CN105998256A - Medicament for treating urinary calculus and preparation method of medicament - Google Patents
Medicament for treating urinary calculus and preparation method of medicament Download PDFInfo
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- CN105998256A CN105998256A CN201610596815.XA CN201610596815A CN105998256A CN 105998256 A CN105998256 A CN 105998256A CN 201610596815 A CN201610596815 A CN 201610596815A CN 105998256 A CN105998256 A CN 105998256A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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Abstract
The invention discloses a medicament for treating urinary calculus and a preparation method of the medicament and belongs to the field of urology department. The medicament is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 80 to 100 parts of stenoloma chusana, 0 to 2 parts of semen persicae, 0 to 10 parts of honey and 0 to 8 parts of liquorice root tip. The preparation method comprises the following steps of respectively weighing fresh stenoloma chusana,, semen persicae and liquorice root tip according to the proportions; cleaning and then juicing and filtering; adding the honey into filtrate and uniformly stirring; concentrating filtrate under reduced pressure to form extract; finally, adding pharmaceutically acceptable excipients serving as auxiliary materials according to conventional working procedures to obtain clinically acceptable dosage forms. The formula of the medicament is simple and rigorous and is scientific in matching; all the materials are common traditional Chinese medicines, are low in price and definite in curative effect; the medicament is high in patient compliance and is suitable for popularization.
Description
Technical field
The present invention relates to urology department technical field, be specifically related to a kind of medicine treating urinary system calculus and system thereof
Preparation Method.
Background technology
Urinary system calculus is called for short urinary calculi, refers to form granule or in bulk at urinary system endogenous cause of ill urine concentrating and precipitating
Sample aggregation, including renal calculus, ureteral calculus, vesical calculus and lithangiuria, for urological common
Disease and frequently-occurring disease, the formation of urinary system calculus has close with environmental factors, general pathological changes and diseases of urinary system
Cut relation, mainly show as waist abdomen have an intense pain, hematuria, and have the symptom such as Nausea and vomiting, dripping sweat,
Causing great misery for patient, be apt to occur in male adults, sickness rate is on the rise in recent years.
Clinical treatment urinary system calculus generally use external stone crushing, operation, percutaneous nephrolithotomy treatment with
And the method such as Drug therapy.Operation calculus is traumatic greatly, easily cause infection, it is difficult to effectively effect a radical cure, and
Easily recurrence, causes certain infringement to human body and organ.The curative effect of medication for the treatment of urinary system calculus is limited at present,
And it is big to there is dose, the shortcoming of calculus cycle length.
Summary of the invention
In order to overcome the deficiencies in the prior art, it is an object of the invention to provide a kind of urinary system calculus for the treatment of
Medicine, this medicament composing prescription is the most rigorous, compatibility science, is common Chinese medicine, low price, clear curative effect,
Patient adaptability is strong, is suitable to promote.
For solving the problems referred to above, the technical solution adopted in the present invention is as follows:
A kind of medicine treating urinary system calculus, it is made up of following raw material of Chinese medicine by weight: Folium Stenolomatis
80～100 parts, Semen Persicae 0～2 parts, Mel 0～10 parts, Radix Glycyrrhizae uralensis 0～8 parts.
Currently preferred technical scheme is, the medicine for the treatment of urinary system calculus of the present invention is by following
Raw material of Chinese medicine by weight is made: Folium Stenolomatis 85～95 parts, Semen Persicae 1～2 parts, Mel 4～8 parts, Radix Glycyrrhizae
The tip 2～6 parts.
The most preferred technical scheme of the present invention is, the medicine for the treatment of urinary system calculus of the present invention be by with
Under raw material of Chinese medicine by weight make: Folium Stenolomatis 90 parts, 2 parts of Semen Persicae, Mel 4 parts, Radix Glycyrrhizae uralensis 4 parts.
Preferably, described medicine can be tablet, decoction, granule, capsule or oral liquid.
Present invention also offers the preparation method of a kind of medicine as above, comprise the following steps: in proportion
Weigh after fresh Folium Stenolomatis, Semen Persicae and Radix Glycyrrhizae uralensis clean up respectively, squeeze the juice, filter；Add in filtrate
Mel stirs, and filtrate reduced in volume becomes extractum, eventually passes normal process steps and adds pharmaceutically acceptable
Excipients makes the most acceptable dosage form.
Pharmacology and the drug effect of each Chinese medicinal components that the present invention is above-mentioned be:
Folium Stenolomatis, also known as Folium Stenolomatis, mildly bitter flavor, puckery, cool in nature, have heat-clearing and toxic substances removing, hemostasia and promoting granulation,
The effects such as activating blood and eliminatng dampness, herb controls bacillary dysentery, gastroenteritis, and urethritis is spitted blood, had blood in stool, hematuria, urine leaching
Bitterly.
Semen Persicae, bitter in the mouth, property put down, GUIXIN, kidney, large intestine channel, have invigorate blood circulation, blood stasis dispelling, intestine moistening, relieving constipation,
The effects such as heat clearing away, removing dampness, eliminating stagnation, pain relieving, blood circulation promoting and blood stasis dispelling effect is very wide, and available to control stagnation of blood stasis various worn-out
Disease.Being good at treating abscess of internal organ in clinic, if lung abscess, acute appendicitis are key medicine, be that it has peculiar performance Yu, fat is many
Matter is moistened, the merit of tool loosening bowel to relieve constipation.
Mel, sweet in the mouth acid, property put down, enter lung, spleen, stomach, large intestine channel, have invigorating middle warmer, moisturize, pain relieving,
Effect of removing toxic substances, strengthens the spleen and stomach, can strengthen the digestive function of taste, beneficially removing food stagnancy fossil, and can delay
Suddenly relieving the pain, pain when showing effect calculus can obviously relieve；Mel owing to being the elite adopting many flowers, all flowers it
Abnormal smells from the patient ferments unification, so the most adjustable hundred medicines, emergency relieves the pain.In the present invention, Mel preferably has
The Mel of clearing away heat and promoting diuresis effect.
Radix Glycyrrhizae uralensis, the last ending for glycyrrhizic legume root divides or radicula, sweet in the mouth, cold in nature, GUIXIN, liver,
Spleen channel, has effect of eliminating fire and detoxication, inducing diuresis for treating stranguria syndrome, cure mainly in pyretic stranguria, oliguria, penis pain and
Stranguria with turbid discharge.
Tcm prescription theory is thought, each prescription, not only needs suitably to post appropriate according to etiology and pathogenesis selection
Kind compatibility, also should comply with the basic structure of prescription simultaneously, i.e. the prescription compatibility of " monarch, minister, help, make "
Theory, the prescription compatibility of so-called " monarch, minister, help, make ", it is simply that act the full side set up to disease pathogenesis
Scientific matching on the judgement basis of position.In medical side by too many levels, Mutiple Targets Integrate adjustment biology several
Only, the therapeutic effect that, more green natural more more longlasting than Western medicine has no side effect can be obtained, and this curative effect
Being built upon on the accurate instruction of the above-mentioned traditional Chinese medical science original theory of tradition, the present invention just have followed this principle.
The medicine of the treatment urinary system calculus of the present invention according to the prescription compatibility theory compatibility of " monarch, minister, help, make ",
With Folium Stenolomatis as monarch drug, clearing away heat-damp and promoting diuresis；With Radix Glycyrrhizae uralensis as ministerial drug, inducing diuresis for treating stranguria syndrome；With Semen Persicae as adjuvant drug, heat clearing away
Removing dampness；With Mel for making medicine, digest JISHI；Four Chinese medicine compatibility apply, play altogether clearing away heat and eliminating dampness inducing diuresis for treating stranguria syndrome it
Merit, the effect of the molten discharge calculus that reaches to disappear.
Compared to existing technology, the beneficial effects of the present invention is:
Between pharmaceutical formulation every taste Chinese medicine for the treatment of urinary system calculus of the present invention, joined by clinic for several times
Drawing behind side, the Chinese medicine ingredients in formula reaches to treat the effect of urinary system calculus by following pharmacy principle: 1,
Diuresis: increase calculus effect by diuresis effect of Folium Stenolomatis, Radix Glycyrrhizae uralensis and Mel；2, relaxing smooth muscle
Effect: release ureteral spasm by the similar adrenocortical hormone sample effect relaxing smooth muscle of Radix Glycyrrhizae uralensis
Arrive the purpose reducing pain；3, antiinflammation: by the antiinflammation of Amygdalin in Semen Persicae, Radix Glycyrrhizae uralensis
Antiinflammatory action and Mel antiinflammation reduce urinary system inflammation, reach antiphlogistic effects.By above-mentioned pharmacy
Principle understands, and the four Chinese medicine in the present invention has synergism each other.Chinese medicine composition of the present invention
Thing has the effects such as fossil diuresis, Tonglin Paishi, blood circulation promoting and blood stasis dispelling, clearing away heat and eliminating dampness, removing obstruction for relieving pain, to urinary system
Tying stone has good therapeutic effect；Its manufacture method is simple, can be fabricated to as required tablet,
The dosage forms such as granule, decoction or oral liquid；The pharmaceutical formulation low cost of the present invention, need not perform the operation, and patient is prone to
Accepting, clear curative effect, cure rate is high.
Detailed description of the invention
The present invention is described in further detail by embodiment in detail below.
Embodiment 1:
A kind of medicine treating urinary system calculus, it is made up of following raw material of Chinese medicine by weight: crow
Herba pteridii latiusculi 80 parts, 2 parts of Semen Persicae, Mel 10 parts, Radix Glycyrrhizae uralensis 8 parts.
Embodiment 2:
A kind of medicine treating urinary system calculus, it is made up of following raw material of Chinese medicine by weight: crow
Herba pteridii latiusculi 90 parts, 2 parts of Semen Persicae, Mel 4 parts, Radix Glycyrrhizae uralensis 4 parts.
Embodiment 3:
A kind of medicine treating urinary system calculus, it is made up of following raw material of Chinese medicine by weight: crow
Herba pteridii latiusculi 95 parts, 1 part of Semen Persicae, Mel 2 parts, Radix Glycyrrhizae uralensis 2 parts.
Embodiment 4:
A kind of medicine treating urinary system calculus, it is made up of following raw material of Chinese medicine by weight: crow
Herba pteridii latiusculi 85 parts, 2 parts of Semen Persicae, Mel 6 parts, Radix Glycyrrhizae uralensis 7 parts.
Embodiment 5:
A kind of medicine treating urinary system calculus, it is made up of following raw material of Chinese medicine by weight: crow
Herba pteridii latiusculi 100 parts.
The preparation method of above example is as follows: weigh fresh Folium Stenolomatis, Semen Persicae and Radix Glycyrrhizae uralensis the most respectively
After cleaning up, squeeze the juice, filter；Adding Mel in filtrate to stir, filtrate reduced in volume becomes extractum,
Eventually pass the normal process steps pharmaceutically acceptable excipients of addition and make the most acceptable dosage form.
Clinical trial:
For investigating clinical efficacy and the safety of medicine of the present invention further, we have selected 300 example urinary systems
System calculus patient carries out clinical trial to the treatment curative effect of medicine of the present invention.
300 example urinary system calculus patients are randomly divided into two groups, often 150 patients of group, in matched group,
Male 89 example, women 61 example, less than 20 years old 50 examples, 20～40 years old 54 example, more than 50 years old person 46 example,
The course of disease one month to 6 years；In treatment group, male 83 example, women 67 example, less than 20 years old 54 examples, 20～40
Year 56 examples, more than 50 years old person 40 example, the course of disease two months to 8 years.Calculus happening part: matched group kidney is tied
Stone 56 example, ureteral calculus 43 example, vesical calculus 51 example；Treatment group renal calculus 50 example, ureter is tied
Stone 43 example, vesical calculus 57 example.Wherein matched group calculus is 0.9cm × 1.2cm to the maximum；Treatment group calculus is
Greatly 1.2cm × 1.0cm.
Two groups of cases through statistical analysis, have comparability at aspects such as sex, age, the courses of disease.Institute is ill
Example all diagnoses with reference to the diagnostic criteria of urinary system calculus in " internal medicine ".
Matched group employing appropriate exercise, rational diet, and oral potassium citrate 30mg, three times a day；Treatment
The oral administration solution of the oral medicine of the present invention of group, potion on the one, three times on the one.
Criterion of therapeutical effect:
Cure clinical symptom disappearance, ultrasound diagnosis and/or urinary system radiography and find that calculus disappears:
Effective clinical symptom disappearance, calculus is obviously reduced or quantity reduces；
Effective clinical remission or be obviously improved；
Invalid calculus is without significant change.
Curative effect comparision result after two groups of case treatments is as follows:
Table 1 treatment group contrasts with the efficacy result of matched group
| Group | Number of cases | Cure rate | Obvious effective rate | Effective percentage | Inefficiency | Relapse rate |
| Matched group | 150 | 61 (40%) | 112 (75%) | 125 (83%) | 25 (17%) | 48 (32%) |
| Treatment group | 150 | 108 (72%) | 137 (91%) | 144 (96%) | 6 (4%) | 10 (6.6%) |
From the above results, Drug therapy urinary system calculus 150 example of the application present invention, effective 144 examples,
Effective percentage reaches 96%, cures 108 examples, cure rate 72%.
Model case:
Chen, man, 40 years old, for many years, B ultrasonic showed double kidney silt particle sample calculus to calculus medical history, uses mouth always
Take SHILINTONG PIAN to fail to respond to any medical treatment.After take two courses for the treatment of of medicine of the present invention after, symptom disappears substantially, multiple
Looking into B ultrasonic, double kidneys do not find calculus.
Week certain, female, 38 years old, calculus medical history.Dolantin pain relieving, DeGrain is used for the first time during outbreak.
After take medicine of the present invention, the same day, pain was substantially alleviated.Recur again after 1 year, use dolantin pain relieving,
Effect is the most inconspicuous.After take medicine of the present invention, the same day, pain was substantially alleviated.After take the present invention
After five courses for the treatment of of described medicine, then do not show effect.
Above-mentioned embodiment is only the preferred embodiment of the present invention, it is impossible to limit present invention protection with this
Scope, the change of any unsubstantiality that those skilled in the art is done on the basis of the present invention and replacement
Belong to scope of the present invention.
Claims (5)
1. the medicine treating urinary system calculus, it is characterised in that: it is by following Chinese medicine by weight
Raw material is made: Folium Stenolomatis 80～100 parts, Semen Persicae 0～2 parts, Mel 0～10 parts, Radix Glycyrrhizae uralensis 0～8 parts.
The medicine for the treatment of urinary system calculus the most according to claim 1, it is characterised in that: it is by following
Raw material of Chinese medicine by weight is made: Folium Stenolomatis 85～95 parts, Semen Persicae 1～2 parts, Mel 4～8 parts, Radix Glycyrrhizae
The tip 2～6 parts.
The medicine for the treatment of urinary system calculus the most according to claim 1, it is characterised in that: it is by following
Raw material of Chinese medicine by weight is made: Folium Stenolomatis 90 parts, 2 parts of Semen Persicae, Mel 4 parts, Radix Glycyrrhizae uralensis 4 parts.
The medicine for the treatment of urinary system calculus the most according to claim 1, it is characterised in that: described medicine
For tablet, decoction, granule, capsule or oral liquid.
5. the preparation method of a medicine as claimed in claim 1, it is characterised in that: comprise the following steps:
Weigh after fresh Folium Stenolomatis, Semen Persicae and Radix Glycyrrhizae uralensis clean up the most respectively, squeeze the juice, filter；To filtrate
Middle addition Mel stirs, and filtrate reduced in volume becomes extractum, eventually passes normal process steps addition and pharmaceutically may be used
The excipients accepted makes the most acceptable dosage form.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610596815.XA CN105998256A (en) | 2016-07-26 | 2016-07-26 | Medicament for treating urinary calculus and preparation method of medicament |
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| CN201610596815.XA CN105998256A (en) | 2016-07-26 | 2016-07-26 | Medicament for treating urinary calculus and preparation method of medicament |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529593A (en) * | 2020-06-02 | 2020-08-14 | 昆明市中医医院 | Traditional Chinese medicine composition for preventing and treating phlegm-dampness urinary uric acid calculus and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000142A (en) * | 2010-11-15 | 2011-04-06 | 卢爱军 | Traditional Chinese medical composition for treating urinary calculi |
| CN104001082A (en) * | 2014-06-13 | 2014-08-27 | 刘玉栋 | Traditional Chinese medicine for treating damp-heat stasis type kidney calculi |
-
2016
- 2016-07-26 CN CN201610596815.XA patent/CN105998256A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000142A (en) * | 2010-11-15 | 2011-04-06 | 卢爱军 | Traditional Chinese medical composition for treating urinary calculi |
| CN104001082A (en) * | 2014-06-13 | 2014-08-27 | 刘玉栋 | Traditional Chinese medicine for treating damp-heat stasis type kidney calculi |
Non-Patent Citations (2)
| Title |
|---|
| 钱永涛: "《药用植物彩色图谱》", 31 August 2009, 浙江科学技术出版社 * |
| 陈光家等: ""《金石汤》治疗尿路结石30例临床分析"", 《海南卫生》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529593A (en) * | 2020-06-02 | 2020-08-14 | 昆明市中医医院 | Traditional Chinese medicine composition for preventing and treating phlegm-dampness urinary uric acid calculus and preparation method thereof |
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Application publication date: 20161012 |