CN1117582C - medicine for treating rheumatoid arthritis and preparing process thereof - Google Patents
medicine for treating rheumatoid arthritis and preparing process thereof Download PDFInfo
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- CN1117582C CN1117582C CN 99103317 CN99103317A CN1117582C CN 1117582 C CN1117582 C CN 1117582C CN 99103317 CN99103317 CN 99103317 CN 99103317 A CN99103317 A CN 99103317A CN 1117582 C CN1117582 C CN 1117582C
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Abstract
The present invention discloses new medicine for treating rheumatoid arthritis, which is mainly used for treating rheumatoid arthritis. The present invention is pure Chinese medicine preparation which is proportionally prepared by using atractylodes rhizomes, large-leaf gentian roots, notopterygium roots, safflower, Chinese angelica, chuanxiong rhizomes, radix dipsaci from Sichuan of China, cyathula roots, nutagrass flatsedge rhizomes, pubescent angelica roots, cassia twigs, clematis roots and pawpaws as raw materials; the medicine is produced into various medicament forms after treatment according to different properties of the medicine, such as capsules, mixture, etc. The present invention has unique formula and making method, treats both manifestation and root cause of disease and has conspicuous curative effect.
Description
The present invention relates to a kind of medicine for the treatment of rheumatoid arthritis, specifically a kind of medicament of the treatment rheumatoid arthritis made from herbal raw material the invention still further relates to the preparation method of this medicine.
Rheumatoid arthritis is the high common disease of a kind of sickness rate, and the misery of bringing for patient's body and mind is very big, the physical and mental health that is seriously endangering the people.Adopt hormones or non-hormone Drug therapys such as indole, antiinflammatory are painful, ibuprofen at present clinically for this type of disease, if this two classes drug main is by suppressing to reach synthesizing of prostaglandin therapeutic effect on different links more.Prostaglandin is both advantageous and disadvantageous to human body, and it can cause inflammation on the one hand, and sclerotin albumen synthesizes the existence that grade all needs prostaglandin in the body on the other hand.Suppress prostaglandin and can make the clinical symptoms of rheumatoid arthritis controlled, but bone lesion still continuing, even quickening bone lesion.Learn in the tcm clinical practice research in recent years,,, cause the gastrointestinal untoward reaction if life-time service can obviously make bone density increase and present the bland necrosis trend though hormone medicine treatment rheumatoid arthritis can obtain respite.
The object of the present invention is to provide a kind of medicine for the treatment of rheumatoid arthritis, patient's whole body is played the effect of dispelling wind and removing obstruction in the collateral, dispelling cold and removing dampness, activating blood circulation to dissipate blood stasis, promoting the flow of QI in the collateral by warming the meridian, reducing swelling and alleviating pain, it is proteic synthetic not influence the interior sclerotin of body, can eliminate its various symptoms quickly, and can make indexs such as RF (rheumatoid factor), ESR (erythrocyte sedimentation rate value) and anti-hemolysis streptostacin 0 recover normal, reach the effect of effecting a permanent cure.Instant effect, curative effect height, toxic and side effects are low, and are difficult for recurrence.
Another object of the present invention provides the preparation method of this rheumatoid arthritis therapeutic agent.
Solution of the present invention is based on the understanding of motherland's medical science to the mechanism of rheumatoid arthritis, filters out the natural drug of dispelling wind and removing obstruction in the collateral, dispelling cold and removing dampness, activating blood circulation to dissipate blood stasis, promoting the flow of QI in the collateral by warming the meridian, reducing swelling and alleviating pain and make compound preparation from motherland medicine treasure-house.Each medicine synergism of distinguishing the flavor of is to reach curative effect.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Rhizoma Atractylodis 26-37 Radix Gentianae Macrophyllae 20-30 Rhizoma Et Radix Notopterygii 21-29
Flos Carthami 4-15 Radix Angelicae Sinensis 13-28 Rhizoma Chuanxiong 13-28
Radix Dipsaci 20-31 Radix Cyathulae 22-30 Rhizoma Cyperi 10-21
Radix Angelicae Pubescentis 19-27 Ramulus Cinnamomi 26-45 Radix Clematidis 15-30
Fructus Chaenomelis 15-25
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Rhizoma Atractylodis 35 Radix Gentianae Macrophyllae 25 Rhizoma Et Radix Notopterygiis 25
Flos Carthami 8 Radix Angelicae Sinensis 20 Rhizoma Chuanxiongs 20
Radix Dipsaci 25 Radix Cyathulaes 25 Rhizoma Cyperis 15
Radix Angelicae Pubescentis 25 Ramulus Cinnamomi 40 Radix Clematidis 20
Fructus Chaenomelis 15
Main component Radix Angelicae Sinensis, Rhizoma Atractylodis, Radix Gentianae Macrophyllae, Radix Dipsaci, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Radix Cyathulae and Ramulus Cinnamomi etc. in the medicine of the present invention mainly contain stronger antiinflammatory, cold expelling and immunosuppressive action.Antiinflammatory action is to realize by the permeability that lowers blood capillary.The capillary permeability that inhibition or antagonism inflammatory mediator suppress due to the histamine increases.Inflammation-inhibiting soaks into and oozes out, and anticoagulant, embolism resistance is arranged and reduce tissue injury's effect.Other effects of respectively distinguishing the flavor of medicine are to increase curative effect, play the effect of activating blood circulation to dissipate blood stasis, reducing swelling and alleviating pain.
Medicine of the present invention can be made various dosage forms according to a conventional method.Wherein preferred capsule and mixture.
For showing medicine of the present invention, systematically selected the rheumatoid arthritis case of all ages and classes, sex and the different courses of disease to the treatment of rheumatoid arthritis effect.At first check patient's erythrocyte sedimentation rate, rheumatoid factor when receipts are examined, the erythrocyte sedimentation rate male of period of disease is 60-130 per hour, and the women is 45-110 per hour, and rheumatoid factor is positive can be defined as rheumatoid arthritis.If the check result of erythrocyte sedimentation rate, rheumatoid factor is not obvious, can't make a definite diagnosis, just continue to check antistreptolysin O that result person between 560-800U also can be diagnosed as rheumatoid arthritis.Concrete symptom is a migration pain, and painful place is indefinite; Arthralgia due to cold is with heavy difficult act of sharp ache, and painful place does not move and fixes; Arthralgia chiefly caused by damp pathogen is lifted or numbness so that vague aching of limbs is difficult.Use medicine of the present invention to treat, be 45 days a course of treatment.
Instructions of taking: can take capsule or mixture.
Take capsule, 2 times on the one, each 6 (every 4 gram), sooner or later
One after each meal;
Take mixture, 3 times on the one, each 15 milliliters, one after each meal.
Its therapeutic effect can be referring to table 1 and table 2 clinical data statistics.Treatment cycle is a course of treatment.
Cure: symptom all disappears, and the erythrocyte sedimentation rate value reaches normal value (male is per hour 20, and the women is per hour 15), and rheumatoid factor RF is negative, and antistreptolysin O reaches normal value 400U;
Effectively: symptom disappears substantially, and joint movement function recovers substantially, and erythrocyte sedimentation rate value male is 20-55 per hour, and the women is 15-30, and rheumatoid factor negative, antistreptolysin O are 400-560U.
Invalid: symptom and sign and assay do not have obvious improvement.
The different course of disease clinical data statistics of table 1
| The course of disease (year) | Case load (people) | Cure | Effectively | Invalid |
| 2-5 | 36 | 31 | 5 | 0 |
| 6-13 | 22 | 20 | 2 | 0 |
| 14-25 | 42 | 19 | 22 | 1 |
| Effective percentage 70% 29% 1% | ||||
Table 2 all ages and classes clinical data statistics
| Age (year) | Case load (people) | Cure | Effectively | Invalid |
| 18-31 | 26 | 17 | 9 | 0 |
| 32-40 | 31 | 20 | 11 | 0 |
| 41-50 | 43 | 23 | 19 | 1 |
| Effective percentage 60% 39% 1% | ||||
By above-mentioned clinical data as seen, the symptom of rheumatoid arthritis can be eliminated and alleviate to medicine treating both the principal and secondary aspects of a disease of the present invention quickly, and the pain phenomenon is disappeared, and dredge the meridian passage makes that erythrocyte sedimentation rate numerical value is most of to recover normal.Therapeutic effect has stability, certainty.Taking convenience, patient easily accepts, and side effect is little, and expense is low.
Embodiment
Take by weighing raw material (gram) by following proportioning:
Rhizoma Atractylodis 35 Radix Gentianae Macrophyllae 25 Rhizoma Et Radix Notopterygiis 25
Flos Carthami 8 Radix Angelicae Sinensis 20 Rhizoma Chuanxiongs 20
Radix Dipsaci 25 Radix Cyathulaes 25 Rhizoma Cyperis 15
Radix Angelicae Pubescentis 25 Ramulus Cinnamomi 40 Radix Clematidis 20
Fructus Chaenomelis 15
Capsule preparation method thereof:
The above-mentioned medicine of respectively distinguishing the flavor of is mixed the back pulverize, cross 1000 mesh sieves, packing is adorned 4 grams for every.
The mixture preparation method:
Add 2500 milliliters in water after the above-mentioned medicine of respectively distinguishing the flavor of mixed, soak decoct after 20 minutes medicinal liquid
1000 milliliters, in medicinal liquid, add 250 gram crystal sugar dissolvings after, treat the medicinal liquid cold after, add
1000 milliliters of 48 ° of Chinese liquor, packing gets final product behind the mixing.
Model case:
1. Tian Hexin, man, 40 years old, people from Xunxian, Henan Province.Suffered from knee joint painful 3 years, and after other hospitalizes have the reconstructed image of adding one month, chemically examined the erythrocyte sedimentation rate value in April, 1997 and be per hour 110, rheumatoid factor is positive, and antistreptolysin O is 600U, and symptom is for removing meridians, the passages through which vital energy circulates functional disorder is diagnosed as rheumatoid arthritis.Take medicament capsule of the present invention, every day 2 times, sooner or later respectively once, and each 5 (every 4 gram), the cycle of taking is a course of treatment.Check transference cure in January, 1998, the erythrocyte sedimentation rate value is per hour 20, and rheumatoid factor is negative, and antistreptolysin O is reduced to 400U, and every index is normal.
2. Liu is long rich, man, 50 years old, the Jun Xianwangzhuan of Henan Province township Liu Gu people from village.It is painful to suffer from right knee joint, and the erythrocyte sedimentation rate value is undesired, and rheumatoid factor is positive, is diagnosed as rheumatoid arthritis.Rose on April 4th, 1998 take 2000 milliliters of drug mixtures of the present invention after, the arthralgia symptom disappears, the erythrocyte sedimentation rate value reaches normal value, rheumatoid factor transfers feminine gender to.During in JIUYUE, 1998 check, the state of an illness is cured, and does not see recurrence.
Claims (8)
1. medicine for the treatment of rheumatoid arthritis is characterized in that it is the medicament of being made by the following weight proportion raw material:
Rhizoma Atractylodis 26-37 Radix Gentianae Macrophyllae 20-30 Rhizoma Et Radix Notopterygii 21-29
Flos Carthami 4-15 Radix Angelicae Sinensis 13-28 Rhizoma Chuanxiong 13-28
Radix Dipsaci 20-31 Radix Cyathulae 22-30 Rhizoma Cyperi 10-21
Radix Angelicae Pubescentis 19-27 Ramulus Cinnamomi 26-45 Radix Clematidis 15-30
Fructus Chaenomelis 15-25
2. the medicine of treatment rheumatoid arthritis according to claim 1, wherein the weight proportion of each raw material is:
Rhizoma Atractylodis 35 Radix Gentianae Macrophyllae 25 Rhizoma Et Radix Notopterygiis 25
Flos Carthami 8 Radix Angelicae Sinensis 20 Rhizoma Chuanxiongs 20
Radix Dipsaci 25 Radix Cyathulaes 25 Rhizoma Cyperis 15
Radix Angelicae Pubescentis 25 Ramulus Cinnamomi 40 Radix Clematidis 20
Fructus Chaenomelis 15
3. the medicine of treatment rheumatoid arthritis according to claim 1 and 2 is characterized in that said medicament is a said dosage form on any pharmaceutics.
4. the medicine of treatment rheumatoid arthritis disease according to claim 3 is characterized in that said medicament is a capsule.
5. the preparation method of the medicine of treatment rheumatoid arthritis according to claim 4, the weight that it is characterized in that said capsule are 4 grams.
6. the medicine of treatment rheumatoid arthritis disease according to claim 3 is characterized in that said medicament is a mixture.
7. the preparation method of treatment rheumatoid arthritis medicine according to claim 6, it is characterized in that: take by weighing the medicine of respectively distinguishing the flavor of (unit is gram) by the described weight proportion of claim 2, decoct with water after the mixing filter 1000 milliliters of decocting liquids, add 250 gram crystal sugar dissolving backs cool after, add packing behind 1000 milliliters of Chinese liquor mixings.
8. the preparation method of treatment rheumatoid arthritis medicine according to claim 7 is characterized in that the number of degrees of the Chinese liquor that added are 48 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99103317 CN1117582C (en) | 1999-03-16 | 1999-03-16 | medicine for treating rheumatoid arthritis and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99103317 CN1117582C (en) | 1999-03-16 | 1999-03-16 | medicine for treating rheumatoid arthritis and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1266704A CN1266704A (en) | 2000-09-20 |
| CN1117582C true CN1117582C (en) | 2003-08-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99103317 Expired - Fee Related CN1117582C (en) | 1999-03-16 | 1999-03-16 | medicine for treating rheumatoid arthritis and preparing process thereof |
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| Country | Link |
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| CN (1) | CN1117582C (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100355450C (en) * | 2005-05-24 | 2007-12-19 | 赵东科 | Qinchuan Tongbi tablet |
| CN101947276A (en) * | 2010-09-04 | 2011-01-19 | 王福山 | Chinese medicinal composition for treating rheumatic arthritis |
| CN102920878A (en) * | 2012-11-15 | 2013-02-13 | 郑军辉 | Traditional Chinese medicine (TCM) medicated wine used for curing rheumatism and rheumatoid arthritis and preparation method of TCM medicated wine |
| CN104056216A (en) * | 2014-06-04 | 2014-09-24 | 范健身 | Formula and preparation method of moxibustion liquid |
| CN104126954A (en) * | 2014-08-04 | 2014-11-05 | 李玉成 | Health care kneepad and manufacturing method thereof |
| CN104491479A (en) * | 2014-09-14 | 2015-04-08 | 王洪润 | Medicinal liquor for treating arthritis and back and leg pain |
| CN105030964A (en) * | 2015-01-26 | 2015-11-11 | 彭田甜 | Formula of anti-rheumatic plaster and producing method thereof |
| CN108815373A (en) * | 2018-07-18 | 2018-11-16 | 陈琼 | A kind of Chinese herbal medicine relaxing tendons and activating collaterals essential oil and preparation method thereof |
| CN109260400A (en) * | 2018-11-19 | 2019-01-25 | 王刚 | It is a kind of for treating the Chinese medicine composition of rheumatism class osteopathy |
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1999
- 1999-03-16 CN CN 99103317 patent/CN1117582C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1266704A (en) | 2000-09-20 |
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