CN106963923A - A kind of Chinese medicine composition and preparation method and application with analgesic activity - Google Patents
A kind of Chinese medicine composition and preparation method and application with analgesic activity Download PDFInfo
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- CN106963923A CN106963923A CN201710339458.3A CN201710339458A CN106963923A CN 106963923 A CN106963923 A CN 106963923A CN 201710339458 A CN201710339458 A CN 201710339458A CN 106963923 A CN106963923 A CN 106963923A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
A kind of Chinese medicine composition and preparation method and application with analgesic activity, it is related to the field of Chinese medicines, solving existing chemicals analgesic has the ill symptomses, the same analgesic drug product of long-term Reusability, the problem of body can produce drug resistance such as lesions of liver and kidney, stomach irritation and allergic reaction.The present invention is in terms of parts by weight, and the Chinese medicine composition includes following components：10~15 parts of Radix Angelicae Sinensis, 10~15 parts of Ligusticum wallichii, 10~15 parts of peach kernel, 10~15 parts of Fructus meliae toosendan, 5~8 parts of corydalis tuber, 5~8 parts of safflower, 5~8 parts of the red sage root, 5~8 parts of Rhizoma Sparganii, 5~8 parts of curcuma zedoary, 2~5 parts of catechu, 2~5 parts of frankincense, 2~5 parts of myrrh, 2~5 parts of dragon's blood, 0.1~1 part of enoxolone, 1~2 part of borneol, 1~5 part of menthol.The selected pure natural herbal medicine of the present invention is made, and the property of medicine is gently complementary, with promoting blood circulation, regulate channels and activate collateral, dispelling wind and eliminating pain, swelling and pain relieving the effects such as, without any excitant, have no side effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation method with analgesic activity
And application.
Background technology
Traditional Chinese medical theory belongs to " pain " one kind of " numbness " card, and numbness disease refers to the positive unsaturated vapor of body, weakened defensive QI,
The perverse trends such as wind, cold, wet, heat are taken advantage of a weak point, and cause qi and blood stagnation, and obstruction of meridians and collaterals causes the general name of related system disease.Patient is more
There is wound, strain or the medical history such as catch cold, focus mostly occurs in Bones and joints junction.Modern medicine believes that, various arthropathies
Change is human muscle and manadesma cause under strain, wound, the factor such as catch cold it is local produce aseptic inflammation, in early days by chemically
The release of many algogenic substances of inflammation, which is stimulated, causes pain, late period muscular fascia adhesion, contracture, mechanical pressure nerve, blood vessel, draws
Play dyshaemia and pain.
The muscles along the regular meridians tissue of normal condition sending down the fishbone periarticular is usually in poised state, maintains the stability of body.When
Most muscle of joint muscle group are chronically at nervous strain state, or the anchor such as bend over one's desk working, persistently bow for a long time,
So as to causing muscle fiber injury, neural blood vessel card is pressed through long, joint week portion's muscle and manadesma be therefore damaged generation aseptic inflammation,
Produce oedema, ooze out, muscle fibre spasm, the pathological change such as denaturation, cause joint manadesma chamber pressure and surface tension to increase, flesh
Meat fascia tissue compensatory hypertrophy is plump, causes the reduction of manadesma intracavitary volume, pressure to be increased, manadesma surface tension increases, nerve
Tip is produced on pain symptom, and sick position very close to muscles along the regular meridians by the compressing of soft tissue abnormality's tension force.If manadesma and muscle, muscle
Between film and hypodermis because damage or inflammation there is adhesion and scarring, or manadesma in itself with sensory nerve adhesion, then
This relative displacement just can stimulate or oppress sensory nerve, so as to cause pain, cardinal symptom is ached for joint week portion, is closed
Saving to all directions activity can be limited, and be become apparent with abduction, upper act, inward turning outward turning, severe patient is felt restless, influence sleep.
Existing analgesic medical technology is wide, for example：Oral relieve the pain medicine, injection anodyne, physiotherapy analgesic, nerve block
Analgesic, liniment analgesic etc..Existing chemicals analgesic is divided into NSAIDs, central anodyne, narcoticness analgesic
Medicine, relieving spasm and pain medicine and antianxiety class anodyne, such medicine typically have lesions of liver and kidney, stomach irritation and allergic reaction etc. no
Good symptom, the same analgesic drug product of long-term Reusability, body can produce drug resistance.
The content of the invention
In order to overcome above-mentioned deficiency, the present invention provides a kind of Chinese medicine composition and preparation method with analgesic activity and should
With can treat arthralgia, reach the purpose treated both principal and secondary aspect of disease.
The present invention is as follows to solve the technical scheme that technical problem is used：
A kind of Chinese medicine composition with analgesic activity that the present invention is provided, in terms of parts by weight, the Chinese medicine composition bag
Containing following components：
It is 10~15 parts of Radix Angelicae Sinensis, 10~15 parts of Ligusticum wallichii, 10~15 parts of peach kernel, 10~15 parts of Fructus meliae toosendan, 5~8 parts of corydalis tuber, red
Spend 5~8 parts, 5~8 parts of the red sage root, 5~8 parts of Rhizoma Sparganii, 5~8 parts of curcuma zedoary, 2~5 parts of catechu, 2~5 parts of frankincense, 2~5 parts of myrrh, blood
Exhaust 2~5 parts, 0.1~1 part of enoxolone, 1~2 part of borneol, 1~5 part of menthol.
As preferred embodiment, a kind of Chinese medicine composition with analgesic activity of the invention in terms of parts by weight, is wrapped
Containing following components：12 parts of Radix Angelicae Sinensis, 12 parts of Ligusticum wallichii, 12 parts of peach kernel, 12 parts of Fructus meliae toosendan, 6 parts of corydalis tuber, 6 parts of safflower, 6 parts of the red sage root, three
6 parts of rib, 6 parts of curcuma zedoary, 4 parts of catechu, 4 parts of frankincense, 4 parts of myrrh, 4 parts of dragon's blood, 0.2 part of enoxolone, 1.3 parts of borneol, menthol
4.5 part.
As preferred embodiment, auxiliary material is also included in a kind of Chinese medicine composition with analgesic activity of the invention, it is auxiliary
It is 15~500 parts to expect consumption.
As preferred embodiment, above-mentioned auxiliary material be selected from rubber, thermoplastic elastomer, rosin, rosin derivative, vaseline,
Lanolin, zinc oxide, Sodium Polyacrylate, carmethose, gelatin, glycerine, superfine silica gel powder, starch, starch derivatives, poly- second
One or more in glycol, 1,2 propane diols, carbomer, NaLS, water.
As preferred embodiment, the one kind or many of above-mentioned auxiliary material in gelatin, starch, glycerine, Sodium Polyacrylate
Kind.
Present invention also offers a kind of above-mentioned preparation method of the Chinese medicine composition with analgesic activity, according to each component weight
Number is measured, by Radix Angelicae Sinensis, Ligusticum wallichii, peach kernel, Fructus meliae toosendan, corydalis tuber, safflower, the red sage root, Rhizoma Sparganii, curcuma zedoary, catechu, frankincense, myrrh, blood
Exhaust, borneol, enoxolone ultramicro grinding into superfine powder, add menthol, patch or emplastrum be prepared into through preparation process.
As preferred embodiment, according to each component parts by weight, Radix Angelicae Sinensis, Ligusticum wallichii, curcuma zedoary, frankincense, myrrh are extracted and waved
Hair oil is standby；Into the gained dregs of a decoction add catechu, peach kernel, Fructus meliae toosendan, corydalis tuber, safflower, the red sage root, Rhizoma Sparganii, using water extract or
Ethanol water is extracted, then obtains thick paste after filtering, concentration；Dragon's blood superfine powder, enoxolone are added into gained thick paste ultra-fine
Powder, borneol fine powder, menthol, auxiliary material, volatile oil, patch or emplastrum are prepared into through preparation process.
As preferred embodiment, in above-mentioned ethanol water, the volume fraction of ethanol is 40%~70%.
Treatment arthralgia medicament is being prepared present invention also offers a kind of above-mentioned Chinese medicine composition with analgesic activity
In application.
The beneficial effects of the invention are as follows：
A kind of selected pure natural herbal medicine of Chinese medicine composition with analgesic activity of the present invention is made, and the property of medicine is gentle, complementary,
Mutually acted synergistically between dialectical composition of prescription, each medicine, with promoting blood circulation, regulate channels and activate collateral, dispelling wind and eliminating pain, detumescence stop
The effects such as pain, ache for traumatic injury, muscles and bones, cervical spondylopathy, the protrasion of the lumbar intervertebral disci, back muscular strain, the periarthritis of shoulderjoint,
Using the preparation method of the present invention patch or patch is made in above-mentioned Chinese medicine composition by the diseases such as tennis elbow, synovitis, determined curative effect
Paste, the patch or emplastrum to skin without any excitant, have no side effect, the purpose treated both principal and secondary aspect of disease can be reached.
Embodiment
A kind of Chinese medicine composition with analgesic activity of the present invention, consisting of Radix Angelicae Sinensis, Ligusticum wallichii, peach kernel, Fructus meliae toosendan, prolonging
Hu Suo, safflower, the red sage root, Rhizoma Sparganii, curcuma zedoary, catechu, frankincense, myrrh, dragon's blood, enoxolone, borneol, menthol, by extract or
Person does not extract the active component in medicinal material, adds proper pharmaceutical excipients, patch or emplastrum are processed into existing preparation process.
The present invention carries out prescription, Radix Angelicae Sinensis and peach kernel according to Traditional Chinese medical theory：Activate blood circulation and disperse blood clots analgesic, Ligusticum wallichii and Fructus meliae toosendan：
Blood-activating and qi-promoting is relieved pain, and Radix Angelicae Sinensis, peach kernel, Ligusticum wallichii, the medicine of Fructus meliae toosendan four are shared, and blood-activating analgetic is altogether monarch drug in a prescription.Safflower and the red sage root：Auxiliary
Monarch drug in a prescription promoting blood circulation is relieved pain, corydalis tuber：Aid in the analgesic of monarch drug in a prescription blood-activating and qi-promoting, Rhizoma Sparganii and curcuma zedoary：Monarch drug in a prescription dissolving stasis promoting qi circulation and relieving pain is aided in,
It is ministerial drug altogether.Frankincense and myrrh：Promoting qi circulation and relieving pain, makes blood circulation depending on qi flow, the stasis of blood go network to lead to, pain is stopped certainly, dragon's blood：Promoting blood circulation and stopping pain, stagnation resolvation
Hemostasis, expelling pus and promoting granulation, catechu：Promoting blood circulation is cured the wound, hemostasia and promoting granulation, altogether will for assistant.Borneol：Clearing away heat to and alleviating pain, anti-corrosion is antipruritic, have one's ideas straightened out, thin
Lotus alcohol：Resuscitation with aromatics, refrigerant antipruritic, two medicines have effect of having one's ideas straightened out, and help Drug Percutaneous Absorption, enoxolone：Antibacterial, anti-inflammatory,
Antiallergy, is to make medicine altogether.In the present invention, all medicines share plays promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain effect altogether.
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Gel rubber plaster ointment preparation one of the embodiment 1 containing Chinese medicine composition of the present invention
Prescription：Radix Angelicae Sinensis 13g, Ligusticum wallichii 13g, peach kernel 11.5g, Fructus meliae toosendan 11g, corydalis tuber 6g, safflower 5.5g, red sage root 5g, three
Rib 5g, curcuma zedoary 5g, catechu 4.5g, frankincense 4g, myrrh 4g, dragon's blood 4g, enoxolone 0.2g, borneol 1.5g, menthol 5g.
Preparation method：Step 1: above-mentioned all tastes are in addition to menthol, micro mist is ground into, Sodium Polyacrylate 30g, gelatin 15g is added and mixes
Close uniform, add water 600ml, 60 DEG C of sealed thermal insulatings 2 hours constantly stir, obtain mixture A.
Step 2: being stirred after starch 200g and glycerine 400g is mixed, 80 DEG C are heated to, mixture B is obtained.
Step 3: menthol 5g is added in mixture A, mix, obtain mixture C.
Step 4: rapid mix B and C, lining overlay film rolling is mated formation, steam shaping, cutting, packaging are produced containing the present invention
The gel emplastrum of Chinese medicine composition.
Gel rubber plaster ointment preparation two of the embodiment 2 containing Chinese medicine composition of the present invention
Prescription：Radix Angelicae Sinensis 12g, Ligusticum wallichii 12g, peach kernel 12g, Fructus meliae toosendan 12g, corydalis tuber 6g, safflower 6g, red sage root 6g, Rhizoma Sparganii 6g,
Curcuma zedoary 6g, catechu 4g, frankincense 4g, myrrh 4g, dragon's blood 4g, enoxolone 0.2g, borneol 1.3g, menthol 4.5g.
Preparation method：Step 1: above-mentioned all tastes are in addition to dragon's blood, borneol, menthol, coarse powder, plus ethanol water (ethanol are ground into
Volume fraction be 50%) refluxing extraction 2 times, 2 hours every time, the mesh screen of extract solution 80, reclaim ethanol to without alcohol taste, concentration
Into thick paste A (1.30~1.35,60 DEG C of relative density).
Step 2: taking dragon's blood 4g, borneol 1.3g, 200 mesh sieves were crushed, Sodium Polyacrylate 30g, gelatin 15g mixing is added
Uniformly, add water 500ml, 60 DEG C of sealed thermal insulatings 2 hours, constantly stirs, and obtains mixture B.
Step 3: being stirred after starch 200g and glycerine 400g is mixed, 80 DEG C are heated to, mixture C is obtained.
Step 4: adding thick paste A, mixture B, menthol 4.5g into mixture C, mix, lining overlay film rolling mats formation,
Steam shaping, cutting, packaging produce the gel emplastrum containing Chinese medicine composition of the present invention.
It is prepared by rubber emplastrum of the embodiment 3 containing Chinese medicine composition of the present invention
Prescription：Radix Angelicae Sinensis 14g, Ligusticum wallichii 12g, peach kernel 11g, Fructus meliae toosendan 10g, corydalis tuber 8g, safflower 5g, red sage root 6g, Rhizoma Sparganii 5g,
Curcuma zedoary 5g, catechu 3g, frankincense 3g, myrrh 3g, dragon's blood 5g, enoxolone 0.2g, borneol 1.6g, menthol 4.8g.
Preparation method：Step 1: above-mentioned all tastes are in addition to dragon's blood, borneol, menthol, coarse powder, plus ethanol water (ethanol are ground into
Volume fraction be 40%) refluxing extraction 2 times, 2 hours every time, the mesh screen of extract solution 80, reclaim ethanol to without alcohol taste, concentration
Into thick paste A (1.30~1.35,60 DEG C of relative density).
Step 2: taking dragon's blood 4g, borneol 1.3g, enoxolone 0.2g, 200 mesh sieves were crushed, mixture B is obtained.
Step 3: taking rubber 500g, clean, in 50 DEG C~60 DEG C dryings, be cut into bulk, being plasticated in rubber mixing machine reticulates
Thin slice, adds thick paste A, and mixture B, menthol 4.8g, zinc oxide 30g, rosin 50g are added after being swelled, and refining pressure is uniform, apply
Cream, cutting, lid lining, packaging produce the rubber emplastrum containing Chinese medicine composition of the present invention.
Patch preparation method one of the embodiment 4 containing Chinese medicine composition of the present invention
Prescription：Radix Angelicae Sinensis 14g, Ligusticum wallichii 12g, peach kernel 11g, Fructus meliae toosendan 10g, corydalis tuber 8g, safflower 5g, red sage root 6g, Rhizoma Sparganii 5g,
Curcuma zedoary 5g, catechu 3g, frankincense 3g, myrrh 3g, dragon's blood 5g, enoxolone 0.2g, borneol 1.6g, menthol 4.8g.
Preparation method：Step 1: above-mentioned all tastes are ground into coarse powder in addition to dragon's blood, borneol, menthol, the refluxing extraction that adds water 2 times,
2 hours every time, the mesh screen of extract solution 80, it is condensed into thick paste A (1.30~1.35,60 DEG C of relative density).
Step 2: taking dragon's blood 4g, borneol 1.3g, enoxolone 0.2g, 200 mesh sieves were crushed, mixture B is obtained.
Step 3: take glycerine 50g, NaLS 150g, heating water bath fusing is uniform, adds lanolin 30g, all
Intellectual circle 60g, heating water bath fusing is uniform, obtains mixture C.
Step 4: add thick paste A, mixture B, menthol 4.8g into mixture C, it is slightly cold after be spread evenly across lid lining
On, it is affixed on after cutting out on pressure sensitive adhesive and produces the patch containing Chinese medicine composition of the present invention.
Patch preparation method two of the embodiment 5 containing Chinese medicine composition of the present invention
Prescription：Radix Angelicae Sinensis 12g, Ligusticum wallichii 12g, peach kernel 12g, Fructus meliae toosendan 12g, corydalis tuber 6g, safflower 6g, red sage root 6g, Rhizoma Sparganii 6g,
Curcuma zedoary 6g, catechu 4g, frankincense 4g, myrrh 4g, dragon's blood 4g, enoxolone 0.2g, borneol 1.3g, menthol 4.5g.
Preparation method：Step 1: above-mentioned all tastes are in addition to dragon's blood, borneol, menthol, coarse powder, plus ethanol water (ethanol are ground into
Volume fraction be 70%) refluxing extraction 2 times, 2 hours every time, the mesh screen of extract solution 80, reclaim ethanol to without alcohol taste, concentration
Into thick paste A (1.30~1.35,60 DEG C of relative density).
Step 2: taking dragon's blood 4g, borneol 1.3g, 200 mesh sieves were crushed, mixture B is obtained.
Step 3: take glycerine 50g, NaLS 150g, heating water bath fusing is uniform, adds lanolin 30g, all
Intellectual circle 60g, heating water bath fusing is uniform, obtains mixture C.
Step 4: add thick paste A, mixture B, menthol 4.5g into mixture C, it is slightly cold after be spread evenly across lid lining
On, it is affixed on after cutting out on pressure sensitive adhesive and produces the patch containing Chinese medicine composition of the present invention.
The acute skin irritation of embodiment 6 is tested
Experimental animal white rabbit, male and female, it is 2kg or so white rabbit 4 to choose body weight, and single cage is raised, will before experiment
Experimental animal is placed on the 3 day time of adaptation in experimental animal room.About 24h before experiment, experimental animal back backbone diamond wool is cut,
Epidermis, the left and right each about 5cm × 5cm of unhairing scope can not be damaged.The patch of tested material (the gained sample of embodiment 3) one is taken to be placed directly against
On the backbone skin side of experimental animal back, then covered with two layers of gauze (5cm × 5cm) and one layer of glassine paper, then with stingless
Swash property adhesive plaster and bandage is fixed.Experimental animal back backbone skin opposite side does not make any processing, is used as control.Using envelope
Experiment is closed, the time is 24h.With warm water or nonirritant solvent cleaning residual tested material after off-test.
1h, 24h, 48h and 72h observation dermoreaction after tested material are removed, is that standard progress dermoreaction is commented with table 1
Point, overall merit is carried out with the average value that experimental animal is integrated, time point top average is respectively observed according to 24h, 48h and 72h,
With table 2 for standard determination skin irritatin intensity, acute skin irritation result of the test is shown in Table 3.
The skin wound repair of table 1 scores
The skin irritatin strength grading of table 2
| Integral mean value | Strength grading |
| 0~﹤ 0.5 | It is nonirritant |
| 0.5~﹤ 2.0 | Slight stimulation |
| 2.0~﹤ 6.0 | Medium excitant |
| 6.0~﹤ 8.0 | Strong and stimulating |
The acute skin irritation result of the test of table 3
Test Summary：It is very limited that the driven beyond the region of objective existence of acute skin irritation test result shifts human reriability onto.White rabbit exists
It is in most cases sensitive compared with the mankind to irritant or corrosive material, therefore Acute irritation test is carried out using white rabbit
Experiment has certain science reason, and rubber emplastrum of the experiment results proved containing Chinese medicine composition of the present invention is almost without excitant.
The clinical typical case of embodiment 7
Case 1：Patient's tension force army, man, 46 years old when being examined over 2016, people from Changchun
Patient examined on March 4th, 2016.Main suit：Right ankle swelling, pain, difficulty in walking three days.Present illness history：Three
Its cause is walked careless right sprain of ankle joint, occurs spraining position swelling, pain, traumatic flexion-extension dysfunction, difficulty in walking, reposes three
After it still swelling, pain and to examine.Have a medical check-up：Swelling, subcutaneous hemorrhage, limitation of activity, local tenderness on the outside of right ankle.The right ankle of X-ray is just
Lateral radiograph finding：Joint position is normal, have no fracture.Diagnosis：Right ankle soft tissue injury.Treatment：Stickers, which is applied, contains Chinese medicine of the present invention
The gel emplastrum of composition, a daily patch, Stickers is applied three days.After three days, carry out institute's check, swelling is eliminated, without obvious tenderness, walking is tired
Difficult symptom is obviously improved, but is slightly ached.After advising Qi Zai Stickers deposited three days, through follow-up, patient pain, swelling symptom are completely eliminated,
Walking is freely.
Case 2：Patient Ren Xuebin, man, 55 years old, people from Changchun
Patient examined on March 18th, 2016.Main suit：Knee joint swelling, pain, difficulty in walking nine days.Present illness history：Nine days
There is left side gonalgia, bends and stretches limited in cause after climbing the mountain on foot, pain is aggravated when walking and squatting down, and the knee joint that comes out gradually swells
It is swollen and to examine.Have a medical check-up：Left side knee joint flexion-extension motion is limited, and is squatted down difficult and with pain, periarticular can have limitation pressure
Ache point, floating patella test is positive.MRI (magnetic resonance imaging) is shown in：Arthroedema, cartilage is without exception.Diagnosis：Left knee joint synovial membrane
It is scorching.Treatment：Stickers applies the patch containing Chinese medicine composition of the present invention, and daily Tie , Stickers are applied seven days.After seven days, come institute and check, pain,
Swelling mitigates, and continues symptom after above-mentioned treatment ten days and disappears, activity is freely.
Case 3：Patient Wang Jie, female, 37 years old, people from Changchun
Patient examined on April 7th, 2016.Main suit：Neck-shoulder pain is more than January.Present illness history：One month cause is for a long time
Bend over one's desk working, neck-shoulder pain, neck limitation of activity, and existing right scapular region pain occur, often because dizzy, evil occurs in position chanP
The symptoms such as the heart, although nearly one month of oral JINGTONGLING JIAONANG, but symptom is not improved.MRI (magnetic resonance imaging) is shown in：C3~
C4, C5~C6 disks are protruded.Diagnosis：Herniation of cervical disc.Treatment：Stickers applies the rubber emplastrum containing Chinese medicine composition of the present invention,
Tip of the day , Stickers are applied five days.After five days, carry out institute's check, above-mentioned symptom mitigates, and Ji Xu Stickers are applied five days, and the symptom such as pain, dizziness disappears
Lose, cervical vertebra moving is freely.
The invention discloses a kind of Chinese medicine composition with analgesic activity, those skilled in the art can be used for reference in herein
Hold, be suitably modified technological parameter realization.In particular, all similar replacements and change are to those skilled in the art
For be it will be apparent that they are considered as being included in the present invention.The product of the present invention is carried out by preferred embodiment
Description, related personnel can substantially not depart from present invention, product as described herein is being modified in spirit and scope
Or suitably change with combining, to realize and apply the technology of the present invention.
Claims (9)
1. a kind of Chinese medicine composition with analgesic activity, it is characterised in that in terms of parts by weight, the Chinese medicine composition include with
Lower component：
10~15 parts of Radix Angelicae Sinensis, 10~15 parts of Ligusticum wallichii, 10~15 parts of peach kernel, 10~15 parts of Fructus meliae toosendan, 5~8 parts of corydalis tuber, safflower 5
~8 parts, 5~8 parts of the red sage root, 5~8 parts of Rhizoma Sparganii, 5~8 parts of curcuma zedoary, 2~5 parts of catechu, 2~5 parts of frankincense, 2~5 parts of myrrh, dragon's blood 2
~5 parts, 0.1~1 part of enoxolone, 1~2 part of borneol, 1~5 part of menthol.
2. a kind of Chinese medicine composition with analgesic activity according to claim 1, it is characterised in that with parts by weight
Meter, the Chinese medicine composition includes following components：12 parts of Radix Angelicae Sinensis, 12 parts of Ligusticum wallichii, 12 parts of peach kernel, 12 parts of Fructus meliae toosendan, 6 parts of corydalis tuber,
6 parts of safflower, 6 parts of the red sage root, 6 parts of Rhizoma Sparganii, 6 parts of curcuma zedoary, 4 parts of catechu, 4 parts of frankincense, 4 parts of myrrh, 4 parts of dragon's blood, enoxolone 0.2
Part, 1.3 parts of borneol, 4.5 parts of menthol.
3. a kind of Chinese medicine composition with analgesic activity according to claim 2, it is characterised in that also including auxiliary material,
Supplementary product consumption is 15~500 parts.
4. a kind of Chinese medicine composition with analgesic activity according to claim 3, it is characterised in that the auxiliary material is selected from
Rubber, thermoplastic elastomer, rosin, rosin derivative, vaseline, lanolin, zinc oxide, Sodium Polyacrylate, carmethose,
Gelatin, glycerine, superfine silica gel powder, starch, starch derivatives, polyethylene glycol, 1,2 propane diols, carbomer, NaLS, water
In one or more.
5. a kind of Chinese medicine composition with analgesic activity according to claim 4, it is characterised in that the auxiliary material is selected from
One or more in gelatin, starch, glycerine, Sodium Polyacrylate.
6. preparing a kind of method of Chinese medicine composition with analgesic activity in claim 1-5 described in any one, it is special
Levy and be, according to each component parts by weight, by Radix Angelicae Sinensis, Ligusticum wallichii, peach kernel, Fructus meliae toosendan, corydalis tuber, safflower, the red sage root, Rhizoma Sparganii, curcuma zedoary,
Catechu, frankincense, myrrh, dragon's blood, borneol, enoxolone ultramicro grinding add menthol, are prepared into through preparation process into superfine powder
Patch or emplastrum.
7. preparing a kind of method of Chinese medicine composition with analgesic activity in claim 1-5 described in any one, it is special
Levy and be, it is according to each component parts by weight, Radix Angelicae Sinensis, Ligusticum wallichii, curcuma zedoary, frankincense, myrrh extraction volatile oil is standby；To the gained dregs of a decoction
Middle addition catechu, peach kernel, Fructus meliae toosendan, corydalis tuber, safflower, the red sage root, Rhizoma Sparganii, are extracted using water or ethanol water is extracted, then are passed through
Thick paste is obtained after filtering, concentration；Dragon's blood, enoxolone, borneol, menthol, auxiliary material, volatile oil are added into gained thick paste, through system
Agent technique is prepared into patch or emplastrum.
8. a kind of preparation method of Chinese medicine composition with analgesic activity according to claim 7, it is characterised in that institute
State in ethanol water, the volume fraction of ethanol is 40%~70%.
9. a kind of Chinese medicine composition with analgesic activity in claim 1-5 described in any one is preparing treatment arthritis
Application in pain medicament.
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| CN113456786A (en) * | 2021-08-23 | 2021-10-01 | 威海德尚医中医药科技有限公司 | Traditional Chinese medicine formula with effects of promoting blood circulation and removing blood stasis and preparation method thereof |
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Application publication date: 20170721 |