CN102940851A - Traditional Chinese medicine dispersible tablet for cervical spondylosis and preparation method thereof - Google Patents
Traditional Chinese medicine dispersible tablet for cervical spondylosis and preparation method thereof Download PDFInfo
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- CN102940851A CN102940851A CN 201210445682 CN201210445682A CN102940851A CN 102940851 A CN102940851 A CN 102940851A CN 201210445682 CN201210445682 CN 201210445682 CN 201210445682 A CN201210445682 A CN 201210445682A CN 102940851 A CN102940851 A CN 102940851A
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Abstract
The invention discloses a traditional Chinese medicine dispersible tablet for cervical spondylosis and a preparation method thereof. The tablet comprises the following raw material medicine components in parts by weight: 15 parts of ligusticum chuanxiong, 30 parts of astragalus mongholicus, 10 parts of cassia twig, 15 parts of notopterygium root, 20 parts of Chinese Angelica, 15 parts of radix paeoniae alba, 15 parts of turmeric, 10 parts of ramulus mori, 15 parts of salvia miltiorrhiza, 5 parts of asarum, 15 parts of caulis spatholobi, 15 parts of safflower carthamus, 15 parts of poria cocos, and 10 parts of liquorice. According to the invention, the fourteen medicines are prepared into dry paste powder; and the weight percentage between the dry paste powder and the raw auxiliary materials is that: 51.8 parts of dry paste powder, 10 parts of sodium carboxymethyl starch, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline cellulose , 0.5 parts of magnesium stearate, 0.5 parts of aerosil and 50 parts of ethanol. Compared with the existing product with the related functions, the traditional Chinese medicine dispersible tablet has the advantages of small dose, convenience for taking, rapid absorption, high bioavailability, convenience to carry, exact quantification, and stable quality without adverse reaction and drug resistance.
Description
Technical field
The invention belongs to the Chinese medicine field of pharmaceutical technology, particularly a kind of dispersible tablets of Chinese medicine for cervical spondylosis and preparation method thereof.
Background technology
The existing treatment cervical spondylosis of existing market.Be used for warming YANG and invigorating QI, the oral solid formulation product of channels sootheing and network vessel quickening, the difficulty of taking medicine, it is long to reach the effective blood drug concentration time, carries inconvenience, and dosage is large, and medicining times is many, and the time is long.
Summary of the invention
The purpose of this invention is to provide a kind of dispersible tablets of Chinese medicine for cervical spondylosis and preparation method thereof, the treatment cervical spondylosis, use warming YANG and invigorating QI, channels sootheing and network vessel quickening, and taking dose is little, taking convenience, absorption is fast, bioavailability is high, easy to carry, quantitatively accurately, steady quality.
Technical scheme of the present invention is: design a kind of dispersible tablets of Chinese medicine for cervical spondylosis, it is characterized in that crude drug composition and weight proportion thereof that it contains are: 15 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 10 parts of Ramulus Cinnamomi, 15 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Sinensis, 15 parts of the Radix Paeoniae Albas, 15 parts in Rhizoma Curcumae Longae, 10 parts of Ramulus Moris, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Asaris, 15 parts of Caulis Spatholobis, 15 parts on Flos Carthami, 15 parts in Poria, 10 parts of ten four Chinese medicines such as grade of Radix Glycyrrhizae are the solid preparation of effective ingredient; Above-mentioned ten four Chinese medicines are made dried cream powder, and dried cream powder and supplementary material weight proportion thereof are: 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of micropowder silica gel, 50 parts of ethanol.
The preparation method of described a kind of dispersible tablets of Chinese medicine for cervical spondylosis is characterized in that it may further comprise the steps:
1) by following weight ratio weighting raw materials: 15 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 10 parts of Ramulus Cinnamomi, 15 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Sinensis, 15 parts of the Radix Paeoniae Albas, 15 parts in Rhizoma Curcumae Longae, 10 parts of Ramulus Moris, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Asaris, 15 parts of Caulis Spatholobis, 15 parts on Flos Carthami, 15 parts in Poria, 10 parts in Radix Glycyrrhizae;
2) 14 flavor Chinese crude drugs in the above raw material decoct with water twice, and collecting decoction filters, and filtrate is concentrated into the thick paste of relative density 1.28-1.30, and 60 mesh sieves were pulverized in 80 ℃ of forced air dryings, became dried cream powder for subsequent use;
3) dried cream powder and the following adjuvant with step 2 takes by weighing by following weight proportion: 50 parts of 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of micropowder silica gel and ethanol, cross 60 mesh sieves;
4) with the dried cream powder of the above-mentioned weight portion of step 3, with carboxymethyl starch sodium, polyvinylpolypyrrolidone and microcrystalline Cellulose mix homogeneously, with ethanol soft material processed;
5) 14 mesh sieves are granulated, 50-60 ℃ of forced air drying;
6) 14 mesh sieve granulate remain adjuvant, mix homogeneously in the adding step 3;
7) tabletting gets final product.
Advantage of the present invention is: monarch drug Rhizoma Chuanxiong among the we, original name rhizome of chuanxiong Qiong., be usually used in blood-activating and qi-promoting, wind-expelling pain-stopping is walked and is not kept, can go loose, the up top, mountain peak that reaches; Enter again blood system, the descending sea of blood that reaches.The blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various diseases of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia; The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " record: " main carbuncle loses skin ulcer for a long time, the evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help the gas strengthening bone and muscle, put on flesh and enrich blood; The Ramulus Cinnamomi expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.The main air exterior syndrome of trembling with fear; Arthralgia due to cold-dampnes; Extreme cold of the limbs; The amenorrhea dysmenorrhea; The lump in the abdomen caking; The thoracic obstruction; Cardiopalmus, phlegm retention; Dysuria.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass; Rhizoma Et Radix Notopterygii, loose exterior cold; Wind-damp dispelling; Sharp joint; Pain relieving.Main affection of exogenous wind-cold; It is lossless to have a headache; Mimeograph cold-damp numbness; The edema due to wind pathogen edema; Sore swollen toxin; Radix Angelicae Sinensis proves with advanced technologies such as counter immunoelectrophoresis, isotopic tracing and Electronic Speculum at present, and Radix Angelicae Sinensis can make that the Hepatocyte matter of In vitro culture is synthetic to be increased, and DNA, RNA synthetic had facilitation.Clinical confirmation, Radix Angelicae Sinensis can make patient's thymol turbidity reduce.The Radix Angelicae Sinensis meals are raised mice, and the hepatic tissue endogenous is breathed and strengthened, and the ability of oxidation glutamic acid significantly improves.Hepatic injury due to the carbon tetrachloride there is protective effect, and can prevents that liver glycogen from reducing.Experiment and clinical all proofs, Radix Angelicae Sinensis has effect for reducing blood fat to hyperlipemia, and its effect is similar with medicines such as clofibrates.2.3-diphosphonic acid generation in animal and human's isolated cells there is facilitation, reduces the affinity of hemoglobin and oxygen, promote band oxygen hemoglobin in tissue, to discharge oxygen, thereby increased the function of erythrocyte transportation oxygen.
Chinese medicine composition capsule taking dose of the present invention is little, taking convenience, absorption is fast, bioavailability is high, easy to carry, quantitatively accurately, steady quality.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
Embodiment
A kind of dispersible tablets of Chinese medicine for cervical spondylosis and preparation method thereof adopts following steps to make:
1) by following weight ratio weighting raw materials: Rhizoma Chuanxiong 15g, Radix Astragali 30g, Ramulus Cinnamomi 10g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 15g, Rhizoma Curcumae Longae 15g, Ramulus Mori 10g, Radix Salviae Miltiorrhizae 15g, Herba Asari 5g, Caulis Spatholobi 15g, Flos Carthami 15g, Poria 15g, Radix Glycyrrhizae 10g;
2) 14 flavor Chinese crude drugs in the above raw material decoct with water twice, and collecting decoction filters, and filtrate is concentrated into the thick paste of relative density 1.28-1.30, and 60 mesh sieves were pulverized in 80 ℃ of forced air dryings, became dried cream powder for subsequent use;
3) dried cream powder and the following adjuvant with step 2 takes by weighing by following weight proportion: dried cream powder 51.8g, carboxymethyl starch sodium 10g, polyvinylpolypyrrolidone 13.2g, microcrystalline Cellulose 24g, magnesium stearate 0.5g, micropowder silica gel 0.5g and ethanol 50g, cross 60 mesh sieves;
4) with the dried cream powder of the above-mentioned weight of step 3, with carboxymethyl starch sodium, polyvinylpolypyrrolidone and microcrystalline Cellulose mix homogeneously, with ethanol soft material processed;
5) 14 mesh sieves are granulated, 50-60 ℃ of forced air drying;
6) 14 mesh sieve granulate remain adjuvant, mix homogeneously in the adding step 3;
7) tabletting gets final product.
This clinical observation that is used for the treatment of the pure Chinese medicine combination capsule for treating cervical spondylosis of apoplexy of the embodiment of the invention
1 data and method
1.1 physical data
Patients with Cervical Spondylopathy 80 examples that selection is received treatment voluntarily are divided at random treatment group 1, treatment group 2, treatment group 3 and matched group and are respectively 20 examples, 12 of every group of men for the treatment of group, 8 of woman; Age between 28 1 60, average 44 years old; 11 of matched group men, 9 of woman; Four groups of patient age symptoms consist of without significant difference, and disease time is the longest 5 years, the shortest January.Has comparability (P〉0.05).
1.2 Therapeutic Method
Two groups of Primary Cares are consistent, and matched group is not taken medicine.Treatment group 1 embodiment of the invention Chinese medicine composition, three of every days twice, one time, 10 ~ 15 is a course for the treatment of.Treatment group 2 usefulness Chengde Pharmaceutical JINGFUKANG KELI, the Gucining eapsule for the treatment of group 3 usefulness Shaanxi cloud Chinese medicinal material industries.Not medication of matched group.
2 results
2.1 curative effect determinate standard
Clinical cure: clinical symptoms all disappears, and activity does not affect working and learning freely, with examining 2 months without recurring: produce effects; Symptom and sign disappear substantially, only have slightly in fatigue or Changes in weather
Symptom does not affect work and life: take a turn for the better; Sx↓, sign is improved, but recurrence is arranged, and is influential to people's load operation: invalid; Symptom and sign is without obviously improving or increasing the weight of.
2.2 therapeutic outcome
Cure | Produce effects | Take a turn for the better | Invalid | Effective percentage | |
Treatment group 1 | 9 | 6 | 4 | 1 | 95% |
Treatment group 2 | 7 | 7 | 4 | 2 | 90% |
Treatment group 3 | 6 | 8 | 3 | 3 | 85% |
Matched group | 0 | 0 | 0 | 20 | 0% |
3 discuss
The traditional Chinese medical science thinks that the main pathogenesis of cervical spondylosis is Liver and kidney ten thousand void, and marrow is not enough, and QI and blood declines few, and neck bone loses in moistening foster, and wind-cold damp pathogen is easy to invasion and attack, and numbness meridians, qi depression to blood stasis.Adopt Chinese medicine to import administration, the softening the hard mass collateral dredging, invigorating blood circulation addiction promoting local metabolism, thereby absorbs body and eliminates the hypertrophy that oneself forms, and reaches the healing purpose.And then prescription is reliably effective under illustrating in this invention.
Claims (2)
1. a dispersible tablets of Chinese medicine that is used for cervical spondylosis is characterized in that crude drug composition and weight proportion thereof that it contains are: 15 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 10 parts of Ramulus Cinnamomi, 15 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Sinensis, 15 parts of the Radix Paeoniae Albas, 15 parts in Rhizoma Curcumae Longae, 10 parts of Ramulus Moris, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Asaris, 15 parts of Caulis Spatholobis, 15 parts on Flos Carthami, 15 parts in Poria, 10 parts of ten four Chinese medicines such as grade of Radix Glycyrrhizae are the solid preparation of effective ingredient; Above-mentioned ten four Chinese medicines are made dried cream powder, and dried cream powder and supplementary material weight proportion thereof are: 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of micropowder silica gel, 50 parts of ethanol.
2. the preparation method of a kind of dispersible tablets of Chinese medicine for cervical spondylosis according to claim 1 is characterized in that it may further comprise the steps:
1) by following weight ratio weighting raw materials: 15 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 10 parts of Ramulus Cinnamomi, 15 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Sinensis, 15 parts of the Radix Paeoniae Albas, 15 parts in Rhizoma Curcumae Longae, 10 parts of Ramulus Moris, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Asaris, 15 parts of Caulis Spatholobis, 15 parts on Flos Carthami, 15 parts in Poria, 10 parts in Radix Glycyrrhizae;
2) 14 flavor Chinese crude drugs in the above raw material decoct with water twice, and collecting decoction filters, and filtrate is concentrated into the thick paste of relative density 1.28-1.30, and 60 mesh sieves were pulverized in 80 ℃ of forced air dryings, became dried cream powder for subsequent use;
3) dried cream powder and the following adjuvant with step 2 takes by weighing by following weight proportion: 50 parts of 51.8 parts of dried cream powders, 10 parts of carboxymethyl starch sodium, 13.2 parts of polyvinylpolypyrrolidone, 24 parts of microcrystalline Cellulose, 0.5 part of magnesium stearate, 0.5 part of micropowder silica gel and ethanol, cross 60 mesh sieves;
4) with the dried cream powder of the above-mentioned weight portion of step 3, with carboxymethyl starch sodium, polyvinylpolypyrrolidone and microcrystalline Cellulose mix homogeneously, with ethanol soft material processed;
5) 14 mesh sieves are granulated, 50-60 ℃ of forced air drying;
6) 14 mesh sieve granulate remain adjuvant, mix homogeneously in the adding step 3;
7) tabletting gets final product.
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103784530A (en) * | 2014-02-26 | 2014-05-14 | 王传林 | Traditional Chinese medicine for treating cervical spondylosis and preparation method thereof |
CN103948869A (en) * | 2014-05-05 | 2014-07-30 | 苏玉琴 | Traditional Chinese medicament for treating cervical vertebra radiculitis |
CN103961424A (en) * | 2014-06-04 | 2014-08-06 | 杜黎明 | Traditional Chinese medicine formula for treating cervical spondylosis and preparation method of traditional Chinese medicine capsule preparation |
CN104042692A (en) * | 2014-06-23 | 2014-09-17 | 任德标 | Fumigating medicine for treating neck-shoulder and lumbocrural pain |
CN104338089A (en) * | 2014-11-14 | 2015-02-11 | 吴永龙 | Medicament for treating cervical spondylosis and preparation method thereof |
CN114272284A (en) * | 2022-01-18 | 2022-04-05 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating blood stasis blocking type bone rheumatism, preparation and application |
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2012
- 2012-11-09 CN CN 201210445682 patent/CN102940851A/en not_active Withdrawn
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103784530A (en) * | 2014-02-26 | 2014-05-14 | 王传林 | Traditional Chinese medicine for treating cervical spondylosis and preparation method thereof |
CN103948869A (en) * | 2014-05-05 | 2014-07-30 | 苏玉琴 | Traditional Chinese medicament for treating cervical vertebra radiculitis |
CN103961424A (en) * | 2014-06-04 | 2014-08-06 | 杜黎明 | Traditional Chinese medicine formula for treating cervical spondylosis and preparation method of traditional Chinese medicine capsule preparation |
CN103961424B (en) * | 2014-06-04 | 2016-06-01 | 杜黎明 | A kind of treat the Chinese medicine formula of cervical spondylosis and the preparation method of capsule preparations thereof |
CN104042692A (en) * | 2014-06-23 | 2014-09-17 | 任德标 | Fumigating medicine for treating neck-shoulder and lumbocrural pain |
CN104042692B (en) * | 2014-06-23 | 2016-08-17 | 任德标 | A kind of fumigating medicine treating neck-shoulder pain, lumbago and leg pain |
CN104338089A (en) * | 2014-11-14 | 2015-02-11 | 吴永龙 | Medicament for treating cervical spondylosis and preparation method thereof |
CN114272284A (en) * | 2022-01-18 | 2022-04-05 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating blood stasis blocking type bone rheumatism, preparation and application |
CN114272284B (en) * | 2022-01-18 | 2023-01-31 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating blood stasis blocking type bone rheumatism, preparation and application |
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Application publication date: 20130227 |