CN100484538C - Upper, middle and lower part soup, and method for making same - Google Patents

Abstract

The invention relates to a medicine for treating various fractures made from plant Chinese herbal medicine and a preparation method thereof. It is a medicament made from the raw materials in the following weight ratio: frankincense: myrrh: dipsacus: chuanxiong: safflower: calcined keel: psoralen: eucommia: oyster = 20-30: 20-30: 2 -3: 20-30: 20-30: 15-25: 25-35: 25-35: 15-25. The invention is a pure traditional Chinese medicine preparation, without toxic side effects and adverse reactions, without surgery for patients, with low cost of treatment, no pain, short healing period, high potency, quick effect, high cure rate, strong potency, and good effect on fractures in various parts and soft tissue damage. Excellent, promotes callus growth, nourishes blood, stimulates menstrual flow, promotes blood circulation and dissipates blood stasis, reduces swelling and relieves pain, and also has a good curative effect on femoral head necrosis, osteoporosis or other parts of osteonecrosis.

Description

Upper, middle and lower soups and preparation methods thereof

technical field

The invention relates to a pharmaceutical composition for treating various fractures, in particular to a medicine for treating various fractures made from plant Chinese herbal medicine and a preparation method thereof.

Background technique

The treatment method of existing bone injury generally adopts methods such as artificial bone setting, operation bone setting. With the help of X-ray machine or other means, after the fracture is reduced, it is fixed with a splint, plaster bandage or surgical plate, and it takes anti-inflammatory drugs or drugs for the treatment of bruises, and it rests for about three months. The infiltration effect of the drug makes the curative effect slow, and the patient's own factors may cause different degrees of overlapping and displacement of the fracture site, resulting in swelling and pain at the site, resulting in weakened or lost flexion and extension functions, which bring great harm to the patient. pain. If the surgical plate is used for fixation, after the fracture heals, a second operation is required to remove the plate and fixation nails. The pain caused to the patient can be imagined, and artificial screw holes are left on the bone. The bone that caused the fracture repairs again, and at the same time there is the possibility of infection with osteomyelitis. Although there are many medicines for the treatment of fractures at present, the softening and pain-relieving effects are not good, the bone healing time is long, and the patient suffers a lot.

Contents of the invention

The object of the present invention is to provide a kind of upper, middle and lower part soup for treating various fractures and its preparation method in view of the above problems. , Remarkable treatment effect, low cost, enriching blood and nourishing blood, promoting menstruation, promoting blood circulation and dissipating blood stasis, reducing swelling and relieving pain. Efficacy.

In order to realize the purpose of the present invention, the technical scheme adopted in the present invention is:

Upper, middle and lower part soups, which are medicaments made from raw materials with the following weight ratio: frankincense: myrrh: Dipsacus: Rhizoma Chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster=20- 30: 20-30: 2-3: 20-30: 20-30: 15-25: 25-35: 25-35: 15-25.

Wherein the weight ratio of each raw material is frankincense: making myrrh: Dipsacus: Rhizoma Chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster=22-28: 22-28: 2.2-2.8: 22-28: 22-28: 17-23: 27-32: 27-32: 17-23.

Wherein the weight ratio of each raw material is frankincense: making myrrh: Dipsacus: Rhizoma chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster=25: 25: 2.5: 25: 25: 20: 30: 30: 20.

The preparation method of the upper, middle and lower part of the soup, which is made of frankincense made of the following raw materials in weight ratio: making myrrh: Dipsacus: Chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster=20 -30: 20-30: 2-3: 20-30: 20-30: 15-25: 25-35: 25-35: 15-25;

Its preparation method comprises the following steps:

1. Pulverize each of the above-mentioned single-flavor medicinal pulverizers and pass through a 100-mesh sieve;

2. Take the pulverized single herbs according to the above ratio and mix them thoroughly;

3. Boil the mixed medicine and water at a ratio of 1:10 over medium heat until the water volume is half of the original.

Advantage and effect that the present invention has are:

1. The present invention is a pure traditional Chinese medicine preparation, without toxic side effects and adverse reactions, and does not need any artificial fixation methods such as splinting, plastering, and binding, which reduces the pain of the patient and also reduces the economic burden of the patient.

2. The present invention has short healing period and quick effect. Taking this medicine for 20 minutes can obviously relieve pain, and clinical practice proves that compared with traditional treatment methods, the course of treatment can be shortened by one-half.

3. The present invention is based on the family secret recipe, and has been clinically used for more than 40 years. Patients consistently report that the curative effect is very good, the drug effect is rapid, the total effective rate is 99%, and the marked rate is 96%.

4. The present invention has good curative effect on various fractures and bruises. At the same time, it has a good curative effect on femoral head necrosis, osteoporosis and osteonecrosis in other parts.

The frankincense nature and flavor are pungent, bitter, warm. Guixin, liver, spleen meridians; have the effects of promoting blood circulation and relieving pain, reducing swelling and promoting granulation. Myrrha nature and flavor are bitter, flat, belong to the heart, liver and spleen meridian; have the effect of promoting blood circulation and relieving pain. Continuously bitter, slightly warm. Go into liver, kidney channel; Have the effect of invigorating liver and kidney, renewing muscles and bones, regulating blood vessels. Rhizoma Chuanxiong is pungent and warm in nature and flavor, and returns to the Liver, Gallbladder, and Pericardium Meridians; it has the effects of promoting blood circulation and promoting Qi, dispelling wind and relieving pain. Safflower is pungent and warm in nature and flavor, enters the heart and liver meridians; it has the effects of promoting blood circulation, promoting menstruation, removing blood stasis and relieving pain. Calcined keel is sweet, astringent and flat in nature and flavor; Guixin, liver and kidney meridians; it has the effects of calming the nerves, calming the liver and suppressing yang, astringent and astringent. Psoraleae nature and flavor are pungent and warm, enter the Liver and Spleen Meridian; can invigorate the kidney and warm the spleen. Eucommia ulmoides is sweet in nature and flavor, slightly pungent, warm; returns to liver, kidney meridian; has the effect of nourishing liver and kidney, strengthening muscles and bones. Oysters are sweet and flat in taste, nourishing yin and nourishing blood, calming the heart and relieving restlessness.

Below in conjunction with clinical data, describe the drug effect of the present invention:

1. Clinical data

1.1 Source of cases: All cases were bone disease patients admitted to Shenyang Zhanggui Traditional Chinese Medicine Orthopedics and Traumatology Clinic from January 2000 to December 2003. They were randomly divided into treatment group (upper, middle and lower soup group) and control group (musk bone glue group). 100 cases in the treatment group and 100 cases in the control group, aged between 6 and 70 years old,

Table 1 Gender and age distribution

Table 2 Distribution of fracture sites

1.2 Case selection criteria

1.2.1 Diagnostic criteria (1) There is a clear history of trauma. (2) General symptoms: local pain, swelling and ecchymosis, dysfunction. (3) Special signs: deformity, bone friction sound or bone friction feeling, abnormal activity. (4) X-ray findings: The integrity and continuity of the confirmed bone have been destroyed.

1.2.2 The selection criteria of the cases met the diagnostic criteria. The main experimental subjects were fresh fractures of the extremities, external fixation with small splints and (or) plaster, incision internal fixation or external fixation with brackets, aged 6 to 70 years.

2. Method

2.1 Clinical Experimental Methods All cases were bone disease patients admitted to Shenyang Zhanggui Traditional Chinese Medicine Orthopedics and Traumatology Clinic from January 2000 to December 2003. They were randomly divided into treatment group (upper, middle and lower decoction group) and control group (Shexiang Jiegu Capsule group). The 100 patients in the treatment group took the upper, middle and lower decoctions of the drug orally, one dose per day for adults, and took it warmly three times in the morning, afternoon and evening. Half for children. Avoid taking raw onion, ginger, raw garlic, and radish during the medication, and pregnant women should take it with caution. 100 cases in the control group took Shexiang Jiegu Capsules, 5 capsules for adults and 2 capsules for children, 3 times a day. Continuous medication for 12 weeks, stop taking other bone medicines during treatment.

3. Results

3.1 Efficacy evaluation criteria (1) No local tenderness and longitudinal percussion pain; (2) No local abnormal activity; (3) X-ray film shows that the fracture line is blurred, with continuous callus passing through the fracture line; (4) Functional test: After lifting the immobilization, the upper limbs can lift 1 kg of weight for 1 minute, and the lower limbs can walk continuously for 3 minutes, and can walk no less than 30 steps; (5) After 2 weeks of continuous observation, the fracture does not deform, and the first day of observation is the date of clinical healing.

3.2 Common fracture healing time: 5-7 weeks for clavicle fractures; 4-6 weeks for humeral surgical neck fractures; 5-8 weeks for humeral shaft fractures; 3-4 weeks for humeral supracondylar fractures; 3-4 weeks for distal fractures; 4-8 weeks for metacarpal fractures; 6-10 weeks for trochanteric fractures; 8-14 weeks for femoral shaft fractures; 8-12 weeks for tibial and fibula fractures; 6-8 weeks for metatarsal fractures.

3.3 Efficacy Judgment Criteria (Refer to "Guiding Principles for Clinical Research of New Chinese Medicines for Traumatic Fractures") (1) Clinical cure: the clinical healing time of the drug is more than 1/3 earlier than that of similar fractures and reaches the clinical healing standard. (2) Significantly effective: the clinical application time is 1/3-1/4 earlier than the similar fracture healing time, and those who have reached the clinical healing standard. (3) Effective: The time of clinical application of the drug is 1/4 to 1/5 earlier than the healing time of similar fractures, and those who have reached the clinical healing standard. (4) Ineffective: The clinical medication time is the same as the normal healing time of similar fractures.

3.4 Judgment and analysis of curative effect After 12 weeks of treatment, 200 cases of the two groups were analyzed according to the 4-level curative effect judgment standard. After the X ² test, the curative effect of the upper, middle and lower decoction treatment groups was significantly better than that of the control group (P<0.01), and the difference was significant. very significant. See Table 3.

Table 3 Comparison of therapeutic effects between the two groups

in conclusion:

According to clinical experiments, the upper, middle and lower decoctions can significantly promote the growth of calluses, and the healing period is short, which can speed up the recovery of limb functions. During the clinical trials, no toxic and side effects occurred, and have the functions of promoting blood circulation, removing blood stasis, reducing swelling It has the effects of relieving pain, reconnecting tendons and bones, relaxing tendons and activating collaterals, and can promote fracture healing. It has a good curative effect on various fractures and bruises. At the same time, it also has a good curative effect on femoral head necrosis, osteoporosis and other parts of osteonecrosis.

Example 1:

For the upper, middle and lower parts of the soup, take the following raw materials according to the following weight ratio: frankincense: myrrh: Dipsacus: Chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster = 20:30:3: 30:30:25:35:35:25.

Its preparation method comprises the following steps:

1. First, the above-mentioned single herbs are selected, cleaned and dried, then pulverized with a pulverizer, and passed through a 100-mesh sieve;

2. Take the pulverized single herbs according to the above ratio and mix them thoroughly;

3. Boil the mixed medicine and water at a ratio of 1:10 over medium heat until the water volume is half of the original.

Example 2:

For the upper, middle and lower parts of the soup, take the following raw materials according to the following weight ratio: frankincense: myrrh: Dipsacus: Chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster=30:20:2: 20:20:15:25:25:15.

Its preparation method is with embodiment 1.

Example 3:

For the upper, middle and lower parts of the soup, take the following raw materials according to the following weight ratio: making frankincense: making myrrh: Dipsacus: Chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster=22:28:2.8: 28:28:23:32:32:23.

Its preparation method is with embodiment 1.

Example 4:

For the upper, middle and lower parts of the soup, take the following raw materials according to the following weight ratio: frankincense: myrrh: Dipsacus: Chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster=28:22:2.2: 22:22:17:27:27:17.

Example 5:

For the upper, middle and lower parts of soup, take the following raw materials according to the following weight ratio: frankincense: myrrh: Dipsacus: Rhizoma Chuanxiong: safflower: calcined keel: psoralen: Eucommia: oyster=25:25:2.5: 25:25:20:30:30:20.

Claims (4)

1. The decoction for treating fractures is characterized in that it is a medicament made from the raw materials of the following weight ratio: frankincense: myrrh: Dipsacus: Rhizoma Chuanxiong: safflower: calcined keel: psoralen: Eucommia: Oyster = 20-30: 20-30: 2-3: 20-30: 20-30: 15-25: 25-35: 25-35: 15-25. 2. The decoction for treating fractures according to claim 1, wherein the weight ratio of each raw material is frankincense: myrrh: Dipsacus: Chuanxiong: safflower: calcined keel: psoralen: Eucommia: Oyster = 22-28: 22-28: 2.2-2.8: 22-28: 22-28: 17-23: 27-32: 27-32: 17-23. 3. The decoction for treating fractures according to claim 1, wherein the weight ratio of each raw material is frankincense: myrrh: Dipsacus: Chuanxiong: safflower: calcined keel: psoralen: Eucommia: Oysters = 25:25:2.5:25:25:20:30:30:20. 4. The preparation method of the decoction for the treatment of fractures is characterized in that it is made of the raw materials of the following weight ratio: frankincense: myrrh: Dipsacus: Rhizoma Chuanxiong: safflower: calcined keel: psoralen: Eucommia: Oyster = 20-30: 20-30: 2-3: 20-30: 20-30: 15-25: 25-35: 25-35: 15-25; Its preparation method comprises the following steps: 1. Pulverize each of the above-mentioned single-flavor medicinal pulverizers and pass through a 100-mesh sieve; ②. Take the pulverized single herbs according to the above ratio and mix them thoroughly; ③. Boil the mixed medicine and water at a ratio of 1:10 over medium heat until the amount of water is half of the original.