallichii, 50-110 parts of earthworm, 30-90 parts of root tuber of aromatic turmeric,
150-250 parts of the rhizome of davallia, 80-160 parts of teasel root, 60-120 parts of native copper, 30-70 parts of the root of Dahurain angelica.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that by the original of following weight
Expect medicine composition：50-70 parts of pseudo-ginseng, 80-100 parts of levisticum, 8-12 parts of dragon's blood, 70-90 parts of myrrh, Radix Angelicae Sinensis
140-160 parts, 8-12 parts of prepared nux vomica, 280-320 parts of muskmelon seed, 80-100 parts of ground bettle, safflower 80-100
Part, 80-100 parts of cassia twig, 70-90 parts of frankincense, 40-60 parts of Ligusticum wallichii, 70-90 parts of earthworm, root tuber of aromatic turmeric 50-70
Part, 180-220 parts of the rhizome of davallia, 100-140 parts of teasel root, 80-100 parts of native copper, 40-60 parts of the root of Dahurain angelica.
3. Chinese medicine composition as claimed in claim 2, it is characterised in that by the original of following weight
Expect medicine composition：60 parts of pseudo-ginseng, 90 parts of levisticum, 10 parts of dragon's blood, 80 parts of myrrh, 150 parts of Radix Angelicae Sinensis, horse
10 parts of money powder, 300 parts of muskmelon seed, 90 parts of ground bettle, 90 parts of safflower, 90 parts of cassia twig, frankincense 80
Part, 50 parts of Ligusticum wallichii, 80 parts of earthworm, 60 parts of root tuber of aromatic turmeric, 200 parts of the rhizome of davallia, 120 parts of teasel root, native copper
90 parts, 50 parts of the root of Dahurain angelica.
4. the Chinese medicine composition as described in claim 1-3 is any, it is characterised in that the Chinese medicine composition is
Contain or not contain the various conventional extract oral medicine dosage forms of pharmaceutic adjuvant.
5. Chinese medicine composition as claimed in claim 4, it is characterised in that the preparation be powder, tablet,
Granule, capsule or pill.
6. the method for Chinese medicine composition as claimed in claim 5, it is characterised in that the preparation side of the preparation
Method is as follows：The bulk drug of each weight is taken, be dry, pulverize, granularity is 80-120 mesh, through ultraviolet
After radiation sterilization processing, it is molded according to conventional preparation process.
7. application of the Chinese medicine composition in treatment fracture medicine is prepared as described in claim 1-5 is any.
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| CN108524868A (en) * | 2018-05-25 | 2018-09-14 | 蒙开科 | The seedling medicine of fast fracture-setting |
| EP3903798A1 (en) * | 2020-04-27 | 2021-11-03 | Lulin Wang | Bone-strengthening pill (bsp) as a dietary supplement to improve blood circulation and strengthen bone and muscle |
| CN114224965A (en) * | 2022-02-07 | 2022-03-25 | 左道奇 | Traditional Chinese medicine composition for treating bone fracture and preparation method and base patch thereof |
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| CN108524868A (en) * | 2018-05-25 | 2018-09-14 | 蒙开科 | The seedling medicine of fast fracture-setting |
| EP3903798A1 (en) * | 2020-04-27 | 2021-11-03 | Lulin Wang | Bone-strengthening pill (bsp) as a dietary supplement to improve blood circulation and strengthen bone and muscle |
| CN114224965A (en) * | 2022-02-07 | 2022-03-25 | 左道奇 | Traditional Chinese medicine composition for treating bone fracture and preparation method and base patch thereof |
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