CN1055847C

CN1055847C - Medicine for curing deficiency of liver and kidney

Info

Publication number: CN1055847C
Application number: CN95112054A
Authority: CN
Inventors: 于圣德
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-10-13
Filing date: 1995-10-13
Publication date: 2000-08-30
Anticipated expiration: 2015-10-13
Also published as: CN1147941A

Abstract

The present invention relates to oral medicinal liquid of a Chinese patent medicine for curing the deficiency of the liver and kidney, which is prepared from hydrolysate of oyster and abalone shell, water decocted liquid of Chinese wolfberry fruit, Chinese dodder seed and astragalus root, and stevioside. The oral medicinal liquid is from 4.0 to 4.5 mg/ml, the pH value is from 3.0 to 5.0, the relative density is from 1.02 to 1.05, and the oral medicinal liquid has a little bit fragrance and a little bitter taste. Immunology and pharmacodynamic tests prove that the medicine can improve immune functions and anti-stress ability and has the good functions for nourishing blood, adding essence, strengthening bone, tonifying the kidney, benefiting qi and stabilizing the center. In hundreds of clinical treatment cases, the oral medicinal liquid has excellence rate31%, effective rate 63% and total effective rate 95%, and the total effective rate of the oral medicinal liquid is obviously superior to that of control groups of similar Yin nourishing and kidney reinforcing medicines.

Description

Treatment is because of morbific medicine of caused by liver and kidney deficiency and method for making thereof

What the present invention relates to is Chinese patent medicine and method for making thereof, and particularly treatment is because the Chinese patent medicine and the method for making thereof of the disease that caused by liver and kidney deficiency causes.

Caused by liver and kidney deficiency is the modal clinically frequently-occurring disease that is detrimental to health, its symptom for have a dizzy spell, poor or weak eyesight tinnitus, little sleep disturbed by dreams is forgetful, deficiency-heat is fidgety, soreness of the waist and knees or pain, spontaneous sweating, dry mouth and throat, hyposexuality, man pass out semen premature ejaculation or woman's infrequent menstruation, body is weak or become thin etc.See the sufferer of modern medical diagnosis, as cardiovascular and cerebrovascular disease, type ii diabetes, neurosis, chronic hepatitis, nephritis, the tumprigenicity neurasthenia, menoxenia, anemia and senile osteoporosis, autonomic nervous dysfunction etc. are also because of due to the caused by liver and kidney deficiency.The medicine of kidney invigorating and YANG supporting, health product are various in style in the market, yet a large amount of clinical medicine statistics shows among numerous patients of suffering from a deficiency of the kidney that deficiency of kidney-YIN, hyperactivity of fire caused by deficiency of YIN person are in the majority.This type of patient such as indiscriminate high kidney-replenishing, Xing Yang get angry, then scorching impairment of body fluid, and kidney yin is more lost in of a specified duration certainly will causing, kidney yang final result more.The experience that traditional Chinese medical science long-term clinical practice is summed up is out thought: blood stored in the liver, kidney storing essence, and the essence and blood alternate, The liver and the kidney have a common source, essence and blood sharing the same origin; " arrogate to oneself YANG invigorating person must from treating YANG within YIN ", deficiency of kidney yin can involve liver-yin, the disease that the Liver and kidney tool loses tool void finally occurs.Modern medicine study thinks that the deficiency syndrome of traditional Chinese medical science meaning and calmodulin, CaM Cam have direct relation, and is more in close relations with cyclic nucleotide cAmp, cGmp, and its activity can cause imbalance of YIN and YANG and " all kinds of diseases and ailments are living " with the imbalance of concentration ratio.There is the organic compound of water solublity ion state calcium alive to have the effect of class calmodulin, CaM activation factor among the compound recipe L-OTG that Chinese patent (application number is 93111079.3) proposes, cAMP, the effect of cGMP medium, the anti-cancer active matter effect, stride the film ionization, pharmaceutical carrier effect and inducement interferon and short interleukin II effect.

The objective of the invention is provides a kind of nourishing liver and kidney according to theory of Chinese medical science and modern medical theory and practice, particularly the hepatic and renal YIN deficiency is had the Chinese patent medicine and the manufacturing process thereof of significant curative effect.

The present invention utilizes active ion attitude calcium organicly strides film ionization and pharmaceutical carrier effect the medicine of tonifying liver deficiency of kidney-YIN is imported human body, more brings into play synergism, reaches its hepatic and renal YIN deficiency of effective benefit and loses function.

Medicine of the present invention is to be made by the hydrolysate of Concha Ostreae, Concha Haliotidis and Fructus Lycii, Semen Cuscutae, the water extract of the Radix Astragali, stevioside.Making the used composition of raw materials of 100L oral liquid is:

Concha Ostreae 20～30kg

Fructus Lycii 10～20kg

Semen Cuscutae 10～15kg

The Radix Astragali 10～20kg

Concha Haliotidis 10～15kg

Its manufacture method of stevioside 0.5～1.0kg is:

(1) Concha Ostreae, Concha Haliotidis clean, dry, be crushed to fineness by 80 mesh sieve holes, add concentrated hydrochloric acid boil molten, with the CO that produces ₂Release most back at 110 ℃ of following pressurized hydrolysis 14～16h, the cooling pressure release is 3～4 with alkali liquor with the PH levelling of solution, with the proper amount of active carbon decolouring, filters filtrate for later use;

(2) Fructus Lycii, Semen Cuscutae, the Radix Astragali are steeped 2h with 8 times of water loggings, decoct 2 times, each 40min merges 2 times decoction liquor, and being concentrated into relative density is 1.02～1.03 (80 ℃), and cooling back cold preservation 24h filters;

(3) two kinds of filtrates are merged, add stevioside, homogenizing leaves standstill, and filters, and the filtrate thin up forms through fill, sterilization, capping to 100L.

This oral liquid is a brown yellow solution, feeble QI perfume (or spice), and mildly bitter flavor, relative density is 1.02～1.05, and PH is 3.0～5.0, and wherein calcic is 4.0～5.0mg/mI.

Medicine of the present invention through the many indexs of laboratory animal, systematically carry out immunology, the test of pesticide effectiveness proves: (1) improves non-specific and specific immune function, strengthens by the cell-mediated cellular immunization of Tc with by the cell-mediated humoral immunization of Bc and transfer IgA, IgM, IgG, C ₃Deng; (2) can improve animal endurance, heat-resisting ability anti-stress ability and improve body, health invigorating; (3) have good YIN nourishing blood, add marrow, fill brains, hard muscles and bones; Tonify Qi of the kidney, the sexual function improvement effect; (4) to preventing oxygen toxicity, Antiradiation injury and tumor, aspects such as inflammation, old and feeble and fatigue play an important role; (5) can strengthen the learning and memory function, have the stable effect of maincenter.Oral liquid has also been carried out acute toxicity and long term toxicity test to be proved without any side effects.Medicine of the present invention is also at the clinical observation of curative effect of having made treatment hepatic and renal YIN deficiency disease 100 examples and matched group 60 examples, its obvious effective rate is 31%, effective percentage is 63%, total effective rate is 95%, (obvious effective rate is 18.33% with the matched group of taking similar enriching yin and nourishing kidney medicine, effective percentage is 58.33, and aggregate efficiency is 76.66%) contrast has a notable difference (P＜0.05).

The present invention combines with Traditional Chinese medical theory and modern medicine technology, medication is concise, compatibility is reasonable, implied meaning is clear and definite, method for making is simple, in the property of medicine and the makings equilibrium, tonify without causing stagnation, invigorating middle warmer has diffusing, reach mend the day after tomorrow and help congenital, add marrow, fill brains, nourishing YIN blood, the effect that bone and muscle strengthening, QI invigorating are set upright.The particularly effect of solubility active ion attitude calcium, the medicine spy is penetrated matter between cell tissue, blood-brain barrier and enter in the cerebrospinal fluid, cause that directly enzyme activities such as sugared source, fat, protein change, and make cell tissue produce multiple metabolism regulate and play enhance metabolism with stable in environment have important effect.This is that forefathers' technology fails to reach.

Example

Lucky oral liquid manufacturing difficult to understand.

Used primary raw material is:

Concha Ostreae 20kg

Fructus Lycii 10kg

Semen Cuscutae 10kg

Radix Astragali 10kg

Concha Haliotidis 10kg

Stevioside 0.5 method for making is for delaying hydrochloric acid and continuous stirring that adding concentration is 12mol/L through cleaning, be dried to the Concha Ostreae, the Concha Haliotidis that crush, slow add thermosol and boil, constantly disengage carbon dioxide, after gas is released to the greatest extent, solution is inserted in the autoclave pressure, at 110 ℃ of following pressurized hydrolysis 14h, cooling decompression back is 3.5 with 35～40% liquid caustic soda levelling PH, adds the 5kg activated carbon decolorizing, and it is standby to filter the about 8L of rear filtrate; Get Fructus Lycii, Semen Cuscutae, the Radix Astragali and add 240kg water logging bubble 2h, decoct 40min, filter filtering residue reuse 240kg water and fry in shallow oil again once, filter once more behind the 40min, merge the secondary decocting liquid, being concentrated into relative density is 1.02～1.03 (80 ℃), cold preservation 24h, filter rear filtrate and Concha Ostreae, the merging of Concha Haliotidis hydrolysis filtrate, add stevioside, homogenizing leaves standstill after-filtration, filtrate adds water to 100L, and bottling, sterilization, capping form oral liquid.Its feeble QI perfume (or spice); Relative density is 1.03, and PH is 4.15, and calcium content is 4.53mg/ml.

Sick effectively example (%) invalid example (%) total effective rate cardiovascular and cerebrovascular disease 51 16 (31.37) 32 (62.75) 3 (5.88) 94.12% neurasthenia 20 5 (25) 14 (70) 1 (5) 95% diabetes 93 (33.33) 5 (55.56) 1 (11.11) 88.89% neurasthenia sexualises 33 (100) 100% ephrosis 73 (42.86) 3 (42.86) 1 (14.29) 85.71% respiratory diseases 52 (40) 2 (40) 1 (20) 80% hepatobiliary diseases 22 (100) 100% climacteric metancholias 11 plant N dysfunctions 11 anaemias 11 of routine digital display effect example (%) of planting of the different sick curative effect tool following tables of planting of (table one) lucky oral liquid clinical treatment difficult to understand

Forgetful 100 3.27 1.11 17.48＜0.05 soreness and weakness of waist and knees pain of dizzy 100 3.83 1.37 29.4＜0.05 insomnia and dreamful sleep of average integral t p dizziness and tinnitus 98 3.31 1.31 5.53＜0.05 spontaneous perspiration, night sweat 65 2.34 0.63 8.12＜0.05 impotence and seminal emission premature ejaculation 27 2.78 0.85 2.60＜0.05 woman were through few weak 58 2.84 1.23 15.65＜0.05 appetite energy 73 2.71 0.70 18.97＜0.05 of lower dry mouth and throat 92 3.14 0.95 11.76＜0.05 body of being with after the clinical front average integral of curative effect table symptom example number treatment that caused by liver and kidney deficiency card symptom integral is changed of (table two) lucky oral liquid difficult to understand was treated

Claims

1, a kind of treatment is to produce with following raw material and through following method because the medicine of the disease that caused by liver and kidney deficiency causes is characterized in that a kind of pale brown color oral liquid:

Concha Ostreae 20～30kg

Fructus Lycii 10～20kg

Semen Cuscutae 10～15kg

The Radix Astragali 10～20kg

Concha Haliotidis 10～15kg

Stevioside 0.5～1.0kg

(1) will clean, exsiccant Concha Ostreae, Concha Haliotidis pulverize, and boils dissolving CO to the greatest extent with concentrated hydrochloric acid ₂At 110 ℃ of following pressurized hydrolysis 14～16h, it is 3～4 that PH is transferred with alkali liquor in cooling decompression back, and activated carbon decolorizing filters filtrate for later use;

(2) get Fructus Lycii, Semen Cuscutae, the Radix Astragali and add 8 times of water loggings bubble 2h, decocts 2 times, 40min merges 2 times decoction liquor at every turn, and being concentrated into relative density under 80 ℃ is 1.02～1.03, and cold preservation 24h filters standby;

(3) two filtrates merge, and add stevioside, and homogenizing filters, and the filtrate thin up is to 100L, fill, and sterilization forms; Medicine calcic 4.0～5.0kg/ml, PH are 3.0～5.0, and relative density is 1.02～1.05.