CN1899403A - Chinese medicine preparation for treating pains and its preparing method and use - Google Patents
Chinese medicine preparation for treating pains and its preparing method and use Download PDFInfo
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Abstract
The present invention is a kind of Chinese medicine preparation prepared with safflower, drynaria rhizome, leatherleaf milletia and clematis root in certain weight proportion, and through organic solvent extraction or direct crushing and other conventional steps. The Chinese medicine preparation may be prepared into liniment, tincture, ointment, plaster and other externally applied preparation forms. Its is used in treating pain caused by hyperosteogeny, protrusion of lumbar intervertebral disc, cervical spondylopathy, etc. through being applied to the pain spot, and has high curative effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of treatment and cause Chinese medicine preparation of pain and its production and use by bone matrix hyperplasia, prolapse of lumbar intervertebral disc, cervical spondylosis, scapulohumeral periarthritis, arthritis, lumbar muscle strain, traumatic injury etc.
Background technology
Vertebra or extremities joint, the pain of muscle etc. is by bony spur, rheumatism, a variety of causes such as sprain and cause.
Bony spur is the hypertrophy hyperosteogeny that forms owing to hyperosteogeny, and how by invading in the wind-cold damp pathogen, it is obstructed and form to cause coagulation of QI-blood, and modern medicine claims osteoarthritis, and Chinese medical discrimination belongs to arthromyodynia." interior warp " claims: " wind, cold, wet three gas are assorted extremely, close and are numbness.Meeting this person with the winter is rheumatism involving the bone." pain be a kind of physiological phenomenon be again a kind of pathological reaction; each system to 30 of human body year old engenders later on that degeneration changes; skeletal system is particularly evident; the people more than 45 years old has 80% pain in various degree to occur; more than 70 years old up to 95%; have only 5% people clinical symptoms to occur, happening part is many in knee joint, hip, finger, lumbar vertebra and cervical vertebra joint.People need changing position and posture in life, when remaining unchanged for a long period of time or the drastic change meeting causes between bone and the bone and weares and teares, form pain on the basis that regression changes.Its clinical symptoms is based on the pain in part or nerve distribution area territory, doublely sees that numbness, sciatica even paralysis, joint motion are limited, and the course of disease is touching, and is bad during fashion, agonizing, often influences patient's life, in, common complaint among the elderly, frequently-occurring disease.Along with the quickening of people's rhythm of life, hyperosteogeny patient is more and more, does not still have specific short at present pain is removed.The way that doctor trained in Western medicine is generally taked to draw, diathermy or operation are rejected, but patient's human body misery, the operation of crucial hypertrophy position also is in peril of one's life, and several years pain also can recur behind the corrective surgery.
Rheumatism one speech appears on China's Huangdi's Internal Classics the earliest, is referred to as to be called numbness, is " arthromyodynia " so the traditional Chinese medical science is commonly called as rheumatoid.Rheumatism comprises the comprehensive connective tissue disease of a class that all corrode intermuscular bone ilium system and involve whole body, as joint, muscle, tendon, synovial bursa etc.It mainly is to serve as main performance with pain, swelling, is called as " not dead cancer ".Rheumatism is involved the joint mostly and is caused pain, aches, and numb, swelling, even red and swollen distortion, weight person can cause the destruction of joint sclerotin, causes joint deformity, can't take care of oneself.And mostly be chronic greatly, outbreak repeatedly, long-term excruciating disease, rheumatism are the universally acknowledged difficult disease in the world, World Health Organization (WHO) will be decided to be " joint, world buring sun " October 12 in every year.
What the joint was too quickly reverses, tears attached to joint capsule, ligament and tendon outside the joint, sprains exactly.Sprain and be most commonly in ankle joint, wrist and following waist.
More to such treatment of diseases method at present, medicine is different, though all can reach certain curative effect, Western medicine can not effect a radical cure chronic pain, or the easy one-tenth of life-time service is latent, selects the treatment by Chinese herbs unsatisfactory curative effect for use.Therefore, further improve curative effect, the new clinical treatment medicine of research and inquirement is still significant in present stage.
Flos Carthami has promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia is not all right, injury from falling down, sore, carbuncle and painful swelling.
Rhizoma Drynariae has the kidney invigorating bone strengthening, continues to hinder pain relieving.Be used for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, and the muscles and bones folding is hindered; The external treatment alopecia areata, vitiligo.
Radix Clematidis has expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Be used for rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, the bone larynx of choking with sobs.
Sanguis Gallus domesticus have enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Chinese patent CN1363364A, CN1164323C, CN1559454A, CN1410133A etc. disclose with Flos Carthami, Rhizoma Drynariae, Radix Clematidis, Caulis Spatholobi and other Chinese medicine and have prepared the Chinese medicine for the treatment of pain together, but the applicant finds in practice process, in the pharmaceutical preparation of these prior aries, other composition except that mentioned component is not significant effect in therapeutic process, and increase the toxic and side effects that Chinese medicine might increase medicine, also increased preparation cost on the other hand.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation of treatment pain of the determined curative effect of making by less Chinese medicine.
Another object of the present invention provides the preparation method of this Chinese medicine preparation.
A further object of the invention provides the purposes of this Chinese medicine preparation.
Realize that the technical scheme that first purpose of the present invention adopts is: a kind of Chinese medicine preparation for the treatment of pain, it is to be made by the Chinese medicine of following weight percentage ratio: Flos Carthami 5%～85%, Rhizoma Drynariae 5%～85%, Radix Clematidis 5%～85%, Caulis Spatholobi 5%～85%.
Above-mentioned Chinese medicine preferred Flos Carthami 25%～45%, Rhizoma Drynariae 25%～35%, Radix Clematidis 20%～30% and Caulis Spatholobi 10%～20%.
Described Chinese medicine preparation is made exterior-applied formulation, comprises sticking agent, liniment, tincture, ointment, emplastrum, cataplasma.
The wherein a kind of preparation method that realizes second purpose technical scheme of the present invention may further comprise the steps:
1. Flos Carthami, Rhizoma Drynariae, Radix Clematidis and Caulis Spatholobi are pressed the processing of medicinal material processing standard and concoct, dried and crushed becomes coarse powder;
2. above-mentioned coarse powder concentration is to carry out percolation behind soak with ethanol 40～50h of 35%～95%, collects percolate; 3. the with medicament conventional method is mixed with external preparation with above-mentioned percolate.
After 2. above-mentioned steps comprised also that the percolate that collection is obtained leaves standstill 40～50h, adding water to concentration of alcohol was 35%～55%.
The above-mentioned steps 2. speed of middle percolation is per kilogram medical material per minute 3～5ml.
The external preparation of above-mentioned steps described in 3. is for sticking agent, tincture or liniment.
The second kind of preparation method that realizes second purpose technical scheme of the present invention may further comprise the steps: 1. Flos Carthami, Rhizoma Drynariae, Radix Clematidis and Caulis Spatholobi are pressed the processing of medicinal material processing standard and concoct, dried and crushed becomes fine powder or impalpable powder; 2. the with medicament conventional method is mixed with ointment, cataplasma or emplastrum with above-mentioned fine powder, impalpable powder.
The third preparation method that realizes second purpose technical scheme of the present invention may further comprise the steps: 1. Flos Carthami, Rhizoma Drynariae, Radix Clematidis and Caulis Spatholobi are pressed the processing of medicinal material processing standard and concoct, dried and crushed becomes coarse powder; 2. the coarse powder concentration that 1. step is obtained is that 70%～95% ethanol refluxes, and collects backflow; 3. the backflow that 2. distilling under reduced pressure step obtains reclaims ethanol, and spray drying gets extract powder; 4. with medicament conventional method extract powder that 3. step is obtained is mixed with liniment, ointment, emplastrum or cataplasma.
The technical scheme that realizes the 3rd purpose of the present invention is the above-mentioned application of Chinese medicine preparation in the medicine of preparation treatment pain.The particularly application in the medicine of the pain that the various causes of disease such as preparation treatment bone matrix hyperplasia, prolapse of lumbar intervertebral disc, cervical spondylosis, scapulohumeral periarthritis, arthritis, lumbar muscle strain, traumatic injury cause.
Described coarse powder, fine powder, impalpable powder are meant the powder of making according to appendix regulation of version Chinese Pharmacopoeia in 2005.
Chinese medicine preparation using method of the present invention is: (1) wipes clean patient's skin, get of the present inventionly to stick agent, emplastrum, cataplasma and stick on pressure pain point, the next day once, sticked 2～10 hours at every turn.(2) patient's skin is wiped clean, get liniment of the present invention, tincture, ointment put on the skin be applied to pressure pain point and around, every day 3～4 times.
The present invention is through zoopery and clinical verification, and the result is as follows:
1., the mice hot plate is caused the analgesic activity of pain: test by hot plate method, the result causes the pain mice to hot plate certain analgesic activity.
2., the mice acetic acid twisting is caused the analgesic activity of pain: test by the acetic acid twisting method, local topical of the present invention only causes the pain mice to 0.6% acetic acid normal saline 0.2ml/ significant analgesia role.
3, rat uric acid sodium arthritis is caused the analgesic activity of pain: cause pain method by uric acid sodium arthritis and test, partial smearing causes scorching sufficient method administration, external of the present invention as a result has certain analgesic activity to the rat arthritis pain due to the micro-crystal type uric acid sodium, makes the gait score that causes scorching back different time that in various degree reduction be arranged.
Certain hospital is with disease 100 examples such as agent treatment hyperosteogeny, rheumatoid arthritis, chronic strain, aseptic inflammation that stick of the present invention, traumatic injury causes disease 14 examples, the different parts hyperosteogeny causes disease 57 examples, rheumatoid arthritis 3 examples, scapulohumeral periarthritis 15 examples, prolapse of lumbar intervertebral disc 11 examples.Painful area is in cervical region 17 examples, waist 23 examples, shoulder 26 examples, lower back 4 examples, extremities joint portion 22 examples, heel pain 8 examples.Male 39 examples among the above-mentioned patient, women 61 examples, the mean age is 45 years old, age reckling 10 years old, the maximum 76 years old, average disease time 7 years, the shortest is two weeks, the longest is 30 years.Use recovery from illness 48 examples behind the medicine of the present invention, produce effects 29 examples, effective 21 examples, invalid 2 examples, obvious effective rate is 77%, total effective rate reaches 98%.
Model case:
1, open * *, the man, 48 years old, certain institute factory of factory, right heel pain more than ten years, difficulty in walking, film making is seen right with 1.5 * 2cm pain, part 4 recoveries from illness of invention medicine that lose money in a business.
2, appoint * *, the woman, 52 years old, certain workman of factory, right shoulder pain 1 year, limitation of activity disappears to tenderness place 2 pain of invention medicine that lose money in a business.
The specific embodiment
Embodiment 1
Stick the preparation of agent: get Flos Carthami 23g, Rhizoma Drynariae 21g, Radix Clematidis 17g, Caulis Spatholobi 13g presses the processing of medicinal material processing standard and concocts, and dried and crushed becomes coarse powder; Above-mentioned coarse powder with 75% soak with ethanol 48h after, with the speed of per kilogram medical material per minute 4ml percolation slowly, collect percolate, leave standstill 48h, adding water is 45% until concentration of alcohol, filters, and gets filtrate and is added in the absorbent cotton, puts into aluminium foil bag, seals, promptly.
Embodiment 2
The preparation of tincture: get Flos Carthami 23g, Rhizoma Drynariae 21g, Radix Clematidis 17g, Caulis Spatholobi 13g presses the processing of medicinal material processing standard and concocts, and dried and crushed becomes coarse powder, above-mentioned coarse powder with 75% soak with ethanol 48h after, with the speed of per kilogram per minute 5ml percolation slowly, collect percolate, leave standstill 50h, adding water to concentration of alcohol is 50%, filters, and gets the filtrate fill in 30ml high-density plastic bottle closure, add a cover, promptly.
Embodiment 3
The preparation of liniment: get Flos Carthami 22g, Rhizoma Drynariae 20g, Radix Clematidis 17g, Caulis Spatholobi 14g presses the processing of medicinal material processing standard and concocts, and dried and crushed becomes coarse powder, ethanol with 80% refluxes, and collects backflow, and the distilling under reduced pressure backflow also reclaims ethanol, spray drying, promptly get extract powder, get 20g extract powder (being equivalent to the 73g crude drug) and add 70% dimethyl sulphoxide solution 1000ml dissolving, fill is in 30ml high-density plastic bottle closure, add a cover, promptly.Directly put on the skin and be coated with, rub and put on the skin in the affected part.
Embodiment 4
The preparation of ointment: get Flos Carthami 23g, Rhizoma Drynariae 21g, Radix Clematidis 17g, Caulis Spatholobi 13g, medical material is pressed concocted specification processing and is concocted, and dried and crushed becomes coarse powder, refluxes with 75% ethanol, collect backflow, the distilling under reduced pressure backflow also reclaims ethanol, and spray drying promptly gets extract powder, extract powder and an amount of substrate are ground well, promptly.
Embodiment 5
The preparation of emplastrum: get Flos Carthami 25g, Rhizoma Drynariae 22g, Radix Clematidis 16g, Caulis Spatholobi 13g, medical material press concocted specification processing and concoct, and dried and crushed becomes fine powder, and the fine powder beach is being mounted on the backing material, promptly.
Embodiment 6
The preparation of cataplasma: get Flos Carthami 23g, Rhizoma Drynariae 20g, Radix Clematidis 18g, Caulis Spatholobi 13g, medical material press concocted specification processing and concoct, and dried and crushed becomes impalpable powder, with impalpable powder with after water-soluble high-molecular material substrate is mixed, promptly.
Embodiment 7
Stick the preparation of agent: get Flos Carthami 25g, Rhizoma Drynariae 20g, Radix Clematidis 17g, Caulis Spatholobi 14g presses the processing of medicinal material processing standard and concocts, and dried and crushed becomes coarse powder; Above-mentioned coarse powder with 50% soak with ethanol 50h after, with the speed of per kilogram per minute 3ml percolation slowly, collect percolate, filter, get filtrate and be added in the non-woven fabric plate, put into aluminium foil bag, seal, promptly.
Embodiment 8
The preparation of tincture: get Flos Carthami 21g, Rhizoma Drynariae 21g, Radix Clematidis 18g, Caulis Spatholobi 14g, press medicinal material processing standard processing and concoct, dried and crushed becomes coarse powder, above-mentioned coarse powder with 55% soak with ethanol 45h after, with the speed of per kilogram per minute 5ml percolation slowly, collect percolate, filter, get the filtrate fill in 30ml high-density plastic bottle closure, add a cover, promptly.
Comparative Examples 1
Get Flos Carthami 23g, Caulis Spatholobi 13g, Rhizoma Drynariae 21g, Radix Clematidis 17g, Caulis Sargentodoxae 21g, Herba speranskiae tuberculatae 21g, Semen Sinapis Albae 13g, Rhizoma Polygoni Cuspidati 13g press the processing of medicinal material processing standard and concoct, and dried and crushed becomes coarse powder; After soaking 48h in right amount with 75% ethanol, with the speed of per kilogram per minute 4ml percolation slowly, collect percolate, leave standstill 48h, adding water to concentration of alcohol is 45%.Taking liquid is added in the absorbent cotton, puts into aluminium foil bag, seals, promptly.
The analgesic effect of the percolate that Comparative Examples 1 and embodiment 1 make surveys the pain method with photo-thermal and hot plate method compares, and do contrast with 45% ethanol.Select for use and predicting pain threshold on the TF photo-thermal dolorimeter and on 55 ± 0.5 ℃ of hot plates, improving percentage rate with the threshold of pain is the relatively analgesic activity of two embodiment of index, and it is as follows that the result improves percentage rate (%) in the average threshold of pain:
Table 1
| Minute | Embodiment 1 | Comparative Examples 1 |
| After the administration 2 minutes | 83.5 | 65.0 |
| After the administration 10 minutes | 45.3 | 26.3 |
| After the administration 30 minutes | 24.0 | 23.6 |
The analgesic activity of the Chinese medicine preparation that makes with embodiment 1 is better than the medicine that makes with Comparative Examples 1 as known from Table 1.
Claims (10)
1, a kind of Chinese medicine preparation for the treatment of pain is characterized in that: it is to be made by the Chinese medicine of following weight percentage ratio: Flos Carthami 5%～85%, Rhizoma Drynariae 5%～85%, Radix Clematidis 5%～85%, Caulis Spatholobi 5%～85%.
2, the Chinese medicine preparation of treatment pain according to claim 1 is characterized in that: it is to be made by the Chinese medicine of following weight percentage ratio: Flos Carthami 25%～45%, Rhizoma Drynariae 25%～35%, Radix Clematidis 20%～30%, Caulis Spatholobi 10～20%.
3, the Chinese medicine preparation of treatment pain according to claim 2 is characterized in that: described Chinese medicine preparation is made exterior-applied formulation, comprises sticking agent, liniment, tincture, ointment, emplastrum and cataplasma.
4, the preparation method of claim 1 or 2 described Chinese medicine preparation is characterized in that may further comprise the steps:
1. Flos Carthami, Rhizoma Drynariae, Radix Clematidis and Caulis Spatholobi are pressed the processing of medicinal material processing standard and concoct, dried and crushed becomes coarse powder;
2. the coarse powder concentration that 1. step is obtained is to carry out percolation behind soak with ethanol 40～50h of 35%～95%, collects percolate;
3. the with medicament conventional method is mixed with external preparation with the percolate that 2. step obtains.
5, preparation method according to claim 4 is characterized in that: after 2. step comprised also that the percolate that collection is obtained leaves standstill 40～50h, adding water to its concentration of alcohol was 35%～55%.
6, preparation method according to claim 4 is characterized in that: the step 2. speed of middle percolation is per kilogram medical material per minute 3～5ml.
7, according to claim 5 or 6 described preparation methoies, it is characterized in that: the external preparation of step described in 3. is for sticking agent, tincture or liniment.
8, the preparation method of a kind of claim 1 or 2 described Chinese medicine preparation is characterized in that may further comprise the steps:
1. Flos Carthami, Rhizoma Drynariae, Radix Clematidis and Caulis Spatholobi are pressed the processing of medicinal material processing standard and concoct, dried and crushed becomes fine powder or impalpable powder;
2. the with medicament conventional method is mixed with ointment, cataplasma or emplastrum with above-mentioned fine powder, impalpable powder.
9, the preparation method of a kind of claim 1 or 2 described Chinese medicine preparation is characterized in that may further comprise the steps:
1. Flos Carthami, Rhizoma Drynariae, Radix Clematidis and Caulis Spatholobi are pressed the processing of medicinal material processing standard and concoct, dried and crushed becomes coarse powder;
2. the coarse powder concentration that 1. step is obtained is that 70%～95% ethanol refluxes, and collects backflow;
3. the backflow that 2. distilling under reduced pressure step obtains reclaims ethanol, and spray drying gets extract powder;
4. with medicament conventional method extract powder that 3. step is obtained is mixed with liniment, ointment, emplastrum or cataplasma.
10, the application of the described Chinese medicine preparation of one of claim 1 to 3 in the medicine of preparation treatment pain.
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| CNB2006101033544A CN100496544C (en) | 2006-07-21 | 2006-07-21 | Chinese medicine preparation for treating pains and its preparing method and use |
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| CNB2006101033544A CN100496544C (en) | 2006-07-21 | 2006-07-21 | Chinese medicine preparation for treating pains and its preparing method and use |
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| CN100496544C CN100496544C (en) | 2009-06-10 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735671A (en) * | 2013-12-27 | 2014-04-23 | 南宁市品迪生物工程有限公司 | Medicament for treating gout |
| CN107412365A (en) * | 2017-08-09 | 2017-12-01 | 易中岚 | It is a kind of to nurse one's health waist dish outstanding and the production method of medicament and application method of cervical vertebra hyperplasia |
| CN110141622A (en) * | 2018-07-26 | 2019-08-20 | 杭州来米医疗科技有限公司 | A kind of Chinese medicine composition and its preparation method and application for treating pain |
| CN110141621A (en) * | 2018-07-26 | 2019-08-20 | 杭州来米医疗科技有限公司 | A kind of Chinese medicine composition and its preparation method and application for treating pain |
| CN110201037A (en) * | 2019-05-22 | 2019-09-06 | 新疆火焰沙健康科技有限公司 | A kind of Chinese medicine ointment |
| CN110420251A (en) * | 2019-09-17 | 2019-11-08 | 陆载团 | A kind of exterior-applied medical wine and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735671A (en) * | 2013-12-27 | 2014-04-23 | 南宁市品迪生物工程有限公司 | Medicament for treating gout |
| CN103735671B (en) * | 2013-12-27 | 2016-01-27 | 南宁市品迪生物工程有限公司 | A kind of medicine for the treatment of gout |
| CN107412365A (en) * | 2017-08-09 | 2017-12-01 | 易中岚 | It is a kind of to nurse one's health waist dish outstanding and the production method of medicament and application method of cervical vertebra hyperplasia |
| CN110141622A (en) * | 2018-07-26 | 2019-08-20 | 杭州来米医疗科技有限公司 | A kind of Chinese medicine composition and its preparation method and application for treating pain |
| CN110141621A (en) * | 2018-07-26 | 2019-08-20 | 杭州来米医疗科技有限公司 | A kind of Chinese medicine composition and its preparation method and application for treating pain |
| CN110141621B (en) * | 2018-07-26 | 2022-03-11 | 杭州来米医疗科技有限公司 | Traditional Chinese medicine composition for treating pain and preparation method and application thereof |
| CN110141622B (en) * | 2018-07-26 | 2022-03-11 | 杭州来米医疗科技有限公司 | Traditional Chinese medicine composition for treating pain and preparation method and application thereof |
| CN110201037A (en) * | 2019-05-22 | 2019-09-06 | 新疆火焰沙健康科技有限公司 | A kind of Chinese medicine ointment |
| CN110420251A (en) * | 2019-09-17 | 2019-11-08 | 陆载团 | A kind of exterior-applied medical wine and preparation method thereof |
| CN111529587A (en) * | 2020-06-19 | 2020-08-14 | 陈绪春 | Traditional Chinese medicine composition for treating sciatica |
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| Publication number | Publication date |
|---|---|
| CN100496544C (en) | 2009-06-10 |
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