CN103961424A - Traditional Chinese medicine formula for treating cervical spondylosis and preparation method of traditional Chinese medicine capsule preparation - Google Patents
Traditional Chinese medicine formula for treating cervical spondylosis and preparation method of traditional Chinese medicine capsule preparation Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine capsule preparation for treating cervical spondylosis and a preparation method of the traditional Chinese medicine capsule preparation. The traditional Chinese medicine capsule preparation is used for solving the problem that a conventional Chinese patent medicine for treating cervical spondylosis has a poor treatment effect. According to the technical scheme, the preparation method comprises the following steps: soaking raw materials which are radix puerariae, ligusticum wallichii, radix astragali, Chinese angelica, radix paeoniae alba, radix clematidis, eucommia bark, caulis spatholobi, salvia miltiorrhiza, cassia twig, safflower and licorice according to proportions by mass, carrying out heating reflux, settling, filtering, concentrating to obtain a liquid extract, drying, grinding into powder, proportionally adding a dispersing agent and other auxiliary materials, and filling, thus obtaining capsules. The traditional Chinese medicine capsule preparation has the functions of activating blood, dissolving stasis, diminishing inflammation, stopping pain, dispelling wind, eliminating dampness and benefiting liver and kidney. The clinical curative effect observation shows that the traditional Chinese medicine capsule preparation has a good curative effect on various cervical spondylosis, quickly takes effect and can achieve the purpose of treating both symptoms and root causes, and the cervical spondylosis is completely healed and does not relapse. The clinical effective rate and curative rate of the traditional Chinese medicine capsule preparation are higher than those of conventional like products.
Description
Technical field
The present invention relates to Chinese medicine and preparing technical field thereof, be specially a kind of preparation method of Chinese medicine formula and capsule preparations thereof for the treatment of cervical spondylosis.
Background technology
Cervical spondylosis (Ccrvical Spondylosis) claim again cervical vertebra syndrome, it is international frequently-occurring disease, it is the commonly encountered diseases of harm middle-aged and elderly people health, due to the increase of time to bend over one's desk working and kind, popularizing of computer, increasing in a large number and high pillow, the factors such as soft bed of sleeping of private car, and become industry staff's such as being engaged in for a long time electronics, science and technology, culture and education occupation disease.Press the conservative reckoning of existing population, have at least 5,000 ten thousand to 100,000,000 people being subject to the torment of cervical spondylosis.Not only bring great pain to patient, and bring white elephant to family and society.Therefore, the clinical research for the treatment of of cervical spondylopathy has important society and economic implications.Before this, for the treatment of cervical spondylosis, due to operation more complicated, have a big risk, and in art and post-operative complication still difficulty avoid completely.Therefore except a few symptoms has a strong impact on normal work and life, must adopt outside operative treatment, in principle taking non-operative treatment as main.Because Western medicine is mainly playing anti-inflammatory analgetic aspect the treatment of primary disease, expand the effect of blood vessel, therefore curative effect usually can not be satisfactory, and easily repeatedly, side effect is larger.Therefore, using treatment by Chinese herbs cervical spondylosis is effective and the most conventional method, on treatment primary disease, has great advantage.Modern Chinese medicine Chinese medicine has been obtained gratifying achievements to the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of cervical spondylosis on the basis of inheriting forefathers.The Chinese medicine formula preparation application of existing many treatment cervical spondylosiss in recent years patent of invention, wherein just 20 remainders nearly of oral Chinese medicine preparation, the treatment cervical spondylosis Chinese medicine preparation (patent No. 201010503733.9) of for example refined flat invention of Liu; Chinese medicinal tablet and the capsule preparations (patent No. 201110084433.6) of Li Qiurong invention; The Chinese medicine preparation (patent No. 200510119090.7) of ten thousand precious full inventions; The middle medicine composite preparation (patent No. 201210039614.1) of letter good fortune river invention; Open the Chinese medicinal capsule preparation (patent No. 20,101 05,793 09.2) of people's invention etc.Above-mentioned formula is different, and curative effect also has notable difference, and at present the Chinese patent medicine specific aim of the treatment cervical spondylosis of listing is not strong yet, and curative effect is not very good yet, and therefore people expect to develop one and treat the more effective Chinese medicine preparation of cervical spondylosis.But Chinese medicine decoction treatment cervical spondylosis clinical efficacy is definite, but it is longer to take the course for the treatment of, uses comparatively trouble.
Summary of the invention
The present invention, in order to solve the undesirable problem for the treatment of by Chinese herbs effect of existing treatment cervical spondylosis, provides a kind of preparation method of Chinese medicine formula and capsule preparations thereof for the treatment of cervical spondylosis.
The present invention adopts following technical scheme to realize:
Treat a Chinese medicine formula for cervical spondylosis, formed by following component and mass fraction proportioning: 15～30 parts of Radix Puerariaes, 20～30 parts of Rhizoma Chuanxiongs, 15～25 parts of the Radixs Astragali, 15～25 parts of Radix Angelicae Sinensis, 12～25 parts of the Radix Paeoniae Albas, 15～30 parts of Radix Clematidis, 12～25 parts of the Cortexs Eucommiae, 20～30 parts of Caulis Spatholobis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～25 parts of Ramulus Cinnamomi, 10～20 parts, Flos Carthami, 10～20 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis, comprises the steps:
(1), take each component raw material medicine by formula;
(2), above-mentioned raw materials medicine is broken into 20～40 object coarse powder,, by 50～70% soak with ethanol of 4～8 times of amounts 18～24 hours, reflux 2～4 hours, collects one time extracting solution;
(3) add, again 50～70% alcohol heating reflux 2～3 hours of 2～4 times of amounts, collect secondary raffinate;
(4), filter after merging above-mentioned secondary raffinate, add 0.1～0.5% sedimentation agent in filtrate, after stirring, filter, concentrating under reduced pressure becomes fluid extract, dries and obtains dry extract afterwards at 50～60 DEG C;
(5) by adding medicine dispersant and adjuvant after dry extract pulverizing, fill and be prepared into capsule.
Above-mentioned preparation method and method comparison traditional and document, removed numerous and diverse post-processing step of precipitate with ethanol and water precipitating in the past, and production technology is simplified more, and production cost obviously reduces.Therefore the method have easy and simple to handle, equipment investment is little, the feature of economic benefit height.
The present invention is under the not enough reality existing at the Chinese medicine preparation of drawing more existing treatment cervical spondylosiss, develops a kind of good effect, and instant effect, is difficult for recurrence, can reach treating both the principal and secondary aspects of a disease, and Chinese medicinal capsule preparation easy to carry and use.This Chinese patent medicine preparation has the effect of blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, expelling wind and removing dampness, liver and kidney tonifying.Clinical observation on the therapeutic effect shows its determined curative effect to all kinds of cervical spondylosis.
Radix Puerariae: be the tuber of liana Herba Gelsemii Elegantis; Cool in nature, acrid in the mouth, sweet, returns spleen, stomach warp.Energy expelling pathogenic factors from muscles for reducing heat, treating measles, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.If exterior syndrome due to wind-cold, disease sees that aversion to cold is lossless, stiff nape and back, often joins Herba Ephedrae, Ramulus Cinnamomi etc., as GEGEN TANG." herbal classic ": " main quenching one's thirst, high fever of the body, vomiting, all numbness, plays cloudy gas, separates all poison." " not Lu ": " and the excessive cold invading middle-JIAO(the spleen and stomach) wind headache of curing the wound, expelling pathogenic factors from muscles is delivered, perspires, loosing the interspaces of skin and muscles.”
Radix Angelicae Sinensis: warm in nature, acrid in the mouth, sweet, return liver, the heart, spleen channel.Can enrich blood invigorate blood circulation, menstruction regulating and pain relieving, intestine moistening.Have cold coagulation and traumatic injury concurrently, the pain of wind-damp numbness for blood stagnancy due to deficiency of QI.Dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons.Jing-Yue Complete Works: " Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood; Its gas is light and pungent, therefore again can promoting the circulation of blood: invigorating middle warmer has, in row, has benefit, is really the gas medicine in blood, and also the panacea in blood also ".
The Radix Astragali: slightly warm in nature, sweet in the mouth, return spleen, lung meridian.There is tonifying Qi and lifting yang, benefit and defend effect of consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting.To the not all right arthralgia pain of blood stagnancy due to deficiency of QI, numbness or hemiplegia, energy QI invigorating row is stagnant." pearl sac ": " the sweet Wen Chunyang of the Radix Astragali, it is with having five: mend all empty deficiencies, one also; Benefit vigour, two also: strong taste, three also; Go flesh heat, four also; Evacuation of pus pain relieving, the hemopoietic of invigorating blood circulation, expelling the toxic substance from the body with tonic carbuncle of yin nature, is persons particularly liable to develop skin infection's panacea ".
Rhizoma Chuanxiong (formal name used at school:
ligusticum chuanxiong): warm in nature, acrid in the mouth, return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is logical, can invigorate blood circulation and can circulation of qi promoting, and be gas medicine in blood, for the pain disease of stagnation of QI and blood.The pungent temperature rise of this product is loose, energy " the up head ", and wind-expelling pain-stopping, forefathers have saying of " headache not being from Rhizoma Chuanxiong ".Dispelling the wind and dampness pathogens arthromyodynia, limbs pain numbness, this product can " bypass passages through which vital energy circulates " expelling wind and activating blood circulation pain relieving." book on Chinese herbal medicine converges and says ": " acrid in the mouth sun, gas is apt to away alter and the state of the solidifying viscous of depletion of YIN, though enter blood system, can go again a wind cutting, adjusts all gas.”
Caulis Spatholobi: be the dry rattan of leguminous plant spatholobus suberectus (Radix seu Caulis Verntilaginis Leiocarpae, SANYE Caulis Spatholobi, nine layers of wind); Warm in nature, bitter in the mouth, sweet.Return Liver Channel.Can promoting the circulation of blood enrich blood, regulating menstruation, relaxing muscles and tendons and activating QI and blood in the collateral.The nourshing blood and promoting blood circulation of this product energy and relaxing muscles and tendons and activating QI and blood in the collateral, dispelling the wind and dampness pathogens arthralgia pain, arthralgia, numb limbs and tense tendons, joins medicine for rheumatism with using.Supplementary Amplifications of the Compendium of Materia Medica: " its rattan is invigorated blood circulation most, warm waist knee joint wind-phlegm." liana rubber " strengthening bone and muscle, caproic acid pain, and wine takes, punish-old people deficient qi and blood, the diseases such as numb hand and foot paralysis ".
Radix Salviae Miltiorrhizae: cold nature, bitter in the mouth.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, removing heat from blood eliminating carbuncle, calms the nerves.This product is the key medicine of blood circulation promoting and blood stasis dispelling.Dispelling the wind and dampness pathogens arthralgia pain, joins the medicine for rheumatism such as Radix Saposhnikoviae, Radix Gentianae Macrophyllae with using." with China's son book on Chinese herbal medicine ": " sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful.”
Radix Clematidis: the rhizome of ranunculaceae plant Radix Clematidis, Clematis hexapetala or northeast clematis etc.; Warm in nature, acrid in the mouth, salty.Return urinary bladder channel.Effect: wind-damp dispelling, the meridian dredging, the bone that disappears is choked.Its pungent loose temperature is logical, and property is apt to away suddenly, and the current twelve regular channels can wind-damp dispelling, and stopping numbness pain can stimulate the menstrual flow again.All rheumatic arthralgia, no matter apathy, all can use up and down, is rheumatic arthralgia key medicine." medicine justice ": " Radix Clematidis, property is suddenly anxious, is apt to away and does not keep the logical twelve channels and collaterals of a surname.Cure mainly in wind, wet, stagnant meridians of expectorant harmony, cause into gout migratory arthralgia caused by wind, arthralgia, swollen, or numb." modern study: this product has analgesia, antidiuretic activity.
Radix Glycyrrhizae: property is flat, sweet in the mouth.GUIXIN, lung, spleen, stomach warp.Effect: QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine." book on Chinese herbal medicine is just ": " property that must neutralize, has the merit of benefits of tune, separates its poison therefore poison obtains it, and just medicine obtains its property of sum, and what medicine administered to bring out the cold obtained helps outside it, put in poison delay its speed.Enter gas with gas medicine, enter blood with blood medicine, without toward can not, therefore claim state old.Modern study: this medicine has antiinflammatory, anti-allergic effects.
The Cortex Eucommiae: formal name used at school
eucommia ulmoides Oliver, have another name called bakelite, be Eucommiaceae plant; Warm in nature, sweet in the mouth.Return liver, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening effect.Be used for the treatment of lumbago due to renal deficiency, the disease such as unable and hypertension of muscles and bones.
Flos Carthami (Latin formal name used at school
carthamus tinctorius L.): Compositae, Flos Carthami platymiscium, warm in nature, acrid in the mouth.GUIXIN, Liver Channel.There is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain.Yong is in Zhi Liao mass in the abdomen mass in the abdomen, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, injury from falling down and the skin infection disease such as swell and ache.
Ramulus Cinnamomi, rectification of name: Cortex Cinnamomi (formal name used at school:
cinnamomum cassia Presl), have another name called beautiful osmanthus, Cortex cinnamomi japonici (Ramulus Cinnamomi) etc., belong to Ranales, the medium megaphanerophyte of Lauraceae; Warm in nature, acrid in the mouth, sweet.GUIXIN, lung, urinary bladder channel.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, effect of the peaceful gas that spins of supporing yang activating QI.For anemofrigid cold, coldness and pain in the epigastrium, arthralgia, phlegm retention, edema, the diseases such as cardiopalmus and renal mass.
The Radix Paeoniae Alba: Radix Paeoniae Alba (formal name used at school:
paeonia lactiflora Pall.), be Ranunculaceae Paeonia plant; Cold nature, bitter in the mouth, acid, return Liver Channel.There is nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant, nourishes blood and receives effect of the moon.Cure mainly the breast abdomen pain over the hypochondriac region, carpopedal spasm pain, feeling of fullness in the head, headache, dizzy, tinnitus, irritated irritability, spontaneous sweating, fever due to yin deficiency.
The traditional Chinese medical science is thought, deficiency of both the liver and kidney, it is the endogenous cause of ill of primary disease that muscles and bones mistake is supported, wound strain, wind-cold damp pathogen is the exopathogenic factor of primary disease, under the impact of exopathogenic factor, wind-cold damp pathogen is invaded Taiyang channel, causes sun operation to be defended and becomes estranged, QI-blood circulation is not smooth, passages through which vital energy circulates is retarded by silt, thereby produces stiff nape and back, the disease that the headache of shoulder arm numbness " dizzy " waits deficiency in origin and excess in superficiality.All belong to the categories such as Chinese medicine syndrome of blood stasis arthromyodynia, Treatment of Cervical Spondylosis in Traditional Chinese Medicine is with blood circulation promoting and blood stasis dispelling, and loose wind dehumidifies, removing obstruction in the collateral to relieve pain, and relaxing muscles and tendons bone strengthening is main.Radix Puerariae in side, cool in nature, acrid in the mouth, sweet, its effect expelling pathogenic factors from muscles promoting blood circulation and stopping pain, the kind stiff nape and back of controlling, and energy born fluid, Ru Yangjinmai, and its contracture of relaxing is the key medicine for the treatment of cervical spondylosis pain, it is also the most used medicine in treatment, in side, reuse the gas of Radix Puerariae energy yang invigorating expelling pathogenic factors from muscles, a surname's dredging DU Meridian pulse classic, be apt to control person's back unfavorable through acupoint, and the up disease institute that reaches of priming, excellent to improving headache effect.Radix Angelicae Sinensis is warm in nature, and acrid in the mouth, sweet is returned liver, the heart, spleen channel, and having enriches blood invigorates blood circulation, anti-inflammatory analgetic, effect of protection kidney." Jing Yue's complete work book on Chinese herbal medicine is just ": " Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood; Its gas is light and pungent, therefore again can promoting the circulation of blood.Invigorating middle warmer has, in row, has benefit, the really gas medicine in blood, and also the panacea in blood is also.Its effect, for enriching blood, is invigorated blood circulation, pain relieving, and the two is monarch drug altogether.The Cortex Eucommiae, warm in nature, sweet in the mouth, returns Liver and kidney warp, can invigorating the liver and kidney, bone and muscle strengthening.Radix Salviae Miltiorrhizae cold nature, bitter in the mouth, GUIXIN, Liver Channel, have promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, tonification liver.Two medicines share energy liver and kidney tonifying, activating blood circulation to dissipate blood stasis, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic.Caulis Spatholobi property is flat, and sweet in the mouth, returns spleen, stomach, urinary bladder channel, energy blood-supplementing blood-nourishing, and relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation to remove blood stasis, invigorating the kidney and strengthening the bones, inducing menstruation to relieve menalgia, is to control from void opinion.Flos Carthami is warm in nature, acrid in the mouth, and GUIXIN, Liver Channel, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, this is ministerial drug, and principal drug assistance is strengthened blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, liver and kidney tonifying, strong muscles and bones.Radix Clematidis, warm in nature, acrid in the mouth, property are apt to away, can wind-damp dispelling, the meridian dredging, stopping numbness pain, kind dispelling the wind and dampness pathogens brachialgia, numb limbs and tense tendons, joint joint stuffiness person; Ramulus Cinnamomi, warm in nature, acrid in the mouth, sweet, its effect warming the meridian for promoting the flow of YANG QI, expelling pathogenic factors from muscles is delivered, and the brachialgia of upper limb shoulder is the most suitable; Radix Paeoniae Alba cold nature, bitter in the mouth, acid, sweet, its effect nourishing blood to suppress the hyperactive liver, relieving spasm to stop pain, same better with analgesic effect with Radix Glycyrrhizae; Above three medicines are adjuvant drug.Radix Glycyrrhizae, property is flat, sweet in the mouth, effect coordinating the actions of various ingredients in a prescription, with for making medicine.This Chinese medicine preparation is taking blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain as main, invigorates blood circulation and blood trouble not, and residence is mended in logical, and reinforcement and elimination in combination has eliminating evil and do not hinder positive prescription feature.Said preparation goes its endogenous cause of ill with the wind dehumidifying of faling apart, and with blood circulation promoting and blood stasis dispelling Zhi Qiben, controls its mark with muscles and tendons relaxing to alleviate pain, thereby reaches the object for the treatment of cervical spondylosis.
Theory of Chinese medical science is thought " have Zhu Nei and must shape all outer ".Symptom, the sign of cervical spondylosis are varied, and patient's subjective symptoms is more, and sings and symptoms presents parallel dependency with the order of severity of cervical spondylosis.Although Chinese medicine can not melt bony spur, dissolves vertebral pulp, even can not make CT or MRI morphology change, its alleviating pain, has the effect that improves clinical symptoms and sign, is but the conclusive fact.
The treatment mechanism of this Chinese medicine preparation is as follows:
(1), improve microcirculation, elimination contrafluxion edema.
The clinical symptoms of cervical spondylosis and body card can have outthrust extruding or tractive neural axon and anterior horn cell to cause, also can be due to extruding perforating branches or pia vessels Cong Shi nervous tissue microcirculation disturbance, and ischemia, anoxia and expand infringement.Meanwhile, the mechanical pressure axoplasmic flow in root that can affect the nerves, causes neuro humor running obstacle, particularly neural in the pressurized deformity of vascular bed, caused nutrient flow in nerve root to be obstructed, cause microcirculation disturbance.A large amount of Clinical and experimental studies show that microcirculation disturbance plays outbalance effect in the pathological change process of primary disease.Primary disease is relevant with microcirculation and hemorheology obstacle.Local inflammatory response, hyperemia, edema cause that blood fortune is obstructed, histanoxia, venous return obstacle and occur microcirculation disturbance, make metabolite organize inner accumulated, the local content concn of algogenic substance (inflammatory mediator) raises, particularly cause gathering and nerve root inflammatory exudate of nervous tissue's intracellular metabolite product, the major reason that inflammatory mediator gathers.The release of the inflammatory induced pain factor and occur pain.Modern medicine thinks that cervical spondylosis is because the Enrichment of sclerotin stimulation and metabolite (as Endothelin) causes vasospasm, affecting blood supplies, transverse foramen is congestion and edema around, transverse foramen is diminished relatively, extruding nerve root, vertebra degeneration of intervertebral disc, transverse process pitch smaller, make neural itself increase with its peripheral blood circulating resistance, sludging.This is consistent with the traditional Chinese medical science to the understanding of primary disease pathogenesis.Under the state of caused by liver and kidney deficiency, insufficiency of vital energy and blood, feel again that wind-cold damp pathogen or chronic strain cause wind chill blockage blood vessels, even qi depression to blood stasis, passages through which vital energy circulates are not smooth.This research shows, this product Chinese medicine preparation has the microcirculatory effect of improvement, and its effect is mainly manifested in following two aspect: l, improves micro-blood flow.By removing vasospasm and reducing blood viscosity resistance of blood flow and achieve the goal.After treatment, microcirculation improves, and first shows as micro-improving blood flow, and the micro-blood flow slowly that makes to flow accelerates.2, capillary permeability reduces.In accelerating blood flow, do not reduce the effective ingredient of blood, do not reduce and even increase endovascular osmotic pressure,effective, blood capillary around oozing of blood reduces or disappears.
(2), improve the effect of hemorheological property
Hemorheology is mobility and the viscosity of research blood, and microcirculation has close contact.As there is abnormal, slow blood flow in the viscosity of blood, cause general or locality circulatory disturbance, can there is ischemia, anoxia just organize, cause physiological function unbalance, even there is irreversible pathological change.Be exactly microcirculatory pathological change from macroscopic view.Therefore the developing of hemorheology and numerous disease, change and have close contacting.Experimental result is found the blood viscosity of Patients with Cervical Spondylopathy, and packed cell volume all increases than normal person, and great mass of data shows that again hemorheological improvement has parallel dependency with the remission of cervical spondylosis.This product has the effect that improves whole blood viscosity and packed cell volume of significance.
In a word, radicular symptom modern study thinks due to the inflammation of the compressing of physical property, chemical, local immunoreation more, stimulates and makes nerve root hyperemia, edema, microcirculation disturbance or neural infringement etc. produce symptom.The experimental research achievements of passing through, recognize why Chinese medicine has good therapeutical effect, just because of it can improve blood circulation, the elimination edema of nerve root, stop the nerve root release of local inflammation medium, algogenic substance around, promote absorption that it is dissipated, promoted neural regeneration and the recovery of function.
The acute and chronic toxicity test of this Chinese medicine preparation is as follows:
The various Chinese medicinal components that the present invention selects all meet the regulation of the Drug Administration Law of People's Republic of China, and said preparation is nontoxic to human body.Show through the acute and chronic toxicity test of animal, underproof animal, is showed no any toxic reaction, and its main organs has no significant change, and therefore said preparation is safe and reliable.
The observation of curative effect of this Chinese medicine preparation is reported as follows:
JINGFUKANG KELI is the current main product of the treatment cervical spondylosis of listing, is also the best product of market sales volume in like product at present.In order to show the therapeutic effect of medicine of the present invention to treatment cervical spondylosis, medicine of the present invention and JINGFUKANG KELI clinical experiment result curative effect are compared as follows:
(
1), diagnostic criteria: tcm diagnosis standard, macroscopic examination: nape pain, upper myasthenia of limbs, point numb, lower limb are weak, difficulty in walking, dizziness, feel sick, vomiting, even blurred vision, tachycardia and dysphagia etc., doctor trained in Western medicine film making checks, is diagnosed as cervical spondylosis according to x-ray fluoroscopy or CT detection.
(2), Therapeutic Method: capsule of the present invention is provided by Shanxi Normal University's pharmaceutical preparation chamber.Specification is 0.25 gram/60.Instructions of taking: take every day 3 times, each 3 15th is a course for the treatment of, generally takes for 2～3 courses for the treatment of.
(3) curative effect judging standard
Clinical cure: original sings and symptoms disappears, and neck, limb functional recover are normally worked.
Effective: cardinal symptom is obviously alleviated, sign is most of to disappear, and function is recovered normally, can participate in routine work substantially.
Effective: original symptom alleviates, neck, limb function part recover normal.
Invalid: before and after treatment, symptom, sign are without improving or increasing the weight of.
(4) result of the test
In cervical spondylosis 75 examples, cure 59 examples, effective 9 examples, effective 5 examples, invalid 2 examples, cure rate 78.6%, total effective rate 97.3%." JINGFUKANG KELI " curative effect of this product and bibliographical information is relatively in table 1.
The observation of curative effect comparison of this product of table 1 and JINGFUKANG KELI treatment cervical spondylosis
[1] old peace, JINGFUKANG KELI coordinates Manipulation cervical spondylosis 33 examples, medical forward position, 2013.19:194.
[2] Miao Tonghe, JINGFUKANG KELI treatment cervical spondylotic radiculopathy 56 examples, Hunan Journal of Traditional Chinese Medicine, 2011.27(5): 36.
[3] Ma Zhengming, the routine clinical observation on the therapeutic effect of JINGFUKANG KELI treatment cervical spondylotic radiculopathy 197, Chinese Medicine guide, 2012.10(21): 237-238.
[4] Ma little Jun, brilliant profit. JINGFUKANG KELI treatment ankylosing spondylitis cervical pain 60 examples. practical tcm internal medicine magazine, 2011.25(2): 67-68.
As can be seen from Table 1, this product treatment cervical spondylosis is evident in efficacy, treating both the principal and secondary aspects of a disease, is no matter that cure rate or effective percentage are all higher than like product JINGFUKANG KELI.
The present invention is reasonable in design, select above-mentioned raw material of Chinese medicine to combine and adopt modern technologies that the effective ingredient in Chinese medicine and elite part are extracted and refined, gained capsule preparations has blood circulation promoting and blood stasis dispelling, anti-inflammatory and antalgic, tonifying liver kidney tonifying, improves microcirculatory effect, thereby improve neck portion blood circulation, eliminate edema, stop the release of local inflammation medium, algogenic substance around of neck portion, promote absorption that it is dissipated, promoted neural regeneration and the recovery of function.Therefore the combination of pharmaceutical formulation of the present invention is rational, science, effective, the capsule preparations treatment cervical spondylosis good effect of developing, and instant effect, is difficult for recurrence, treating both the principal and secondary aspects of a disease, and easy to carry and use.
model case is as follows:
1, Mr. Zhu, man, 43 years old, area just outside a city gate people from town, Yicheng County, Shanxi Province, within 2007, in long-term startup procedure, gradually feeling that neck hardens turns sour, and CT examination is diagnosed as makes a definite diagnosis hyperosteogeny.After increase the weight of gradually, develop in one's hands numb, the dimness of vision.Start to take this product in March, 2013, after taking medicine 3 days, feels that neck is brisk, and after 1 course for the treatment of, neck rotates flexibly, 2 the course for the treatment of numbness of hand sensation obviously alleviate, eyes are also felt not felt bad, see thing also clear how, after 3 courses for the treatment of, all symptoms all disappear, and follow up a case by regular visits to, and have no recurrence.
2, Mrs Qiao, 43 years old, Linfen, Shanxi Province from Yaodu District, prominent sense of in April, 2003 hands is numb, CT examination is diagnosed as cervical curvature and straightens, after develop into neck and harden, arm is numb, to such an extent as to right hand finger joint style can not stretch, cannot normally go to work, the rest of can only being in.The treatment of employing various ways, DeGrain.Start to take this product in April, 2013, takes medicine after 1 course for the treatment of, and symptom is alleviated to some extent, and sensation whole body is comfortable brisk suddenly in the 5th day of the 2nd course for the treatment of, and neck is flexible, and the sensation of numbness of hand has been alleviated.After the 3rd course for the treatment of, right hand articulations digitorum manus can stretch, and the sensation of hands and arm fiber crops obviously alleviates, good day by day with aftersensation, and after 4 courses for the treatment of, all symptoms all disappear, and follow up a case by regular visits to, and have no recurrence.
3, Mr. Li, 48 years old, Linfen, Shanxi Province from Yaodu District, started morbidity for 2006, sensation headache, the dimness of vision.CT examination is diagnosed as prolapse of cervical intervertebral disc.Rear development numb swelling in one's hands, evening, pain cannot be fallen asleep, and started to take this product in May, 2013, after 1 course for the treatment of, had a headache and obviously alleviated, and eyes are much more comfortable, see that thing is also seen clear, and after 2 courses for the treatment of, all symptoms all disappear, and follow up a case by regular visits to, and have no recurrence.
4, Mr. Wang, 59 years old, Shanxi Province that makes the county prosperous Lvliang City, feel in March, 2013 neck harden, have a headache, dizzy, feel sick, CT examination is diagnosed as hyperosteogeny of cervical vertebra, by Duo Jia hospital and Drug therapy all to no effect, start to take in April, 2013 after 1 course for the treatment of of this product, neck hardens, dizzy, nauseating symptom is obviously alleviated, and after 2 courses for the treatment of, all symptoms all disappear, follow up a case by regular visits to, have no recurrence.
5, Mrs Li, 42 years old, the worker of Beijing Ai Nong household services company, within 2012, gradually feeling that neck is felt bad hardens, CT examination is diagnosed as hyperosteogeny, after increase the weight of gradually to develop into shoulder pain, impact is working normally.Start to take this product in May, 2013, one the course for the treatment of aftersensation, how neck has rotated flexibly, both shoulders pain relief, after 2 courses for the treatment of, all symptoms all disappear, and follow up a case by regular visits to, and have no recurrence.
Detailed description of the invention
Below specific embodiments of the invention are elaborated.
embodiment 1
Treat a Chinese medicine formula for cervical spondylosis, formed by following component and mass fraction proportioning: (every part of 1g)
20 parts of Radix Puerariaes, 25 parts of Rhizoma Chuanxiongs, 18 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts of the Radix Paeoniae Albas, 25 parts of Radix Clematidis, 25 parts of the Cortexs Eucommiae, 20 parts of Caulis Spatholobis, 18 parts of Radix Salviae Miltiorrhizaes,, 20 parts of Ramulus Cinnamomi, 10 parts, Flos Carthami, 17 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), take each crude drug by proportion by weight;
(2), above-mentioned raw materials medicine is broken into 20 object coarse powder,, by 60% soak with ethanol of 5 times of amounts 24 hours, reflux 3 hours, collects one time extracting solution;
(3) add, again 60% the alcohol heating reflux 2 hours of 2 times of amounts, collect secondary raffinate;
(4), filter after merging above-mentioned secondary raffinate, in filtrate, add ZTC-Ι natural clarifying agent by 0.2%, after fully stirring, filter, concentrating under reduced pressure becomes fluid extract, dries and obtains dry extract afterwards at 60 DEG C;
(5) add medicine dispersant and adjuvant after dry extract being broken into 100 object fine powders, fill and be prepared into capsule.
embodiment 2
Treat a Chinese medicine formula for cervical spondylosis, formed by following component and mass fraction proportioning: (every part of 10g)
25 parts of Radix Puerariaes, 20 parts of Rhizoma Chuanxiongs, 25 parts of the Radixs Astragali, 23 parts of Radix Angelicae Sinensis, 25 parts of the Radix Paeoniae Albas, 20 parts of Radix Clematidis, 18 parts of the Cortexs Eucommiae, 25 parts of Caulis Spatholobis, 15 parts of Radix Salviae Miltiorrhizaes,, 10 parts of Ramulus Cinnamomi, 20 parts, Flos Carthami, 15 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), take each crude drug by proportion by weight;
(2), above-mentioned raw materials medicine is broken into 20 object coarse powder,, by 65% soak with ethanol of 4 times of amounts 18 hours, reflux 4 hours, collects one time extracting solution;
(3) add, again 70% the alcohol heating reflux 2 hours of 4 times of amounts, collect secondary raffinate;
(4), filter after merging above-mentioned secondary raffinate, in filtrate, add ZTC-III natural clarifying agent by 0.1%, after fully stirring, filter, concentrating under reduced pressure becomes fluid extract, dries and obtains dry extract afterwards at 50 DEG C;
(5) add medicine dispersant and adjuvant after dry extract being broken into 80 object fine powders, fill and be prepared into capsule.
embodiment 3
Treat a Chinese medicine formula for cervical spondylosis, formed by following component and mass fraction proportioning: (every part of 15g)
30 parts of Radix Puerariaes, 30 parts of Rhizoma Chuanxiongs, 15 parts of the Radixs Astragali, 25 parts of Radix Angelicae Sinensis, 18 parts of the Radix Paeoniae Albas, 15 parts of Radix Clematidis, 12 parts of the Cortexs Eucommiae, 22 parts of Caulis Spatholobis, 10 parts of Radix Salviae Miltiorrhizaes,, 13 parts of Ramulus Cinnamomi, 15 parts, Flos Carthami, 20 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), take each crude drug by proportion by weight;
(2), above-mentioned raw materials medicine is broken into 20 object coarse powder,, by 70% soak with ethanol of 5 times of amounts 16 hours, reflux 3 hours, collects one time extracting solution;
(3) add, again 60% the alcohol heating reflux 2 hours of 2 times of amounts, collect secondary raffinate;
(4), filter after merging above-mentioned secondary raffinate, in filtrate, add ZTC-II natural clarifying agent and 0.3%ZTC-IV natural clarifying agent by 0.2%, after fully stirring, filter, concentrating under reduced pressure becomes fluid extract, dries and obtains dry extract afterwards at 60 DEG C;
(5) add medicine dispersant and adjuvant after dry extract being broken into 100 object fine powders, fill and be prepared into capsule.
embodiment 4
Treat a Chinese medicine formula for cervical spondylosis, formed by following component and mass fraction proportioning: (every part of 20g)
15 parts of Radix Puerariaes, 22 parts of Rhizoma Chuanxiongs, 20 parts of the Radixs Astragali, 20 parts of Radix Angelicae Sinensis, 12 parts of the Radix Paeoniae Albas, 20 parts of Radix Clematidis, 20 parts of the Cortexs Eucommiae, 15 parts of Caulis Spatholobis, 20 parts of Radix Salviae Miltiorrhizaes,, 15 parts of Ramulus Cinnamomi, 18 parts, Flos Carthami, 10 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), take each crude drug by proportion by weight;
(2), above-mentioned raw materials medicine is broken into 30 object coarse powder,, by 60% soak with ethanol of 6 times of amounts 24 hours, reflux 3 hours, collects one time extracting solution;
(3) add, again 60% the alcohol heating reflux 3 hours of 3 times of amounts, collect secondary raffinate;
(4), filter after merging above-mentioned secondary raffinate, add 0.2% ZTC-III natural clarifying agent and 0.2% ZTC-Ι natural clarifying agent in filtrate, after fully stirring, filter, concentrating under reduced pressure becomes fluid extract, dries and obtains dry extract afterwards at 55 DEG C;
(5) add medicine dispersant and adjuvant after dry extract being broken into 80 object fine powders, fill and be prepared into capsule.
embodiment 5
Treat a Chinese medicine formula for cervical spondylosis, formed by following component and mass fraction proportioning: (every part of 20g)
25 parts of Radix Puerariaes, 20 parts of Rhizoma Chuanxiongs, 15 parts of the Radixs Astragali, 20 parts of Radix Angelicae Sinensis, 20 parts of the Radix Paeoniae Albas, 20 parts of Radix Clematidis, 20 parts of the Cortexs Eucommiae, 15 parts of Caulis Spatholobis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Ramulus Cinnamomi, 10 parts, Flos Carthami, 10 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), take each crude drug by proportion by weight;
(2), above-mentioned raw materials medicine is broken into 30 object coarse powder,, by 60% soak with ethanol of 6 times of amounts 24 hours, reflux 3 hours, collects one time extracting solution;
(3) add, again 60% the alcohol heating reflux 3 hours of 3 times of amounts, collect secondary raffinate;
(4), filter after merging above-mentioned secondary raffinate, add 0.1% ZTC-IV natural clarifying agent and 0.3% ZTC-Ι natural clarifying agent in filtrate, after fully stirring, filter, concentrating under reduced pressure becomes fluid extract, dries and obtains dry extract afterwards at 55 DEG C;
(5) add medicine dispersant and adjuvant after dry extract being broken into 80 object fine powders, fill and be prepared into capsule.
Claims (4)
1. a Chinese medicine formula for the treatment of cervical spondylosis, is characterized in that: be made up of following component and quality proportioning:
15～30 parts of Radix Puerariaes, 20～30 parts of Rhizoma Chuanxiongs, 15～25 parts of the Radixs Astragali, 15～25 parts of Radix Angelicae Sinensis, 12～25 parts of the Radix Paeoniae Albas, 15～30 parts of Radix Clematidis, 12～25 parts of the Cortexs Eucommiae, 15～25 parts of Caulis Spatholobis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Ramulus Cinnamomi, 10～20 parts, Flos Carthami, 10～20 parts, Radix Glycyrrhizae.
2. the Chinese medicine formula for the treatment of cervical spondylosis according to claim 1, is characterized in that: be made up of following component and quality proportioning:
25 parts of Radix Puerariaes, 20 parts of Rhizoma Chuanxiongs, 15 parts of the Radixs Astragali, 20 parts of Radix Angelicae Sinensis, 20 parts of the Radix Paeoniae Albas, 20 parts of Radix Clematidis, 20 parts of the Cortexs Eucommiae, 15 parts of Caulis Spatholobis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Ramulus Cinnamomi, 10 parts, Flos Carthami, 10 parts, Radix Glycyrrhizae.
3. a preparation method for the treatment of the Chinese medicinal capsule preparation of cervical spondylosis, is characterized in that: comprise the steps:
(1), formula according to claim 1 and 2 takes each component raw material medicine;
(2), above-mentioned raw materials medicine is broken into 20～40 object coarse powder,, by the soak with ethanol of 50～70 % of 4～6 times of amounts 12～24 hours, reflux 2～3 hours, collects one time extracting solution;
(3) add, again 50～70% alcohol heating reflux 2～3 hours of 2～4 times of amounts, collect secondary raffinate;
(4), filter after merging above-mentioned secondary raffinate, add 0.1～0.5% sedimentation agent of filtrate weight in filtrate, after stirring, filter, filtrate decompression is condensed into fluid extract, dries and obtains dry extract afterwards at 50～60 DEG C;
(5) by adding medicine dispersant and adjuvant after dry extract pulverizing, fill and be prepared into capsule.
4. the preparation method of the Chinese medicinal capsule preparation for the treatment of cervical spondylosis according to claim 3, it is characterized in that: in step (4), described sedimentation agent is a kind of or any two kinds of mixing with arbitrary proportion in ZTC-Ι natural clarifying agent, ZTC-II natural clarifying agent, ZTC-III natural clarifying agent, ZTC-IV natural clarifying agent.
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| CN108785497A (en) * | 2018-09-03 | 2018-11-13 | 刘亚莉 | A kind of ointment and preparation method thereof for treating bone and joint diseases |
| CN110151858A (en) * | 2019-07-10 | 2019-08-23 | 杜黎明 | A kind of Chinese materia medica preparation for treating cervical spondylosis |
| CN110269906A (en) * | 2019-08-07 | 2019-09-24 | 河南省神州神药业有限公司 | A kind of dedicated liquid medicine alleviated and promote rehabilitation of osteopathy |
| CN114668801A (en) * | 2022-04-14 | 2022-06-28 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating cervical spondylosis and preparation method and application thereof |
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| CN114668801A (en) * | 2022-04-14 | 2022-06-28 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating cervical spondylosis and preparation method and application thereof |
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