CN100435833C - Medicine for treating Bi syndrome and method for preparing same - Google Patents

Medicine for treating Bi syndrome and method for preparing same Download PDF

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CN100435833C
CN100435833C CNB2006100177914A CN200610017791A CN100435833C CN 100435833 C CN100435833 C CN 100435833C CN B2006100177914 A CNB2006100177914 A CN B2006100177914A CN 200610017791 A CN200610017791 A CN 200610017791A CN 100435833 C CN100435833 C CN 100435833C
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radix
herba
medicine
fructus
radix angelicae
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CN1879817A (en
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陈法成
陈晓伟
郭贞玉
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Abstract

The present invention discloses a medicine for treating arthralgia syndrome, and a preparation method thereof. The medicine is prepared from the traditional Chinese medicines of eucommia bark, Radix Dipsaci from Sichuan of China, epimedium herb, angelica, fleeceflower root, Chinese taxillus twig, cibot rhizome, dendrobium, etc. which are prepared by the techniques of sieving, preparing into granules, drying and sterilization packaging. Compared with the existing medicines for treating arthralgia syndrome, the present invention has the functions of antipyretia, analgesia, inflammation, elimination of swelling, improvement of the microcirculatory and increase of the immunity and cold-resistance of organisms. The present invention is used for treating rheumatic arthralgia, particularly for treating symptoms of pain in the limbs, etc. caused by prolapse of lumbar intervertebral disc.

Description

Medicine of treatment arthromyodynia and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of arthromyodynia, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Arthromyodynia (doctor trained in Western medicine is diseases such as intervertebral disk hernia, cervical spondylosis, rheumatism, rheumatoid) is human a kind of disease, particularly keep a kind of people (as driver, computer operator, teacher etc.) morbidity risk rate of posture high often, caused very big misery to people to some.And this disease is difficult to cure, even if the also just temporary transient pain of removing of operative treatment (extracing vertebral pulp, releasing compressing), relapse rate is high, and the patient of adaptation operation disease only accounts for about 5% of clinical all cases.
And most of people that got arthromyodynia usually are with some Western medicine analgesic, and traction massage therapeutic has perhaps been taken some other Chinese medicine such as YAOTONGNING etc.If but these drug mains are partial to analgesic antiphlogistic, and to the adjustment of human body integral internal medium, the no effects such as raising of whole immunologic mechanism, therefore temporary transient pain relieving can not stop the continuation regression of intervertebral disc, and the performance of intervertebral disc is improved in more impossible aspect of becoming better.Existing medicine (or operation etc.) treatment arthromyodynia exists to be controlled table and does not effect a permanent cure, can only pain relieving, and the deficiency that can not cure the disease, and usually oral analgesic causes very macrolesion to people's health.
The object of the present invention is to provide a kind of pure Chinese medicinal preparation for the treatment of arthromyodynia, be used for the limbs pain that rheumatic Bi syndrome causes, can not only reducing swelling and alleviating pain, and also by microcirculation improvement, human body immunity improving resisting cold ability, thus reach treating both the principal and secondary aspects of a disease.
Another object of the present invention provides a kind of preparation method of this arthromyodynia medicine.
The raw material medicaments in part by weight of medicine of the present invention is: Cortex Eucommiae 6-9, Radix Dipsaci 6-9, Herba Epimedii 3.6-5, Radix Angelicae Sinensis 8-12, Radix Polygoni Multiflori 5-7, Herba Taxilli 5-7, Rhizoma Cibotii 4-6, Herba Dendrobii 2.4-4, Herba Ephedrae 6.8-16, Ramulus Cinnamomi 3-4, Radix Astragali 3-4, Radix Glycyrrhizae 3-3.6, Radix Clematidis 3-6, Fructus Liquidambaris 2-3, Radix Angelicae Pubescentis 2-6, Radix Salviae Miltiorrhizae 1.6-3, Rhizoma Chuanxiong 3-5, Herba Leonuri 3-5, Radix Cyathulae 3-5, Fructus Crataegi 1-3, Fructus Hordei Germinatus 1-3.
The best proportioning of the raw material medicaments in part by weight of medicine of the present invention:
The Cortex Eucommiae 7, Radix Dipsaci 7, Herba Epimedii 4, Radix Angelicae Sinensis 10, Radix Polygoni Multiflori 6, Herba Taxilli 6, Rhizoma Cibotii 5, Herba Dendrobii 3, Herba Ephedrae 12, Ramulus Cinnamomi 3.6, the Radix Astragali 3.6, Radix Glycyrrhizae 3.2, Radix Clematidis 4, Fructus Liquidambaris 2.6, Radix Angelicae Pubescentis 4, Radix Salviae Miltiorrhizae 2, Rhizoma Chuanxiong 4, Herba Leonuri 4, Radix Cyathulae 4, Fructus Crataegi 2, Fructus Hordei Germinatus 2.
Above-mentioned each component is made medicine production method of the present invention is:
1, screening do not have go mouldy, free from insect pests, the pure Cortex Eucommiae of color and luster, Radix Dipsaci, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Herba Taxilli, Rhizoma Cibotii, Herba Dendrobii, Herba Ephedrae, Ramulus Cinnamomi, the Radix Astragali, Radix Glycyrrhizae, Radix Clematidis, Fructus Liquidambaris, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Radix Cyathulae, Fructus Crataegi, Fructus Hordei Germinatus cleans respectively, oven dry, bake out temperature is 60-80 ℃, is crushed to the above fine powder of 100 mesh sieves, packing is standby;
2, the allotment Cortex Eucommiae, Radix Dipsaci, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Herba Taxilli, Rhizoma Cibotii, Herba Dendrobii, Herba Ephedrae, Ramulus Cinnamomi, the Radix Astragali, Radix Glycyrrhizae, Radix Clematidis, Fructus Liquidambaris, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Radix Cyathulae, Fructus Crataegi, Fructus Hordei Germinatus fine powder mixing, bitter in the mouth suffering, little sweet, no exogenous impurity;
3, granulation all by No. 6 dusting covers, adds Mel with above-mentioned all fine powders, and maltodextrin mixes the suitable plasticity powder agglomates of humidity, and tack-free, not loose, humidity is suitable, inserts full automatic machine for producing pills, makes the even pill of size;
4, oven dry, sterilization are placed the pill that makes in the drying baker, and temperature is controlled at 60-80 ℃, dries 24 hours; Cell proliferation body is wherein killed, at room temperature placed then 24 hours, allow spore wherein develop into brood body, heat 60-80 ℃ for the second time again, dried 24 hours, it is killed, heating and placement continued operation can all be eliminated its brood cell more than three times;
5, packing will meet the plastic drug package ultraviolet radiation sterilization of national standard, the sterilized pill of quantitatively packing in clean room.
Solution of the present invention is based on motherland's medical science to pathogenetic understanding of arthromyodynia and Therapeutic Principle, with reference to the modern pharmacological research achievement, filters out from motherland's medicine treasure-house.The pathogeny of primary disease (traditional Chinese medical science) is because inertia strains, and traumatic injury is worn with age, or the natural endowment deficiency, causes the positive QI-insufficiency of plain body, and caused by liver and kidney deficiency is affected by the cold, and wet, evil, heresy is stopped sun urinary bladder channel, the Gallbladder Channel of Foot-Shaoyang.Make this two through coagulation of QI-blood, passages through which vital energy circulates is obstructed, walk muscle arteries and veins contracture pain so cause bladder meridian, the Gallbladder Channel of Foot-Shaoyang, numbness unbearably, severe patient causes gatism, quadriplegia, QI and blood at mediation bladder meridian, the Gallbladder Channel of Foot-Shaoyang, improving its microcirculation, the inside of human body environment is improved, is the basic place of treatment numbness disease.
This medicine of the present invention is owing to selected the Cortex Eucommiae for use, Radix Dipsaci, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Herba Taxilli, Rhizoma Cibotii, Herba Dendrobii be as monarch drug, wherein the Cortex Eucommiae: have invigorating the liver and kidney, the effect of bone and muscle strengthening, be usually used in the waist and knee due to the Liver and kidney weakness, can invigorating the liver and kidney, bone and muscle strengthening has certain analgesic activity again.Radix Dipsaci: this product can be taken a tonic or nourishing food to build up one's health Liver and kidney and strong muscles and bones, again can promoting blood circulation, so be usually used in deficiency of the liver and kindey, and the lumbocrural pain due to blood vessels are smooth, rheumatism numbness disease.Herba Epimedii: have kidney invigorating and YANG supporting, strengthening the tendons and bones, the effect of expelling wind and removing dampness is used for rheumatic arthralgia, numb limbs and tense tendons, contracture, or doublely see that the muscles and bones flaccidity is soft, diseases such as lower extremity paralysis contain icariine, flavonoid glycoside, and contain sterol, alkaloid, volatile oil, vitamin E etc.Radix Angelicae Sinensis: have tonifying blood and regulating menstruation, the effect of promoting blood circulation and stopping pain is the hematonic of using always.The promoting blood circulation and stopping pain effect is applicable to traumatic injury, and rheumatic arthralgia can be enriched blood, and can invigorate blood circulation pain relieving again.Contain volatile oil, folinic acid, nicotinic acid, sucrose, cupreol, vitamin B 12Deng, calmness, analgesia and antiinflammation are arranged.Herba Taxilli: be used for the rheumatic arthralgia person that has the caused by liver and kidney deficiency concurrently, disease is seen lumbocrural pain, and the muscles and bones flaccidity is soft.This product gets final product wind-damp dispelling, and Shujin network and sharp joint can invigorating the liver and kidney, bone and muscle strengthening, and strengthen resistance against diseases.Rhizoma Cibotii: this product has invigorating the liver and kidney, strong waist knee joint effect, is applicable to rheumatism with the passing of time, pain along the spinal column, diseases such as the foot and knee being feeble.Herba Dendrobii: this product reinforcing stomach reg fluid and clear asthenic fire, have concurrently simultaneously separate ripe, the analgesic effect.Radix Polygoni Multiflori: have invigorating the liver and kidney, the effect of benefiting essence-blood detoxifcation.Be applicable to Liver and kidney two void, the soft grade of waist knee joint flaccidity disease.More than 8 flavor monarchs drug take same-action and go into liver, kidney two warps, the efficacy of a drug multiplication of invigorating the liver and kidney behind all key medicine compatibilities, benefiting essence-blood, and tonify without causing stagnation take into account negative and positive.
Owing to selected Herba Ephedrae for use, Ramulus Cinnamomi, the Radix Astragali, Radix Glycyrrhizae is as ministerial drug, its epheday intermedia: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Ramulus Cinnamomi: be used for the evil arthralgia of invading due to the meridians of wind and cold, temperature three-way meridian arranged, the effect of wind-damp dispelling.The Radix Astragali: can tonification defend outer yang-energy and strengthening superficial resistance to stop perspiration.Radix Glycyrrhizae: invigorating the spleen and replenishing QI, alleviate pain relieving, coordinating the actions of various ingredients in a prescription.Herba Ephedrae, Ramulus Cinnamomi diaphoresis with drugs pungent in flavor and warm in nature are induced sweat, and the logical extremity passages through which vital energy circulates of temperature is trembled with fear and stagnated, and arrogate to oneself especially and walk urinary bladder channel, so can alleviate lower limb pain, and the Radix Astragali, the Radix Glycyrrhizae benefiting QI for strengthening the superficies, two medicine compatibilities are mended eliminating stagnation and are closed, and the heresy of table reality is then crossed high by unlikely diaphoresis and is defended sun not admittedly.
Radix Clematidis, Fructus Liquidambaris, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Radix Cyathulae is as adjuvant drug, wherein Radix Clematidis: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Be used for rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, the bone larynx of choking with sobs.Fructus Liquidambaris: be used for rheumatic arthralgia, podomere numbness, cards such as spasm of the limbs.Radix Angelicae Pubescentis: be used for rheumatic arthralgia, the effect of diffusing wind prevailing over dampness eliminating impediment pain relieving is arranged, be suitable for wet relatively lower limb especially.Radix Salviae Miltiorrhizae: this product passive stasis of blood of invigorating blood circulation, can be used for the disease of multiple blood stasis for suffering from, to the pain due to the blood stasis, this product has good analgesic effect.Rhizoma Chuanxiong: this product is used for acute and chronic muscle, the nerve injury due to the blood stagnation stagnation of QI, can not only promoting blood circulation and stopping pain, and may sharp blood vessels, the effect of activating blood circulation and unblocking obstruction is still arranged.Herba Leonuri: this product is arrogated to oneself blood stasis especially and is had a pain, and eliminates edema.Radix Cyathulae: the invigorating the liver and kidney of this product energy, bone and muscle strengthening, sharp joint is longer than and is controled the inferior the half body waist gonalgia.
But above medicine is taken with the expelling wind and removing dampness promoting blood circulation and stopping pain.Because above Chinese medicine is warm product, is configured to Fructus Crataegi, Fructus Hordei Germinatus again, is used for the spleen and stomach regulating, to alleviate gastrointestinal irritation.
This prescription is through development test for many years, and thinking is rigorous, and allotment rationally.Therefore in to 1000 many cases arthromyodynias (particularly prolapse of lumbar intervertebral disc) treatment, obtained better curative effect.The smelting rate of healing can reach 80%, and effective percentage can reach 98%.This medicine can improve body immunity, replenish multiplely support one's family, various trace elements, several amino acids, but microcirculation improvement, the human internal environment is improved, thereby can reach strong physique, but and antipyretic-antalgic, anti-inflammation detumescence, improve the effect of local blood circulation, by improving the oppressed nerve root or the microcirculation of dural sac, the antiinflammatory dehydration absorbs the aseptic inflammation of lesion, remove adhesion, make outstanding nucleus pulposus dehydration fibroatrophy, remove stimulation, reach the purpose of treatment nerve root and dural sac.
This Chinese medicine is evident in efficacy in clinical practice, as:
Lee, the man, 52 years old, poplar building, Fangcheng County, Nanyang village people begins pain in the lumbar region in August, 2002, through local doctor's traction massage, after treatment measures such as oral Chinese medicine and western medicine are invalid, being CT to county hospital is diagnosed as: prolapse of lumbar intervertebral disc, and the patient had developed into whole piece lower limb numbness at that time, pain, can't take care of oneself, after others makes referrals to my institute's treatment, the medicine of oral this treatment arthromyodynia three months, thoroughly cure, the 25th day patient that take medicine promptly feels pain relief, can directly play back, be almost recovered in the 50th day, can go to work in the fields, after after treatment one month again, not recurrence so far.
Zhang, woman, 55 years old, area just outside a city gate, Xixia County people from town suffered from prolapse of lumbar intervertebral disc in 93 years, treated 2 years, go around the Nanyang various big hospital, the state of an illness repeatedly, the time heavy when light, after the disappointment, go to operation, but the patient there are diabetes, operation risk is bigger, introduces through other patients, begins to take after 45 days patient's symptom and alleviates to some extent, recovery from illness in 4 months, not recurrence so far.
Guo, the man, 79 years old, the retired veteran cadre of Nanyang power administration institute treated prolapse of lumbar intervertebral disc in July, 2002 to me, the patient had my old man to assist at that time, can not walk the main suit alone: pain in the lumbar region, lower limb numbness, edema of lower limbs 8 months begins to have Western medicine to city hospital transfusion, beat seal all invalid.Other have been cured the patient and have made referrals to my institute's treatment, recovery from illness in oral 4 months to listen the court.Because the old the moon of patient loses, to obey so allow it hold concurrently, period in a medicine has no adverse reaction.
Following table is this medicine of the present invention and existing comparison sheet for the treatment of arthromyodynia medicine, method:
Figure C20061001779100091
The specific embodiment
The raw material medicaments in part by weight of embodiment 1 preparation medicine of the present invention is:
Cortex Eucommiae 6-9, Radix Dipsaci 6-9, Herba Epimedii 3.6-5, Radix Angelicae Sinensis 8-12, Radix Polygoni Multiflori 5-7, Herba Taxilli 5-7, Rhizoma Cibotii 4-6, Herba Dendrobii 2.4-4, Herba Ephedrae 6.8-16, Ramulus Cinnamomi 3-4, Radix Astragali 3-4, Radix Glycyrrhizae 3-3.6, Radix Clematidis 3-6, Fructus Liquidambaris 2-3, Radix Angelicae Pubescentis 2-6, Radix Salviae Miltiorrhizae 1.6-3, Rhizoma Chuanxiong 3-5, Herba Leonuri 3-5, Radix Cyathulae 3-5, Fructus Crataegi 1-3, Fructus Hordei Germinatus 1-3.
The raw material medicaments in part by weight of embodiment 2 preparations medicine of the present invention is:
The Cortex Eucommiae 6, Radix Dipsaci 6, Herba Epimedii 3.6, Radix Angelicae Sinensis 8, Radix Polygoni Multiflori 5, Herba Taxilli 5, Rhizoma Cibotii 4, Herba Dendrobii 2.4, Herba Ephedrae 6.8, Ramulus Cinnamomi 3, the Radix Astragali 3, Radix Glycyrrhizae 3, Radix Clematidis 3, Fructus Liquidambaris 2, Radix Angelicae Pubescentis 2, Radix Salviae Miltiorrhizae 1.6, Rhizoma Chuanxiong 3, Herba Leonuri 3, Radix Cyathulae 3, Fructus Crataegi 1, Fructus Hordei Germinatus 1.
The raw material medicaments in part by weight of embodiment 3 preparations medicine of the present invention is:
The Cortex Eucommiae 9, Radix Dipsaci 9, Herba Epimedii 5, Radix Angelicae Sinensis 12, Radix Polygoni Multiflori 7, Herba Taxilli 7, Rhizoma Cibotii 6, Herba Dendrobii 4, Herba Ephedrae 16, Ramulus Cinnamomi 4, the Radix Astragali 4, Radix Glycyrrhizae 3.6, Radix Clematidis 6, Fructus Liquidambaris 3, Radix Angelicae Pubescentis 6, Radix Salviae Miltiorrhizae 3, Rhizoma Chuanxiong 5, Herba Leonuri 5, Radix Cyathulae 5, Fructus Crataegi 3, Fructus Hordei Germinatus 3.
The raw material medicaments in part by weight optimum ratio of embodiment 4 preparations medicine of the present invention is:
The Cortex Eucommiae 7, Radix Dipsaci 7, Herba Epimedii 4, Radix Angelicae Sinensis 10, Radix Polygoni Multiflori 6, Herba Taxilli 6, Rhizoma Cibotii 5, Herba Dendrobii 3, Herba Ephedrae 12, Ramulus Cinnamomi 3.6, the Radix Astragali 3.6, Radix Glycyrrhizae 3.2, Radix Clematidis 4, Fructus Liquidambaris 2.6, Radix Angelicae Pubescentis 4, Radix Salviae Miltiorrhizae 2, Rhizoma Chuanxiong 4, Herba Leonuri 4, Radix Cyathulae 4, Fructus Crataegi 2, Fructus Hordei Germinatus 2.
Above-mentioned each component is made medicine production method of the present invention:
1, screening do not have go mouldy, free from insect pests, the pure Cortex Eucommiae of color and luster, Radix Dipsaci, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Herba Taxilli, Rhizoma Cibotii, Herba Dendrobii, Herba Ephedrae, Ramulus Cinnamomi, the Radix Astragali, Radix Glycyrrhizae, Radix Clematidis, Fructus Liquidambaris, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Radix Cyathulae, Fructus Crataegi, Fructus Hordei Germinatus cleans, oven dry, bake out temperature is 60-80 ℃, is crushed to the above fine powder of 100 mesh sieves, packing is standby;
2, the allotment Cortex Eucommiae, Radix Dipsaci, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Herba Taxilli, Rhizoma Cibotii, Herba Dendrobii, Herba Ephedrae, Ramulus Cinnamomi, the Radix Astragali, Radix Glycyrrhizae, Radix Clematidis, Fructus Liquidambaris, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Radix Cyathulae, Fructus Crataegi, Fructus Hordei Germinatus mixing, bitter in the mouth suffering, little sweet, no exogenous impurity;
3, granulation all by No. 6 dusting covers, adds Mel with above-mentioned all fine powders, and maltodextrin mixes the suitable plasticity powder agglomates of humidity, and tack-free, not loose, humidity is suitable, inserts full automatic machine for producing pills, makes the even pill of size;
4, oven dry, sterilization are placed the pill that makes in the drying baker, and temperature is controlled at 60-80 ℃, dries 24 hours; Cell proliferation body is wherein killed, at room temperature placed then 24 hours, allow spore wherein develop into brood body, heat 60-80 ℃ for the second time again, dried 24 hours, it is killed, heating and placement continued operation can all be eliminated its brood cell more than three times;
5, packing will meet the plastic drug package ultraviolet radiation sterilization of national standard, the sterilized pill of quantitatively packing in clean room.

Claims (3)

1, a kind of medicine for the treatment of arthromyodynia is characterized in that the raw material medicaments in part by weight for preparing this medicine is: Cortex Eucommiae 6-9, Radix Dipsaci 6-9, Herba Epimedii 3.6-5, Radix Angelicae Sinensis 8-12, Radix Polygoni Multiflori 5-7, Herba Taxilli 5-7, Rhizoma Cibotii 4-6, Herba Dendrobii 2.4-4, Herba Ephedrae 6.8-16, Ramulus Cinnamomi 3-4, Radix Astragali 3-4, Radix Glycyrrhizae 3-3.6, Radix Clematidis 3-6, Fructus Liquidambaris 2-3, Radix Angelicae Pubescentis 2-6, Radix Salviae Miltiorrhizae 1.6-3, Rhizoma Chuanxiong 3-5, Herba Leonuri 3-5, Radix Cyathulae 3-5, Fructus Crataegi 1-3, Fructus Hordei Germinatus 1-3.
2, the medicine of treatment arthromyodynia according to claim 1 is characterized in that the raw material medicaments in part by weight for preparing this medicine is: the Cortex Eucommiae 7, Radix Dipsaci 7, Herba Epimedii 4, Radix Angelicae Sinensis 10, Radix Polygoni Multiflori 6, Herba Taxilli 6, Rhizoma Cibotii 5, Herba Dendrobii 3, Herba Ephedrae 12, Ramulus Cinnamomi 3.6, the Radix Astragali 3.6, Radix Glycyrrhizae 3.2, Radix Clematidis 4, Fructus Liquidambaris 2.6, Radix Angelicae Pubescentis 4, Radix Salviae Miltiorrhizae 2, Rhizoma Chuanxiong 4, Herba Leonuri 4, Radix Cyathulae 4, Fructus Crataegi 2, Fructus Hordei Germinatus 2.
3, the medicine of treatment arthromyodynia according to claim 1 is characterized in that preparation method is:
1) screening do not have go mouldy, free from insect pests, the pure Cortex Eucommiae of color and luster, Radix Dipsaci, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Herba Taxilli, Rhizoma Cibotii, Herba Dendrobii, Herba Ephedrae, Ramulus Cinnamomi, the Radix Astragali, Radix Glycyrrhizae, Radix Clematidis, Fructus Liquidambaris, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Radix Cyathulae, Fructus Crataegi, Fructus Hordei Germinatus cleans, oven dry, bake out temperature is 60-80 ℃, is crushed to the above fine powder of 100 mesh sieves, packing is standby;
2) the allotment Cortex Eucommiae, Radix Dipsaci, Herba Epimedii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Herba Taxilli, Rhizoma Cibotii, Herba Dendrobii, Herba Ephedrae, Ramulus Cinnamomi, the Radix Astragali, Radix Glycyrrhizae, Radix Clematidis, Fructus Liquidambaris, Radix Angelicae Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Radix Cyathulae, Fructus Crataegi, Fructus Hordei Germinatus mixing, bitter in the mouth suffering, little sweet, no exogenous impurity;
3) granulation all by No. 6 dusting covers, adds Mel with above-mentioned all fine powders, and maltodextrin mixes the suitable plasticity powder agglomates of humidity, and tack-free, not loose, humidity is suitable, inserts full automatic machine for producing pills, makes the even pill of size;
4) oven dry, sterilization are placed the pill that makes in the drying baker, and temperature is controlled at 60-80 ℃, dries 24 hours; Cell proliferation body is wherein killed, at room temperature placed then 24 hours, allow spore wherein develop into brood body, heat 60-80 ℃ for the second time again, dried 24 hours, it is killed, heating and placement continued operation can all be eliminated its brood cell more than three times;
5) packing will meet the plastic drug package ultraviolet radiation sterilization of national standard, the sterilized pill of quantitatively packing in clean room.
CNB2006100177914A 2006-05-11 2006-05-11 Medicine for treating Bi syndrome and method for preparing same Expired - Fee Related CN100435833C (en)

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