CN102861195B - Drug composition for treating rheumatism pain - Google Patents
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Abstract
The invention discloses a drug composition for treating rheumatism pain. The composition consists of yam rhizome, venenum bufonis, manyleaf paris rhizome, monkey bezoar, leopard bone, loose knot, caulis trachelospermi, fructus gleditsiae, folium photiniae, centipede, sangusis draconis, geranium wilfordii, flos genkwa and methyl salicylate. Conventional auxiliary materials are added in the drug composition by a regular technology to prepare into clinically accepted emplastrum, nebula, ointment, liniment or tincture. The drug composition has the functions of warming and activating meridian, promoting circulation and removing stasis, relieving swelling and pain and ridding dampness, has good treatment effect on rheumatism pain, and has no toxic or side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of rheumatalgia.
Background technology
Rheumatalgia, its disease belongs to paralysis one class, and the traditional Chinese medical science is thought the disease due to wind and wet two kinds of pathogenic factor combination.Disease opinion has headache, heating, slight perspiration, aversion to wind, heavy sensation of the body, dysuria, joint to ache, can not bend and stretch etc.Arthropathy, is outbreak and alleviates the chronic course of disease alternately outward still with swelling and moving obstacle apart from pain.Because patient's blood circulation is obstructed, cause muscle or organize needed nutrition to carry by blood circulation, cause patient's muscle to lack nutrition and accelerated ageing becomes stiff, serious meeting causes patient's muscle and blood vessel atrophy, some patients were and can occur that joint disables and viscera function exhaustion.Bi condition is because wind and cold is damp and hot, to wait exopathogen invasion, impatency meridians joint, QI-blood circulation is not smooth, main clinical manifestation be whole body joint be migration red, swell, weighing, pain.Often refer to rheumatic arthritis.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of rheumatalgia.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Lignum Pini Nodi 5-15 weight portion Caulis Trachelospermi 5-15 weight portion Fructus Gleditsiae Abnormalis 5-15 weight portion
Folium Photiniae (Folium Photiniae serrulatae) 5-15 weight portion Scolopendra 5-15 weight portion Sanguis Draxonis 5-15 weight portion
Herba Erodii 5-15 weight portion.
The raw material composition of pharmaceutical composition of the present invention is preferably:
Lignum Pini Nodi 10 weight portion Caulis Trachelospermi 10 weight portion Fructus Gleditsiae Abnormalis 10 weight portions
Folium Photiniae (Folium Photiniae serrulatae) 10 weight portion Scolopendra 10 weight portion Sanguis Draxonis 10 weight portions
Herba Erodii 10 weight portions.
The raw material composition of pharmaceutical composition of the present invention is preferably:
Lignum Pini Nodi 7 weight portion Caulis Trachelospermi 13 weight portion Fructus Gleditsiae Abnormalis 7 weight portions
Folium Photiniae (Folium Photiniae serrulatae) 13 weight portion Scolopendra 7 weight portion Sanguis Draxonis 13 weight portions
Herba Erodii 7 weight portions.
The raw material composition of pharmaceutical composition of the present invention is preferably:
Lignum Pini Nodi 13 weight portion Caulis Trachelospermi 7 weight portion Fructus Gleditsiae Abnormalis 13 weight portions
Folium Photiniae (Folium Photiniae serrulatae) 7 weight portion Scolopendra 13 weight portion Sanguis Draxonis 7 weight portions
Herba Erodii 13 weight portions.
The crude drug of pharmaceutical composition of the present invention forms:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Pharmaceutical composition of the present invention adds conventional adjuvant to make the emplastrum of clinical acceptance, spray, ointment, liniment or tincture according to common process.
Pharmaceutical composition of the present invention has promoting the flow of QI in the collateral by warming the meridian, and blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, evil-wind expelling and dampness removing have good therapeutical effect to treatment rheumatalgia, and have no side effect.
Experimental example is used for further illustrating the present invention below, but is not limited to the present invention.
One, experimental example
1, clinical observation
Emplastrum of the present invention (according to embodiment 1 method preparation) treatment rheumatalgia 100 examples, male's 50 examples wherein, women's 50 examples.
Select matched group treating rheumatism and strengthening bone to paste, by Zhengzhou, Hui Zhengtang Pharmaceutical Technology Co., Ltd produces, treatment rheumatalgia 100 examples, male's 50 examples wherein, women's 50 examples.
2, medicament selection
Treatment group: emplastrum of the present invention (according to embodiment 1 method preparation), 25g/ pastes, and one pastes/2 days.
Matched group: rheumatic ostalgia pastes, Yongchun, effluent south medicine company limited produces, and one pastes/2 days.
3, diagnostic criteria
1. medical history: the invasion and attack history that has wind-cold damp pathogen.
2. symptom: there are joint or muscular soreness, numb, pain, severe pain even, movable difficulty, meets cold aggravation.
3. sign: the joint of getting involved is because of function limitation due to pain, but alleviate after activity, majority of cases is pain pneumonedema only, and minority case is in periarticular mild swelling (without red heat).
4. x ray examination: except the visible soft tissue swelling of minority case, generally without sclerotin change.
5. lab testing: erythrocyte sedimentation rate is most normal, and minority is slightly fast, and it is normal that antistreptolysin 0, rheumatoid factor, routine blood test etc. all belong to.
6. prognosis: deformity is not stayed in the joint of getting involved after catabasis or healing, and joint function recovery is normal.
4, criterion of therapeutical effect
The Standardization of diagnosis and curative effect > > that cures the desease in the < < implementing for 1994 with reference to State Administration of Traditional Chinese Medicine drafts as follows:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear;
Effective: tcm clinical practice symptom, sign obviously change;
Effective: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all not improved;
5, therapeutic outcome
The Comparison of therapeutic of table 1 treatment rheumatalgia
6, conclusion
Treatment group and matched group stick respectively three courses for the treatment of (12 days each courses for the treatment of), the treatment group invention emplastrum (according to embodiment 1 method preparation) that loses money in a business, and matched group pastes rheumatic ostalgia and pastes.Therapeutic outcome shows, treatment group total effective rate 97% of the present invention, matched group total effective rate 81%.Treatment group of the present invention is obviously better than matched group.
7, discuss
Pharmaceutical composition crude drug Zhong Rhizoma Dioscoreae Septemlobae of the present invention: property is flat, bitter in the mouth.Enter Liver Channel, stomach warp, urinary bladder channel.Function: dampness removing goes turbid, blood stasis dispelling dispels the wind.Dampness removing goes turbid, wind expelling stagnation removing., < < herbal classic > >: main lumbago and backache, bone strengthening joint, wind and cold wetted perimeter numbness, malignant boil is recover not, steam.Venenum Bufonis, sweet, acrid, warm, poisonous, function removing toxic substances, detumescence, pain relieving, < < book on Chinese herbal medicine converges says > >: " Venenum Bufonis, current twelve channels and collaterals, internal organs, pleurodiaphragmatic in terspace, joint Zhu Chu." " can dissolve the stagnant all diseases of the strongly fragrant heap soil or fertilizer over and around the roots of all stasis of bloods ".Rhizoma Paridis: toil, cold, poisonous.Enter the heart, Liver Channel.Heat-clearing and toxic substances removing, antiasthmatic-antitussive, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.The < < SHENGCAO property of medicine is standby wants > >: the circulation of qi promoting of enriching blood, and strong lean kidney, hundred poison can disappear.Calculus Macacae Mulattae: the micro-salty double hardship of nature and flavor, cold flat, nontoxic.Return lung, stomach two warps.Removing phlegm to relieve convulsion, heat-clearing and toxic substances removing.Control expectorant dyspnea of heat type and cough, pediatric epilepsy scared, scrofula sucutaneous nodule.Os pardi: pungent, temperature.Enter liver, kidney channel.Function cures mainly, dispelling wind and removing obstruction in the collateral, strengthening the tendons and bones.Chase after wind analgesic therapy, rheumatic arthralgia, foot knees soreness, spasm of the limbs, numbness, waist knee joint is miserable.Lignum Pini Nodi; Meridian distribution of property and flavor is bitter, and temperature, returns Liver Channel.Effect is dispeiling pathogenic wind and removing dampness, pain relieving.For main anemofrigid-damp arthralgia, severe and migratory arthralgia pain; Foot numbness flaccidity is soft; Traumatic pain.Caulis Trachelospermi: cold nature, bitter in the mouth.Dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence.For rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.< < Jiangxi medical herbs > >: dispelling, collateral-activating, cooling blood for hemostasis.Curing arthritis, pulmonary tuberculosis, spits blood, traumatic hemorrhage, acute toothache, scrofula, venom.Fructus Gleditsiae Abnormalis: pungent salty, temperature, poisonous.Enter lung, stomach, large intestine channel.Function cures mainly: sensible, clearing away phlegm, searches wind.Control apoplexy locked mouth, wind syndrome of head, wind is chronic, sore throat, phlegm dyspnea, feeling of fullness is stagnant, and obstruction and rejection is obstructed, carbuncle, mange, tinea disease.< < property of medicine opinion > >: main broken hard disease, abdominal pain, can have an abortion.Fructus Gleditsia, in wine, is exhausted to its essence, and the one-tenth cream of decocting, is coated with silks, pastes all toxic swellings, the double pain that can relieve the pain.Folium Photiniae (Folium Photiniae serrulatae): meridian distribution of property and flavor: pungent, hardship, flat; Slightly poisonous.Function cures mainly: dispels the wind, and dredging collateral, kidney tonifying.For pathogenic wind-warm arthralgia pain, aching pain in waist and back, the foot and knee being feeble, migraine < < Sheng Nong's herbal classic > >: " support kidney qi, interior impairment of YIN declines, relieving rigidity of muscles and joints fur.”。Scolopendra: salty, pungent, temperature.Poisonous.Return liver, spleen, lung meridian.Relieve internal heat anticancer, relieving spasm by calming endogenous wind, move back inflammation and control skin ulcer.Sanguis Draxonis, sweet salty, flat, enter the heart, Liver Channel, function eliminating stasis to stop pain, hemostasia and promoting granulation, cure mainly ecchymoma due to internal injury, traumatic injury is lost, < < detailed outline > >: " interchannel Liu Shi cloud: Sanguis Draxonis dehematize pain, for the panacea of blood being.Olibanum, Myrrha, though main disorders of blood and doublely enters edema caused by disorder of QI, this specially in blood system person also ".< < Bencao Jingshu > >: " salty master disappears for Sanguis Draxonis, sweet main benefit, the key medicine of dissipating blood stasis blood, tissue regeneration promoting blood." Herba Erodii: nature and flavor are bitter, for pungent, flat.Gui Jing returns liver, kidney, large intestine channel.Function cures mainly dispels rheumatism.For rheumatic arthralgia.< < Traditional Chinese Medicine in Sichuan will > >: expelling wind and cold.Control cough due to lung-heat, the goiter that disappears, is coated with carbuncle pyogenic infections from tumour or sore, helps digestion long-pending glutted.Flos Genkwa: root bark: pungent, bitter, flat.Poisonous.Function cures mainly: subduing swelling and detoxicating, promoting blood circulation and stopping pain.< < property of medicine opinion > >: " main promoting blood circulation, controls malignant boil migratory arthralgia wet, all malicious wind, and extremity contraction is anxious, can not go step, can removing water retention by purgation swelling expire.”。Wintergreen oil: local external use's rubefacient.There is local irritant effect, can promote local blood circulation, external or part are embrocated and can be produced the irritant reaction such as cutaneous vasodilation, the colour of skin be rubescent, and reflexive ground affects skin, muscle, nerve and the joint of corresponding site, play detumescence, antiinflammatory and analgesic activity, also have antipruritic effect.Be used for spraining, contusion, lumbago, myalgia, neuralgia, antipruritic.The all medicine merging of crude drug of the present invention have promoting the flow of QI in the collateral by warming the meridian, and blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, evil-wind expelling and dampness removing, have good therapeutical effect to treatment rheumatalgia, and have no side effect.
Experimental example two, model case
Case 1: Zhao, female is 29 years old, married.There is the little arthralgia of both hands after experiencing cold-damp before half a year in patient, certainly takes after medicinal liquor for rheumatism, and symptom increases the weight of.Like at ordinary times cold.Interphalangeal joint congestion and swelling pain, local pyrexia, obtains cool alleviation of pain, limitation of activity, hands can not be held and take the photograph, stiff 2 hours of morning, feeling thirst but no desire to drink, yellow urine is red.Red tongue, yellow fur is micro-greasy, slippery and rapid pulse.
Western medicine diagnose: rheumatoid arthritis; Tcm diagnosis: arthromyodynia; Dialectical: pyretic toxicity folder is wet, numbness resistance venation.Method for the treatment of: heat-clearing and toxic substances removing, dampness removing a surname numbness, promoting blood circulation to remove obstruction in the collateral.By the invention emplastrum that loses money in a business (according to embodiment 1 method preparation), treat two courses for the treatment of (12 days each courses for the treatment of), arthralgia is clearly better, function of joint is obviously improved, and life course for the treatment of of continual cure can be taken care of oneself completely, substantially recovers on inspection normal.
Case 2: patient week certain, female, 57 years old.Patient main suit's arthralgia is interrupted outbreak 2 years, within nearly 1 year, increases the weight of.Just after cause upper respiratory tract infection, occur heating, joint, whole body distending pain alleviates after western medical treatment, but still the arthralgia that repeatedly shows effect, involve bilateral refer between, the palm refers to, wrist, toes, ankle, knee joint, swelling pain, all night unable to fall asleep, once in outer court, be diagnosed as rheumatoid arthritis.When medical, disease is seen: both hands proximal interphalangeal joint, left side toes joint congestion and swelling pain, and two wrists, double knee joint pain, limitation of activity, can not hold thing, can not squat down, and morning is stiff, difficulty in walking (need to assist in), anemophobia is afraid of cold.Red tongue yellow and thin fur, stringy and thready pulse.Western medicine diagnose: rheumatoid arthritis active stage; Tcm diagnosis: rheumatism involving the bone; Dialectical: wind and cold heat-transformation, with the passing of time impairment of YIN.Method for the treatment of: clearing away heat and nourishing YIN, reducing swelling and alleviating pain, dispelling wind and removing obstruction in the collateral.The application of the invention ointment (according to embodiment 2 methods preparations) after the course for the treatment of (12 days courses for the treatment of) each arthralgia symptom obviously alleviate, can go to sleep peacefully night, aversion to wind is afraid of cold and is alleviated, walking comes to go to a doctor alone.During further consultation, still swelling is obvious in joint, and both hands can not be clenched fist, and tongue arteries and veins is the same.Continue to use two courses for the treatment of, arthralgia is alleviated, and function of joint is obviously improved, can autonomic activities, be completely recovered after using again after treatment 1 course for the treatment of.
Case 3: Zhang, female, 56 years old, teacher.Nineteen ninety-five is diagnosed as rheumatoid arthritis.The little arthralgia swelling of both hands joint stuffiness when medical.It is obvious that play ankylosis morning, movable rear improvement.Finger is fusiformis swelling, and metacarpophalangeal joints is ulnar deviation deformity, and dysfunction can not be adhered to teaching, and life can not be taken care of oneself completely.The application of the invention spray (according to embodiment 3 method preparations) is treated two courses for the treatment of (12 days course for the treatment of), arthralgia is clearly better, function of joint is obviously improved, and two lives course for the treatment of of continual cure can be taken care of oneself completely, substantially recover on inspection normal.
Case 4: summer, female, 48 years old.Patient starts to occur bilateral bilateral articulations digitorum manus symmetry pain the year before, Relapse rate outbreak, time heavy when light, nearly two weeks carrys out aggravation,, the little joint of extremity symmetry red and swollen heat pain when medical, take bilateral articulations digitorum manus and bilateral knee arthralgia as main, joint stuffiness, movable difficulty.Joint obtains cold easypro, and pain can not be touched, and plays ankylosis morning, after activity, take a turn for the better to some extent, and the heat that occurs together, aversion to wind, thirsty.Diagnostics classes rheumatic arthritis (wind heat arthralgia chiefly caused by damp pathogen type).The application of the invention liniment is (according to embodiment 4 method preparations, every day 2 times) treatment, after the course for the treatment of (12 days course for the treatment of), symptom obviously alleviates, and continues to use three courses for the treatment of, just can be freely movable, be completely recovered after using again the after treatment course for the treatment of.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 emplastrum
According to common process, add conventional adjuvant to make emplastrum said medicine, 25g/ pastes, 2 days/paste.
Embodiment 2 ointments
According to common process, add conventional adjuvant to make ointment said medicine, every day 2 times.
Embodiment 3 sprays
Said medicine is added to the agent of conventional adjuvant granulation according to common process.
Embodiment 4 liniments
Lignum Pini Nodi 10kg Caulis Trachelospermi 10kg Fructus Gleditsiae Abnormalis 10kg
Folium Photiniae (Folium Photiniae serrulatae) 10kg Scolopendra 10kg Sanguis Draxonis 10kg
Herba Erodii 10kg
According to common process, add conventional adjuvant to make liniment said medicine.
Embodiment 5 emplastrumes
Lignum Pini Nodi 7kg Caulis Trachelospermi 13kg Fructus Gleditsiae Abnormalis 7kg
Folium Photiniae (Folium Photiniae serrulatae) 13kg Scolopendra 7kg Sanguis Draxonis 13kg
Herba Erodii 7kg
According to common process, add conventional adjuvant to make emplastrum said medicine, 25g/ pastes, 2 days/paste.
Embodiment 6 tinctures
Lignum Pini Nodi 13kg Caulis Trachelospermi 7kg Fructus Gleditsiae Abnormalis 13kg
Folium Photiniae (Folium Photiniae serrulatae) 7kg Scolopendra 13kg Sanguis Draxonis 7kg
Herba Erodii 13kg
According to common process, add conventional adjuvant to make tincture said medicine.
Claims (6)
1. a pharmaceutical composition for the treatment of rheumatalgia, is characterized in that, the crude drug of this pharmaceutical composition consists of:
2. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
4. pharmaceutical composition as claimed in claim 1, is characterized in that, the crude drug of this pharmaceutical composition consists of:
5. the pharmaceutical composition as described in one of claim 1-4, is characterized in that this pharmaceutical composition adds conventional adjuvant to make the emplastrum of clinical acceptance, spray, ointment, liniment or tincture according to common process.
6. the application of the pharmaceutical composition as described in one of claim 1-4 in the medicine of preparation treatment rheumatalgia.
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