CN111214584B

CN111214584B - Traditional Chinese medicine composition for tonifying kidney and benefiting liver as well as preparation method and application thereof

Info

Publication number: CN111214584B
Application number: CN202010101817.3A
Authority: CN
Inventors: 刘景城; 张续
Original assignee: Beijing Gold Shuangyi Pharmaceutical Technology Development Co ltd
Current assignee: Beijing Gold Shuangyi Pharmaceutical Technology Development Co ltd
Priority date: 2020-02-19
Filing date: 2020-02-19
Publication date: 2022-02-22
Anticipated expiration: 2040-02-19
Also published as: CN111214584A

Abstract

The invention relates to a traditional Chinese medicine composition for tonifying kidney and liver, a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises 80-120 parts of astragalus mongholicus, 60-85 parts of wolfberry fruit, 60-85 parts of bighead atractylodes rhizome, 50-60 parts of angelica sinensis, 50-60 parts of semen cuscutae, 80-120 parts of glossy privet fruit, 90-110 parts of moutan bark, 40-55 parts of polygonum cuspidatum, 40-60 parts of divaricate saposhnikovia root and 100-120 parts of liquorice. Also discloses application of the pharmaceutical composition in preparing medicines for treating hematuria, proteinuria, hematuria proteinuria, simple nephrotic syndrome, nephritic nephrotic syndrome, purpura nephritis, spleen and kidney qi deficiency, liver and kidney yin deficiency, spleen and kidney deficiency, kidney qi deficiency, spleen and kidney deficiency and liver and kidney yin deficiency.

Description

Traditional Chinese medicine composition for tonifying kidney and benefiting liver as well as preparation method and application thereof

Technical Field

The invention relates to a Chinese medicinal composition, in particular to a Chinese medicinal composition for tonifying kidney and liver,

background

The preparation has the advantages of maintaining and consolidating the nephropathy treatment, tonifying qi and nourishing blood, enhancing physique, preventing and treating cold and reducing hematuria and proteinuria, has obvious curative effects of tonifying liver and kidney, and has wide application range compared with simple astragalus granules, stronger effects of tonifying liver and kidney compared with spleen-tonifying kidney granules, and has the effect of eliminating hematuria proteinuria.

Disclosure of Invention

[ BASE CHEMICAL PROBLEMS ] Astragalus membranaceus 100g, Lycium barbarum fruit 75g, Atractylodes macrocephala 75g, Angelica sinensis 50g, Cuscuta chinensis 50g, Ligustrum lucidum fruit 100g, moutan bark 100g, Polygonum cuspidatum 50g, Saposhnikovia divaricata 50g, and Glycyrrhiza uralensis 100 g.

The components which can be added and subtracted in the embodiment: rhizoma Polygonati Odorati, Alismatis rhizoma, Saviae Miltiorrhizae radix, Ecliptae herba, and radix Angelicae Dahuricae

Nephritis and various nephropathies, which are characterized by lusterless complexion, hypodynamia, anorexia and the like in clinical use, are caused by deficiency of spleen and kidney, deficiency of liver and kidney qi and blood, spleen governing transportation and transformation, spleen deficiency failing to transport, deficiency of the spleen, anorexia, kidney deficiency, waist soreness and hypodynamia, deficiency of qi and blood, lusterless complexion, deficiency of liver, spleen and kidney, and deficiency of water and dampness, can cause anemia and edema, and are used for strengthening spleen and tonifying kidney, tonifying qi and nourishing blood, and removing dampness and activating blood circulation. The method comprises the following steps: the astragalus and the medlar are monarch drugs, and the astragalus is sweet and warm, has the effects of tonifying spleen and kidney, supplementing qi and activating stagnancy, promoting the production of body fluid and blood and enhancing immunity; the medlar is sweet and neutral, and has the effects of tonifying liver and kidney, nourishing liver, improving eyesight, protecting liver, moistening lung, enhancing immunity and promoting hematopoiesis. Rhizoma atractylodis macrocephalae, angelica, semen cuscutae and glossy privet fruit are ministerial drugs. Wherein the bighead atractylodes rhizome has the functions of tonifying spleen and qi and enhancing the function of the astragalus, and the angelica has the functions of nourishing yin and blood and enhancing the functions of monarch drugs in nourishing yin and activating blood; dodder seed, ligustrum lucidum and assistant monarch drugs to nourish yin and tonify kidney, nourish liver and improve vision, resist bacteria and relieve cough, enhance immunity and tonify liver and kidney. Cortex moutan, rhizoma Polygoni Cuspidati, and radix Saposhnikoviae are used as adjuvant drugs, and have the effects of clearing away heat and toxic materials, promoting blood circulation, dispelling blood stasis, and eliminating dampness and heat, and are used together with radix Saposhnikoviae for relieving exterior syndrome, dispelling pathogenic wind, and preventing diseases; for blood stasis due to chronic disease, cortex moutan is selected to promote blood circulation to dissipate blood stasis, cool blood to stop bleeding, remove rash and cure carbuncle; ledebouriella root, radix Saposhnikoviae has the effects of expelling pathogenic wind, eliminating dampness and relieving pain, and has antipyretic, analgesic, antibacterial and anti-convulsion effects. Licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe. The traditional Chinese medicine composition has the effects of tonifying spleen and kidney, tonifying qi and nourishing blood, and promoting diuresis and blood circulation, and modern medicine believes that the traditional Chinese medicine composition can eliminate proteinuria, protect liver and kidney functions, enhance immunity, has wide broad-spectrum antibacterial, anticoagulant and antiallergic effects, and has the effects of resisting hormone and side effects of immunosuppressive drugs.

The functions and indications are as follows: invigorate spleen and kidney, replenish qi and nourish blood, induce diuresis to alleviate edema. Can be used for treating deficiency of spleen and kidney qi and blood, pale complexion, asthenia, anorexia, soreness of waist, edema, dysuresia, nephrotic syndrome, and nephritis.

Decocting the above ten medicines in water twice, the first time for 2 hours, and the second and third times for 1 hour respectively, mixing decoctions, filtering, concentrating the filtrate to obtain 1 part of soft extract with relative density of 1.30-1.35(50 deg.C), granulating with 1 part of soft extract, 2 parts of sucrose, 1 part of dextrin and appropriate amount of ethanol, drying, and making into 1000 g.

The above basic formulas are radix astragali, fructus Lycii, Atractylodis rhizoma, radix Angelicae sinensis, semen Cuscutae, fructus Ligustri Lucidi, cortex moutan, rhizoma Polygoni Cuspidati, radix Saposhnikoviae, and Glycyrrhrizae radix.

Radix Angelicae Dahuricae has effects of clearing away heat and toxic materials, eliminating dampness and stopping leukorrhagia

When mild edema is accompanied, Alismatis rhizoma can be added to promote diuresis and promote the actions of Huang Qi and Bai Zhu

When high blood coagulation is accompanied, salvia miltiorrhiza is added to strengthen the effects of dredging collaterals and promoting blood circulation to remove blood stasis.

Rhizoma Polygonati Odorati can be added for treating obesity, and has effects of moistening dryness, nourishing yin, lowering blood sugar, reducing blood lipid, and reducing hormone dosage.

Herba Ecliptae can be added for treating hematuria, and has effects in cooling blood, stopping bleeding, nourishing kidney and liver, enhancing immunity, and resisting mutation.

The invention provides a traditional Chinese medicine composition for tonifying kidney and benefiting liver, which comprises the following components in parts by weight:

the invention provides a traditional Chinese medicine composition for tonifying kidney and liver, which is prepared from the following raw materials in parts by weight:

the invention provides a traditional Chinese medicine composition for tonifying kidney and liver, which comprises the following components in parts by weight:

further, the above-mentioned component or raw material component is preferably

Or;

or

Or

Or

In the technical scheme of the invention, the traditional Chinese medicine composition is prepared by the following method: weighing the astragalus, the medlar, the bighead atractylodes rhizome, the angelica, the dodder, the glossy privet fruit, the tree peony bark, the giant knotweed rhizome, the divaricate saposhnikovia root and the liquorice according to the weight parts, adding water for decocting twice, 2 hours for the first time and 1 hour for each of the second time and the third time, combining the decoctions, filtering, and concentrating the filtrate to 1 part of thick paste with the relative density of 1.30-1.35 to obtain the traditional Chinese medicine.

Further, 1 part of cane sugar 2 parts, 1 part of dextrin and ethanol are prepared into particles and dried.

In another aspect, the invention provides a method for preparing a Chinese medicinal composition, which comprises the following steps: weighing the astragalus, the medlar, the bighead atractylodes rhizome, the angelica, the dodder, the glossy privet fruit, the tree peony bark, the giant knotweed rhizome, the divaricate saposhnikovia root and the liquorice according to the weight parts, adding water for decocting twice, 2 hours for the first time and 1 hour for each of the second time and the third time, combining the decoctions, filtering, and concentrating the filtrate to 1 part of thick paste with the relative density of 1.30-1.35.

In another aspect, the invention provides application of the traditional Chinese medicine composition in preparing medicines for treating hematuria, proteinuria, hematuria proteinuria, simplex nephrotic syndrome, nephritic nephrotic syndrome, purpura nephritis, spleen and kidney qi deficiency, liver and kidney yin deficiency, spleen and kidney deficiency, kidney qi deficiency, spleen and kidney deficiency and liver and kidney yin deficiency.

Advantageous effects

The pharmaceutical composition of the invention can invigorate the spleen and tonify the kidney, replenish qi and nourish blood, induce diuresis and reduce edema. Can be used for treating deficiency of spleen and kidney qi and blood, pale complexion, asthenia, anorexia, soreness of waist, edema, dysuresia, nephrotic syndrome, and nephritis. The preparation method is simple and has good effect.

Detailed Description

Example 1

Example 2

Decocting the above ten medicines in water twice, the first time for 2 hours, and the second and third times for 1 hour respectively, mixing decoctions, filtering, concentrating the filtrate to obtain 1 part of soft extract with relative density of 1.30-1.35(50) deg.C, granulating 1 part of soft extract, 2 parts of sucrose, 1 part of dextrin and appropriate amount of ethanol, drying, and making into 1000 g.

Example 3

Example 4

Example 5

EXAMPLE 6 clinical validation of sample treatment of example 1 in 100 cases of pediatric Kidney disease

Typing is carried out according to the clinical typing diagnosis standard revised by the national pediatric renal group in 2001, the national conference of traditional Chinese medicine and the classification standard of Chinese and western pediatric scientific diagnosis, and the selection standard of the cases of the invention is as follows: hematuria: it refers to simple hematuria, and does not include the phenomenon of walnut clamp; hematuria proteinuria: more than Pro + + in urine and more than 8-10/HP in hematuria; nephrotic syndrome is a national standard of unity, including simple and nephritic.

The test results are shown in the following table after 7 days of once daily administration of the preferred pharmaceutical formulation example 1 of the present invention to each group of patients.

The obvious effect is as follows:

1. the symptom index disappears or the symptom is reduced by more than 90 percent after treatment compared with before treatment;

2. urine test is normal or essentially normal: the content of Pro (-) and (+/-) RBCO-3/HP or below 3-6/HP is obviously reduced compared with the original content;

3. the blood biochemical and immune indexes are normal or better than those before treatment.

The good conversion is as follows:

1. the symptom index is improved by more than 50 percent and less than 90 percent better;

2. the urine test index is better, including Pro is less than or equal to 2+ RBC 6-10/HP;

3. the blood biochemical and immune indexes are better than the former indexes.

The invalidation is:

1. the symptom index is not changed or is improved by less than 50 percent compared with the symptom index before treatment;

2. the urine test index is not obviously improved or the medicine taking period is not repeated obviously, including that Pro is more than or equal to 3 percent and RBC is more than or equal to 10-15/HP in urine.

Effective includes significant effect and improvement.

TABLE 1 EXAMPLE 1 clinical Total efficacy of sample treatment of 100 cases of pediatric renal diseases

Research results show that the total effective rate of the traditional Chinese medicine composition for treating hematuria, hematuria proteinuria, simple nephrotic syndrome, nephritic nephrotic syndrome and purpura nephritis reaches over 95 percent, the significant efficiency exceeds 65 percent, and the traditional Chinese medicine composition has the best effect on the simple nephrotic syndrome and the significant efficiency reaches 88 percent.

Example 7 Observation of the above 100 cases of infantile kidney diseases by TCM diagnosis and treatment

According to the typing group of the traditional Chinese medicine, patients are divided into three types of spleen-kidney qi deficiency, liver-kidney yin deficiency and spleen-kidney deficiency, and the typing clinical application results of the three types of the traditional Chinese medicine are examined.

Wherein, the main symptoms of qi deficiency of spleen and kidney are frequent micturition, dribbling, lassitude, pale tongue, white fur and thready and weak pulse; the main symptoms of liver-kidney yin deficiency are soreness and weakness of waist and knees, hypochondriac pain, vertigo and tinnitus; the deficiency of both the spleen and kidney clinically manifests as the failure of the rectum to slip and collapse, the feeling of anus falling, dizziness, tinnitus, mental fatigue, short breath, soreness and weakness of the waist and knees, frequent micturition at night, loose stool, dry stool, difficult defecation and pale tongue. Deep and weak pulse.

Significant effect means that symptoms basically disappear or are relieved by more than 90 percent;

the improvement means that the symptoms are obviously relieved, and the relief is more than 50 percent and less than 90 percent.

Null means no significant relief of symptoms.

The experimental result shows that the total effective rate of the composition of the invention aiming at spleen and kidney qi deficiency, liver and kidney yin deficiency and spleen and kidney deficiency reaches more than 95%, and the significant efficiency exceeds 70%.

Example 8138 clinical symptom segmentation study of TCM typing cases

According to the classification of traditional Chinese medicine, patients are classified into three types of patients with kidney qi deficiency, spleen-kidney deficiency and liver-kidney yin deficiency, and the results of the three types of traditional Chinese medicine classification clinical application are examined. Mainly aims at the symptom to be evaluated, and takes the patient chief complaint as the judgment standard

The kidney qi deficiency refers to the clinical symptoms of both kidney deficiency syndrome and qi deficiency syndrome. The main symptoms are shortness of breath, spontaneous perspiration, lassitude, weakness, pale complexion, spermatorrhea, premature ejaculation, dribbling after urination, frequent and clear urination, soreness and weakness of waist and knees, hearing loss, cold limbs, thready and weak pulse and the like.

The clinical manifestations of deficiency of both spleen and kidney are the failure of the rectum to slip and the feeling of tenesmus of the anus, accompanied by dizziness, tinnitus, lassitude, frequent micturition at night, shortness of breath, soreness and weakness of the waist and knees, loose stool or dry stool difficult to discharge, and pale tongue. Deep and weak pulse.

The clinical manifestations of liver-kidney yin deficiency are soreness of the waist, hypochondriac pain, vertigo, tinnitus and spermatorrhea.

TABLE 3138 analysis of the sample of example 1 for the improvement rate of the pre-and post-treatment main clinical symptoms

The experimental result shows that the composition has little influence on the hair withering and yellow symptoms except the liver and kidney yin deficiency symptoms, and has great relief on other symptoms.

Claims

1. A traditional Chinese medicine composition for tonifying kidney and liver comprises the following components in parts by weight:

the traditional Chinese medicine composition is prepared by the following method: weighing the astragalus, the medlar, the bighead atractylodes rhizome, the angelica, the dodder, the glossy privet fruit, the tree peony bark, the giant knotweed rhizome, the divaricate saposhnikovia root and the liquorice according to the weight parts, adding water for decocting twice, 2 hours for the first time and 1 hour for each of the second time and the third time, combining the decoctions, filtering, and concentrating the filtrate to 1 part of thick paste with the relative density of 1.30-1.35 to obtain the traditional Chinese medicine.

2. The Chinese medicinal composition according to claim 1, wherein the preparation method further comprises granulating the thick paste 1 part, sucrose 2 parts, dextrin 1 part and ethanol, and drying.

3. The method for preparing the Chinese medicinal composition of claim 1, which is prepared by the following steps: weighing radix astragali, fructus Lycii, Atractylodis rhizoma, radix Angelicae sinensis, semen Cuscutae, fructus Ligustri Lucidi, cortex moutan, rhizoma Polygoni Cuspidati, radix Saposhnikoviae, and Glycyrrhrizae radix, decocting in water twice (2 hr for the first time and 1 hr for the second and third times respectively), mixing decoctions, filtering, and concentrating the filtrate to obtain 1 part of soft extract with relative density of 1.30-1.35.

4. The preparation method according to claim 3, further comprising granulating the thick paste 1 part, sucrose 2 parts, dextrin 1 part and ethanol, and drying.

5. A medicament which takes the traditional Chinese medicine composition as claimed in claim 1 as an active ingredient and is an oral preparation.

6. The medicament of claim 5, wherein the oral preparation is selected from the group consisting of tablets, granules, decoction, syrup, tincture, capsules, and oral liquid.

7. Use of the Chinese medicinal composition of claim 1 or the medicament of claim 5 or 6 for the preparation of a medicament for treating hematuria, hematuria proteinuria, simple nephrotic syndrome, nephritic nephrotic syndrome, purpura nephritis.

8. Use of the Chinese medicinal composition of claim 1 or the medicament of claim 5 or 6 in the preparation of a medicament for treating deficiency of spleen and kidney qi, deficiency of liver and kidney yin, deficiency of both spleen and kidney, and deficiency of kidney qi.