CN104056088A - Traditional Chinese medicinal composition for treating insomnia and application thereof - Google Patents
Traditional Chinese medicinal composition for treating insomnia and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating insomnia. The composition is prepared from the following raw medicinal materials in parts by weight: 27 parts of Huai wheat, 9 parts of liquorice, 9 parts of radix sophorae flavescentis, 6 parts of periostracum cicada, 9 parts of bombyx batryticatus, 9 parts of rhizona gastrodiae, 15 parts of tender uncaria rhynchophylla, 30 parts of kudzu vine root, 12 parts of ligusticum wallichii, 9 parts of soft radix bupleuri, 27 parts of calcined keel, 12 parts of radix curcumae, 9 parts of rhizoma acori graminei, 12 parts of stir-baked fructus gardeniae, 12 parts of scutellaria baicalensis, 12 parts of red peony root, 12 parts of radix paeoniae alba, 27 parts of radix salviae miltiorrhizae, 27 parts of cortex albiziae and 30 parts of tuber fleeceflower stem. The invention also provides an application of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition has the effects of calming the liver and resolving depression, clearing heat, activating blood circulation and calming nerves, has a good curative effect in clinical treatment of liver stagnation type insomnia, and can be used for regulating neurotransmitter and hormone disturbance.
Description
Technical field
The present invention relates to medical technical field, specifically, is Chinese medicine composition and the application thereof about a kind for the treatment of of insomnia patients.
Background technology
Insomnia refers in the situation that possessing well sleep condition, occur difficulty falling asleep, repeatedly easily wake up, early awakening, and weekly more than 3 evenings, continuous more than 1 month insomnia, because time and the quality of sleep can not meet organism physiology needs and occur parafunctional one group of syndrome on daytime.Insomnia is equivalent to the traditional Chinese medical science and " is insomnia ".In recent ten years, along with social development accelerates and intensified competition, crowd insomnia sickness rate rises rapidly.Within 2002, report U.S. adults approximately has 1/3rd to have dyskoimesis, 10～15% show obvious insomnia, psychiatric department association of Chinese Medical Association of China is investigated Beijing, Shanghai, Hangzhou, Guangzhou, Shandong, Nanjing and other places on March 21st, 2002, and result shows that it is 43.5% that slight insomnia adds remarkable insomnia.
Insomnia's doctor trained in Western medicine mainly adopts sedative hypnotic, and this class medicine all has dependency and side effect in various degree, and the disadvantages outweigh the advantages for long-term taking.Conventional have a Benzodiazepines (BDZ), as estazolam, alprazolam, clonazepam etc., all there are tranquilizing soporific and angst resistance effect, but also there are obvious dependency and side effect, can cause central nervous system dysfunction, occur clinically the spirit of many complexity, the symptom of nervous dysfunction simultaneously, particularly Cognitive function damage, as memory ability declines, study, work and social activity hypofunction, the risk of the contingencies such as increase is fallen down, traffic accident.
Summary of the invention
The object of the invention is, for deficiency of the prior art, provides a kind of Chinese medicine composition.
One object more of the present invention is that a kind of purposes of Chinese medicine composition is provided.
For achieving the above object, the technical scheme that the present invention takes is:
A Chinese medicine composition for treatment of insomnia patients, described Chinese medicine composition is to be made up of the crude drug of following weight portion: Huai wheat 26-28 part, Radix Glycyrrhizae 8-10 part, Radix Sophorae Flavescentis 10-11 part, Periostracum Cicadae 5-7 part, Os Draconis (calcined) 26-28 part.
Described Chinese medicine composition is to be made up of the crude drug of following weight portion: Huai wheat 26-28 part, Radix Glycyrrhizae 8-10 part, Radix Sophorae Flavescentis 8-10 part, Periostracum Cicadae 5-7 part, soft Radix Bupleuri 8-10 part, Os Draconis (calcined) 26-28 part, RADIX CURCUMAE 11-13 part, peninjau gardenia 11-13 part, Cortex Albiziae 26-28 part, Caulis Polygoni Multiflori 29-31 part.
Described Chinese medicine composition is to be made up of the crude drug of following weight portion: Huai wheat 26-28 part, Radix Glycyrrhizae 8-10 part, Radix Sophorae Flavescentis 8-10 part, Periostracum Cicadae 5-7 part, RHIZONA GASTRODIAE 8-10 part, tender Ramulus Uncariae Cum Uncis 14-16 part, soft Radix Bupleuri 8-10 part, Os Draconis (calcined) 26-28 part, RADIX CURCUMAE 11-13 part, Rhizoma Acori Graminei 8-10 part, peninjau gardenia 11-13 part, Radix Scutellariae 11-13 part, Radix Paeoniae Alba 11-13 part, Cortex Albiziae 26-28 part, Caulis Polygoni Multiflori 29-31 part.
Described Chinese medicine composition is to be made up of the crude drug of following weight portion: Huai wheat 26-28 part, Radix Glycyrrhizae 8-10 part, Radix Sophorae Flavescentis 8-10 part, Periostracum Cicadae 5-7 part, Bombyx Batryticatus 8-10 part, RHIZONA GASTRODIAE 8-10 part, tender Ramulus Uncariae Cum Uncis 14-16 part, Radix Puerariae 29-31 part, Rhizoma Chuanxiong 11-13 part, soft Radix Bupleuri 8-10 part, Os Draconis (calcined) 26-28 part, RADIX CURCUMAE 11-13 part, Rhizoma Acori Graminei 8-10 part, peninjau gardenia 11-13 part, Radix Scutellariae 11-13 part, Radix Paeoniae Rubra 11-13 part, Radix Paeoniae Alba 11-13 part, Radix Salviae Miltiorrhizae 26-28 part, Cortex Albiziae 26-28 part, Caulis Polygoni Multiflori 29-31 part.
Described Chinese medicine composition is to be made up of the crude drug of following weight portion: 27 parts of Huai wheats, 9 parts, Radix Glycyrrhizae, 9 parts of Radix Sophorae Flavescentiss, 6 parts of Periostracum Cicadaes, 9 parts of Bombyx Batryticatus, 9 parts of RHIZONA GASTRODIAE, 15 parts of tender Ramulus Uncariae Cum Uncis, 30 parts of Radix Puerariaes, 12 parts of Rhizoma Chuanxiongs, 9 parts of soft Radix Bupleuri, 27 parts of Os Draconis (calcined)s, 12 parts of RADIX CURCUMAEs, 9 parts of Rhizoma Acori Graminei, 12 parts of peninjau gardenias, 12 parts of Radix Scutellariaes, 12 parts of Radix Paeoniae Rubra, 12 parts of the Radix Paeoniae Albas, 27 parts of Radix Salviae Miltiorrhizae, 27 parts of Cortex Albiziaes, 30 parts of Caulis Polygoni Multiflori.
For realizing above-mentioned second object, the technical scheme that the present invention takes is:
Chinese medicine composition, the application in preparation insomnia disease medicament compositions.
Described insomnia is stagnation of liver-QI blood stasis blocking type insomnia.
The invention has the advantages that:
Chinese medicine composition of the present invention has suppressing the hyperactive liver resolving depression, the effect that heat clearing and blood circulation promoting is calmed the nerves, and clinical treatment stagnation of liver-QI blood stasis blocking type insomnia has good therapeutic effect, and neurotransmitter and hormone disturbance are had to regulating action.Experiment finds that sweet wheat LONGMU soup can reduce Sleep in Rats and deprive in rear cerebrospinal fluid and serum 5-HT, TSH, NE, CORTISOL content in PGD2 content, serum, traditional Chinese medicine composition for treating insomnia of the present invention, may be that this is a new discovery by regulating neurotransmitter and hormone in cerebrospinal fluid and serum to play a role.Medicine of the present invention reduces toxic and side effects in improving curative effect.The side effect of this poison of drug is little, is suitable for long-term taking, is a kind of medicine for the treatment of of insomnia patients safely and effectively.
Brief description of the drawings
Accompanying drawing 1 is animal experiment technique route.
Detailed description of the invention
Below detailed description of the invention provided by the invention is elaborated.
Embodiment 1
1 data and method
The diagnostic criteria Western medicine diagnose standard of 1.1 diseases is with reference to " practical internal medicine ", " psychiatry ", " internal disease diagnostic criteria ", ICD-10F51.0 insomnia's diagnostic criteria: 1. sleep disorder: comprise difficulty falling asleep, be interrupted and wake up more, dreaminess, seemingly sleep and non-ly sleep, early awakening, can not fall asleep after waking up again, be insomnia even all night.2. above-mentioned sleep disorder at least occurs weekly 3 times, and continues more than 4 weeks.3. there is tired, lassitude, dizzy feeling of fullness in the head, the nervous symptom such as vexed daytime, affect the social activity such as work, study function.
" the Shanghai City traditional Chinese medical science insomnia characteristic diagnosis and treatment scheme " that Standards of Chinese Medical Syndrome Differentiation is formulated with reference to Shanghai Chinese Medicine Hospital sleep disease research.
Stagnation of liver-QI stasis blocking: emotion is unhappy, difficulty is slept at nightfall, and distending pain in the chest and hypochondrium is vexed gloomy, speaking scarcely,taciturn, dim complexion, eye socket darkish complexion, ecchymosis under socket of the eye, body of the tongue is dark violet, and there are petechia, ecchymosis in tongue limit.
Inclusive criteria 1. men and women all can, the age was 18 years old～70 years old (containing 18 years old, 70 years old).2. meet insomnia's diagnosis.3. meet stagnation of liver-QI blood stasis blocking type standard.
Exclusion standard
1. the insomnia that medicine or ethanol cause;
2. the insomnia that other mental sickness causes;
3. pregnancy, suckling or the women that possibility pregnancy can not be adopted an effective measure under study for action.
Insomnia type is divided initial type (difficulty falling asleep according to sleeping problems time of origin in the night, need more than 1 hour just can fall asleep), discontinuous form (sleep in the middle of wake up more than twice, sleep not stable, dreaminess), terminal type (early awakening, after waking up, can not fall asleep again, between the more conventional WA of early awakening ahead of time more than 1 hour), type (can not fall asleep all night), dreaminess type (dreaminess is diverse and confused whole night, tired after waking up), mixed type (having two or more insomnia type) all night.
Therapeutic Method
The present invention: enter 15 grams, 30 grams of Radix Puerariaes, 12 grams of Rhizoma Chuanxiongs, 9 grams of soft Radix Bupleuri, 27 grams of Os Draconis (calcined)s, 12 grams of RADIX CURCUMAEs, 9 grams of Rhizoma Acori Graminei, 12 grams of peninjau gardenias, 12 grams of Radix Scutellariaes, 12 grams of Radix Paeoniae Rubra, 12 grams of the Radix Paeoniae Albas, 27 grams of Radix Salviae Miltiorrhizae, 27 grams of Cortex Albiziaes, 30 grams of Caulis Polygoni Multiflori after 27 grams of Huai wheats, 9 grams, Radix Glycyrrhizae, 9 grams of Radix Sophorae Flavescentiss, 6 grams of Periostracum Cicadaes, 9 grams of Bombyx Batryticatus, 9 grams of RHIZONA GASTRODIAE, tender Ramulus Uncariae Cum Uncis.Every day potion.
Chinese medicine decoction method: Chinese medicine is with cold water soak about 30 minutes, water logging is crossed to powder one finger, and one pastes medicine decocts twice, and first big fire is boiled, boil about 30 minutes with little fire again, leach approximately 200 milliliters of medicine juice, this decocts for head, then adds water and decoct once by upper method, leach approximately 200 milliliters of medicine juice, this is two to decoct, and head decocts, two decoct after mixing, respectively at sooner or later taking after meal 200 milliliters half an hour.
Case load is observed 200 examples, treats 4 weeks.
Observing time in JIUYUE, 2011---in February, 2014
1.8 observation index and evaluation of clinical curative effect method
1.8.1 before observation index treatment, after 4 weeks, evaluate respectively " traditional Chinese medical science insomnia's syndrome differential diagnosis and the perspective evaluation form for the treatment of " and Pittsburgh index scale, Hamilton depressive scale (HAMD) with treatment.
1.8.2 curative effect index: SPIEGEL scale, tcm symptom syndrome scale, Pittsburgh index scale (PSQI), Hamilton depressive scale (HAMD) scoring.
1.8.3 1. SPIEGEL scale scoring of curative effect determinate standard: employing subtracts a point rate method and makes therapeutic evaluation, divides 4 grades: clinical recovery, effective, effective, invalid.Subtract a point rate=(before treating, rear scoring is treated in scoring one)/scoring × 100% before treating.Final curative effect is made statistics with the 4th week testing result data.Clinical recovery: refer to symptom completely or substantially disappear, SPIEGEL scale subtracts point rate >=75%.Effective: refer to the most of disappearance of symptom, SPIEGEL scale subtracts point rate >=50%.Effective: refer to partial symptoms improvement, SPIEGEL scale subtracts point rate >=30%.Invalid: symptom is unchanged or increase the weight of, SPIEGEL scale subtracts a point rate < 30%.
2. tcm symptom syndrome scale scoring: relatively before and after treatment, whether total score has significant difference.
3. Pittsburgh index scale (PSQI): PSQI is for evaluating the sleep quality of tested nearest 1 month, by 18 entries, form 7 factors, each factor is by 0,1,2,3 grades score, and each factor is divided and is accumulated as PSQI total score, total score scope is 0～21, be greater than 7 as dividing value taking PSQI total score, be less than 7 points of persons for ortho sleep, be greater than 7 points of persons can be judged to sleep disorder, score is higher, represents that sleep quality is poorer.Before and after statistics treatment, whether total score changes variant.
4. Hamilton depressive scale (HAMD) scoring: the description according to 17 HAMD orders of severity: 24 points is major depression above, 17 are divided into moderate depression, 7 are divided into slight depression, and 7 points following without depressed, and before and after observation treatment, more whether total score has significant difference.
Statistical analysis adopts SPSS18.0 software to carry out statistical analysis, and enumeration data adopts X
2check analysis, measurement data adopts T inspection to analyze, and ranked data adopt Radit inspection.
Result
The routine stagnation of liver-QI blood stasis blocking type of 2.1 physical data 200 patient, all comes from king outstanding figure old docter of TCM VIP Clinic (No. 274, Zhi Jiang Road) on every Fridays, wherein female's 155 examples, male 45 examples, Shanghai patient 105 examples, nonlocal patient's 95 examples, Patients with Medical Insurance 71 examples, patient's 129 examples at one's own expense, occupation: financial 4 people, engineer 2 people, workman 6 people, civil servant 2 people, management 3 people, housework 13 people, teacher 10 people, businessman 29 people, retirement 56 people, student 4 people, office worker 71 people.Age: 18～20 years old 2 people, 21～30 years old 30 people, 31～40 years old 57 people, 41～50 years old 50 people, 51～60 years old 31 people, 61～70 years old 30 people.Age distribution is in table 1.
The routine insomnia's age distribution of table 1 200
In the course of disease 200 examples, the course of disease is January～1 year (containing 1 year) 59 people, 1 year～5 years (containing 5 years) 55 people, 5 years～10 years (containing 10 years) 68 people, 10 years～20 years (containing 20 years) 13 people, 20 years above 5 people.The course of disease distributes in table 2.
The routine insomnia's course of disease of table 2 200 distributes
In risk factor 200 examples, do not expose 24 examples that have of reason, account for 12%, all the other 176 examples have different risk factors, be respectively psychologic factors and bring out 164 examples (82%), wherein unhappy 96 examples of feelings will (48%), psychentonia 63 examples (31.5%), scaring causes 5 examples (2.50%) of being insomnia; Environmental factors is brought out 10 examples (5%), and wherein live irregular (sleep evening) causes 7 examples (3.50%) of being insomnia, environmental disturbances (residence change, noise etc.) 3 examples (1.50%); Disease factor brings out 16 examples (8%) (disease has rubella, tinnitus, hepatitis, lupus erythematosus, hyperthyroidism, cerebral infarction, diabetes, injury of head, gastritis, cataract etc.), medicine factor is brought out 1 example (0.50%), other various risk factors amount to 34 examples (17%), and various risk factors are in table 3.
Table 3 risk factor
(note: the patient's risk factor having in 200 routine patients has more than one, as both in love will was unhappy, spiritedness overwork again, has 249 examples therefore statistics risk factor adds up to.)
Insomnia type is taking mixed type as main, and 132 examples, account for 66.00%.Secondly be terminal type, type all night.In table 4.
Table 4 type of having a sleepless night
Relating to his the dirty internal organs that relate generally to is kidney, stomach, accounts for respectively 55%, 12.50%.In table 5.
Table 5 relates to that he is dirty
Merge disease and be associated with disease 64 examples (being mainly hypertension, hyperlipidemia, coronary heart disease, chronic gastritis and gynaecopathia etc.), account for 32%, do not expose and have other diseases 136 examples, account for 68%.
Clinical global impression moderate 130 examples, account for 65%, and severe 70 examples, account for 35%.
Therapeutic outcome
2.2.1SPIEGEL scale subtracts point rate efficacy determination in table 6
Table 6 SPIEGEL scale efficacy determination
According to the scoring of SPIEGEL scale, employing subtracts a point rate method and makes therapeutic evaluation, recovery from illness 24 examples, effective 64 examples, effective 64 examples, invalid 48 examples, total effective rate 76%, total obvious effective rate 44%.
2.2.2 treatment front and back SPIEGEL scale total score is relatively in table 7
SPIEGEL scale total score comparison before and after table 7 treatment
Treatment after SPIEGEL scale total score reduce, with treatment before relatively have significant difference, P=0.000.
Before and after treatment, tcm symptom syndrome scale is marked relatively in table 8
Before and after table 8 treatment, the scoring of tcm symptom syndrome scale relatively
After treatment, tcm symptom syndrome scale scoring reduces, and relatively has significant difference, P=0.000 before treatment.
Before and after treatment, Pittsburgh index scale (PSQI) is marked relatively in table 9
Before and after table 9 treatment, Pittsburgh index scale (PSQI) scoring relatively
Treatment after Pittsburgh index scale reduce, with treatment before relatively have significant difference, P=0.000.
Before and after treatment, Hamilton depressive scale (HAMD) is marked relatively in table 10
Before and after table 10 treatment, Hamilton depressive scale (HAMD) scoring relatively
After treatment, Hamilton depressive scale scoring reduces, and relatively has significant difference, P=0.000 before treatment.
Embodiment 2
The impact of Chinese medicine composition of the present invention on neurotransmitter, hormone in sleep-deprived rat serum
1. data and method
1.1 laboratory animals sources Shanghai western pul-Bi Kai laboratory animal company limiteies provide SD rat, and SPF level is male, 4 weeks age rat, body weight 180～220g, the quality certification is numbered: 2008001635587.
Grouping and sample size are established Normal group (A group), sleep deprivation group (B group), sweet wheat LONGMU soup sleep deprivation group (C group), sweet wheat LONGMU soup group (D group).Rat adaptability is raised after 3d, with random point 4 groups of random number generators in EXCEL, 11 every group.
Medication and observed content rat adaptability are fed after 3d, divide at random 4 groups, and A group and B group, give 0.9% sodium chloride injection; C group and D group, give sweet wheat LONGMU soup, is 10mlkg
-1(for 4.2 times of 70kg people's use dosage).4 groups of rat 9 gastric infusions in the morning equal every day 1 time, continuous 10 days.In the time of the 7th day, B group and C group are carried out sleep deprivation (during sleep deprivation also every day gavage once), after 72 hours, finish sleep deprivation; A group, D group are not carried out sleep deprivation.
Adopting the multi-platform legal system of improvement to carry out Sleep in Rats for sleep deprivation model deprives.Sleep deprivation case size is 30cm × 30cm × 150cm, and it is 6cm that diameter is placed by central authorities, the platform of high 8cm, totally 11, interval 15cm between platform.Deprive in case and be marked with water, the water surface is lower than the about 1cm of platform, and water temperature remains on (20 ± 2) DEG C.Rat is platform is enterprising while entering to sleep, wakes up with a start, causes sleep deprivation because skeletal muscle lax fallen in water rat.Contrast is large platform, diameter 12.0cm, and rat can enter sleep on platform.During sleep deprivation, continue daylight lamp photograph, change water in sleep deprivation case every day to ensure sanitation and hygiene.
Medicine is got the present invention 6 and is pasted (after 27 grams of Huai wheats, 9 grams, Radix Glycyrrhizae, 9 grams of Radix Sophorae Flavescentiss, 6 grams of Periostracum Cicadaes, 9 grams of 9 grams of RHIZONA GASTRODIAE of Bombyx Batryticatus, tender Ramulus Uncariae Cum Uncis, entering 15 grams, 30 grams of Radix Puerariaes, 12 grams of Rhizoma Chuanxiongs, 9 grams of soft Radix Bupleuri, 27 grams of Os Draconis (calcined)s, 12 grams of RADIX CURCUMAEs, 9 grams of Rhizoma Acori Graminei, 12 grams of peninjau gardenias, 12 grams of Radix Scutellariaes, 12 grams of Radix Paeoniae Rubra, 12 grams of the Radix Paeoniae Albas, 27 grams of Radix Salviae Miltiorrhizae, 27 grams of Cortex Albiziaes, 30 grams of Caulis Polygoni Multiflori).All medical material comes from Shanghai Chinese Medicine Hospital Chinese medicine pharmacy, adds for the first time 8 times of water, soaks 15min, and big fire decocts to boiling, changes slow fire boiling 15min into, pours out medical filtration; Add for the second time 6 times of water gagings, decocting method, with for the first time, is poured out filtrate filtration again, and secondary filtrate merges, and is concentrated into 990 milliliters (being equivalent to 1.8g crude drug/ml), and after subpackage sterilizing, 4 degrees Celsius save backup.
PGD in observation index cerebrospinal fluid
2, PGD in peripheral blood
2, 5-HT, TSH, NE, CORTISOL content.
Collection of specimens and processing
1.6.1 cerebrospinal fluid of rats collection and measure and scratch spinal dura mater under direct-view and extract cerebrospinal fluid method: at corresponding observing time of node, with 10% chloral hydrate (300mgkg
-1, lumbar injection) and anesthetized animal.Utilize rat brain stereotaxic instrument ear bar, the fixing rat head of front tooth bar, hair is shaved by headrest portion, cuts a stringer otch (about 2cm) along posterior midline, blunt separation napex dorsal part muscle.Scrape off and be attached to supraoccipital muscle and avoid hemorrhage with the operation knife back, expose after the pillow fascia of extensive region, use distilled water flushing wound surface, after aseptic cotton balls is cleaned, longitudinally scratch spinal dura mater 13cm with scalpel, visible cerebrospinal fluid flows out, and 1ml syringe is placed in to cut place and extracts cerebrospinal fluid 100 μ l.Sample is immediately placed in the freezing preservation of liquid nitrogen.Use enzyme to exempt from method and measure PGD
2content.
Blood sample collection has extracted after cerebrospinal fluid, abdominal vein is got blood 4ml rapidly, blood leaves standstill 0.5h in ice bath test tube, 4 DEG C, the centrifugal 10min of 3000rPmin, separation of serum, be kept in the refrigerator of-80 DEG C, with PGD2 to be measured and, the content of 5-HT, TSH, NE, CORTISOL, concrete operations are carried out (the import subpackage ELISA of RD company of U.S. test kit, lot number: 201312 according to test kit step.)
1.7 key instrument equipment Thermo Fresco-17 centrifuges (U.S.), Bio-Rad680 microplate reader (U.S.), MMM-group constant incubator (Germany), eppendorf pipettor (Germany), experiment consumptive material suction nozzle eppendorf, EP manage Axygen.
Statistical data analysis is carried out statistical analysis with SPSS18.0, all datas with
represent.
Animal experiment technique route is shown in Fig. 1.
2 experimental results
2.1 Normal-weight matched groups have a rat serum sample hemolysis, reject, when having a gavage, sweet wheat LONGMU group chokes into trachea death, reject finally 42, total sample, each group body weight zero difference in the time that first day divides into groups, each group body weight zero difference before the 7th day sleep deprivation, within the tenth day, (after sleep deprivation, draw materials before) body weight B group, C group obviously alleviate, and B group has significant difference with A group, D group, and C group has significant difference with A group, D group.In table 11.
Each period body weight of table 11
Note: A group: Normal group B group: sleep deprivation group C group: sweet wheat LONGMU soup sleep deprivation group
D group: sweet wheat LONGMU soup group
▲b group compares with A group, and P=0.000, has significant difference;
◆b group compares with D group, and P=0.000, has significant difference;
★c group compares with A group, and P=0.000, has significant difference;
group compares with D group, and P=0.000, has significant difference.
In cerebrospinal fluid, in PGD2 content comparison C group, there is an example to extract cerebrospinal fluid failure, reject statistics, PGD in B group cerebrospinal fluid
2content, higher than A, C, D group, has significant difference, PGD in C group cerebrospinal fluid
2content, lower than B group, has significant difference, with A group, relatively zero difference of D group.In table 12.
PGD in table 12 cerebrospinal fluid
2content
Note: A group: Normal group B group: sleep deprivation group C group: sweet wheat LONGMU soup sleep deprivation group
D group: sweet wheat LONGMU soup group
▲b group compares with A group, and P=0.000, has significant difference;
group compares with B group, and P=0.001, has significant difference.
In peripheral blood serum, PGD2 content compares PGD in B group peripheral blood serum
2content, higher than A, C, D group, has significant difference, PGD in C group peripheral blood serum
2content, lower than B group, has significant difference, with A group, relatively zero difference of D group, in table 13.
PGD in table 13 peripheral blood serum
2content comparison
Note: A group: Normal group B group: sleep deprivation group C group: sweet wheat LONGMU soup sleep deprivation group
D group: sweet wheat LONGMU soup group
▲b group compares with A group, and P=0.000, has significant difference;
group compares with B group, and P=0.000, has significant difference.
In peripheral blood serum, 5-HT content compares 5-HT content in B group peripheral blood serum, higher than A, C, D group, has significant difference, and in C group peripheral blood serum, 5-HT content, lower than B group, has significant difference, with relatively zero difference of A group, in table 14.
5-HT content comparison in table 14 peripheral blood serum
Note: A group: Normal group B group: sleep deprivation group C group: sweet wheat LONGMU soup sleep deprivation group
D group: sweet wheat LONGMU soup group
▲b group compares with A group, and P=0.000, has significant difference;
group compares with B group, and P=0.000, has significant difference.
In peripheral blood serum, TSH content compares TSH content in B group peripheral blood serum, higher than A, C, D group, has significant difference, and in C group peripheral blood serum, TSH content, lower than B group, has significant difference, with A group, relatively zero difference of D group, in table 15.
TSH content comparison in table 15 peripheral blood serum
Note: A group: Normal group B group: sleep deprivation group C group: sweet wheat LONGMU soup sleep deprivation group
D group: sweet wheat LONGMU soup group
▲b group compares with A group, and P=0.001, has significant difference;
group compares with B group, and P=0.001, has significant difference.
NE content comparison in peripheral blood serum
In B group peripheral blood serum, NE content, higher than A, C, D group, has significant difference, and in C group peripheral blood serum, NE content, lower than B group, has significant difference, with A group, relatively zero difference of D group, in table 16.
NE content comparison in table 16 peripheral blood serum
Note: A group: Normal group B group: sleep deprivation group C group: sweet wheat LONGMU soup sleep deprivation group
D group: sweet wheat LONGMU soup group
▲b group compares with A group, and P=0.020, has significant difference;
group compares with B group, and P=0.003, has significant difference.
In peripheral blood serum CORTISOL content relatively in B group peripheral blood serum CORTISOL content higher than A, C, D group, but with A group relatively, P=0.277, zero difference, in C group peripheral blood serum CORTISOL content lower than B group, but P=0.060, zero difference, with A group, relatively zero difference of D group, in table 17.
CORTISOL content comparison in table 17 peripheral blood serum
Note: A group: Normal group B group: sleep deprivation group C group: sweet wheat LONGMU soup sleep deprivation group
D group: sweet wheat LONGMU soup group
Known by above-mentioned data: Sleep in Rats is deprived PGD in rear cerebrospinal fluid and Peripheral Blood
2, 5-HT, TSH, NE, CORTISOL and Normal group have significant difference in serum, take PGD in sleep-deprived rat cerebrospinal fluid of the present invention and serum
2, 5-HT, TSH, NE, CORTISOL level and Normal group zero difference in serum.
Embodiment 3
1 data and method
The diagnostic criteria Western medicine diagnose standard of 1.1 diseases is with embodiment 1
1.2 Standards of Chinese Medical Syndrome Differentiations are with embodiment 1
1.3 inclusive criterias are with embodiment 1
1.4 exclusion standards are with embodiment 1
1.5 insomnia types are with embodiment 1
1.6 Therapeutic Method
Traditional chinese medicine medicament group
Group (one): 26 grams of Huai wheats, 10 grams, Radix Glycyrrhizae, 11 grams of Radix Sophorae Flavescentiss, 5 grams of Periostracum Cicadaes, 28 grams of Os Draconis (calcined)s
Group (two): 28 grams of Huai wheats, 8 grams, Radix Glycyrrhizae, 10 grams of Radix Sophorae Flavescentiss, 7 grams of Periostracum Cicadaes, 26 grams of Os Draconis (calcined)s
Group (three): 27 grams of Huai wheats, 9 grams, Radix Glycyrrhizae, 9 grams of Radix Sophorae Flavescentiss, 6 grams of Periostracum Cicadaes, 27 grams of Os Draconis (calcined)s
Group (four): 26 grams of Huai wheats, 10 grams, Radix Glycyrrhizae, 11 grams of Radix Sophorae Flavescentiss, 5 grams of Periostracum Cicadaes, 28 grams of Os Draconis (calcined)s, 8 grams of soft Radix Bupleuri, 13 grams of RADIX CURCUMAEs, 11 grams of peninjau gardenias, 26 grams of Cortex Albiziaes, 29 grams of Caulis Polygoni Multiflori.
Group (five): 28 grams of Huai wheats, 8 grams, Radix Glycyrrhizae, 10 grams of Radix Sophorae Flavescentiss, 7 grams of Periostracum Cicadaes, 26 grams of Os Draconis (calcined)s, 10 grams of soft Radix Bupleuri, 11 grams of RADIX CURCUMAEs, 13 grams of peninjau gardenias, 28 grams of Cortex Albiziaes, 31 grams of Caulis Polygoni Multiflori.
Group (six): 27 grams of Huai wheats, 9 grams, Radix Glycyrrhizae, 9 grams of Radix Sophorae Flavescentiss, 6 grams of Periostracum Cicadaes, 9 grams of soft Radix Bupleuri, 27 grams of Os Draconis (calcined)s, 12 grams of RADIX CURCUMAEs, 12 grams of peninjau gardenias, 27 grams of Cortex Albiziaes, 30 grams of Caulis Polygoni Multiflori.
Group (seven): enter 14 grams, 8 grams of Rhizoma Acori Graminei, 11 grams of Radix Scutellariaes, 13 grams of the Radix Paeoniae Albas after 26 grams of Huai wheats, 10 grams, Radix Glycyrrhizae, 11 grams of Radix Sophorae Flavescentiss, 5 grams of Periostracum Cicadaes, 28 grams of Os Draconis (calcined)s, 8 grams of soft Radix Bupleuri, 13 grams of RADIX CURCUMAEs, 11 grams of peninjau gardenias, 26 grams of Cortex Albiziaes, 29 grams of Caulis Polygoni Multiflori, 8 grams of RHIZONA GASTRODIAE, tender Ramulus Uncariae Cum Uncis.
Group (eight): enter 16 grams, 10 grams of Rhizoma Acori Graminei, 13 grams of Radix Scutellariaes, 11 grams of the Radix Paeoniae Albas after 28 grams of Huai wheats, 8 grams, Radix Glycyrrhizae, 10 grams of Radix Sophorae Flavescentiss, 7 grams of Periostracum Cicadaes, 26 grams of Os Draconis (calcined)s, 10 grams of soft Radix Bupleuri, 11 grams of RADIX CURCUMAEs, 13 grams of peninjau gardenias, 28 grams of Cortex Albiziaes, 31 grams of Caulis Polygoni Multiflori, 8 grams of RHIZONA GASTRODIAE, tender Ramulus Uncariae Cum Uncis.
Group (nine):
After 27 grams of Huai wheats, 9 grams, Radix Glycyrrhizae, 9 grams of Radix Sophorae Flavescentiss, 6 grams of Periostracum Cicadaes, 10 grams of RHIZONA GASTRODIAE, tender Ramulus Uncariae Cum Uncis, enter 15 grams, 9 grams of soft Radix Bupleuri, 27 grams of Os Draconis (calcined)s, 12 grams of RADIX CURCUMAEs, 9 grams of Rhizoma Acori Graminei, 12 grams of peninjau gardenias, 12 grams of Radix Scutellariaes, 12 grams of the Radix Paeoniae Albas, 27 grams of Cortex Albiziaes, 27 grams of Caulis Polygoni Multiflori
Group (ten):
After 26 grams of Huai wheats, 8 grams, Radix Glycyrrhizae, 10 grams of Radix Sophorae Flavescentiss, 5 grams of Periostracum Cicadaes, 8 grams of Bombyx Batryticatus, 10 grams of RHIZONA GASTRODIAE, tender Ramulus Uncariae Cum Uncis, enter 16 grams, 29 grams of Radix Puerariaes, 13 grams of Rhizoma Chuanxiongs, 10 grams of soft Radix Bupleuri, 26 grams of Os Draconis (calcined)s, 11 grams of RADIX CURCUMAEs, 8 grams of Rhizoma Acori Graminei, 11 grams of peninjau gardenias, 11 grams of Radix Scutellariaes, 11 grams of Radix Paeoniae Rubra, 13 grams of the Radix Paeoniae Albas, 26 grams of Radix Salviae Miltiorrhizae, 26 grams of Cortex Albiziaes, 29 grams of Caulis Polygoni Multiflori
Group (11):
After 26 grams of Huai wheats, 10 grams, Radix Glycyrrhizae, 8 grams of Radix Sophorae Flavescentiss, 7 grams of Periostracum Cicadaes, 10 grams of Bombyx Batryticatus, 8 grams of RHIZONA GASTRODIAE, tender Ramulus Uncariae Cum Uncis, enter 14 grams, 31 grams of Radix Puerariaes, 11 grams of Rhizoma Chuanxiongs, 8 grams of soft Radix Bupleuri, 28 grams of Os Draconis (calcined)s, 13 grams of RADIX CURCUMAEs, 10 grams of Rhizoma Acori Graminei, 13 grams of peninjau gardenias, 13 grams of Radix Scutellariaes, 13 grams of Radix Paeoniae Rubra, 11 grams of the Radix Paeoniae Albas, 28 grams of Radix Salviae Miltiorrhizae, 28 grams of Cortex Albiziaes, 31 grams of Caulis Polygoni Multiflori
Chinese medicine decoction method: with embodiment 1
1.7 case loads are observed 1100 examples, and every group of 100 examples are treated 4 weeks.
In January, 2009 observing time---in February, 2014
1.8 observation index and evaluation of clinical curative effect method
SPIEGEL scale is with embodiment 1
1.9 statistical analysiss are with embodiment 1
2. therapeutic outcome
SPIEGEL scale subtracts point rate efficacy determination in table 18
Table 18 SPIEGEL scale efficacy determination
Traditional Chinese medicine composition for treating stagnation of liver-QI blood stasis blocking type insomnia of the present invention truly has good therapeutic effect, can further be applicable clinical.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the inventive method; can also make some improvement and supplement, these improvement and the supplementary protection scope of the present invention that also should be considered as.
Claims (7)
1. a Chinese medicine composition for treatment of insomnia patients, is characterized in that, described Chinese medicine composition is to be made up of the crude drug of following weight portion: Huai wheat 26-28 part, Radix Glycyrrhizae 8-10 part, Radix Sophorae Flavescentis 10-11 part, Periostracum Cicadae 5-7 part, Os Draconis (calcined) 26-28 part.
2. the Chinese medicine composition of a treatment of insomnia patients, it is characterized in that, described Chinese medicine composition is to be made up of the crude drug of following weight portion: Huai wheat 26-28 part, Radix Glycyrrhizae 8-10 part, Radix Sophorae Flavescentis 8-10 part, Periostracum Cicadae 5-7 part, soft Radix Bupleuri 8-10 part, Os Draconis (calcined) 26-28 part, RADIX CURCUMAE 11-13 part, peninjau gardenia 11-13 part, Cortex Albiziae 26-28 part, Caulis Polygoni Multiflori 29-31 part.
3. the Chinese medicine composition of a treatment of insomnia patients, it is characterized in that, described Chinese medicine composition is to be made up of the crude drug of following weight portion: Huai wheat 26-28 part, Radix Glycyrrhizae 8-10 part, Radix Sophorae Flavescentis 8-10 part, Periostracum Cicadae 5-7 part, RHIZONA GASTRODIAE 8-10 part, tender Ramulus Uncariae Cum Uncis 14-16 part, soft Radix Bupleuri 8-10 part, Os Draconis (calcined) 26-28 part, RADIX CURCUMAE 11-13 part, Rhizoma Acori Graminei 8-10 part, peninjau gardenia 11-13 part, Radix Scutellariae 11-13 part, Radix Paeoniae Alba 11-13 part, Cortex Albiziae 26-28 part, Caulis Polygoni Multiflori 29-31 part.
4. the Chinese medicine composition of a treatment of insomnia patients, it is characterized in that, described Chinese medicine composition is to be made up of the crude drug of following weight portion: Huai wheat 26-28 part, Radix Glycyrrhizae 8-10 part, Radix Sophorae Flavescentis 8-10 part, Periostracum Cicadae 5-7 part, Bombyx Batryticatus 8-10 part, RHIZONA GASTRODIAE 8-10 part, tender Ramulus Uncariae Cum Uncis 14-16 part, Radix Puerariae 29-31 part, Rhizoma Chuanxiong 11-13 part, soft Radix Bupleuri 8-10 part, Os Draconis (calcined) 26-28 part, RADIX CURCUMAE 11-13 part, Rhizoma Acori Graminei 8-10 part, peninjau gardenia 11-13 part, Radix Scutellariae 11-13 part, Radix Paeoniae Rubra 11-13 part, Radix Paeoniae Alba 11-13 part, Radix Salviae Miltiorrhizae 26-28 part, Cortex Albiziae 26-28 part, Caulis Polygoni Multiflori 29-31 part.
5. Chinese medicine composition according to claim 4, it is characterized in that, described Chinese medicine composition is to be made up of the crude drug of following weight portion: 27 parts of Huai wheats, 9 parts, Radix Glycyrrhizae, 9 parts of Radix Sophorae Flavescentiss, 6 parts of Periostracum Cicadaes, 9 parts of Bombyx Batryticatus, 9 parts of RHIZONA GASTRODIAE, 15 parts of tender Ramulus Uncariae Cum Uncis, 30 parts of Radix Puerariaes, 12 parts of Rhizoma Chuanxiongs, 9 parts of soft Radix Bupleuri, 27 parts of Os Draconis (calcined)s, 12 parts of RADIX CURCUMAEs, 9 parts of Rhizoma Acori Graminei, 12 parts of peninjau gardenias, 12 parts of Radix Scutellariaes, 12 parts of Radix Paeoniae Rubra, 12 parts of the Radix Paeoniae Albas, 27 parts of Radix Salviae Miltiorrhizae, 27 parts of Cortex Albiziaes, 30 parts of Caulis Polygoni Multiflori.
6. according to the arbitrary described Chinese medicine composition of claim 1-5, in the application of preparing in insomnia's disease medicament compositions.
7. application according to claim 6, described insomnia is stagnation of liver-QI blood stasis blocking type insomnia.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106698A (en) * | 2015-09-08 | 2015-12-02 | 吴持跃 | Traditional Chinese medicine aqueous solution for treating insomnia and preparation method of traditional Chinese medicine aqueous solution |
| CN105106699A (en) * | 2015-09-08 | 2015-12-02 | 吴持跃 | Herbal tea for treating insomnia and preparation method of herbal tea |
| CN105233175A (en) * | 2015-11-12 | 2016-01-13 | 上海市闸北区中医医院 | Acupoint application for treating liver depression and blood stasis resistance type insomnia |
| CN105596975A (en) * | 2015-11-12 | 2016-05-25 | 上海市闸北区中医医院 | Traditional Chinese medicine composition used for treating insomnia |
| CN105878866A (en) * | 2015-01-23 | 2016-08-24 | 耿花娥 | Traditional Chinese medicinal composition for treating insomnia |
| CN115779031A (en) * | 2022-11-16 | 2023-03-14 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating insomnia |
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2014
- 2014-05-30 CN CN201410236956.1A patent/CN104056088A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 胡国华，朱凌云主编: "《冬令调补择膏方——上海市中医医院名家膏方精粹》", 31 October 2008, 中国中医药出版社 * |
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| CN105878866A (en) * | 2015-01-23 | 2016-08-24 | 耿花娥 | Traditional Chinese medicinal composition for treating insomnia |
| CN105106698A (en) * | 2015-09-08 | 2015-12-02 | 吴持跃 | Traditional Chinese medicine aqueous solution for treating insomnia and preparation method of traditional Chinese medicine aqueous solution |
| CN105106699A (en) * | 2015-09-08 | 2015-12-02 | 吴持跃 | Herbal tea for treating insomnia and preparation method of herbal tea |
| CN105233175A (en) * | 2015-11-12 | 2016-01-13 | 上海市闸北区中医医院 | Acupoint application for treating liver depression and blood stasis resistance type insomnia |
| CN105596975A (en) * | 2015-11-12 | 2016-05-25 | 上海市闸北区中医医院 | Traditional Chinese medicine composition used for treating insomnia |
| CN105233175B (en) * | 2015-11-12 | 2018-08-24 | 上海市闸北区中医医院 | A kind of point application for treating the insomnia of liver depression blood stasis blocking type |
| CN105596975B (en) * | 2015-11-12 | 2018-10-16 | 上海市闸北区中医医院 | A kind of Chinese medicine composition for treating insomnia |
| CN116139236A (en) * | 2022-11-04 | 2023-05-23 | 上海市静安区中医医院 | Traditional Chinese medicine composition for treating liver depression type insomnia and application thereof |
| CN116139236B (en) * | 2022-11-04 | 2024-03-22 | 上海市静安区中医医院 | Traditional Chinese medicine composition for treating liver depression type insomnia and application thereof |
| CN115779031A (en) * | 2022-11-16 | 2023-03-14 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating insomnia |
| CN115779031B (en) * | 2022-11-16 | 2023-09-26 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating insomnia |
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