CN107837375A

CN107837375A - A kind of saussurea involucrata Wind-dispelling ointment and preparation method thereof

Info

Publication number: CN107837375A
Application number: CN201711130823.6A
Authority: CN
Inventors: 徐建业
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-11-15
Filing date: 2017-11-15
Publication date: 2018-03-27

Abstract

The invention discloses a kind of saussurea involucrata Wind-dispelling ointment and preparation method thereof, the bulk drug is 80 100 parts of lanatechead saussurea herb with flower, the hedgehog heart 80 100,60 80 parts of Roots of Peanut, 50 70 parts of the Fen , Common St.Paulswort Herbs of pepper bar 60 80,50 70 parts of barrenwort, 40 60 parts of lycopodium calvatum, 40 60 parts of eggplant root, 30 60 parts of snakeskin, 30 60 parts of spiceleaf, 20 40 parts of cicada slough, 20 30 parts of garlic, 20 30 parts of mulberry leaf, 20 30 parts of safflower, 38 parts of 20 30 parts of sealwort, 10 20 parts of withy, 38 parts of ginger and radix glycyrrhizae.According to the compatibility mechanism of science in we, monarch is acted in concert with each other, and for the purpose of dispelling wind and eliminating dampness, using cardiac stimulant dredging collateral, temperature male wind-supplying kidney as direction, obtains preferable therapeutic effect.

Description

A kind of saussurea involucrata Wind-dispelling ointment and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, more particularly, to a kind of saussurea involucrata Wind-dispelling ointment and preparation method thereof.

Background technology

Rheumatic arthritis is a kind of common acute or chronic connective tissue inflammation.Rheumatic arthritis broadly should Including rheumatoid arthritis, recurrent exerbation and heart can be involved.Clinic is with the migrans miserable, heavily write in joint and muscle, pain It is characterized, belongs to allergic disease, be one of main performance of rheumatic fever, more with febris acuta and arthralgia onset.Wind Wet arthritis are performance of the rheumatic fever in joint, and its classical symptom is migrans, multiple large joint inflammation, common by a pass Section is transferred to another joint, and red, swollen, scorching hot, severe pain is locally presented in lesion, and some patients also have several joints while fallen ill. Rheumatoid arthritis is a kind of systemic autoimmune disease of chronic refractory based on arthropathy.Modern medicine Research thinks that various tissues such as synovial membrane, cartilage, ligament, the tendon for forming joint have lesion with the bone being connected, but most basic Lesion occur in synovial membrane.According to its clinical manifestation, the category of the category traditional Chinese medical science/rheumatism.Therefore recognize herein according to the morbidity theory of the traditional Chinese medical science It is that this sick internal factor occurs for physically weak sense heresy, wind-cold damp pathogen is that this sick external factor occurs, and obstruction of meridians and collaterals is that this occurs The main pathogenesis of disease.Based on non-steroid anti-inflammatory drug, acute inflammation typically disappeared doctor trained in Western medicine in 2~4 weeks, did not stayed sequelae, but Normal recurrent exerbation.

The traditional Chinese medical science has the safe efficient advantage not recurred in terms of rheumatic arthritis is treated, and can treat both principal and secondary aspect of disease, by The popular welcome of rheumatisant.The Chinese patent of Application No. 200910070618.4 discloses one kind and treats arthralgia, The traditional Chinese medicine for outer use of the disease such as aching pain in shoulder and back, rheumatoid redness, more particularly to one kind is with Chinese herbal medicine paprika, rhizoma zingiberis, the root of Dahurain angelica, horse There is wind-dispelling relaxing muscles and tendons, the rubber ointment of promoting blood circulation and stopping pain effect made of Qian Ziwei raw materials.The flavour of a drug of the invention are simple, and curative effect shows Write, disclose in specification obtained on the clinical treatment for the treatment of various diseases more than 98% effective percentage.Application No. 201510042211.6 Chinese patent discloses a kind of Chinese medicine for treating rheumatoid arthritis, and it is by following traditional Chinese medicines material system Standby obtained medicinal liquor：Deer horn, the bark of eucommia, cortex acanthopanacis, safflower, levisticum, rhizoma atractylodis, Ligusticum wallichii, teasel root, eggplant root, the root of bidentate achyranthes, mulberry fruit, radix glycyrrhizae. The Chinese medicine of the invention clinical tests prove that, Chinese medicine of the invention synergy is strong, has to rheumatoid arthritis good Therapeutic effect, its preparation method is simple and easy, and dosage is few, has no toxic side effect, is adapted to promote the use of.But the two formulas are controlled Therapeutic effect is still not ideal enough.

The content of the invention

In view of this, the purpose of the present invention is in view of the shortcomings of the prior art, there is provided a kind of saussurea involucrata Wind-dispelling ointment and its preparation Method, solve the problems, such as that existing Chinese medicine wind-dispelling effect is undesirable.

To reach above-mentioned purpose, the present invention uses following technical scheme：

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are lanatechead saussurea herb with flower 80-100 parts, hedgehog heart 80-100, Roots of Peanut 60-80 Part, pepper bar 60-80 Fen , Common St.Paulswort Herb 50-70 parts, barrenwort 50-70 parts, lycopodium calvatum 40-60 parts, eggplant root 40-60 parts, snakeskin 30-60 parts, spiceleaf 30-60 parts, cicada slough 20-40 parts, garlic 20-30 parts, mulberry leaf 20-30 parts, safflower 20-30 parts, sealwort 20- 30 parts, withy 10-20 parts, ginger 3-8 parts and radix glycyrrhizae 3-8 parts.

Further, the bulk drug is lanatechead saussurea herb with flower 85-95 parts, hedgehog heart 85-95, Roots of Peanut 65-75 parts, pepper bar 65-75 Fen , Common St.Paulswort Herb 55-65 parts, barrenwort 55-65 parts, lycopodium calvatum 45-55 parts, eggplant root 45-55 parts, snakeskin 40-50 parts are fragrant Leaf 40-50 parts, cicada slough 25-35 parts, garlic 22-28 parts, mulberry leaf 22-28 parts, safflower 22-28 parts, sealwort 22-28 parts, withy 12-18 parts, ginger 4-6 parts and radix glycyrrhizae 4-6 parts.

Further, the bulk drug is 90 parts of lanatechead saussurea herb with flower, the hedgehog heart 90,70 parts of Roots of Peanut, the Fen , pig Xian of pepper bar 70 60 parts of grass, 60 parts of barrenwort, 50 parts of lycopodium calvatum, 50 parts of eggplant root, 45 parts of snakeskin, 45 parts of spiceleaf, 30 parts of cicada slough, 25 parts of garlic, mulberry 6 parts of 25 parts of leaf, 25 parts of safflower, 25 parts of sealwort, 15 parts of withy, 5 parts of ginger and radix glycyrrhizae.

The preparation method of the Wind-dispelling ointment, comprises the following steps：

Step 1: collect winter snows dress is embedded in underground in a reservoir, Second Year spring takes out the snow-broth that snow melt obtains, standby With；

Step 2: pepper bar is cleaned, is cut into 2-3 centimetres of segment, 50-60 minutes are soaked in snow-broth obtained by step 1, Boiled in iron pan, slow fire decocts 30-50 minutes, takes cooking liquor standby；

Step 3: the hedgehog heart, snakeskin, spiceleaf, cicada slough, baking and banking up with earth, being ground into fine powder, add the mixed stirring of honey, obtain mixed Close honey slurry；The weight ratio of the honey and fine powder is 1-2:1；

Step 4: by Roots of Peanut, eggplant root, mulberry leaf co-grinding, it is added in cooking liquor obtained by step 2, with equivalent ethanol Mixing, flow back 20-30 minute effective component extractings, collects phegma, is condensed into paste；

Step 5: garlic is wrapped up with clay, calcination in convulsive seizure due to phlegm-fire is placed in, to burned taste is smelt, divests clay, is taken out burnt Garlic, it is ground into fine powder；

Step 6: lanatechead saussurea herb with flower, Common St.Paulswort Herbs, barrenwort, lycopodium calvatum, safflower, sealwort, withy, ginger and radix glycyrrhizae, through powder It is broken, ultramicro grinding, obtain the ultra-micro powder that particle diameter is 8-10 μm；

Step 7, by ultra-micro powder, step 5 gained garlic coke powder, step 4 gained paste obtained by step and step 6 And blending honey slurry is well mixed；Obtain the Chinese medicinal ingredients of Wind-dispelling ointment；

Step 8: adding auxiliary material into effective component of chinese medicine obtained by step 7, Wind-dispelling ointment is produced to obtain；The auxiliary material and Chinese medicine The weight ratio of active ingredient is 1-1.2：1.

Further, the honey is one or more kinds of mixtures in sophorae honey, Mel or cercis nectar.

Further, the auxiliary material is, sesame oil, glycerine, the mixture of lauryl sodium sulfate and azone；Its weight Than for 5-6:0.5-1:0.1-0.2:0.05.

Lanatechead saussurea herb with flower

Meridian distribution of property and flavor：It is warm-natured, sweet, mildly bitter flavor；Enter Liver Channel, kidney channel.

Effect：Invigorating kidney yang, menstruation regulating blood, strengthening the bones and muscles, wind-damp dispelling.

Cure mainly：Impotence essence is cold, soreness and weakness of waist and knees, irregular menstruation, under uterine bleeding band, viscerasthenia hemoptysis, and arthralgia pain due to rheumatism.The hedgehog heart, contains There are norepinephrine, adrenaline, and 4- (2- amino-ethyls)-pyrocatechol, catecholamine etc. can be cardioactive interior Secretory material.

Roots of Peanut, rich in white reed lamb's-quarters alcohol.RV have eliminating evil without hinder just, qi-restoratives without help heresy double effects, Also the toxic side effect of Radiotherapy chemotherapy, while also prevention of cardiovascular disease effect can substantially be mitigated.

Withy

Meridian distribution of property and flavor：Property it is bitter, taste is trembled with fear；Enter the positive bright, JUE YIN meridian of foot.

Major function：Wind-dispelling, diuresis, relieve pain, detumescence.Control arthralgia pain due to rheumatism, gonorrhoea, gonorrhoea, urinary obstruction, infectiousness liver Inflammation, wind swell, furunculosis, erysipelas, dental caries, and gum swells.

Safflower

Meridian distribution of property and flavor：It is mild-natured, sweet；The thoughts of returning home, Liver Channel.

Major function：It is promoting blood circulation and removing blood stasis to stimulate the menstrual flow, removing pattogenic heat from the blood and toxic material from the body.For：Amenorrhea lump in the abdomen lump in the abdomen, postpartum stasis, febrile virulent maculae, melancholy ruffian Vexed, palpitation with fear is gone mad.

Sealwort

Meridian distribution of property and flavor：It is mild-natured, sweet, returns spleen, lung, kidney channel；

Effect：Effect boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing；Cure mainly and be used for weakness of the spleen and the stomach, fatigue and asthenia, dry food It is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, Heat Diabetes.

Common St.Paulswort Herb

Meridian distribution of property and flavor, bitter are cold in nature.Return liver and kidney channel.

Effect：Zhong Yao Common St.Paulswort Herbs have a wind-damp dispelling, and degrading the channel is clearing heat and detoxicating.

Cure mainly：For arthralgia pain due to rheumatism, numb limb, carbuncle sore tumefacting virus, eczema itch.

Barrenwort

Meridian distribution of property and flavor：It is acrid flavour, sweet, it is warm-natured；Return liver and kidney channel.

Effect：Herba Epimedii has tonifying kidney and strengthening yang, dispelling wind and eliminating dampness.

Cure mainly：Ache for impotence due to deficiency of the kidney, waist-leg weakness, wind-cold-dampness arthralgia, muscles and bones.

Snakeskin

Meridian distribution of property and flavor：Taste is salty, sweet, mild-natured.Return liver warp.

Effect：Wind-dispelling, arresting convulsion, moves back screen, detoxifies.

Cure mainly：For child convulsion, spasm of twitching, ocular, larynx numbness, swollen, pruitus is treated.

Cicada slough

Meridian distribution of property and flavor, it is sweet, salty, it is cool in nature.Return lung, Liver Channel.

Effect, dispelling wind and heat from the body, relieving sore-throat open sound, promoting eruption, removing nebula, Inflammation Zhijing.

Cure mainly, for anemopyretic cold, warm disease is from the beginning of pharyngalgia sound is mute, measles without adequate eruption, rubella itch, cataract, anxious slow frightened Wind, lockjaw card, nocturnal fretfulness in infants are uneasy.

Spiceleaf

Meridian distribution of property and flavor, it is pungent, warm.Return stomach, Liver Channel.

Major function, promoting the circulation of qi middle benefit gas.Main gastral cavity pain, indigestion, arthralgia pain due to rheumatism, hernia, eczema of scrotum, mange.

Garlic

Meridian distribution of property and flavor：It is pungent, temperature.Returns spleen, stomach, lung channel.

Effect：Removing toxic substances, detumescence, desinsection.

Garlic cures mainly：For carbuncle swells furuncle, tinea sore, tuberculosis, pertussis, dysentery, diarrhea, abdominal pain due to enterositosis.

Pepper bar, there is eliminating cold-damp, by cold numbness, scattered blood stasis stagnates.Control rheumatism crymodynia, the effect of pernio.

Mulberry leaf

Meridian distribution of property and flavor：It is bitter, sweet, tremble with fear.Return lung, Liver Channel.

Effect：Dispelling wind and heat from the body, clear liver and improve vision.

Cure mainly：For syndrome of superficies attacked by wind-heat, warm disease is from the beginning of, cough caused by dryness-heat, red eye, swell pain, and mesh is dark dim-sighted etc..

Lycopodium calvatum

Meridian distribution of property and flavor：It is mildly bitter flavor, pungent, it is warm-natured；Return liver, spleen, kidney channel.

Effect：Can heat-clearing, hemostasis, myogenic, dampness removing, analgesic, dredging collateral, expelling wind and clearing away cold, dehumidification swelling, relaxing tendons and activating collaterals.

Cure mainly：For wind-cold-dampness arthralgia, joint pain, spit blood, bleeding from five sense organs or subcutaneous tissue, have blood in stool, numbness of skin, tetraparesis, oedema, bruise The diseases such as damage.

Eggplant root

Meridian distribution of property and flavor：It is sweet, pungent, it is cold in nature.Returns spleen, stomach, intestine and small intestine warp.

Effect, expelling wind and removing dampness, clearing away heat to stop bleeding.

Cure mainly, for beriberoid pyretic arthralgia, tinea pedis, bloody flux, have blood in stool, hemorrhoid blood, blood strangury, women's pruritus vulvae, pruitus, pernio.

Ginger

Meridian distribution of property and flavor：Slightly warm in nature, acrid flavour；Return lung warp, the spleen channel, stomach.

Effect：Inducing diaphoresis cough-relieving, warming lung and reducing phlegm, removing toxic substances, wind dispelling cold dispelling.

Cure mainly：Vomiting, turgor, anemofrigid cold, cough ant phlegm, diarrhea.

Radix glycyrrhizae

Meridian distribution of property and flavor：Nature and flavor, it is sweet, it is mild-natured；The thoughts of returning home, lung, spleen, stomach.

Effect, invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.

Cure mainly, for weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle swells sore Poison, alleviate drug toxicity, strong.

The beneficial effects of the invention are as follows：

The present invention menstruation regulating blood, strengthening the bones and muscles, the lanatechead saussurea herb with flower of wind-damp dispelling, contains norepinephrine, adrenal gland with invigorating kidney yang Element, and 4- (2- amino-ethyls)-pyrocatechol, catecholamine etc. are understood the hedgehog heart of cardioactive incretion material, dispelled Rheumatism, degrading the channel and have a tonifying kidney and strengthening yang at clearing heat and detoxicating Common St.Paulswort Herbs, and the barrenwort of dispelling wind and eliminating dampness effect is monarch drug in a prescription；RV With eliminating evil without hinder just, double effects of the qi-restoratives without helping heresy, also can substantially mitigate the toxic side effect of Radiotherapy chemotherapy, also simultaneously Have prevention of cardiovascular disease effect, rich in white reed lamb's-quarters alcohol Roots of Peanut and to there is eliminating cold-damp, by cold numbness, scattered blood stasis stagnate act on it is peppery Green pepper bar, with analgesic, dredging collateral, expelling wind and clearing away cold, dehumidification swelling, relaxing tendons and activating collaterals lycopodium calvatum, the eggplant root of expelling wind and removing dampness, wind-dispelling is fixed Shy, the snakeskin of removing toxic substances, control the spiceleaf of arthralgia pain due to rheumatism, boosting qi and nourishing yin, invigorating the spleen, moistening lung, the sealwort of kidney-nourishing and the cicada slough of Inflammation Zhijing For ministerial drug, with removing toxic substances, detumescence, the garlic of desinsection, dispelling wind and heat from the body, clear liver and improve vision mulberry leaf, the safflower promoting blood circulation and removing blood stasis to stimulate the menstrual flow and dispels Wind, diuresis, analgesic, the withy of detumescence be adjutant, and inducing diaphoresis cough-relieving is warming lung and reducing phlegm, removing toxic substances, wind dispelling cold dispelling ginger with invigorate the spleen and benefit qi, Clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, the radix glycyrrhizae of coordinating the drug actions of a prescription is to make medicine.

According to the compatibility mechanism of science in we, monarch is acted in concert with each other, and for the purpose of dispelling wind and eliminating dampness, is led to cardiac stimulant Network, temperature male wind-supplying kidney are direction, obtain preferable therapeutic effect.The monarch drug in a prescription hedgehog heart contains norepinephrine, adrenal gland in side Element, and the cardioactive incretion material of the meeting such as 4- (2- amino-ethyls)-pyrocatechol, catecholamine, can coordinate the heart Dirty function, the recovery of cardiac stimulus function, heart are the total activation rooms of blood, and cardiac stimulant is then beneficial to dredging collateral, lanatechead saussurea herb with flower, Common St.Paulswort Herbs and The effect of barrenwort is respectively provided with invigorating kidney yang wind-damp dispelling, heart kidney two is dirty, interacts, conditions each other, and is to maintain physiological function The basis of relative equilibrium, under physiological status, heart-yang constantly declines, kidney yin constantly rises, intersecting up and down, coordination of YIN and YANG, is referred to as " coordination between the heart and kidney ".Pepper bar has eliminating cold-damp in ministerial drug, and by cold numbness, the sluggish effect of scattered blood stasis, lycopodium calvatum, which have, to relieve pain, dredging collateral, Expelling wind and clearing away cold, dehumidification swelling, the effect of relaxing tendons and activating collaterals；Spiceleaf cures mainly arthralgia pain due to rheumatism, eggplant root then main expelling wind and removing dampness, snakeskin wind-dispelling, The effect calmed the frightened with removing toxic substances, sealwort have a boosting qi and nourishing yin, invigorating the spleen, moistening lung, the effect of kidney-nourishing, and cicada slough has Inflammation Zhijing Effect is ministerial drug, seven medicines share can wind-dispelling, dehumidifying, cold dispelling, analgesic, dredging collateral, yin-nourishing, invigorating the spleen, moistening lung, kidney-nourishing, aid in monarch drug in a prescription Function, the deficiency of gain monarch drug in a prescription effect.With removing toxic substances, detumescence, the Tibetan of the garlic of desinsection, the mulberry leaf of dispelling wind and heat from the body and promoting blood circulation to remove blood stasis The withy of safflower and wind-expelling pain-stopping is adjutant, the deficiency of gain the monarch and his subjects' drug effect, and the effect of raising dispelling wind and eliminating dampness is with inducing diaphoresis cough-relieving, warm lung Resolving sputum, removing toxic substances, wind dispelling cold dispelling ginger and invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, and the radix glycyrrhizae of coordinating the drug actions of a prescription is Make medicine.All medicines share, it can play a part of recovering grain function, wind-damp dispelling.

Ointment is extracted, according to its significant effect of clinical experience better than the light water side of entering with next year snow water as medicine Effect, digesting between each medicine can be more efficiently promoting with the preparation extraction process of capsicum water through each bulk drug, Coordinative role.The effect of further promoting traditional Chinese medicinal ointment of the present invention.

Embodiment

Embodiment 1

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are 80 parts of lanatechead saussurea herb with flower, the hedgehog heart 80,60 parts of Roots of Peanut, pepper bar 60 50 parts of Fen , Common St.Paulswort Herbs, 50 parts of barrenwort, 40 parts of lycopodium calvatum, 40 parts of eggplant root, 30 parts of snakeskin, 30 parts of spiceleaf, 20 parts of cicada slough, garlic 20 parts, 20 parts of mulberry leaf, 20 parts of safflower, 20 parts of sealwort, 10 parts of withy, 3 parts of 3 parts of ginger and radix glycyrrhizae.

Its preparation method, comprise the following steps：

Step 2: pepper bar is cleaned, is cut into 2 centimetres of segments, soaked 50 minutes in snow-broth obtained by step 1, in iron pan In boil, slow fire decocts 30 minutes, takes cooking liquor standby；

Step 3: the hedgehog heart, snakeskin, spiceleaf, cicada slough, baking and banking up with earth, being ground into fine powder, add the mixed stirring of sophorae honey, obtain Blending honey is starched；The weight ratio of the sophorae honey and fine powder is 1:1；

Step 4: by Roots of Peanut, eggplant root, mulberry leaf co-grinding, it is added in cooking liquor obtained by step 2, with equivalent ethanol Mixing, flow back 20 minutes effective component extractings, collects phegma, is condensed into paste；

Step 6: lanatechead saussurea herb with flower, Common St.Paulswort Herbs, barrenwort, lycopodium calvatum, safflower, sealwort, withy, ginger and radix glycyrrhizae, through powder It is broken, ultramicro grinding, obtain the ultra-micro powder that particle diameter is 8 μm；

Step 8: adding auxiliary material into effective component of chinese medicine obtained by step 7, Wind-dispelling ointment is produced to obtain；The auxiliary material and Chinese medicine The weight ratio of active ingredient is 1：1. the auxiliary material is, sesame oil, glycerine, the mixture of lauryl sodium sulfate and azone； Its weight ratio is 5:0.5:0.1:0.05.

Embodiment 2

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are 100 parts of lanatechead saussurea herb with flower, the hedgehog heart 100,80 parts of Roots of Peanut, pepper bar 80 70 parts of Fen , Common St.Paulswort Herbs, 70 parts of barrenwort, 60 parts of lycopodium calvatum, 60 parts of eggplant root, 60 parts of snakeskin, 60 parts of spiceleaf, 40 parts of cicada slough, garlic 30 parts, 30 parts of mulberry leaf, 30 parts of safflower, 30 parts of sealwort, 20 parts of withy, 8 parts of 8 parts of ginger and radix glycyrrhizae.

Its preparation method, comprise the following steps：

Step 2: pepper bar is cleaned, is cut into 3 centimetres of segments, 50-60 minutes are soaked in snow-broth obtained by step 1, Boiled in iron pan, slow fire decocts 50 minutes, takes cooking liquor standby；

Step 3: the hedgehog heart, snakeskin, spiceleaf, cicada slough, baking and banking up with earth, being ground into fine powder, add the mixed stirring of Mel, obtain Blending honey is starched；The weight ratio of the Mel and fine powder is 2:1；

Step 4: by Roots of Peanut, eggplant root, mulberry leaf co-grinding, it is added in cooking liquor obtained by step 2, with equivalent ethanol Mixing, flow back 30 minutes effective component extractings, collects phegma, is condensed into paste；

Step 6: lanatechead saussurea herb with flower, Common St.Paulswort Herbs, barrenwort, lycopodium calvatum, safflower, sealwort, withy, ginger and radix glycyrrhizae, through powder It is broken, ultramicro grinding, obtain the ultra-micro powder that particle diameter is 10 μm；

Step 8: adding auxiliary material into effective component of chinese medicine obtained by step 7, Wind-dispelling ointment is produced to obtain；The auxiliary material and Chinese medicine The weight ratio of active ingredient is 1.2：1, the auxiliary material is, the mixing of sesame oil, glycerine, lauryl sodium sulfate and azone Thing；Its weight ratio is 6:1:0.2:0.05.

Embodiment 3

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are 90 parts of lanatechead saussurea herb with flower, the hedgehog heart 90,70 parts of Roots of Peanut, pepper bar 70 60 parts of Fen , Common St.Paulswort Herbs, 60 parts of barrenwort, 50 parts of lycopodium calvatum, 50 parts of eggplant root, 45 parts of snakeskin, 45 parts of spiceleaf, 30 parts of cicada slough, garlic 25 parts, mulberry leaf 20-30 parts, 25 parts of safflower, 25 parts of sealwort, 15 parts of withy, 6 parts of 5 parts of ginger and radix glycyrrhizae.

Its preparation method, comprise the following steps：

Step 2: pepper bar is cleaned, is cut into 2.5 centimetres of segments, soaked 55 minutes in snow-broth obtained by step 1, in iron Boiled in pot, slow fire decocts 40 minutes, takes cooking liquor standby；

Step 3: the hedgehog heart, snakeskin, spiceleaf, cicada slough, baking and banking up with earth, being ground into fine powder, add cercis nectar to mix, obtain mixed Close honey slurry；The weight ratio of the cercis nectar and fine powder is 1.5:1；

Step 4: by Roots of Peanut, eggplant root, mulberry leaf co-grinding, it is added in cooking liquor obtained by step 2, with equivalent ethanol Mixing, flow back 25 minutes effective component extractings, collects phegma, is condensed into paste；

Step 6: lanatechead saussurea herb with flower, Common St.Paulswort Herbs, barrenwort, lycopodium calvatum, safflower, sealwort, withy, ginger and radix glycyrrhizae, through powder It is broken, ultramicro grinding, obtain the ultra-micro powder that particle diameter is 9 μm；

Step 8: adding auxiliary material into effective component of chinese medicine obtained by step 7, Wind-dispelling ointment is produced to obtain；The auxiliary material and Chinese medicine The weight ratio of active ingredient is 1.1：1；The auxiliary material is, the mixing of sesame oil, glycerine, lauryl sodium sulfate and azone Thing；Its weight ratio is 5-6:0.5-1:0.1-0.2:0.05.

Embodiment 4

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are 85 parts of lanatechead saussurea herb with flower, the hedgehog heart 85,65 parts of Roots of Peanut, pepper bar 65 55 parts of Fen , Common St.Paulswort Herbs, 55 parts of barrenwort, 45 parts of lycopodium calvatum, 45 parts of eggplant root, 40 parts of snakeskin, 40 parts of spiceleaf, 25 parts of cicada slough, garlic 22 parts, 22 parts of mulberry leaf, 22 parts of safflower, 22 parts of sealwort, 12 parts of withy, 4 parts of 4 parts of ginger and radix glycyrrhizae.

Its preparation method, comprise the following steps：

Step 2: pepper bar is cleaned, is cut into 2 centimetres of segments, soaked 58 minutes in snow-broth obtained by step 1, in iron pan In boil, slow fire decocts 45 minutes, takes cooking liquor standby；

Step 3: the hedgehog heart, snakeskin, spiceleaf, cicada slough, baking and banking up with earth, being ground into fine powder, add honey to mix, honeybee must be mixed Honey slurry；The weight ratio of the honey and fine powder is 2:1；The honey be sophorae honey, Mel and cercis nectar with etc. weight ratio Mixing；

Step 4: by Roots of Peanut, eggplant root, mulberry leaf co-grinding, it is added in cooking liquor obtained by step 2, with equivalent ethanol Mixing, flow back 28 minutes effective component extractings, collects phegma, is condensed into paste；

Step 8: adding auxiliary material into effective component of chinese medicine obtained by step 7, Wind-dispelling ointment is produced to obtain；The auxiliary material and Chinese medicine The weight ratio of active ingredient is 1.2：1；The auxiliary material is, the mixing of sesame oil, glycerine, lauryl sodium sulfate and azone Thing；Its weight ratio is 5.6:0.8:0.16:0.05.

Embodiment 5

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are 95 parts of lanatechead saussurea herb with flower, the hedgehog heart 95,75 parts of Roots of Peanut, pepper bar 75 65 parts of Fen , Common St.Paulswort Herbs, 65 parts of barrenwort, 55 parts of lycopodium calvatum, 55 parts of eggplant root, 50 parts of snakeskin, 50 parts of spiceleaf, 35 parts of cicada slough, garlic 28 parts, 28 parts of mulberry leaf, 28 parts of safflower, 28 parts of sealwort, 18 parts of withy, 6 parts of 6 parts of ginger and radix glycyrrhizae.

Its preparation method, see embodiment 3.

Embodiment 6

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are 85 parts of lanatechead saussurea herb with flower, the hedgehog heart 95,68 parts of Roots of Peanut, pepper bar 72 58 parts of Fen , Common St.Paulswort Herbs, 60 parts of barrenwort, 55 parts of lycopodium calvatum, 45 parts of eggplant root, 43 parts of snakeskin, 48 parts of spiceleaf, 28 parts of cicada slough, garlic 26 parts, 27 parts of mulberry leaf, 26 parts of safflower, 27 parts of sealwort, 16 parts of withy, 4 parts of 6 parts of ginger and radix glycyrrhizae.

Its preparation method, see embodiment 3.

Embodiment 7

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are 86 parts of lanatechead saussurea herb with flower, the hedgehog heart 87,66 parts of Roots of Peanut, pepper bar 70 61 parts of Fen , Common St.Paulswort Herbs, 62 parts of barrenwort, 48 parts of lycopodium calvatum, 49 parts of eggplant root, 48 parts of snakeskin, 44 parts of spiceleaf, 29 parts of cicada slough, garlic 23 parts, 24 parts of mulberry leaf, 23 parts of safflower, 28 parts of sealwort, 13 parts of withy, 5 parts of 4 parts of ginger and radix glycyrrhizae.

Its preparation method, see embodiment 3.

Embodiment 8

A kind of saussurea involucrata Wind-dispelling ointment, the bulk drug are 80 parts of lanatechead saussurea herb with flower, the hedgehog heart 100,60 parts of Roots of Peanut, pepper bar 70 55 parts of Fen , Common St.Paulswort Herbs, 50 parts of barrenwort, 45 parts of lycopodium calvatum, 50 parts of eggplant root, 30 parts of snakeskin, 60 parts of spiceleaf, 30 parts of cicada slough, garlic 25 parts, 20 parts of mulberry leaf, 25 parts of safflower, 26 parts of sealwort, 20 parts of withy, 3 parts of 8 parts of ginger and radix glycyrrhizae.

Its preparation method, see embodiment 3.

Comparative example 1

The technical scheme of comparative example 1 and embodiment 3 is essentially identical, and its difference is, removes the Chinese medicinal ingredients hedgehog heart.

Comparative example 2

Comparative example 2 is substantially the same manner as Example 3, its difference is, by traditional Chinese medicine ingredients barrenwort with etc. parts by weight Pilose antler substitutes.

Comparative example 3

Comparative example 3 is substantially the same manner as Example 3, and its difference is, the Chinese medicinal ingredients lopseed of 80 parts of increase.

Comparative example 4

With the formula pharmacy of the Chinese patent embodiment 1 of Application No. 201510042211.6.

Comparative example 5

Comparative example 5 is substantially the same manner as Example 3, and its difference is, snow-broth is replaced with light water.

Comparative example 6

Comparative example 6 is substantially the same manner as Example 3, and its difference is, removal step two, and pepper bar is placed in into former step Extraction is mixed in four.

Clinical data：

1. diagnostic criteria

Diagnostic criteria of the Western medicine diagnostic criteria with reference to American society of rheumatism ARA revisions in 1987：1. morning stiffness at least 1h (is held Continuous time >=6 week)；2. 3 or more than 3 swollen joints (duration >=6 week)；3. wrist, metacarpophalangeal joints or near-end finger tip joint Swollen (duration >=6 week)；4. symmetry arthritis (duration >=6 week)；5. subcutaneous nodule；6. hand x-ray changes；7. class wind Wet factor positive (titre>1∶32).There are 4 persons in above-mentioned 7 to be diagnosed as rheumatoid arthritis.

The medical diagnosis on disease of the tcm diagnosis standard traditional Chinese medical science and syndrome diagnostic criterion reference《New Chinese medicine treats rheumatoid arthritis Guideline of clinical investigations》And clinical practice is combined, formulate syndrome diagnostic criterion.

2. general information

Case all cases come from outpatient service and the inpatient in certain hospital of traditional Chinese hospital, totally 700.It is randomly divided into 14 groups：Control Treatment group 50 × 8, control group 50 × 6.

3. treatment method

Treatment group：Ointment prepared by the embodiment of the present invention 3 is applied to, and assistant massaging is to there is warmth sensation, with gauze or Medical adhesive tape swathes, and according to the state of an illness, applies 3-5 times daily, 15 days are a course for the treatment of.

Control group：Treated according to medication successively is formulated described in comparative example 1-6.

Two groups of equal Ureteral Calculus of patient 3 months.

4. evaluation of clinical curative effect standard

At the end of the course for the treatment of, joint swelling index, articular pain index, morning stiffness, grip, ESR, RF are examined, each The improvement degree of index is calculated as follows：

Value × 100% before (being worth before treatment after value-treatment)/treatment；

ESR is calculated：

(being worth before treatment after value-treatment)/(value-normal value before treatment) × 100%；Male normal value is less than or equal to 15mm/hr, Female is less than or equal to 20mm/hr.

Curative effect is classified：

The improvement percentage of indices is calculated, addition, which calculates it, averagely improves percentage to judge curative effect.

It is effective：Before comparing treatment after treatment, improvement rate >=70%.

Effectively：Before comparing treatment after treatment, 50%≤improvement rate ＜ 70%.

Improve：Before comparing treatment after treatment, 30%≤improvement rate ＜ 50%.

It is invalid：Before comparing treatment after treatment, improvement rate ＜ 30%.

Total effective rate=obvious effective rate+effective percentage+improvement rate.

5. treatment results

After treatment one month, efficacy result is shown in Table 1.

Table 1, therapeutic effect

The therapeutic effect of table 1 is prompted, and the effective percentage of each embodiment for the treatment of group is 100%, is significantly better than control group.It can be seen that Invention Chinese medicine has the advantages of evident in efficacy, total effective rate is high.And effective+effectively=number of cases of embodiment, effect are the most prominent. Treatment group and control group are showed no adverse reaction simultaneously.

1. patient Mr. Wang, female, 58 years old, self-induction suffered from rheumatoid arthritis 3 years, rear both hands joint is felt nervous from having morning, stiff Firmly, alleviate after activity, the multiple articulations digitorum manus congestion and swelling pains of both hands, biped big toe joint congestion and swelling pain, hand x-ray change etc. is accused of.Through After being diagnosed as rheumatoid arthritis, give the ointment of the preparation of the embodiment of the present invention 3, smear affected part, smear later with gauze or Person's medical adhesive tape swathes, once in the morning and once at night.Congestion and swelling pain disappears after 10 days, from morning after still slightly have morning stiffness sense, after treatment 30 days, on Symptom is stated all to disappear.After drug withdrawal, follow-up is not recurred for 5 months.

2. patient Zhang, man, 60 years old, private prosecution suffered from rheumatoid arthritis 10 years, double knee joint becomes row, in great pain, walks Road is difficult, it is necessary to by crutch, aggravates rainy days.Once took western medicine to have a surplus for 2 years, and be discontinued and recur, also used pin The methods of moxibustion, physiotherapy, treats, but curative effect is little.Through procuratorial work patient's double knee joint joint stuffiness, x ray photograph excludes osteopathy.Through true Examine after rheumatoid arthritis, to give the ointment of the preparation of the embodiment of the present invention 4, smear affected part, after smearing with gauze or Medical adhesive tape swathes, four times per day.Patient's double knee joint pain relief after 15 days, crutch can be departed from, freedom of movement, be reduced to every It once in the morning and once at night, treatment 30 days after, pain is wholly absent, freedom of movement.Then 2 courses for the treatment of of after treatment.After drug withdrawal, follow-up 3 Do not recur within individual month.

Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, this area is common Other modifications or equivalent substitution that technical staff is made to technical scheme, without departing from technical solution of the present invention Spirit and scope, all should cover among scope of the presently claimed invention.

Claims

1. a kind of saussurea involucrata Wind-dispelling ointment, it is characterised in that the bulk drug is lanatechead saussurea herb with flower 80-100 parts, hedgehog heart 80-100, peanut Root 60-80 parts, pepper bar 60-80 Fen , Common St.Paulswort Herb 50-70 parts, barrenwort 50-70 parts, lycopodium calvatum 40-60 parts, eggplant root 40-60 Part, snakeskin 30-60 parts, spiceleaf 30-60 parts, cicada slough 20-40 parts, garlic 20-30 parts, mulberry leaf 20-30 parts, safflower 20-30 parts, Sealwort 20-30 parts, withy 10-20 parts, ginger 3-8 parts and radix glycyrrhizae 3-8 parts.

2. saussurea involucrata Wind-dispelling ointment according to claim 1, it is characterised in that the bulk drug is lanatechead saussurea herb with flower 85-95 parts, thorn Hedgehog heart 85-95, Roots of Peanut 65-75 parts, pepper bar 65-75 Fen , Common St.Paulswort Herb 55-65 parts, barrenwort 55-65 parts, lycopodium calvatum 45-55 Part, eggplant root 45-55 parts, snakeskin 40-50 parts, spiceleaf 40-50 parts, cicada slough 25-35 parts, garlic 22-28 parts, mulberry leaf 22-28 parts, hide Safflower 22-28 parts, sealwort 22-28 parts, withy 12-18 parts, ginger 4-6 parts and radix glycyrrhizae 4-6 parts.

3. saussurea involucrata Wind-dispelling ointment according to claim 1, it is characterised in that the bulk drug is 90 parts of lanatechead saussurea herb with flower, the hedgehog heart 90,70 parts of Roots of Peanut, 60 parts of the Fen , Common St.Paulswort Herbs of pepper bar 70,60 parts of barrenwort, 50 parts of lycopodium calvatum, 50 parts of eggplant root, 45 parts of snakeskin, 45 parts of spiceleaf, 30 parts of cicada slough, 25 parts of garlic, 25 parts of mulberry leaf, 25 parts of safflower, 25 parts of sealwort, 15 parts of withy, 5 parts of ginger and sweet 6 parts of grass.

4. a kind of preparation method according to any one of the claim 1-3 Wind-dispelling ointments, it is characterised in that comprise the following steps：

Step 1: collect winter snows dress is embedded in underground in a reservoir, Second Year spring takes out the snow-broth that snow melt obtains, standby；

Step 2: pepper bar is cleaned, is cut into 2-3 centimetres of segment, 50-60 minutes are soaked in snow-broth obtained by step 1, in iron Boiled in pot, slow fire decocts 30-50 minutes, takes cooking liquor standby；

Step 3: the hedgehog heart, snakeskin, spiceleaf, cicada slough, baking and banking up with earth, being ground into fine powder, add honey to mix, obtain blending honey slurry； The weight ratio of the honey and fine powder is 1-2:1；

Step 4: by Roots of Peanut, eggplant root, mulberry leaf co-grinding, it is added in cooking liquor obtained by step 2, is mixed with equivalent ethanol Close, flow back 20-30 minute effective component extractings, collects phegma, is condensed into paste；

Step 5: garlic is wrapped up with clay, be placed in calcination in convulsive seizure due to phlegm-fire, to burned taste is smelt, divest gelling, take out burnt garlic, It is ground into fine powder；

Step 6: lanatechead saussurea herb with flower, Common St.Paulswort Herbs, barrenwort, lycopodium calvatum, safflower, sealwort, withy, ginger and radix glycyrrhizae, through crushing, surpass Crushing of Ultrafine, obtain the ultra-micro powder that particle diameter is 8-10 μm；

Step 7, by paste obtained by garlic coke powder obtained by ultra-micro powder obtained by step and step 6, step 5, step 4 and Blending honey slurry is well mixed；Obtain the Chinese medicinal ingredients of Wind-dispelling ointment；

Step 8: adding auxiliary material into effective component of chinese medicine obtained by step 7, Wind-dispelling ointment is produced to obtain；The auxiliary material and Chinese medicine are effective The weight ratio of composition is 1-1.2：1.

5. preparation method according to claim 4, it is characterised in that the honey is sophorae honey, Mel or bauhinia One or more kinds of mixtures in honey.

6. preparation method according to claim 4, it is characterised in that the auxiliary material is sesame oil, glycerine, dodecyl sulphur The mixture of sour sodium and azone；Its weight ratio is 5-6:0.5-1:0.1-0.2:0.05.