CN105412745A - Yang-warming and qi-tonifying granules for treating myocardial ischemia and preparation method of granules - Google Patents
Yang-warming and qi-tonifying granules for treating myocardial ischemia and preparation method of granules Download PDFInfo
- Publication number
- CN105412745A CN105412745A CN201510892564.5A CN201510892564A CN105412745A CN 105412745 A CN105412745 A CN 105412745A CN 201510892564 A CN201510892564 A CN 201510892564A CN 105412745 A CN105412745 A CN 105412745A
- Authority
- CN
- China
- Prior art keywords
- parts
- myocardial ischemia
- granules
- radix
- invigorating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/612—Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses yang-warming and qi-tonifying granules for treating myocardial ischemia and a preparation method of the granules. The granules are prepared from the following medicinal raw materials in parts by weight: 3-9 parts of concha ostreae, 3-9 parts of poria cocos, 6-10 parts of cassia twig, 2-8 parts of fructus hippophae, 3-12 parts of tropic ageratum herb, 3-6 parts of swimming crab, 4-9 parts of radix salviae miltiorrhizae, 5-9 parts of mussel, 2-5 parts of radix stemonae, 3-9 parts of rhizoma anemarrhenae, 4-10 parts of rhizoma alismatis and 25-30 parts of radix astragali. The granules, which are completely prepared from traditional Chinese medicinal materials, are free from toxic and side effects; the prescription completely conforms to the principle of traditional Chinese medicine and the physical and mental characteristics of patients with myocardial ischemia; on the precondition of general principle, various prescriptions, which are different in function, can be provided for different people; and medicine sources are easily available and the medicinal materials are low in cost, so that the burden in the patients can be reduced.
Description
divisional application, original applying number 2014100819198, applying date 2014.03.07, title myocardial ischemia warming YANG and invigorating QI electuary and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat myocardial ischemia warming YANG and invigorating QI electuary and preparation method.
Background technology
Myocardial ischemia, refer to that the hemoperfusion of heart reduces, cause the oxygen supply of heart to reduce, energy metabolism of myocardial is abnormal, can not support a kind of pathological state of normal heart action.The coronary stenosis that coronary atherosclerosis causes or obturation cause main, the modal cause of disease of myocardial ischemia, and then cause myocardial ischemia-anoxemia, " coronary heart disease " that the heart disease caused the thus i.e. large daily life of a family is said, so coronary heart disease is myocardial ischemia " arch-criminal ".The health of myocardial ischemia serious harm middle-aged and elderly people, in recent years along with growth in the living standard, coronary atherosclerosis presents the trend of rejuvenation, and the performance of myocardial ischemia also appears in the youngster in some 20-30 years.
One, latent coronary heart disease: refer to without clinical symptoms, but the coronary heart disease having myocardial ischemia objective evidence (change of electrocardiogram typical case ischemic ST, Myocardial Perfusion minimizing etc.).Large quantifier elimination finds in recent years, in the acute Sudden Death of about 25% ~ 50%, before death without angina pectoris history of attack, but in the postmortem of nearly 90%, finds that these have serious coronary atherosclerosis per capita.Even if occurring in the patient of acute myocardial infarction, the patient of 30% is also being still had not have symptom.Silent ischemia can occur in dissimilar angina pectoris.Patient is transference cure but still have myocardial ischemia to exist after treatment, and this is the important indicator of prognosis mala.This type patient also may transfer myocardial infarction to suddenly, also may develop into myocardial fibrosis gradually and occur cardiac enlargement, and heart failure or arrhythmia occur, and few patients also may die suddenly.Therefore, silent myocardial ischemia should cause the enough attention of people, Timeliness coverage, and gives Clinics and Practices early.Two, angina pectoris: be coronary insufficiency, cardiac muscle sharply, its feature of clinical syndrome that temporary transient ischemia and anoxia cause is that sample pain perception is squeezed in paroxysmal shirtfront, left upper extremity can be emitted to, often betide labour, catch cold, excited, when to be satiated with food etc., last for several minutes, the disappearances such as rest or sublingual administration nitroglycerin., there is coronary blood for sharply reducing or interrupting in three, myocardial infarction type: be on the basis of coronary artery pathological changes, makes the part cardiac muscle acute necrosis of corresponding cardiac muscle seriously and enduringly caused by acute ischemia.Myocardial infarction is often caused by the basis of coronary atherosclerosis, secondary thrombus is formed.Four, ischemic cardiomyopathy: be due to atherosclerotic lesion make cardiac muscle oxygen supply and aerobic imbalance and cause myocardial cell minimizings, necrosis, myocardial fibrosis, MS formation.Its feature is that heart becomes stiff, expands gradually, and arrhythmia and heart failure occur.Five, sudden death type: be naturally-occurring, unexpected sudden death.Sudden death coronary heart disease is apt to occur in season in midwinter, and how little the age is, is due on atherosclerotic basis, there is coronary vasospasm or thromboembolism, causing Acute myocardial ischemia, cause local electric physiologic derangement, causing caused by temporary transient severe arrhythmia (as quivered in room) etc.
Compare with western medicine and medical practitioners, by Chinese traditional treatment, toxic and side effects is comparatively light, is more vulnerable to the favor of numerous medical personnels and friend patient.CN103120724A(application number 201110371229.2) Chinese patent literature provide a kind of medicine for the treatment of myocardial ischemia, by Radix Ginseng 2-6 part, Radix Scrophulariae 4-8 part, Radix Salviae Miltiorrhizae 6-10 part, Radix Astragali 8-12 part, Flos Lonicerae 2-3 part, Radix Notoginseng 2-4 part, Hirudo 4-8 part, Rhizoma Chuanxiong 2-4 part, Radix Polygalae 3-6 part, Semen Ziziphi Spinosae 8-12 part, Radix Angelicae Sinensis 8-12 part, Fructus Schisandrae Chinensis 5-13 part, Radix Glycyrrhizae 3-12 part, Cinnabaris 1-2 part.Application publication number CN102232997A(application number 201010153585.2) Chinese patent literature relate to a kind of medicine for the treatment of myocardial ischemia and preparation method thereof,, described active ingredient is prepared by the raw material of following weight proportion: Peucedanum praeruptorum DUNN 1-30 part and Radix Glycyrrhizae 1-5 part.Authorization Notice No. CN102526523B(application number 201210020164.1) relate to a kind of Chinese medicine for the treatment of myocardial ischemia, be made up of the component of following weight portion: Radix Ginseng 2 ~ 3 parts, Radix Angelicae Sinensis 2-4 part, Rhizoma Chuanxiong 2-4 part, Semen Persicae 1-3 part, Radix Ophiopogonis 2-3 part, Semen Ziziphi Spinosae 2-3 part, Caulis Bambusae In Taenia 1-3 part, Radix Rehmanniae Preparata 2-3 part, Cinnabaris 1-2 part, Radix Panacis Quinquefolii 2-4 part.
Although the medicine provided in prior art more or less all has some curative effects on treatment myocardial ischemia, but part prescription more or less can give the gastrointestinal of patient, Liver and kidney brings certain toxic and side effects, and moreover existing technology does not all have effect of warming YANG and invigorating QI.Generally speaking, at present desirable definite treatment by Chinese herbs medicine be there is no for the treatment of myocardial ischemia.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, easily the myocardial ischemia warming YANG and invigorating QI electuary of clothes and preparation method for a long time.This electuary determined curative effect and having no side effect.
Technical scheme of the present invention is:
Myocardial ischemia warming YANG and invigorating QI electuary, is prepared from primarily of following bulk drugs, is weight portion: Concha Ostreae 3-9, Poria 3-9, Ramulus Cinnamomi 6-10, Fructus Hippophae 2-8, Herba Agerati Conyzoidis 3-12, Charybdis japonica 3-6, Radix Salviae Miltiorrhizae 4-9, Mytilus 5-9, Radix Stemonae 2-5, Rhizoma Anemarrhenae 3-9, Rhizoma Alismatis 4-10, Radix Astragali 25-30.
Foregoing myocardial ischemia warming YANG and invigorating QI electuary, preferably, is prepared from primarily of following bulk drugs, is weight portion: Concha Ostreae 5-7, Poria 5-7, Ramulus Cinnamomi 7-9, Fructus Hippophae 4-6, Herba Agerati Conyzoidis 5-10, Charybdis japonica 4-5, Radix Salviae Miltiorrhizae 6-8, Mytilus 6-8, Radix Stemonae 3-4, Rhizoma Anemarrhenae 5-7, Rhizoma Alismatis 6-8, Radix Astragali 26-28.
Foregoing myocardial ischemia warming YANG and invigorating QI electuary, more preferably good, be prepared from primarily of following bulk drugs, be weight portion: Concha Ostreae 6, Poria 6, Ramulus Cinnamomi 8, Fructus Hippophae 5, Herba Agerati Conyzoidis 8, Charybdis japonica 4.5, Radix Salviae Miltiorrhizae 7, Mytilus 7, the Radix Stemonae 3.5, the Rhizoma Anemarrhenae 6, Polyporus 9, Rhizoma Alismatis 7, the Radix Astragali 27.
The preparation method of described myocardial ischemia warming YANG and invigorating QI electuary is:
(1) juice is decocted in the crude drug put in order mixing, decoct three times altogether, at every turn after water boils, decoct 0.3-0.8 hour again, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-2 gram, ethanol (95%) the limit edged adding one times of weight stirs, and precipitates after 8-24 hour and filters;
(2) filtrate is by thin film evaporation to the every milliliter of suitable 4-5 of medicinal liquid gram crude drug, adds cold water and is diluted to every milliliter contained 1-2 gram, precipitates after 10-20 hour and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.0-1.3:1, lets cool to 80 DEG C hereinafter referred to as total solid;
(4) add the white sugar of total solid 1-3 times of weight, the dextrin of 0.8-1.2 times of (preferably 0.9 times) weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary, preferably, step (1) is decocted 0.4-0.6 hour (preferably 0.5 hour) again.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary, preferably, step (1) precipitation filtered (preferably 15 hours) after 13-18 hour.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary, preferably, step (2) is evaporated to every milliliter of suitable crude drug 4.2-4.8 of medicinal liquid gram (preferably 4.5 grams).
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary, preferably, step (2) precipitation filtered (preferably 15 hours) after 13-18 hour.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary, preferably, step (4) adds the white sugar (preferably 2 times) of total solid 1.5-2.5 times of weight.
The application in preparation treatment pulmonary heart disease, myocardial infarction, myocardial necrosis, anginal medicine is additionally provided according to myocardial ischemia warming YANG and invigorating QI electuary described in any one above.
Instructions of taking: for making the present invention reach optimum efficiency, when taking, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Concha Ostreae: nature and flavor: salty, is slightly cold.Gui Jing: return liver, gallbladder, kidney channel.Effect: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating.Cure mainly: for insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Poria: nature and flavor: sweet, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Curing mainly: for edema oliguria. phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Ramulus Cinnamomi: nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Fructus Hippophae: another name Da Er, Fructus Elaeagni Angustifoliae, fructus hippophae, large Er Buxing, vinegar willow, acid thorn, sour Liu Liu, it examines a day Cannes, acid thorn, black thorn, yellow acid thorn, acid are stung, Fructus Hippophae and oil have very high medical value, cholesterol can be reduced, cure the effects such as angina pectoris, prevent and treat the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can gastric duodenal ulcer and dyspepsia etc. be treated, evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Good therapeutical effect is had to burn, scald, cutter burning, cold injury; Good therapeutic effect is had to cervical erosion.Sour in the mouth; Puckery; Warm in nature, relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; Promoting blood circulation to remove blood stasis.Main cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal is scorching; Amenorrhea; Traumatic injury congestive edema.
Herba Agerati Conyzoidis: pungent, micro-hardship is cool.Expelling wind and clearing away heat, pain relieving, hemostasis, calculus.For upper respiratory tract infection, tonsillitis, pharyngolaryngitis, acute gastroenteritis, stomachache, stomachache, metrorrhagia, renal calculus, vesical calculus; Eczema is controlled in external, thrush, carbuncle pyogenic infections from tumour or sore, cellulitis, ulcer of the lower limb, otitis media, traumatic hemorrhage.
Charybdis japonica: Charybdis japonica and Scylla serrata (Forskal)..Belong to Crustachia, Portumidae.Scylla serrata (Forskal). is gained the name because body colour is dark green.Scylla serrata (Forskal). carapace is ovalize slightly, and smooth surface, central authorities slightly swell, and subregion is not obvious.Feeding habits are very assorted, based on animal food.Based on Mollusca and microcrustacean in food composition, stomach contains the shell edge often occurring Bivalve in thing, twisting part relic, operculum gastropodous, incomplete spiral shell axle, the deformed limb of square Eriocheir sinensis class and carapace fragment.Property violent, carnivorous, staple food fish and shrimp shellfish.Delicious meat, nutritious, have effect of nourishing and fit keeping function concurrently.
Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.Cure mainly: for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Mytilus: salty, temperature.Invigorating the liver and kidney, benefiting essence-blood, disappear goiter.Control asthenia weakness and emaciation, dizzy, night sweat, sexual impotence, lumbago, spits blood, metrorrhagia, leukorrhagia, goiter, hernia abdominal mass.Energy tonifying five ZANG-organs, Yiyang thing, reason waist beriberi, disappear dyspepsia, except cold air in abdomen, mass beside the umbilicus.
The Radix Stemonae: nature and flavor: sweet, bitter, tepor.Gui Jing: return lung meridian.Effect: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cure mainly: cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.
The Rhizoma Anemarrhenae: nature and flavor: bitter, sweet, cold.Gui Jing: return lung, stomach, kidney channel.Effect: clearing away heat-fire, promotes the production of body fluid and moisturizes.Curing mainly: for fever caused by exogenous pathogenic factors. high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Rhizoma Alismatis: nature and flavor: sweet, cold.Gui Jing: return kidney, urinary bladder channel.Effect: diuresis, clearing away damp-heat.Cure mainly: for dysuria. edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cure mainly: weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Chinese medicine composition scientific formula provided by the invention, the preparation method of its dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,selected materials is all Chinese medicine material, without any side effects;
2,this prescription meets Chinese medicine principle and myocardial ischemia, cardiac's body and mind feature completely, under the prerequisite of general principle, can have different prescription according to different crowd, and function is different, most importantly can play effect of warming YANG and invigorating QI.
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1myocardial ischemia warming YANG and invigorating QI electuary, is prepared from primarily of following bulk drugs, is weight portion (every part of 5g): Concha Ostreae 3, Poria 3, Ramulus Cinnamomi 6, Fructus Hippophae 2, Herba Agerati Conyzoidis 3, Charybdis japonica 3, Radix Salviae Miltiorrhizae 4, Mytilus 5, the Radix Stemonae 2, the Rhizoma Anemarrhenae 3, Rhizoma Alismatis 4, the Radix Astragali 25.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary:
(1) juice is decocted in the crude drug put in order mixing, decoct three times altogether, at every turn after water boils, decoct 0.3 hour again, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-2 gram, ethanol (95%) the limit edged adding one times of weight stirs, and precipitates after 8 hours and filters;
(2) filtrate is by thin film evaporation to every milliliter of suitable 4 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-2 gram, precipitates after 10 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.0-1.3:1, lets cool to 80 DEG C hereinafter referred to as total solid;
(4) add the white sugar of total solid 1 times of weight, the dextrin of 0.8 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging.
model case one:king XX
,50 years old, male, Jinan, Shandong Province personage, hypertension 3 grades for many years, before 2 years, cerebral infarction is in hospital, burst left heart failure, two lung hears a large amount of dry moist rale and rale sound, blood pressure 240/135mmhg, HR140 beat/min, breathe 45 times through heart tonifying diuresis, lightening heart load, blood pressure lowering, the process such as to relieving asthma, present blood pressure is 135/78mmhg, heart rate 130 per minutes, breathe 30 per minutes, but patient does not urinate always, furosemide has intravenous injection 120mg altogether, do not urinate till now or, and breathe still very short, the a large amount of dry moist rale of two lung and rale sound, sleep quality declines, often there is the symptoms such as sensation of oppression over the chest with shortness of breath recently, electrocardiogram has ST section, " myocardial ischemia " through preliminary diagnosis, because patient age is larger, doctor takes electuary of the present invention.
Taking embodiment 1 gained invigorating QI and tranquilization electuary, each one bag, every day 3 times, warm boiled water, 10 days is a course for the treatment of, take 20 days, malaise symptoms makes moderate progress, and spirit has also improved, and appetite is cumulative, take 5 months, malaise symptoms improves substantially, following the service 2 months, and patient's self-induction is fully recovered.
embodiment 2myocardial ischemia warming YANG and invigorating QI electuary, is prepared from primarily of following bulk drugs, is weight portion (every part of 10g): Concha Ostreae 9, Poria 9, Ramulus Cinnamomi 10, Fructus Hippophae 8, Herba Agerati Conyzoidis 12, Charybdis japonica 6, Radix Salviae Miltiorrhizae 9, Mytilus 9, the Radix Stemonae 5, the Rhizoma Anemarrhenae 9, Rhizoma Alismatis 10, the Radix Astragali 30.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary is:
(1) juice is decocted in the crude drug put in order mixing, decoct three times altogether, at every turn after water boils, decoct 0.8 hour again, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-2 gram, ethanol (95%) the limit edged adding one times of weight stirs, and precipitates after 24 hours and filters;
(2) filtrate is by thin film evaporation to every milliliter of suitable 5 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-2 gram, precipitates after 20 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.0-1.3:1, lets cool to 80 DEG C hereinafter referred to as total solid;
(4) add the white sugar of total solid 3 times of weight, the dextrin of 1.2 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging.
embodiment 3myocardial ischemia warming YANG and invigorating QI electuary, is prepared from primarily of following bulk drugs, is weight portion (every part of 15g): Concha Ostreae 5, Poria 5, Ramulus Cinnamomi 7, Fructus Hippophae 4, Herba Agerati Conyzoidis 5, Charybdis japonica 4, Radix Salviae Miltiorrhizae 6, Mytilus 6, the Radix Stemonae 3, the Rhizoma Anemarrhenae 5, Rhizoma Alismatis 6, the Radix Astragali 26.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary is:
(1) juice is decocted in the crude drug put in order mixing, decoct three times altogether, at every turn after water boils, decoct 0.4 hour again, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-2 gram, ethanol (95%) the limit edged adding one times of weight stirs, and precipitates after 13 hours and filters;
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.2 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-2 gram, precipitates after 13 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.0-1.3:1, lets cool to 80 DEG C hereinafter referred to as total solid;
(4) add the white sugar of total solid 1.5 times of weight, the dextrin of 0.8 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging.
embodiment 4myocardial ischemia warming YANG and invigorating QI electuary, is prepared from primarily of following bulk drugs, is weight portion (every part of 20kg): Concha Ostreae 7, Poria 7, Ramulus Cinnamomi 9, Fructus Hippophae 6, Herba Agerati Conyzoidis 10, Charybdis japonica 5, Radix Salviae Miltiorrhizae 8, Mytilus 8, the Radix Stemonae 4, the Rhizoma Anemarrhenae 7, Rhizoma Alismatis 8, the Radix Astragali 28.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary is:
(1) juice is decocted in the crude drug put in order mixing, decoct three times altogether, at every turn after water boils, decoct 0.6 hour again, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-2 gram, ethanol (95%) the limit edged adding one times of weight stirs, and precipitates after 18 hours and filters;
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.8 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-2 gram, precipitates after 18 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.0-1.3:1, lets cool to 80 DEG C hereinafter referred to as total solid;
(4) add the white sugar of total solid 2.5 times of weight, the dextrin of 1 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging.
model case two: poplar ××, man, 56 years old.Main suit: ictal chest pain 5 days, paroxysmal dyspnea 2 hours.Patient felt suddenly dull pain after breastbone without obvious inducement before 5 days, scope is about hand size, rest and sublingual administration nitroglycerin pain are without alleviation, pain is takeed on left and the radiation of left back, companion Nausea and vomiting, profuse sweating, go to a doctor to local hospital, examine as " myocardial ischemia ", give red cell morphology in urine, pain relief after 2 hours; Defecated before 2 hours firmly, occur suddenly dyspnea, pant, compulsive sitting position, companion profuse sweating, agitation, coughing, cough pink foam expectorant, taking a turn for the better through rescuing, previously without hypertension history, there are 20 years smoking histories, 20/day, without being addicted to drink, after drug withdrawal half a year there is the symptoms such as feeling of oppression and pain in the chest again in patient's sensation, and symptom is than more serious in the past, it is very good to treatment myocardial ischemia effect that son hears of electuary of the present invention, can also invigorating QI and tranquilization, just bought 6 courses for the treatment of and taken.
Take embodiment 4 gained invigorating QI and tranquilization electuary, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of.Take 30 days, chest pain, uncomfortable in chestly to alleviate, confusingly in the heart also to alleviate, spirit is very good, takes 5 months, and symptom is eliminated, peace of sleeping night, vexedly removes, and strength increases, and following the service 12 months, does not occur any discomfort when patient takes, and self-induction is fully recovered.
embodiment 5myocardial ischemia warming YANG and invigorating QI electuary, is prepared from primarily of following bulk drugs, is weight portion (every part of 30kg): Concha Ostreae 6, Poria 6, Ramulus Cinnamomi 8, Fructus Hippophae 5, Herba Agerati Conyzoidis 8, Charybdis japonica 4.5, Radix Salviae Miltiorrhizae 7, Mytilus 7, the Radix Stemonae 3.5, the Rhizoma Anemarrhenae 6, Polyporus 9, Rhizoma Alismatis 7, the Radix Astragali 27.
The preparation method of above-mentioned myocardial ischemia warming YANG and invigorating QI electuary is:
(1) juice is decocted in the crude drug put in order mixing, decoct three times altogether, at every turn after water boils, decoct 0.5 hour again, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-2 gram, ethanol (95%) the limit edged adding one times of weight stirs, and precipitates after 15 hours and filters;
(2) filtrate is with thin film evaporation extremely every milliliter of suitable 4.5 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-2 gram, precipitates after 15 hours and filters;
(3) filtrate by thin film evaporation to extractum shape, concentrated solution specific gravity control is 1.0-1.3:1, lets cool to 80 DEG C hereinafter referred to as total solid;
(4) add the white sugar of total solid 2 times of weight, the dextrin of 0.9 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging.
test example 1the clinical practice of embodiment 5 gained treatment myocardial ischemia warming YANG and invigorating QI electuary: in JIUYUE, 2008 in December ,-2013, screens 150 routine Patients with Myocardial Ischemias in 3 second-rank first class hospitals, wherein women 100 example, male 50 example, oldest 85 years old, minimal ages 35 years old, 62 years old mean age.Before test 2 weeks, carry out Continuous Observation to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine (conventional medication such as aspirin, FUFANG DANSHEN PIAN).Using method is: each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of.Curative effect situation criterion: cure: take 3 courses for the treatment of of this product, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take 3 courses for the treatment of of this product, malaise symptoms alleviates or partial disappearance, energy and muscle power strengthen; Invalid: take 3 courses for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 35-75 year myocardial ischemia crowd therapeutic outcome
Therapeutic effect: cure 95 examples (95%), total effective rate 98%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
Take electuary of the present invention 10 days, more than 52% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 50 days, more than 75% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 100 days, more than 98% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and the blood supply of electrocardio diagram coronary artery obviously improves, and some patients self-induction is fully recovered.Take more than 100 days in experimental group, effective percentage can reach more than 93%, and matched group mostly is 80% most, and selected materials is all Chinese medicine material, without any side effects; This prescription meets Chinese medicine principle and cardiac's body and mind feature completely, under the prerequisite of general principle, can have different prescription according to different crowd, and function is different.Medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Claims (2)
1. myocardial ischemia warming YANG and invigorating QI electuary, is characterized in that, is prepared from primarily of following bulk drugs, is weight portion: Concha Ostreae 5, Poria 5, Ramulus Cinnamomi 7, Fructus Hippophae 4, Herba Agerati Conyzoidis 5, Charybdis japonica 4, Radix Salviae Miltiorrhizae 6, Mytilus 6, the Radix Stemonae 3, the Rhizoma Anemarrhenae 5, Rhizoma Alismatis 6, the Radix Astragali 26.
2. the preparation method of myocardial ischemia warming YANG and invigorating QI electuary, is characterized in that, step is as follows:
(1) juice is decocted in the crude drug put in order mixing, decoct three times altogether, at every turn after water boils, decoct 0.4 hour again, filter extracting juice, medicine juice merges, by thin film evaporation to every milliliter contained 1-2 gram, ethanol (95%) the limit edged adding one times of weight stirs, and precipitates after 13 hours and filters;
(2) filtrate is by thin film evaporation to every milliliter of suitable 4.2 grams of crude drugs of medicinal liquid, adds cold water and is diluted to every milliliter contained 1-2 gram, precipitates after 13 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.0-1.3:1, lets cool to 80 DEG C hereinafter referred to as total solid;
(4) add the white sugar of total solid 1.5 times of weight, the dextrin of 0.8 times of weight, with ethanol (65%), regulate humidity, make granule with granulation machine, packaging.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410081919.8A CN103877461A (en) | 2014-03-07 | 2014-03-07 | Yang-warming and qi-benefiting electuary for myocardial ischemia and preparation method thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410081919.8A Division CN103877461A (en) | 2014-03-07 | 2014-03-07 | Yang-warming and qi-benefiting electuary for myocardial ischemia and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105412745A true CN105412745A (en) | 2016-03-23 |
Family
ID=50946797
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510892562.6A Withdrawn CN105396013A (en) | 2014-03-07 | 2014-03-07 | Application of yang-warming and qi-invigorating instant medicine for treating myocardial ischemia in preparing medicine for treating pulmonary heart diseases, myocardial infarction, myocardial necrosis and stenocardia |
| CN201510892564.5A Withdrawn CN105412745A (en) | 2014-03-07 | 2014-03-07 | Yang-warming and qi-tonifying granules for treating myocardial ischemia and preparation method of granules |
| CN201510892662.9A Withdrawn CN105396015A (en) | 2014-03-07 | 2014-03-07 | Preparation method of yang-warming and qi-invigorating instant medicine for treating myocardial ischemia |
| CN201510892663.3A Withdrawn CN105396016A (en) | 2014-03-07 | 2014-03-07 | Yang-warming Qi-benefiting electuary for treating myocardial ischemia |
| CN201410081919.8A Pending CN103877461A (en) | 2014-03-07 | 2014-03-07 | Yang-warming and qi-benefiting electuary for myocardial ischemia and preparation method thereof |
| CN201510892493.9A Withdrawn CN105396012A (en) | 2014-03-07 | 2014-03-07 | Yang warming and qi benefiting electuary for treating myocardial ischemia |
| CN201510892563.0A Withdrawn CN105396014A (en) | 2014-03-07 | 2014-03-07 | Electuary for treating myocardial ischemia |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510892562.6A Withdrawn CN105396013A (en) | 2014-03-07 | 2014-03-07 | Application of yang-warming and qi-invigorating instant medicine for treating myocardial ischemia in preparing medicine for treating pulmonary heart diseases, myocardial infarction, myocardial necrosis and stenocardia |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510892662.9A Withdrawn CN105396015A (en) | 2014-03-07 | 2014-03-07 | Preparation method of yang-warming and qi-invigorating instant medicine for treating myocardial ischemia |
| CN201510892663.3A Withdrawn CN105396016A (en) | 2014-03-07 | 2014-03-07 | Yang-warming Qi-benefiting electuary for treating myocardial ischemia |
| CN201410081919.8A Pending CN103877461A (en) | 2014-03-07 | 2014-03-07 | Yang-warming and qi-benefiting electuary for myocardial ischemia and preparation method thereof |
| CN201510892493.9A Withdrawn CN105396012A (en) | 2014-03-07 | 2014-03-07 | Yang warming and qi benefiting electuary for treating myocardial ischemia |
| CN201510892563.0A Withdrawn CN105396014A (en) | 2014-03-07 | 2014-03-07 | Electuary for treating myocardial ischemia |
Country Status (1)
| Country | Link |
|---|---|
| CN (7) | CN105396013A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101176751A (en) * | 2006-11-09 | 2008-05-14 | 黄振华 | Pharmaceutical composition of red sage root and cassia twig |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101816703A (en) * | 2009-12-09 | 2010-09-01 | 陕西方舟制药有限公司 | Medicinal composition for treating cardiac, cerebral and vascular diseases and preparation method thereof |
-
2014
- 2014-03-07 CN CN201510892562.6A patent/CN105396013A/en not_active Withdrawn
- 2014-03-07 CN CN201510892564.5A patent/CN105412745A/en not_active Withdrawn
- 2014-03-07 CN CN201510892662.9A patent/CN105396015A/en not_active Withdrawn
- 2014-03-07 CN CN201510892663.3A patent/CN105396016A/en not_active Withdrawn
- 2014-03-07 CN CN201410081919.8A patent/CN103877461A/en active Pending
- 2014-03-07 CN CN201510892493.9A patent/CN105396012A/en not_active Withdrawn
- 2014-03-07 CN CN201510892563.0A patent/CN105396014A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101176751A (en) * | 2006-11-09 | 2008-05-14 | 黄振华 | Pharmaceutical composition of red sage root and cassia twig |
Non-Patent Citations (1)
| Title |
|---|
| 栾杰男: ""温阳益心中药预处理对缺血大鼠心肌细胞凋亡的实验研究", 《中国中医药信息杂志》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105396013A (en) | 2016-03-16 |
| CN105396015A (en) | 2016-03-16 |
| CN105396016A (en) | 2016-03-16 |
| CN105396014A (en) | 2016-03-16 |
| CN103877461A (en) | 2014-06-25 |
| CN105396012A (en) | 2016-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103041256B (en) | Chinese herb preparation for curing recurrent respiratory tract infection of children | |
| CN102008674B (en) | Plaster for treating herniated disk, hyperosteogeny and rheumatoid diseases and preparation method thereof | |
| CN104001045A (en) | Drug for treating dog pneumonia and preparation method thereof | |
| CN103845670A (en) | Electuary for treating coronary artery atherosclerosis and preparation method thereof | |
| CN103705733A (en) | Chinese medicine capsule for treating arrhythmia and preparation method thereof | |
| CN103860990B (en) | Coronary heart disease promoting blood circulation to remove obstruction in the collateral powder and preparation method | |
| CN103845671B (en) | Warming YANG and invigorating QI in heart failure falls apart and preparation method | |
| CN104042872B (en) | Traditional Chinese medicine composition for treating common cold of children and preparation method thereof | |
| CN103720870B (en) | Traditional Chinese medicament preparation for treating myocarditis and preparation method thereof | |
| CN105412745A (en) | Yang-warming and qi-tonifying granules for treating myocardial ischemia and preparation method of granules | |
| CN103860991B (en) | Acute heart failure invigorating QI and tranquilization electuary and preparation method | |
| CN105709005A (en) | Breast rehabilitation promoting pill | |
| CN104825883A (en) | Traditional Chinese medicine prescription for treating rhinitis | |
| CN102370848A (en) | Chinese herbal medicine for treating damp evil-caused leucorrhea of women | |
| CN105749086A (en) | Qi invigorating and tranquilization electuary for treating acute heart failure | |
| CN105770649A (en) | Method for preparing qi-invigorating and nerve-calming granules for acute heart failure | |
| CN105709146A (en) | Qi-tonifying nerve-calming electuary for treating acute heart failure | |
| CN109395037A (en) | A kind of Chinese medicine composition and preparation method thereof for treating brain dementia | |
| CN105816765A (en) | Vital energy-replenishing and nerve-calming granules for acute heart failure and preparation method for granules | |
| CN107929473A (en) | A kind of Chinese medicine composition for treating Reflux exophagitis and preparation method thereof | |
| CN107596096A (en) | A kind of medicine for treating influenza and preparation method thereof | |
| CN107802807A (en) | A kind of capsule medicine and preparation method for treating vomiting | |
| CN103860926A (en) | Heat-purging pulvis for treating pulmonary heart disease and preparation method thereof | |
| CN105816830A (en) | Traditional Chinese medicine preparation for treating hypertrophic obstructive cardiomyopathy and preparation method thereof | |
| CN105770545A (en) | Traditional Chinese medicine preparation for treating lung contusions and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 014000 Inner Mongolia Qingshan District, No. 2 National Road, Yingbin District, No. 1, building 1-201, Applicant after: Zhao Yanqing Address before: 250000 Shandong Province, Lixia District, Ji'nan Road, No. 26 liberation Applicant before: Zhao Yanqing |
|
| CB02 | Change of applicant information | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160323 |
|
| WW01 | Invention patent application withdrawn after publication |