CN103933154A - Traditional Chinese medicine composition for treating gout disease and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gout disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition formed by combining plant raw materials and used for treating gout disease and a preparation method of the composition. The traditional Chinese medicine composition comprises salvia miltiorrhiza, caulis spatholobi, radix achyranthis bidentatae, pawpaw and radix paeoniae alba. The traditional Chinese medicine composition for treating gout disease, which is disclosed by the invention, can be prepared into any common dosage form for oral administration, has a remarkable curative effect for treating and preventing gout disease, has a total effective rate of more than 100% for gout disease, and is good in effect after cure and free from relapse upon continuous tracking observation. According to the traditional Chinese medicine composition for treating gout disease, which is disclosed by the invention, by virtue of the mutual synergistic effect of medicine active ingredients in various Chinese herbal medicines, the great pain brought to people by illness is effectively eliminated, and the traditional Chinese medicine composition for treating gout disease is free from any toxic and side effects, short in medication treatment course time, fast to become effective and free from relapse, and achieves the purpose of radical treatment.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of auxiliary treatment gout, uric acid and methyl guanine and the too high symptom of adenine and preparation method thereof.
Background technology
Gout claims again hyperuricemia, to cause purine metabolism obstacle and blood uric acid to continue the disease that raises and cause by heritability or the acquired cause of disease, its sickness rate is high, healing is difficult, outbreak repeatedly, belong to the metabolic disease that purine metabolism obstacle causes, in human body, the metabolism of the material of purine gets muddled, the synthetic increase of uric acid or discharge reduce, cause hyperuricemia, when serum Uric Acid Concentration is too high, uric acid is deposited in joint, cartilage and kidney with the form of sodium salt, causes and organizes foreign body inflammatory reaction.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker.Gout can be accustomed to by dietetic life, and Changes in weather is suddenlyd change as temperature and air pressure, and medicine, wound etc. are many-sided to be caused.Slight wound, the high purine food of gluttony or excessive drinking, operation, fatigue, nervous, internal medicine acute disease (as infected, angiemphraxis) all can bring out gout acute attack.Be everlasting acute simple joint or the normally onset symptoms of multi-joint pain of night-time attack.
Along with the raising of people's living standard, the change of dietary structure, the sickness rate of gout has the trend increasing year by year, the domestic different regions of research report prevalence of gout was difference, be about 0.0352%-1.33%, prevalence of hyperuricemia is up to 2.44%-13.3%, and in hyperuricemia, the prevalence of gout is 3.1%.The ill age occurred frequently is in 45-65 year.Male's prevalence of gout was is about 2-3 times of women's prevalence, and before 60 years old, male falls ill higher than women, and women's morbidity was common in after menopause.Gout is found in each age group, but between age groups, has obvious difference, and primary gout is more common in middle age, accounts for more than 90%; In child and old gout, secondary gout sickness rate higher [4].The generation of gout is often with various diseases, and as obesity, hyperlipidemia, hypertension, coronary heart disease, diabetes etc., serious harm patient's physical and mental health and life security thereof, cause heavy disease burden to patient family and society.
Goat increases reason according to uric acid in blood and is divided into constitutional and the large class of Secondary cases two.The cause of disease of primary gout is due to due to congenital purine metabolic disturbance, belongs to heritability.The cause of disease of secondary gout, can be caused by many reasons such as nephropathy, leukemia, medicine, foods, is apt to occur in male and menopausal woman.Its clinical manifestation is that carrying out property of pain increases the weight of, and is severe pain.Sign is similar to actute infection, has swelling, local pyrexia, red and obvious tenderness etc.Local skin anxiety, heating, glossy, outward appearance is kermesinus or aubergine.The metatarsophalangeal joints of hallux toe involves the most common (podagra), arch of foot, and ankle joint, knee joint, carpal joint and elbow joint etc. is also common site of pathological change.Whole body performance comprises heating, cardiopalmus, shiver with cold, discomfort and leukocytosis.Often involve kidney and cause that chronic interstitial nephritis and uric acid renal calculus form.
Gout is chronic disease, and acute attack stage and catabasis alternate to occur it being the large feature of primary disease one.Modern medicine there is no specially good effect prophylactico-therapeutic measures to this disease at present, and Drug therapy is mainly carry out symptomatic treatment and reduce uric acid and treating according to the state of an illness.Modern medicine is to the treatment of goat generally by acute stage, intermission and chronic phase treatment, and wherein, acute stages treated is mainly the outbreak that stops quickly and effectively acute arthritis, reduces the generation of uric acid, promotes urate excretion; Intermittent and chronic phase treatment is mainly the level of controlling blood uric acid, the internal organs that protection has come to harm.The medicine that is used for the treatment of at present gout mainly contains: colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen (naproxen congex), ACTH and prednisone etc.Above-mentioned these medicines all have defect, mostly can only stablize the state of an illness, can not effect a radical cure gout; Also can cause that serious side effect causes the infringement of hepatic and renal function; Even if Emergent therapy effectively can not be controlled disease relapse, and can produce drug resistance and repellence, even there will be leukopenia, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause the complication such as diabetes, and gout has the feature of outbreak repeatedly, patient is difficult to accept long-term taking Western medicine.。
The medicine safely and effectively of finding treatment goat from Chinese medicine approach and the trend for the treatment of goat of can yet be regarded as, meets the needs of clinical diagnosis and treatment.According to medical research, the pathogenic factor of goat be mainly cause because the metabolism of human liver renal function is not normal uric acid, blood urea nitrogen, methyl guanine and adenine in blood too high due to.Chinese medicine thinks that this disease is because hepatic and renal function goes down, due to metabolism is unfavorable.Body endogenous dampness pathogenic heat poison gathers, due to superfluous and raw wind.Therefore, research meets disease, the cause of disease, the pathogenesis of Chinese medical theory and goat, finds the medicine of suitable treatment gout, has larger research and development and is worth.
Summary of the invention
Primary and foremost purpose of the present invention is to provide a kind of Chinese medicine composition with treatment goat and preparation method thereof for the problems referred to above.The disease that the compositions with treatment goat of the present invention causes due to the material object that hepatic and renal function goes down, metabolism is not normal and diet purine-containing is too high for human body, utilize the mutual synergism of the active constituents of medicine in multiple Chinese herbal medicine, the great pain that efficient solution brings except slight illness, and without any side effects.
For realizing object of the present invention, one aspect of the present invention provides a kind of pharmaceutical composition for the treatment of goat, comprises following raw material: Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis, the Radix Paeoniae Alba.
Wherein, the weight portion proportioning of the raw material of the pharmaceutical composition of described treatment goat is: Radix Salviae Miltiorrhizae 15 ?50, Caulis Spatholobi 10 ?35, Radix Achyranthis Bidentatae 1 ?25, Fructus Chaenomelis 1 ?20, the Radix Paeoniae Alba 10 ?50.
Particularly, the weight portion proportion optimization of described crude drug is: Radix Salviae Miltiorrhizae 25 ?40, Caulis Spatholobi 20 ?30, Radix Achyranthis Bidentatae 5 ?15, Fructus Chaenomelis 5 ?15, the Radix Paeoniae Alba 20 ?40.
Especially, the weight portion proportioning of described crude drug is: Radix Salviae Miltiorrhizae 30, Caulis Spatholobi 20, Radix Achyranthis Bidentatae 10, Fructus Chaenomelis 10, the Radix Paeoniae Alba 30.
The pharmaceutical composition for the treatment of goat of the present invention is based on Chinese medicine, the pathogenetic of goat to be fully realized, in conjunction with the achievement of modern pharmacy and pharmaceutical research, select Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis, the Radix Paeoniae Alba to carry out scientific composition and be prepared from, taking the Chinese crude drug of pure natural as raw material, have no side effect, it reaches the object for the treatment of and prevention goat by the effect of blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral and heat-clearing and toxic substances removing.
Wherein: Radix Salviae Miltiorrhizae is cold in nature, bitter in the mouth, GUIXIN, Liver Channel.There is blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, effect of the pain pain relieving that disappears, be mainly used in treating that angina pectoris, menoxenia, dysmenorrhea, WEIJIA are gathered, breast ventral spine pain, pyretic arthralgia pain, hepatosplenomegaly.The chemical composition of Radix Salviae Miltiorrhizae mainly contains TANSHINONES and danshensu, has antitumor, resists myocardial ischemia, anti-heart infarction, anticoagulation, activation fibrinolytic, stablizes erythrocyte membrane, anti-liver pulmonary fibrosis, antiinflammatory, antibacterial, antiulcer and resisting oxygen lack.Prove according to experimentation, Radix Salviae Miltiorrhizae can obviously reduce the serum-concentration of blood urea nitrogen, creatinine methylguanidine, guanidine radicals succinic acid, has both improved hyperphosphatemia, has improved again the crystal formation of blood Free Amino Acids, effectively promotes graft function.
Caulis Spatholobi, warm in nature, sweet in the mouth, hardship, return liver, kidney channel.Have enrich blood, invigorate blood circulation, effect of channels sootheing and network vessel quickening, be mainly used in treating that rheumatism numbness is logical, soreness of waist and knee joint, paralysis and numbness, menoxenia, blood deficiency and yellow complexion and swell and ache etc.,
The chemical composition of Caulis Spatholobi mainly contains isoflavone and phenolic compound, steroidal and glucosides thereof.Modern pharmacological research shows that Caulis Spatholobi has blood circulation promoting and blood stasis dispelling, blood circulation promoting, the liver and the kidney tonifying, nourishes blood and enrich blood, improve the effect of immunity and antiinflammatory.Show according to zoopery: the dirty total phosphorus metabolism of Caulis Spatholobi dialogue Ren Mus and anabolism play a driving role.This product still has decorporation to let out chloride and increases urate excretion, the effect of gout, and effective to treatment edema.
Radix Achyranthis Bidentatae, property is flat, and sour in the mouth, hardship, return liver, kidney channel.There is invigorating the liver and kidney, promoting blood circulation to restore menstrual flow, clearing away heat from blood, the effect descending, relieving stranguria by diuresis of igniting, be mainly used in that Zhi Liao WEIJIA is gathered, soreness of waist and knee joint, stranguria edema, dysuria, traumatic injury, the stagnant pain of the stasis of blood, top are burning hot, amenorrhea dysmenorrhea etc.
The chemical composition of Radix Achyranthis Bidentatae mainly contains triterpenes, steroid, polysaccharide and alkaloids and trace elements iron, zinc, copper, manganese, cobalt etc., has anti-inflammatory and antalgic and improves the effect of hepatic and renal function.Modern pharmacological research shows: Radix Achyranthis Bidentatae is containing insectean metamorphosis steroid hormone, there is stronger protein synthesis facilitation, give after the oral inokosterone of mice, the amount of finding aminoacid synthetic protein in liver significantly increases, its effect is similar to strong protein anabolic hormone 4-chlorotestosterone effect, has protein assimilation.
Fructus Chaenomelis, warm in nature, sour in the mouth, puckery, returns liver, spleen channel.There is suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness, bone and muscle strengthening, sharp joint, wind-damp dispelling, be mainly used in treating that waist lower limb is tingle, beriberi edema, twitch convulsion, rheumatic arthralgia.
The chemical composition of Fructus Chaenomelis mainly contains acid compounds, saponin, flavonoid, vitamin C etc.Have hepatoprotective, improve immunity, spasmolytic and antiinflammatory action, show according to modern pharmacological research: the contained malic acid of Fructus Chaenomelis can be alleviated extremity spasm, particularly gastrointestinal smooth muscle and sura smooth muscle.Fructus Chaenomelis Chinesis decoct 35
g/ k
ggive mouse stomach, albumen arthritis is had to certain detumescence effect.
The Radix Paeoniae Alba, cold nature, bitter in the mouth, acid, return liver, spleen channel.Have nourishing YIN and benefiting blood, suppressing the hyperactive liver pain relieving, antibacterial anti-effect swelling and ache, is mainly used in treating blood deficiency and yellow complexion, fever due to yin deficiency, extremity spasm, dizziness headache, menoxenia, aching pain of muscles etc.
The chemical composition of the Radix Paeoniae Alba mainly contains medicine glycoside, benzoic acid, the cupreols such as Radix Paeoniae phenol and contains volatile oil, fatty wet goods, has antiinflammatory, antibacterial, antiviral, anoxia enduring, solution spasm, protects the liver kidney and strengthen immune effect.Modern pharmacological research shows: the Radix Paeoniae Alba all has certain inhibitory action to staphylococcus, A type and beta hemolytic streptococcus, Diplococcus pneumoniae, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus.Radix Paeoniae Alba extract is swollen to rat Ovum Gallus domesticus album acute inflammation edema, cotton balls internal bud, adjuvant-induced arthritis has significant inhibition and preventive and therapeutic effect, thereby shows that Radix Paeoniae Alba total glucosides has certain antiinflammatory and immunoregulation effect.
The present invention provides a kind of preparation method of compositions of the Chinese medicine of stating treatment goat on the other hand, comprises the steps:
1) prepare raw material according to following weight portion proportioning:
Radix Salviae Miltiorrhizae 15 ?50, Caulis Spatholobi 10 ?35, Radix Achyranthis Bidentatae 1 ?25, Fructus Chaenomelis 1 ?20, the Radix Paeoniae Alba 10 ?50;
2) by after described crude drug Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis mix homogeneously, mixed material medicine is carried out to heating extraction, collect extracting solution;
3) to collect extracting solution carry out concentration, make Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis concentrated solution;
4) the crude drug Radix Paeoniae Alba is carried out to pulverization process, make granularity and be less than 200 object Radix Paeoniae Alba fine powders;
5) Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis concentrated solution mix homogeneously and get final product with Radix Paeoniae Alba fine powder.
Wherein, step 1) described in the weight portion proportion optimization of crude drug be: Radix Salviae Miltiorrhizae 25 ?40, Caulis Spatholobi 20 ?30, Radix Achyranthis Bidentatae 5 ?15, Fructus Chaenomelis 5 ?15, the Radix Paeoniae Alba 20 ?40, be preferably Radix Salviae Miltiorrhizae 30, Caulis Spatholobi 20, Radix Achyranthis Bidentatae 10, Fructus Chaenomelis 10, the Radix Paeoniae Alba 30.
Wherein, step 2) described in heating extraction comprise as follows step in sequence:
A) mixture is added to water soaking, the weight of the water adding is 6 ?10:1 with the ratio of the weight of mixture, soaks 1 ?and after 3 hours, carries out heating extraction for the first time, and heating-up temperature is 100 DEG C, is to extract 1 ?3 hours under the condition of 100 DEG C keeping temperature;
B) extracting solution filters for the first time, collects filtrate;
C) in filtering residue, add water, carry out heating extraction for the second time, wherein, the weight of the water adding and the ratio of the weight of mixture be 5 ?10:1, heating-up temperature is 100 DEG C, keep temperature be under the condition of 100 DEG C, extract 1 ?3 hours;
D) filter, the filtrate of twice filtration is merged.
Particularly, steps A) described in heating extraction time 1.5 ?2.5 hours, the weight of the water adding and the ratio of the weight of mixture be preferably 7 ?8:1; Step C) in the ratio of the weight of water that adds and the weight of mixture be 5 ?7:1.
Wherein, step 3) described in filtrate concentration process in control temperature be 80 ?100 DEG C, relative pressure Di Yu ?0.05MPa.
Particularly, described relative pressure You Xuan Wei ?0.05～?0.095MPa.
Particularly, step 3) described in the weight of concentrated solution and the ratio of the gross weight of crude drug Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis be 0.5 ?0.85:1, be preferably 0.6 ?0.8:1, more preferably 0.7:1.
Wherein, the granularity of the fine powder of the Radix Paeoniae Alba described in step 4 is less than 100 orders, be preferably and be less than 200 orders, more preferably 200 ?300 orders.
Particularly, also comprise step 6) to Dan Can ?Ji Xue Teng ?Niu Xi ?add pharmaceutically acceptable adjuvant in Fructus Chaenomelis concentrated solution and Radix Paeoniae Alba fine powder mixture, mix.
Particularly, add after food preservative mix homogeneously, adding appropriate distilled water, be placed in pellet processing machine and make pill.
Particularly, add after adjuvant dextrin and food preservative mix homogeneously, adding appropriate distilled water, be placed in pellet processing machine and make pill.
Especially, the compositions after described dried and the weight proportion of dextrin are 10:100; Compositions after described dried is 100:0.05 with the ratio of the weight of food preservative.
Particularly, described food preservative is selected potassium sorbate, sodium diacetate, benzoic acid and salt, calcium propionate, sodium lactate or dehydro sodium acetate.
Wherein, described pharmaceutically acceptable carrier is used for this purpose and the non-active ingredient as medicament by sanitarian's accreditation conventionally.About pharmaceutically acceptable carrier compilation can in " handbook of pharmaceutical excipients ", (Handbook of Pharmaceutical excipients,, be edited by A.Wade and P.J.Weller by the 2nd edition; American Pharmaceutical Association publishes, Washington and The Pharmaceutical Press, London, 1994) etc. find in reference book.
Particularly, described carrier comprises excipient, as starch, water etc.; Lubricant, as magnesium stearate etc.; Disintegrating agent, as microcrystalline Cellulose etc.; Filler, as lactose etc.; Binding agent, as pregelatinized Starch, dextrin etc.; Sweeting agent; Antioxidant; Antiseptic, correctives, spice etc.
The active component of medicine of the present invention can add various conventional adjuvant required while preparing different dosage form, as disintegrating agent, lubricant, adhesive etc. are prepared into any conventional peroral dosage form with conventional method of Chinese medicinal, as pill, powder, tablet, granule, capsule, oral liquid etc.
The compositions for the treatment of goat of the present invention is according to Chinese medicine the liver and the kidney tonifying, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, expelling wind and removing dampness, suit the remedy to the case, treating both the principal and secondary aspects of a disease the theoretical and special role compatibility of human body being formed according to the public and chemical composition of above medicine, reaches the object of the liver and the kidney tonifying, nourshing blood and promoting blood circulation, expelling wind and removing dampness, diuresis toxin expelling, relieving spasm to stop pain, raising immunity and metabolic function with Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, the Radix Paeoniae Alba, the mutual synergism of Fructus Chaenomelis.The Chinese medicine composition for the treatment of goat of the present invention is applicable to local muscle swelling, joint deformity, and twinge, migratory pain, uric acid is too high.
We are taking Radix Salviae Miltiorrhizae, Caulis Spatholobi two medicines as monarch, and two medicines are harmonious, and have the merit of clearing heat and expelling damp removing toxic substances.Taking Radix Achyranthis Bidentatae as ministerial drug, both principal drug assistance damp eliminating thermal detoxifications, principal drug assistance the meridian dredging pain relieving again, the monarch and his subjects obtain mutually, the common gram of merit of fainting.Fructus Chaenomelis, the Radix Paeoniae Alba are adjuvant.Above-mentioned five medicines are harmonious, and play altogether clearing away heat-damp and promoting diuresis, and the merit of removing obstruction in the collateral to relieve pain, makes diarrhea due to damp-heat and wind removes, and through ruton and numbness solution, all cards are from removing.
According to the pharmacological evaluation with treatment goat compositions of the present invention is proved, treatment goat compositions of the present invention not only the drug treatment time short, instant effect, without recurrence, and safe without toxic side effect.
Detailed description of the invention
In order to confirm curative effect and the safety in utilization of pharmaceutical composition of the present invention, inventor has carried out pharmacodynamics and toxicity test is investigated, and test method and result of the test are as follows:
The impact of test example 1 on hyperuricemia Mouse Blood uric acid level
1, test material
1.1 animal
Wister rat, male, body weight 180 ?220g, by being provided by dimension tonneau China's zoopery center.
1.2 medicines and reagent
Medicine of the present invention be the Dan Can that makes according to crude drug weight proportion described in embodiment 1 and method ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture.
By Dan Can ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture add water, make suspension, for subsequent use.
Positive control drug: colchicine (Banna Pharmacy Industry Co., Ltd., Xishuangbanna, lot number: 120204; Specification: 0.5mg*20s).
Colchicine is dissolved in water, makes the solution that concentration is 6g/ml, for subsequent use.
Reagent: adenine, ethambutol sheet, blood uric acid test kits
1.3 instrument
Purple outer ?visible spectrophotometer: UV ?5100 (Shanghai Yuan Xi Instrument Ltd.)
2, test method and result
2.1 test method
60 male rats are divided into 6 groups at random, 10 every group: blank group, model group, positive drug matched group, the high, medium and low dosage group of the present invention (10g raw medicinal herbs/kg, 5g raw medicinal herbs/kg, 2.5g raw medicinal herbs/kg).Except blank group, all the other are respectively organized all with adenine (100mgkg-1), the modeling of ethambutol sheet (100mgkg-1) gavage; Blank group gavage equivalent distilled water, every day 1 time, continuous 7 days.All the other respectively organize rats simultaneously according to the dosage gastric infusion of table 1, blank group, model group gavage equivalent distilled water, every day 1 time, continuous 7 days.Each group rat diet drinking-water is not limit.In experiment the 8th day, respectively organize rat heart and get blood, centrifugal (3000rpm, 15min), separation of serum, by the operation of blood uric acid test kit description, measures the content of uric acid in serum.
2.2 result of the test
Result of the test is as shown in table 1.
The impact of table 1 on rat hyperuricemia serum uric acid (
)
Result shows, model group is compared with blank group, and the Level of Serum Uric Acid of the two has significant diversity, shows that the mixed liquor of this test gavage adenine and Assay for Ethambutol hydrochloride in Ethambutol hydrochloride Tablets can cause rat hyperuricemia model, modeling success; The present invention prepares the high, medium and low dosage of Chinese medicine composition for the treatment of goat can obviously suppress extremely increasing of hyperuricemia rat model uric acid in serum, shows that the Chinese medicine composition for the treatment of goat prepared by the present invention has good therapeutical effect to rat hyperuricemia.
The impact of test example 2 Dichlorodiphenyl Acetate induced mice writhing responses
1, test material
1.1 animal
Kunming mouse, male and female half and half, body weight 18 ?22g, provided by dimension tonneau China's zoopery center.
1.2 medicines and reagent
Medicine of the present invention be the Dan Can that makes according to crude drug weight proportion described in embodiment 1 and method ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture.
By Dan Can ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture add water, make suspension, for subsequent use.
Positive control drug: colchicine (Banna Pharmacy Industry Co., Ltd., Xishuangbanna, lot number: 120204; Specification: 0.5mg*20s).
Colchicine is dissolved in water, makes the solution that concentration is 6g/ml, for subsequent use.
Reagent: 0.6% acetum
2, test method and result
2.1 test method
Get 50 of mices, male and female half and half, are divided into 5 groups at random, and 10 every group, i.e. blank group, positive drug matched group, the high, medium and low dosage group of the present invention (10g raw medicinal herbs/kg, 5g raw medicinal herbs/kg, 2.5g raw medicinal herbs/kg).Gastric infusion dosage is 20ml/kg, blank group gavage gives the normal saline of same volume, administration every day 1 time, successive administration 5 days, 1h after last administration, 0.6% of preparation acetum before every group of mouse peritoneal injection experiment, observes immediately mice and occurs first mouse writhing frequency in incubation period and 15 minutes of writhing response.
2.2 result of the test
Result of the test is as shown in table 2.
The impact of table 2 on writhing response due to mice acetic acid (
)
| Group | Dosage | Writhing incubation period (s) | Writhing (inferior) |
| Blank group | Equal-volume | 135.45±45.21 | 35.6±3.7 |
| Positive drug matched group | 20ml/kg | 238.56±51.02 | 16.7±8.1 |
| High dose group of the present invention | 10g raw medicinal herbs/kg | 243.27±39.78 | 15.4±5.7 |
| Dosage group in the present invention | 5g raw medicinal herbs/kg | 226.37±49.23 | 16.1±6.2 |
| Low dose group of the present invention | 2.5g raw medicinal herbs/kg | 210.81±42.36 | 18.9±5.2 |
Result of the test shows: the present invention prepares the high, medium and low dosage of Chinese medicine composition for the treatment of goat and can obviously extend mice and occur first the incubation period of writhing, reduces mouse writhing number of times, has significant diversity compared with blank group.There is obvious paroxysmal pain effect to mice acetic acid is pain caused.
Test example 3 clinical trials
1, object of study
Choose tested case 200 examples of year July in April, 2010 to 2013 in Dongzhimen Affiliated Hospital of Beijing University of Chinese Medicine, adopt parallel control, random method for designing, be divided at random 2 groups (treatment group, matched groups), every group of 100 examples, wherein male's 91 examples in treatment group, women's 9 examples; Male's 92 examples in matched group, women's 8 examples.
2, case selection
Gout is that purine metabolic disturbance causes uric acid to synthesize the metabolic disease increasing and cause.Often show as big toe, foot area (dorsal portion, heel and ankle), joint, subcutaneous, extremity or body part muscle swelling, twinge unbearably, even stiff, severe patient whole-body muscle or arthroncus severe pain.When gout outbreak, show as the serious pain in the joint of getting involved, swelling, erythema, stiff, heating, and symptom occurs suddenly.Stage of attack, generally continued a couple of days by 1 week, but along with the increasing the weight of of disease, periarticular destruction can show as " damaged by rats " sample damage in classical bilateral joint.
1 times of above (normal reference value of serum uric acid: male 149-416 μ mol/L of goat patient's uric acid in serum horizontal exceeding normal value; Women: 89 ?257 μ mol/L), in serum, methyl guanine, adenine and hydroxyadenine can be detected.
3, Therapeutic Method
All cases, during treating, all require diet control, and participate in suitable physical training.The treatment group precious health ball of herbal gout that all prepared by the oral embodiment of the present invention 1, takes medicine 3 times for each person every day, the dosage of each 5g, and take half an hour ante cibum; Matched group is taken allopurinol tablet (Beijing You Hua pharmaceutcal corporation, Ltd, every 100mg, 100 slices/bottle), and every day 2 times, each 100mg, take one month continuously.
Treatment group, matched group are all withdrawn other class anti-gout drugs at experimental session simultaneously.
Patient regularly follows up a case by regular visits at special outpatient clinic weekly, carries out clinical observation.Before and after treatment, detect respectively uric acid in serum content and purine, after treatment finishes, check 1 time.
4, criterion of therapeutical effect
Efficacy assessment standard: 1. effective: after treatment, symptom disappears substantially, and serum uric acid reaches normal value, does not detect methyl guanine, adenine and hydroxyadenine in serum; 2. effective: after treatment, symptom is obviously improved, serum uric acid reduces, but does not reach normal value, does not detect methyl guanine, adenine and hydroxyadenine in serum; 3. invalid: after treatment, symptom is not improved, serum uric acid declines, but does not reach normal level; In serum, can also detect purine.
5, experimental result and analysis
Table 3 the present invention treats the compositions of gout to the therapeutic effect of goat
| ? | Treatment group | Matched group |
| Experimenter's quantity (example) | 100 | 100 |
| Effective (example) | 91 | 89 |
| Effectively (example) | 7 | 9 |
| Invalid (example) | 2 | 2 |
| Aggregate efficiency (%) | 98.0 | 98.0 |
Result of the test shows: take continuously after the Chinese medicine composition for the treatment of goat of the present invention, the uric acid in patients serum and purine value significantly decline, and shows that Chinese medicine composition of the present invention has better therapeutic effect to goat patient; .
After 98% patient takes medicine 1 day, pain is alleviated to some extent, and after three days, symptom is obviously alleviated, and after one week, alleviates substantially completely, can be freely movable, and after 2 weeks, all symptoms all disappear, and check that uric acid and purine thing all reach normal level.Diet recovers afterwards normal and no case was recurrence.Only 2% severe patient because of sick time long, health pain point is many, and after multi-medicament is failed to respond to any medical treatment, take operative treatment but not controlled yet, through take treatment goat compositions of the present invention after ten days symptom start alleviate, check that uric acid and purine thing start to decline, after 20 days, remission is more than 60%; After 30 days, symptom is alleviated substantially completely, all disappears to all symptoms after 45 days, and it is normal that diet recovers, and checks that uric acid and purine thing all reach normal level.Through continuous half a year tracing observation still without recurrence, effective percentage 100%, and reached the object of effecting a radical cure.In treatment goat compositions of the present invention, there is the health-care effect of prevention goat, and have no side effect.
Test example 4 the present invention treat goat compositions toxicological test
(1) acute toxicity test
Treatment goat compositions pill of the present invention is gavaged to 1000g (crude drug)/kg to kunming mice.Do not occur any toxic reaction, one week interior without animal dead.
(2) long term toxicity test
Treatment goat compositions pill of the present invention is carried out to long term toxicity test to rat, continuously heavy dose of (adult's dosage 100 times) gastric infusion, administration time long (90 days), taking general performance, body weight, food ration, hematology and Biochemical Indices In Serum before and after animals administer, routine urinalysis, bone marrow classification, organ weights, organ coefficient as detecting index, and be aided with animal and respectively organize the pathological examination of internal organs, the toxicity situation of overall merit medicine.Result shows that the indices of rat is all normal.Histopathologic examination's result demonstration, rat is respectively organized internal organs no abnormality seen.
In sum: treatment goat compositions toxicity of the present invention is low, and safety range is wide, and it is reliable that the present invention treats goat compositions edible safety.
Further illustrate by the following examples the preparation method of the present composition.
Embodiment 1 present composition pill preparation
1) take raw material (unit: × 10g) according to following proportioning
Radix Salviae Miltiorrhizae 30, Caulis Spatholobi 20, Radix Achyranthis Bidentatae 10, Fructus Chaenomelis 10, the Radix Paeoniae Alba 30
2) by after medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis rinsing, be placed in Multifunctional Chinese medicine and extract still mix homogeneously, add tap water to soak 2 hours, wherein, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 8:1;
3) open multi-functional extraction still power supply and heat, be heated to 100 DEG C, remain at this temperature constant temperature and extract 2 hours, then filter, obtain that extracting solution is for subsequent use for the first time;
4) in filtering residue, add tap water, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 6:1, heating extraction, and keeping heating-up temperature is at 100 DEG C, to extract 1.5 hours, filters and obtains extracting solution for the second time;
5) 2 extracting solution merging are placed in vacuum high energy evaporation concentrator and carry out concentrating under reduced pressure, make Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid, wherein, the relative pressure Wei of concentrating under reduced pressure ?0.07MPa (taking an atmospheric pressure as 0, control pressure when concentrating under reduced pressure with respect to atmospheric pressure Wei ?0.07MPa), be heated to 80 DEG C, the weight of mixed concentrated liquid and medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, the ratio of the weight of Fructus Chaenomelis 4 taste crude drug mixture is 0.7:1, be evaporated to Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, 70% of Fructus Chaenomelis 4 taste crude drug in whole weight,
6) the crude drug Radix Paeoniae Alba is placed in to pulverizer and pulverizes and sieve processing, make granularity and be less than 200 object Radix Paeoniae Alba fine powders;
7) by Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid mix with Radix Paeoniae Alba fine powder, and stir, make Dan Can ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture, then pill in pellet processing machine, is drying to obtain the precious health ball of compositions book on Chinese herbal medicine gout for the treatment of goat of the present invention.
By taking for each person every day 3 times, each 5g, under-18s reduces by half, and within 10 days, is a course for the treatment of.
Embodiment 2 present composition granule preparations
1) take raw material (unit: × 10g) according to following proportioning
Radix Salviae Miltiorrhizae 25, Caulis Spatholobi 30, Radix Achyranthis Bidentatae 15, Fructus Chaenomelis 5, the Radix Paeoniae Alba 40
2) by after medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis rinsing, be placed in Multifunctional Chinese medicine and extract still mix homogeneously, add tap water to soak 2 hours, wherein, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 7:1;
3) open multi-functional extraction still power supply and heat, be heated to 100 DEG C, remain at this temperature constant temperature and extract 2 hours, then filter, obtain that extracting solution is for subsequent use for the first time;
4) in filtering residue, add tap water, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 7:1, heating extraction, and keeping heating-up temperature is at 100 DEG C, to extract 1.5 hours, filters and obtains extracting solution for the second time;
5) 2 extracting solution merging are placed in vacuum high energy evaporation concentrator and carry out concentrating under reduced pressure, make Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid, wherein, the relative pressure Wei of concentrating under reduced pressure ?0.05MPa (taking an atmospheric pressure as 0, control pressure when concentrating under reduced pressure with respect to atmospheric pressure Wei ?0.05MPa), be heated to 100 DEG C, the weight of mixed concentrated liquid and medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, the ratio of the weight of Fructus Chaenomelis 4 taste crude drug mixture is 0.6:1, be evaporated to Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, 60% of Fructus Chaenomelis 4 taste crude drug in whole weight,
6) the crude drug Radix Paeoniae Alba is placed in to pulverizer and pulverizes and sieve processing, make granularity and be less than 300 object Radix Paeoniae Alba fine powders;
7) by Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid mix with Radix Paeoniae Alba fine powder, and stir, make Dan Can ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture, then add pharmaceutically acceptable adjuvant (as microcrystalline Cellulose, consumption 10%) and food preservative (as potassium sorbate, consumption is 0.05%), after mix homogeneously, in granulation, obtain the precious recovering particles of compositions book on Chinese herbal medicine gout for the treatment of goat of the present invention.
Embodiment 3 present composition pill preparations
1) take raw material (unit: × 10g) according to following proportioning
Radix Salviae Miltiorrhizae 40, Caulis Spatholobi 20, Radix Achyranthis Bidentatae 5, Fructus Chaenomelis 15, the Radix Paeoniae Alba 20
2) by after medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis rinsing, be placed in Multifunctional Chinese medicine and extract still mix homogeneously, add tap water to soak 2 hours, wherein, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 8:1;
3) open multi-functional extraction still power supply and heat, be heated to 100 DEG C, remain at this temperature constant temperature and extract 2 hours, then filter, obtain that extracting solution is for subsequent use for the first time;
4) in filtering residue, add tap water, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 5:1, heating extraction, and keeping heating-up temperature is at 100 DEG C, to extract 1.5 hours, filters and obtains extracting solution for the second time;
5) 2 extracting solution merging are placed in vacuum high energy evaporation concentrator and carry out concentrating under reduced pressure, make Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid, wherein, the relative pressure Wei of concentrating under reduced pressure ?0.095MPa (taking an atmospheric pressure as 0, control pressure when concentrating under reduced pressure with respect to atmospheric pressure Wei ?0.095MPa), be heated to 90 DEG C, the weight of mixed concentrated liquid and medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, the ratio of the weight of Fructus Chaenomelis 4 taste crude drug mixture is 0.8:1, be evaporated to Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, 80% of Fructus Chaenomelis 4 taste crude drug in whole weight,
6) the crude drug Radix Paeoniae Alba is placed in to pulverizer and pulverizes and sieve processing, make granularity and be less than 100 object Radix Paeoniae Alba fine powders;
7) by Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid mix with Radix Paeoniae Alba fine powder, and stir, make Dan Can ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture, then add pharmaceutically acceptable adjuvant (as potassium sorbate, consumption is 0.05%), after mix homogeneously in pellet processing machine pill, obtain the precious health ball of compositions book on Chinese herbal medicine gout for the treatment of goat of the present invention.
Embodiment 4 present composition capsule preparations
1) take raw material (unit: × 10g) according to following proportioning
Radix Salviae Miltiorrhizae 15, Caulis Spatholobi 35, Radix Achyranthis Bidentatae 1, Fructus Chaenomelis 20, the Radix Paeoniae Alba 10
2) by after medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis rinsing, be placed in Multifunctional Chinese medicine and extract still mix homogeneously, add tap water to soak 1 hour, wherein, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 10:1;
3) open multi-functional extraction still power supply and heat, be heated to 100 DEG C, remain at this temperature constant temperature and extract 3 hours, then filter, obtain that extracting solution is for subsequent use for the first time;
4) in filtering residue, add tap water, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 5:1, heating extraction, and keeping heating-up temperature is at 100 DEG C, to extract 3 hours, filters and obtains extracting solution for the second time;
5) 2 extracting solution merging are placed in vacuum high energy evaporation concentrator and carry out concentrating under reduced pressure, make Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid, wherein, the relative pressure Wei of concentrating under reduced pressure ?0.07MPa (taking an atmospheric pressure as 0, control pressure when concentrating under reduced pressure with respect to atmospheric pressure Wei ?0.07MPa), be heated to 90 DEG C, the weight of mixed concentrated liquid and medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, the ratio of the weight of Fructus Chaenomelis 4 taste crude drug mixture is 0.85:1, be evaporated to Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, 85% of Fructus Chaenomelis 4 taste crude drug in whole weight,
6) the crude drug Radix Paeoniae Alba is placed in to pulverizer and pulverizes and sieve processing, make granularity and be less than 200 object Radix Paeoniae Alba fine powders;
7) by Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid mix with Radix Paeoniae Alba fine powder, and stir, make Dan Can ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture, (as microcrystalline Cellulose, consumption is 10% then to add pharmaceutically acceptable adjuvant; Potassium sorbate preservative, consumption 0.5%), after mix homogeneously, be dried, in incapsulating, obtain the precious recovering capsule of compositions book on Chinese herbal medicine gout for the treatment of goat of the present invention.
Embodiment 5 present composition pill preparations
1) take raw material (unit: × 10g) according to following proportioning
Radix Salviae Miltiorrhizae 50, Caulis Spatholobi 10, Radix Achyranthis Bidentatae 25, Fructus Chaenomelis 1, the Radix Paeoniae Alba 50
2) by after medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis rinsing, be placed in Multifunctional Chinese medicine and extract still mix homogeneously, add tap water to soak 3 hours, wherein, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 6:1;
3) open multi-functional extraction still power supply and heat, be heated to 100 DEG C, remain at this temperature constant temperature and extract 1 hour, then filter, obtain that extracting solution is for subsequent use for the first time;
4) in filtering residue, add tap water, the ratio of the weight (dry weight) of the weight of the tap water adding and medical material mixture is 10:1, heating extraction, and keeping heating-up temperature is at 100 DEG C, to extract 1 hour, filters and obtains extracting solution for the second time;
5) 2 extracting solution merging are placed in vacuum high energy evaporation concentrator and carry out concentrating under reduced pressure, make Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid, wherein, the relative pressure Wei of concentrating under reduced pressure ?0.07MPa (taking an atmospheric pressure as 0, control pressure when concentrating under reduced pressure with respect to atmospheric pressure Wei ?0.07MPa), be heated to 90 DEG C, the weight of mixed concentrated liquid and medical material Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, the ratio of the weight of Fructus Chaenomelis 4 taste crude drug mixture is 0.5:1, be evaporated to Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, 50% of Fructus Chaenomelis 4 taste crude drug in whole weight,
6) the crude drug Radix Paeoniae Alba is placed in to pulverizer and pulverizes and sieve processing, make granularity and be less than 200 object Radix Paeoniae Alba fine powders;
7) by Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis mixed concentrated liquid mix with Radix Paeoniae Alba fine powder, and stir, make Dan Can ?Ji Xue Teng ?Niu Xi ?Mu Gua ?Radix Paeoniae Alba mixture, then add pharmaceutically acceptable adjuvant (potassium sorbate preservative, consumption is 0.05%), after mix homogeneously in pellet processing machine pill, obtain the precious health ball of compositions book on Chinese herbal medicine gout for the treatment of goat of the present invention.
Claims (10)
1. treat a compositions for the Chinese medicine of goat, it is characterized in that comprising following raw material: Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis, the Radix Paeoniae Alba.
2. the compositions of the Chinese medicine for the treatment of goat as claimed in claim 1, is characterized in that the weight portion proportioning of described raw material is: Radix Salviae Miltiorrhizae 15 ?50, Caulis Spatholobi 10 ?35, Radix Achyranthis Bidentatae 1 ?25, Fructus Chaenomelis 1 ?20, the Radix Paeoniae Alba 10 ?50.
3. the compositions of the Chinese medicine for the treatment of goat as claimed in claim 2, is characterized in that the weight portion proportioning of described raw material is: Radix Salviae Miltiorrhizae 25 ?40, Caulis Spatholobi 20 ?30, Radix Achyranthis Bidentatae 5 ?15, Fructus Chaenomelis 5 ?15, the Radix Paeoniae Alba 20 ?40.
4. the compositions of the Chinese medicine for the treatment of goat as claimed in claim 3, is characterized in that the weight portion proportioning of described raw material is: Radix Salviae Miltiorrhizae 30, Caulis Spatholobi 20, Radix Achyranthis Bidentatae 10, Fructus Chaenomelis 10, the Radix Paeoniae Alba 30.
5. as described in as arbitrary in claim 1 to 4, a preparation method for the compositions of the Chinese medicine for the treatment of goat, comprises the steps:
1) prepare raw material according to following weight portion proportioning:
Radix Salviae Miltiorrhizae 15 ?50, Caulis Spatholobi 10 ?35, Radix Achyranthis Bidentatae 1 ?25, Fructus Chaenomelis 1 ?20, the Radix Paeoniae Alba 10 ?50;
2) by after described crude drug Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis mix homogeneously, mixed material medicine is carried out to heating extraction, collect extracting solution;
3) to collect extracting solution carry out concentration, make Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis concentrated solution;
4) the crude drug Radix Paeoniae Alba is carried out to pulverization process, make Radix Paeoniae Alba fine powder;
5) Dan Can ?Ji Xue Teng ?Niu Xi ?Fructus Chaenomelis concentrated solution mix homogeneously and get final product with Radix Paeoniae Alba fine powder.
6. preparation method as claimed in claim 5, is characterized in that step 2) described in heating extraction comprise as follows step in sequence:
A) mixture is added to water soaking, the weight of the water adding is 6 ?10:1 with the ratio of the weight of mixture, soaks 1 ?and after 3 hours, carries out heating extraction for the first time, and heating-up temperature is 100 DEG C, is to extract 1 ?3 hours under the condition of 100 DEG C keeping temperature;
B) extracting solution filters for the first time, collects filtrate;
C) in filtering residue, add water, carry out heating extraction for the second time, wherein, the weight of the water adding and the ratio of the weight of mixture be 5 ?10:1, heating-up temperature is 100 DEG C, keep temperature be under the condition of 100 DEG C, extract 1 ?3 hours;
D) filter, the filtrate of twice filtration is merged.
7. preparation method as claimed in claim 6, is characterized in that, steps A) described in heating extraction time 1.5 ?2.5 hours, the weight of the water adding and the ratio of the weight of mixture be preferably 7 ?8:1; Step C) in the ratio of the weight of water that adds and the weight of mixture be 5 ?7:1.
8. the preparation method as described in claim 5 or 6, is characterized in that step 3) described in filtrate concentration process in control temperature be 80 ?100 DEG C, relative pressure Di Yu ?0.05MPa.
9. the preparation method as described in claim 5 or 6, is characterized in that step 3) described in the weight of concentrated solution and the ratio of the gross weight of crude drug Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Achyranthis Bidentatae, Fructus Chaenomelis be 0.5 ?0.85:1.
10. the preparation method as described in claim 5 or 6, it is characterized in that also comprising to Dan Can ?Ji Xue Teng ?Niu Xi ?add pharmaceutically acceptable adjuvant in Fructus Chaenomelis concentrated solution and Radix Paeoniae Alba fine powder mixture, mix.
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| CN106389572A (en) * | 2016-10-29 | 2017-02-15 | 南宁多灵生物科技有限公司 | Traditional Chinese medicine composition for treating gout |
| CN106806632A (en) * | 2015-11-30 | 2017-06-09 | 张恩林 | A kind of selenium-rich beverage with reduction high lithemia effect |
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| CN1313111A (en) * | 2000-03-15 | 2001-09-19 | 蒲荣 | Health-care medical wine for invigorating function of kidney and strengthening bone |
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