CN102430018A - Medicinal composition for treating rheumatic and rheumatoid arthritis - Google Patents
Medicinal composition for treating rheumatic and rheumatoid arthritis Download PDFInfo
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- CN102430018A CN102430018A CN201110382506XA CN201110382506A CN102430018A CN 102430018 A CN102430018 A CN 102430018A CN 201110382506X A CN201110382506X A CN 201110382506XA CN 201110382506 A CN201110382506 A CN 201110382506A CN 102430018 A CN102430018 A CN 102430018A
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Abstract
The invention discloses a medicinal composition for treating rheumatic and rheumatoid arthritis. The composition consists of twig and leaf of common tupidanthus, pangolin, Fructus evodiae, realgar, long-noded pit viper, angelica, Drynaria rhizome, grassleaf sweelflag rhizome, Chinese starjasmine stem, clematis root, epimedium herb, Fructus liquidambaris, rhubarb, centipede, scorpion, clove and entadae stem. The medicinal composition is prepared into clinically acceptable emplastrum, ointment, pressurized spray, liniment or tincture by adding the conventional auxiliary materials according to the conventional process. The medicinal composition has the effects of expelling pathogenic wind and removing moisture, subsiding swelling and relieving pain, promoting blood circulation and removing blood stasis, warming meridians and unblocking collaterals. The medicinal composition has obvious effect and has no toxic or side effect on the treatment of the rheumatic and rheumatoid arthritis.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition of treating rheumatism and rheumatoid arthritis.
Background technology
Rheumatism belongs to one type of arthromyodynia, " so-called numbness person, each with reinfection at that time in the wet gas of wind and cold also "; The cause of disease of disadvantage is a lot, but nothing more than exopathogenic factor and endogenous cause of ill.Brilliantly point out in " element is asked the numbness opinion ": " wet three gas of wind and cold are assorted extremely, close and are numbness ... ".Modern medicine then think rheumatismal pathogenic factors except that wind, cold, wet, also comprise infection, immunity, metabolism, endocrine, degeneration, heredity, tumor etc.
Rheumatism and rheumatoid arthritis, the traditional Chinese medical science are thought the disease due to wind and the wet two kinds of pathogenic factor combination.Disease opinion has headache, heating, slight perspiration, aversion to wind, heavy sensation of the body, dysuria, joint to ache, can not bend and stretch etc.Arthropathy still with swelling and moving obstacle, is outbreak and alleviates the alternative chronic course of disease except that pain is arranged.Because patient's blood circulation is obstructed; Cause muscle or organize needed nutrition to carry through blood circulation; Cause patient's muscle to lack nutrition and accelerated ageing becomes stiff; Serious meeting causes patient's muscle and blood vessel atrophy, part patient and the joint can occur and disable depleted with viscera function.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition of treating rheumatism and rheumatoid arthritis.
The present invention realizes through following technical scheme:
The crude drug of pharmaceutical composition of the present invention consists of:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Pharmaceutical composition of the present invention adds conventional adjuvant according to common process and processes the emplastrum of clinical acceptance, ointment, spray, liniment or tincture.
Pharmaceutical composition of the present invention has the effect of evil-wind expelling and dampness removing, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian.To treatment rheumatism and rheumatoid arthritis with remarkable effect, have no side effect.
Following experimental example is used to further specify the present invention, but is not limited to the present invention.
One, experimental example
1, clinical observation
Treatment group anthology invention emplastrum (according to the preparation of embodiment 1 method) treatment rheumatism and rheumatoid arthritis 100 examples, male's 50 examples wherein, women's 50 examples.
Matched group selects bones and muscles pain to paste, and is produced treatment rheumatism and rheumatoid arthritis 100 examples, male's 50 examples wherein, women's 50 examples by Henan Province's space health scientific research company limited.
2, medicament selection
The treatment group: emplastrum of the present invention (according to the preparation of embodiment 1 method), treat three courses of treatment (12 days one courses of treatment), one pasted/2 days.
Matched group: bones and muscles pain pastes, and is produced by Henan Province's space health scientific research company limited, treats three courses of treatment (12 days one courses of treatment), and one pasted/2 days.
3, diagnostic criteria
1. medical history: the invasion and attack history that wind-cold damp pathogen is arranged.
2. symptom: joint or muscular soreness are arranged, numb, pain.Even severe pain, difficulty: meet the cold state of an illness and increase the weight of.
3. sign: the joint of getting involved is because of function limitation due to the pain, but alleviates after the activity, and most cases are the pain pneumonedema only, the minority case in the joint around mild swelling (no red heat).
4. x ray examination: except that the visible soft tissue swelling of minority case, generally do not have sclerotin change.
5. lab testing: erythrocyte sedimentation rate is most normal.Minority is fast slightly: antistreptolysin O (ASO), rheumatoid factor, routine blood test etc. all belong to normally.
6. prognosis: deformity is not stayed in the joint of getting involved after catabasis or the healing, and joint function recovery is normal.
4, criterion of therapeutical effect
" in cure the desease diagnosis criterion of therapeutical effect " with reference to State Administration of Traditional Chinese Medicine 1994 implements drafts as follows:
Recovery from illness: tcm clinical practice symptom, sign disappear or basic the disappearance;
Produce effects: tcm clinical practice symptom, sign obviously change;
Effectively: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign all do not have obvious improvement;
5, therapeutic outcome
The Comparison of therapeutic of table 1 treatment rheumatism and rheumatoid arthritis
| Group | The treatment number | Cure | Produce effects | Effectively | Invalid | Total effective rate |
| The treatment group | 100 | 40 | 29 | 28 | 3 | 97％ |
| Matched group | 100 | 31 | 22 | 30 | 17 | 83％ |
6, conclusion
Treatment group and matched group are treated three courses of treatment (12 days each courses of treatment) respectively, and the treatment group loses money in a business and invents emplastrum (according to the preparation of embodiment 1 method), and matched group pastes bones and muscles pain and pastes, and is produced by Henan Province's space health scientific research company limited.Therapeutic outcome shows, treatment group total effective rate 97% of the present invention, matched group total effective rate 83%.Treatment group of the present invention obviously is superior to matched group.
7, discuss
The Ramulus et Folium Tupidanthi celyptrati source is leaf, the stem of dicotyledon medicine Araliaceae Ramulus et Folium Tupidanthi celyptrati in the pharmaceutical composition of the present invention; Meridian distribution of property and flavor: hardship, temperature; Go into lung, kidney,liver,spleen four warps; Effect: relaxing muscles and tendons and activating QI and blood in the collateral, the circulation of qi promoting damp eliminating, cold expelling dispels the wind, eliminating dampness to stop diarrhea.Cure mainly: be used for traumatic injury, fracture pain person, the arthralgia aggravated by cold of cold and damp stagnation, affection of exogenous wind-cold, heating fear of cold, head-body-pain; Be used for distension and fullness in the abdomen, malaise, anorexia, poor appetite, dysentery person.Squama Manis medical material Ji Yuan: be the scale of Manidae animal Manitis; Salty in the mouth; Cold nature; Return liver, the stomach warp.The Fructus Evodiae source is the almost ripe fruit of rutaceae Fructus Evodiae; Nature and flavor: hot in nature, acrid in the mouth, hardship; Slightly poisonous.Return liver, spleen, stomach, kidney channel; Function cures mainly: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal; Be used for headache, colic, beriberi, dysmenorrhea, abdominal distention, vomiting acid regurgitation, aphtha.Realgar is hot, temperature; Poisonous; Return liver, large intestine channel; Function cures mainly: detoxifcation parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria.Agkistrodon: for Agkistrodon halys section animal point is kissed the dry all of Pallas pit viper (Agkistrodon); Sweet, salty, temperature; Poisonous; Return Liver Channel; Function cures mainly: dispel the wind collateral dredging, relieving convulsion; Be used for rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, malignant boil.Radix Angelicae Sinensis, warm in nature, sweet in the mouth, suffering; Return liver, the heart, spleen channel; Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Rhizoma Drynariae is the dry rhizome of Polypodiaceae plant Mongolian oak Herba pteridii latiusculi; Hardship, temperature; Return kidney, Liver Channel; Function cures mainly: the kidney invigorating bone strengthening continues and hinders pain relieving; Be used for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, and the muscles and bones folding is hindered; The external treatment alopecia areata, Rhizoma Acori Graminei belongs to Acoraceae; Suffering, temperature; GUIXIN, the stomach warp; Function cures mainly: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae; It is not hungry to be used for the gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Caulis Trachelospermi is the leaf bine stem of apocynaceae plant trachelospermum jasminoide; Hardship is slightly cold; GUIXIN, liver, kidney channel; Function cures mainly: dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence; Be used for the rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.The Radix Clematidis suffering is salty, and temperature is poisonous; Go into lung, kidney two warps; Has expelling wind and removing dampness, dredge the meridian passage, diuresis, pain relieving effect; Cure mainly rheumatic ostalgia, jaundice, edema, dysuria, migraine, internal traumatic injury.Herba Epimedii is hot, sweet, temperature; Return liver, kidney channel; Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.Fructus Liquidambaris is the dry mature fruit of Hamamelidaceae plant Chinese sweet gum; Hardship, flat; Return liver, kidney channel; Function cures mainly: dispelling, collateral-activating, and diuretic stimulates the menstrual flow; Be used for arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.Radix Et Rhizoma Rhei be multiple Polygonaceae Rheum perennial plant close title, hardship, cold; Return the stomach warp, large intestine channel, Liver Channel, spleen channel; Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation.Scolopendra is warm in nature, and acrid in the mouth is poisonous; Return liver, spleen, lung meridian; Function with endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Scorpio is hot, and is flat; Poisonous; Return Liver Channel; Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; Be used for infantile convulsion, the tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection.Flos Caryophylli is a Myrtaceae syzygium species plant Flos Caryophylli; Suffering, temperature; Effect: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI; Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.Caulis Entadae is the herb or the spore of lycopsid bar helictite; Hot; Temperature; Bitter; Return liver; Urinary bladder channel; Cure mainly expelling wind and dampness; Relaxing muscles and tendons and activating QI and blood in the collateral; Eliminating stasis to stop pain; Diuresis; The main air pain of dampness syndrome; Numb hand and foot; Traumatic injury; Menoxenia.All medicine merging have the effect of evil-wind expelling and dampness removing, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian.To treatment rheumatism and rheumatoid arthritis with remarkable effect, have no side effect.
Experimental example two, model case
Case 1: Wang, woman, 53 years old.Symptom: do not have obvious inducement winter in 2008 and whole body the. fugitive arthralgia occurs, to the local chemical examination RF+ of hospital, be diagnosed as rheumatoid arthritis, give Radix Tripterygii Wilfordii and extract oral poor effect, the back is to Beijing hospitalize, and effect is still bad.Winter in 2010, patient's interphalangeal joint pain increases the weight of and swelling occurs, bends and stretches difficulty, the slight degeneration in both hands thumb joint.The back is through losing money in a business three courses of treatment (12 days each courses of treatment) of invention emplastrum (according to embodiment 1 method preparation), and arthralgia is clearly better, and function of joint is obviously improved, and continues to use emplastrum of the present invention to recover normally basically on inspection three courses of treatment.
Case 2: Guo, woman, 55 years old.Symptom: double knee joint swelling pain 5 years, chemical examination erythrocyte sedimentation rate, anti-chain O are diagnosed as rheumatic arthritis.Oral administration antiinflammatory, analgesic drug product treatment 2 years, poor effect, dead point penicillin treatment first quarter moon has little effect again, oral again rheumatism Chinese medicine decoction treatment 2 years, effect is also undesirable, also once does the Chinese medicine infiltration and adds the diathermy treatment, also to no effect.The back is introduced through others and is used ointment of the present invention (according to the preparation of embodiment 2 methods) to treat a course of treatment (12 days each courses of treatment); Symptom obviously alleviates; Continue to use the ointment of the present invention just can be free movable after two courses of treatment, be completely recovered after continuing to strengthen two courses of treatment of treatment again.
Case 3: Yang, man, 40 years old; People from Hefei, Anhui Province, symptom: the patient got rheumatoid arthritis in the time of 40 years old, and often arthralgia is stiff; Once took the treatment of plurality of Chinese and Western medicine ibuprofen anti-inflammatory analgetic, clothes back pain relief, but arthroncus; Regular heating, 38 ℃-39 ℃ of body temperature.Both hands foods, in, thumb moderate distortion, two elbow joinies swell and ache not tensible.Red tongue, greasy fur, health is become thin.Blood picture: leukocyte 8000, erythrocyte 3,800,000, platelet 340,000, erythrocyte sedimentation rate 45RE+.Use spray of the present invention (according to embodiment 3 methods preparations) after two courses of treatment, arthralgia alleviates, and subjective symptoms takes a turn for the better.Use two courses of treatment with continued, the swollen joint pain disappears, and dysfunction is significantly improved.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 emplastrum
Said medicine is added conventional adjuvant according to common process process emplastrum, one pasted/2 days.
Embodiment 2 ointments
Said medicine is added conventional adjuvant according to common process process ointment.
Embodiment 3 sprays
Said medicine is added conventional adjuvant according to common process process spray.
Embodiment 4 liniments
Said medicine is added conventional adjuvant according to common process process liniment.
Embodiment 5 tinctures
Said medicine is added conventional adjuvant according to common process process tincture.
Claims (6)
1. a pharmaceutical composition of treating rheumatism and rheumatoid arthritis is characterized in that, the crude drug of said composition consists of:
2. pharmaceutical composition as claimed in claim 1 is characterized in that, the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1 is characterized in that, the crude drug of this pharmaceutical composition consists of:
4. pharmaceutical composition as claimed in claim 1 is characterized in that, the crude drug of this pharmaceutical composition consists of:
5. like the described pharmaceutical composition of one of claim 1-4, it is characterized in that this pharmaceutical composition adds conventional adjuvant according to common process and processes the emplastrum of clinical acceptance, ointment, spray, liniment or tincture.
6. like the application of the described pharmaceutical composition of one of claim 1-4 in the medicine of preparation treatment rheumatism and rheumatoid arthritis.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110382506XA CN102430018B (en) | 2011-11-28 | 2011-11-28 | Medicinal composition for treating rheumatic and rheumatoid arthritis |
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| CN201110382506XA CN102430018B (en) | 2011-11-28 | 2011-11-28 | Medicinal composition for treating rheumatic and rheumatoid arthritis |
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| CN102430018B CN102430018B (en) | 2013-06-05 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836243A (en) * | 2012-08-25 | 2012-12-26 | 李新欣 | Traditional Chinese medicine for cure of rheumatoid arthritis |
| CN105031519A (en) * | 2015-07-08 | 2015-11-11 | 济南方宇文化传媒有限公司 | Arthritis-treatment traditional Chinese medicine external application preparation and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1833700A (en) * | 2005-03-17 | 2006-09-20 | 乔德松 | Medicinal compsns. for treating rheumatism and rheumatoid arthritis and its prepn. method |
| CN101129697A (en) * | 2007-08-23 | 2008-02-27 | 于春杰 | Orally taken traditional Chinese medicine composition for treating atrophic arthritis |
| CN101530566A (en) * | 2008-03-10 | 2009-09-16 | 王林祥 | Drug for treating rheumatism and rheumatoid disease |
| CN101569682A (en) * | 2008-04-29 | 2009-11-04 | 北京亚东生物制药有限公司 | Medical composition for treating rheumatoid arthritis and preparation method and quality control method thereof |
| CN101637591A (en) * | 2008-08-01 | 2010-02-03 | 梁振兴 | Medicinal composition with functions of strengthening tendons and bones and reviving joints and preparation method |
| CN101912536A (en) * | 2010-07-29 | 2010-12-15 | 贾永全 | Medicinal composition for treating rheumatism and rheumatoid disease |
-
2011
- 2011-11-28 CN CN201110382506XA patent/CN102430018B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1833700A (en) * | 2005-03-17 | 2006-09-20 | 乔德松 | Medicinal compsns. for treating rheumatism and rheumatoid arthritis and its prepn. method |
| CN101129697A (en) * | 2007-08-23 | 2008-02-27 | 于春杰 | Orally taken traditional Chinese medicine composition for treating atrophic arthritis |
| CN101530566A (en) * | 2008-03-10 | 2009-09-16 | 王林祥 | Drug for treating rheumatism and rheumatoid disease |
| CN101569682A (en) * | 2008-04-29 | 2009-11-04 | 北京亚东生物制药有限公司 | Medical composition for treating rheumatoid arthritis and preparation method and quality control method thereof |
| CN101637591A (en) * | 2008-08-01 | 2010-02-03 | 梁振兴 | Medicinal composition with functions of strengthening tendons and bones and reviving joints and preparation method |
| CN101912536A (en) * | 2010-07-29 | 2010-12-15 | 贾永全 | Medicinal composition for treating rheumatism and rheumatoid disease |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836243A (en) * | 2012-08-25 | 2012-12-26 | 李新欣 | Traditional Chinese medicine for cure of rheumatoid arthritis |
| CN105031519A (en) * | 2015-07-08 | 2015-11-11 | 济南方宇文化传媒有限公司 | Arthritis-treatment traditional Chinese medicine external application preparation and preparation method thereof |
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| CN102430018B (en) | 2013-06-05 |
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