CN108465073A - Treat the Chinese medicine composition and its preparation method and application of Posterior circulation ischemia dizziness - Google Patents
Treat the Chinese medicine composition and its preparation method and application of Posterior circulation ischemia dizziness Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses a kind of Chinese medicine composition for treating Posterior circulation ischemia dizziness, the Chinese medicine composition is prepared by the raw material including following parts by weight：15 25 parts of Rhizoma Gastrodiae, 15 25 parts of uncaria, 8 12 parts of Rhizoma Chuanxiong, 10 15 parts of Radix Salviae Miltiorrhizae, 10 15 parts of pueraria lobata, 15 30 parts of Caulis Spatholobi, 5 10 parts of trigone, 13 parts of leech, 48 parts of earthworm.Above-mentioned Chinese medicine composition can significantly improve the clinical symptoms of Posterior circulation ischemia patients with vertigo, it is horizontal to reduce plasma fibrinogen, D D dimers and blood viscosity, improve patient's vertebrobasilar insufficiency, reduce serum D D and FIB level and atherogenic index, curative effect is substantially better than Western medicine, and without obvious toxic-side effects.The invention also discloses the preparation methods of above-mentioned Chinese medicine composition, and this method is simple and easy to do, preparation easy to produce, can extract the active ingredient of each drug component to greatest extent.
Description
Technical field
The present invention relates to traditional Chinese medicine technical fields, and in particular to a kind of Chinese medicine composition for treating Posterior circulation ischemia dizziness
And its preparation method and application.
Background technology
The transient cerebral ischemia that Posterior circulation ischemia (posteriorcirculationischemia, PCI) recycles after referring to
Breaking-out (TIA) and cerebral infarction.Study of Etiology discovery is carried out to all patients for being chief complaint medical with dizziness, PCI is after benign
The second cause of disease after paroxysmal positional vertigo.The principal causative mechanism of PCI is atherosclerosis, hemadostewnosis and is closed
Plug, rear to recycle haemodynamics obstacle, cerebral hyoperfusion causes ischaemic, and then anoxic occurs and cause dizziness.Fibrin
The generation, development of blood viscosity index and systemic atherosclerosis, lesion degree are closely related in proteinogen, hemorheology.
Posterior circulation ischemia dizziness belongs to motherland's medicine " dizziness " scope, this disease disease position in brain key, lesion internal organs and liver,
Kidney is related.The interpretation of the cause, onset and process of an illness is mainly liver-kidney Yin deficiency, and water files to nourish wood, and the moon does not tie up sun, and YANG overacting in the uppper part or the fiery liter of gas, attacking up head and eyes are then sent out
For dizziness.The pharmaceutical admixtures of clinical treatment Posterior circulation ischemia dizziness still lack unified standard at present, and expection is often not achieved
Effect, and have a degree of side effect to human body, seeking curative for effect and few side effects therapies has important meaning
Justice.
Invention content
It is existing to solve the purpose of the present invention is to provide a kind of Chinese medicine composition for treating Posterior circulation ischemia dizziness
The pharmaceutical admixtures for the treatment of Posterior circulation ischemia dizziness still lack unified standard, often fall flat, and have to human body
The problem of a degree of side effect.
To achieve the above object, the technical scheme is that：
A kind of Chinese medicine composition for treating Posterior circulation ischemia dizziness, the Chinese medicine composition is by including following parts by weight
Raw material be prepared：15-25 parts of Rhizoma Gastrodiae, 15-25 parts of uncaria, 8-12 parts of Rhizoma Chuanxiong, 10-15 parts of Radix Salviae Miltiorrhizae, 10-15 parts of pueraria lobata, chicken
15-30 parts of blood rattan, 5-10 parts of trigone, 1-3 parts of leech, 4-8 parts of earthworm.
As a preferred solution, the Chinese medicine composition is prepared by the raw material including following parts by weight：It
20 parts of fiber crops, 20 parts of uncaria, 10 parts of Rhizoma Chuanxiong, 13 parts of Radix Salviae Miltiorrhizae, 13 parts of pueraria lobata, 22 parts of Caulis Spatholobi, 8 parts of trigone, 2 parts of leech, earthworm 6
Part.
As a preferred solution, the Chinese medicine composition further includes 7-8 parts of Radix Astragali, 7-8 parts of Rhizoma Atractylodis Macrocephalae, simultaneous for treating
See the patient of deficiency of vital energy symptom.
As a preferred solution, the Chinese medicine composition further includes 4-5 parts of radix bupleuri, 4-5 parts of Fructus Aurantii, simultaneous for treating
See the patient of stagnation of the circulation of vital energy symptom.
As a preferred solution, the Chinese medicine composition further includes 1-2 parts of Chinese cassia tree, 7-8 parts of Longstamen Onion Bulb, for treating partially
In the patient of cold solidifying symptom.
As a preferred solution, the Chinese medicine composition further includes 4-5 parts of the tuber of pinellia, 4-5 parts of dried orange peel, simultaneous for treating
See the patient of the turbid symptom of phlegm.
Second object of the present invention is to provide a kind of Chinese traditional medicine composition for the treatment of Posterior circulation ischemia dizziness as described above
The preparation method of object, the preparation method include the following steps：
Step 1：Weigh each raw material of corresponding parts by weight；
Step 2：Other each raw materials in addition to earthworm are placed in medicine pot, suitable water is added and impregnates 10-30 minutes；
Step 3：Big fire boils 10-25 minutes；Turn small fire, continues tanning 10-25 minutes；
Step 4：Flame-out, filter and remove residue obtains filtrate；
Step 5：The earthworm dried is pulverized, is added in filtrate obtained by step 4, after stirring evenly up to treating
The Chinese medicine composition of circulation ischemia dizziness.
As a preferred solution, in step 2, the total weight ratio of the water of addition and each Chinese medicine material is 4:1-10:1.
Third object of the present invention is to provide a kind of Chinese medicine composition as described above, circulation ischemia is dizzy after the treatment
Application in dizzy drug.
The pharmacology of the main component of above-mentioned Chinese medicine composition is as follows：
Rhizoma Gastrodiae is sweet flat, calming the liver to stop the wind, is monarch drug in a prescription；Uncaria sweetness and bitterness is slightly cold, The flat liver of heat-clearing, relieving convulsion and spasm, is ministerial drug；Rhizoma Chuanxiong is pungent
Temperature, Radix Salviae Miltiorrhizae hardship are slightly cold, and pueraria lobata is sweet pungent cool, and Caulis Spatholobi bitter sweet temperature can be promoting blood circulation and removing blood stasis；Trigone is arduous flat, and leech is salty bitter flat, has broken
Blood is by stasis of blood effect；Earthworm it is salty-cold enter network, can heat-clearing, antispastic, dredging collateral, above all medicines altogether be adjutant.
Improve cerebral ischemia modern pharmacological studies have shown that Rhizoma Gastrodiae has, mitigate vertigo symptoms, improve glycolipid metabolism, reduce blood
The effects that pressure.Uncaria principle active component rhynchophyllin has antithrombus formation, anticoagulation, antiplatelet aggregative activity.Rhizoma Chuanxiong
Active ingredient ferulic acid has platelet aggregation-against, the release of inhibition platelet 5-HT, inhibition platelet thrombus element generation etc.
Effect, another active ingredient ligustrazine can improve microcirculation, protection nerve, inhibit ischemical reperfusion injury.Radix Salviae Miltiorrhizae effectively at
Divide polydanshinolate promoting blood circulation and removing blood stasis, improve microcirculation, Anhydroalkannin, anti-bolt, anti-oxidant, removing free radical, inhibition Endothelin are released
Put, improve ischemical reperfusion injury etc., vascular endothelial cell defencive function also can be improved, improve blood rheology parameter.Pueraria lobata
With antioxidation, microcirculation can be improved to blood glucose and blood pressure bidirectional modulation by improving immunity of organisms.Caulis Spatholobi, trigone,
Leech has the effects that inhibit platelet aggregation, antioxidation, antitumor.Earthworm can anti-freezing, thrombolysis, adjust immune, expansion
Blood vessel, improvement microcirculation, decompression, lipid-loweringing etc..
For Posterior circulation ischemia dizziness, this Chinese medicine composition can obviously improve the symptoms such as the dizziness of patient, improve vertebra base
Bottom artery flow velocity reduces serum plasma fibrinogen, D-D dimer and blood viscosity level and atherogenic index,
And safety is higher.
The invention has the advantages that：
The present invention is based on the Chinese medicine differentiation of disease with the dialectical principle being combined, and filters out the day with soothing the liver, promoting blood circulation, dredging collateral effect
Right drug is formed according to certain weight proportion, after providing a kind for the treatment of significant in efficacy, of low cost, toxic side effect is small
The Chinese medicine composition of circulation ischemia dizziness.
Chinese medicine composition provided by the invention can significantly improve the clinical symptoms of Posterior circulation ischemia patients with vertigo, drop
Low plasma fibrinogen, D-D dimer and blood viscosity are horizontal, improve patient's vertebral-basilar artery insufficiency, reduce serum
D-D and FIB is horizontal and atherogenic index, curative effect are substantially better than Western medicine, and without obvious toxic-side effects.
The preparation method of above-mentioned Chinese medicine composition disclosed by the invention is simple and easy to do, and preparation easy to produce can be to greatest extent
Extract the active ingredient of each drug component.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：20 grams of Rhizoma Gastrodiae, 20 grams of uncaria, 10 grams of Rhizoma Chuanxiong, 13 grams of Radix Salviae Miltiorrhizae, 13 grams of pueraria lobata, chicken blood
22 grams of rattan, 8 grams of trigone, 2 grams of leech, 6 grams of earthworm.
The preparation method of above-mentioned Chinese medicine composition is as follows：
Step 1：Weigh each raw material of corresponding weight grams；
Step 2：Other each raw materials in addition to earthworm are placed in medicine pot, suitable water is added and impregnates 20 minutes；
Step 3：Big fire boils 22 minutes；Turn small fire, continues tanning 22 minutes；
Step 4：Flame-out, filter and remove residue obtains filtrate；
Step 5：The earthworm dried is pulverized, is added in filtrate obtained by step 4, after stirring evenly up to treating
The Chinese medicine composition of circulation ischemia dizziness.
In step 2, the total weight ratio of the water of addition and each Chinese medicine material is 7:1.
Embodiment 2
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：15 grams of Rhizoma Gastrodiae, 25 grams of uncaria, 8 grams of Rhizoma Chuanxiong, 15 grams of Radix Salviae Miltiorrhizae, 10 grams of pueraria lobata, Caulis Spatholobi
30 grams, 5 grams of trigone, 3 grams of leech, 4 grams of earthworm.
The preparation method of above-mentioned Chinese medicine composition is as follows：
Step 1：Weigh each raw material of corresponding weight grams；
Step 2：Other each raw materials in addition to earthworm are placed in medicine pot, suitable water is added and impregnates 10 minutes；
Step 3：Big fire boils 10 minutes；Turn small fire, continues tanning 10 minutes；
Step 4：Flame-out, filter and remove residue obtains filtrate；
Step 5：The earthworm dried is pulverized, is added in filtrate obtained by step 4, after stirring evenly up to treating
The Chinese medicine composition of circulation ischemia dizziness.
In step 2, the total weight ratio of the water of addition and each Chinese medicine material is 4:1.
Embodiment 3
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：25 grams of Rhizoma Gastrodiae, 15 grams of uncaria, 12 grams of Rhizoma Chuanxiong, 10 grams of Radix Salviae Miltiorrhizae, 15 grams of pueraria lobata, chicken blood
15 grams of rattan, 10 grams of trigone, 1 gram of leech, 8 grams of earthworm.
The preparation method of above-mentioned Chinese medicine composition is as follows：
Step 1：Weigh each raw material of corresponding weight grams；
Step 2：Other each raw materials in addition to earthworm are placed in medicine pot, suitable water is added and impregnates 30 minutes；
Step 3：Big fire boils 25 minutes；Turn small fire, continues tanning 25 minutes；
Step 4：Flame-out, filter and remove residue obtains filtrate；
Step 5：The earthworm dried is pulverized, is added in filtrate obtained by step 4, after stirring evenly up to treating
The Chinese medicine composition of circulation ischemia dizziness.
In step 2, the total weight ratio of the water of addition and each Chinese medicine material is 10:1.
Embodiment 4
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：15 grams of Rhizoma Gastrodiae, 25 grams of uncaria, 8 grams of Rhizoma Chuanxiong, 15 grams of Radix Salviae Miltiorrhizae, 10 grams of pueraria lobata, Caulis Spatholobi
30 grams, 5 grams of trigone, 3 grams of leech, 4 grams of earthworm.
The Chinese medicine composition further includes 8 grams of Radix Astragali, 7 grams of Rhizoma Atractylodis Macrocephalae.
Preparation method and embodiment 1 are identical.
Embodiment 5
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：25 grams of Rhizoma Gastrodiae, 15 grams of uncaria, 12 grams of Rhizoma Chuanxiong, 10 grams of Radix Salviae Miltiorrhizae, 15 grams of pueraria lobata, chicken blood
15 grams of rattan, 10 grams of trigone, 1 gram of leech, 8 grams of earthworm.
The Chinese medicine composition further includes 7 grams of Radix Astragali, 8 grams of Rhizoma Atractylodis Macrocephalae.
Preparation method and embodiment 1 are identical.
Embodiment 6
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：15 grams of Rhizoma Gastrodiae, 25 grams of uncaria, 8 grams of Rhizoma Chuanxiong, 15 grams of Radix Salviae Miltiorrhizae, 10 grams of pueraria lobata, Caulis Spatholobi
30 grams, 5 grams of trigone, 3 grams of leech, 4 grams of earthworm.
The Chinese medicine composition further includes 5 grams of radix bupleuri, 4 grams of Fructus Aurantii.
Preparation method and embodiment 1 are identical.
Embodiment 7
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：25 grams of Rhizoma Gastrodiae, 15 grams of uncaria, 12 grams of Rhizoma Chuanxiong, 10 grams of Radix Salviae Miltiorrhizae, 15 grams of pueraria lobata, chicken blood
15 grams of rattan, 10 grams of trigone, 1 gram of leech, 8 grams of earthworm.
The Chinese medicine composition further includes 4 grams of radix bupleuri, 5 grams of Fructus Aurantii.
Preparation method and embodiment 1 are identical.
Embodiment 8
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：15 grams of Rhizoma Gastrodiae, 25 grams of uncaria, 8 grams of Rhizoma Chuanxiong, 15 grams of Radix Salviae Miltiorrhizae, 10 grams of pueraria lobata, Caulis Spatholobi
30 grams, 5 grams of trigone, 3 grams of leech, 4 grams of earthworm.
The Chinese medicine composition further includes 2 grams of Chinese cassia tree, 7 grams of Longstamen Onion Bulb.
Preparation method and embodiment 1 are identical.
Embodiment 9
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：25 grams of Rhizoma Gastrodiae, 15 grams of uncaria, 12 grams of Rhizoma Chuanxiong, 10 grams of Radix Salviae Miltiorrhizae, 15 grams of pueraria lobata, chicken blood
15 grams of rattan, 10 grams of trigone, 1 gram of leech, 8 grams of earthworm.
The Chinese medicine composition further includes 1 gram of Chinese cassia tree, 8 grams of Longstamen Onion Bulb.
Preparation method and embodiment 1 are identical.
Embodiment 10
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：15 grams of Rhizoma Gastrodiae, 25 grams of uncaria, 8 grams of Rhizoma Chuanxiong, 15 grams of Radix Salviae Miltiorrhizae, 10 grams of pueraria lobata, Caulis Spatholobi
30 grams, 5 grams of trigone, 3 grams of leech, 4 grams of earthworm.
The Chinese medicine composition further includes 5 grams of the tuber of pinellia, 4 grams of dried orange peel.
Preparation method and embodiment 1 are identical.
Embodiment 11
The present embodiment provides a kind of Chinese medicine compositions for treating Posterior circulation ischemia dizziness, and the Chinese medicine composition is by including
The raw material of following weight grams is prepared：25 grams of Rhizoma Gastrodiae, 15 grams of uncaria, 12 grams of Rhizoma Chuanxiong, 10 grams of Radix Salviae Miltiorrhizae, 15 grams of pueraria lobata, chicken blood
15 grams of rattan, 10 grams of trigone, 1 gram of leech, 8 grams of earthworm.
The Chinese medicine composition further includes 4 grams of the tuber of pinellia, 5 grams of dried orange peel.
Preparation method and embodiment 1 are identical.
Effect test：
Satisfied curative effect is achieved using traditional Chinese medicine composition for treating Posterior circulation ischemia dizziness described in embodiment 1, specifically
It is as follows.
1 data and method
1.1 general information
The case of this research is in December, 2015~2017 year The 6th Hospital of Shanghai Jiao Tong University in December
Department of traditional Chinese medicine Posterior circulation ischemia patients with vertigo, is included in 168 altogether, vertigo attack is shown as when medical, with tinnitus symptom, through super
Acoustic inspection shows that unilateral or bilateral vertebral-basilar artery blood flow velocity occurs and slows down symptom.It is randomly divided into according to random digits table
Control group 84 and treatment group 84.Two groups of patient baseline's data are comparable, and there was no significant difference, equal P ＞ 0.05.It is shown in Table
1。
1 each group patient's general information of table
1.2 diagnostic criteria, inclusion criteria and exclusion criteria
Diagnostic criteria
Reference《The Consensus of experts of Chinese Posterior circulation ischemia》Determining diagnostic criteria：Age >=45 year old；The ictal object that regards revolves
Turn or rocks, sense of drifting along；Recurrent exerbation, Chang Yutou, Body Position Change or anxiety, fatigue are related；Dizziness after one kind at least with following
Ring ischemia symptom, such as diplopia, Hearing, cough of choking, damping off, extremity numbness or disequilibrium；With or without brain stem or corpus cerebelli
Sign；Except dizziness caused by external ear source property disease and other systems disease.
Inclusion criteria
Meet diagnostic criteria；Previously there are the medical histories such as artery sclerosis, blood-lipid imbalance disease, hypertension；Based on episodic vertigo
Symptom is wanted, mostly induces or aggravates because of the variation of position, is fainted with tinnitus, Nausea and vomiting or suddenly；It can be transient with brain stem
Ischemia symptom, such as the headache of blindness, diplopia, extremity numbness, rear pillow part；Transcranial Doppler ultrasound (TCD) and cranium brain, neck CT or
MRI, which is checked, to be confirmed.
Exclusion criteria
There are incomplete serious cardiorenal function, contrast medium sensitivity, family members not to sign the normal patient of informed consent form, TCD.
1.3 therapy
Two groups of patients of Primary Care do not use the treatments such as expansion blood vessel, anticoagulant before entering group, receive basis after entering group
Treatment：Less salt low fat diet, wine for giving off smoking are lain up, and are prevented from falling down, be got injured by a fall, acousto-optic is avoided to stimulate, and excitement and spirit thorn are avoided
Swash.25~50mg of 10mg or phenergan is stabilized in calm, antiemetic when vertigo attack, intramuscular injection, and serious vomiter supplements water and electrolyte,
Maintain patient's water, electrolyte, acid-base balance.Complication with diabetes person gives glucose-lowering treatment, and merging essential hypertension person, which gives, to drop
Pressure treatment.
Control group：Give Western medicine Betahistine Mesylate (trade name：Betahistine, authentication code：Chinese medicines quasi-word
41032000H, lot number：1706105, manufacturing enterprise：Pharmaceutical Co., Ltd. of health material), 1 time 1~2 (6~12mg), 3 times/d, meal
After take orally.
Treatment group：Give Western medicine Betahistine Mesylate, 1 time 1~2 (6~12mg), 3 times/d, oral meal.Simultaneously
Add Chinese medicine composition described in embodiment 1.All medicinal materials derive from Shanghai City Sixth People's Hospital Chinese medicine pharmacy.Usage：It will
Other each raw materials in addition to earthworm are boiled into decoction of medicinal ingredients, and the earthworm dried is pulverized, is flushed in decoction of medicinal ingredients and takes；It is daily 1 dose, early
Late sub-service.Two groups of courses for the treatment of are 8 weeks.Refuse to obey with other Chinese medicines and Chinese patent drugs for treatment during treatment.
1.4 statistical analysis
Data are handled using 11.5 statistical softwares of SPSS.Continuous data is indicated using mean ± standard deviation (x ± s), is treated
Front and back comparison uses paired t-test, each comparison among groups to use one-way analysis of variance.Enumeration data is indicated with rate (%), between group
Compare and uses X2It examines.P ＜ 0.05 are the standard of significant difference.
2 observation index and criterion of therapeutical effect
Symptom improves situation, Vertebral-basilar artery blood flow, blood viscosity and atherogenic index (AI) after 2.1 two groups of treatments.
Vertigo symptoms scale score is carried out before and after treatment and evaluates dizziness degree, including astasia, spinning sensation, tumble become
Gesture, rock sense, sense of jolting, position change cause dizziness and 7 aspects of breaking out suddenly, according to symptom degree without, it is slight, compared with
Weight is seriously calculated as 0,1,2,3 point respectively.
In before and after treatment using high frequency color Doppler ultrasound diagnostic equipment GE Logiq S6, frequency 5-13MHz.Detection
Bilateral vertebral artery and basal arteries mean blood flow velocity.Patient takes dorsal position after head, and room temperature is answered constant at 24 DEG C or so when inspection,
Head is biased to about 45 ° of offside when checking a bilateral common carotid artery.Probe is moved towards along chest lock mamillary process muscle outer edge arteria carotis, mobile vertical from bottom to top
It is rotated by 90 ° after cutting scanning, crosscutting scanning is done along blood vessel traveling, always moved from long axis and each section detection Bilateral Cervical of short axle respectively
Arteries and veins, arteria carotis communis crotch, internal carotid and external carotid artery.All cases by ultrasound medicine section of the court in being fixed before and after treatment
Senior doctor's detection.
Hemorheology is detected using Hitachi's HITACHI 7600-120 automatic clinical chemistry analyzers in pretherapy and post-treatment application
Index (whole blood viscosity height cut, whole blood viscosity undercut, Plasma Viscosity), cholesterol detection (TC), triacylglycerol (TG).All patients
Upper limb peripheric venous blood 6ml, separation sample test serum d-dimer (D-D), fiber egg are acquired after pretherapy and post-treatment empty stomach 8h
White original (FIB).D-D detections use immunoturbidimetry, 0.0~0.5mg/L of reference value；FIB detections use Clauss methods, reference value
2.0~4.0g/L.It assists to complete by clinical laboratory of the court above.
In before and after treatment using dizziness assessment marking scales (DARS) scoring, dizziness Disorder Inventory (DHI) overall score pair
Patient's dizziness degree is evaluated, and obstacle assessment scale (DHI) is that most widely used one kind is obtained in current clinical practice is symptomatic
Assessment judges the severity of dizziness according to testing and assessing point.It is 0~100 point that DHI combined index model dizziness, which is enclosed, is commented from whole
Estimate the severity of dizziness subjective symptom, wherein 0~30 point is mile abnormality, 31~60 points are moderate abnormality, and ＞ 60 divides for weight
It spends exception and has fall risk.
DARS is divided into 0~6 seven grades according to dizziness degree from light to heavy, and 6 points, dizziness is most heavy；DHI totally 25 problems,
Functional status, psychological condition including patient and three aspect content of physiological status, 0~100 point of gross score, score is higher, dizziness
Degree is heavier, more low, influences lighter.
The evaluation of nervous function：All patients are before and after treatment by full-time Neurology doctor using the dizzy evaluation quantity in Europe
Table (EEV) assesses its nervous function.
Atherogenic index (atheroscle-index, AI)：Two groups are consolidated respectively at each total courage of serum that measures before and after treatment
Alcohol and high-density lipoprotein, according to calculation formula：Atherogenic index=(one high-density lipoprotein of serum total cholesterol)/highly dense
Lipoprotein is spent, atherogenic index is calculated, statistical result is simultaneously compared.
Monitor therapeutic process in drug adverse reaction, before and after treatment detect blood routine, routine urinalysis, liver function, renal function,
Electrocardiogram.
2.2 criterion of therapeutical effect
Reference《New Chinese medicine guideline of clinical investigations》Middle relevant criterion is evaluated.
It cures：Dizziness is alleviated, the secondary remission such as headache, Nausea and vomiting, nervous；Transcranial Doppler ultrasound prompts brain
Restoration of blood flow is normal.
It is effective：Dizziness is alleviated substantially, but still occasionally has breaking-out；Alleviate minor symptom part；Transcranial Doppler ultrasound prompts brain
Blood flow is obviously improved.
Effectively：Dizziness is controlled, but when have breaking-out, influence to live；Minor symptom makes moderate progress；Transcranial Doppler ultrasound
Cerebral blood flow (CBF) part is prompted to improve.
In vain：Dizziness is without improvement, still frequently breaking-out；Transcranial Doppler ultrasound prompts cerebral blood flow (CBF) without improvement.
Total effective rate=(recovery from illness+effective+effectively)/total number of cases
3 results
During drug administration, there is 1 nauseous abdominal distension in treatment group, and control group has 1 gastral cavilty portion discomfort, above to locate through suiting the medicine to the illness
After reason, symptom disappears, remaining is without significant discomfort.The pretherapy and post-treatment liver function of two groups of patients, renal function and electrocardiogram are without bright
Aobvious anomalous variation.
3.1 two groups of therapeutic levels compare
Table 2 shows that two groups of curative effects are more statistically significant, and treatment group's therapeutic level is apparently higher than control group (P ＜
0.05)。
2 two groups of curative effects of table compare [example (%)]
3.2 clinical symptoms improve situation comparison
After table 3 shows treatment, treatment group patient tinnitus symptom extinction time, vertigo symptoms extinction time are less than control
Group, difference are statistically significant (P ＜ 0.05).
3 two groups of clinical symptoms of table improve situation and compare (h, x ± s)
Note：Compared with the control group, #P ＜ 0.05
Table 4 shows that compared with before treatment, treatment group's vertigo symptoms scale score and pretherapy and post-treatment difference are substantially reduced,
Difference is statistically significant (equal P ＜ 0.05), and control group vertigo symptoms scale score also reduces, and difference is also statistically significant
(P ＜ 0.05).With compare, treatment group's vertigo symptoms scale score and pretherapy and post-treatment difference are substantially reduced, and difference has
Statistical significance (P ＜ 0.05).
4 two groups of vertigo symptoms scale scores of table compare and (divide, x ± s)
Note：With this group before treatment, * P ＜ 0.05；Compared with the control group, #P ＜ 0.05
Table 5 shows that compared with before treatment, treatment group's EEV and DHI score value is substantially reduced, statistically significant (the P ＜ of difference
0.05), the variation of control group dizziness EEV and DHI score value is little, no significant difference (P ＞ 0.05).With compare, control
Treatment group EEV and DHI score value is substantially reduced, and difference is statistically significant (P ＜ 0.05).
5 two groups of EEV and DHI score values of table compare and (divide, x ± s)
Note：With this group before treatment, * P ＜ 0.05；Compared with the control group, #P ＜ 0.05
3.3 two groups of plasma fibrinogens, D-D dimer and blood viscosity compare
Table 6 shows that compared with before treatment, plasma fibrinogen, D-D dimer and blood viscosity are equal after treatment group's treatment
It is substantially reduced, difference is statistically significant (P ＜ 0.05), the pretherapy and post-treatment plasma fibrinogen of control group, D-D dimer and blood
Liquid viscosity changes unobvious, no significant difference (P ＞ 0.05)；Compared with the control group, the plasma fibrin for the treatment of group
Former, D-D dimer and blood viscosity reduce significantly (P ＜ 0.05).
6 two groups of plasma fibrinogens of table and blood viscosity compare
Note:With this group before treatment, * P ＜ 0.05；Compared with the control group, #P ＜ 0.05
3.4 two groups of Vertebral-basilar artery blood flow variable elements compare
Table 7 shows that compared with before treatment, bilateral vertebral artery, basal arteries VPV obviously increase after treatment group's treatment
Soon, difference is statistically significant (P ＜ 0.05), and the pretherapy and post-treatment bilateral vertebral artery of control group, basal arteries VPV variation are not
Obviously, no significant difference (P ＞ 0.05)；After two groups of treatments, compared with the control group, bilateral vertebral artery, the base for the treatment of group
Bottom artery flow velocity increases significantly (P ＜ 0.05).
7 two groups of Vertebral-basilar artery blood flow variable elements of table compare (x ± s)
Note：With this group before treatment, * P ＜ 0.05；Compared with the control group, #P ＜ 0.05
3.5 two groups of atherogenic indexes compare
Table 8 shows that compared with before treatment, treatment group's treatment artery hardenability value is substantially reduced, and difference has statistics meaning
Adopted (P ＜ 0.05), control group treat artery hardenability value and change unobvious, no significant difference (P ＞ 0.05)；With it is right
Compare according to group, the atherogenic index for the treatment of group reduces significantly (P ＜ 0.05).
8 two groups of atherogenic indexes of table compare and (divide, x ± s)
Note：With this group before treatment, * P ＜ 0.05；Compared with the control group, #P ＜ 0.05
The studies above the result shows that, treatment group's total effective rate is 86.90%, and control group total effective rate only has 60.71%,
Treatment group's curative effect is substantially better than control group (P ＜ 0.05)；Chinese medicine composition provided by the invention can significantly improve patient clinical
Symptom reduces plasma fibrinogen, D-D dimer and blood viscosity level, improves patient's vertebral-basilar artery insufficiency,
Serum D-D and FIB level and atherogenic index are reduced, and its curative effect is substantially better than comparison medicine Betahistine.Therefore, the present invention carries
The Chinese medicine composition of confession has Posterior circulation ischemia dizziness notable curative effect, mechanism to may be by improving Vertebral-basilar artery blood
Flow velocity degree reduces serum plasma fibrinogen, D-D dimer and blood viscosity level and atherogenic index to realize.
In conclusion to Posterior circulation ischemia dizziness, Chinese medicine composition provided by the invention can obviously improve the dizzy of patient
The symptoms such as dizzy, improve vertebro-basilar artery blood flow velocity, reduce serum plasma fibrinogen, D-D dimer and blood viscosity water
Flat and atherogenic index, and safety is higher.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention belong to the scope of protection of present invention.
Claims (9)
1. a kind of Chinese medicine composition for treating Posterior circulation ischemia dizziness, which is characterized in that the Chinese medicine composition by include with
The raw material of lower parts by weight is prepared：15-25 parts of Rhizoma Gastrodiae, 15-25 parts of uncaria, 8-12 parts of Rhizoma Chuanxiong, 10-15 parts of Radix Salviae Miltiorrhizae, pueraria lobata
10-15 parts, 15-30 parts of Caulis Spatholobi, 5-10 parts of trigone, 1-3 parts of leech, 4-8 parts of earthworm.
2. the Chinese medicine composition for the treatment of Posterior circulation ischemia dizziness according to claim 1, which is characterized in that the Chinese medicine
Composition is prepared by the raw material including following parts by weight：20 parts of Rhizoma Gastrodiae, 20 parts of uncaria, 10 parts of Rhizoma Chuanxiong, 13 parts of Radix Salviae Miltiorrhizae, Pueraria lobota
13 parts of root, 22 parts of Caulis Spatholobi, 8 parts of trigone, 2 parts of leech, 6 parts of earthworm.
3. the Chinese medicine composition for the treatment of Posterior circulation ischemia dizziness according to claim 1, which is characterized in that the Chinese medicine
Composition further includes 7-8 parts of Radix Astragali, 7-8 parts of Rhizoma Atractylodis Macrocephalae.
4. the Chinese medicine composition for the treatment of Posterior circulation ischemia dizziness according to claim 1, which is characterized in that the Chinese medicine
Composition further includes 4-5 parts of radix bupleuri, 4-5 parts of Fructus Aurantii.
5. the Chinese medicine composition for the treatment of Posterior circulation ischemia dizziness according to claim 1, which is characterized in that the Chinese medicine
Composition further includes 1-2 parts of Chinese cassia tree, 7-8 parts of Longstamen Onion Bulb.
6. the Chinese medicine composition for the treatment of Posterior circulation ischemia dizziness according to claim 1, which is characterized in that the Chinese medicine
Composition further includes 4-5 parts of the tuber of pinellia, 4-5 parts of dried orange peel.
7. a kind of preparation side of the Chinese medicine composition for the treatment of Posterior circulation ischemia dizziness as described in any one of claim 1-6
Method, which is characterized in that the preparation method includes the following steps：
Step 1：Weigh each raw material of corresponding parts by weight；
Step 2：Other each raw materials in addition to earthworm are placed in medicine pot, suitable water is added and impregnates 10-30 minutes；
Step 3：Big fire boils 10-25 minutes；Turn small fire, continues tanning 10-25 minutes；
Step 4：Flame-out, filter and remove residue obtains filtrate；
Step 5：The earthworm dried is pulverized, is added in filtrate obtained by step 4, stirs evenly and is recycled up to after treatment
The Chinese medicine composition of ischemia vertigo.
8. the preparation method of the Chinese medicine composition for the treatment of Posterior circulation ischemia dizziness according to claim 7, feature exist
In in step 2, the total weight ratio of the water of addition and each Chinese medicine material is 4:1-10:1.
9. a kind of Chinese medicine composition as described in any one of claim 1-6 is after the treatment in circulation ischemia vertigo medicament
Using.
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