CN103520680A

CN103520680A - Traditional Chinese medicine for treating acute heart failure

Info

Publication number: CN103520680A
Application number: CN201310480290.XA
Authority: CN
Inventors: 姜浩; 于建林
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-09-29
Filing date: 2013-09-29
Publication date: 2014-01-22
Anticipated expiration: 2033-09-29
Also published as: CN103520680B

Abstract

The invention relates to the field of Chinese traditional medicine formulas and in particular relates to a traditional Chinese medicine for treating acute heart failure. The traditional Chinese medicine is characterized by consisting of the following raw material medicines in percent by weight: 12-16% of red flower, 9-12% of angelica sinensis, 6-9% of lumbricus, 5-9% of grifola, 9-13% of apocynum venetum, 6-9% of false hellebore, 3-6% of radix curcumae, 5-7% of rhizoma zingiberis, 5-7% of cortex moutan, 3-5% of folia perillae acutae, 3-6% of Chinese pulsatilla roots, 3-6% of morinda officinalis, 3-6% of radix asteris, 2-5% of radix ophiopogonis, 2-4% of tarragon and 3-5% of lLigusticum wallichii. A preparation method of the traditional Chinese medicine comprises the following steps: adding water into the 16 raw material medicines, soaking, decocting and removing slag so as to obtain a filtering solution. The traditional Chinese medicine for treating the acute heart failure has the beneficial effects of low cost, high curative effect on the treatment of the acute heart failure and no toxic and side effect.

Description

The Chinese medicine for the treatment of acute heart failure

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine that is used for the treatment of acute heart failure.

Background technology

As everyone knows, acute heart failure (heart failure) is the most common with acute left heart failure clinically, and acute right heart failure is more rare.Acute left heart failure refers to acute attack or the myocardial contraction of the left heart function caused by abnormal that increases the weight of obviously reduces, cardiac load increases the weight of, cause that acute cardiac output rapid drawdown, pressure of pulmonary circulation raise suddenly, peripheral resistance increases, cause that pulmonary circulation is congested and occur acute pulmonary venous pleonaemia, pulmonary edema and can accompany the clinical syndrome of histoorgan hypoperfusion and cardiogenic shock.Acute right heart failure refers to that some reason sharply declines myocardium of right ventricle contractility or the front and back load of right ventricle increases the weight of suddenly, thereby causes the clinical syndrome that right cardiac output sharply lowers.Acute heart failure suddenly onset or on original chronic heart failure basis acute exacerbation, great majority show as contractility heart failure, also can show as diastolic heart failure; Premorbid patient majority is associated with organic cardiovascular disease.For the acute heart failure occurring on chronic heart failure basis, stable disease after treatment, should not be called acute heart failure again.The treatment of acute heart failure depends on the treatments such as Folium Digitalis Purpureae, diuretic, vasodilation for many years always, and because its sickness rate, mortality rate are higher, complication is many, again easily repeatedly.And common with middle-aged and elderly people, low because of its each organ function, for conventional medicine, more easily produce toleration or toxic reaction.

Summary of the invention

Object of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, and a kind of Chinese medicine for the treatment of acute heart failure is provided, and cost is low, and the curative effect for the treatment of acute heart failure is high, has no side effect.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of acute heart failure, it is characterized in that: crude drug composition is by weight percentage, Flos Carthami 12～16%, Radix Angelicae Sinensis 9～12%, Pheretima 6～9%, Polyporus 5～9%, Herba Apocyni veneti 9～13%, Herba Adonidis 6～9%, Radix Curcumae 3～6%, Rhizoma Zingiberis 5～7%, Cortex Moutan 5～7%, Folium Perillae 3～5%, the Radix Pulsatillae 3～6%, Radix Morindae Officinalis 3～6%, Radix Asteris 3～6%, Radix Ophiopogonis 2～5%, Artemisia anethoicles Mattf 2～4%, Rhizoma Chuanxiong 3～5%, above-mentioned 16 taste crude drug are soaked, the filtrate of removing slag after decocting to obtain.

The invention has the beneficial effects as follows, cost is low, and treatment acute heart failure curative effect is high, has no side effect.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Adopting Flos Carthami, Radix Angelicae Sinensis, Pheretima, Polyporus, Herba Apocyni veneti, Herba Adonidis, Radix Curcumae, Rhizoma Zingiberis, Cortex Moutan, Folium Perillae, the Radix Pulsatillae, Radix Morindae Officinalis, Radix Asteris, Radix Ophiopogonis, Artemisia anethoicles Mattf, Rhizoma Chuanxiong is that crude drug is prepared from.Every pair of its component (% by weight) is Flos Carthami 13.7, Radix Angelicae Sinensis 10.3, Pheretima 8.2, Polyporus 8.1, Herba Apocyni veneti 10.3, Herba Adonidis 8.2, Radix Curcumae 4.1, Rhizoma Zingiberis 6.3, Cortex Moutan 6.2, Folium Perillae 4.1, the Radix Pulsatillae 3.9, Radix Morindae Officinalis 4.1, Radix Asteris 3.9, Radix Ophiopogonis 3.4, Artemisia anethoicles Mattf 2.1, Rhizoma Chuanxiong 3.1.Getting above-mentioned 16 taste raw material gross weights is 146 grams, adds water to 900～1000ml, and water covers powder, soak 2～3 hours, effective ingredient is easy to fried, then boil with high heat again and slowly decoct about 40 minutes with slow fire, remove slag and to obtain about filtrate 150ml, medicinal residues add water 200～300ml again, decoct 15～20 minutes, and filtrate 50～70ml removes slag to obtain, be total to obtain 200～220ml left and right medicinal liquid, the Chinese medicine decoction that makes treatment acute heart failure, packs in aseptic vial, and seal bottle cap is standby.Every day potion divide 2 times oral, each (medicine) being taken before meal 100～110ml.

Flos Carthami energy promoting blood circulation to restore menstrual flow of the present invention, blood stasis removing pain relieving.Can be as promoting blood circulation to restore menstrual flow medicine.Blood circulation promoting competent silt, promoting the circulation of QI pain relieving.Nourish blood, invigorate blood circulation; Radix Angelicae Sinensis can be enriched blood and be invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; Pheretima salty in the mouth cold in nature.Its salty in the mouth, cold in nature.Function is heat clearing away, spasmolytic, Zhichuan, diuresis.Cure mainly high fanatical hot-tempered, convulsion with spasms, headache conjunctival congestion, the diseases such as expectorant heat, apoplexy, hemiplegia of panting; Polyporus sweet in the mouth, light, flat, return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen.Control dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia, immunological enhancement; Herba Apocyni veneti relieves inflammation or internal heat, blood pressure lowering, heart tonifying, diuresis.Control heart disease, hypertension, neurasthenia, hepatitis abdominal distention, nephritis edema; Herba Adonidis tranquilizing by nourishing the heart, purging liver-fire.Heart tonifying, diuresis.Control cardiopalmus, edema, enters the heart, liver, kidney three warps; Radix Curcumae is pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine; The effects such as Rhizoma Zingiberis has antiulcer, suppresses intestinal tube contraction, function of gallbladder promoting, anti-hypoxia, antithrombotic and antiplatelet aggregation, tell in town, analgesic, analgesia, antiinflammatory, antibiotic, the spiral shell that goes out, schistosomicide; Cortex Moutan cold nature, bitter in the mouth is pungent, nontoxic.Enter the heart, liver, kidney channel.Have and purify the blood, the function of promoting blood circulation to remove blood stasis.Cure mainly macule and spit blood, amenorrhea due to stagnation of blood, premenstrual gesture, carbuncle sore tumefacting virus, traumatic blood stasis, the deficiency of YIN is sent out gesture, lossless; Folium Perillae has the function of the cold expelling that induces sweat, relieving QI stagnancy in the stomach, cures mainly anemofrigid cold, cough, distension and fullness of the chest and abdomen, the diseases such as nausea and vomiting.Seed also claims Fructus Perillae, has the function of antitussive and antiasthmatic, society's expectorant; The Radix Pulsatillae has heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, and the effect of removing dampness and killing parasites, cures mainly pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer; Radix Morindae Officinalis reinforcing the kidney and supporting YANG, bone and muscle strengthening, expelling wind and removing dampness.Cure mainly: suffer from a deficiency of the kidney, few abdomen cold type of pain, incontinence of urine, cold womb, anemofrigid-damp arthralgia, soreness of the waist and knees, rheumatism limb gas; Radix Asteris nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Main cough, deficiency of the lung chronic cough, consumptive lung disease lung abscess, coughs vomiting bloody pus, dysuria.For abundant expectoration, breath with cough, new chronic cough is coughed, chronic cough hemoptysis; Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease cough, Tianjin wound is thirsty; Artemisia anethoicles Mattf clearing away heat-damp and promoting diuresis, jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus etc., pharmaceutical research has function of gallbladder promoting, and liver function protecting is analgesic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating; Rhizoma Chuanxiong activating QI to alleviate the depression, promoting blood circulation and stopping pain.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour.The ingenious prescription of 16 taste Chinese herbal medicine, science compatibility: mutual reinforcement between, the mutual-assistance can be played synergism, can improve drug effect; Mutual restraint between two drugs, the mutual-detoxication can alleviate or eliminate toxic and side effects, the mutual coordinative role of medicine, the specially good effect of playing altogether " acute heart failure ".

The embodiment that each raw material of the present invention also can the listed ratio of according to the form below (percentage by weight) mixes realizes, and its processing method is identical with embodiment mono-.

The clinical trial of carrying out below in conjunction with Wendeng City, Wo Yuan，Ji In Shandong Weihai central hospital is done further, is described in detail the present invention:

1, case selection

With reference to " acute heart failure diagnosis and treatment guide 2005 " diagnostic criteria, conformance with standard person is selected.

2, Therapeutic Method

1 dose minute every day 2 times is oral, and each (medicine) being taken before meal 100～110ml, treats two months altogether.

3, matched group adopts doctor trained in Western medicine conventional therapy: oxygen uptake, calmness, conventional therapy and the symptomatic treatments such as nitroglycerin, angiotensin-convertion enzyme inhibitor (ACEI), cardiotonic glycoside, diuretic; Treatment group, on the basis of western medical treatment, is taken the Chinese medicine that the present invention treats acute heart failure.Two groups of cases are all treated and within two months, are carried out effect judgement.

4, curative effect determinate standard

Clinical recent healing: cardiac function is corrected to 1 grade, and symptom, sign disappear substantially, and it is normal that every inspection recovers substantially;

Effective: cardiac function progress is more than 2 grades, and do not reach 1 grade of cardiac function, symptom, sign and every inspection obviously improve;

Effective: 1 grade of cardiac function progress, and do not reach 1 grade of cardiac function, symptom, sign and every inspection have to be afraid of to improve;

Invalid: cardiac function is without significant change, or increase the weight of, or dead.

5, statistical method

The all data of statistical method are carried out t check and x2 check, and there is significance P < 0.05 for difference.

6, result

Two groups of Clinical efficacy comparisons: clinical recent healing 17 examples for the treatment of group (28.33%), effective 32 examples (53.33%), effective 9 examples (15%), invalid 2 examples (3.33%), total effective rate is 96.67%; Clinical recent healing 4 examples of matched group (13.33%), effective 9 examples (30%), effective 11 examples (36.67%), invalid 6 examples (20%), total effective rate is 80%.Two groups of curative effects are Epidemiological Analysis by statistics, and difference has significant (P < 0.05), and treatment group curative effect is better than matched group.Treatment group clinical cure rate and obvious effective rate, to organizing obvious raising, have significant difference (P < 0.05).

Claims

1. a Chinese medicine for the treatment of acute heart failure, it is characterized in that: crude drug composition is by weight percentage, Flos Carthami 12～16%, Radix Angelicae Sinensis 9～12%, Pheretima 6～9%, Polyporus 5～9%, Herba Apocyni veneti 9～13%, Herba Adonidis 6～9%, Radix Curcumae 3～6%, Rhizoma Zingiberis 5～7%, Cortex Moutan 5～7%, Folium Perillae 3～5%, the Radix Pulsatillae 3～6%, Radix Morindae Officinalis 3～6%, Radix Asteris 3～6%, Radix Ophiopogonis 2～5%, Artemisia anethoicles Mattf 2～4%, Rhizoma Chuanxiong 3～5%, above-mentioned 16 taste crude drug are soaked to the filtrate of removing slag to obtain after decocting.