CN102526406A - Traditional Chinese medicine plaster for treating cervical spondylotic radiculopathy and preparation method thereof - Google Patents
Traditional Chinese medicine plaster for treating cervical spondylotic radiculopathy and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine plaster for treating cervical spondylotic radiculopathy and a preparation method thereof. The traditional Chinese medicine plaster comprises the following bulk pharmaceutical chemicals in parts by weight: 20-40 parts of astragalus mongholicus, 10-25 parts of angelica sinensis, 15-30 parts of herba epimedii, 5-25 parts of deerhorn glue, 6-20 parts of root of common peony, 6-20 parts of cassia twig, 3-20 parts of dragon's blood, 6-20 parts of lycopodium clavatum, 6-20 parts of mustard, 6-20 parts of pseudo-ginseng, 6-20 parts of red flower, 6-20 parts of frankincense and 3-13 parts of borneol. The traditional Chinese medicine disclosed by the invention can nourish liver and kidney, tonify qi, invigorate the circulation of blood and kill pain, is convenient to apply, has a definite curative effect and has a good effect on treating the cervical spondylosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly a kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy and preparation method thereof.
Background technology
(Cervical spondylotic radiculopathy CSR) is the highest type of sickness rate in the cervical spondylotic radiculopathy to cervical spondylotic radiculopathy, and nearly 60% old people suffered from or just suffering from this disease; Belong to Chinese medicine " BI-syndrome involved the tendon ", " arthralgia due to stagnation of blood " category; Mainly weak, caused by liver and kidney deficiency by plain body, damage of essence can not moisten the nourishing muscle and tendon bone, causes blockage of main and collateral channels; Due to QI-blood circulation is obstructed, so mostly the gerontal patient is " caused by liver and kidney deficiency, qi and blood deficiency " CSR clinically.Yet; The present change that the treatment and the research of old cervical spondylotic radiculopathy are confined to clinical symptoms more; Its etiology and pathogenesis is lacked further investigation, more lack, and late result is imprecise when making clinical treatment to the research of " caused by liver and kidney deficiency, insufficiency of vital energy and blood " type CSR; Apply being subject to many limitations, brought great misery to the gerontal patient.Therefore, how to improve the therapeutic effect of cervical spondylotic radiculopathy, seek that a kind of cost is low, side effect is little, medicine that can life-time service has far-reaching social meaning, also is the medical circle problem demanding prompt solution.
Treatment " caused by liver and kidney deficiency, qi and blood deficiency " CSR does not have exclusive medicine as yet at present, mostly tends to the change of clinical symptoms, and the data of relevant physical and chemical index, physics and terms of mechanics then quite lack.Chinese medicine has treatment by oral administration of medicines, external treatment, interior external treatment in treatment on this disease, and the external treatment rule is a kind ofly to start with, take into account the method for effecting a permanent cure from mark.Mostly the Chinese medicine for external application that occurs at present is to rest on rubber plaster, black plaster level, and dosage form falls behind, and consumption is big, uses inconveniently, and effect is not good enough, thus develop evident in efficacy, lasting, carry and use all easily that external preparation becomes the new breakthrough mouth.The cervicodynia paster that relaxes is the externally applied transdermal patch that effective ingredient and polymeric membrane material employing bonding mode are combined into; Action time can be prolonged; Keep constant blood drug level; And have that drug loading is big, advantage such as good permeability, bioavailability be high, and zest is little, development and application has a extensive future.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy and preparation method thereof, the invigorating the liver and kidney of this kind Chinese medicine ability, benefiting QI for activating blood circulation pain relieving.Chinese medicine of the present invention is easy to use, drug effect is definite, therapeutic effect is good.
The technical scheme that the present invention takes is:
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: Radix Astragali 20-40 part, Radix Angelicae Sinensis 10-25 part, Herba Epimedii 15-30 part, Colla cornus cervi 5-25 part, Radix Paeoniae Rubra 6-20 part, Ramulus Cinnamomi 6-20 part, Sanguis Draxonis 3-20 part, Herba Lycopodii 6-20 part, Semen Sinapis 6-20 part, Radix Notoginseng 6-20 part, Flos Carthami 6-20 part, Olibanum 6-20 part and Borneolum Syntheticum 3-13 part.
The Chinese medicine plaster of above-mentioned treatment cervical spondylotic radiculopathy, the weight part ratio composition of its crude drug is preferably: Radix Astragali 25-33 part, Radix Angelicae Sinensis 12-18 part, Herba Epimedii 15-25 part, Colla cornus cervi 10-18 part, Radix Paeoniae Rubra 8-12 part, Ramulus Cinnamomi 8-12 part, Sanguis Draxonis 8-12 part, Herba Lycopodii 8-12 part, Semen Sinapis 8-12 part, Radix Notoginseng 8-12 part, Flos Carthami 8-12 part, Olibanum 8-12 part and Borneolum Syntheticum 6-12 part.
The Chinese medicine plaster of above-mentioned treatment cervical spondylotic radiculopathy, the weight part ratio of its crude drug are formed and further are preferably: 10 parts of 30 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts of Herba Epimedii, 15 parts of Colla cornus cervis, 10 parts of Radix Paeoniae Rubra, 10 parts of Ramulus Cinnamomi, 10 parts of Sanguis Draxonis, 10 parts of Herba Lycopodiis, 10 parts in Semen Sinapis, 10 parts of Radix Notoginseng, 10 parts on Flos Carthami, 10 parts of Olibanums and Borneolum Syntheticums.
The method for preparing of the Chinese medicine plaster of described treatment cervical spondylotic radiculopathy comprises the steps:
(1) Sanguis Draxonis, Borneolum Syntheticum pulverize separately are become fine powder, subsequent use;
(2) Colla cornus cervi crushing and water-adding molten is become Colla cornus cervi cream, subsequent use;
(3) Radix Notoginseng is pulverized and adds ethanol extraction, filters, and reclaims ethanol, and is condensed into Radix Notoginseng alcohol extraction condensed cream, and is subsequent use;
(4) with Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation volatile oil, volatile oil is subsequent use, and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues are merged; Decocte with water; Filter, merge into decocting liquid, decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil; And be condensed into water drug-decocting concentrating liquid, subsequent use;
(6) (5) water drug-decocting concentrating liquid is added ethanol and stir, leave standstill, deposition filters, and filtrate recycling ethanol also is condensed into the water decoction-alcohol sedimentation concentrated extract, and is subsequent use;
(7) volatile oil with Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream, water decoction-alcohol sedimentation condensed cream and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is mixed into medicament mixed cream; Again with itself and Percutaneous absorption enhancer, pressure sensitive adhesive, other macromolecular material mixing; Coating; Drying adds protective layer.
The preparation method of Chinese medicine of above-mentioned treatment cervical spondylotic radiculopathy:
Fine powder described in the step (1) is crossed No. five sieves (80 order).
Colla cornus cervi is pulverized the back and is crossed a sieve (10 order) in the step (2), adds its quality 2-6 water doubly, and Colla cornus cervi cream relative density is 1.02-1.35 (50-80 a ℃).
In the step (3) Radix Notoginseng was pulverized a sieve (10 order); Alcohol reflux 2-4 time adds the ethanol of Radix Notoginseng quality 5-15 60%-85% (V/V) doubly at every turn, refluxes 0.5-3 hour at every turn; Filter; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.05-1.35 (50-80 a ℃).
In the step (4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added its quality 3-8 water doubly, vapor distillation extracts volatile oil, and the time of extracting volatile oil is 4-10 hour.
The described decoction of step (5) 2-4 time, each water that adds the total dry mass 4-15 of the medicine that decocts times of institute decocted 0.5-3 hour at every turn, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.05-1.35 (50-80 ℃).
The described ethanol of step (6) is with 95% (V/V), and consumption is for mixing the 50-75% (m/m) of back material mass, and being concentrated into relative density is the water decoction-alcohol sedimentation concentrated extract of 115-1.35 (50-80 ℃).
1.25-1.35 when the described medicament mixed cream of step (7) relative density is preferably 50-80 ℃; Described Percutaneous absorption enhancer is preferably propylene glycol and azone; Pressure sensitive adhesive is preferably acrylate pressure-sensitive adhesive, and macromolecular material is preferably acrylic resin and polyvinylpyrrolidone.The propylene glycol consumption is the 2-10% (m/m) of medicament mixed cream quality; The azone consumption is the 1-5% (m/m) of medicament mixed cream quality; The acrylate pressure-sensitive adhesive consumption is the 55-75% (m/m) of medicament mixed cream quality; The acrylic resin consumption is the 3-10% (m/m) of medicament mixed cream quality, and the polyvinylpyrrolidone consumption is the 3-10% (m/m) of medicament mixed cream quality.The every 100cm of plaster of the present invention
2Containing the crude drug quality is 5.5g-9.0g.
The present invention is directed to " caused by liver and kidney deficiency, qi and blood deficiency " cervical spondylotic radiculopathy.
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali in the side.Sweet in the mouth, slightly warm in nature.Return spleen, lung meridian.Go into edema caused by disorder of QI.But the merit tonifying Qi and lifting yang, the Tuoli expelling pathogenic factors from the exterior." all families of solar corona book on Chinese herbal medicine " Yan Qike " help gas, strengthening bone and muscle is put on flesh, enrich blood ... metrorrhagia, leukorrhagia "." medicine origin " is carried it: " tonifying the lung gas, real fur, eliminating the pathogens from the lung moderate heat, stringy pulse spontaneous perspiration.Be apt to control weakness of the spleen and stomach, the skin infection blood vessels are not all right, expelling the toxic substance from the body with tonic YIN syndrome skin infection." Shennong's Herbal: " main carbuncle loses skin ulcer for a long time, the evacuation of pus pain relieving; Strong wind leprosy disease, five hemorrhoid scrofula, tonify deficiency, children's's all kinds of diseases and ailments." " Mingyi Bielu ": " control the dirty ailment said due to cold or exposure gas of married woman's, by stagnant blood between the five internal organs, it is deficient to mend the husband, and the five kinds of over strain weakness and emaciation quenches the thirst, stomachache dysentery, QI invigorating, Li Yin gas." " property of medicine opinion ": " and control carbuncle on the back, the main dyspnea due to deficiency of interior benefit, renal failure, deafness is treated cold and heat.”
Herba Epimedii is the dried leaves of Berberidaceae plant Herba Epimedii, arrow leaf Herba Epimedii, pubescence Herba Epimedii or Herba Epimedii.Hot, sweet, warm.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling.Be used for kidney yang deficiency, muscles and bones is withered soft, rheumatic arthralgia, numbness contracture." Mingyi Bielu ": " hard kidney bone.Disappear scrofula, red carbuncle, skin ulcer is arranged at the bottom." " big bright book on Chinese herbal medicine ": " control all cold wind consumptive disease.Mend the waist knee joint, heart tonifying power.”
Colla cornus cervi is that Cornu Cervi boils, concentrates the solid gum of processing through decocting.Sweet, salty, temperature.Return kidney, Liver Channel.The temperature compensation Liver and kidney, beneficial intensive culture blood.Be used for the asthenia weakness and emaciation due to the deficiency of the liver and kindey, carbuncle of yin nature swells and ache.
Ramulus Cinnamomi is the cinnamomic dry twig of canella.Have the effect of warming the meridian and promoting blood circulation, can be used for arthralgia.Hot, sweet, temperature.GUIXIN, lung, urinary bladder channel.Shennong's Herbal: " Your Majesty's gas cough with dyspnea, stagnation of QI, sore throat are told suction, sharp joint." " Mingyi Bielu ": " pained, the side of body wind side of body is painful, and warming the meridian and promoting blood circulation ends tired the perspiration." " herbal classic dredge card ": " and with seek, activate yang, diuretic, the therapeutic method to keep the adverse QI flowing downwards, clots absorbing, invigorating middle warmer, be Ramulus Cinnamomi six large effects.”
When the dry root that is classified as umbelliferae angelica.Sweet, hot, temperature.Return liver, the heart, spleen channel.Have and invigorate blood circulation, the analgesic effect is used for traumatic injury, carbuncle stasis pain, rheumatic arthralgia etc. more.Shennong's Herbal: " main cough with dyspnea, warm cruel cold and heat ...; Married woman's sterilization that leaks down; All malignant boil infectionss, incised wound." " Mingyi Bielu ": " and warming middle-JIAO to relieve pain removes plug in the objective blood, the apoplexy no sweating, and arthralgia chiefly caused by damp pathogen ... Tonifying five ZANG-organs, granulation promoting meat." " big bright book on Chinese herbal medicine ": " broken stagnant blood is supported fresh blood, You Zhu wei addiction." Compendium of Material Medica: " control headache, all pain of trusted subordinate.Intestine moistening stomach, muscles and bones, skin.Control carbuncle, the evacuation of pus pain relieving.Enrich blood with blood.”
Radix Paeoniae Rubra is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Bitter, be slightly cold.Return Liver Channel.Has clearing away heat and cooling blood, the effect of eliminating stasis to stop pain.Be used for injury from falling down, the carbuncle skin infection." Bencao Pinhui Jingyao ": " diuresis, the therapeutic method to keep the adverse QI flowing downwards are passed through, clear and coherent blood vessels, dispelling malignant blood, subduing inflammation.Cure mainly blood, pain relieving." essentials of Matea Medica: " and Radix Paeoniae Rubra cures mainly slightly with (Radix Paeoniae Alba), especially can removing fire from the liver, dispelling malignant blood is controlled hard long-pending, the arthralgia due to stagnation of blood hernia abdominal mass of stomachache, amenorrhea hemorrhoidal hamorrhage, carbuncle conjunctival congestion, can promoting the circulation of blood in stagnating.”
Sanguis Draxonis is the resin that the resiniferous wood of liliaceous plant arrow leaf Folium Dracaenae cambodianae obtains through extraction.Has promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, the effect of expelling pus and promoting granulation.Be used for traumatic injury, blood stasis is had a pain, traumatic hemorrhage, and skin infection does not close up for a long time.
Radix Notoginseng is the dry root and the rhizome of panax araliaceae plant.Sweet, little hardship, temperature.Return liver, stomach warp.Has the dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain.Compendium of Material Medica: " hemostasis, the blood that looses, analgesic therapy.Gold sword arrow is hindered, and falls and pounces on flogging injury, and blood goes out more than person, chew mashed being coated with, or for mixing it in the end, its blood ends promptly.Also main haematemesis, epistaxis, hematochezia, dysentery, metrorrhagia, incessant menorrhea.”
Flos Carthami is the dried floral of feverfew Flos Carthami.Have and invigorate blood circulation, the effect of eliminating stasis to stop pain.Be used for traumatic injury, blood stasis is had a pain, and also can be used for the carbuncle skin infection." Kaibao Bencao ": " its Seedling life is smashed to pieces, applies trip and swells." " Amplification on Materia Medica addendum ": " and how to bleed with broken, few with nourishing blood." Compendium of Material Medica: " invigorate blood circulation and moisturize, pain-relieving powder for treating is swollen, stimulates the menstrual flow.”
Olibanum is hot, bitter, warm.GUIXIN, liver, spleen channel.The analgesic therapy of invigorating blood circulation, detumescence and promoting granulation is used for rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, carbuncle skin infection." Mingyi Bielu ": " it is swollen to treat the edema due to wind pathogen poison, removes bad odor, treats the urticaria poison of itching." supplement to the Herbal: " and treat deaf, the apoplexy locked mouth, married woman's vim and vigour, can hair wine reason air-cooled, end large intestine and let out trip, treatment makes internal diabetes at skin ulcer." Compendium of Material Medica: " and all poison of eliminating carbuncle cellulitis, the heart is protected in the Tuoli, and muscle is stretched in the analgesic therapy of invigorating blood circulation, and controls married woman's dystocia folding and hinders.”
Herba Lycopodii is the dry herb of lycopsid Lycopodium clavatum.Little hardship, suffering, temperature.Return the liver,spleen,kidney warp.Has expelling wind and removing dampness, the effect of relaxing muscles and tendons and activating QI and blood in the collateral.Be used for joint aches, joint stuffiness.Supplement to the Herbal: " owner suffers from painful cold, the munbness of migratory arthralgia, foot knee joint for a long time, strength is weak.”
Semen Sinapis is the dry mature seed of crucifer Caulis et Folium Sinapis albee or mustard.Hot, warm, return lung meridian.Tool resolving mass and removing the obstruction of the collateral analgesic effect is used for the stagnant meridians of expectorant, joint numbness, pain, carbuncle of yin nature toxic swelling." Mingyi Bielu ": " master penetrates worker and chronic infectious disease gas, goes up gas, diaphoresis, cold, the yellowish complexion of chest and diaphragm expectorant." Compendium of Material Medica: " and the promoting the circulation of QI eliminating phlegm, remove cold warm in, the swollen pain relieving of loosing, control breathe heavily cough, regurgitation, numbness wood beriberi, all pains of muscles and bones waist joint.”
Borneolum Syntheticum is a borneolum syntheticum.Hot, bitter, be slightly cold.GUIXIN, spleen, lung meridian.Has the refreshment of having one's ideas straightened out, the effect of clearing away heat to alleviate pain." Newly Revised Canon of Materia Medica ": " main trusted subordinate's pathogen, rheumatism is gathered, and deafness makes eye bright, and goes conjunctival congestion skin nebula." supplement to the Herbal: " logical nine orifices is controlled trusted subordinate's gas ... It is silently painful to end heat, wind-phlegm, all worms in stop alvus and the skin, main again diseases due to noxious agents produced by various parasites.”
Chinese medicine ability of the present invention invigorating the liver and kidney, benefiting QI for activating blood circulation pain relieving, convenient in application, determined curative effect, clinical therapeutic efficacy is good.
Use Chinese medicine plaster of the present invention and carried out the animal test of pesticide effectiveness, determined curative effect.
Combine the therapeutical effect of cervical spondylosis animal model that its beneficial effect is described through medicine of the present invention to sound power below.
1. sound power combines the preparation of cervical spondylosis animal model
Wistar strain rat; Be divided into sound power and combine cervical spondylosis animal model group and sham operated rats; Sound power combines cervical spondylosis model group rat anesthesia tailing edge nape portion median incision, vertically cuts skin and subcutaneous tissue 2～2.5cm, cuts deep fascia and exposes the musculi colli layer; Cut off shallow crowd's flesh earlier, comprise platysma, neck trapezius muscle, head and neck rhomboideus; Cut off dark muscle group again, comprise cervical region splenius, musculus longissimus (longissimus capitis, atlanto longissimus, longissimus cervicis), iliocostalis cervicis and semispinalis capitis; Excise supraspinal ligament and the interspinal ligaments of C2～C7 at last, skin suture carries out behavioristics's test to rat after the modeling, confirms that sound power combines cervical spondylosis animal model rat modeling success.Sham operated rats is only cut skin and subcutaneous tissue, does not cut off musculi colli, does not also excise supraspinal ligament and the interspinal ligaments of C2～C7, directly skin suture.
2. medication
Rat after the modeling is divided into model group, drug group of the present invention and control drug group.Rat back is shaved hair, and area is about (4 * 4) cm
2, respectively organize rat every day and stick difference and tried thing, by following method administration: 1. sham operated rats, the sham operated rats rat gives blank plaster, totally 15 days.2. model group, rat model gives blank plaster, totally 15 days.3. drug group of the present invention, sound power combine the cervical spondylosis rat model to give the embodiment of the invention 1, embodiment 4, embodiment 6, embodiment 9 medicines respectively, award 6.3cm according to per kilogram of body weight
2Standard stick ointment, be administered once every day, continuous 15 days.4. control drug group (unblocking collaterals to treat arthritis subsides group), sound power combine the cervical spondylosis rat model to give unblocking collaterals to treat arthritis to paste, award 6.3cm according to per kilogram of body weight
2Standard stick ointment, be administered once every day, continuous 15 days.The behavioristics of detecting rat behind the medicine changes and pressure pain in foot threshold value change situation.
3. result of the test
1. behavioristics's variation model treated animal time daily shows as right upper extremity in operation back and is close to the front, dare not contact to earth, and toe tightens, and elbow, carpal joint are stiff.Behind the administration 7d, drug group rat elbow joint of the present invention can contact to earth and creep, and model group and unblocking collaterals to treat arthritis subsides group rat still show as upper limb and be close to the front, dare not contact to earth.Behind the treatment 10d, some rat of drug group of the present invention can be contacted to earth with carpal joint and creeped, and the unblocking collaterals to treat arthritis subsides are organized available elbow joint and contacted to earth and creep, and model group has individual animal to contact to earth with elbow joint to creep.Behind the treatment 15d; The all available carpal joint of drug group rat of the present invention contacts to earth and creeps; Unblocking collaterals to treat arthritis subsides group part animal can be contacted to earth with carpal joint, and some rat elbow joint of model group can contact to earth and creep, and shows that medicine of the present invention can improve the variation of animal pattern behavioristics aspect.
When 2. pain threshold changes administration 15d with pressing the right front palm central part of tail appearance compressing rat, with rat struggle, pressure when shouting is as the pain threshold of this rat.Experimental result is seen table 1.
The easypro paster of table 1. cervicodynia combines the therapeutical effect (
n=10) of cervical spondylosis animal model to sound power
Annotate: compare #P＜0.05, ##P＜0.01, ###P＜0.001 with model control group
Table 1 is visible, and pain threshold is model group-control drug group-drug group-sham operated rats of the present invention and increases progressively trend successively.Statistical procedures shows, compares with model control group, and drug group pain threshold of the present invention has extremely significant difference (P＜0.001), and the raising rate is superior to unblocking collaterals to treat arthritis subsides group.
Experimental result demonstrates medicine of the present invention and combines unusual form and the behavioral indicator of cervical spondylosis animal model rat to have a better role to sound power, can improve pain threshold, effectively improves the symptom of cervical spondylosis.
Use Chinese medicine plaster of the present invention 30 routine cervical spondylotic radiculopathyes have been carried out the clinical observation summary, obtained clinical efficacy preferably.Clinical physical data: 30 examples are outpatient service and inpatient, minimum 25 years old of age, maximum 60 years old, 46 years old mean age.
One. diagnostic criteria:
Chinese medical discrimination: primary symptom: root pain, numbness and identical with Radiologic imaging; The person's back distending pain is heavy, and waist knee joint epidemic disease is soft, and legs and feet knot, aversion to cold and cold limbs.Secondary symptoms: more obvious osteoarthritis and / or osteoporosis radiographic evidence; may be associated with headache, vertigo, tinnitus, palpitations, nocturia, Huang white or sallow complexion, poor appetite eat less, shortness of breath, sound and mood , pale tongue, white, weak pulse.Include the case standard in:
Meet tcm diagnosis standard and dialectical person, can include the test case in.
Get rid of the case standard:
The outer pathological changes (like thoracic outlet syndrome, scapulohumeral periarthritis) of cervical vertebra, cervical spinal canal is narrow, cervical vertebra and intraspinal tumor, with the hematopathy of bleeding tendency, tuberculosis of bone and joint, osteomyelitis and senile osteoporosis and the unusual person of serious heart and brain hepatic and renal function.
Two. observation index:
Safety observation:
Curative effect observation: relevant symptoms and sign; Picture of the tongue, pulse condition change.
Curative effect determinate standard:
Recovery from illness: symptom and sign integration reduce >=95%, and the X line shows normal;
Produce effects symptom and sign integration reduce >=70%,＜95%, and the demonstration of X line is clearly better;
Effectively: symptom and sign integration reduce >=30%,＜75%, and the X line shows improvement;
Invalid: root property syndrome and sign integration reduce less than 30%, and the X line shows does not have change;
Annotate: computing formula is: [integration before (integration before the treatment-treatment back integration) ÷ treatment] * 100%.
Three. Therapeutic Method: external.With embodiment 1 plaster, paste for 1 time 1,1 time on the one, 15 days is a course of treatment.
Four. therapeutic effect:
Among the 30 routine patients, 17 examples of fully recovering account for 56.7%; Produce effects 11 examples account for 36.7%; Invalid 2 examples account for 6.6%, total effective rate 934%.
Safety indexes detects: in clinical observation, 30 routine patients have been carried out medication front and back routine blood test, routine urinalysis and liver, kidney function test, the result shows the equal no abnormality seen of each item index before and after the 30 routine patient treatments.
Untoward reaction: do not have obviously poison pair effect and untoward reaction.
The specific embodiment
Embodiment 1
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: 30 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts of Herba Epimedii, 15 parts of Colla cornus cervis, 10 parts of Radix Paeoniae Rubra, 10 parts of Ramulus Cinnamomi, 10 parts of Sanguis Draxonis, 10 parts of Herba Lycopodiis, 10 parts in Semen Sinapis, 10 parts of Radix Notoginseng, 10 parts on Flos Carthami, 10 parts of Olibanums, 10 parts of Borneolum Syntheticums.
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 4 times of its quality, molten, being concentrated into relative density is the Colla cornus cervi cream of 1.25 (65 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 3 times; Each ethanol that adds 80% (V/V) of 6 times of Radix Notoginseng quality refluxed 1.5 hours at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.20 (60 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 4 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 6 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 3 times adds the water of 8 times of medicine gross masses at every turn; The each decoction 2 hours; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.10 (50 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 60% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.20 (70 ℃);
(7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Again with itself and propylene glycol (consumption is the 5%m/m of medicament mixed cream amount), azone (consumption is the 2%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive (consumption be medicament mixed cream amount 60) %m/m) pressure sensitive adhesive, acrylic resin (consumption is the 5%m/m of medicament mixed cream amount), polyvinylpyrrolidone (consumption is the 5%m/m of medicament mixed cream amount) mixing; Coating; Drying adds protective layer; Every subsides specification 7cm * 10cm.The present embodiment plaster, every 100cm
2Contain crude drug quality 7.2g.
Embodiment 2
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: 25 parts of the Radixs Astragali, 12 parts of Radix Angelicae Sinensis, 15 parts of Herba Epimedii, 10 parts of Colla cornus cervis, 8 parts of Radix Paeoniae Rubra, 8 parts of Ramulus Cinnamomi, 8 parts of Sanguis Draxonis, 8 parts of Herba Lycopodiis, 8 parts in Semen Sinapis, 8 parts of Radix Notoginseng, 8 parts on Flos Carthami, 8 parts of Olibanums, 6 parts of Borneolum Syntheticums.
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 2 times of its quality, foreignize, being concentrated into relative density is the Colla cornus cervi cream of 1.35 (50 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 2 times; Each ethanol that adds 60% (V/V) of 5 times of Radix Notoginseng quality refluxed 0.5 hour at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.05 (80 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 3 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 4 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 2 times adds the water of 4 times of medicine gross masses at every turn; The each decoction 0.5 hour; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.05 (80 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 50% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.35 (80 ℃);
(7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Again with itself and propylene glycol (consumption is the 2%m/m of medicament mixed cream amount), azone (consumption is the 1%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive (consumption is the 55%m/m of medicament mixed cream amount), acrylic resin (consumption is the 3%m/m of medicament mixed cream amount), polyvinylpyrrolidone (consumption is the 3%m/m of medicament mixed cream amount) mixing; Coating; Drying adds protective layer; Every subsides specification 7cm * 10cm.The present embodiment plaster, every 100cm
2Contain crude drug quality 7.9g.
Embodiment 3
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: 33 parts of the Radixs Astragali, 18 parts of Radix Angelicae Sinensis, 25 parts of Herba Epimedii, 18 parts of Colla cornus cervis, 12 parts of Radix Paeoniae Rubra, 12 parts of Ramulus Cinnamomi, 12 parts of Sanguis Draxonis, 12 parts of Herba Lycopodiis, 12 parts in Semen Sinapis, 12 parts of Radix Notoginseng, 12 parts on Flos Carthami, 12 parts of Olibanums, 12 parts of Borneolum Syntheticums.
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 6 times of its quality, foreignize, being concentrated into relative density is the Colla cornus cervi cream of 1.10 (80 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 4 times; Each ethanol that adds 85% (V/V) of 15 times of Radix Notoginseng quality refluxed 3 hours at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.35 (50 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 8 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 10 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 4 times adds the water of 15 times of medicine gross masses at every turn; The each decoction 3 hours; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.20 (50 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 75% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.35 (50 ℃);
(7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Again with itself and propylene glycol (consumption is the 10%m/m of medicament mixed cream amount), azone (consumption is the 5%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive (consumption is the 75%m/m of medicament mixed cream amount), acrylic resin (consumption is the 10%m/m of medicament mixed cream amount), polyvinylpyrrolidone (consumption is the 10%m/m of medicament mixed cream amount) mixing; Coating; Drying adds protective layer; Specification 7cm * 10cm.The present embodiment plaster, every 100cm
2Contain crude drug quality 7.5g.
Embodiment 4
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: 20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 15 parts of Herba Epimedii, 5 parts of Colla cornus cervis, 6 parts of Radix Paeoniae Rubra, 6 parts of Ramulus Cinnamomi, 3 parts of Sanguis Draxonis, 6 parts of Herba Lycopodiis, 6 parts in Semen Sinapis, 6 parts of Radix Notoginseng, 6 parts on Flos Carthami, 6 parts of Olibanums, 3 parts of Borneolum Syntheticums.
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 2 times of its quality, foreignize, being concentrated into relative density is the Colla cornus cervi cream of 1.10 (80 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 2 times; Each ethanol that adds 60% (V/V) of 5 times of Radix Notoginseng quality refluxed 0.5 hour at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.05 (50 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 3 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 4 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 2 times adds the water of 4 times of medicine gross masses at every turn; The each decoction 0.5 hour; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.05 (50 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 50% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.15 (50 ℃);
(7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Be the 55%m/m of medicament mixed cream amount with itself and propylene glycol (consumption is the 2%m/m of medicament mixed cream amount), azone (consumption is the 1%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive consumption again), acrylic resin (consumption is the 3%m/m of medicament mixed cream amount), polyvinylpyrrolidone (consumption is the 3%m/m of medicament mixed cream amount) mixing; Coating; Drying adds protective layer; Specification is 7cm * 10cm.The present embodiment plaster, every 100cm
2Contain crude drug quality 8.1g.
Embodiment 5
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: 40 parts of the Radixs Astragali, 25 parts of Radix Angelicae Sinensis, 30 parts of Herba Epimedii, 25 parts of Colla cornus cervis, 20 parts of Radix Paeoniae Rubra, 20 parts of Ramulus Cinnamomi, 20 parts of Sanguis Draxonis, 20 parts of Herba Lycopodiis, 20 parts in Semen Sinapis, 20 parts of Radix Notoginseng, 20 parts on Flos Carthami, 20 parts of Olibanums, 13 parts of Borneolum Syntheticums.
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 6 times of its quality, foreignize, being concentrated into relative density is the Colla cornus cervi cream of 1.35 (80 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 4 times; Each ethanol that adds 85% (V/V) of 15 times of Radix Notoginseng quality refluxed 3 hours at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.35 (80 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 8 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 10 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 4 times adds the water of 15 times of medicine gross masses at every turn; The each decoction 3 hours; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.20 (80 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 75% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.35 (80 ℃);
(7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Again with itself and propylene glycol (consumption is the 10%m/m of medicament mixed cream amount), azone (consumption is the 5%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive (consumption is the 75%m/m of compound amount), acrylic resin (consumption is the 10%m/m of compound amount), polyvinylpyrrolidone (consumption is the 10%m/m of compound amount) mixing; Coating; Drying adds protective layer; Specification is 7cm * 10cm.The present embodiment plaster, every 100cm
2Contain crude drug quality 7.5g.
Embodiment 6
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug is formed with embodiment 1
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 2 times of its quality, foreignize, being concentrated into relative density is the Colla cornus cervi cream of 1.02 (50 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 2 times; Each ethanol that adds 60% (V/V) of 5 times of Radix Notoginseng quality refluxed 0.5 hour at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.05 (50 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 3 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 4 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 2 times adds the water of 4 times of medicine gross masses at every turn; The each decoction 0.5 hour; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.10 (50 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 50% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.15 (50 ℃);
(7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Again with itself and propylene glycol (consumption is the 2%m/m of medicament mixed cream amount), azone (consumption is the 1%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive (consumption is the 55%m/m of medicament mixed cream amount), acrylic resin (consumption is the 3%m/m of medicament mixed cream amount), polyvinylpyrrolidone (consumption is the 3%m/m of medicament mixed cream amount) mixing; Coating; Drying adds protective layer; Specification is every subsides 7cm * 10cm, present embodiment plaster, every 100cm
2Contain crude drug quality 7.6g.
Embodiment 7
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: with embodiment 1.
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 6 times of its quality, foreignize, being concentrated into relative density is the Colla cornus cervi cream of 1.35 (80 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 4 times; Each ethanol that adds 85% (V/V) of 15 times of Radix Notoginseng quality refluxed 3 hours at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.35 (80 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 8 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 10 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 4 times adds the water of 15 times of medicine gross masses at every turn; The each decoction 3 hours; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.20 (80 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 75% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.35 (80 ℃); (7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Be the 10%m/m of medicament mixed cream amount with itself and propylene glycol (consumption is the 10%m/m of medicament mixed cream amount), azone (consumption is the 4%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive (consumption is the 75%m/m of medicament mixed cream amount), acrylic resin (consumption is the 10%m/m of medicament mixed cream amount), polyvinylpyrrolidone consumption again) mixing; Coating; Drying adds protective layer; Specification is every subsides 7cm * 10cm.The present embodiment plaster, every 100cm
2Contain crude drug quality 9.0g.
Embodiment 8
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: 25 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts of Herba Epimedii, 9 parts of Colla cornus cervis, 9 parts of Radix Paeoniae Rubra, 9 parts of Ramulus Cinnamomi, 5 parts of Sanguis Draxonis, 9 parts of Herba Lycopodiis, 9 parts in Semen Sinapis, 9 parts of Radix Notoginseng, 9 parts on Flos Carthami, 9 parts of Olibanums, 5 parts of Borneolum Syntheticums.
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 5 times of its quality, foreignize, being concentrated into relative density is the Colla cornus cervi cream of 1.25 (65 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 2 times; Each ethanol that adds 75% (V/V) of 6 times of Radix Notoginseng quality refluxed 2 hours at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.10 (70 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 3.5 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 6 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 2 times adds the water of 10 times of medicine gross masses at every turn; The each decoction 2 hours; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.10 (60 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 60% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.20 (65 ℃);
(7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Again with itself and propylene glycol (consumption is the 6%m/m of medicament mixed cream amount), azone (consumption is the 3%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive (consumption is the 60%m/m of medicament mixed cream amount), acrylic resin (consumption is the 6%m/m of medicament mixed cream amount), polyvinylpyrrolidone (consumption is the 4%m/m of medicament mixed cream amount) mixing; Coating; Drying adds protective layer; Specification is every obedient 7cm * 10cm.The present embodiment plaster, every 100cm
2Contain crude drug quality 5.5g.
Embodiment 9
A kind of Chinese medicine plaster of treating cervical spondylotic radiculopathy, the weight part ratio of its crude drug consists of: 25 parts of the Radixs Astragali, 18 parts of Radix Angelicae Sinensis, 25 parts of Herba Epimedii, 10 parts of Colla cornus cervis, 12 parts of Radix Paeoniae Rubra, 12 parts of Ramulus Cinnamomi, 8 parts of Sanguis Draxonis, 12 parts of Herba Lycopodiis, 12 parts in Semen Sinapis, 8 parts of Radix Notoginseng, 12 parts on Flos Carthami, 12 parts of Olibanums, 6 parts of Borneolum Syntheticums.
Preparation technology:
(1) Sanguis Draxonis, Borneolum Syntheticum powder are broken into Sanguis Draxonis, Borneolum Syntheticum fine powder, cross No. five sieves (80 order);
(2) Colla cornus cervi is ground into fine powder, crosses a sieve (10 order), add the water of 3 times of its quality, foreignize, being concentrated into relative density is the Colla cornus cervi cream of 1.02 (80 ℃);
(3) Radix Notoginseng is pulverized, cross a sieve (10 order), alcohol reflux 3 times; Each ethanol that adds 75% (V/V) of 10 times of Radix Notoginseng quality refluxed 1.5 hours at every turn, filtered; Merging filtrate, decompression recycling ethanol also is condensed into Radix Notoginseng alcohol extraction condensed cream, and relative density is 1.05 (80 ℃);
(4) Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are added the water of 3 times of its quality; Vapor distillation extracts volatile oil, and the time of extracting volatile oil is 8 hours, and volatile oil is subsequent use; Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi are merged, decocte with water 3 times adds the water of 10 times of medicine gross masses at every turn; The each decoction 1.5 hours; Filter, merge, be decocting liquid; Decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil, and being concentrated into relative density is the water drug-decocting concentrating liquid of 1.08 (70 ℃);
(6) water drug-decocting concentrating liquid is added 95% (V/V) ethanol and stir, make it contain amount of alcohol and reach 60% (m/m) and staticly settle and filter, with decompression filtrate recycling ethanol and be concentrated into the water decoction-alcohol sedimentation concentrated extract that relative density is 1.30 (60 ℃); (7) volatile oil of Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream and water decoction-alcohol sedimentation concentrated extract and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is merged be mixed into medicament mixed cream; Again with itself and propylene glycol (consumption is the 3%m/m of medicament mixed cream amount), azone (consumption is the 4%m/m of medicament mixed cream amount), acrylate pressure-sensitive adhesive (consumption is the 60%m/m of medicament mixed cream amount), acrylic resin (consumption is the 7%m/m of medicament mixed cream amount), polyvinylpyrrolidone (consumption is the 8%m/m of medicament mixed cream amount) mixing; Coating; Drying adds protective layer; The every subsides of specification are 7cm * 10cm.The present embodiment plaster, every 100cm
2Contain crude drug quality 6.3g.
Claims (8)
1. Chinese medicine plaster of treating cervical spondylotic radiculopathy; It is characterized in that the weight part ratio of its crude drug consists of: Radix Astragali 20-40 part, Radix Angelicae Sinensis 10-25 part, Herba Epimedii 15-30 part, Colla cornus cervi 5-25 part, Radix Paeoniae Rubra 6-20 part, Ramulus Cinnamomi 6-20 part, Sanguis Draxonis 3-20 part, Herba Lycopodii 6-20 part, Semen Sinapis 6-20 part, Radix Notoginseng 6-20 part, Flos Carthami 6-20 part, Olibanum 6-20 part, Borneolum Syntheticum 3-13 part.
2. the Chinese medicine plaster of treatment cervical spondylotic radiculopathy according to claim 1; It is characterized in that the weight part ratio of its crude drug consists of: Radix Astragali 25-33 part, Radix Angelicae Sinensis 12-18 part, Herba Epimedii 15-25 part, Colla cornus cervi 10-18 part, Radix Paeoniae Rubra 8-12 part, Ramulus Cinnamomi 8-12 part, Sanguis Draxonis 8-12 part, Herba Lycopodii 8-12 part, Semen Sinapis 8-12 part, Radix Notoginseng 8-12 part, Flos Carthami 8-12 part, Olibanum 8-12 part, Borneolum Syntheticum 6-12 part.
3. the Chinese medicine plaster of treatment cervical spondylotic radiculopathy according to claim 2; It is characterized in that the weight part ratio of its crude drug consists of: 30 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts of Herba Epimedii, 15 parts of Colla cornus cervis, 10 parts of Radix Paeoniae Rubra, 10 parts of Ramulus Cinnamomi, 10 parts of Sanguis Draxonis, 10 parts of Herba Lycopodiis, 10 parts in Semen Sinapis, 10 parts of Radix Notoginseng, 10 parts on Flos Carthami, 10 parts of Olibanums, 10 parts of Borneolum Syntheticums.
4. the method for preparing of the Chinese medicine plaster of each described treatment cervical spondylotic radiculopathy of claim 1-3 is characterized in that, comprises the steps:
(1) Sanguis Draxonis, Borneolum Syntheticum pulverize separately are become fine powder, subsequent use;
(2) Colla cornus cervi crushing and water-adding molten is become Colla cornus cervi cream, subsequent use;
(3) Radix Notoginseng is pulverized and adds ethanol extraction, filters, and reclaims ethanol, and is condensed into Radix Notoginseng alcohol extraction condensed cream, and is subsequent use;
(4) with Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation volatile oil, volatile oil is subsequent use, and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues behind the extraction volatile oil are deposited in addition, and combining medicine is in decocting liquid;
(5) Olibanum behind the Radix Astragali, Radix Paeoniae Rubra, Herba Epimedii, Herba Lycopodii, Flos Carthami and the extraction volatile oil, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi medicinal residues are merged; Decocte with water; Filter, merge into decocting liquid, decocting liquid and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi extract the combining medicine behind the volatile oil; And be condensed into water drug-decocting concentrating liquid, subsequent use;
(6) (5) water drug-decocting concentrating liquid is added ethanol and stir, leave standstill, deposition filters, and filtrate recycling ethanol also is condensed into the water decoction-alcohol sedimentation concentrated extract, and is subsequent use;
(7) volatile oil with Sanguis Draxonis, Borneolum Syntheticum fine powder, Colla cornus cervi cream, Radix Notoginseng alcohol extraction condensed cream, water decoction-alcohol sedimentation condensed cream and Olibanum, Semen Sinapis, Radix Angelicae Sinensis, Ramulus Cinnamomi water vapour distillation is mixed into medicament mixed cream; Again with itself and Percutaneous absorption enhancer, pressure sensitive adhesive, macromolecular material mixing; Coating; Drying adds protective layer.
5. the method for preparing of the Chinese medicine plaster of treatment cervical spondylotic radiculopathy according to claim 4 is characterized in that, 1.10-1.35 when Colla cornus cervi cream relative density is 50-80 ℃; 1.10-1.35 when Radix Notoginseng alcohol extraction condensed cream relative density is 50-80 ℃; 1.05-1.20 when the water drug-decocting concentrating liquid relative density is 50-80 ℃; 1.10-1.35 when water decoction-alcohol sedimentation concentrated extract relative density is 50-80 ℃.
6. the method for preparing of the Chinese medicine plaster of treatment cervical spondylotic radiculopathy according to claim 4; It is characterized in that; Described Percutaneous absorption enhancer is propylene glycol and azone, and pressure sensitive adhesive is an acrylate pressure-sensitive adhesive, and macromolecular material is acrylic resin and polyvinylpyrrolidone.
7. the method for preparing of the Chinese medicine plaster of treatment cervical spondylotic radiculopathy according to claim 6; It is characterized in that; Described propylene glycol consumption is the 2-10% of medicament mixed cream quality, and the azone consumption is the 1-5% of medicament mixed cream quality, and the acrylate pressure-sensitive adhesive consumption is the 55-75% of medicament mixed cream quality; The acrylic resin consumption is the 3-10% of medicament mixed cream quality, and the polyvinylpyrrolidone consumption is the 3-10% of medicament mixed cream quality.
8. the method for preparing of the Chinese medicine plaster of treatment cervical spondylotic radiculopathy according to claim 4 is characterized in that, every 100cm
2It is 5.5g-9.0g that plaster contains the crude drug quality.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104306536A (en) * | 2014-09-27 | 2015-01-28 | 王纬 | A plaster for treating nerve-root type cervical spondylosis and a preparing method thereof |
| CN104474517A (en) * | 2014-12-17 | 2015-04-01 | 冯文光 | Chinese patent medicine for treating cervical syndrome and preparation method |
| CN104706793A (en) * | 2015-02-25 | 2015-06-17 | 黄桂荣 | Traditional Chinese medicine anaesthesia pain relieving tincture for treating nerve-root type cervical spondylosis |
| CN106266361A (en) * | 2015-06-03 | 2017-01-04 | 怀化学院 | A kind of External-applicationChinese Chinese medicinal preparation treating cervical and lumbar diseases |
| CN106798886A (en) * | 2017-02-09 | 2017-06-06 | 广西大学 | A kind of Chinese medicinal plaster for waist cervical spondylopathy |
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| CN1418696A (en) * | 2002-12-13 | 2003-05-21 | 马新华 | Traditional Chinese medicine prepn. for treating cervical vertebra disease |
| CN1615972A (en) * | 2004-09-29 | 2005-05-18 | 周丽梅 | Medicine for treating arthraligia caused by wind, cold and wetness evils and with beauty function and its preparing method |
| CN1736452A (en) * | 2005-07-26 | 2006-02-22 | 殷复广 | Medicine for matching with micro-traumatic surgery and its preparing process |
| WO2008112561A1 (en) * | 2007-03-09 | 2008-09-18 | Pfantastic Medical Research Institute, Llc | Combination therapy for alleviating pain-related conditions |
| CN101773642A (en) * | 2010-02-26 | 2010-07-14 | 陈德林 | Gukangling plaster formula for activating blood and dissolving stasis and preparation method |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1418696A (en) * | 2002-12-13 | 2003-05-21 | 马新华 | Traditional Chinese medicine prepn. for treating cervical vertebra disease |
| CN1615972A (en) * | 2004-09-29 | 2005-05-18 | 周丽梅 | Medicine for treating arthraligia caused by wind, cold and wetness evils and with beauty function and its preparing method |
| CN1736452A (en) * | 2005-07-26 | 2006-02-22 | 殷复广 | Medicine for matching with micro-traumatic surgery and its preparing process |
| WO2008112561A1 (en) * | 2007-03-09 | 2008-09-18 | Pfantastic Medical Research Institute, Llc | Combination therapy for alleviating pain-related conditions |
| CN101773642A (en) * | 2010-02-26 | 2010-07-14 | 陈德林 | Gukangling plaster formula for activating blood and dissolving stasis and preparation method |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306536A (en) * | 2014-09-27 | 2015-01-28 | 王纬 | A plaster for treating nerve-root type cervical spondylosis and a preparing method thereof |
| CN104474517A (en) * | 2014-12-17 | 2015-04-01 | 冯文光 | Chinese patent medicine for treating cervical syndrome and preparation method |
| CN104706793A (en) * | 2015-02-25 | 2015-06-17 | 黄桂荣 | Traditional Chinese medicine anaesthesia pain relieving tincture for treating nerve-root type cervical spondylosis |
| CN106266361A (en) * | 2015-06-03 | 2017-01-04 | 怀化学院 | A kind of External-applicationChinese Chinese medicinal preparation treating cervical and lumbar diseases |
| CN106798886A (en) * | 2017-02-09 | 2017-06-06 | 广西大学 | A kind of Chinese medicinal plaster for waist cervical spondylopathy |
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| CN102526406B (en) | 2013-09-18 |
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