CN1843421A - Rheumatoid disease treating medicine - Google Patents
Rheumatoid disease treating medicine Download PDFInfo
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- CN1843421A CN1843421A CNA2005100658040A CN200510065804A CN1843421A CN 1843421 A CN1843421 A CN 1843421A CN A2005100658040 A CNA2005100658040 A CN A2005100658040A CN 200510065804 A CN200510065804 A CN 200510065804A CN 1843421 A CN1843421 A CN 1843421A
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Abstract
The invention discloses a medicament for treating rheumatic diseases, which is prepared from ledebouriella root, notopterygium root, large-leaf gentian root, cassia twig, tetrandra root, long-nosed pit viper, Clematis chinensis, prepared Sichuan aconite root, rhizome of Sichuan lovage, red sage root, pangolin scales, cow-bezoar, earthworm, root bark of tree peony, leeches, astragalus root, Chinese angelica root, poria cocos and atractylodes rhizome.
Description
[technical field]
The present invention relates to a kind of medicine for the treatment of rheumatism, belong to the field of Chinese medicines.
[background technology]
Rheumatism is called arthromyodynia in the traditional Chinese medical science.Numbness is the obstructed meaning of impatency.After human body flesh table meridians suffer exopathogen invasion and attack, make fate capable not smooth, cause the aching of limbs, joint, muscle, numb, disease such as focus on, be called arthromyodynia.In western medicine, be called rheumatic arthritis, rheumatoid arthritis, gout etc.Rheumatism, complex genesis, common with old people Yi Fa especially, whenever climate change, especially overcast and rainy cold snap, symptom is obvious, and the pain increased, and patient's uneasy in either sitting or lying is very painful.At present, the proved recipe of the rheumatism that heals with medicine is more, though it has certain curative effect to rheumatism, existing Chinese medicine preparation still exists curative effect unhappy, and bounce-back is difficult to deficiencies such as radical cure easily, and is still unsatisfactory.
[summary of the invention]
For a long time, there is urgent needs in people's medicine that curative effect is better treated rheumatism.Up to now, also do not find the report of relevant drug compound preparation of the present invention.The inventor is through research repeatedly, and the checking repeatedly by long-term practice and clinical trial, has found the compound Chinese medicinal preparation that the treatment of better curative effect rheumatism is arranged finally, thereby has finished the present invention.
Purpose of the present invention just provides a kind of medicine of more effectively treating rheumatism, and particularly a kind of treatment rheumatism is easy fast, and once healing, the compound Chinese medicinal preparation that is difficult to recur.
For achieving the above object, the present invention is realized by following technical proposals.A kind of medicine for the treatment of rheumatism is the medicament of being made by the following traditional Chinese medicine raw weight proportion:
Radix Saposhnikoviae 5-15g Rhizoma Et Radix Notopterygii 5-10g Radix Gentianae Macrophyllae 5-15g Ramulus Cinnamomi 5-12g
Radix Stephaniae Tetrandrae 5-15g Agkistrodon 5-10g Radix Clematidis 5-15g Radix Aconiti Preparata 5-10g
Rhizoma Chuanxiong 5-15g Radix Salviae Miltiorrhizae 5-15g Squama Manis 5-10g cattle lacquer 5-15g
Pheretima 5-15g Cortex Moutan 5-15g Hirudo 2-10g Radix Astragali 10-20g
Radix Angelicae Sinensis 5-15g Poria 5-15g Rhizoma Atractylodis 5-15g
A kind of its preferred weight proportioning of medicine for the treatment of rheumatism of the present invention is:
Radix Saposhnikoviae 10g Rhizoma Et Radix Notopterygii 6g Radix Gentianae Macrophyllae 10g Ramulus Cinnamomi 8g
Radix Stephaniae Tetrandrae 10g Agkistrodon 5g Radix Clematidis 10g Radix Aconiti Preparata 6g
Rhizoma Chuanxiong 10g Radix Salviae Miltiorrhizae 12g Squama Manis 6g cattle lacquer 10g
Pheretima 10g Cortex Moutan 8g Hirudo 3g Radix Astragali 15g
Radix Angelicae Sinensis 10g Poria 10g Rhizoma Atractylodis 9g
Medicine of the present invention adopts fried one-tenth Chinese medicine decoction for oral administration usually.Also can adopt the conventional method of Chinese medicine preparation to be prepared into multiple conventional oral preparations.For example above-mentioned formula material medicine pulverize mix homogeneously can be made pill or capsule.
The rheumatism traditional Chinese medical science is called arthromyodynia, and doctor trained in Western medicine is called rheumatic arthritis.Be divided into migratory arthralgia according to its origin cause of formation, doctor trained in Western medicine is called acute rheumatic arthritis; Arthralgia due to cold, doctor trained in Western medicine is called chronic rheumatic arthritis; Arthralgia chiefly caused by damp pathogen, doctor trained in Western medicine is called osteoarthrisis deformans knee.Migratory arthralgia is the disease that wind-engaging breaks out afterwards.Originally this disease can make people's mistake be flu, and the whole body was uncomfortable before this, lassitude, and the larynx redness, canthus dull pain, and stretching uncomfortable phenomenon in joint is arranged.During outbreak, joint component redness, distending pain, particularly two bone coupling parts are the most violent, stretch and bend inconvenience, and the finger toes lose normality.This disease has high thermal phenomenon, and other rheumatism does not have, and this is the most significantly symptom of migratory arthralgia.Arthralgia due to cold, this disease oncoming force is more slow, does not have cold and heat again, and only small number of patients has cold and heat, but temperature is humble.A part is to be changed by migratory arthralgia, and a part is to begin promptly disease for this reason.This disease is from the beginning of, joint portion branch mild pain, and crooked inconvenience has strong state, and pain gradually can come in undiscipline, makes to be between skin and the joint and burns phenomenon, and of a specified duration then transferring to has an intense pain, and brings the tears to one's eyes.Arthralgia chiefly caused by damp pathogen, comprehensive each type of this disease, doctor trained in Western medicine also claims multiple rheumatism.Often show effect season with dampness, in the course of time, joint component can not be stretched by song, and enlargement, the reason that this disease forms, mainly be at ordinary times malnutrition, vim and vigour weak due to, the evil that the patient who also has endures rheumatism in one's early years to the fullest extent forms.In addition, in rheumatism, a kind of cause of disease is not bright to be that the main chronic general immunity disease that shows then is called rheumatoid arthritis with the polyarthritis, is prone to ankylosis and deformity its late period.In a word, rheumatism, complex genesis, but after being human body flesh table meridians and suffering exopathogen invasion and attack, make fate capable not smooth, cause the aching of limbs, joint, muscle, numb, disease such as focus on.A kind of medicine for the treatment of rheumatism of the present invention is to cure the method for rheumatism according to motherland's tradition, extensively collects the folk secret folk prescription, develops in conjunction with the modern medicine study achievement and through long-term practice application repeated screening.The compound Chinese medicinal preparation medicine that Chinese medicine composition of the present invention selects Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Gentianae Macrophyllae, Ramulus Cinnamomi, Radix Stephaniae Tetrandrae, Agkistrodon, Radix Clematidis, Radix Aconiti Preparata, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Squama Manis, cattle lacquer, Pheretima, Cortex Moutan, Hirudo, the Radix Astragali, Radix Angelicae Sinensis, Poria, Rhizoma Atractylodis combination to make, can make each efficacy of drugs produce synergism, thereby can effectively treat rheumatism fast.
Select for use Radix Saposhnikoviae to be among the side of the present invention because Radix Saposhnikoviae property acrid-sweet flavor tepor has inducing diaphoresis to dispel wind, removing dampness to relieve pain ends the effect through antidiarrheal; The arduous temperature of Rhizoma Et Radix Notopterygii, the cold expelling that induces sweat, removing dampness to relieve pain; The Radix Gentianae Macrophyllae toil is flat, wind-damp dispelling, Shujin network, clearind deficient heat; Ramulus Cinnamomi Xin Ganwen, diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI; The Radix Stephaniae Tetrandrae toil is cold, wind-expelling pain-stopping, inducing diuresis to remove edema; The sweet salty temperature of Agkistrodon, expel wind to dredge collateral, relieving spasm by subduing liver-wind, counteracting toxic substances is antipruritic; The hot salty temperature of Radix Clematidis, expelling wind and removing dampness, removing obstruction in the collateral to relieve pain; The hot salty temperature of Radix Aconiti Preparata, expelling wind and removing dampness, dispersing cold for relieving pain, narcotic analgesic.More than the pharmacodynamic feature of one group of eight flavor medicine be mainly inducing diaphoresis to dispel wind, removing dampness to relieve pain helps the function of Radix Saposhnikoviae expelling wind and removing dampness altogether.
In order to reach better therapeutic, medicine of the present invention also makes up with Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Squama Manis, cattle lacquer, Pheretima, Cortex Moutan, Hirudo.At this moment because the Rhizoma Chuanxiong property and flavor of peppery and warm has blood-activating and qi-promoting, the effect of dispelling wind and removing obstruction in the collateral, menstruction regulating and pain relieving; The Radix Salviae Miltiorrhizae hardship is slightly cold, stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, removing heat from blood detumescence; Squama Manis is salty to be slightly cold, promoting blood circulation to restore menstrual flow, detumescence and apocenosis; It is flat that cattle is coated with lacquer bitter sweet acid, blood circulation promoting and blood stasis dispelling, sharp joint, strong waist knee joint, the conducting blood to flow downwards of igniting; Pheretima is salty-cold, promoting blood circulation to remove obstruction in the collateral, suppressing the hyperactive liver to relieve the wind syndrome, clearing heat and relieving dyspnea; The Cortex Moutan toil is slightly cold, promoting blood circulation to remove blood stasis, clearing away heat and cooling blood; The salty hardship of Hirudo is flat, removing blood stasis, removing blood stasis stimulates the menstrual flow, more than seven medicines focus on promoting blood circulation to restore menstrual flow, common assistant helps the monarch and his subjects' the product blood stasis dispelling that dehumidifies, and the merit of activating collaterals to relieve pain is arranged again.
In order to obtain optimum curative effect, medicine of the present invention also can add the Radix Astragali, Radix Angelicae Sinensis, Poria, Rhizoma Atractylodis combination on the basis of said medicine.At this moment because Radix Astragali nature and flavor are sweet to be slightly cold, has tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, the effect of inducing diuresis to remove edema; Radix Angelicae Sinensis Gan Xinwen enriches blood and invigorates blood circulation, loosening bowel to relieve constipation, menstruction regulating and pain relieving, clearing heat and relieving dyspnea; Poria is sweet light flat, spleen-benefiting mind-tranquilizing, and diuretic wins wet; The arduous temperature of Rhizoma Atractylodis, drying damp and strengthening spleen, expelling wind and removing dampness, diaphoresis makes eye bright.More than four medicines focus on to enrich blood and foster the spirit of nobility, spleen-benefiting mind-tranquilizing is aided with the merit of expelling wind and removing dampness simultaneously.
This shows that medicine of the present invention makes up 19 flavor medicines among the above-mentioned side, particularly with the described weight proportion combination of prescription, its expelling wind and removing dampness promoting blood circulation to restore menstrual flow and QI invigorating pain relieving effect are stronger, curative effect the best of treatment rheumatism.The preferred preparation of recipe drug of the present invention is suited the remedy to the case, and specificity is strong, is pure Chinese medicine, and is evident in efficacy to the rheumatism treatment fast, once healing, is difficult to recurrence.
Medicine of the present invention, raw material is easily got, taking convenience.It is for oral administration that medicine of the present invention is pressed the fried one-tenth Chinese medicine decoction of the conventional decocting method of Chinese medicine usually.General patient takes 7 days courses of treatment 7 pairs of Chinese medicines and can cure, and severe patient takes and can be clearly better 2-10 the course of treatment, and can cure, and once healing, is difficult to later on recur.Medicine of the present invention can be made into pill or capsule, called after " quick-acting rheumatic spirit " temporarily when producing in batches.Medicine of the present invention is two more than ten years of clinical practice, successively treat all kinds of rheumatisants people more than 660, effective percentage 97%, cure rate 88%.
In sum, a kind of medicine for the treatment of rheumatism of the present invention has following characteristics: the one, and selected medical material, evident in efficacy.This medicine is extensively being collected on the secret recipe folk prescription basis, and the pure Chinese medicine of screening 19 flavors is suited the remedy to the case in long-term practice is used, and specificity is strong, the effect uniqueness.The 2nd, taking convenience, quick result.This medicine adopts fried Chinese medicine decoction for oral administration usually, also can be made into pill or capsule, relative short treating period, good effect.The 3rd, treating both the principal and secondary aspects of a disease is difficult to recurrence.This medicine cures mainly rheumatism, is aided with the effect of qi-tonifying health-care simultaneously, once healing, is difficult to recurrence.The 4th, raw material is easily got, promise well.This medicine is common easily to be got, and preparation easily, suitable batch production.Rheumatism particularly, Yi Fa and common especially with old man's sickness rate height, does not still have desirable specific drug to radical cure rheumatism medicine circle at present, short treating period of the present invention, good effect will become the innovation medicine that market in urgent need is filled a vacancy, and market potential is big, and development prospect is good.
[specific embodiment]
Below further sets forth the beneficial effect of medicine of the present invention by drug test example and Drug therapy example, these tests comprise that the clinical observation on the therapeutic effect of medicine of the present invention tests and specifically treat the case brief introduction.
The clinical observation of [test example 1] Drug therapy rheumatism of the present invention
1, basic condition
1999 to 2003, diagnosis and treatment rheumatism patient 228 examples, wherein male 80 examples, women 148 examples; Age 21-30 year 7 examples, 31-40 year 16 examples, 41-50 year 41 examples, 51-60 year 57 examples, 61-70 year 80 examples, 27 examples more than 71 years old; Peasant 114 people, cadre 23 people, teacher 46 people, worker 36 people, other 9 people.Various rheumatisant's classification have: migratory arthralgia (acute rheumatic arthritis) 83 examples, arthralgia due to cold (chronic rheumatic arthritis) 79 examples, arthralgia chiefly caused by damp pathogen (osteoarthrisis deformans knee) 23 examples, rheumatoid 32 examples, other rheumatism 11 examples.The course of disease is the longest 25 years, the shortest 15 days.
2, diagnostic criteria
The rheumatism patient is pressed medical science universal standard diagnostic classification.Can be referring to the described relevant concrete diagnostic classification standard of this description.
3, Therapeutic Method
For oral administration by the fried Chinese medicine decoction of prescription of the present invention.Decoct secondary 1 pair of every day, and the morning and evening are for oral administration, 7 days courses of treatment, treats elder and took continuously three months, be i.e. 13 courses of treatment.
4, criterion of therapeutical effect
Produce effects: various rheumatism patients are after treatment, and are intact normal, continue to observe 6 months no recidivists.
Take a turn for the better: the state of an illness is able to basic controlling, starts from improvement.
Invalid: as not reach above-mentioned improvement standard person.
5, therapeutic outcome (see Table 1 and table 2)
Table 1 is observation of curative effect behind the treatment rheumatism
| Treatment time (my god) | Produce effects | Take a turn for the better | Invalid | Effective percentage | |||
| The example number | Obvious effective rate | The example number | Improvement rate | The example number | Inefficiency | ||
| 15 | 141 | 62％ | 37 | 16％ | 50 | 22％ | 78％ |
| 30 | 173 | 76％ | 21 | 9％ | 34 | 15％ | 85％ |
| 60 | 196 | 86％ | 14 | 6％ | 18 | 8％ | 91％ |
| 90 | 210 | 92％ | 12 | 5％ | 6 | 3％ | 97％ |
Table 2 is through treating three months various rheumatism observation of curative effect
| The rheumatism classification | Migratory arthralgia | Arthralgia due to cold | Arthralgia chiefly caused by damp pathogen | Rheumatoid | Other rheumatism |
| Case before the treatment | 83 | 79 | 23 | 32 | 11 |
| Treatment back case | 0 | 2 | 1 | 2 | 1 |
| Total effective rate | 100％ | 98％ | 96％ | 93％ | 97％ |
Show from table 1 observation of curative effect result, to rheumatism patient treatment 3 months, observe 6 middle of the month, with its treatment rheumatism of medicine of the present invention patient 228 examples, produce effects 210 examples as a result, obvious effective rate is 82%, 12 examples that take a turn for the better, improvement rate is 5%, invalid 6 examples, inefficiency is 3%, and total effective rate reaches 97%.
Show from table 2 observation of curative effect result, medicine of the present invention is through treating trimestral observation of curative effect to various rheumatism patient 228 examples, the result is 100% to the migratory arthralgia total effective rate, to the arthralgia due to cold total effective rate is 98%, to the arthralgia chiefly caused by damp pathogen total effective rate is 96%, to rheumatoid disease arthritis total effective rate is 93%, is 97% to other rheumatism total effective rate.
Further set forth instructions of taking and the preparation method and the treatment curative effect thereof of medicine of the present invention below by embodiment.
The fried Chinese medicine decoction instructions of taking of [instructions of taking 1] medicine of the present invention
Chinese medicine decoction is the liquid preparation that forms through decocting.Medicine of the present invention is assorted by prescription, decocted with marmite or sand jar.During decoction, water will cover powder 2-3 centimetre, treat water boil after, fry in shallow oil again with low baking temperature and to get final product in 20-30 minute.When decocting for the second time, the water yield needs only crosses powder slightly, boils to get final product in 15 minutes.Usually take 1 pair every day, should divide the morning and evening secondary after meal half an hour decoction being taken warmly.
[preparation method 1] bolus of drug preparation method of the present invention
19 flavor medicated powder in the pharmaceutical preparation of the present invention are broken into fine powder, sieve mixing.Every 100g powder adds the close 100-110g of refining and makes binding agent, makes close ball with rubbing the ball method with the hands, and heavy 1-3g packs with paraffin paper.In addition, also available water is made binding agent, makes the watered pill with agitation procedure, cold drying, that is and, per 100 nearly weigh 3g.Use the vial splendid attire.
[preparation method 2] medicament capsule preparation method of the present invention
19 flavor medicines in the pharmaceutical preparation of the present invention are decocted with water twice; each amount of water was not advisable to have powder; merge decocting liquid twice, filter gained filtrate, be condensed into proportion and be 1.35 extractum; add 90%-95% ethanol and carry out precipitate with ethanol; reclaim ethanol and concentrated, dry under 45-50 ℃, make dry extract; it is ground into fine particle or powder, the snap fit capsule of packing into.
[embodiment 1-5]
Example 1 Xu likes lotus, woman, 61 years old, 3 groups in Xinning County, Hunan Province Baima Tian Cunjin west village.Rheumatic arthritis, knee joint swells and ache, and dim eyesight is unable, does not heal through how tame hospitalize over 5 years.In JIUYUE, 1999 is taken 15 pairs of medicines of the present invention, gets to cure.
2 woods mid-autumns of example, woman, 52 years old, Jin Xi village, Bai Matian township, Xinning County, Hunan Province.Rheumatoid arthritis, arthralgia, dizziness and blurred vision was fallen ill 2 years, at county hospital two wheat harvesting periods of being in hospital, successively spent 1.5 ten thousand yuan of medical fees and failed to cure.Take 35 pairs of medicines of the present invention August calendar year 2001, fully recover.
Example 3 Liu Xu are shining, man, 36 years old, the village of wafing greatly, Fei Xianqiao township, Xinning County, Hunan Province.Suffered from rheumatic arthritis 15 days, and took 7 pairs of medicines of the present invention in November, 2002, recovery from illness.
Example 4 Li Mingzhen, woman, 57 years old, metal and stone town, Xinning County, Hunan Province.Suffered from rheumatism 3 years, dizziness, abdominal distention, numb limbs and tense tendons, distending pain is unable, and Changes in weather increases the weight of, and seek medical advice and fail to cure in many places.Take 55 pairs of medicines of the present invention and fully recover in August, 2003.
Example 5 Liu Mei lotuses, woman, 42 years old, auspicious first village, metal and stone town, Xinning County, Hunan Province.Migratory rheumatism disease, lumbago, arthralgia were not cured in 6 years.In JIUYUE, 2004 is taken 25 pairs of medicines of the present invention, fully recovers.
Claims (2)
1, a kind of medicine for the treatment of rheumatism is characterized in that it mainly is to be made by following materials of weight proportions medicine: Radix Saposhnikoviae 5-15g, Rhizoma Et Radix Notopterygii 5-10g, Radix Gentianae Macrophyllae 5-15g, Ramulus Cinnamomi 5-12g, Radix Stephaniae Tetrandrae 5-15g, Agkistrodon 5-10g, Radix Clematidis 5-15g, Radix Aconiti Preparata 5-10g, Rhizoma Chuanxiong 5-15g, Radix Salviae Miltiorrhizae 5-15g, Squama Manis 5-10g, cattle lacquer 5-15g, Pheretima 5-15g, Cortex Moutan 5-15g, Hirudo 2-10g, Radix Astragali 10-20g, Radix Angelicae Sinensis 5-15g, Poria 5-15g and Rhizoma Atractylodis 5-15g.
2, a kind of medicine for the treatment of rheumatism according to claim 1 is characterized in that each raw material preferred weight proportioning is: Radix Saposhnikoviae 10g, Rhizoma Et Radix Notopterygii 6g, Radix Gentianae Macrophyllae 10g, Ramulus Cinnamomi 8g, Radix Stephaniae Tetrandrae 10g, Agkistrodon 5g, Radix Clematidis 10g, Radix Aconiti Preparata 6g, Rhizoma Chuanxiong 10g, Radix Salviae Miltiorrhizae 12g, Squama Manis 6g, cattle lacquer 10g, Pheretima 10g, Cortex Moutan 8g, Hirudo 3g, Radix Astragali 15g, Radix Angelicae Sinensis 10g, Poria 10g and Rhizoma Atractylodis 9g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100658040A CN1843421A (en) | 2005-04-07 | 2005-04-07 | Rheumatoid disease treating medicine |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2005100658040A CN1843421A (en) | 2005-04-07 | 2005-04-07 | Rheumatoid disease treating medicine |
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| CN1843421A true CN1843421A (en) | 2006-10-11 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670910A (en) * | 2012-05-04 | 2012-09-19 | 成都绿迪科技有限公司 | Traditional Chinese medicine formula for treating scleroderma |
| CN103495126A (en) * | 2013-10-25 | 2014-01-08 | 山东大学 | Traditional Chinese medicine composition treating rheumatism |
| CN103690673A (en) * | 2014-01-10 | 2014-04-02 | 张其波 | Formula capsules for treating rheumatism |
| CN103990085A (en) * | 2014-05-06 | 2014-08-20 | 李源 | Traditional Chinese medicine for treating rheumatoid arthritis |
| CN105998827A (en) * | 2016-06-30 | 2016-10-12 | 罗汉密 | Traditional Chinese medicine for treating rheumatism |
-
2005
- 2005-04-07 CN CNA2005100658040A patent/CN1843421A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670910A (en) * | 2012-05-04 | 2012-09-19 | 成都绿迪科技有限公司 | Traditional Chinese medicine formula for treating scleroderma |
| CN103495126A (en) * | 2013-10-25 | 2014-01-08 | 山东大学 | Traditional Chinese medicine composition treating rheumatism |
| CN103495126B (en) * | 2013-10-25 | 2014-12-10 | 山东大学 | Traditional Chinese medicine composition treating rheumatism |
| CN103690673A (en) * | 2014-01-10 | 2014-04-02 | 张其波 | Formula capsules for treating rheumatism |
| CN103990085A (en) * | 2014-05-06 | 2014-08-20 | 李源 | Traditional Chinese medicine for treating rheumatoid arthritis |
| CN105998827A (en) * | 2016-06-30 | 2016-10-12 | 罗汉密 | Traditional Chinese medicine for treating rheumatism |
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