CN102872252B - Medicinal composition for treating rheumatic pain - Google Patents
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Abstract
The invention discloses a medicinal composition for treating rheumatic pain. The composition consists of kadsura pepper stem, angelica dahurica, clematis root, Chinese starjasmine stem, asafoetida, siegesbeckia, musk, willow branch, loose knot, bark of Chinese redbud, fructus gleditsiae, ligusticum, mylabris, daphne genkwa and flowering rush butomus. The medicinal composition is prepared into clinically acceptable paste, spray, ointment, liniment or tincture by adding conventional auxiliary materials according to the conventional process. The medicinal composition has the effects of warming and activating meridian, promoting blood circulation to remove blood stasis, relieving swelling and pain and removing wind and damp, has a good treatment effect of treating the rheumatic pain, and does not have toxic or side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of rheumatalgia.
Background technology
Rheumatalgia, its disease belongs to paralysis one class, and the traditional Chinese medical science is thought the disease due to wind and wet two kinds of pathogenic factor combination.Disease opinion has headache, heating, slight perspiration, aversion to wind, heavy sensation of the body, dysuria, joint to ache, can not bend and stretch etc.Arthropathy, is outbreak and alleviates the chronic course of disease alternately outward still with swelling and moving obstacle apart from pain.Because patient's blood circulation is obstructed, cause muscle or organize needed nutrition to carry by blood circulation, cause patient's muscle to lack nutrition and accelerated ageing becomes stiff, serious meeting causes patient's muscle and blood vessel atrophy, some patients were and can occur that joint disables and viscera function exhaustion.Bi condition is to wait exopathogen invasion because wind and cold is damp and hot, impatency meridians joint, QI-blood circulation is not smooth, main clinical manifestation be whole body joint be migration red, swell, weighing, pain.Often refer to rheumatic arthritis.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of rheumatalgia.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The raw material composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention can also be:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Pharmaceutical composition of the present invention adds conventional adjuvant to make the emplastrum of clinical acceptance, spray, ointment, liniment or tincture according to common process.
Pharmaceutical composition of the present invention has promoting the flow of QI in the collateral by warming the meridian, and effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, evil-wind expelling and dampness removing has good therapeutical effect to treatment rheumatalgia, and has no side effect.
Experimental example is used for further illustrating the present invention below, but is not limited to the present invention.
One, experimental example
1, clinical observation
Emplastrum of the present invention (according to embodiment 1 method preparation) treatment rheumatalgia 100 examples, wherein male's 50 examples, women's 50 examples.
Select matched group treating rheumatism and strengthening bone to paste, by Zhengzhou, Hui Zhengtang Pharmaceutical Technology Co., Ltd produces, treatment rheumatalgia 100 examples, wherein male's 50 examples, women's 50 examples.
2, medicament selection
Treatment group: emplastrum of the present invention (according to embodiment 1 method preparation), 30g/ pastes, and one pastes/2 days.
Matched group: rheumatic ostalgia pastes, Yongchun, effluent south medicine company limited produces, and one pastes/2 days.
3, diagnostic criteria
1. medical history: the invasion and attack history that has wind-cold damp pathogen.
2. symptom: there are joint or muscular soreness, numb, pain, even severe pain, movable difficulty, meets cold aggravation.
3. sign: the joint of getting involved is because of function limitation due to pain, but alleviate after activity, majority of cases is pain pneumonedema only, and minority case is in periarticular mild swelling (without red heat).
4. x ray examination: except the visible soft tissue swelling of minority case, generally without sclerotin change.
5. lab testing: erythrocyte sedimentation rate is most normal, and minority is slightly fast, and it is normal that antistreptolysin 0, rheumatoid factor, routine blood test etc. all belong to.
6. prognosis: deformity is not stayed in the joint of getting involved after catabasis or healing, and joint function recovery is normal.
4, criterion of therapeutical effect
" in cure the desease Standardization of diagnosis and curative effect " of implementing with reference to State Administration of Traditional Chinese Medicine 1994 drafted as follows:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear;
Effective: tcm clinical practice symptom, sign obviously change;
Effective: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all not improved;
5, therapeutic outcome
Table 1 is treated the Comparison of therapeutic of rheumatalgia
| Group | Treatment number | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 100 | 65 | 20 | 13 | 2 | 98％ |
| Matched group | 100 | 58 | 13 | 10 | 19 | 81％ |
6, conclusion
Treatment group and matched group stick respectively three courses for the treatment of (12 days each courses for the treatment of), the treatment group invention emplastrum (according to embodiment 1 method preparation) that loses money in a business, and matched group pastes rheumatic ostalgia and pastes.Therapeutic outcome shows, treatment group total effective rate 98% of the present invention, matched group total effective rate 81%.Treatment group of the present invention is obviously better than matched group.
7, discuss
Caulis Piperis Kadsurae in pharmaceutical composition of the present invention: the dry rattan of Piperaceae plant Radix seu Caulis fici Martinii.Pungent, bitter, tepor.Return Liver Channel.Effect is the temperature of dispeling the wind, the meridian dredging.Can treat for anemofrigid-damp arthralgia articular instability, lumbocrural pain, the contracture of muscle arteries and veins.Lung cold is breathed with cough, joint stuffiness." Zhejiang Chinese medicine handbook ": a surname's numbness, removing dampness, Tongluo Shujin.Control lower limb knee joint flaccidity syndrome and arthralgia syndrome, arthralgia.The Radix Angelicae Dahuricae: meridian distribution of property and flavor; Pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the wind of the skin migration of dispelling, the only cold pain of the cold stomachache of stomach, whole body cold-damp pain.Radix Clematidis: Xin Xian, temperature, poisonous.Gui Jing: enter urinary bladder channel.Function: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly: gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Caulis Trachelospermi: be the leaf bine stem of apocynaceae plant trachelospermum jasminoide.Cold nature, bitter in the mouth.Dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence.For rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down." Jiangxi medical herbs ": dispelling, collateral-activating, cooling blood for hemostasis.Curing arthritis.Resina Ferulae acrid in the mouth, temperature, enter liver, spleen, stomach warp.Have the detumescence of regulating the flow of vital energy, invigorate blood circulation disappear tired, eliminate the phlegm and effect of excitor nerve.Herba Siegesbeckiae: meridian distribution of property and flavor: cold, pungent, bitter, Liver Channel, kidney channel.Function: wind-damp dispelling, sharp joint, removing toxic substances.Cure mainly:, soreness of the waist and knees unable for rheumatic arthralgia, muscles and bones, quadriplegia, hemiplegia, rubella eczema." detailed outline ": " treating the liver the kidney-wind syndrome gas, quadriplegia, a little less than osteodynia knee joint, all skin ulcers of rheumatism." secretions of glandular sac between Moschus be male Moschus moschiferous umbilicus and genitals, be graininess or bulk after dry.Pungent, temperature, GUIXIN, spleen channel.Function cures mainly: the refreshment of having one's ideas straightened out, and promoting blood circulation to restore menstrual flow, pain relieving, hastens parturition." Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House ": can change the logical pancreas reason of sun.Can thoroughly reach by priming." detailed outline ": logical all keys, open meridians, thoroughly flesh bone.Ramulus Salicis Babylonicae: hardship, cold.Effect: dispel the wind, diuresis, pain relieving, detumescence." must join book on Chinese herbal medicine ": go wind heat, except arthralgia chiefly caused by damp pathogen.Resina Ferulae: the medical material that is a kind of uniqueness in Xinjiang.Perennial once result draft.Lignum Pini Nodi: meridian distribution of property and flavor is bitter, and temperature, returns Liver Channel.Effect is dispeiling pathogenic wind and removing dampness, pain relieving.For main anemofrigid-damp arthralgia, severe and migratory arthralgia pain; Foot numbness flaccidity is soft; Traumatic pain.Cortex cercis chinensis: be the bark of leguminous plant cercis.Warm in nature, acrid in the mouth hardship, poisonous.Enter liver, spleen two warps.Function cures mainly: promoting blood circulation to restore menstrual flow, subduing swelling and detoxicating.Control anemofrigid-damp arthralgia, women's amenorrhea, vim and vigour pain, sore throat, drenches disease, carbuncle." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control bones and muscles pain, anemofrigid-damp arthralgia, apathy, paralysis flaccidity is soft, warm muscle, only lumbago, controls married woman's cold in blood stomachache." " detailed outline ": " blood-activating and qi-promoting, subduing swelling and detoxicating." Fructus Gleditsiae Abnormalis: Xin Xian, temperature, poisonous.Enter lung, stomach, large intestine channel.Function cures mainly: sensible, clearing away phlegm, searches wind.Control apoplexy locked mouth, wind syndrome of head, wind is chronic, sore throat, phlegm dyspnea, feeling of fullness is stagnant, and obstruction and rejection is obstructed, carbuncle, mange, tinea disease." property of medicine opinion ": main broken hard disease, abdominal pain, can have an abortion.Fructus Gleditsia, in wine, is exhausted to its essence, and the one-tenth cream of decocting, is coated with silks, pastes all toxic swellings, the double pain that can relieve the pain.Rhizoma Ligustici: the dry rhizome of samphire Rhizoma Ligustici or Rhizoma Ligustici and root.Pungent, temperature.Return urinary bladder channel.Function cures mainly: dispels the wind, and cold expelling, dehumidifying, pain relieving.For anemofrigid cold, top, mountain peak pain, rheumatism podomere arthralgia pain." book on Chinese herbal medicine just ": " treat rheumatism and have loose bowels, acute infantile convulsion mist reveals miasma epidemic disease." " book on Chinese herbal medicine is new again ": " dispelling the wind and dampness pathogens sufferings, wind syndrome of head order is swollen, the malaria of having loose bowels dysentery." Mylabris: acrid in the mouth; Warm in nature; Large poison.Enter large intestine, small intestinal, liver, kidney channel.Function cures mainly: counteracting toxic substances phagedenoma; Removing blood stasis eliminating stagnation.Main carbuncle; Scrofula; Stubborn dermatitis; Amenorrhea; Lump in the abdomen; Cancerous protuberance." property of medicine opinion ": control scrofula, tonneau water channel.Moschus: Flos Genkwa: root bark: pungent, bitter, flat.Poisonous.Function cures mainly: subduing swelling and detoxicating, promoting blood circulation and stopping pain." property of medicine opinion ": " main promoting blood circulation, controls malignant boil migratory arthralgia wet, all malicious wind, and extremity contraction is anxious, can not go step, can removing water retention by purgation swelling expire.”。CAOXIE: property is flat, bitter in the mouth.Enter Liver Channel, stomach warp, urinary bladder channel.Function: dampness removing goes turbid, blood stasis dispelling dispels the wind.Dampness removing goes turbid, wind expelling stagnation removing." herbal classic ": main lumbago and backache, bone strengthening joint, wind and cold wetted perimeter numbness, malignant boil is recover not, steam.The all medicine merging of crude drug of the present invention have promoting the flow of QI in the collateral by warming the meridian, and blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, evil-wind expelling and dampness removing, have good therapeutical effect to treatment rheumatalgia, and have no side effect.
Experimental example two, model case
Case 1: Wang, female, 11 years old.Patient usually body constitution is poor, is easy to flu, after suffering from cold, occurs that bilateral refers to that between (toe), joint symmetry swells and ache before 2 months, companion's deadlock in morning more than 2 hours, and aversion to cold and preference for warmth, weak.Body of the tongue is light red partially dark, white and thin fur, and deep-thready pulse is string slightly.Western medicine diagnose: juvenile rheumatoid arthritis.Tcm diagnosis: rheumatoid arthritis, the cold card of containing of suffering from a deficiency of the kidney.Dialectical: wind and cold heat-transformation, with the passing of time impairment of YIN.Method for the treatment of: the kidney invigorating cold expelling, expelling wind and removing dampness.By the invention emplastrum that loses money in a business (according to embodiment 1 method preparation), one pastes/2 days.Treat three courses for the treatment of (12 days per courses for the treatment of), each arthralgia symptom obviously alleviates, and morning, deadlock was less than half an hour, and the state of an illness is clearly better.When further consultation, tongue arteries and veins is the same.Three courses for the treatment of of continuous docile and obedient invention plaster, arthralgia is alleviated, and function of joint is obviously improved.After continuing to strengthen two courses for the treatment of, cure completely.
Case 2: high certain, female, 60 years old.Main suit's multi-joint pain 30 years repeatedly, increases the weight of 1 month.There is double knee joint and heel pain without obvious inducement before 30 years in patient, without swelling, examines as RA in outer court, gives analgesic treatment, and symptom is shown effect repeatedly, aggravation before 1 month.Inscribe: the nearly articulations digitorum manus of left hand the 2nd, 3 swells and ache, two wrists, both shoulders pain, double knee joint swells and ache.Xerostomia, without oral ulcer and erythra, without Raynaud phenomenon, conscious aversion to cold and cold limbs, aversion to wind, poor appetite, dormancy can, two just be adjusted.Have a medical check-up: left hand the 2nd, 3 proximal interphalangeal joint swelling, tenderness are obvious, local Pi Wengao, left elbow flexing is limited, and two knee joints stretch difficulty, attach most importance to right side.The dark yellow fur of tongue, slippery and rapid pulse.Western medicine diagnose: rheumatoid arthritis.Tcm diagnosis: arthromyodynia, it is damp and hot that card belongs to the deficiency of vital energy, obstruction of collaterals by blood stasis.Method for the treatment of: functions dispelling wind and clearing away cold, removing dampness, dissipating phlegm and eliminating blood stasis.The application of the invention ointment (according to embodiment 2 methods preparations) treatment four courses for the treatment of (12 days each courses for the treatment of), patient is conscious, and whole body arthralgia is clearly better, and receives food amelioration, the peace of sleeping, hands can write, and can freely walk.Continue to use two courses for the treatment of of ointment of the present invention, patient's pain disappears substantially, and swelling disappears entirely, and activity freely.After continuing to strengthen three courses for the treatment of, cure completely.
Case 3: Wang, female is 35 years old, married.There is the little arthralgia of both hands after experiencing cold-damp before half a year in patient, certainly takes after medicinal liquor for rheumatism, and symptom increases the weight of.Like at ordinary times cold.Interphalangeal joint congestion and swelling pain, local pyrexia, obtains cool alleviation of pain, limitation of activity, hands can not be held and take the photograph, stiff 3 hours of morning, feeling thirst but no desire to drink, yellow urine is red.Red tongue, yellow fur is micro-greasy, slippery and rapid pulse.Western medicine diagnose: rheumatoid arthritis; Tcm diagnosis: arthromyodynia; Dialectical: pyretic toxicity folder is wet, numbness resistance venation.Method for the treatment of: heat-clearing and toxic substances removing, dampness removing a surname numbness, promoting blood circulation to remove obstruction in the collateral.The application of the invention spray (according to embodiment 3 method preparations) treatment two courses for the treatment of (12 days each courses for the treatment of), arthralgia is clearly better, function of joint is obviously improved, and life course for the treatment of of continual cure can be taken care of oneself completely, substantially recovers on inspection normal.
Case 4: Lee, man, 55 years old.Patient main suit's arthralgia is interrupted outbreak 2 years, within nearly 1 year, increases the weight of.Just after cause upper respiratory tract infection, occur heating, joint, whole body distending pain alleviates after western medical treatment, but still the arthralgia that repeatedly shows effect, involve bilateral refer between, the palm refers to, wrist, toes, ankle, knee joint, swelling pain, all night unable to fall asleep, be once diagnosed as rheumatoid arthritis in outer court.When medical, disease is seen: both hands proximal interphalangeal joint, left side toes joint congestion and swelling pain, two wrists, double knee joint pain, limitation of activity, can not hold thing, can not squat down, morning deadlock, difficulty in walking (need to assist in), anemophobia is afraid of cold.Red tongue yellow and thin fur, stringy and thready pulse.Western medicine diagnose: rheumatoid arthritis active stage; Tcm diagnosis: rheumatism involving the bone; Dialectical: wind and cold heat-transformation, with the passing of time impairment of YIN.Method for the treatment of: clearing away heat and nourishing YIN, reducing swelling and alleviating pain, dispelling wind and removing obstruction in the collateral.After the course for the treatment of of the application of the invention emplastrum (according to embodiment 4 methods preparations), (12 days courses for the treatment of) each arthralgia symptom obviously alleviates, and can go to sleep peacefully night, and aversion to wind is afraid of cold and is alleviated, and walking comes to go to a doctor alone.When further consultation, still swelling is obvious in joint, and both hands can not be clenched fist, and tongue arteries and veins is the same.Continue to use two courses for the treatment of, arthralgia is alleviated, and function of joint is obviously improved, can autonomic activities, be completely recovered after using again after treatment 1 course for the treatment of.
Case 5: Zhang, female, 50 years old, workman.Nineteen ninety-five is diagnosed as rheumatoid arthritis.The little arthralgia swelling of both hands joint stuffiness when medical.It is obvious that play ankylosis morning, movable rear improvement.Finger is fusiformis swelling, and metacarpophalangeal joints is ulnar deviation deformity, and dysfunction can not be adhered to teaching, and life can not be taken care of oneself completely.The application of the invention ointment (according to embodiment 5 method preparations) treatment two courses for the treatment of (12 days course for the treatment of), arthralgia is clearly better, function of joint is obviously improved, and two lives course for the treatment of of continual cure can be taken care of oneself completely, substantially recover on inspection normal.
Case 6: week certain, female, 45 years old.Patient starts to occur bilateral bilateral articulations digitorum manus symmetry pain the year before, Relapse rate outbreak, time heavy when light, nearly two weeks carrys out aggravation, and the little joint of extremity symmetry red and swollen heat pain when medical, taking bilateral articulations digitorum manus and bilateral knee arthralgia as main, joint stuffiness, movable difficulty.Joint obtains cold easypro, and pain can not be touched, and plays ankylosis morning, after activity, take a turn for the better to some extent, and the heat that occurs together, aversion to wind, thirsty.Diagnostics classes rheumatic arthritis (wind heat arthralgia chiefly caused by damp pathogen type).The application of the invention liniment is (according to embodiment 6 method preparations, every day 2 times) treatment, after the course for the treatment of (12 days course for the treatment of), symptom obviously alleviates, and continues to use three courses for the treatment of, just can be freely movable, be completely recovered after using again the after treatment course for the treatment of.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 emplastrum
Add conventional adjuvant to make emplastrum according to common process said medicine, 30g/ pastes, 2 days/paste.
Embodiment 2 ointments
Add conventional adjuvant to make ointment according to common process said medicine, every day 2 times.
Embodiment 3 sprays
Add conventional adjuvant to make spray according to common process said medicine.
Embodiment 4 emplastrumes
Add conventional adjuvant to make emplastrum according to common process said medicine.
Embodiment 5 ointments
Add conventional adjuvant to make emplastrum according to common process said medicine, 30g/ pastes, 2 days/paste.
Embodiment 6 liniments
Add conventional adjuvant to make liniment according to common process said medicine.
Embodiment 7 tinctures
Add conventional adjuvant to make tincture according to common process said medicine.
Claims (8)
1. treat a pharmaceutical composition for rheumatalgia,, it is characterized in that, the crude drug of this pharmaceutical composition consists of:
2. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
4. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
5. the pharmaceutical composition as described in one of claim 1-4, is characterized in that this pharmaceutical composition adds conventional adjuvant to make the emplastrum of clinical acceptance, spray or ointment according to common process.
6. the pharmaceutical composition as described in one of claim 1-4, is characterized in that this pharmaceutical composition adds conventional adjuvant to make the liniment of clinical acceptance according to common process.
7. the pharmaceutical composition as described in one of claim 1-4, is characterized in that this pharmaceutical composition adds conventional adjuvant to make the tincture of clinical acceptance according to common process.
8. the application of the pharmaceutical composition as described in one of claim 1-4 in the medicine of preparation treatment rheumatalgia.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1190014A (en) * | 1998-02-17 | 1998-08-12 | 刘煌清 | Medicine for hemiplegia |
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