CN114224965A - Traditional Chinese medicine composition for treating bone fracture and preparation method and base patch thereof - Google Patents
Traditional Chinese medicine composition for treating bone fracture and preparation method and base patch thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating bone fracture as well as a preparation method and a base plaster thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for treating bone fracture is prepared from the following raw materials in parts by weight: 1-2 parts of nux vomica, 2.5-5 parts of frankincense, 2-4 parts of myrrh, 1-2 parts of dragon's blood, 1-2 parts of native copper, 1.5-3 parts of angelica dahurica, 3-6 parts of ground beetle, 1.5-3 parts of cucumber seed, 0.5-1 part of natural indigo, 0.8-1.6 parts of borneol, 6-12 parts of ligusticum wallichii, 6-12 parts of rhizoma drynariae, 9-18 parts of fine cassia twig, 6-12 parts of sappan wood, 9-18 parts of teasel root, 3-6 parts of ulmus macrocarpa bark extract and 0.5-1 part of xanthan gum powder. The traditional Chinese medicine composition for treating bone fracture, the preparation method and the base plaster provided by the embodiment of the invention can fully exert the medicinal efficacy of the traditional Chinese medicine preparation, and can effectively treat closed bone fracture, bone and muscle tissue sprain and contusion.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating bone fracture, a preparation method thereof and a base patch.
Background
Closed bone fracture refers to that the integrity of bones of human bodies is destroyed or continuously interrupted due to various traumatic factors, severe patients can have malformation of skeletal structures, abnormal activities and fricative sound (fricative feeling), and severe pain, local blood stasis and swelling can be accompanied, severe multiple fracture can even cause shock, and the life is threatened.
Sprain and contusion of muscle and bone tissue refers to the injury of muscle, tendon, ligament, joint, fascia and other tissues accompanied with bone destruction caused by various traumatic factors, usually manifested as local pain.
According to the related medical research, the traditional closed bone fracture and fracture patients are usually fixed by incising the affected part through an operation and using special equipment or resetting by adopting a traditional method and externally fixing by using plaster and splints so as to achieve the purpose of treatment. However, after the fracture of the patient is healed, the fixing device placed in the patient needs to be taken out, which easily causes secondary tissue trauma and generates high treatment cost. And most of the cured patients are in physical labor or in rainy and cold days within 1-3 years of cure, and sequelae such as swelling, cold pain and the like easily and repeatedly appear on the affected part and cannot be solved. Modern medical research data of trauma and bone fracture show that the key factors influencing the healing speed of the bone fracture and the bone fracture are the swelling, pain and the dissipation time of blood stasis of the bone fracture and the bone fracture, which are the fundamental factors for establishing normal blood circulation of the injured part and the key factors influencing the healing of the bone fracture and the bone fracture. The existing western medicine therapy can not achieve satisfactory treatment effect, and the result of traditional Chinese medicine treatment is not ideal.
Disclosure of Invention
The embodiment of the invention aims to provide a traditional Chinese medicine composition for treating bone fracture, a preparation method thereof and a base patch, which can fully exert the medicinal efficacy of a traditional Chinese medicine preparation and more effectively treat closed bone fracture, bone fracture and bone and muscle tissue sprain and contusion.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition for treating bone fracture is prepared from the following raw materials in parts by weight: 1-2 parts of nux vomica, 2.5-5 parts of frankincense, 2-4 parts of myrrh, 1-2 parts of dragon's blood, 1-2 parts of native copper, 1.5-3 parts of angelica dahurica, 3-6 parts of ground beetle, 1.5-3 parts of cucumber seed, 0.5-1 part of natural indigo, 0.8-1.6 parts of borneol, 6-12 parts of ligusticum wallichii, 6-12 parts of rhizoma drynariae, 9-18 parts of fine cassia twig, 6-12 parts of sappan wood, 9-18 parts of teasel root, 3-6 parts of ulmus macrocarpa bark extract and 0.5-1 part of xanthan gum powder.
In some embodiments, the composition is prepared from the following raw materials in parts by weight: 1 part of nux vomica, 2.5 parts of frankincense, 2 parts of myrrh, 1 part of dragon's blood, 1 part of native copper, 1.5 parts of angelica dahurica, 3 parts of ground beeltle, 1.5 parts of cucumber seed, 0.5 part of indigo naturalis, 0.8 part of borneol, 6 parts of ligusticum wallichii, 6 parts of rhizoma drynariae, 9 parts of fine cassia twig, 6 parts of sappan wood, 9 parts of teasel root, 3 parts of ulmus macrocarpa bark extract and 0.5 part of xanthan gum powder.
In some embodiments, the composition is prepared from the following raw materials in parts by weight: 1.5 parts of nux vomica, 3.8 parts of frankincense, 3 parts of myrrh, 1.5 parts of dragon's blood, 1.5 parts of native copper, 2.3 parts of angelica dahurica, 4.5 parts of ground beetle, 2.3 parts of cucumber seed, 0.8 part of indigo naturalis, 1.2 parts of borneol, 9 parts of ligusticum wallichii, 9 parts of drynaria rhizome, 13.5 parts of fine cassia twig, 9 parts of sappan wood, 13.5 parts of teasel root, 4.5 parts of ulmus macrocarpa bark extract and 0.8 part of xanthan gum powder.
In some embodiments, the composition is prepared from the following raw materials in parts by weight: 2 parts of nux vomica, 5 parts of frankincense, 4 parts of myrrh, 2 parts of dragon's blood, 2 parts of native copper, 3 parts of angelica dahurica, 6 parts of ground beetle, 3 parts of cucumber seed, 1 part of natural indigo, 1.6 parts of borneol, 12 parts of ligusticum wallichii, 12 parts of rhizoma drynariae, 18 parts of fine cassia twig, 12 parts of sappan wood, 18 parts of teasel root, 6 parts of ulmus macrocarpa bark extract and 1 part of xanthan gum powder.
Some embodiments of the present invention further provide a method for preparing a traditional Chinese medicine composition for treating bone fracture, which adopts the traditional Chinese medicine composition according to any one of the embodiments above, and comprises the following steps:
step S100: the A group of medicines: drying and crushing nux vomica, frankincense, myrrh, dragon's blood, native copper, angelica dahurica, ground beeltle and cucumber seed into traditional Chinese medicine powder to obtain powder a for storage;
step S200: and B group of medicines: grinding indigo naturalis and Borneolum Syntheticum into fine powder to obtain powder b, and storing;
step S300: and C, mixing the medicines: soaking rhizoma Ligustici Chuanxiong, rhizoma Drynariae, ramulus Cinnamomi, lignum sappan, and radix Dipsaci in ethanol solution, extracting, distilling, recovering ethanol, concentrating to obtain medicinal liquid c, and storing;
step S400: and (3) mixing the medicines in the group D: mixing cortex Ulmi Pumilae extract and xanthan powder to obtain powder d;
step S500: and adding the powder d into the liquid medicine c, stirring at constant temperature until no granular thick paste exists, adding the powder a, fully stirring until no granules exist, finally adding the powder b, fully stirring until no granular thick paste exists, cooling to room temperature, subpackaging and sealing for later use.
In some embodiments, in step S100, the group a drugs are dried and pulverized into 200-mesh traditional Chinese medicine powder, and powder a is stored for later use; in step S200, the group B drugs are ground into 300-mesh fine powder, and the powder B is stored for later use.
In some embodiments, in the step S300, the group C medicine is soaked in a 70% -80% ethanol solution 50L-70L, and soaked under a constant temperature of 30-50 ℃ for 40-50 hours.
In some embodiments, in step S300, the ultrasonic extraction method is adopted to extract twice, the liquid medicine is filtered, and the ethanol concentrated liquid medicine is distilled and extracted at a constant temperature of 70-90 ℃ to recover 10L-30L, so as to obtain liquid medicine c to be stored for later use.
In some embodiments, in the step S500, the liquid medicine c is put into a constant temperature stirring pot and heated to a constant temperature of 70 ℃ to 90 ℃, and then the powder d is added.
Some embodiments of the present invention further provide a base patch of a traditional Chinese medicine composition for treating bone fracture, which adopts the traditional Chinese medicine composition according to any one of the above embodiments, and comprises: the bottom sticker, the non-woven fabric and the silicone oil paper easy-to-tear strip are sequentially connected; one side of the bottom close to the non-woven fabric is coated with medical hot-melt pressure-sensitive adhesive, and the non-woven fabric is coated with a traditional Chinese medicine composition.
In the medicine, the functions of the raw medicinal materials are as follows:
dragon's blood: for traumatic injury, swelling and pain due to blood stasis, it is essential to activate blood and dissipate blood stasis; nux vomica: bitter and cold, disperse stagnation and relieve swelling, dredge collaterals and relieve pain; the frankincense and the myrrh have the effects of regulating qi and blood, promoting blood circulation to remove blood stasis, removing blood stasis, and relieving swelling and pain; myrrh also has the effect of promoting granulation, frankincense has the effect of relieving the toxicity of various medicines; native copper: pungent and even with the actions of dissipating blood stasis, knitting bone and alleviating pain. The five medicines are mutually compatible and have good effects of regulating qi, dredging collaterals, removing blood stasis, dissipating blood stasis, setting bone, treating contusion and sprain, and relieving swelling and pain, and are monarch medicines.
Ligusticum wallichii: move qi and unblock collaterals, activate blood and remove stasis, which are qi-activating herbs in activating blood; sappan wood: regulating qi-flowing, dredging collaterals, promoting blood circulation, removing blood stasis, relieving swelling and pain; teasel root: promoting qi circulation, removing blood stasis and swelling, strengthening bone, and promoting reunion of bone; ground beetle: breaking blood and resolving stasis, dissipating blood and keeping blood in the body, collecting the blood from meridians, it is the essential herb for reunion of fractured tendons and bones. The compatibility of the four medicines has the effects of promoting qi and blood circulation, dredging channels and collaterals, activating blood circulation, removing blood stasis, reuniting bones and muscles, relieving swelling and pain, and the effect of assisting the monarch medicine is the ministerial medicine.
Rhizoma drynariae: tonify liver and kidney, strengthen tendons and bones, promote blood circulation to stop pain, and continue the muscles and bones; cucumber seeds: strengthen tendons and bones and promote the repair and regeneration of tissue cells. The two medicines are used together to have the effects of promoting blood circulation, relieving pain, strengthening tendons and bones and continuing to strengthen tendons, and are used as adjuvant medicines.
Ramulus cinnamomi: warming channels, dredging collaterals, relieving spasm and pain of tendons and vessels; radix angelicae: good medicine for promoting blood circulation, removing obstruction, promoting granulation, and relieving pain due to muscle and bone contusion. The two herbs are combined with meridian-warming and collateral-dredging herbs to activate blood and relieve pain caused by muscle contusion and muscle damage, so they are guiding herbs.
Indigo naturalis and Borneolum Syntheticum are the subordinate medicines for clearing away heat and toxic materials, cooling blood, removing ecchymoses, inducing resuscitation, relieving swelling and pain, and relieving the toxicity of various medicines due to warm and dry.
The compatibility of the medicines is good for monarch, minister, assistant, guide and guide, and the good effects of removing blood stasis, dissipating blood stasis, removing blood stasis, relieving swelling and pain and reuniting bones and muscles are achieved together.
The ulmus macrocarpa bark extract and the xanthan gum powder are used as matrixes of the traditional Chinese medicine composition, and the traditional Chinese medicine composition is used for harmonizing the medicines and enhancing the viscosity of the medicines so as to be pasty.
The Chinese medicinal composition has the following indications: closed bone injury, fracture, sprain and contusion of bone and muscle tissue.
Contraindications of the traditional Chinese medicine composition of the invention are as follows: it is contraindicated for pregnant women and lying-in women, patients with skin rupture and ulceration of affected part, and patients with allergy.
The attention points of the traditional Chinese medicine composition are as follows: the normal anatomical position of the fracture is kept during the medication period so as to avoid malposition healing.
The invention provides a traditional Chinese medicine composition for treating bone fracture, which has the advantages that through reasonable compatibility of the medicines, the medicines generate good synergistic effect on curative effect, and the traditional Chinese medicine composition has the effects of removing blood stasis, dissipating blood stasis and removing blood stasis, relieving swelling and pain, and reuniting bones and tendons. Compared with the prior art, the traditional Chinese medicine composition has the advantages of quick pain relieving, quick disappearance of blood stasis and swelling, quick healing of fracture, quick callus formation at the healing part of the bone injury, quick disappearance of fracture lines and compact bone. The traditional Chinese medicine composition provided by the invention has four physical properties of stability, rheological property, moisture retention and adhesiveness.
Detailed Description
The technical solutions in some embodiments of the present disclosure are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present disclosure, and not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments provided by the present disclosure belong to the protection scope of the present disclosure.
Throughout the specification and claims, the term "comprising" is to be interpreted in an open, inclusive sense, i.e., as "including, but not limited to," unless the context requires otherwise. In the description herein, the terms "one embodiment," "some embodiments," "an example embodiment," "an example" or "some examples" or the like are intended to indicate that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the disclosure. The schematic representations of the above terms are not necessarily referring to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be included in any suitable manner in any one or more embodiments or examples.
Example 1
A traditional Chinese medicine composition for treating bone fracture is prepared from the following raw materials in parts by weight:
1 part of nux vomica, 2.5 parts of frankincense, 2 parts of myrrh, 1 part of dragon's blood, 1 part of native copper, 1.5 parts of angelica dahurica, 3 parts of ground beeltle, 1.5 parts of cucumber seed, 0.5 part of indigo naturalis, 0.8 part of borneol, 6 parts of ligusticum wallichii, 6 parts of rhizoma drynariae, 9 parts of fine cassia twig, 6 parts of sappan wood, 9 parts of teasel root, 3 parts of ulmus macrocarpa bark extract and 0.5 part of xanthan gum powder.
The preparation method of the traditional Chinese medicine composition for treating bone fracture comprises the following steps:
step S100: the A group of medicines: drying and crushing nux vomica, frankincense, myrrh, dragon's blood, native copper, angelica dahurica, ground beeltle and cucumber seed into 200-mesh Chinese medicinal powder, and storing the powder a for later use;
step S200: and B group of medicines: grinding indigo naturalis and Borneolum Syntheticum into 300 mesh fine powder to obtain powder b, and storing;
step S300: and C, mixing the medicines: soaking rhizoma Ligustici Chuanxiong, rhizoma Drynariae, ramulus Cinnamomi, lignum sappan, and radix Dipsaci in 75% ethanol solution 60L, soaking at constant temperature of 40 deg.C for 48 hr, extracting twice by ultrasonic extraction, filtering to obtain medicinal liquid, distilling at constant temperature of 80 deg.C, recovering ethanol, concentrating to 20L, and storing to obtain medicinal liquid c;
step S400: and (3) mixing the medicines in the group D: mixing cortex Ulmi Pumilae extract and xanthan powder to obtain powder d;
step S500: and putting the liquid medicine c into a constant-temperature stirring pot, heating to a constant temperature of 80 ℃, adding the powder d, stirring at a constant temperature until no granular thick paste exists, adding the powder a, fully stirring until no granules exist, finally adding the powder b, fully stirring until no granular thick paste exists, cooling to room temperature, subpackaging and sealing for later use.
Example 2
A traditional Chinese medicine composition for treating bone fracture is prepared from the following raw materials in parts by weight:
1.5 parts of nux vomica, 3.8 parts of frankincense, 3 parts of myrrh, 1.5 parts of dragon's blood, 1.5 parts of native copper, 2.3 parts of angelica dahurica, 4.5 parts of ground beetle, 2.3 parts of cucumber seed, 0.8 part of indigo naturalis, 1.2 parts of borneol, 9 parts of ligusticum wallichii, 9 parts of drynaria rhizome, 13.5 parts of fine cassia twig, 9 parts of sappan wood, 13.5 parts of teasel root, 4.5 parts of ulmus macrocarpa bark extract and 0.8 part of xanthan gum powder.
The preparation method of the traditional Chinese medicine composition for treating bone fracture comprises the following steps:
step S100: the A group of medicines: drying and crushing nux vomica, frankincense, myrrh, dragon's blood, native copper, angelica dahurica, ground beeltle and cucumber seed into traditional Chinese medicine powder of 300 meshes to obtain powder a for storage and later use;
step S200: and B group of medicines: grinding indigo naturalis and Borneolum Syntheticum into 200 mesh fine powder, and storing the powder b for use;
step S300: and C, mixing the medicines: soaking rhizoma Ligustici Chuanxiong, rhizoma Drynariae, ramulus Cinnamomi, lignum sappan, and radix Dipsaci in 70% ethanol solution 50L at constant temperature of 40 deg.C for 50 hr, extracting twice by ultrasonic extraction, filtering to obtain medicinal liquid, distilling at constant temperature of 70 deg.C, recovering ethanol, concentrating to 20L, and storing to obtain medicinal liquid c;
step S400: and (3) mixing the medicines in the group D: mixing cortex Ulmi Pumilae extract and xanthan powder to obtain powder d;
step S500: and (3) putting the liquid medicine c into a constant-temperature stirring pot, heating to a constant temperature of 70 ℃, adding the powder d, stirring at a constant temperature until no granular thick paste exists, adding the powder a, fully stirring until no granules exist, finally adding the powder b, fully stirring until no granular thick paste exists, cooling to room temperature, subpackaging and sealing for later use.
Example 3
A traditional Chinese medicine composition for treating bone fracture is prepared from the following raw materials in parts by weight:
2 parts of nux vomica, 5 parts of frankincense, 4 parts of myrrh, 2 parts of dragon's blood, 2 parts of native copper, 3 parts of angelica dahurica, 6 parts of ground beetle, 3 parts of cucumber seed, 1 part of natural indigo, 1.6 parts of borneol, 12 parts of ligusticum wallichii, 12 parts of rhizoma drynariae, 18 parts of fine cassia twig, 12 parts of sappan wood, 18 parts of teasel root, 6 parts of ulmus macrocarpa bark extract and 1 part of xanthan gum powder.
The preparation method of the traditional Chinese medicine composition for treating bone fracture comprises the following steps:
step S100: the A group of medicines: drying and crushing nux vomica, frankincense, myrrh, dragon's blood, native copper, angelica dahurica, ground beeltle and cucumber seed into 200-mesh Chinese medicinal powder, and storing the powder a for later use;
step S200: and B group of medicines: grinding indigo naturalis and Borneolum Syntheticum into 300 mesh fine powder to obtain powder b, and storing;
step S300: and C, mixing the medicines: soaking rhizoma Ligustici Chuanxiong, rhizoma Drynariae, ramulus Cinnamomi, lignum sappan, and radix Dipsaci in 70-80% ethanol solution 50L-70L, soaking at constant temperature of 30-50 deg.C for 40-50 hr, extracting twice by ultrasonic extraction, filtering to obtain medicinal liquid, distilling at constant temperature of 70-90 deg.C, recovering ethanol, concentrating to 10L-30L, and storing to obtain medicinal liquid c;
step S400: and (3) mixing the medicines in the group D: mixing cortex Ulmi Pumilae extract and xanthan powder to obtain powder d;
step S500: and putting the liquid medicine c into a constant-temperature stirring pot, heating to a constant temperature of 70-90 ℃, adding the powder d, stirring at a constant temperature until no granular thick paste exists, adding the powder a, fully stirring until no granules exist, adding the powder b, fully stirring until no granular thick paste exists, cooling to room temperature, subpackaging and sealing for later use.
Example 4
A traditional Chinese medicine composition for treating bone fracture is prepared from the following raw materials in parts by weight:
1.5 parts of nux vomica, 2 parts of frankincense, 2 parts of myrrh, 1 part of dragon's blood, 1 part of native copper, 1 part of angelica dahurica, 4 parts of ground beeltle, 2 parts of cucumber seed, 0.8 part of natural indigo, 0.8 part of borneol, 9 parts of ligusticum wallichii, 9 parts of rhizoma drynariae, 12 parts of fine cassia twig, 8 parts of sappan wood, 9 parts of teasel root, 5 parts of ulmus macrocarpa bark extract and 0.5 part of xanthan gum powder.
The preparation method of the traditional Chinese medicine composition for treating bone fracture is referred to example 1 and is not described again.
Example 5
A traditional Chinese medicine composition for treating bone fracture is prepared from the following raw materials in parts by weight:
1 part of nux vomica, 2 parts of frankincense, 2.5 parts of myrrh, 1.5 parts of dragon's blood, 1.5 parts of native copper, 1.5 parts of angelica dahurica, 3 parts of ground beetle, 2 parts of cucumber seed, 0.5 part of indigo naturalis, 1.2 parts of borneol, 6 parts of ligusticum wallichii, 6 parts of drynaria rhizome, 18 parts of fine cassia twig, 12 parts of sappan wood, 9 parts of dipsacus asperoides, 6 parts of ulmus macrocarpa bark extract and 0.5 part of xanthan gum powder.
The preparation method of the traditional Chinese medicine composition for treating bone fracture is referred to example 1 and is not described again.
Example 6
A traditional Chinese medicine composition for treating bone fracture is prepared from the following raw materials in parts by weight:
1.5 parts of nux vomica, 4 parts of frankincense, 4 parts of myrrh, 1.5 parts of dragon's blood, 1.5 parts of native copper, 2 parts of angelica dahurica, 5 parts of ground beetle, 2 parts of cucumber seed, 1 part of indigo naturalis, 1.2 parts of borneol, 10 parts of ligusticum wallichii, 10 parts of rhizoma drynariae, 15 parts of fine cassia twig, 12 parts of sappan wood, 16 parts of teasel root, 5 parts of ulmus macrocarpa bark extract and 1 part of xanthan gum powder.
The preparation method of the traditional Chinese medicine composition for treating bone fracture is referred to example 1 and is not described again.
Some embodiments of the present invention provide a base patch of a traditional Chinese medicine composition for treating bone fracture, which employs the traditional Chinese medicine composition described in any one of the above embodiments, and the base patch of the traditional Chinese medicine composition comprises: the medical hot melt pressure sensitive adhesive is coated on one side of the bottom paste close to the non-woven fabric, and the non-woven fabric is coated with a traditional Chinese medicine composition.
The bottom patch is made of micro-elastic anti-seepage spunlace nonwoven fabric, the nonwoven fabric is bamboo charcoal fiber nonwoven fabric, and the Chinese medicinal composition is coated on the nonwoven fabric, and has a thickness of about 0.5 mm.
In some embodiments, the areas of the bottom sticker and the silicone oil paper easy-open strip are equal, and the area of the non-woven fabric is smaller than that of the bottom sticker. When the traditional Chinese medicine composition base is used for pasting, the silicone oil paper easy-to-uncover strip is firstly uncovered, the non-woven fabric coated with the traditional Chinese medicine composition is exposed, and the medical hot-melt pressure-sensitive adhesive coated by the bottom pasting, namely the medical hot-melt pressure-sensitive adhesive coated on the periphery of the non-woven fabric, is used for pasting the bottom pasting cover on the affected part, so that the traditional Chinese medicine composition in the non-woven fabric can cover the affected part, and the purpose of treating bone fracture is achieved.
Clinical efficacy observation of the Chinese medicinal composition of the invention
1. General data
The subjects selected 228 patients with closed limb fracture who were collected from 2015, 9 months to 2020, 9 months for clinical observation. 228 patients with limb fracture are divided into two groups at random, namely 114 patients in a treatment group and 114 patients in a control group, and the patients are 11-72 years old. The mean age of the patients in both groups was 41.5 ± 30.5 years. The difference in sex ratio between men and women is not statistically significant. Both clinically and by X-ray confirmed diagnosis, patients with closed traumatic fracture have no strict physical signs of gravity, brain, lung and kidney.
33 cases of ulna and radius fracture, 32 cases of humerus fracture, 28 cases of tibiofibula fracture and 21 cases of femoral fracture in the treatment group.
33 cases of ulna and radius fracture, 22 cases of humerus fracture, 36 cases of tibiofibula fracture and 23 cases of femur fracture in the control group. The difference between the fracture parts and the damage degrees of the two groups has no statistical significance. No significant difference was observed with statistical treatment of the disease cases (P > 0.05).
2. Diagnostic criteria
All cases refer to the diagnostic criteria of "clinical bone surgery".
3. Method of treatment
The displaced fracture is first reduced by conventional method or traction. Then the treatment group adopts the traditional Chinese medicine composition for treating bone fracture for external application, and the traditional Chinese medicine composition is replaced once in 72 hours. A course of treatment is 60 days for patients with bone fracture and sprain and contusion, and a course of treatment is 15 days for patients with bone fracture and fracture. The control group was not externally applied with the drug. Both groups are fixed by splints, plaster or traction. The reference group is taken in combination with the medicines for promoting blood circulation and removing blood stasis and the analgesics for adjuvant therapy.
4. Observation indexes are as follows:
1) the mean time to pain disappearance was compared between the two groups of patients.
2) The mean disappearance times of the extravasated blood swelling were compared between the two groups of patients.
3) The time to primary callus formation was compared between the two groups of patients.
4) The complete disappearance of the fracture line was compared between the two groups of patients.
5) Two groups of patients are followed and followed for 1 year to observe whether the two groups of patients have physical labor or are in overcast and rainy days or cold days, and the discomforts such as swelling, cold pain and the like occur repeatedly on the affected part for statistics.
5. Results and analysis (see tables 1-2)
Table 1: index data of two groups of patients for observation
Table 2: follow-up statistics of sequelae after fracture healing of two groups of patients
It can be seen from tables 1 and 2 that the therapeutic effects of the treatment groups were significantly superior to those of the control group (p <0.001) in the average pain disappearance time, average extravasated blood swelling disappearance time, original callus formation time, complete disappearance of fracture line, and incidence of sequelae after fracture healing.
The traditional Chinese medicines are compatible with each other, so that the synergistic treatment effect can be exerted, the components of the raw materials of the traditional Chinese medicines have the efficacy of mutual interweaving, mutual promotion and coordination, and clinical verification proves that the traditional Chinese medicine is suitable for closed bone injuries, fractures and sprain and contusion of muscle and bone tissues of all parts of a human body, can relax tendons and activate collaterals, remove stasis and promote tissue regeneration, stop bleeding and relieve pain.
Finally, the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting, and other modifications or equivalent substitutions made by the technical solutions of the present invention by those of ordinary skill in the art should be covered within the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating bone fracture is characterized by being prepared from the following raw materials in parts by weight:
1-2 parts of nux vomica, 2.5-5 parts of frankincense, 2-4 parts of myrrh, 1-2 parts of dragon's blood, 1-2 parts of native copper, 1.5-3 parts of angelica dahurica, 3-6 parts of ground beetle, 1.5-3 parts of cucumber seed, 0.5-1 part of natural indigo, 0.8-1.6 parts of borneol, 6-12 parts of ligusticum wallichii, 6-12 parts of rhizoma drynariae, 9-18 parts of fine cassia twig, 6-12 parts of sappan wood, 9-18 parts of teasel root, 3-6 parts of ulmus macrocarpa bark extract and 0.5-1 part of xanthan gum powder.
2. The traditional Chinese medicine composition of claim 1, which is prepared from the following raw materials in parts by weight:
1 part of nux vomica, 2.5 parts of frankincense, 2 parts of myrrh, 1 part of dragon's blood, 1 part of native copper, 1.5 parts of angelica dahurica, 3 parts of ground beeltle, 1.5 parts of cucumber seed, 0.5 part of indigo naturalis, 0.8 part of borneol, 6 parts of ligusticum wallichii, 6 parts of rhizoma drynariae, 9 parts of fine cassia twig, 6 parts of sappan wood, 9 parts of teasel root, 3 parts of ulmus macrocarpa bark extract and 0.5 part of xanthan gum powder.
3. The traditional Chinese medicine composition of claim 1, which is prepared from the following raw materials in parts by weight:
1.5 parts of nux vomica, 3.8 parts of frankincense, 3 parts of myrrh, 1.5 parts of dragon's blood, 1.5 parts of native copper, 2.3 parts of angelica dahurica, 4.5 parts of ground beetle, 2.3 parts of cucumber seed, 0.8 part of indigo naturalis, 1.2 parts of borneol, 9 parts of ligusticum wallichii, 9 parts of drynaria rhizome, 13.5 parts of fine cassia twig, 9 parts of sappan wood, 13.5 parts of teasel root, 4.5 parts of ulmus macrocarpa bark extract and 0.8 part of xanthan gum powder.
4. The traditional Chinese medicine composition of claim 1, which is prepared from the following raw materials in parts by weight:
2 parts of nux vomica, 5 parts of frankincense, 4 parts of myrrh, 2 parts of dragon's blood, 2 parts of native copper, 3 parts of angelica dahurica, 6 parts of ground beetle, 3 parts of cucumber seed, 1 part of natural indigo, 1.6 parts of borneol, 12 parts of ligusticum wallichii, 12 parts of rhizoma drynariae, 18 parts of fine cassia twig, 12 parts of sappan wood, 18 parts of teasel root, 6 parts of ulmus macrocarpa bark extract and 1 part of xanthan gum powder.
5. A preparation method of a traditional Chinese medicine composition for treating bone fracture, which adopts the traditional Chinese medicine composition as claimed in any one of claims 1 to 4, is characterized by comprising the following steps:
step S100: the A group of medicines: drying and crushing nux vomica, frankincense, myrrh, dragon's blood, native copper, angelica dahurica, ground beeltle and cucumber seed into traditional Chinese medicine powder to obtain powder a for storage;
step S200: and B group of medicines: grinding indigo naturalis and Borneolum Syntheticum into fine powder to obtain powder b, and storing;
step S300: and C, mixing the medicines: soaking rhizoma Ligustici Chuanxiong, rhizoma Drynariae, ramulus Cinnamomi, lignum sappan, and radix Dipsaci in ethanol solution, extracting, distilling, recovering ethanol, concentrating to obtain medicinal liquid c, and storing;
step S400: and (3) mixing the medicines in the group D: mixing cortex Ulmi Pumilae extract and xanthan powder to obtain powder d;
step S500: and adding the powder d into the liquid medicine c, stirring at constant temperature until no granular thick paste exists, adding the powder a, fully stirring until no granules exist, finally adding the powder b, fully stirring until no granular thick paste exists, cooling to room temperature, subpackaging and sealing for later use.
6. The method for preparing a Chinese medicinal composition according to claim 5,
in the step S100, the group a medicines are dried and crushed into 200-mesh traditional Chinese medicine powder, and powder a is obtained and stored for later use;
in step S200, the group B drugs are ground into 300-mesh fine powder, and the powder B is stored for later use.
7. The method for preparing a Chinese medicinal composition according to claim 5,
in the step S300, the group C medicines are soaked in 50L-70L of 70-80% ethanol solution and soaked for 40-50 hours at the constant temperature of 30-50 ℃.
8. The method for preparing a Chinese medicinal composition according to claim 5,
in the step S300, an ultrasonic extraction method is adopted for two times, liquid medicine is filtered out, and the ethanol concentrated liquid medicine is distilled and extracted at the constant temperature of 70-90 ℃ and recovered to 10L-30L, so that liquid medicine c is obtained and stored for later use.
9. The method for preparing a Chinese medicinal composition according to claim 5,
in the step S500, the liquid medicine c is firstly put into a constant-temperature stirring pot and heated to the constant temperature of 70-90 ℃, and then the powder d is added.
10. A base patch of a traditional Chinese medicine composition for treating bone fracture, which adopts the traditional Chinese medicine composition as claimed in any one of claims 1 to 4, and is characterized by comprising:
the bottom sticker, the non-woven fabric and the silicone oil paper easy-to-tear strip are sequentially connected;
one side of the bottom close to the non-woven fabric is coated with medical hot-melt pressure-sensitive adhesive, and the non-woven fabric is coated with a traditional Chinese medicine composition.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903246A (en) * | 2006-08-05 | 2007-01-31 | 任逸仙 | Medicine for setting broken bone |
| CN1977933A (en) * | 2005-12-01 | 2007-06-13 | 秦秀前 | Bone-setting medicine and its use method |
| CN100998767A (en) * | 2006-12-29 | 2007-07-18 | 张秋霞 | Traditional Chinese medicine for treating fracture and its preparing method |
| CN107115493A (en) * | 2016-02-24 | 2017-09-01 | 王小庆 | It is a kind of to treat Chinese medicine composition of fracture and its production and use |
| CN109718321A (en) * | 2019-03-22 | 2019-05-07 | 马子轩 | It is a kind of to treat the broken bonesetting Chinese medicine and preparation method thereof of fracture, bone |
| CN111643620A (en) * | 2020-06-15 | 2020-09-11 | 厦门市同安区金榜中草药种植场 | Pure Chinese herbal medicine bonesetting medicine |
| CN114209764A (en) * | 2022-01-14 | 2022-03-22 | 包头云龙骨科医院有限责任公司 | Pharmaceutical composition for treating bone fracture, preparation and application |
-
2022
- 2022-02-07 CN CN202210120383.0A patent/CN114224965A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977933A (en) * | 2005-12-01 | 2007-06-13 | 秦秀前 | Bone-setting medicine and its use method |
| CN1903246A (en) * | 2006-08-05 | 2007-01-31 | 任逸仙 | Medicine for setting broken bone |
| CN100998767A (en) * | 2006-12-29 | 2007-07-18 | 张秋霞 | Traditional Chinese medicine for treating fracture and its preparing method |
| CN107115493A (en) * | 2016-02-24 | 2017-09-01 | 王小庆 | It is a kind of to treat Chinese medicine composition of fracture and its production and use |
| CN109718321A (en) * | 2019-03-22 | 2019-05-07 | 马子轩 | It is a kind of to treat the broken bonesetting Chinese medicine and preparation method thereof of fracture, bone |
| CN111643620A (en) * | 2020-06-15 | 2020-09-11 | 厦门市同安区金榜中草药种植场 | Pure Chinese herbal medicine bonesetting medicine |
| CN114209764A (en) * | 2022-01-14 | 2022-03-22 | 包头云龙骨科医院有限责任公司 | Pharmaceutical composition for treating bone fracture, preparation and application |
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Application publication date: 20220325 |