CN102872252A - Medicinal composition for treating rheumatic pain - Google Patents
Medicinal composition for treating rheumatic pain Download PDFInfo
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- CN102872252A CN102872252A CN2012104187018A CN201210418701A CN102872252A CN 102872252 A CN102872252 A CN 102872252A CN 2012104187018 A CN2012104187018 A CN 2012104187018A CN 201210418701 A CN201210418701 A CN 201210418701A CN 102872252 A CN102872252 A CN 102872252A
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Abstract
The invention discloses a medicinal composition for treating rheumatic pain. The composition consists of kadsura pepper stem, angelica dahurica, clematis root, Chinese starjasmine stem, asafoetida, siegesbeckia, musk, willow branch, loose knot, bark of Chinese redbud, fructus gleditsiae, ligusticum, mylabris, daphne genkwa and flowering rush butomus. The medicinal composition is prepared into clinically acceptable paste, spray, ointment, liniment or tincture by adding conventional auxiliary materials according to the conventional process. The medicinal composition has the effects of warming and activating meridian, promoting blood circulation to remove blood stasis, relieving swelling and pain and removing wind and damp, has a good treatment effect of treating the rheumatic pain, and does not have toxic or side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of rheumatalgia.
Background technology
Rheumatalgia, its disease belong to paralysis one class, and the traditional Chinese medical science is thought the disease due to wind and the wet two kinds of pathogenic factor combination.Disease opinion has headache, heating, slight perspiration, aversion to wind, heavy sensation of the body, dysuria, joint to ache, can not bend and stretch etc.Arthropathy still with swelling and moving obstacle, is outbreak and alleviates the chronic course of disease alternately except pain is arranged.Because patient's blood circulation is obstructed, cause muscle or organize needed nutrition to carry by blood circulation, cause patient's muscle to lack nutrition and accelerated ageing becomes stiff, serious meeting causes patient's muscle and blood vessel atrophy, some patients were and can occur that disable in the joint and viscera function is depleted.Bi condition is to wait the exopathogen invasion because wind and cold is damp and hot, impatency meridians joint, QI-blood circulation is not smooth, main clinical manifestation be the whole body joint be migration red, swell, weighing, pain.Often refer to rheumatic arthritis.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of rheumatalgia.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The raw material composition of pharmaceutical composition of the present invention is preferably:
The crude drug of pharmaceutical composition of the present invention form can also for:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Pharmaceutical composition of the present invention adds conventional adjuvant according to common process and makes the emplastrum of clinical acceptance, spray, ointment, liniment or tincture.
Pharmaceutical composition of the present invention has promoting the flow of QI in the collateral by warming the meridian, and the effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, evil-wind expelling and dampness removing has good therapeutical effect to the treatment rheumatalgia, and has no side effect.
Following experimental example is used for further specifying the present invention, but is not limited to the present invention.
One, experimental example
1, clinical observation
Emplastrum of the present invention (according to embodiment 1 method preparation) treatment rheumatalgia 100 examples, male's 50 examples wherein, women's 50 examples.
Select the matched group treating rheumatism and strengthening bone to paste, produced by Zhengzhou Hui Zhengtang Pharmaceutical Technology Co., Ltd, treatment rheumatalgia 100 examples, male's 50 examples wherein, women's 50 examples.
2, medicament selection
Treatment group: emplastrum of the present invention (according to the preparation of embodiment 1 method), 30g/ pastes, and one pasted/2 days.
Matched group: rheumatic ostalgia pastes, the medicine company limited production of Yongchun, effluent south, and one pasted/2 days.
3, diagnostic criteria
1. medical history: the invasion and attack history that wind-cold damp pathogen is arranged.
2. symptom: joint or muscular soreness are arranged, numb, pain, even severe pain, movable difficulty is met cold aggravation.
3. sign: the joint of getting involved is because of function limitation due to the pain, but alleviates after the activity, and majority of cases is the pain pneumonedema only, and the minority case is in periarticular mild swelling (without red heat).
4. x ray examination: except the visible soft tissue swelling of minority case, generally without sclerotin change.
5. lab testing: erythrocyte sedimentation rate is most normal, and minority is slightly fast, and it is normal that antistreptolysin 0, rheumatoid factor, routine blood test etc. all belong to.
6. prognosis: deformity is not stayed in the joint of getting involved after catabasis or the healing, and joint function recovery is normal.
4, criterion of therapeutical effect
Draft as follows with reference to " in cure the desease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine 1994 implements:
Clinical recovery: tcm clinical practice symptom, sign disappear or basic the disappearance;
Produce effects: tcm clinical practice symptom, sign obviously change;
Effectively: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all without obviously improving;
5, therapeutic outcome
The Comparison of therapeutic of table 1 treatment rheumatalgia
| Group | The treatment number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate |
| Treatment group | 100 | 65 | 20 | 13 | 2 | 98％ |
| Matched group | 100 | 58 | 13 | 10 | 19 | 81％ |
6, conclusion
Treatment group and matched group stick respectively three courses for the treatment of (12 days each courses for the treatment of), the treatment group invention emplastrum (according to embodiment 1 method preparation) that loses money in a business, and matched group pastes rheumatic ostalgia and pastes.Therapeutic outcome shows, treatment group total effective rate 98% of the present invention, matched group total effective rate 81%.Treatment group of the present invention obviously is better than matched group.
7, discuss
Caulis Piperis Kadsurae in the pharmaceutical composition of the present invention: the dry rattan of Piperaceae plant Radix seu Caulis fici Martinii.Hot, bitter, tepor.Return Liver Channel.Effect is the temperature of dispeling the wind, the meridian dredging.Can treat for anemofrigid-damp arthralgia articular instability, lumbocrural pain, the contracture of muscle arteries and veins.Lung cold is breathed with cough, joint stuffiness." Zhejiang Chinese medicine handbook: a surname's numbness, removing dampness, Tongluo Shujin.Control lower limb knee joint flaccidity syndrome and arthralgia syndrome, arthralgia.The Radix Angelicae Dahuricae: meridian distribution of property and flavor; Suffering, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the wind of the skin migration of dispelling, end the cold pain of the cold stomachache of stomach, whole body cold-damp pain.Radix Clematidis: hot salty, temperature, poisonous.Gui Jing: enter urinary bladder channel.Function: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly: gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Caulis Trachelospermi: be the leaf bine stem of apocynaceae plant trachelospermum jasminoide.Cold nature, bitter in the mouth.Dispelling wind and removing obstruction in the collateral, the removing heat from blood detumescence.Be used for rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down." Jiangxi medical herbs ": dispelling, collateral-activating, cooling blood for hemostasis.Curing arthritis.Resina Ferulae acrid in the mouth, temperature enter liver, spleen, stomach warp.The detumescence of regulating the flow of vital energy is arranged, invigorate blood circulation disappear tired, eliminate the phlegm and the effect of excitor nerve.Herba Siegesbeckiae: meridian distribution of property and flavor: cold, hot, bitter, Liver Channel, kidney channel.Function: wind-damp dispelling, sharp joint, detoxifcation.Cure mainly: be used for that rheumatic arthralgia, muscles and bones are unable, soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema." detailed outline ": " treating the liver the kidney-wind syndrome gas, quadriplegia, a little less than the osteodynia knee joint, all skin ulcers of rheumatism." Moschus is the umbilicus of male Moschus moschiferous and the secretions of the glandular sac between the genitals, is graininess or bulk after the drying.Suffering, temperature, GUIXIN, spleen channel.Function cures mainly: the refreshment of having one's ideas straightened out, and promoting blood circulation to restore menstrual flow, pain relieving is hastened parturition." Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House ": can change the logical pancreas reason of sun.Can thoroughly reach by priming." detailed outline ": logical all keys, open meridians, thoroughly the flesh bone.Ramulus Salicis Babylonicae: hardship, cold.Effect: dispel the wind diuresis, pain relieving, detumescence." must join book on Chinese herbal medicine ": go wind heat, except arthralgia chiefly caused by damp pathogen.Resina Ferulae: the medical material that is a kind of uniqueness in Xinjiang.Perennial once draft as a result.Lignum Pini Nodi: meridian distribution of property and flavor is bitter, and temperature is returned Liver Channel.Effect is dispeiling pathogenic wind and removing dampness, pain relieving.Be used for main anemofrigid-damp arthralgia, the severe and migratory arthralgia pain; Foot numbness flaccidity is soft; Traumatic pain.Cortex cercis chinensis: be the bark of leguminous plant cercis.Warm in nature, acrid in the mouth is bitter, and is poisonous.Enter liver, spleen two warps.Function cures mainly: promoting blood circulation to restore menstrual flow, subduing swelling and detoxicating.Control anemofrigid-damp arthralgia, women's amenorrhea, vim and vigour pain, sore throat drenches disease, carbuncle." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control bones and muscles pain, anemofrigid-damp arthralgia, apathy, the paralysis flaccidity is soft, and warm muscle ends lumbago, controls married woman's cold in blood stomachache." " detailed outline ": " blood-activating and qi-promoting, subduing swelling and detoxicating." Fructus Gleditsiae Abnormalis: hot salty, temperature, poisonous.Enter lung, stomach, large intestine channel.Function cures mainly: sensible, clearing away phlegm is searched wind.Control the apoplexy locked mouth, wind syndrome of head, wind is chronic, sore throat, phlegm dyspnea, feeling of fullness is stagnant, and obstruction and rejection is obstructed, carbuncle, mange, tinea disease." property of medicine opinion ": main broken hard disease, abdominal pain can be had an abortion.Fructus Gleditsia in wine, is exhausted its essence, and the one-tenth cream of frying in shallow oil is coated with silks, pastes all toxic swellings, the double pain that can relieve the pain.Rhizoma Ligustici: the dry rhizome of samphire Rhizoma Ligustici or Rhizoma Ligustici and root.Suffering, temperature.Return urinary bladder channel.Function cures mainly: dispel the wind cold expelling, dehumidifying, pain relieving.Be used for anemofrigid cold, top, mountain peak pain, rheumatism podomere arthralgia pain." book on Chinese herbal medicine just ": " treat rheumatism and have loose bowels, the acute infantile convulsion mist reveals the miasma epidemic disease." " book on Chinese herbal medicine is new again ": " dispelling the wind and dampness pathogens sufferings, the wind syndrome of head order is swollen, the malaria of having loose bowels dysentery." Mylabris: acrid in the mouth; Warm in nature; Large poison.Enter large intestine, small intestinal, liver, kidney channel.Function cures mainly: the counteracting toxic substances phagedenoma; The removing blood stasis eliminating stagnation.Main carbuncle; Scrofula; Stubborn dermatitis; Amenorrhea; Lump in the abdomen; Cancerous protuberance." property of medicine opinion ": control scrofula, the tonneau water channel.Moschus: Flos Genkwa: root bark: hot, bitter, flat.Poisonous.Function cures mainly: subduing swelling and detoxicating, promoting blood circulation and stopping pain." property of medicine opinion ": " main promoting blood circulation, it is wet to control the malignant boil migratory arthralgia, all malicious wind, the extremity contraction is anxious, can not go the step, can removing water retention by purgation swelling expire.”。CAOXIE: property is flat, bitter in the mouth.Enter Liver Channel, stomach warp, urinary bladder channel.Function: dampness removing goes turbid, and blood stasis dispelling dispels the wind.Dampness removing goes turbid, wind expelling stagnation removing." herbal classic ": main lumbago and backache, the bone strengthening joint, wind and cold wetted perimeter numbness, malignant boil is recover not, steam.The all medicine merging of crude drug of the present invention have promoting the flow of QI in the collateral by warming the meridian, and blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, evil-wind expelling and dampness removing have good therapeutical effect to the treatment rheumatalgia, and have no side effect.
Experimental example two, model case
Case 1: Wang, woman, 11 years old.Patient usually body constitution is relatively poor, is easy to flu, and bilateral occurs after suffering from cold before 2 months and refer to that the joint symmetry swells and ache between (toe), companion's deadlock in morning more than 2 hours, aversion to cold and preference for warmth, weak.Body of the tongue is light red partially dark, white and thin fur, and deep-thready pulse is string slightly.Western medicine diagnose: juvenile rheumatoid arthritis.Tcm diagnosis: rheumatoid arthritis, the cold card of containing of suffering from a deficiency of the kidney.Dialectical: wind and cold heat-transformation, with the passing of time impairment of YIN.Method for the treatment of: the kidney invigorating cold expelling, expelling wind and removing dampness.By the invention emplastrum that loses money in a business (according to the preparation of embodiment 1 method), one pasted/2 days.Treat three courses for the treatment of (12 days per courses for the treatment of), each arthralgia symptom obviously alleviates, and morning, deadlock was less than half an hour, and the state of an illness is clearly better.The tongue arteries and veins is the same during further consultation.Three courses for the treatment of of continuous docile and obedient invention plaster, arthralgia is alleviated, and function of joint is obviously improved.Cure fully after continuing to strengthen two courses for the treatment of.
Case 2: high certain, woman, 60 years old.The main suit is multi-joint pain 30 years repeatedly, increased the weight of 1 month.The patient double knee joint and heel pain occurred without obvious inducement before 30 years, without swelling, examined in the outer court and to be RA, gave the analgesic treatment, and symptom is shown effect repeatedly, aggravation before 1 month.Inscribe: left hand the 2nd, 3 nearly articulations digitorum manus swell and ache, two wrists, both shoulders pain, and double knee joint swells and ache.Xerostomia, without oral ulcer and erythra, without Raynaud phenomenon, conscious aversion to cold and cold limbs, aversion to wind, poor appetite, dormancy can, two just be transferred.Have a medical check-up: left hand the 2nd, 3 proximal interphalangeal joint swelling, tenderness are obvious, local Pi Wengao, and left elbow flexing is limited, and two knee joints stretch difficulty, attach most importance to the right side.The dark yellow fur of tongue, slippery and rapid pulse.Western medicine diagnose: rheumatoid arthritis.Tcm diagnosis: arthromyodynia, it is damp and hot that card belongs to the deficiency of vital energy, obstruction of collaterals by blood stasis.Method for the treatment of: functions dispelling wind and clearing away cold, removing dampness, dissipating phlegm and eliminating blood stasis.The application of the invention ointment (according to embodiment 2 methods preparations) treatment four courses for the treatment of (12 days each courses for the treatment of), the patient is conscious, and the whole body arthralgia is clearly better, and receives the food amelioration, the peace of sleeping, and hands can write, can walking freely.Continue to use two courses for the treatment of of ointment of the present invention, patient's pain disappears substantially, and swelling disappears entirely, and activity freely.Cure fully after continuing to strengthen three courses for the treatment of.
Case 3: the Wang, the woman is 35 years old, married.The patient the little arthralgia of both hands occurs after experiencing cold-damp before half a year, certainly take medicinal liquor for rheumatism after, sx↑.Like at ordinary times cold.The interphalangeal joint congestion and swelling pain, local pyrexia gets cool then alleviation of pain, limitation of activity, hands can not be held and take the photograph, stiff 3 hours of morning, feeling thirst but no desire to drink, yellow urine is red.Red tongue, yellow fur is little greasy, slippery and rapid pulse.Western medicine diagnose: rheumatoid arthritis; Tcm diagnosis: arthromyodynia; Dialectical: the pyretic toxicity folder is wet, numbness resistance venation.Method for the treatment of: heat-clearing and toxic substances removing, dampness removing a surname numbness, promoting blood circulation to remove obstruction in the collateral.The application of the invention spray (according to the preparation of embodiment 3 methods) is treated two courses for the treatment of (12 days each courses for the treatment of), arthralgia is clearly better, function of joint is obviously improved, and life course for the treatment of of continual cure can be taken care of oneself fully, substantially recovers on inspection normal.
Case 4: Lee, man, 55 years old.Patient main suit's arthralgia is interrupted outbreak 2 years, increases the weight of in nearly 1 year.Just heating occurs after the cause upper respiratory tract infection, joint, whole body distending pain alleviates behind western medical treatment, but still the arthralgia that repeatedly shows effect, involve bilateral refer between, the palm refers to, wrist, toes, ankle, knee joint, swelling pain, all night unable to fall asleep, once be diagnosed as rheumatoid arthritis in the outer court.Disease is seen when medical: both hands proximal interphalangeal joint, left side toes joint congestion and swelling pain, and two wrists, double knee joint pain, limitation of activity can not be held thing, can not squat down, and morning is stiff, difficulty in walking (need to assist in), anemophobia is afraid of cold.The red tongue yellow and thin fur, stringy and thready pulse.Western medicine diagnose: rheumatoid arthritis active stage; Tcm diagnosis: rheumatism involving the bone; Dialectical: wind and cold heat-transformation, with the passing of time impairment of YIN.Method for the treatment of: clearing away heat and nourishing YIN, reducing swelling and alleviating pain, dispelling wind and removing obstruction in the collateral.The application of the invention emplastrum (according to embodiment 4 methods preparations) after course for the treatment of (12 days courses for the treatment of) each arthralgia symptom obviously alleviate, can go to sleep peacefully night, aversion to wind is afraid of cold and is alleviated, walking comes to go to a doctor alone.Still swelling is obvious in the joint during further consultation, and both hands can not be clenched fist, and the tongue arteries and veins is the same.Continue to use two courses for the treatment of, arthralgia is alleviated, and function of joint is obviously improved, can autonomic activities, be completely recovered after using again after treatment 1 course for the treatment of.
Case 5: Zhang, woman, 50 years old, workman.Nineteen ninety-five is diagnosed as rheumatoid arthritis.The little arthralgia swelling of both hands joint stuffiness when medical.It is obvious that play ankylosis morning, movable rear the improvement.Finger is fusiformis swelling, and metacarpophalangeal joints is the ulnar deviation deformity, and dysfunction can not be adhered to teaching, and life can not be taken care of oneself fully.The application of the invention ointment (according to the preparation of embodiment 5 methods) is treated two courses for the treatment of (12 days course for the treatment of), arthralgia is clearly better, function of joint is obviously improved, and two lives course for the treatment of of continual cure can be taken care of oneself fully, substantially recover on inspection normal.
Case 6: the week certain, woman, 45 years old.The patient begins to occur bilateral bilateral articulations digitorum manus symmetry pain the year before, Relapse rate outbreak, the time heavy when light, nearly two weeks comes aggravation, and the little joint of extremity symmetry red and swollen heat pain when medical is take bilateral articulations digitorum manus and bilateral knee arthralgia as main, joint stuffiness, movable difficulty.The joint gets cold then easypro, and pain can not be touched, and plays ankylosis morning, take a turn for the better to some extent after the activity, and the heat that occurs together, aversion to wind, thirsty.Diagnostics classes rheumatic arthritis (wind heat arthralgia chiefly caused by damp pathogen type).The application of the invention liniment (prepares according to embodiment 6 methods, every day 2 times) treatment, symptom obviously alleviates after the course for the treatment of (12 days course for the treatment of), continues to use three courses for the treatment of, just can be freely movable, be completely recovered after using again the after treatment course for the treatment of.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 emplastrum
Said medicine is added conventional adjuvant according to common process make emplastrum, 30g/ pastes, 2 days/paste.
Embodiment 2 ointments
Said medicine is added conventional adjuvant according to common process make ointment, every day 2 times.
Embodiment 3 sprays
Said medicine is added conventional adjuvant according to common process make spray.
Embodiment 4 emplastrumes
Said medicine is added conventional adjuvant according to common process make emplastrum.
Embodiment 5 ointments
Said medicine is added conventional adjuvant according to common process make emplastrum, 30g/ pastes, 2 days/paste.
Embodiment 6 liniments
Said medicine is added conventional adjuvant according to common process make liniment.
Embodiment 7 tinctures
Said medicine is added conventional adjuvant according to common process make tincture.
Claims (10)
1. a pharmaceutical composition for the treatment of rheumatalgia is characterized in that, the crude drug of said composition consists of:
2. pharmaceutical composition as claimed in claim 1 is characterized in that, the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1 is characterized in that, the crude drug of this pharmaceutical composition consists of:
4. pharmaceutical composition as claimed in claim 3 is characterized in that, the crude drug of this pharmaceutical composition consists of:
5. such as the described pharmaceutical composition of one of claim 1-4, it is characterized in that the crude drug of this pharmaceutical composition consists of:
6. pharmaceutical composition as claimed in claim 5 is characterized in that, the crude drug of this pharmaceutical composition consists of:
7. pharmaceutical composition as claimed in claim 5 is characterized in that, the crude drug of this pharmaceutical composition consists of:
8. pharmaceutical composition as claimed in claim 5 is characterized in that, the crude drug of this pharmaceutical composition consists of:
9. such as the described pharmaceutical composition of one of claim 1-8, it is characterized in that this pharmaceutical composition adds conventional adjuvant according to common process and makes the emplastrum of clinical acceptance, spray, ointment, liniment or tincture.
10. such as the application of the described pharmaceutical composition of one of claim 1-8 in the medicine of preparation treatment rheumatalgia.
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| CN201210418701.8A CN102872252B (en) | 2012-10-29 | 2012-10-29 | Medicinal composition for treating rheumatic pain |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550471A (en) * | 2013-10-25 | 2014-02-05 | 王增智 | Traditional Chinese medicine (TCM) composition for treating Bi pain |
| CN105435109A (en) * | 2015-12-18 | 2016-03-30 | 贯士峰 | Rheumatalgia treating traditional Chinese medicine composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190014A (en) * | 1998-02-17 | 1998-08-12 | 刘煌清 | Medicine for hemiplegia |
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2012
- 2012-10-29 CN CN201210418701.8A patent/CN102872252B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190014A (en) * | 1998-02-17 | 1998-08-12 | 刘煌清 | Medicine for hemiplegia |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550471A (en) * | 2013-10-25 | 2014-02-05 | 王增智 | Traditional Chinese medicine (TCM) composition for treating Bi pain |
| CN105435109A (en) * | 2015-12-18 | 2016-03-30 | 贯士峰 | Rheumatalgia treating traditional Chinese medicine composition |
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| CN102872252B (en) | 2014-07-16 |
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Granted publication date: 20140716 Termination date: 20181029 |