CN105596551A - Traditional Chinese medicine composition having asthenopia relieving function and preparation method thereof - Google Patents

Abstract

A traditional Chinese medicine composition having an asthenopia relieving function is prepared from, by weight, 200-300 parts of astragali radix, 200-300 parts of periostracum cicada, 200-300 parts of radix angelica sinensis, 200-400 parts of the fruits of Chinese wolfberry, 50-100 parts of cassia seeds, 50-100 parts of chrysanthemum flowers, 50-100 parts of red jujubes and 50-100 parts of licorice roots. A preparation method comprises the steps that the medicinal raw materials are put into a container, 8-10 times by weight of water is added for soaking for 2-3 hours, and heating decoction is performed for 1.5-2 hours; then 8-10 times by weight of water is added into decoction dregs to perform heating decoction is performed for 1.5-2 hours, and filtration is performed; the filtrates are mixed to obtain supernate; the supernate is prepared into an oral solution by adopting a conventional process or is concentrated, the concentrated supernate is fed into a spray dryer, and mist spraying is performed to obtain dry powder; the spray-dried powder is prepared into a conventional solid oral preparation by adopting a conventional pharmaceutical method. The traditional Chinese medicine composition has the improvement effects on eye distension, eye pain, photophobia, blurred vision, eye dryness and the like.

Description

A kind of Chinese medicine composition and preparation method with asthenopia releasing function

Technical field

The present invention relates to Chinese medicine composition, be specifically related to a kind of taking can for the Chinese herbal medicine of health food as raw material makeThe Chinese medicine composition with asthenopia releasing function, the invention still further relates to the Chinese medicine composition with asthenopia releasing functionPreparation method.

Background technology

Eyes, i.e. order. " internal diameter " is called " shrewdness ", " gate of vitality ". Order is the organ of specially taking charge of vision, and " Plain Questions arteries and veins is wanted essenceMicro-opinion " say: " husband a knowing card, so look all things on earth, Bie Baihei, examines short length. " its organs of vision that are human body, major function is for observingExtraneous things.

Visual fatigue claims again kopiopia, is taking the subjective symptoms of patient's eye as basis, eye or whole body apparatus factors and spiritThe syndrome that (psychology) factor is interweaved, and dependent illness in eye, thereby be usually called as kopiopia syndrome. Aobvious according to investigationsShow approximately have 7% to 8% crowd all to have visual fatigue phenomenon. People in the face of screens such as computers, TV, mobile phone, meetingMore focus one's attention on than usual, reduce frequency of wink, cause excessively using eye, thereby cause ciliary muscle to accelerate distortion, eye fleshMeat group cannot be loosened, so eyes are especially easily tired, and then occur that eyes are ached, eye-blurred, appearance be dry and astringent, tiredLabor, furious, gargalesthesia, be even also accompanied by visual impairment.

Theory of traditional Chinese medical science is thought " liver opening at eye ", " blood stored in the liver ", " order is subject to blood and can looks ", whether normal visual acuity to be, depends onThe catharsis of irritability and the honor of liver blood are supported. Deficiency of liver-blood, two xerophtalmias, order is secretly not clear, blurring of vision; Liver-fire flaming, hot eyesSwell and ache. Miraculous Pivot claims " the essence of five ZANG-organs and six FU-organs gas is noted in order on all and essence for it ", therefore eyes and the five internal organs also have close contacting." blood stored in the liver ", liver is being stored very abundant blood. If irritability catharsis, liver blood is full, and lifting is suitable, come in and go out while having joint, and liverQi and blood moisten in order in a steady stream, order can normal shrewdness be looked thing. Liver has pathology often to involve in order, and modern medicine is thought, acute and chronic liverThe hepatic diseases such as inflammation, cirrhosis, liver cancer all can cause ophthalmic complications.

From medical angle, computer causes that VI reason has two kinds: one, eye fatigue. When no matter we are longBetween see that computer still reads a book, eyes all can be tired, result is that ciliary muscle continues to shrink, and causes myopia; Two, be that computer blue light is to eyeEnd retina cell's stimulation. This stimulation itself can cause the apoptosis of cellula visualis, causes visual impairment, and this stimulationMake eyes more easily feel tired. Therefore use for a long time computer, see that TV, reading etc. all can cause excess eye-using, look for a long time easilyCause deficiency of liver-blood.

At present, for the remission method of eye fatigue, of all kinds, but more or less all exist effective not highly, effect is notThe problem such as stable, the patent No. is that CN200610104761.7, denomination of invention are a kind of for eye health, alleviating asthenopiaChinese medicine preparation is that this product is to rest gods with Chinese yam, Poria cocos, cultivated land, Fructus Corni, rhizoma alismatis, matrimony vine, chrysanthemum, when being classified as raw materialOrder, clear liver and improve vision, the various drug regimens with improving eyesight effect such as removing heat to brighten vision, yin-nourishing improving eyesight, nourishing blood for improving eyesight together, prescriptionComparatively complicated, curative effect is comparatively extensive. The patent No. is that CN201110207938.7, denomination of invention are that one has health care and treatmentThe eye protection Chinese medicinal composition of effect is with ginkgo biloba p.e, ginseng, Radix Angelicae Sinensis, pipewort, the Radix Astragali, honeysuckle, cicada slough, matrimony vineSon, peppermint, santal are raw material, have qi and activate blood circulation dredging collateral, effect of clearing heat and detoxicating improving eyesight; But prescription adopts ginseng, ginkgo leafExtract etc., expensive, and should not take by child on long-term.

Summary of the invention

The technical problem to be solved in the present invention is to provide that a kind of prescription is simple, reasonable price, be applicable to any age bracketThe Chinese medicine composition of what colony took have asthenopia releasing function; The invention still further relates to the Chinese medicine with asthenopia releasing functionThe preparation method of composition.

For this reason, the present invention adopts following technical scheme: a kind of Chinese medicine composition with asthenopia releasing function, its featureBe to be made by the bulk drug of following weight proportioning: 200 ~ 300 parts of the Radixs Astragali, 200 ~ 300 parts of cicada sloughs, 200 ~ 300 parts of Radix Angelicae Sinensis, matrimony vine50 ~ 100 parts of 200 ~ 400 parts of sons, 50 ~ 100 parts of cassia seeds, 50 ~ 100 parts of chrysanthemums, red date and 50 ~ 100 parts, Radix Glycyrrhizae.

Its preferred weight proportion is: 200 parts of the Radixs Astragali, 250 parts of cicada sloughs, 200 parts of Radix Angelicae Sinensis, 400 parts of the fruits of Chinese wolfberry, cassia seed100 parts of 100 parts, 50 parts of chrysanthemums, red date and 50 parts, Radix Glycyrrhizae.

A kind of preparation method of the Chinese medicine composition with asthenopia releasing function; Step comprises:

(1) according to 200 ~ 300 parts of the Radixs Astragali, 200 ~ 300 parts of cicada sloughs, 200 ~ 300 parts of Radix Angelicae Sinensis, 200 ~ 400 parts of the fruits of Chinese wolfberry, cassia seed 50The weight portion proportioning of 50 ~ 100 parts of ~ 100 parts, 50 ~ 100 parts of chrysanthemums, red date and 50 ~ 100 parts, Radix Glycyrrhizae, weighting raw materials;

(2) step (1) bulk drug is entered to container, add 8～10 times of weight parts waters of bulk drug and soak 2～3 hours, heating decocts 1.5～2 hours, decoction liquor was filtered to obtain the first filtrate; The dregs of a decoction add 8～10 times of weight parts waters again, and heating decocts 1.5～2 hours, decoctLiquid filters to obtain the second filtrate; Merge the first filtrate and the second filtrate, obtain supernatant;

(3) by supernatant routinely technique be prepared into oral liquid; Or,

(4) be 1.04～1.07 o'clock by supernatant concentration to relative density, enter spray dryer, 170～185 DEG C of EATs,85～90 DEG C of leaving air temps, charging rate 250～350ml/min, obtains spray dried powder;

(5) by spray dried powder according to conventional pharmaceutical methods, add pharmaceutically acceptable auxiliary material or complementary composition, makeSaid conventional solid orally ingestible in acceptable, pharmacy, comprises granule or tablet or capsule clinically.

The present invention has tonifying liver blood, protects liver, effect of improving eyesight, A distinction should be made between what is primary and what is secondary in side, complements each other. Also tool of contained compositionThere are good nutritive value and health care, can harmonizing emotions, the pressure of releiving. Wherein, the Radix Astragali can promote hematopoiesis, and control is because of spokeThe number of nucleated cells of penetrating and cause reduces; The hepatic lesion that can cause some factor again has rise effect, can protect liver, anti-tiredLabor; Radix Angelicae Sinensis Compatibility with Radix Astragali, tonifying Qi is enriched blood, blood of gas promoting circulation of blood promotes liver blood circulation, thus on moisten in order, nourish Yin Run eyeball;The two had both strengthened amphiblestroid nutrition and cytoactive 5 with cicada slough, fundamentally enriched blood again, invigorated blood circulation, promoting circulation of blood, alleviated liver bloodThe diseases such as that not enough, liver-fire flaming causes is dry and astringent, order dark, swell and ache. The fruit of Chinese wolfberry, chrysanthemum, cassia seed filling liver kidney and improving eyesight. Several persons 5With, complement each other, treat both principal and secondary aspect of disease, thereby alleviate and improve alleviating asthenopia symptom.

The pharmacological function of bulk drug of the present invention is as follows:

(1) Radix Astragali: for the root of legume astragalus mongolicus or Astragalus membranacus, there is invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, soreEffect of myogenic. The pharmacological action relevant to Radix Astragali effect is enhanced machine body immunity function, strengthens hematopoiesis function, improves material generationThank, the anti-effect such as stress, delay senility; Also there is cardiac stimulant, regulate blood pressure, antiviral property myocarditis, protect the liver, the work such as antiulcerWith.

(2) cicada slough: be the shell after the black grasshopper emergence of cicada. Good Gu is said: cicada slough removes screen film, gets it and sloughs off justice also. Cicada propertySlough off and move back screen. Be mainly used in that hot eyes is swollen, pterygium. Hot eyes, ocular that these product cause wind-heat, and the raw screen film of order after measles,There is removing nebula effect. Pharmacological research shows, it can strengthen amphiblestroid nutrition and cellular activity, thereby alleviates computer blue light pairRetina cell's stimulation, reduces the damage of cellula visualis, maintains normal vision function.

(3) Radix Angelicae Sinensis: the root with umbelliferae angelica is used as medicine, taste is sweet, pungent, bitter, warm in nature, can enrich blood and invigorate blood circulation, and relaxes bowel.Essentials of Matea Medica is called it: " deficiency of blood can be mended, and blood depletion can be moistened ", to insufficiency of generating and transforming QI and blood, or QI-blood circulation is slow and deficiency of blood intestines are dryConstipation person, informal dress effect is good. Clinical and experiment showed, that this product has anti-anaemia, antivitamin E to lack and calm, analgesia, reducing blood lipid etc.Effect, also can increase coronary blood flow.

(4) fruit of Chinese wolfberry: be the dry mature fruit of matrimony vine of solanaceae plant. The sweet property of taste is flat, returns liver, kidney channel. It has nourishingLiver kidney, beneficial intensive culture blood, the improving eyesight screen that disappears, the effect moistening the lung and relieve the cough. Be used for the atrophic debility of bones of suffering from a deficiency of the kidney, soreness of waist and knee joint, dizzy tinnitus, blurred vision is notBright, the sallow grade of deficiency of blood disease. Chinese composition table of foods according to up-to-date publication is recorded, and in matrimony vine, carotene carotene content is significantly higher than fruitVegetables, contain abundant vitamin A, Aneurine, B2, C, and calcium, iron, also contain the one-tenth such as vitamin E, vitamin D, phosphatide and seleniumPoint. The essential nutrition of healthy eye; Its carrotene containing can change vitamin A in human body, and vitamin A can promoteIn retina, the synthetic or regeneration of visual purple, maintains twenty-twenty vision.

(5) cassia seed: be the dry mature seed of legume Cassia tora or little Cassia tora, its nature and flavor are sweet, bitter, salty, be slightly cold, and returnLiver, large intestine channel, have the effect of removing heat to brighten vision, sharp water defaecation. Cassia seed has step-down, adjusts fat, protects the liver, improving eyesight, immunologic functionThe multiple pharmacological effect such as adjusting, cure mainly the puckery pain of hot eyes, the many tear of photophobia, dizzy, the difficult urination of having a headache, habitual constipation etc. ClinicalExperiment showed, that drinking cassia-tora tea can clear liver and improve vision, prevent eye-blurred, hypotensive, reducing blood lipid, minimizing cholesterol etc., forPrevent and treat coronary heart disease, hypertension has good curative effect; And cassia seed is rich in vitamin A and zinc, can prevents and treats yctalopia and keep awayExempt from zinc deficiency in children. Cassia seed can activate the function of lactic dehydrogenase in ocular tissue (LDH) and play function of improving eyesight; In chrysanthemum, containAbundant vitamin A (retinol), it can maintain normal vision function, is the important substance of safeguarding eye health; In Radix Angelicae Sinensis, containSome polysaccharide energy hematopoietic stimulation versatile stem cells, proliferation of hematopoietic progenitors, differentiation, have the effect that promotes hematopoiesis, makes bloodFull, above moisten and nourish and order, play function of improving eyesight; In clearing liver and improving vision, the nourishing the liver of slightly holding concurrently, compatibility Radix Angelicae Sinensis, matrimony vine, can treat liver-yinThe ophthalmalgia that deficiency causes; Red date is rich in abundant vitamin C, has the merit of benefiting qi and nourishing blood, nourishing blood and tranquilization, soothing liver-qi stagnationEffect.

(6) chrysanthemum: be the dry capitulum of feverfew chrysanthemum, nature and flavor sweetness and bitterness, cool, has wind and heat dispersing, improving eyesight, removing toxic substancesEffect, cure mainly headache, dizzy, hot eyes, ambition dysphoria with smothery sensation, sore, serious case of furuncle. Modern pharmacological research shows, chrysanthemum has treatment hatWorry, reduce blood pressure, prevent high fat of blood, antibacterial, antiviral, anti-inflammatory, the anti-ageing multiple pharmacologically active of waiting for a long time; Chrysanthemum can reduce cardiac muscleThe scope of infarct and degree, improve the blood supply of the important organs such as heart kidney.

(7) red date: be the ripening fruits of Rhamnaceae plant jujube, sweet, warm; Tonifying middle-Jiao and Qi, nourishing blood and tranquilization.

(8) Radix Glycyrrhizae: be the root and rhizome of glycyrrhizic legume, glycyrrhiza inflate bat or glycyrrhiza glabra, " book on Chinese herbal medicine is just ": " taste is extremely sweet,The property that must neutralize, has the merit of adjusting benefit, therefore its poison of the solution that poison obtains, just medicine obtains its property of sum ... help ginseng stilbene to become the merit of the deficiency of vital energy. "

The present invention is by traditional Chinese medical science compatibility theory, with reference to modern medicines achievement in research, screens through long-felt the prescription letter drawingSingle, the Chinese medicine composition of a kind of alleviating asthenopia of instant effect, proves all to have definite clear through modern medicine and pharmacological researchThe efficacy effect of liver, tonifying liver blood, alleviating asthenopia. The effect that the fruit of Chinese wolfberry has protection liver, reduces blood sugar, delays senility; CertainlyPine torch has to protect the liver adjusts fat effect, and step-down intensity and the duration of its contained anthraquinone glycoside are better than compound reserpine; Chrysanthemum, redJujube or medicine food dual purpose plant, have anti-ageing, oxidation-resisting health-care effect. Each amounts of components has fine in described scopeCurative effect and have no side effect. The all medicine actings in conjunction of the present invention, have root active, and long-term low dose is taken, and can improve eyeball and look thingState, eliminates long-term use computer, sees the excess eye-using that TV, reading etc. cause, the symptoms such as deficiency of liver-blood. Effect test cardBright: this composition is improved effect for diseases such as experimenter's swollen, the ophthalmodynia of eye, photophobia, blurred vision and eye are dry and astringent; Experimenter shouldReach 96.52% by the improvement rate to eye symptom after month.

The actual record of efficacy test of the present invention, toxicology and observation on Clinical Application below.

1. efficiency index evaluation

The selection of 1.1 study subjects

From the test personnel of voluntary participation registration, select 25 ± 2 years old age, long-term with eye, eyesight fatiguability person is as gone out to lose faceBitterly, swollen, the blurred vision of eye, scorching hot red pain, dry and astringent photophobia, eyes are ached etc.; Experimenter's 150 examples, men and women half and half.

1.2 experimental design and grouping

Sample prescription 1: Radix Astragali 200g, cicada slough 250g, Radix Angelicae Sinensis 200g, fruit of Chinese wolfberry 400g, cassia seed 100g, chrysanthemum 50g, red date 100g,Radix Glycyrrhizae 50g;

Sample prescription 2: a kind of eye protection Chinese medicinal composition (CN201110207938.7) with health care and therapeutic efficiency is carried with ginkgo leafGet thing 50g, ginseng 70g, Radix Angelicae Sinensis 80g, pipewort 100g, Radix Astragali 100g, honeysuckle 100g, cicada slough 50g, matrimony vine 50g, peppermint100g, santal 80g, Radix Glycyrrhizae 60g composition.

Adopt two kinds of control design between self and group, according to symptom and eyesight situation, consider simultaneously sex, age etc. because ofElement, is divided into test group and control group by random double-blind method, every group of number 50 people.

1.3 test method

Test group is by recommend method and recommend consumption to take tested material, every day 3 times, each 4 (being equivalent to crude drug 5.4g); RightTake placebo according to group, the same test group of usage and consumption, continuously drug administration 30d.

1.4 observation index criterion

Observation index is safety indexes and efficiency index, each mensuration once when indices and test-meal start and finish. DiseaseShape improves: ophthalmodynia, swollen, the photophobia of eye, blurred vision, the dry and astringent arbitrary symptom of eye are improved 1 point and one point and be above improvement, 5 kinds of diseasesThe arbitrary improvement of shape and other symptoms judge symptom improvement without worsening; Effectively, before and after symptom improvement and duration of photopic vision, differ >=0.1, and comparing difference has statistical significance by statistics; Invalidly do not reach effective standard.

1.5 result of the test

Ordinary circumstance comparison before (1) two group of test-meal

Before two groups of test-meals, the indices difference such as age, sex, duration of photopic vision, left and right far visual acuity, symptom is without statisticsMeaning (P > 0.05), tool comparativity.

(2) efficiency index

Before and after test, eye cardinal symptom improvement situation is in table 1, and visual fatigue experimenter takes after the prescription of alleviating asthenopia, eyeSwollen, ophthalmodynia, photophobia, blurred vision, the dry and astringent improvement rate of eye are significantly higher than control group (P < 0.05), and test group eye of the present invention changesKind rate reaches 96.52%; Before and after test, duration of photopic vision changes relatively in table 2, and test group eyes duration of photopic vision of the present invention is averageImprove 24.15%, and statistical procedures difference there is conspicuousness; Before and after test, distant vision is relatively in table 3, and test group of the present invention is twoEye distant vision improves 0.17 ± 0.07%, and learning by statistics processing difference has conspicuousness (P < 0.05); The successful of sample prescription 1 is excellentIn sample prescription 2; From above-mentioned three effect index results, prescription of the present invention has the effect of effective alleviating asthenopia.

Can find out from whole test, the asthenopic Chinese medicine composition of improvement provided by the invention and the patent No. areSample and blank that a kind of eye protection Chinese medicinal composition with health care and therapeutic efficiency of CN201110207938.7 is madeCompare, the visual fatigue that all improves significantly, alleviates the malaise symptoms such as swollen, the ophthalmodynia of eye, photophobia, blurred vision, eye be dry and astringent. But thisInvent the aspects such as, blurred vision swollen at reduction of patient eye, eye are dry and astringent, curative effect is obviously better than contrasting patent, is alleviating and is improving and suffer fromPerson's ophthalmodynia, photophobia aspect curative effect are slightly weaker. The present composition is longer than tonifying liver blood, heat-clearing attenuation, mends to settle accounts and closes, and alleviation is looked tiredLabor; The patent No. is that the composition of CN201110207938.7 is longer than qi and activate blood circulation, the improving eyesight of heat-clearing attenuation.

2. toxicologic study

2.1 acute toxicity test conclusions

Within the observation period, mouse activity, feed, behavior etc. are all normal, without significantly poisoning symptom or bad reaction, dead without mouseDie. The main organs such as dissection the visual inspection heart, liver, spleen, lung, kidney show no obvious abnormalities change. Give animal subject maximum agentAfter amount, without animal dead, show that it is without acute toxicity.

2.2 safety testing evaluations

After test, before experimenter's routine blood test, routine urinalysis, hepatic and renal function and Electrocardioscopy and experiment, compare there was no significant difference,All no abnormal.

3. observation on Clinical Application

Medicine of the present invention is prepared into conventional oral formulations as clinical practice formulation, and its oral liquid instructions of taking is: one day 3Inferior, one time 1 (20ml).

The typical case of clinical trial:

(1) patient man, 22 years old, owing to often playing computer game, therefore in the face of computer screen is felt hot eyes often, the disease such as swell and ache, shed tearsShape, after taking according to the method described above medicine of the present invention month, transference cures such as hot eyes and look thing Clear and Bright, without sense of discomfort.

(2) patient female, 49 years old, certain engineer of building constructor, normal sense blurring of vision during working, eyeball are dry and astringent, photophobia etc.Sense of discomfort, after taking according to the method described above medicine of the present invention month, learns that through investigation and interview its malaise symptoms disappears, eyeballDry and astringent symptom improves.

(3) patient female, 30 years old, does accounting one duty in certain company, owing to often facing computer screen, its eyes screen curtain of a specified durationAfter there will be the symptoms such as blurred vision, dry and astringent, dim eyesight, gum secretion increasing, take according to the method described above one of medicine of the present inventionAfter month, above-mentioned symptom improves and without other senses of discomfort, and looking that the present invention causes depending on, liver-fire flaming for a long time for alleviation be describedFatigue has mitigation.

Detailed description of the invention

Embodiment 1; (1) take Radix Astragali 2000g, cicada slough 2500g, Radix Angelicae Sinensis 2000g, fruit of Chinese wolfberry 4000g, cassia seed 1000g,Chrysanthemum 500g, red date 1000g and Radix Glycyrrhizae 500g;

(2) bulk drug of step (1) is used to 135kg water soaking 2 hours, heating decocts 1.5 hours, and decoction liquor is filtered and to be obtained the first filterLiquid; The dregs of a decoction add the heating of 120kg water again and decoct 100 minutes, and decoction liquor is filtered to obtain the second filtrate; Merge the first filtrate and the second filterLiquid, obtains supernatant;

(3) gained supernatant is filtered, be concentrated in right amount, add appropriate amount of ethanol and make precipitation, get supernatant decompression recycling ethanol, add waterStir, leave standstill 12h. Get supernatant and filter, filtrate is concentrated; Separately merge in right amount with sucrose, sorbic acid, stir, add pure water constant volumeTo total amount be 40,000 ml, adjust pH value be 6.0, refrigeration, filter, sterilizing, filling. Specification: every 20ml. Dose: one day 3Inferior, one time 1.

Embodiment 2; (1) take Radix Astragali 3000g, cicada slough 2000g, Radix Angelicae Sinensis 2500g, fruit of Chinese wolfberry 3000g, cassia seed 500g,Chrysanthemum 1000g, red date 500g and Radix Glycyrrhizae 1000g;

(2) bulk drug of step (1) is used to 135kg water soaking 2.5 hours, heating decocts 2 hours; Decoction liquor is filtered to obtain the first filterLiquid; The dregs of a decoction add the heating of 110kg water again and decoct 2 hours, and decoction liquor is filtered to obtain the second filtrate; Merge the first filtrate and the second filtrate,Obtain supernatant;

(3) be 1.06 o'clock by supernatant concentration to relative density, enter spray dryer, 175 DEG C of EATs, leaving air temp 85DEG C, charging rate is 300ml/min, obtains spray dried powder 3250g.

(4) by spray dried powder and starch 850g, sodium carboxymethyl starch 100g mixes, by 60% ethanol adjustment humidity systemGrain, 65 DEG C dry, adds dolomol 20g, with compressing tablet after the whole grain of 14 mesh sieves. Specification: 0.4g/ sheet. Dose: 3 times on the one,One time 5.

Embodiment 3; (1) take Radix Astragali 2500g, cicada slough 2500g, Radix Angelicae Sinensis 3000g, fruit of Chinese wolfberry 2000g, cassia seed 700g,Chrysanthemum 1000g, red date 800g, Radix Glycyrrhizae 1000g;

(2) bulk drug of step (1) is used to 120kg water soaking 3 hours, heating decocts 1.5 hours, and decoction liquor is filtered and to be obtained the first filterLiquid; The dregs of a decoction add the heating of 110kg water again and decoct 2 hours, and decoction liquor is filtered to obtain the second filtrate; Merge the first filtrate and the second filtrate,Obtain supernatant;

(3) be 1.07 o'clock by supernatant concentration to relative density, enter spray dryer, 180 DEG C of EATs, leaving air temp 90DEG C, charging rate is 250ml/min, obtains spray dried powder 3220g.

(4) spray dried powder is mixed with starch 800g, with 60% ethanol adjustment humidity softwood processed, by 14 mesh sievesMake after single-size, 65 DEG C dry, adds dolomol 32g, and whole grain sieves, encapsulated. Specification: 0.4g/ grain. Dose:3 times on the one, one time 5.

Embodiment 4; (1) take: Radix Astragali 2800g, cicada slough 3000g, Radix Angelicae Sinensis 2000g, fruit of Chinese wolfberry 3000g, cassia seed 800g,Chrysanthemum 600g, red date 600g, Radix Glycyrrhizae 700g;

(2) bulk drug of step (1) is soaked 2 hours with 120kg water soaking times water gaging, heating decocts 2 hours, and decoction liquor is filteredObtain the first filtrate; The dregs of a decoction add the heating of 135kg water again and decoct 2 hours, and decoction liquor is filtered to obtain the second filtrate; Merge the first filtrate andTwo filtrates, obtain supernatant;

(3) be 1.05 o'clock by supernatant concentration to relative density, enter spray dryer, 185 DEG C of EATs, leaving air temp 85DEG C, charging rate is 350ml/min, obtains spray dried powder 3300g.

(4) by spray dried powder and sucrose 4850g, dextrin 1650g is uniformly mixed, and with 60% ethanol softwood processed, granulates, and driesDo to obtain granule. Specification: 5g/ bag. Dose: 3 times on the one, one time 1 bag.

Claims (3)

1. a Chinese medicine composition with asthenopia releasing function, is characterized in that the bulk drug system by following weight proportioningBecome: 200 ~ 300 parts of the Radixs Astragali, 200 ~ 300 parts of cicada sloughs, 200 ~ 300 parts of Radix Angelicae Sinensis, 200 ~ 400 parts of the fruits of Chinese wolfberry, 50 ~ 100 parts of cassia seeds,50 ~ 100 parts of 50 ~ 100 parts of chrysanthemums, red date and 50 ~ 100 parts, Radix Glycyrrhizae.

2. a kind of Chinese medicine composition with asthenopia releasing function according to claim 1, is characterized in that preferredBulk drug weight proportion is: 200 parts of the Radixs Astragali, 250 parts of cicada sloughs, 200 parts of Radix Angelicae Sinensis, 400 parts of the fruits of Chinese wolfberry, 100 parts of cassia seeds, chrysanthemum 50Part, 100 parts of red dates and 50 parts, Radix Glycyrrhizae.

3. one kind has the preparation method of the Chinese medicine composition of asthenopia releasing function; Step comprises:

(1) according to 200 ~ 300 parts of the Radixs Astragali, 200 ~ 300 parts of cicada sloughs, 200 ~ 300 parts of Radix Angelicae Sinensis, 200 ~ 400 parts of the fruits of Chinese wolfberry, cassia seed 50The weight portion proportioning of 50 ~ 100 parts of ~ 100 parts, 50 ~ 100 parts of chrysanthemums, red date and 50 ~ 100 parts, Radix Glycyrrhizae, weighting raw materials;

(2) step (1) bulk drug is entered to container, add 8～10 times of weight parts waters of bulk drug and soak 2～3 hours, heating decocts 1.5～2 hours, decoction liquor was filtered to obtain the first filtrate; The dregs of a decoction add 8～10 times of weight parts waters again, and heating decocts 1.5～2 hours, decoctLiquid filters to obtain the second filtrate; Merge the first filtrate and the second filtrate, obtain supernatant;

(3) by supernatant routinely technique be prepared into oral liquid; Or,

(4) supernatant will be concentrated into relative density is 1.04～1.07 o'clock, enters spray dryer, EAT 170～185DEG C, 85～90 DEG C of leaving air temps, charging rate 250～350ml/min, obtains spray dried powder;

(5) by spray dried powder according to conventional pharmaceutical methods, add pharmaceutically acceptable auxiliary material or complementary composition, makeSaid conventional solid orally ingestible in acceptable, pharmacy, comprises granule or tablet or capsule clinically.