CN105749086A - Qi invigorating and tranquilization electuary for treating acute heart failure - Google Patents

Qi invigorating and tranquilization electuary for treating acute heart failure Download PDF

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CN105749086A
CN105749086A CN201610238354.9A CN201610238354A CN105749086A CN 105749086 A CN105749086 A CN 105749086A CN 201610238354 A CN201610238354 A CN 201610238354A CN 105749086 A CN105749086 A CN 105749086A
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heart failure
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invigorating
acute heart
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不公告发明人
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a Qi invigorating and tranquilization electuary for treating acute heart failure.The Qi invigorating and tranquilization electuary for treating acute heart failure is prepared from the following raw herbal materials in parts by weight: 3-9 parts of Concha Ostreae, 3-9 parts of Poria cocos, 6-10 parts of Ramulus Cinnamomi, 2-8 parts of Fructus Hippophae, 6-12 parts of Herba Agerati Conyzoidis, 5-15 parts of Semen Platycladi, 4-9 parts of Radix Salviae Miltiorrhizae, 5-9 parts of Mytilus, 2-5 parts of Radix Stemonae, 3-9 parts of Rhizoma Anemarrhenae, 25-35 parts of Radix Astragali, 4-10 parts of Rhizoma Alismatis and 6-10 parts of Os Draconis.All the selected materials are traditional Chinese medicine materials, and do not have any toxic or side effects.The composition completely accords with the traditional Chinese medicine principle and physical and mental characteristics of patients suffering from acute heart failure, on the premise of the total principle, different compositions are used for different people, functions are different, medicine sources are easy to obtain, the cost of medicinal materials is low, and burden of the patients can be reduced.

Description

The invigorating qi for tranquilization electuary for the treatment of acute heart failure
Divisional application, original applying number 2014100821925, applying date 2014.03.07, title acute heart failure invigorating qi for tranquilization Electuary and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat acute heart failure invigorating qi for tranquilization electuary and preparation side Method.
Background technology
Acute heart failure (AHF) refers to the myocardial contractive power fall of acute attack or the left heart function caused by abnormal that increases the weight of Low, cardiac load increases the weight of, and causes acute cardiac output rapid drawdown, pressure of pulmonary circulation rising, peripheral resistance to increase, causes lung to follow Ring is congested and acute pulmonary venous pleonaemia, pulmonary edema occurs and tissue, organ perfusion can be accompanied not enough and the clinical syndrome of cardiogenic shock, Most commonly seen with left heart failure.Acute heart failure can on the basis of original chronic heart failure acute exacerbation or suddenly onset, premorbid Most patients is associated with organic angiocardiopathy, can behave as shrinkage heart failure, it is also possible to show as diastolic heart failure.Acute The normal threat to life of heart failure, it is necessary to promptly rescue.
The cause of disease is as follows: 1. chronic heart failure acute exacerbation.2. Acute myocardial is downright bad or damages (1) acute coronary syndromes Levy；(2) acute severe myocarditis；(3) perinatal stage cardiomyopathy；(4) myocardial damage of drug-induced and necrosis etc..The most acute blood flow Aerodynamic blockage (1) acute valvular regurgitation or original valvular regurgitation increase the weight of；(2) hypertensive crisis；(3) severe aorta petal or two Cusp is narrow；(4) dissection of aorta；(5) cardiac tamponade；(6) acute diastolic left heart failure, is common in the elderly and accompanies control not Good hyperpietic.
Comparing with western medicine and medical practitioners, by Chinese traditional treatment, toxic and side effect is relatively light, is more vulnerable to numerous medical personnels Favor with friend patient.Application publication number CN 103520680 A(application number 201310480290.X) Chinese patent literary composition Offering and provide a kind of Chinese medicine treating acute heart failure, bulk drug composition is by weight percentage, safflower 12～16%, Radix Angelicae Sinensis 9-12%, earthworm 6-9%, umbellate pore furgus 5-9%, bluish dogbane 9-13%, adonis 6-9%, root tuber of aromatic turmeric 3-6%, rhizoma zingiberis 5-7%, the root bark of tree peony 5-7%, perilla leaf 3-5%, Chinese bulbul 3-6%, Morinda officinalis 3-6%, aster 3-6%, the 2-5% tuber of dwarf lilyturf, the old 2-4% of bacterium, Ligusticum wallichii Above-mentioned 16 taste bulk drugs are soaked, filtrate of removing slag after decocting to obtain by 3-5%.Authorization Notice No. CN 100496530C(applies for Numbers 200410018562.5) Chinese patent literature relates to a kind of Chinese medicine composition treating acute heart failure, including medium-height grass medicinal herbs Lepidium seed, Ligusticum wallichii, formula is pressed portion rate preparation and by lepidium seed or its extract 1-3 part, Ligusticum wallichii or its extract 1-2 part and is fitted Auxiliary material forms.Publication number CN 101229267A(application number 200810056134.X) relate to one and treat acute heart failure and the wind heart Sick pharmaceutical composition and preparation method thereof, it is mainly by peach kernel, safflower, Radix Angelicae Sinensis, the dried rhizome of rehmannia, river Chinese herbaceous peony, the radix paeoniae rubrathe, the root of bidentate achyranthes, balloonflower root, bavin Recklessly, long-pending reality and Radix Glycyrrhizae are made.
Although the medicine provided in prior art the most all has some curative effects on treatment acute heart failure, but part Prescription brings certain toxic and side effect, the most existing technology the most not to mend more or less can to the stomach and intestine of patient, liver kidney Effect that gas is calmed the nerves.Generally speaking, treatment for acute heart failure at present there is no preferable definite treatment by Chinese herbs medicine.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to provide one prepare simply, taking convenience, be easy to carry, The easily for a long time acute heart failure invigorating qi for tranquilization electuary of clothes and preparation method, this electuary determined curative effect and having no side effect.
The technical scheme is that
Acute heart failure invigorating qi for tranquilization electuary, is mainly prepared from by following bulk drugs, is weight portion: oyster 3-9, Poria cocos 3-9, Cassia twig 6-10, sea-buckthorn 2-8, Ageratum conyzoides 6-12, seed of Oriental arborvitae 5-15, red sage root 4-9, mussel 5-9, tuber of stemona 2-5, wind-weed 3-9, the Radix Astragali 25-35, rhizoma alismatis 4-10, keel 6-10.
Foregoing acute heart failure invigorating qi for tranquilization electuary, it is preferred that be mainly prepared from by following bulk drugs, be Weight portion: oyster 5-7, Poria cocos 5-7, cassia twig 7-9, sea-buckthorn 4-6, Ageratum conyzoides 8-10, seed of Oriental arborvitae 8-13, red sage root 6-8, mussel 6-8, Tuber of stemona 3-4, wind-weed 5-7, Radix Astragali 28-33, rhizoma alismatis 6-8, keel 7-9.
Foregoing acute heart failure invigorating qi for tranquilization electuary, the most preferably, is mainly prepared from by following bulk drugs, It is weight portion: oyster 6, Poria cocos 6, cassia twig 8, sea-buckthorn 5, Ageratum conyzoides 9, the seed of Oriental arborvitae 11, the red sage root 7, mussel 7, the tuber of stemona 3.5, the wind-weed 6, the Radix Astragali 30, rhizoma alismatis 7, keel 8.
The preparation method of described acute heart failure invigorating qi for tranquilization electuary is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 0.5-1.2 hour, cross leaching Juice, concoction merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, Filter after precipitating 8-24 hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4-5 gram of crude drug of liquid, adds cold water and is diluted to every milliliter contained 1-3 Gram, filter after precipitating 8-24 hour；
(3) filtrate is 1.0-1.3:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C hereinafter referred to as 1 always admittedly The scale of construction；
(4) add the white granulated sugar of total solid 2-5 times weight, the dextrin of 0.5-1.2 times of (preferably 0.9 times) weight, use ethanol (65%), regulate humidity, make particle with granulator, packaging.
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary, it is preferred that step (1) decocts 0.7-1 hour (preferably again 0.8 hour).
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary, it is preferred that step (1) precipitation mistake after 13-18 hour Filter (preferably 15 hours).
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary, it is preferred that step (2) is evaporated to every milliliter of liquid phase When crude drug 4.2-4.8 gram (preferably 4.5 grams).
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary, it is preferred that step (2) precipitation mistake after 13-18 hour Filter (preferably 15 hours).
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary, it is preferred that step (4) adds total solid 3-4 times and weighs The white granulated sugar (preferably 3.5 times) of amount.
Additionally provide at preparation treatment pulmonary heart disease, cardiac muscle stalk according to acute heart failure invigorating qi for tranquilization electuary described in above any one Application in plug, myocardial necrosis, anginal medicine.
Instructions of taking: for making the present invention reach optimum efficiency, when taking, each one bag, three times a day, and warm boiled water, 15 It course for the treatment of.
Used by the present invention, the pharmacology of main Chinese medicine material is as follows:
Oyster: nature and flavor: salty, is slightly cold.Gui Jing: return liver, courage, kidney channel.Effect: transquilization with heavy material, checking exuberance of yang tonifying yin, softening and resolving hard mass, receive Hold back astringent or styptic treatment for spontaneous sweating.Cure mainly: being used for insomnia of palpitating with fear, dizziness tinnitus, scrofula subcutaneous nodule, lump in the abdomen lump in the abdomen, spontaneous sweating, pass out semen and collapse band, stomachache gulps down Acid.
Poria cocos: nature and flavor: sweet, light is flat.Gui Jing: the thoughts of returning home, lung, spleen, kidney channel.Effect: clearing damp and promoting diuresis, the peaceful heart of invigorating the spleen.Main To control: for oedema oliguria. phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, has loose bowels in loose stool, confused and worried, palpitation with fear insomnia.
Cassia twig: nature and flavor: acrid, sweet, warm.Gui Jing: the thoughts of returning home, lung, bladder warp.Effect: sweating expelling pathogenic factors from muscles and skin, warming meridian is supporing yang Change gas, the flat gas that spins.Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, blood is cold through closing, joint pain, phlegm and retained fluid, oedema, and palpitaition is run quickly Globefish.
Sea-buckthorn: another name Da Er, arrow-leaved oleaster, fructus hippophae, big Er Buxing, vinegar willow, acid sting Liu Liu, sour, its examine a day Cannes, acid thorn, Black thorn, yellow acid thorn, acid thorn thorn, fructus hippophae and oil have the highest medical value, it is possible to decrease cholesterol, cure angina pectoris etc. and make With, also prevent and treat the effect of coronary atherosclerotic heart disease；Have and eliminate the phlegm, cough-relieving, relieving asthma and treat chronic bronchitis Effect；Gastric duodenal ulcer and indigestion etc. can be treated, to chronic superficial gastritis, atrophic gastritis, colitis Evident in efficacy etc. illness；To burn, scald, cutter burns, frostbite has good therapeutic action；Cervical erosion is had good controlling Therapeutic effect.Taste acid；Puckery；Warm in nature, relieving cough and reducing sputum；Stomach strengthening and digestion promoting；Promoting blood circulation to remove blood stasis.Main coughing with a lot of sputum；Pulmonary abscess；Indigestion；Food Long-pending stomachache；Stomachache；Enteritis；Amenorrhoea；Fall dozen stasis of blood to swell.
Ageratum conyzoides: hardship pungent, micro-is cool.Expelling wind and clearing away heat, pain relieving, hemostasis, arrange stone.For the infection of the upper respiratory tract, tonsillitis, Sphagitis, acute gastroenteritis, stomachache, stomachache, uterine bleeding, kidney stone, vesical calculus；Eczema is controlled in external application, thrush, ulcerative carbuncle pyogenic infections, Cellulitis, the ulcer of lower limb, tympanitis, traumatism and bleeding.
The seed of Oriental arborvitae: nature and flavor: sweet is flat.Gui Jing: the thoughts of returning home, kidney, large intestine channel.Effect: mental-tranquilization, hidroschesis, ease constipation.
Cure mainly: have a sleepless night for dysphoria, palpitation and severe palpitation, night sweat due to yin deficiency, the dry constipation of intestines.
The red sage root: nature and flavor: bitter, is slightly cold.Gui Jing: the thoughts of returning home, Liver Channel.Effect: stasis-dispelling and pain-killing, invigorates blood circulation and stimulates the menstrual flow, and clear away heart-fire relieving restlessness. Curing mainly: for irregular menstruation, through closing dysmenorrhoea, lump in the abdomen is gathered, and chest and abdomen shouting pain, hot numbness pain, sore swells and ache, dysphoria and insomnia；Liver spleen Enlargement, angina pectoris.
Mussel: salty, temperature.Filling liver kidney, benefiting essence-blood, disappear goiter and tumor.Control consumptive disease thin thin, dizziness, night sweat, impotence, pain in the back, spit blood, Uterine bleeding, under band, goiter and tumor, hernia lump in the abdomen.Energy tonifying five zang organs, Yiyang thing, manage waist tinea pedis, disappear place food, except cold air in abdomen, Xuan addiction.
The tuber of stemona: nature and flavor: sweet, bitter, tepor.Gui Jing: return lung channel.Effect: moistening lung to lower qi cough-relieving, desinsection.Cure mainly: use Cough in new chronic cough, pulmonary tuberculosis cough, pertussis；Outer for head louse, body louse, enterobiasis, pruritus vulvae.The honey tuber of stemona moistens the lung and relieve the cough.For the moon Consumptive disease is coughed.
The wind-weed: nature and flavor: bitter, sweet, cold.Gui Jing: return lung, stomach, kidney channel.Effect: clearing heat-fire, promotes the production of body fluid and moisturizes.Cure mainly: For fever caused by exogenous pathogenic factors. high hot polydipsia, lung-heat type cough, osteopyrexia and fever, interior heat quenches one's thirst, the dry constipation of intestines.
The Radix Astragali: effect: invigorating qi for strengthening superficies, diuresis torr poison, apocenosis, expelling pus and promoting granulation.Curing mainly: weak for the deficiency of vital energy, food is few just Half congealed, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer difficulty is burst, and bursts for a long time and does not holds back, and flaccidity of limbs due to deficiency of blood is yellow, interior Heat is quenched one's thirst；Chronic rephrilis protinuria, diabetes.
Rhizoma alismatis: nature and flavor: sweet, cold.Gui Jing: return kidney, bladder warp.Effect: diuresis, clearing away damp-heat.Cure mainly: for urine Unfavorable. oedema turgor, oliguria of having loose bowels, phlegmatic vertigo, heat drenches puckery pain；High fat of blood.
Keel: nature and flavor: sweet puckery, flat, Gui Jing: the heart, liver, kidney, large intestine channel.Transquilization with heavy material tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, hemostasis Puckery intestines, myogenic sore.Controlling frightened epilepsy demented, palpitation is forgetful, insomnia and dreamful sleep, spontaneous sweating, stranguria with turbid discharge of passing out semen, and tells nosebleed and has blood in stool, uterine bleeding band Under, rush down dysentery prolapse of the anus, ulcer does not closes up.
The Chinese medicine composition scientific formula that the present invention provides, the preparation method of its formulation is simple, products obtained therefrom taking convenience, It is easy to carry.In addition, the excellent results of the present invention is also manifested by:
1, selected materials is all traditional Chinese medicine material, without any side effects；
2, this prescription complies fully with traditional Chinese medicine principle and acute heart failure, cardiac's body and mind feature, on the premise of general principle, Can have different prescription according to different crowd, function is different, most importantly can play effect of invigorating qi for tranquilization.
3, medicine source is easy to get, and medicinal material is with low cost, it is possible to alleviate patient burden.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1 acute heart failure invigorating qi for tranquilization electuary, is mainly prepared from by following bulk drugs, is weight portion (every part 5g): oyster 3, Poria cocos 3, cassia twig 6, sea-buckthorn 2, Ageratum conyzoides 6, the seed of Oriental arborvitae 5, the red sage root 4, mussel 5, the tuber of stemona 2, the wind-weed 3, the Radix Astragali 25, pool Rush down 4, keel 6.
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 0.5 hour, cross leaching juice, medicine Juice merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, precipitates 8 Filter after hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3 gram, Filter after precipitating 8 hours；
(3) filtrate is 1.0-1.3:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C hereinafter referred to as 1 always admittedly The scale of construction；
(4) add the white granulated sugar of total solid 2-5 times weight, the dextrin of 0.5 times of weight, with ethanol (65%), regulate humidity, use Granulator makes particle, packaging.
Embodiment 2 acute heart failure invigorating qi for tranquilization electuary, is mainly prepared from by following bulk drugs, is weight portion (every part 10g): oyster 9, Poria cocos 9, cassia twig 10, sea-buckthorn 8, Ageratum conyzoides 12, the seed of Oriental arborvitae 15, the red sage root 9, mussel 9, the tuber of stemona 5, the wind-weed 9, the Radix Astragali 35, rhizoma alismatis 10, keel 10.
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 1.2 hours, cross leaching juice, medicine Juice merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, precipitates 24 Filter after hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 5 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3 gram, Filter after precipitating 24 hours；
(3) filtrate is 1.0-1.3:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C hereinafter referred to as 1 always admittedly The scale of construction；
(4) add the white granulated sugar of 5 times of weight of total solid, the dextrin of 1.2 times of weight, with ethanol (65%), regulate humidity, use Particle made by grain machine, packaging.
Model case one: poplar ××, man, 56 years old.Main suit: ictal pectoralgia 5 days, paroxysmal dyspnea 2 hours.Patient Suddenly felt secret anguish after breastbone, scope about hand size without obvious inducement before 5 days, have a rest and sublingual administration monobel pain is without slow Solving, pain is takeed on and the radiation of left back to the left, accompanies Nausea and vomiting, profuse sweating, goes to a doctor to local hospital, examines as " acute heart failure ", give Red cell morphology in urine, pain relief after 2 hours；After defecating firmly before 2 hours, occur suddenly having difficulty in breathing, pant, force seat Position, accompanies profuse sweating, agitation, coughs, coughs pink foam phlegm, takes a turn for the better through rescuing, and previously without hypertension history, has 20 years smoking histories, 20/day, without being addicted to drink, after drug withdrawal half a year, there are again the symptoms such as feeling of oppression and pain in the chest in patient's sensation, and symptom ratio is more serious, youngster It is the best to treatment acute heart failure effect that son hears of electuary of the present invention, moreover it is possible to invigorating qi for tranquilization, has just bought 6 courses for the treatment of and has taken.
Take embodiment 2 gained invigorating qi for tranquilization electuary, each one bag, three times a day, and warm boiled water, 15 days courses for the treatment of. Taking 30 days, pectoralgia, cough alleviate, and the most confusing also alleviate, and the amount of receiving increases, spirit can, take 5 months, symptom eliminates, and night sleeps Peace, vexed removes, and strength increases, receive food can, following the service 12 months, any discomfort does not occurs when patient takes, self-induction is fully recovered.
Embodiment 3 acute heart failure invigorating qi for tranquilization electuary, is mainly prepared from by following bulk drugs, is weight portion (every part 15g): oyster 5, Poria cocos 5, cassia twig 7, sea-buckthorn 4, Ageratum conyzoides 8, the seed of Oriental arborvitae 8, the red sage root 6, mussel 6, the tuber of stemona 3, the wind-weed 5, the Radix Astragali 28, Rhizoma alismatis 6, keel 7.
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 0.7 hour, cross leaching juice, medicine Juice merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, precipitates 13 Filter after hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.2 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3 Gram, filter after precipitating 13 hours；
(3) filtrate is 1.0-1.3:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C hereinafter referred to as 1 always admittedly The scale of construction；
(4) add the white granulated sugar of 3 times of weight of total solid, the dextrin of 0.8 times of weight, with ethanol (65%), regulate humidity, use Particle made by grain machine, packaging.
Model case two: king XX, 88 years old, male sex's hypertension 3 grades for many years, before 2 years, be in hospital by cerebral infarction, and happen suddenly left heart failure , double lungs are heard a large amount of dry moist rales and gurgling weith sputum sound, blood pressure 240/135mmhg, HR140 beat/min, are breathed 45 times through cardiac stimulant Diuresis, lightening heart load, hypotensive, relievining asthma etc. processes, present blood pressure is 135/78mmhg, heart rate 130 times every point, exhales Inhale 30 times every point, but patient's no urine always, furosemide does not has intravenous injection 120mg altogether, till now or no urine, and breathes Promoting the most very much, a large amount of dry moist rale of double lungs and gurgling weith sputum sound, sleep quality declines, and is " acute heart failure " through preliminary diagnosis, Owing to patient age is bigger, doctor takes electuary of the present invention.
Taking embodiment 3 gained invigorating qi for tranquilization electuary, each one bag, three times a day, warm boiled water, 15 days is a treatment Journey, takes 15 days, and malaise symptoms makes moderate progress, and spirit also improves, and appetite is cumulative, takes 5 months, and malaise symptoms changes substantially Kind, following the service 2 months, patient's self-induction is fully recovered.
Embodiment 4 acute heart failure invigorating qi for tranquilization electuary, is mainly prepared from by following bulk drugs, is weight portion (every part 20kg): oyster 7, Poria cocos 7, cassia twig 9, sea-buckthorn 6, Ageratum conyzoides 10, the seed of Oriental arborvitae 13, the red sage root 8, mussel 8, the tuber of stemona 4, the wind-weed 7, the Radix Astragali 33, rhizoma alismatis 8, keel 9.
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 1 hour, cross leaching juice, concoction Merging, by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, and precipitation 18 is little Filter time after；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.8 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3 Gram, filter after precipitating 18 hours；
(3) filtrate is 1.0-1.3:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C hereinafter referred to as 1 always admittedly The scale of construction；
(4) add the white granulated sugar of 4 times of weight of total solid, the dextrin of 1 times of weight, with ethanol (65%), regulate humidity, use particle Particle made by machine, packaging.
Embodiment 5 acute heart failure invigorating qi for tranquilization electuary, is mainly prepared from by following bulk drugs, is weight portion (every part 30g): oyster 6, Poria cocos 6, cassia twig 8, sea-buckthorn 5, Ageratum conyzoides 9, the seed of Oriental arborvitae 11, the red sage root 7, mussel 7, the tuber of stemona 3.5, the wind-weed 6, the Radix Astragali 30, rhizoma alismatis 7, keel 8.
The preparation method of above-mentioned acute heart failure invigorating qi for tranquilization electuary is:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 0.8 hour, cross leaching juice, medicine Juice merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, precipitates 15 Filter after hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.5 grams of crude drugs of liquid, adds cold water and is diluted to every milliliter contained 1-3 Gram, filter after precipitating 15 hours；
(3) filtrate is 1.0-1.3:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C hereinafter referred to as 1 always admittedly The scale of construction；
(4) add the white granulated sugar of 3.5 times of weight of total solid, the dextrin of 0.9 times of weight, with ethanol (65%), regulate humidity, use Granulator makes particle, packaging.
The clinical practice of test example 1 embodiment 5 gained treatment acute heart failure invigorating qi for tranquilization electuary: in September, 2011-2013 Year December, screening 200 example acute heart failure patient, wherein women 100 examples in 3 second-rank first class hospitals, the male sex 100 example, the age is Big 90 years old, minimal ages 35 years old, 65 years old mean age.Before test 2 weeks, this crowd is carried out Continuous Observation, record symptom And change, it being randomly divided into two groups, experimental group and control group, experimental group takes embodiment 5 products obtained therefrom, and control group takes other medicine Product (conventional medication such as 'Shen Gui ' capsule, pills for curing heart disease).Using method is: each one bag, three times a day, warm boiled water, 15 days one The course for the treatment of.Curative effect situation criterion: cure: take 3 courses for the treatment of of this product, malaise symptoms disappears, and energy and muscle power are remarkably reinforced, and sleep Dormancy Quality advance；Effective: taking 3 courses for the treatment of of this product, malaise symptoms alleviates or partial disappearance, and energy and muscle power have strengthened；Nothing Effect: taking 3 courses for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 35-90 year acute heart failure crowd's treatment results
Result for the treatment of: cure 74 examples (74%), effective 25 examples (25%), invalid 1 example (1%), total effective rate 99%.Effect is the most excellent In control group.
Take period self-induction symptom and muscle power spirit change is as shown in table 2.
Table 2:
Taking electuary of the present invention 30 days, more than 52% feel has taken a turn for the better, and malaise symptoms improves or disappears, and spirit, muscle power increase By force；Taking 60 days, more than 75% feel has taken a turn for the better, and malaise symptoms improves or disappears, and spirit, muscle power strengthen；Take 90 days, More than 98% feel has taken a turn for the better, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and electrocardio diagram heart blood supply substantially changes Kind, some patients self-induction is fully recovered.Experimental group is taken more than 90 days, efficient up to more than 93%, and control group is up to 80%, Selected materials is all traditional Chinese medicine material, without any side effects；This prescription complies fully with traditional Chinese medicine principle and cardiac Body and mind feature, on the premise of general principle, can have different prescription according to different crowd, and function is different.Medicine source is easy to get, medicinal material cost Cheap, it is possible to alleviate patient burden.

Claims (7)

1. acute heart failure invigorating qi for tranquilization electuary, is characterized in that, is mainly prepared from by following bulk drugs, is weight portion: oyster 3, Poria cocos 3, cassia twig 6, sea-buckthorn 2, Ageratum conyzoides 6, the seed of Oriental arborvitae 5, the red sage root 4, mussel 5, the tuber of stemona 2, the wind-weed 3, the Radix Astragali 25, rhizoma alismatis 4, keel 6。
The most according to claim 1, the preparation method of acute heart failure invigorating qi for tranquilization electuary, is characterized in that, step is as follows:
(1) juice is decocted in the bulk drug mixing put in order, decoct altogether three times, every time after water boils, then decoct 0.5-1.2 hour, cross leaching Juice, concoction merges, and by thin film evaporation to every milliliter contained 1-3 gram, the ethanol (95%) adding one times of weight is stirring while adding, Filter after precipitating 8-24 hour；
(2) filtrate is by thin film evaporation to every milliliter of suitable 4-5 gram of crude drug of liquid, adds cold water and is diluted to every milliliter contained 1-3 Gram, filter after precipitating 8-24 hour；
(3) filtrate is 1.0-1.3:1 by thin film evaporation to medicinal extract shape, concentrate specific gravity control, lets cool to 80 DEG C the most admittedly The scale of construction；
(4) add the white granulated sugar of total solid 2-5 times weight, the dextrin of 0.5-1.2 times of (preferably 0.9 times) weight, use ethanol (65%), regulate humidity, make particle with granulator, packaging.
Preparation method the most according to claim 2, is characterized in that, step (1) decocts 0.7-1 hour (preferably 0.8 hour) again.
Preparation method the most according to claim 2, is characterized in that, step (1) filters (preferably 15 after precipitating 13-18 hour Hour).
Preparation method the most according to claim 2, is characterized in that, step (2) is evaporated to every milliliter of suitable crude drug of liquid 4.2-4.8 gram (preferably 4.5 grams).
Preparation method the most according to claim 2, is characterized in that, step (2) filters (preferably 15 after precipitating 13-18 hour Hour).
Preparation method the most according to claim 2, is characterized in that, step (4) adds the white granulated sugar of total solid 3-4 times weight (preferably 3.5 times).
CN201610238354.9A 2014-03-07 2014-03-07 Qi invigorating and tranquilization electuary for treating acute heart failure Withdrawn CN105749086A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102218084A (en) * 2011-06-08 2011-10-19 华夏先葆(北京)中药研究院有限公司 Traditional Chinese medicament health preserving preparation having effects of enhancing immunity, resisting ageing and improving sub-health
CN103520680A (en) * 2013-09-29 2014-01-22 姜浩 Traditional Chinese medicine for treating acute heart failure

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102218084A (en) * 2011-06-08 2011-10-19 华夏先葆(北京)中药研究院有限公司 Traditional Chinese medicament health preserving preparation having effects of enhancing immunity, resisting ageing and improving sub-health
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