CN101066303B - Medicine for treating cerebral thrombus, cerebral angiosclerosis, apoplexy and hemiplegia and its preparation - Google Patents
Medicine for treating cerebral thrombus, cerebral angiosclerosis, apoplexy and hemiplegia and its preparation Download PDFInfo
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Abstract
The present invention is one kind of medicine for treating cerebral thrombus, cerebral angiosclerosis, apoplexy and hemiplegia and its preparation process, and belongs to the field of Chinese medicine technology. The medicine is prepared with 13 kinds of Chinese medicinal materials, including earthworm, leech, red sage, cassia twig, ledebouriella root, etc in certain weight proportion, and may beprepared into different orally taken medicine forms. It has the functions of calming liver, promoting blood circulation to disperse blood clots, dredging meridian and others. It is used in treating said diseases, and has high curative effect.
Description
[technical field] the present invention relates to a kind of medicine of treating cerebral thrombosis, cerebrovascular sclerosis and apoplectic hemiplegia and preparation method thereof, belongs to the field of Chinese medicines.
[background technology] order cerebral thrombosis, cerebrovascular sclerosis and apoplectic hemiplegia are one of a kind of commonly encountered diseases, frequently-occurring disease in the middle-aged and elderly people, its symptom be facial hemiplegia, part dizziness headache, trigeminal neuralgia, aphasis, mouthful tiltedly, limb adynamia, walking disorder.Trace it to its cause, the traditional Chinese medical science is thought human body because of due to wind, fire, gas, the blood, and blood is capable contrary last with gas, makes the deficiency of YIN in down; YANG overacting in the uppper part, the transformation that interacts causes blood clotting or blood to be annotated; To cause some the bottom of heart pathogen puzzlement or some meridians by the stagnation of QI or the wet resistance of blood stasis, make blockage of main and collateral channels, ineffective.
This disease of traditional treatment adopts expectant treatment more, and the treatment phase is long, and curative effect is slow; Effect is not remarkable; There is the patient of this type disease to bring secular misery and inconvenience in life, vast cerebral thrombosis, cerebrovascular sclerosis and apoplectic hemiplegia patient, urgent hope has a kind of good effect; The treatment phase is short, the good medicine that does not recur after healing.
[summary of the invention] is long for overcoming existing treatment cerebral thrombosis, cerebrovascular sclerosis and apoplectic hemiplegia medicine treatment phase; Curative effect is slow; The very unfavorable defective of effect; It is short to the purpose of this invention is to provide a kind of treatment phase, and curative effect is fast, the medicine and the method for making thereof of obvious results treatment cerebral thrombosis, cerebrovascular sclerosis and apoplectic hemiplegia.
For solving its technical problem; The technical scheme that the present invention adopts is: to cerebral thrombosis, cerebrovascular sclerosis is because of qi depression to blood stasis; Theory due to the blockage of main and collateral channels, the raw material of Chinese medicine of choice of drug of the present invention has: Pheretima, Hirudo, Radix Salviae Miltiorrhizae, Ramulus Cinnamomi, windproof, Herba Asari, Lian Xin, Flos Carthami, Semen Persicae, Radix Polygalae, Radix Semiaquilegiae, Radix Clematidis, Rhizoma Chuanxiong.Wherein select LUMBRICUS for use: be salty-cold because of its nature and flavor, return liver, spleen, urinary bladder channel, function is heat clearing away arresting convulsion, the collateral dredging diuresis of relievining asthma; Hirudo: nature and flavor are salty, bitter, flat, slightly poisonous, return Liver Channel, and function is that removing blood stasis pursues silt, stimulates the menstrual flow; Radix Salviae Miltiorrhizae: property is bitter, is slightly cold, and GUIXIN, Liver Channel, function is a stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire; Ramulus Cinnamomi: hot, sweet, warm, GUIXIN, lung, urinary bladder channel, famine is separated in the function diaphoresis, warm beniol warp, supporing yang activating QI, the flat gas that spins; Windproof: hot, sweet, tepor, return bladder, liver, spleen channel, function are dispersing wind, relieving exterior syndromes, expelling wind and dampness, pain relieving.Herba Asari: hot, warm, slightly poisonous, return lung, kidney channel, function is to deliver cold expelling, warming the lung to eliminate phlegm, wind-expelling pain-stopping; Plumula Nelumbinis: bitter, cold, GUIXIN, kidney channel, function are clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding; Flos Carthami: suffering, temperature, GUIXIN, Liver Channel, function is a promoting blood circulation to restore menstrual flow, the dissipating blood stasis hemostasis; Semen Persicae: bitter, sweet, flat, GUIXIN, liver, intestinal warp, function is a blood circulation promoting and blood stasis dispelling, logical intestinal profit is just; Radix Polygalae: bitter, hot, warm, return kidney, lung meridian, function is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminating phlegm for diminishing swelling; Radix Semiaquilegiae: sweet, sweet, warm, return liver, stomach warp, function is a heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Radix Clematidis: hot, salty, warm, return urinary bladder channel, function is an expelling wind and dampness, inducing menstruation to relieve menalgia; Rhizoma Chuanxiong: hot, warm, return liver, gallbladder, heart channel, function is a blood-activating and qi-promoting, wind-expelling pain-stopping.
In order to reach better therapeutic, the present invention also selects for use the medicine of the blood pressure lowering of following ability, blood sugar lowering, wind-damp dispelling to make up, and makes each efficacy of drugs produce synergism.Selected crude drug and performance are following:
Rhizoma Gastrodiae: nature and flavor are sweet, flat, return Liver Channel, suppressing the hyperactive liver to relieve the wind syndrome, and relieving convulsion is removed the limbs fiber crops; Ramulus Uncariae Cum Uncis: sweet, cool, return liver, pericardium channel, the heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion is beneficial to and brings high blood pressure down; Scorpio: hot, flat poisonous, return Liver Channel, dispelling wind and relieving convulsion, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain is used for blood pressure lowering, apoplexy; Scolopendra: Xin Wen is poisonous, and endogenous wind stopping is relieving convulsion, dispersing pathogen accumulation, and removing obstruction in the collateral to relieve pain is used for apoplexy, facial hemiparalysis, hemiplegia; Zaocys: sweet, flat, return Liver Channel, dispel the wind, collateral dredging, relieving convulsion is used for wet low, numbness, apoplexy, hemiplegia; Eupolyphaga Seu Steleophaga: salty, cold, slightly poisonous, return Liver Channel, removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones is used for the muscles and bones folding and hinders the blood stasis amenorrhea; The Radix Astragali: sweet, warm, return the lung spleen channel, invigorating QI to consolidate the body surface resistance, sharp poison holding is arranged densely, and expelling pus and promoting granulation is used for blood pressure lowering, blood sugar lowering, heart tonifying, antiinflammatory, hepatoprotective, anti-gastric ulcer; Radix Notoginseng: sweet, little hardship, temperature, return liver, stomach warp, the dissipating blood stasis hemostasis, subduing swelling and relieving pain is used for traumatic injury, hemostasis; Olibanum: hot, temperature hardship, go into the heart, Liver Channel, muscle, detumescence, granulation promoting are stretched in the analgesic therapy of invigorating blood circulation, and are used for traumatic injury, carbuncle skin ulcer cellulitis; Myrrha: bitter, flat, go into Liver Channel, the dissipating blood stasis analgesic therapy, detumescence, pain relieving, granulation promoting is used for cholesterol reducing, the blood stasis of dispelling; Triangular: hot, bitter, return liver, spleen channel, function is the removing blood stasis circulation of qi promoting, reducing swelling and alleviating pain is used for blood stasis, amenorrhea, swollen splenomegaly; Rhizoma Curcumae: hot, bitter, warm, return liver, spleen channel, the circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving has crowded tumor, prolongs the effect of blood clotting time, is used for liver splenomegaly piece, the blood stasis amenorrhea; The Cortex Eucommiae: sweet, warm, return liver, spleen channel, the tonifying liver spleen, bone and muscle strengthening has the effect of blood pressure lowering, diuresis and contraction tremulous pulse; Radix Achyranthis Bidentatae: bitter, acid, flat, return liver, kidney channel, invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards is used for removing blood stasis and stimulates the menstrual flow, tire under the removing food stagnancy, antihypertensive diuretic; Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription is used to alleviate all poison of drug property, strong, increases curative effect; Caulis Spatholobi: bitter, sweet, warm, return liver, kidney channel, to enrich blood and invigorate blood circulation, the meridian dredging is used for paralysis and numbness, rheumatism low pain.
The consumption of medicine components of the present invention has carried out groping in a large number to sum up out through the inventor, and the each component consumption all has effect preferably in the following weight parts scope:
1.5～3 parts of LUMBRICUSs, 0.5～1 part of Hirudo, 3～5 parts of Radix Salviae Miltiorrhizaes, 1～3 part of Ramulus Cinnamomi, windproof 1.5～5 parts; 0.3～1.3 part of Herba Asari, 0.5～1 part of Plumula Nelumbinis, 1～3 part on Flos Carthami, 1.5～3 parts in Semen Persicae; 1～3 part of Radix Polygalae, 3～5 parts of Radix Semiaquilegiaes, 2～3 parts of Radix Clematidis, 1～3 part of Rhizoma Chuanxiong.
In order to reach better therapeutic, medicine of the present invention also adds following weight portion on the basis of above-mentioned component: 1～3 part in Rhizoma Gastrodiae, 1～4 part of Ramulus Uncariae Cum Uncis, 1～3 part of Scorpio; 0.8～1.8 part of Scolopendra, 1～3 part of Zaocys, 1～3 part of Eupolyphaga Seu Steleophaga, 3～10 parts of the Radixs Astragali, 1～3 part of Radix Notoginseng; 1～4 part of Olibanum, 1.5～5 parts of Myrrhas, triangular 1.5～3 parts, 1.5～3 parts of Rhizoma Curcumae; 2～3 parts of the Cortexs Eucommiae, 1.5～3 parts of Radix Achyranthis Bidentataes, 0.5～3 part in Radix Glycyrrhizae, 3～5 parts of Caulis Spatholobis.
The method for preparing of medicine of the present invention is: the effective ingredient that extracts medicine of the present invention earlier with the conventional method of Chinese medicine preparation; Again the effective ingredient that extracts is added conventional adjuvant; Be prepared into any dosage form for oral administration commonly used like disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, like pill, powder, tablet, capsule, oral liquid etc.
The concrete method for preparing of medicine of the present invention comprises the steps:
1. get the raw materials ready: get all the respectively distinguish the flavor of raw material of Chinese medicine and corresponding auxiliary material ready by the prescription consumption;
2. decoct: each crude drug decocte with water twice that will be except that Herba Asari, amount of water was not advisable to have powder at every turn, after boiling with high heat; Reuse slow fire infusion 60～80 minutes merges decocting liquid twice, crosses to filter filtrating; Be condensed into proportion and be 1.35 extractum, add 90～95% ethanol and carry out alcohol and get, reclaim ethanol and concentrate; Dry under 45～50 ℃, make extractum 1;
3. extractum 1 is ground into fine powder, Herba Asari is extracted volatile oil, and, be the effective ingredient of medicine of the present invention after Herba Asari volatile oil that extracts and the extractum 1 fine powder mixing and stirring with steam distillation or water-boiling method.
4. will add different pharmaceutical adjuncts through the effective ingredient of the present invention that 3. step obtains, just can make the medicine of the present invention of required different dosage form with the Chinese medicine conventional method.Like capsule, tablet, powder or oral liquid.
Medicine of the present invention has suppressing the hyperactive liver to relieve the wind syndrome, blood circulation promoting and blood stasis dispelling, and the function of mending the rigidity of soft tissues muscle is used to treat cerebral thrombosis, cerebrovascular sclerosis and apoplectic hemiplegia.
[specific embodiment]
One, following through medicament capsule treatment cerebral thrombosis of the present invention and cerebrovascular sclerosis and the next further proof of apoplectic hemiplegia 108 clinical observations beneficial effect of the present invention.
1, physical data:
Accept out-patient's totally 108 examples for medical treatment, male's 73 examples wherein, women's 35 examples, 50～60 years old 20 age example, 60～70 years old 65 example, 23 examples more than 70 years old, wherein professional cadre 60 people, teacher 25 people, workman 15 people, driver 8 people.
2, diagnostic criteria: according to patient's pulse condition; Tongue fur and hospital carry out electroencephalogram, scanning, nuclear-magnetism and ultrasound diagnosis result to the patient, confirm as half body meridian function obstacle person: like apoplexy, hemiplegia, part dizziness, trigeminal neuralgia, aphasis, mouthful oblique, myasthenia of limbs, walking disorder person.
3, Therapeutic Method: oral three times of every day, each 3～5, obeyed altogether 10 days, the patient think satisfied after, continued again to take 3～6 months, severe patient need be taken medicine 1 year.
4, efficacy assessment standard: complete: condition of illness all disappears, and walking is lived and can be taken care of oneself freely, recurrence after half a year;
Produce effects: condition of illness disappears basically, can walk, and life is taken care of oneself basically, but walking can't resemble the normal person freely;
Effectively: condition of illness takes a turn for the better to some extent, and language function is normal basically, can hold up and stand, and leans on crutch slowly to walk, but can't reach degree freely;
Invalid: the state of an illness is not improved, and symptom does not take a turn for the better.
5, therapeutic outcome: treat after 3～6 months and observe
Complete: 61 people account for 56.5%; Produce effects: 32 people account for 29.6%; Effectively: 9 people account for 8.3%; Invalid: 6 people account for 5.6%.Total effective rate 94.4%.
Two, followingly further specify method for preparing of the present invention through embodiment
Embodiment 1: dragon gives birth to capsular method for preparing:
1. with LUMBRICUS 9g, Hirudo 1.5g, Radix Salviae Miltiorrhizae 9g, Ramulus Cinnamomi 9g, windproof 15g, Plumula Nelumbinis 1.5g, Flos Carthami 10g, Semen Persicae 9g, Radix Polygalae 10g, Radix Semiaquilegiae 9g, Radix Clematidis 6g, Rhizoma Chuanxiong 3g, and Rhizoma Gastrodiae 9g, Ramulus Uncariae Cum Uncis 12g, Scorpio 9g, Scolopendra 2.5g, Zaocys 3g, Eupolyphaga Seu Steleophaga 3g, Radix Astragali 9g, Radix Notoginseng 9g, Olibanum 3g, Myrrha 15g, triangular 4.5g, Rhizoma Curcumae 4.5g, Cortex Eucommiae 6g, Radix Achyranthis Bidentatae 4.5g, Radix Glycyrrhizae 1.5g, Caulis Spatholobi 9g; Twice of decocte with water; Each amount of water was not advisable to have powder; Merge decocting liquid twice, cross and to filter filtrating 1, be condensed into proportion and be 1.35 extractum; Add 90～95% ethanol and carry out precipitate with ethanol; Reclaim ethanol and concentrated, dry under 45～50 ℃, make the extractum medicine;
2. Herba Asari 4g is used steam distillation, be extracted into volatile oil, for use;
3. merge extractum 1 and volatile oil, its pulverizing is mixed thoroughly, the snap fit capsule of packing into.
Embodiment 2: the preparation tablets of medicine of the present invention
1. take by weighing each crude drug by following reprovision ratio: LUMBRICUS 4.5g, Hirudo 3g, Radix Salviae Miltiorrhizae 15g, Ramulus Cinnamomi 3g, windproof 5g, Herba Asari 1g, Plumula Nelumbinis 3g, Flos Carthami 3g, Semen Persicae 4.5g, Radix Polygalae 3g, Radix Semiaquilegiae 15g, Radix Clematidis 9g, Rhizoma Chuanxiong 9g, and Rhizoma Gastrodiae 3g, Ramulus Uncariae Cum Uncis 3g, Scorpio 3g, Scolopendra 5g, Zaocys 9g, Eupolyphaga Seu Steleophaga 9g, Radix Astragali 30g, Radix Notoginseng 3g, Olibanum 12g, Myrrha 5g, triangular 9g, Rhizoma Curcumae 9g, Cortex Eucommiae 9g, Radix Achyranthis Bidentatae 9g, Radix Glycyrrhizae 9g, Caulis Spatholobi 15g;
2. each raw material of Chinese medicine decocte with water twice that will be except that Herba Asari, each amount of water was not advisable to have powder 2cm, and first intense fire boils, and slow fire boiled 60～80 minutes again, merged decocting liquid twice, crossed to filter filtrating 1;
3. Herba Asari is added the conventional decoction twice of 3 times of amounts of water, it is for use to collect volatile oil, and water cooking liquid is for use;
4. merge filtrate and Herba Asari water cooking liquid, be condensed into proportion and be 1.35 extractum, extractum is added 90～95% ethanol, stir, deposition reclaims ethanol and concentrates, 45～50 ℃ dry down, it is for use to make dry extract;
5. the extract powder that makes is broken into fine powder, adds adjuvant and process granule and dry, spray into Herba Asari volatile oil, compacting in flakes.
Claims (4)
1. medicine of treating cerebral thrombosis, cerebrovascular sclerosis and apoplectic hemiplegia, it is characterized in that: it is processed by following bulk drugs: LUMBRICUS 1.5-3 part, Hirudo 0.5-1 part, Radix Salviae Miltiorrhizae 3-5 part; Ramulus Cinnamomi 1-3 part, windproof 1.5-5 part, Herba Asari 0.3-1.3 part, Plumula Nelumbinis 0.5-1 part; Flos Carthami 1-3 part, Semen Persicae 1.5-3 part, Radix Polygalae 1-3 part; Radix Semiaquilegiae 3-5 part, Radix Clematidis 2-3 part, Rhizoma Chuanxiong 1-3 part.
2. medicine of treating cerebral thrombosis, cerebrovascular sclerosis and apoplectic hemiplegia, it is characterized in that: it is processed by following bulk drugs: LUMBRICUS 1.5-3 part, Hirudo 0.5-1 part, Radix Salviae Miltiorrhizae 3-5 part, Ramulus Cinnamomi 1-3 part; Windproof 1.5-5 part, Herba Asari 0.3-1.3 part, Plumula Nelumbinis 0.5-1 part, Flos Carthami 1-3 part, Semen Persicae 1.5-3 part; Radix Polygalae 1-3 part, Radix Semiaquilegiae 3-5 part, Radix Clematidis 2-3 part, Rhizoma Chuanxiong 1-3 part, Rhizoma Gastrodiae 1-3 part; Ramulus Uncariae Cum Uncis 1-4 part, Scorpio 1-3 part, Scolopendra 0.8-1.8 part, Zaocys 1-3 part, Eupolyphaga Seu Steleophaga 1-3 part; Radix Astragali 3-10 part, Radix Notoginseng 1-3 part, Olibanum 1-4 part, Myrrha 1.5-5 part, triangular 1.5-3 part; Rhizoma Curcumae 1.5-3 part, Cortex Eucommiae 2-3 part, Radix Achyranthis Bidentatae 1.5-3 part, Radix Glycyrrhizae 0.5-3 part, Caulis Spatholobi 3-5 part.
3. the method for preparing of claim 1 or 2 said medicines, it is characterized in that: it comprises the following steps:
1. it is subsequent use to take by weighing each crude drug;
2. with each the crude drug decocte with water twice beyond the Herba Asari, each amount of water did not have powder, merged decocting liquid twice; Cross and filter filtrating 1, be condensed into proportion and be 1.35 extractum, add 90%-95% ethanol and carry out precipitate with ethanol; Reclaim ethanol and concentrated, dry under 45-50 ℃, make extractum 1;
3. Herba Asari water steam distillation method or decocting cooking method are extracted Herba Asari volatile oil, for use;
4. pulverize extractum 1 and mix and mix thoroughly, just processed the effective ingredient of this medicine with Herba Asari volatile oil.
4. method for preparing according to claim 3 is characterized in that: wherein at effective ingredient that 4. step makes with after the conventional Chinese medicine pharmaceutical adjunct mixes, process the different dosage form of this medicine.
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Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396525B (en) * | 2008-10-18 | 2011-04-13 | 郭晓红 | Traditional Chinese medicine preparation for treating cerebrovascular disease |
| CN101632732B (en) * | 2009-08-25 | 2011-10-26 | 刘卫丽 | Medicine for treating cerebrovascular diseases |
| CN102423437B (en) * | 2011-12-27 | 2014-04-02 | 峨眉山天梁星制药有限公司 | Double-prescription medicament for treating apoplectic hemiplegia and preparation method thereof |
| CN102764381B (en) * | 2012-08-13 | 2014-09-17 | 黄永阳 | Traditional Chinese medicine composite for curing cerebral infarction sequelae |
| CN104258221A (en) * | 2014-10-17 | 2015-01-07 | 乔世琴 | Traditional Chinese medicine composition for treating blood stasis channel blocking type cerebral embolism and preparation method of composition |
| CN104984268A (en) * | 2015-08-10 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Traditional Chinese medicine composition treating cerebral thrombosis and preparing method of traditional Chinese medicine composition |
| CN105055816A (en) * | 2015-08-25 | 2015-11-18 | 崔新明 | Traditional Chinese medicine composite for treating cerebral thrombosis and preparation method thereof |
| CN105902771A (en) * | 2015-08-25 | 2016-08-31 | 烟台市蓝洋之草医药生物科技有限公司 | Application of traditional Chinese medicine composition in preparation of medicines for treating cerebral thrombosis |
| CN105250734A (en) * | 2015-10-28 | 2016-01-20 | 蒋玉群 | Traditional Chinese medicine composition for treating cerebral arterial thrombosis |
| CN106539893A (en) * | 2016-09-21 | 2017-03-29 | 深圳市得道中医馆管理有限责任公司 | A kind of application of Chinese medicine composition and preparation method thereof and treatment cerebrovascular sclerosiss |
| CN107158179A (en) * | 2017-04-11 | 2017-09-15 | 张拴芹 | Chinese patent drug bulk powder |
| CN108465073A (en) * | 2018-06-27 | 2018-08-31 | 孟胜喜 | Treat the Chinese medicine composition and its preparation method and application of Posterior circulation ischemia dizziness |
| CN109731084A (en) * | 2019-03-25 | 2019-05-10 | 哈尔滨医科大学 | A kind of Chinese medicine composition for treating apoplexy cerebral infarction |
| CN111701000A (en) * | 2020-07-24 | 2020-09-25 | 王广印 | Traditional Chinese medicine preparation for treating thrombus hemiplegia |
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| CN1336225A (en) * | 2001-08-21 | 2002-02-20 | 徐凤玉 | Cerebral thrombus treating traditional Chinese medicine |
| CN1686510A (en) * | 2005-04-14 | 2005-10-26 | 赵宏伟 | Ready prepared Chinese medicine for preventing and treating brain apoplexia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1336225A (en) * | 2001-08-21 | 2002-02-20 | 徐凤玉 | Cerebral thrombus treating traditional Chinese medicine |
| CN1686510A (en) * | 2005-04-14 | 2005-10-26 | 赵宏伟 | Ready prepared Chinese medicine for preventing and treating brain apoplexia |
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