CN1840146A

CN1840146A - Medicament for treating vitiligo

Info

Publication number: CN1840146A
Application number: CNA2006100018689A
Authority: CN
Inventors: 王信锁
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-01-25
Filing date: 2006-01-25
Publication date: 2006-10-04
Anticipated expiration: 2026-01-25
Also published as: CN100398143C

Abstract

The invention relates to a Chinese medicinal composition for treating leukodermia, which is prepared from psoralea fruit, ledebouriella root, Tribulus terrestris, dahurian angelica root, atractylodes rhizome, zedoary, peach kernels, safflower, dried rehmannia root, burred tuber, anemarrhena rhizome, oyster shell, corktree bark, sweet wormwood, notoginseng, rhizoma dioscoreae, cicada shell, flavescent sophora root, Chinese dittany bark and bark of boxthron-root.

Description

The leukodermic medicament of a kind of treatment

Technical field

The present invention relates to the leukodermic medicament of a kind of treatment, is that the various vitiligo of a kind of main treatment are the Chinese patent medicine of raw material with the Chinese herbal medicine.

Background technology

Vitiligo is a kind of commonly encountered diseases, and the traditional Chinese medical science is called " vitiligo " again, clinical manifestation be occur on the skin single or multiplely differing in size, pure white speckle that shape differs, later area enlarges gradually, number increases gradually.The boundary of white speckle is clear, and white speckle internal hair is sent out also white, can have pigment not disappear in the white sometimes speckle or island shape point that pigment increases.The patient except that feel indecency, do not have any subjective symptoms.Doctor trained in Western medicine can not be explained etiopathogenesis, and the traditional Chinese medical science is thought and attacked table or wind syndrome due to blood-deficiency so that disorder of QI and blood, blood do not become skin to form by rheumatism.Current, treatment vitiligo Western medicine commonly used, these Western medicine not only cost an arm and a leg, and toxic and side effects is also higher, it is the work of always studying that vitiligo is treated in utilization Chinese herbal treatment or auxiliary smelting, but present medicine can not effect a radical cure, and curative effect can not be satisfactory as " vitiligo sheet " the white speckle enlarged areas that can only tentatively slow down.

Summary of the invention

The purpose of this invention is to provide the leukodermic medicament of a kind of treatment, can treat and effect a radical cure vitiligo, and other dermatosis is also had better curative effect.

Solution of the present invention is according to the rule of the traditional Chinese medical science to therapy of vitiligo, be the body resistance strengthening and constitution consolidating, the kidney invigorating collateral dredging, blood circulation promoting and blood stasis dispelling, the detoxifcation pain relieving, hard masses softening and resolving and dampness removing fluid-purging therapy, the present invention forms according to above-mentioned rule, can the kidney invigorating collateral dredging, blood circulation promoting and blood stasis dispelling, the detoxifcation pain relieving again can the body resistance strengthening and constitution consolidating, hard masses softening and resolving.Rhizoma sparganic of the present invention, Cicadae Slough and Concha Ostreae warming the meridian and promoting blood circulation, hard masses softening and resolving; Cortex Dictamni, Radix Notoginseng, Cortex Phellodendri and Radix Angelicae Dahuricae wind-damp dispelling, dampness is stimulated the menstrual flow, and removing blood stasis with potent drugs is by blood, and the long-pending painful abdominal mass that disappears of mill is subsided a swelling and is restrained; Fructus Psoraleae, Radix Rehmanniae, Fructus Tribuli and Rhizoma Dioscoreae invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating, strong waist knee joint, removing blood stasis with potent drugs is by blood; Flos Carthami, Rhizoma Curcumae, Radix Sophorae Flavescentis and Semen Persicae promoting blood circulation and breaking stagnation, inducing menstruation to relieve menalgia, detumescence and apocenosis, eliminating blood stasis to promote regeneration of blood; Cortex Lycii and Radix Saposhnikoviae warming spleen and stomach for dispelling cold, analgesia, Shujin, suppressing the hyperactive liver and easing the stomach; The Rhizoma Atractylodis expelling pathogenic wind and eliminating dampness, promoting blood circulation and stopping pain, granulation promoting evacuation of pus; Herba Artemisiae Annuae and Rhizoma Anemarrhenae clearing away heat and relieving spasm, blood pressure lowering Dingchuan, diuresis detoxifcation; Have eliminating evil just the wound, set upright and do not stay heresy, the kidney invigorating collateral dredging, warm network blood-activating analgetic, hard masses softening and resolving makes the skin-nourishing abundance, and white speckle inner blood is changed, and impels the matter reparation, has the sick effect of good radical cure.The present invention is monarch with the principles of formulating prescriptions of the traditional Chinese medical science " monarch " with Fructus Psoraleae, Fructus Tribuli, Radix Saposhnikoviae, the Radix Angelicae Dahuricae and Rhizoma Atractylodis; Rhizoma sparganic, Rhizoma Curcumae, Semen Persicae, Flos Carthami, Radix Rehmanniae, the Rhizoma Anemarrhenae, Herba Artemisiae Annuae, Cortex Lycii, Cortex Phellodendri, Cortex Dictamni, Radix Sophorae Flavescentis and Cicadae Slough are minister; Radix Notoginseng, Rhizoma Dioscoreae, Concha Ostreae are assistant; Can treat and effect a radical cure vitiligo.

The present invention is made by the following weight proportion raw material:

112～128 parts of 52～68 portions of Fructus Tribulis of 112～128 parts of Radix Saposhnikoviaes of Fructus Psoraleae

25～35 parts of 52～68 parts of Rhizoma Curcumae of 52～68 parts of Rhizoma Atractylodis of the Radix Angelicae Dahuricae

52～68 parts of 25～35 portions of Radix Rehmanniaes of 25～35 parts of Flos Carthamis of Semen Persicae

52～68 parts of 52～68 portions of Concha Ostreaes of 25～35 parts of Rhizoma Anemarrhenaes of rhizoma sparganic

12～18 parts of 25～35 portions of Radix Notoginseng of 25～35 portions of Herba Artemisiae Annuaes of Cortex Phellodendri

25～35 parts of 12～18 parts of Radix Sophorae Flavescentiss of 25～35 parts of Cicadae Slough of Rhizoma Dioscoreae

25～35 parts of 25～35 parts of Cortex Lycii of Cortex Dictamni.

The weight proportion of each raw material of formula optimization of the present invention is:

116～122 parts of 56～64 portions of Fructus Tribulis of 116～122 parts of Radix Saposhnikoviaes of Fructus Psoraleae

27～33 parts of 56～64 parts of Rhizoma Curcumae of 56～64 parts of Rhizoma Atractylodis of the Radix Angelicae Dahuricae

56～64 parts of 27～33 portions of Radix Rehmanniaes of 27～33 parts of Flos Carthamis of Semen Persicae

56～64 parts of 56～64 portions of Concha Ostreaes of 27～33 parts of Rhizoma Anemarrhenaes of rhizoma sparganic

13～17 parts of 27～33 portions of Radix Notoginseng of 27～33 portions of Herba Artemisiae Annuaes of Cortex Phellodendri

27～33 parts of 13～17 parts of Radix Sophorae Flavescentiss of 27～33 parts of Cicadae Slough of Rhizoma Dioscoreae

27～33 parts of 27～33 parts of Cortex Lycii of Cortex Dictamni.

The weight proportion of best each raw material of prescription of the present invention is:

120 parts of 60 portions of Fructus Tribulis of 120 parts of Radix Saposhnikoviaes of Fructus Psoraleae

30 parts of 60 parts of Rhizoma Curcumae of 60 parts of Rhizoma Atractylodis of the Radix Angelicae Dahuricae

60 parts of 30 portions of Radix Rehmanniaes of 30 parts of Flos Carthamis of Semen Persicae

60 parts of 60 portions of Concha Ostreaes of 30 parts of Rhizoma Anemarrhenaes of rhizoma sparganic

15 parts of 30 portions of Radix Notoginseng of 30 portions of Herba Artemisiae Annuaes of Cortex Phellodendri

30 parts of 15 parts of Radix Sophorae Flavescentiss of 30 parts of Cicadae Slough of Rhizoma Dioscoreae

30 parts of 30 parts of Cortex Lycii of Cortex Dictamni.

The present invention can be made into capsule, is called " compound recipe root of Dahurian angelica white glues capsule " or " compound recipe ends the white glues capsule ".Method for making is to get Concha Ostreae earlier, Radix Sophorae Flavescentis, Radix Notoginseng, Rhizoma Dioscoreae, Cicadae Slough and Fructus Psoraleae drying and crushing to 120～200 order fine powders, get Radix Saposhnikoviae again, Fructus Tribuli, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Curcumae, Semen Persicae, Flos Carthami, Radix Rehmanniae, rhizoma sparganic, the Rhizoma Anemarrhenae, Cortex Phellodendri, Herba Artemisiae Annuae, Cortex Dictamni and Cortex Lycii decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill the leaching supernatant 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and Concha Ostreae, Radix Sophorae Flavescentis, Radix Notoginseng, Rhizoma Dioscoreae, Cicadae Slough and Fructus Psoraleae fine powder mixing, drying, be ground into fine powder, incapsulate.Every adorn 0.3 the gram, oral usually, one time 2～3, a twice-daily.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment vitiligo of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity test underproof animal end sees any toxic reaction, its main organs does not have tangible change yet, and mice is 40g crude drug/kg to the maximum tolerated dose of medicine of the present invention, is 150 times of clinical people's consumption, and safety of medicine is reliable.

2, the present invention need not decoct, no bitterness sense, rich in proteins, volatile oil, starch, glucose, phlegmatic temperament, organic acid, fatty oil, Radix Angelicae Dahuricae element, vitamin and nearly tens seed amino acids in the medicine, also contain various trace elements such as potassium, zinc, calcium, ferrum, be beneficial to absorption of human body, health invigorating, and taking convenience.

3, the present invention can treat and effect a radical cure vitiligo effectively, and other scytitis is also had the effect of better curative effect function, has improved patient's life quality and the time greatly, and higher healing rehabilitation efficacy is arranged.

For showing medicine of the present invention, as follows through clinical test results to leukodermic therapeutic effect; Treat various patients with vitiligo 50 examples, radical cure rehabilitation 40 examples, produce effects 3 examples, effective 5 examples, invalid 2 examples, effective percentage reaches more than 96%.Treat other scytitis (as eczema, dermatitis etc.) 40 examples, radical cure rehabilitation 17 examples, produce effects 10 examples, effective 8 examples, invalid 5 examples, effective percentage reaches more than 87%.

The specific embodiment

Take by weighing raw material by following proportioning: Fructus Psoraleae 120g, Radix Saposhnikoviae 60g, Fructus Tribuli 120g, Radix Angelicae Dahuricae 60g, Rhizoma Atractylodis 60g, Rhizoma Curcumae 30g, Semen Persicae 30g, Flos Carthami 30g, Radix Rehmanniae 60g rhizoma sparganic 30g, Rhizoma Anemarrhenae 60g, Concha Ostreae 60g, Cortex Phellodendri 30g, Herba Artemisiae Annuae 30g, Radix Notoginseng 15g, Rhizoma Dioscoreae 30g, Cicadae Slough 15g, Radix Sophorae Flavescentis 30g, Cortex Dictamni 30g, Cortex Lycii 30g.

Production method is as follows: get Concha Ostreae earlier, Radix Sophorae Flavescentis, Radix Notoginseng, Rhizoma Dioscoreae, Cicadae Slough and Fructus Psoraleae drying and crushing to 120～200 order fine powders, get Radix Saposhnikoviae again, Fructus Tribuli, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Curcumae, Semen Persicae, Flos Carthami, Radix Rehmanniae, rhizoma sparganic, the Rhizoma Anemarrhenae, Cortex Phellodendri, Herba Artemisiae Annuae, Cortex Dictamni and Cortex Lycii decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, the leaching supernatant, reclaim ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and Concha Ostreae, Radix Sophorae Flavescentis, Radix Notoginseng, Rhizoma Dioscoreae, Cicadae Slough and Fructus Psoraleae fine powder mixing, dry, be ground into powder, or fine powder, incapsulate.Every adorn 0.3 the gram, oral usually, one time 2～3, a twice-daily.

Claims

1, the leukodermic medicament of a kind of treatment is characterized in that it is made by the following weight proportion raw material:

25～35 parts of 25～35 parts of Cortex Lycii of Cortex Dictamni.

2, the leukodermic medicament of a kind of treatment according to claim 1, wherein the weight proportion of each raw material is:

27～33 parts of 27～33 parts of Cortex Lycii of Cortex Dictamni.

3, the leukodermic medicament of a kind of treatment according to claim 1, wherein the weight proportion of each raw material is:

30 parts of 30 parts of Cortex Lycii of Cortex Dictamni.