CN102430018B - Medicinal composition for treating rheumatic and rheumatoid arthritis - Google Patents

Medicinal composition for treating rheumatic and rheumatoid arthritis Download PDF

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CN102430018B
CN102430018B CN201110382506XA CN201110382506A CN102430018B CN 102430018 B CN102430018 B CN 102430018B CN 201110382506X A CN201110382506X A CN 201110382506XA CN 201110382506 A CN201110382506 A CN 201110382506A CN 102430018 B CN102430018 B CN 102430018B
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rheumatoid arthritis
medicinal composition
treatment
pharmaceutical composition
pain
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朱金光
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Abstract

The invention discloses a medicinal composition for treating rheumatic and rheumatoid arthritis. The composition consists of twig and leaf of common tupidanthus, pangolin, Fructus evodiae, realgar, long-noded pit viper, angelica, Drynaria rhizome, grassleaf sweelflag rhizome, Chinese starjasmine stem, clematis root, epimedium herb, Fructus liquidambaris, rhubarb, centipede, scorpion, clove and entadae stem. The medicinal composition is prepared into clinically acceptable emplastrum, ointment, pressurized spray, liniment or tincture by adding the conventional auxiliary materials according to the conventional process. The medicinal composition has the effects of expelling pathogenic wind and removing moisture, subsiding swelling and relieving pain, promoting blood circulation and removing blood stasis, warming meridians and unblocking collaterals. The medicinal composition has obvious effect and has no toxic or side effect on the treatment of the rheumatic and rheumatoid arthritis.

Description

A kind of pharmaceutical composition for the treatment of rheumatism and rheumatoid arthritis
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of rheumatism and rheumatoid arthritis.
Background technology
Rheumatism belongs to arthromyodynia one class, " so-called numbness person, each with reinfection at that time in the wet gas of wind and cold also "; The cause of disease of disadvantage is a lot, but nothing more than exopathogenic factor and endogenous cause of ill.Brilliantly point out in " Plain Questions numbness opinion ": " wet three gas of wind and cold are assorted extremely, close and are numbness ... ".Modern medicine think rheumatismal pathogenic factors except wind, cold, wet, also comprise infection, immunity, metabolism, endocrine, degeneration, heredity, tumor etc.
Rheumatism and rheumatoid arthritis, the traditional Chinese medical science are thought the disease due to wind and wet two kinds of pathogenic factor combination.Disease opinion has headache, heating, slight perspiration, aversion to wind, heavy sensation of the body, dysuria, joint to ache, can not bend and stretch etc.Arthropathy still with swelling and moving obstacle, is outbreak and alleviates the chronic course of disease alternately except pain is arranged.Because patient's blood circulation is obstructed, cause muscle or organize needed nutrition to carry by blood circulation, cause patient's muscle to lack nutrition and accelerated ageing becomes stiff, serious meeting causes patient's muscle and blood vessel atrophy, some patients were and the joint can occur and disable and viscera function exhaustion.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of rheumatism and rheumatoid arthritis.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Figure BSA00000621926200011
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Figure BSA00000621926200012
Figure BSA00000621926200021
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Figure BSA00000621926200022
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Figure BSA00000621926200023
Pharmaceutical composition of the present invention adds conventional adjuvant to make the emplastrum of clinical acceptance, ointment, spray, liniment or tincture according to common process.
Pharmaceutical composition of the present invention has the effect of evil-wind expelling and dampness removing, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian.To treatment rheumatism and rheumatoid arthritis with remarkable effect, have no side effect.
Following experimental example is used for further illustrating the present invention, but is not limited to the present invention.
One, experimental example
1, clinical observation
Treatment group anthology invention emplastrum (according to embodiment 1 method preparation) treatment rheumatism and 100 patients of Rheumatoid Arthritis, male's 50 examples wherein, women's 50 examples.
Matched group selects bones and muscles pain to paste, and is produced treatment rheumatism and 100 patients of Rheumatoid Arthritis, male's 50 examples wherein, women's 50 examples by Henan Province's space health scientific research company limited.
2, medicament selection
Treatment group: emplastrum of the present invention (according to embodiment 1 method preparation), treat three courses for the treatment of (12 days courses for the treatment of), one pasted/2 days.
Matched group: bones and muscles pain pastes, and is produced by Henan Province's space health scientific research company limited, treats three courses for the treatment of (12 days courses for the treatment of), and one pasted/2 days.
3, diagnostic criteria
1. medical history: the invasion and attack history that wind-cold damp pathogen is arranged.
2. symptom: joint or muscular soreness are arranged, numb, pain.Even severe pain, movable difficult: as to meet cold aggravation.
3. sign: the joint of getting involved is because of function limitation due to pain, but alleviates after activity, and majority of cases is the pain pneumonedema only, and the minority case is in periarticular mild swelling (without red heat).
4. x ray examination: except the visible soft tissue swelling of minority case, generally without sclerotin change.
5. lab testing: erythrocyte sedimentation rate is most normal.Minority is slightly fast: antistreptolysin O (ASO), rheumatoid factor, routine blood test etc. all belong to normal.
6. prognosis: deformity is not stayed in the joint of getting involved after catabasis or healing, and joint function recovery is normal.
4, criterion of therapeutical effect
Draft as follows with reference to " in cure the desease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine 1994 implements:
Recovery from illness: tcm clinical practice symptom, sign disappear or basic the disappearance;
Produce effects: tcm clinical practice symptom, sign obviously change;
Effectively: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all without obviously improving;
5, therapeutic outcome
The Comparison of therapeutic of table 1 treatment rheumatism and rheumatoid arthritis
Group The treatment number Cure Produce effects Effectively Invalid Total effective rate
Treatment group 100 40 29 28 3 97%
Matched group 100 31 22 30 17 83%
6, conclusion
Treatment group and matched group are treated respectively three courses for the treatment of (12 days each courses for the treatment of), the treatment group invention emplastrum (according to embodiment 1 method preparation) that loses money in a business, and matched group pastes bones and muscles pain and pastes, and is produced by Henan Province's space health scientific research company limited.Therapeutic outcome shows, treatment group total effective rate 97% of the present invention, matched group total effective rate 83%.Treatment group of the present invention obviously is better than matched group.
7, discuss
In pharmaceutical composition of the present invention, the Ramulus et Folium Tupidanthi celyptrati source is leaf, the stem of dicotyledon medicine Araliaceae Ramulus et Folium Tupidanthi celyptrati; Meridian distribution of property and flavor: hardship, temperature; Enter lung, kidney,liver,spleen four warps; Effect: relaxing muscles and tendons and activating QI and blood in the collateral, the circulation of qi promoting damp eliminating, cold expelling dispels the wind, eliminating dampness to stop diarrhea.Cure mainly: be used for traumatic injury, fracture pain person, the arthralgia aggravated by cold of cold and damp stagnation, affection of exogenous wind-cold, heating fear of cold, head-body-pain; Be used for distension and fullness in the abdomen, malaise, anorexia, poor appetite, dysentery person.Squama Manis medical material Ji Yuan: be the scale of Manidae animal Manitis; Salty in the mouth; Cold nature; Return liver, the stomach warp.The Fructus Evodiae source is the almost ripe fruit of rutaceae Fructus Evodiae; Nature and flavor: hot in nature, acrid in the mouth, hardship; Slightly poisonous.Return liver, spleen, stomach, kidney channel; Function cures mainly: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal; Be used for headache, colic, beriberi, dysmenorrhea, abdominal distention, vomiting acid regurgitation, aphtha.Realgar is hot, temperature; Poisonous; Return liver, large intestine channel; Function cures mainly: detoxifcation parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria.Agkistrodon: be sharp all dry of Pallas pit viper (Agkistrodon) of kissing of Agkistrodon halys section animal; Sweet, salty, temperature; Poisonous; Return Liver Channel; Function cures mainly: dispels the wind, and collateral dredging, relieving convulsion; Be used for rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, malignant boil.Radix Angelicae Sinensis, warm in nature, sweet in the mouth, suffering; Return liver, the heart, spleen channel; Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Rhizoma Drynariae is the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi; Hardship, temperature; Return kidney, Liver Channel; Function cures mainly: the kidney invigorating bone strengthening continues and hinders pain relieving; Be used for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, the muscle fracture wound; The external treatment alopecia areata, Rhizoma Acori Graminei belongs to Acoraceae; Suffering, temperature; GUIXIN, the stomach warp; Function cures mainly: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae; Be used for the gastral cavity painful abdominal mass not hungry, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Caulis Trachelospermi is the leaf bine stem of apocynaceae plant trachelospermum jasminoide; Hardship is slightly cold; GUIXIN, liver, kidney channel; Function cures mainly: dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence; Be used for the rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.The Radix Clematidis suffering is salty, and temperature is poisonous; Enter lung, kidney two warps; Has expelling wind and removing dampness, dredge the meridian passage, diuresis, pain relieving effect; Cure mainly rheumatic ostalgia, jaundice, edema, dysuria, migraine, internal traumatic injury.Herba Epimedii is hot, sweet, temperature; Return liver, kidney channel; Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.Fructus Liquidambaris is the dry mature fruit of Hamamelidaceae Plants Chinese sweet gum; Hardship, flat; Return liver, kidney channel; Function cures mainly: dispelling, collateral-activating, and diuretic stimulates the menstrual flow; Be used for arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.Radix Et Rhizoma Rhei is being collectively referred to as of perennial plant of multiple Polygonaceae Rheum, and hardship is cold; Return the stomach warp, large intestine channel, Liver Channel, spleen channel; Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation.Scolopendra is warm in nature, and acrid in the mouth is poisonous; Return liver, spleen, lung meridian; Function with endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Scorpio is hot, and is flat; Poisonous; Return Liver Channel; Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; Be used for infantile convulsion, the tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection.Flos Caryophylli is Myrtaceae syzygium species plant Flos Caryophylli; Suffering, temperature; Effect: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI; Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.Caulis Entadae is herb or the spore of lycopsid bar helictite; Hot; Temperature; Bitter; Return liver; Urinary bladder channel; Cure mainly expelling wind and dampness; Relaxing muscles and tendons and activating QI and blood in the collateral; Eliminating stasis to stop pain; Diuresis; The main air pain of dampness syndrome; Numb hand and foot; Traumatic injury; Menoxenia.All medicine merging have the effect of evil-wind expelling and dampness removing, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian.To treatment rheumatism and rheumatoid arthritis with remarkable effect, have no side effect.
Experimental example two, model case
Case 1: Wang, female, 53 years old.Symptom: winter in 2008 whole body migration arthralgia occurred without obvious inducement, to local hospital chemical examination RF+, was diagnosed as rheumatoid arthritis, gave Radix Tripterygii Wilfordii and extract oral poor effect, arrived afterwards Beijing hospitalize, and effect is still bad.Winter in 2010, patient's interphalangeal joint pain increases the weight of and swelling occurs, bends and stretches difficulty, the slight degeneration in both hands thumb joint.By three courses for the treatment of (12 days each courses for the treatment of) of the invention emplastrum that loses money in a business (according to embodiment 1 method preparation), arthralgia is clearly better afterwards, and function of joint is obviously improved, and continues to use emplastrum of the present invention substantially to recover normally on inspection three courses for the treatment of.
Case 2: Guo, female, 55 years old.Symptom: double knee joint swelling pain 5 years, chemical examination erythrocyte sedimentation rate, anti-chain O are diagnosed as rheumatic arthritis.Oral administration antiinflammatory, analgesic drug product treatment 2 years, poor effect, dead point penicillin treatment first quarter moon, have little effect again, and oral antirheumatism traditional Chinese medicine decoction treatment is 2 years again, and effect is also undesirable, also once does Traditional Chinese medicine permeation and adds the diathermy treatment, also to no effect.Introducing by others afterwards uses ointment of the present invention (according to embodiment 2 method preparations) to treat a course for the treatment of (12 days each courses for the treatment of), symptom obviously alleviates, continue to use the ointment of the present invention just can be freely movable after two courses for the treatment of, continue to strengthen again and be completely recovered after treating two courses for the treatment of.
Case 3: Yang, the man, 40 years old, the Hefei in Anhui people, symptom: the patient got rheumatoid arthritis in the time of 40 years old, often arthralgia is stiff, once took the treatment of plurality of Chinese and Western medicine ibuprofen anti-inflammatory analgetic, pain relief after clothes, but arthroncus, regular heating, 38 ℃-39 ℃ of body temperature.Both hands foods, in, thumb moderate distortion, two elbow joinies swell and ache, not tensible.Red tongue, greasy fur, health is become thin.Blood picture: leukocyte 8000, erythrocyte 3,800,000, platelet 340,000, erythrocyte sedimentation rate 45RE+.Use spray of the present invention (according to embodiment 3 methods preparations) after two courses for the treatment of, arthralgia alleviates, and subjective symptoms takes a turn for the better.Continue subsequently to use two courses for the treatment of, the swollen joint pain disappears, and dysfunction is significantly improved.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 emplastrum
Figure BSA00000621926200061
Add conventional adjuvant to make emplastrum according to common process said medicine, one pasted/2 days.
Embodiment 2 ointments
Figure BSA00000621926200062
Add conventional adjuvant to make ointment according to common process said medicine.
Embodiment 3 sprays
Figure BSA00000621926200063
Figure BSA00000621926200071
Add conventional adjuvant to make spray according to common process said medicine.
Embodiment 4 liniments
Figure BSA00000621926200072
Add conventional adjuvant to make liniment according to common process said medicine.
Embodiment 5 tinctures
Add conventional adjuvant to make tincture according to common process said medicine.

Claims (6)

1. a pharmaceutical composition for the treatment of rheumatism and rheumatoid arthritis, is characterized in that, the crude drug of said composition consists of:
Figure FSA00000621926100011
2. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
Figure FSA00000621926100012
3. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
Figure FSA00000621926100013
4. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
Figure FSA00000621926100014
5. pharmaceutical composition as described in one of claim 1-4, is characterized in that this pharmaceutical composition adds conventional adjuvant to make the emplastrum of clinical acceptance, ointment, spray, liniment or tincture according to common process.
6. the application of pharmaceutical composition as described in one of claim 1-4 in the medicine of preparation treatment rheumatism and rheumatoid arthritis.
CN201110382506XA 2011-11-28 2011-11-28 Medicinal composition for treating rheumatic and rheumatoid arthritis Active CN102430018B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102836243B (en) * 2012-08-25 2013-11-06 李新欣 Traditional Chinese medicine for cure of rheumatoid arthritis
CN105031519A (en) * 2015-07-08 2015-11-11 济南方宇文化传媒有限公司 Arthritis-treatment traditional Chinese medicine external application preparation and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1833700A (en) * 2005-03-17 2006-09-20 乔德松 Medicinal compsns. for treating rheumatism and rheumatoid arthritis and its prepn. method
CN101129697A (en) * 2007-08-23 2008-02-27 于春杰 Orally taken traditional Chinese medicine composition for treating atrophic arthritis
CN101530566A (en) * 2008-03-10 2009-09-16 王林祥 Drug for treating rheumatism and rheumatoid disease
CN101569682A (en) * 2008-04-29 2009-11-04 北京亚东生物制药有限公司 Medical composition for treating rheumatoid arthritis and preparation method and quality control method thereof
CN101637591A (en) * 2008-08-01 2010-02-03 梁振兴 Medicinal composition with functions of strengthening tendons and bones and reviving joints and preparation method
CN101912536A (en) * 2010-07-29 2010-12-15 贾永全 Medicinal composition for treating rheumatism and rheumatoid disease

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1833700A (en) * 2005-03-17 2006-09-20 乔德松 Medicinal compsns. for treating rheumatism and rheumatoid arthritis and its prepn. method
CN101129697A (en) * 2007-08-23 2008-02-27 于春杰 Orally taken traditional Chinese medicine composition for treating atrophic arthritis
CN101530566A (en) * 2008-03-10 2009-09-16 王林祥 Drug for treating rheumatism and rheumatoid disease
CN101569682A (en) * 2008-04-29 2009-11-04 北京亚东生物制药有限公司 Medical composition for treating rheumatoid arthritis and preparation method and quality control method thereof
CN101637591A (en) * 2008-08-01 2010-02-03 梁振兴 Medicinal composition with functions of strengthening tendons and bones and reviving joints and preparation method
CN101912536A (en) * 2010-07-29 2010-12-15 贾永全 Medicinal composition for treating rheumatism and rheumatoid disease

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