CN110893206B

CN110893206B - Externally applied medicine for treating rheumatic arthritis and preparation method thereof

Info

Publication number: CN110893206B
Application number: CN201911121474.0A
Authority: CN
Inventors: 荆家勇
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-15
Filing date: 2019-11-15
Publication date: 2022-02-01
Anticipated expiration: 2039-11-15
Also published as: CN110893206A

Abstract

The embodiment of the invention discloses an external medicine for treating rheumatic arthritis and a preparation method thereof, belonging to the technical field of medicines. The external medicine is prepared from the following raw materials in parts by weight: 35-45 parts of camphorwood, 25-35 parts of pokeberry root, 1.5-2.5 parts of pepper, 3-8 parts of plantain herb and 3-8 parts of white spirit. The external medicine for treating rheumatic arthritis takes camphor wood, pokeberry root, pepper and plantain herb as raw materials, is obvious in synergistic effect by combining the raw materials, has the effects of dispelling wind and removing dampness, relaxing tendons and activating collaterals, and dispelling cold and relieving pain, and has a good curative effect on rheumatic arthritis. The external medicine provided by the invention has no irritation to skin, high safety, no obvious toxic or side effect on organisms and wide application prospect.

Description

Externally applied medicine for treating rheumatic arthritis and preparation method thereof

Technical Field

The embodiment of the invention relates to the technical field of medicines, and particularly relates to an external medicine for treating rheumatic arthritis and a preparation method thereof.

Background

Rheumatic arthritis is a common acute or chronic inflammation of connective tissue, belongs to allergic diseases, is one of the main manifestations of rheumatic fever, and is mostly caused by acute fever and arthralgia. Rheumatic arthritis belongs to the arthralgia of traditional Chinese medicine, joint pain is the primary symptom of the rheumatic arthritis, and pain can occur to joints of the whole body, but the large joints are affected more commonly, such as knee joints, ankle joints, shoulder joints and wrist joints. Typically, it is manifested as symmetrical, migratory pain, and inflammation accompanied by redness, swelling, and heat.

Although the rheumatic arthritis does not endanger the life of the patient, the rheumatic arthritis causes great pain and suffering to the patient, causes much trouble to the normal life of the patient and seriously threatens the physical and psychological health of the patient.

At present, the treatment of rheumatic arthritis mainly comprises physical treatment and drug therapy such as acupuncture and moxibustion, cupping and the like. The physical therapy has poor pertinence and generally reflects poor treatment effect. The drug therapy comprises oral western medicines, oral traditional Chinese medicines and external medicines, the pain of patients is reduced by oral anti-inflammatory drugs, but the oral anti-inflammatory drugs have obvious side effects, the liver is greatly stressed by frequent administration, the treatment is not facilitated, and the oral western medicines are easy to generate drug resistance, long in treatment time and poor in effect.

The traditional Chinese medicine is used for treating diseases according to the nature and taste of the medicine, focuses on conditioning and preventing, enables the organism of a human body to gradually recover to a normal state, and has the advantages of treating both symptoms and root causes and having small side effect. However, the existing traditional Chinese medicine for treating rheumatoid arthritis has the defects of various medicinal components, unobvious synergistic effect among the components and inaccurate curative effect.

Disclosure of Invention

Therefore, the embodiment of the invention provides an external medicine for treating rheumatoid arthritis and a preparation method thereof, aiming at solving the defects of various medicine components, unobvious synergistic action among the components and inaccurate curative effect of the traditional Chinese medicine for treating rheumatoid arthritis.

In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:

according to a first aspect of embodiments of the present invention, the present invention provides an external medicine for treating rheumatoid arthritis, which is prepared from the following raw materials in parts by weight: 35-45 parts of camphorwood, 25-35 parts of pokeberry root, 1.5-2.5 parts of pepper, 3-8 parts of plantain herb and 3-8 parts of white spirit.

In a preferred embodiment, the external medicine is prepared from the following raw materials in parts by weight: 40 parts of camphorwood, 30 parts of pokeberry root, 2 parts of pepper, 5 parts of plantain herb and 5 parts of white spirit.

In a preferred embodiment, the external medicine is prepared from the following raw materials in parts by weight: 42 parts of camphorwood, 28 parts of pokeberry root, 1.5 parts of pepper, 6 parts of plantain herb and 8 parts of white spirit.

In a preferred embodiment, the external medicine is prepared from the following raw materials in parts by weight: 35 parts of camphor wood, 35 parts of pokeberry root, 1.8 parts of pepper, 4 parts of plantain herb and 3 parts of white spirit.

In a preferred embodiment, the external medicine is prepared from the following raw materials in parts by weight: 38 parts of camphorwood, 35 parts of pokeberry root, 2.2 parts of pepper, 3 parts of plantain herb and 7 parts of white spirit.

In a preferred embodiment, the external medicine is prepared from the following raw materials in parts by weight: 45 parts of camphorwood, 25 parts of pokeberry root, 2.5 parts of pepper, 8 parts of plantain herb and 5 parts of white spirit.

In a preferred embodiment, the degree of the white spirit is 45-65.

According to a second aspect of the embodiments of the present invention, there is provided a method for preparing the above-mentioned external medicine for treating rheumatoid arthritis, the method comprising the steps of:

1) preparing raw materials according to a formula;

2) pulverizing lignum Cinnamomi Camphorae, radix Phytolaccae, fructus Zanthoxyli, and herba plantaginis into coarse powder;

3) placing the pulverized medicinal materials in Chinese liquor, heating until bubbles appear in the pan, and stopping heating.

The raw materials of the invention have the following properties and efficacies:

camphor wood: pungent flavor and warm nature. Enter liver and spleen meridians. Has the effects of expelling wind and cold, warming middle-jiao and regulating qi, and promoting blood circulation and removing obstruction in channels. Can be used for treating wind-cold type common cold, stomach cold distending pain, vomiting and diarrhea due to cold-dampness, rheumatalgia, loempe, traumatic injury pain, scabies, tinea, and wind itching.

Pokeberry root: bitter taste and cold nature. It enters lung, spleen, kidney and large intestine meridians. Has the effects of expelling water and reducing swelling, and promoting urination and defecation, and has the effects of detoxifying and dissipating stagnation when being externally used. It is commonly used for edema, fullness and distention, constipation and constipation; it is indicated for abscess, swelling and sore.

Chinese prickly ash: pungent and warm. Enter spleen, lung and kidney meridians. Has effects of warming spleen and stomach, relieving pain, killing parasites and relieving itching. It can be used for treating middle-cold abdominal pain, vomiting and diarrhea due to cold-dampness, abdominal pain due to parasitic infestation, eczema, and pudendal pruritus.

Plantain herb: sweet and cold in nature. It enters liver, kidney, lung and small intestine meridians. Has the effects of clearing heat, promoting urination, cooling blood and removing toxic substances. It can be used for treating heat accumulation in bladder, dysuria, stranguria with turbid discharge, summer-heat, dampness, dysentery, epistaxis, hematuria, liver heat, conjunctival congestion, sore throat, carbuncle, swelling, and sore.

The embodiment of the invention has the following advantages:

the external medicine for treating rheumatic arthritis takes camphor wood, pokeberry root, pepper and plantain herb as raw materials, is obvious in synergistic effect by combining the raw materials, has the effects of dispelling wind and removing dampness, relaxing tendons and activating collaterals, and dispelling cold and relieving pain, and has a good curative effect on rheumatic arthritis. The external medicine provided by the invention has no irritation to skin, high safety, no obvious toxic or side effect on organisms and wide application prospect.

Detailed Description

The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The external medicine for treating rheumatoid arthritis is prepared from the following raw materials in parts by weight: 400 g of camphor wood, 300 g of pokeberry root, 20 g of pepper, 50 g of plantain herb and 50 g of white spirit.

The preparation method comprises the following steps:

1) preparing raw materials according to a formula;

3) placing the pulverized medicinal materials in 55% (v/v) Chinese liquor, heating until bubbles appear in the pan, and stopping heating.

Example 2

The external medicine for treating rheumatoid arthritis is prepared from the following raw materials in parts by weight: 420 g of camphor wood, 280 g of pokeberry root, 15 g of pepper, 60 g of plantain herb and 80 g of white spirit.

The preparation method of the external medicine of this example is the same as that of example 1.

Example 3

The external medicine for treating rheumatoid arthritis is prepared from the following raw materials in parts by weight: 350 g of camphor wood, 350 g of pokeberry root, 18 g of pepper, 40 g of plantain herb and 30 g of white spirit.

Example 4

The external medicine for treating rheumatoid arthritis is prepared from the following raw materials in parts by weight: 380 g of camphorwood, 350 g of pokeberry root, 22 g of pepper, 30 g of plantain herb and 70 g of white spirit.

Example 5

The external medicine for treating rheumatoid arthritis is prepared from the following raw materials in parts by weight: 450 g of camphorwood, 250 g of pokeberry root, 25 g of pepper, 80 g of plantain herb and 50 g of white spirit.

Comparative example 1

The external medicine for treating rheumatoid arthritis of the comparative example is prepared from the following raw materials in parts by weight: 400 g of camphor wood, 20 g of pepper and 25 g of white spirit.

Comparative example 2

The external medicine for treating rheumatoid arthritis of the comparative example is prepared from the following raw materials in parts by weight: 400 g of camphorwood, 300 g of coptis root, 20 g of pepper, 50 g of plantain herb and 50 g of white spirit.

Clinical trial

210 patients diagnosed with rheumatoid arthritis were selected and all volunteered to participate in the trial. Patients were divided into treatment 1-5 groups and control 1-2 groups of 30 people each, using a randomized cohort approach. And counting diseased sites of the patients of the treatment group and the control group, wherein:

in the treatment 1 group, 13 patients suffered from knee joint diseases, 8 patients suffered from ankle joint diseases, and 11 patients suffered from elbow joint diseases;

in the treatment 2 groups, 10 people suffered from knee joint diseases, 14 people suffered from ankle joint diseases and 11 people suffered from elbow joint diseases;

in the treatment 3 groups, the number of people with knee joint diseases is 15, the number of people with ankle joint diseases is 8, and the number of people with elbow joint diseases is 8;

in the treatment 4 groups, 9 people suffered from knee joint diseases, 9 people suffered from ankle joint diseases and 13 people suffered from elbow joint diseases;

in the treatment 5 groups, the number of patients with knee joint diseases was 11, the number of patients with ankle joint diseases was 11, and the number of patients with elbow joint diseases was 12;

in the control 1 group, 9 patients suffered from knee joint, 15 patients suffered from ankle joint, and 10 patients suffered from elbow joint;

in the control 2 group, 12 patients suffered from knee joint, 7 patients suffered from ankle joint, and 15 patients suffered from elbow joint.

The patients in treatment groups 1-5 and control groups 1-2 were statistically not valuable and comparable in their age, duration of disease onset, and level of pain and joint area.

The external drugs of examples 1 to 5 and comparative examples 1 to 2 were used in the treatment group and the control group, respectively, according to the following methods: soaking the affected part in the medicine 1 time per day for 1 hr, and 30 days as a treatment course for 3 treatment courses.

The criteria for efficacy assessment are as follows:

the effect is shown: after treatment, symptoms such as arthralgia and swelling of the patient disappear, and joint movement returns to normal;

the method has the following advantages: the symptoms of arthralgia, swelling and the like of the patient are relieved after treatment, and the joint movement is recovered;

after the treatment, the above indexes are not reached, and the effect is not achieved.

The results of comparing the clinical efficacy of the treatment group and the control group are shown in Table 1.

TABLE 1

Group of	Number of affected parts	Show effect	Is effective	Invalidation	The total effective rate%
						Treatment 1 group	32	14	17	1	96.7
Treatment of 2 groups	35	13	19	3	91.4
						Treatment of 3 groups	31	11	18	2	93.5
Treatment of 4 groups	31	12	16	3	90.3
						Treatment of 5 groups	34	12	19	3	91.2
Control 1 group	34	7	15	12	64.7
						Control 2 group	34	8	17	9	73.5

As shown in Table 1, the total clinical efficacy of the patients in the treatment group is significantly higher than that in the control group, and the data difference is statistically significant (P < 0.05).

Adverse drug reactions: compared with the detection before treatment, the detection of various indexes of liver function, kidney function and blood routine has no statistical significance after half a year of treatment, and the application safety of the external medicine is proved.

Typical case

The inventor takes sixteen joints of four fingers and is full of pain when the inventor is in sixteen and seven years old, the first time is worship, the second time is half a month, and the inventor takes the medicine after injection at that time, but the inventor self-heals the medicine afterwards. Three years ago, the finger joints are continuously painful, and the finger joints go to several hospitals, and the examination results are the same, namely the early stage of arthritis. The medicine taken for more than one year is intermittent, the pain can be relieved, and the root can not be removed, so that the oral medication is abandoned. After the traditional Chinese medicine treatment is tried, hands are soaked in the medicine of the comparative example 1, the pain can be relieved after the treatment for half a month, the roots cannot be removed, the treatment is maintained, and the patients cannot be tendered until the hands fall into the winter, so the treatment is carried out by adopting the external medicine of the real-time example 1, the pain is eliminated after the hands are soaked for one half hour, the pain is relieved after the hands fall into the winter, and the hands are healed and have not relapsed to date.

Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. The external medicine for treating the rheumatic arthritis is characterized by being prepared from the following raw materials in parts by weight: 35-45 parts of camphorwood, 25-35 parts of pokeberry root, 1.5-2.5 parts of pepper, 3-8 parts of plantain herb and 3-8 parts of white spirit; the degree of the white spirit is 45-65 degrees.

2. The external medicine for treating rheumatoid arthritis according to claim 1, wherein the external medicine is prepared from the following raw materials in parts by weight: 40 parts of camphorwood, 30 parts of pokeberry root, 2 parts of pepper, 5 parts of plantain herb and 5 parts of white spirit.

3. The external medicine for treating rheumatoid arthritis according to claim 1, wherein the external medicine is prepared from the following raw materials in parts by weight: 42 parts of camphorwood, 28 parts of pokeberry root, 1.5 parts of pepper, 6 parts of plantain herb and 8 parts of white spirit.

4. The external medicine for treating rheumatoid arthritis according to claim 1, wherein the external medicine is prepared from the following raw materials in parts by weight: 35 parts of camphor wood, 35 parts of pokeberry root, 1.8 parts of pepper, 4 parts of plantain herb and 3 parts of white spirit.

5. The external medicine for treating rheumatoid arthritis according to claim 1, wherein the external medicine is prepared from the following raw materials in parts by weight: 38 parts of camphorwood, 35 parts of pokeberry root, 2.2 parts of pepper, 3 parts of plantain herb and 7 parts of white spirit.

6. The external medicine for treating rheumatoid arthritis according to claim 1, wherein the external medicine is prepared from the following raw materials in parts by weight: 45 parts of camphorwood, 25 parts of pokeberry root, 2.5 parts of pepper, 8 parts of plantain herb and 5 parts of white spirit.

7. A method for preparing the external medicine for treating rheumatoid arthritis according to claim 1, comprising the steps of:

1) preparing raw materials according to a formula;