CN103859378A - Formula and preparation method of life cultivation and health preservation food helpful for reducing blood sugar - Google Patents
Formula and preparation method of life cultivation and health preservation food helpful for reducing blood sugar Download PDFInfo
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- CN103859378A CN103859378A CN201210532275.0A CN201210532275A CN103859378A CN 103859378 A CN103859378 A CN 103859378A CN 201210532275 A CN201210532275 A CN 201210532275A CN 103859378 A CN103859378 A CN 103859378A
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
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- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention provides a formula and a preparation method of a life cultivation and health preservation food helpful for reducing blood sugar. The formula of the food comprises, by weight, 600-1400 parts of wolfberry fruit, 600-1500 parts of Polygonatum sibiricum, 600-1500 parts of Poria cocos, 1000-2000 parts of Chinese yam, 800-1300 parts of mulberry fruit, 1000-2000 parts of Radix Puerariae, 600-1200 parts of dark plum, 900-1500 parts of cassia seed, 200-1000 parts of licorice root, 500-1000 parts of mulberry leaf and 600-1200 parts of lily. The preparation method adopts a traditional water decoction extraction process, and obtained extract products are directed put in bags, so the method is simple, and the food can be conveniently administrated The food is used for treating hyperglycemia, and can effectively alleviate three polys and one little, lassitude, slow response and clumsy fingers of hyperglycemia people.
Description
Technical field
The invention discloses one and contribute to fall hypoglycemic health preserving health-care food formula and preparation method thereof.
Background technology
Under normal circumstances, human body can be regulated with this two large regulating system of nerve regulation and be guaranteed that the source of blood sugar and outlet keep balance, make blood sugar maintain certain level by hormone.But under the acting in conjunction of inherent cause (as diabetes family history) and environmental factor (as irrational meals, obesity etc.), two large regulatory functions get muddled, and just there will be the rising of blood sugar level.Long-term hyperglycaemia can make each histoorgan generation pathology of whole body, causes the generation of acute and chronic complication.As pancreas function exhaustion, dehydration, electrolyte disturbance, nutritional deficiency, resistance decline, impaired renal function, DPN, eyeground pathological changes etc.
The mankind's healthy living, closely related with stablizing of external environment (as air, water source) and interior environment (as blood, tissue fluid).The too high interior environment that has destroyed just human body of blood sugar, causes a series of biochemical pathological changes, has affected the function of each internal organs.For healthy, we should be positively by glucostasis in normal range (NR), prevent or delay the generation of complication.
Summary of the invention
The object of this invention is to provide one and contribute to fall hypoglycemic health preserving health-care food formula and preparation method thereof.
The present invention is made up of the raw material of following portions by weight: fruit of Chinese wolfberry 600-1400 part, sealwort 600-1500 part, Poria cocos 600-1500 part, Chinese yam 1000-2000 part, mulberry fruit 800-1300 part, root of kudzu vine 1000-2000 part, dark plum 600-1200 part, cassia seed 900-1500 part, Radix Glycyrrhizae 200-1000 part, mulberry leaf 500-1000 part, lily 600-1200 part.
The optimum weight proportioning of each composition is above: 1000 parts of the fruits of Chinese wolfberry, 1000 parts of sealworts, 1000 parts, Poria cocos, 1500 parts of Chinese yams, 1000 parts of mulberries, 1500 parts of the roots of kudzu vine, 900 parts of dark plums, 1200 parts of cassia seeds, 600 parts, Radix Glycyrrhizae, 700 parts, mulberry leaf, 900 parts of lilies.
One, preparation method of the present invention comprises the following steps:
(1) each raw material in formula is placed in to boil carries pot, infiltrate 30 minutes, then add the deionized water of 10 times of amounts, soaking at room temperature is heated to boiling after 2 hours, boils and extracts 2 hours, and the water outlet extract that inclines, filters.
(2) again add the deionized water of 10 times of amounts of raw material, boil and extract 2 hours, the water outlet extract that inclines, filters.
(3) combining step (1), (2) gained filtrate, be cooled to room temperature, and centrifugal 30 minutes, discard precipitation, collect supernatant.
(4) filtrate of step (3) gained being concentrated into liquid ratio is 1: 2 (60 ℃), adds natural absorptive clarificant (Beijing Zheng Tiancheng clarification technique Co., Ltd), centrifugal 30 minutes, discard precipitation, and collect supernatant;
(5) by the supernatant concentration of step (4) gained to relative density>=1.27gml
-1(60 ℃), dry, pulverize, and are distributed into the inner wrapping of 10 grams.
Rationally, manufacture craft science, carries and instant formula composition of the present invention.Long-term invented food effectively stabilizing blood sugar level, in normal range (NR), is removed hyperglycemia crowd's worry.
Two, analysis of drug use
The fruit of Chinese wolfberry is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..
[nature and flavor with return through] are sweet, flat.Return liver, kidney channel.
[effect] is nourishing liver and kidney, benefiting shrewd head.
Hypopsia, the cataract or glaucoma blurred vision of [application] treatment due to asthenia of essence and blood, have a dizzy spell, soreness and weakness of waist and knees, seminal emission lingering diarrhea, deafness, tooth mobility, poliosis, insomnia and dreamful sleep and the deficiency of liver-yin and kidney-yin, hectic fever night sweat, the card such as quench one's thirst.
Shennong's Herbal claims the fruit of Chinese wolfberry " to take for a long time hard muscles and bones, make light of one's life by commiting suicide not old, cold-resistant heat ".
" book on Chinese herbal medicine converge with speech " praises it " gas can be filled, and blood can be mended, Yang Kesheng, the moon can be grown ".
Compendium of Material Medica is recorded: " matrimony vine, kidney-tonifying sperm-generating, nourishing the liver, improving eyesight, hard muscles and bones, goes fatigue, and easily color, bleaches, and improving eyesight is calmed the nerves, and makes us long-lived.”
Modern medicine study confirms: the fruit of Chinese wolfberry contains betaine, polysaccharide, crude fat, crude protein, carrotene, vitamin A, vitamin C, Cobastab
1, Cobastab
2and the nutritional labeling such as calcium, phosphorus, iron, zinc, manganese, linoleic acid.The fruit of Chinese wolfberry has facilitation to immunity, has immunoregulation effect simultaneously; Can improve plasma testosterone level, play strong effect; Hematopoiesis function is had to facilitation; Normal healthy people is also had to remarkable effect in increasing leukocyte; Anti-oxidant, anti-ageing, antifatigue, anti-sudden change, antitumor, reducing blood lipid in addition, protect the liver and the function such as AFL, hypoglycemic, hypotensive, kidney tonifying, improving eyesight, beauty treatment, brain tonic, toxin expelling, protection reproductive system, Antiradiation injury.
Sealwort is the dry rhizome of liliaceous plant Yunnan sealwort (Polygonatum kingianum Coll.et Hemsl.), sealwort (Polygonatum sibiricum Red.) or David's-harp (Polygonatum cyrtonema Hua.).
[nature and flavor with return through] are sweet, flat.Return spleen, lung, kidney channel.
[effect] boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.
Cough chronic cough, weakness of the spleen and the stomach, fatigue and asthenia, poor appetite, dry food of the few phlegm of dry cough of [application] treatment lung gold impairment of both QI and YIN, the labor of lung-kidney deficiency is few, can delay senility, and improves dizziness, soreness and weakness of waist and knees, poliosis, asthenia of essence and blood, the interior heat disease such as quench one's thirst.
Compendium of Material Medica: " mend all void, stop fever and chills, replenishing essence marrow.”
" Japan hanako materia medica ": " mend general debility, help muscles and bones, myogenic, cold-resistant heat, beneficial taste, profit cardiopulmonary ".
Modern medicine study confirms: sealwort rhizome contains nicotinic acid, mucilaginous substance, quinones, and containing Siberian solomonseal rhizome polysaccharide first, second, the third, polygonatum rhizome oligosaccharide first, second, the third, polysaccharide first, second, third is combined into by glucose, mannose, galacturonic acid; Compound sugar first, second, third is combined into by glucose and fructose, separately containing 11 seed amino acids such as lysines.Can improve body's immunity and promote the synthetic of DNA, RNA and protein, promote lymphocyte transformation effect; There is significant anti-mycobacterium tuberculosis effect; Multiple pathogenic fungus is had to inhibitory action; Typhoid bacillus, staphylococcus aureus are also had to inhibitory action; There is coronary flow and the hypotensive effect of increasing, and can reducing blood lipid and alleviate Coronary Artery Atherosclerosis; Blood sugar that adrenaline is caused is too high is remarkable inhibitory action; Suppress in addition adrenocortical effect and delaying senility function; Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.
Poria cocos is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf.
[nature and flavor with return through] are sweet, light, flat.The thoughts of returning home, lung, spleen, kidney channel.
[effect] clearing damp and promoting diuresis, the peaceful heart of invigorating the spleen.
[application], for oedema oliguria, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, and have loose bowels in loose stool, confused and worried, palpitation with fear insomnia.
" Japan hanako materia medica ": " mend general debility, antiabortive, warm waist knee, happy intelligence development, only forgetful.”
" medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria cocos, the sharp key of light energy.The sweet flat yang-tonifying of taste, beneficial spleen is relieved oedema or abdominal distension through diuresis or purgation, the air guide of promoting the production of body fluid.”
Modern medicine study confirms: Poria cocos energy enhanced machine body immunity function, pachymaran has anti-atrophy of thymus gland and anti-splenomegaly and suppresses the function of tumor growth, pachymaran gavage can strengthen macrophage phagocytosis of mice, increase ANAE positive lymphocyte number, can also make mouse spleen antibody secreting cell count showed increased.Pachymaran also can make the caused big white mouse leucocyte of endoxan reduce and accelerate rise.Carboxymethylpachymaran also have immunological regulation, protecting liver, lowering enzymes, indirectly antiviral, induce and short inducement interferon, alleviate radiation side reaction, induce and urge to induce the multiple physiologically actives such as leukoregulin.
Chinese yam is the dry rhizome of Dioscoreaceae plant Chinese yam Dioscorea opposite Thumb..
[nature and flavor with return through] are sweet, flat.Return lung, spleen, kidney channel.
[effect] tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying.
The sweet property of [application] Chinese yam taste is flat, and effect relaxes, cold not hot, can tonifying Qi, again can yin-nourishing, and tonify without causing stagnation, grows and oiliness.It is the good merchantable brand of flat tonifying lung spleen kidney.Be used for becoming thin weak, food less, loose stool person, as Compendium of Material Medica cloud: " kidney-nourishing gas, strengthening the spleen and stomach." because it contains more nutritional labeling, easily digest and assimilate again, can be used as food and use for a long time.Shennong's Herbal cloud its " bowl spares, beneficial strength, longue meat ", thus for chronic disease or weak after being ill, need nutrition to adjust to mend and dysfunction of the spleen person is good merchantable brand, as seed of Job's tears yam porridge.
Modern medicine study confirms: the main component of Chinese yam is amylase, can move in stimulating gastrointestinal road, promotes that in intestines, thing is emptying, increases Small Intestinal, contributes to digestion, step-down, hypoglycemic, prevention and cure of cardiovascular disease.The purification starch of Chinese yam can reduce lipid concn, reduces the sugared concentration of sustainer and heart and the concentration of cholesterol simultaneously.Chinese yam is rich in polysaccharide, can stimulate and regulate immune system, can increase blood leucocyte content, strengthens leukocytic phagocytosis, and therefore Chinese yam can be used as people increases the health care medicinal of immunocompetence.In Chinese yam, contain the active ingredients such as protein (comprising 16 seed amino acids that needed by human body is wanted), carbohydrate, vitamins, there is the effect delaying senility preferably, significant prolongation life, often edible Chinese yam, good for health.
Mulberry fruit is the dry fruit ear of moraceae plants mulberry Morus alba L..
[nature and flavor with return through] are sweet, sour, cold.Return liver, kidney channel.
[effect] nourishing yin and supplementing blood, promotes the production of body fluid and moisturizes.
[application] is applicable to that dizzy tinnitus, palpitation and insomnia, poliosis, thirsty, the interior heat of Tianjin wound are quenched one's thirst, blood deficiency and constipation, order are dark, tinnitus, scrofula, articular instability.
" the southern regions of the Yunnan Province book on Chinese herbal medicine ": " kidney-nourishing is dirty and controlling nocturnal emission with astringent drugs takes black invention order for a long time.”
" with breath living in seclusion recipe ": " wines used as antirheumatic, walks with vigorous strides to carry out, and ceases empty wind, the clear fire of deficiency type for nourish liver and kidney, enrich blood.”
Supplement to the Herbal: " sharp the five internal organs joint, logical vim and vigour.Clothes are not hungry for a long time, and spirit sedation, makes us clever, bleaches not old.”
Modern medicine study confirms: mulberry fruit is sugary, tannic acid, malic acid and Cobastab
1, B
2, C and carrotene.The aliphatic acid of Fructus Mori oil is mainly made up of linoleic acid and stearic acid, oleic acid etc.Be improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and Wu Fa of skin, and can delay senility, and is be healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food mulberry fruit can improving eyesight, the symptom that relieving eye strain is dry and astringent.Mulberries have immunologic enhancement, and spleen is had to effect of gain, and to hemolytic, reaction has humidification, can prevent human body artery sclerosis, bone arthrosclerosis, enhance metabolism.It can promote the growth of erythrocyte, prevents that leucocyte from reducing, and the illnesss such as treatment diabetes, anaemia, hypertension, high fat of blood, coronary heart disease, neurasthenia are had to auxiliary effect.Proper amount of edible can promote gastric secretion, stimulates enterocinesia and removes scorching.
The root of kudzu vine is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.
[nature and flavor with return through] are sweet, pungent, cool.Return spleen, stomach, lung channel.
[effect] relieving muscles to expel heat, promotes the production of body fluid to quench thirst, and promoting eruption rises positive antidiarrheal, clearing and activating the channels and collaterals, relieving alcoholism.
[application] has a headache for fever caused by exogenous pathogens, and stiff nape and back is thirsty, quench one's thirst, and measles without adequate eruption, hot dysentery, has loose bowels, dizziness and headache, hemiplegia, chest impediment and cardialgia, in wine poison wound.
Compendium of Material Medica: " root of kudzu vine, cool in nature, gas is flat, taste is sweet, tool heat-clearing, falls fire, all effects of toxin expelling.”
" book on Chinese herbal medicine justice ": " can develop the gas of the clear sun of taste.”
Modern medicine study confirms: the main carbohydrate containing of the root of kudzu vine, vegetable protein, multivitamin, amino acid and mineral matter, contain in addition Flavonoid substances: Dai, daidzin, also has Dai-4,7-diglucoside, Puerarin, Puerarin-7-xyloside, root of kudzu vine alcohol, root of kudzu vine rattan and daidzin etc.Isoflavonoid Puerarin in the root of kudzu vine has certain curative effect to hypertension, high fat of blood, hyperglycaemia and cardiovascular and cerebrovascular disease.The flavones proposing in the root of kudzu vine can increase brain and crown vascular flow amount.Find after deliberation the content of isoflavones in elegant jessamine with active far above soybean, often eat the beauty treatment of elegant jessamine food energy looks, promote whitening skin, smoothness, exquisiteness, make women's brilliance that radiates the vigour of youth, climacteric metancholia is had to opsonic action simultaneously.With age, health reduces the absorption of calcium, and calcium reduces, and bone decalcification, osteoporosis easily occurs, and often edible elegant jessamine goods can prevention of osteoporosis.
Dark plum is the dry almost ripe fruit of rose department plant plum Prunus mume (Sieb.) Sieb.et Zucc..When the nearly maturation of fruit in summer, gather, vexed to look blackening after low temperature drying.
[nature and flavor with return through] acid, puckery, flat.Return liver, spleen, lung, large intestine channel.
[effect] astringes the lung, and puckery intestines, promote the production of body fluid, claming ascaris.
[application], for chronic cough of deficiency lung, rushes down protracted dysentery for a long time, and abnormal heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache.
" herbal classic ": main lower gas, heat extraction dysphoria, feels at ease, and limbs pain is hemiplegia meciless, and dead flesh removes blue or green black mole, dislikes meat.
" not Lu ": only diarrhea, good saliva dry.Li Jinmai, goes numbness.
" detailed outline ": the puckery intestines of astringing the lung, control for a long time and cough, rush down dysentery, gastric disorder causing nausea is dysphagic, and the ascariasis of biliary tract tells profit, and detumescence, gushes phlegm, and desinsection is separated ichthyotoxin, horse sweat poison, Sulfur poison.
Modern medicine study confirms: water decocted solution of fructus mume (1: 1) all has inhibitory action to bacillus anthracis, diphtheria and diphtheroid, hay bacillus, staphylococcus (golden yellow, lemon yellow, white), pneumococcus, also effective to pathogenic bacteria in the intestines such as Escherichia coli, bacterium sonnei, proteus, Typhoid and paratyphoid bacillus, Pseudomonas aeruginosa, comma bacillus; The effect that dark plum has excitement, stimulates roundworm to retreat roundworm; Dark plum can increase the secretion of bile, and can make bile be tending towards acid, has increase appetite, promotes digestion, the effect of saliva stimulating gland, gastric gland secrete digestive juices; Also there is significant whole intestines effect, promote enterocinesia, diminish inflammation; There is again the effect of shrinking intestines wall, thereby can be used for the treatment of diarrhoea simultaneously.
Cassia seed is the dry mature seed of legume Cassia tora Cassia obtuse folia L. or little Cassia tora Cassia tora L..
[nature and flavor with return through] are sweet, bitter, salty, are slightly cold.Return liver, large intestine channel.
[effect] removing heat to brighten vision, relaxes bowel.
[application], for the puckery pain of hot eyes, the many tear of photophobia, has a headache dizzy, and order is secretly not clear, constipation.
" herbal classic ": control glaucoma, the red tunica albuginea of the excessive skin of order, swelling ophthalmalgia, lacrimation, clothes benefit is with nothing left for a long time.
" not Lu ": treat blue-purple lips.
" property of medicine opinion ": sharp the five internal organs, except liver man heat.
" Japan hanako materia medica ": help irritability, beneficial smart water; Adjust end to be coated with, detumescence poison, Xie temple are controlled headache, paste again the brain heart and stop nosebleed epistaxis; Make pillow victory black soya bean, control a wind, improving eyesight.
Modern medicine study confirms: cassia seed contains multivitamin and abundant amino acid, fat, carbohydrate etc., has the functions such as clearing away the liver-fire, wines used as antirheumatic, tonifying kidney and improving eyesight, often drinks cassia-tora tea, can make blood pressure normal, free movement of the bowels, and old eye is not spent.Clinical trial certificate, drinks cassia-tora tea and can clear liver and improve vision, prevent eye-blurred, hypotensive, reducing blood lipid, minimizing cholesterol etc., for preventing and treating coronary heart disease, hypertension has good curative effect; And cassia seed is rich in vitamin A and zinc, can prevents and treats yctalopia and avoid zinc deficiency in children.In addition, the function that cassia-tora tea relaxes bowel also can solve the problem of modern's stomach and constipation, can treat dry feces, helps smooth defecation.
Radix Glycyrrhizae is dry root and the rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., glycyrrhiza inflate bat Glycyrrhiza inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..
[nature and flavor with return through] are sweet, flat.The thoughts of returning home, lung, spleen, stomach warp.
[effect] invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
[application] for weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
" medicine justice ": Radix Glycyrrhizae, it is raw that with cool and purging intense heat, main loose table is evil, subduing inflammation, relieve sore throat pain, separates hundred medicine poison, except stomach accumulated heat, goes urinary catheter bitterly, and the power of this sweet cool heat extraction is also.Process with temperature and bowl spares, main insufficiency of the spleen cunning is rushed down, and stomach void is thirsty, and fever and chills cough, breathes hard sleepy, and forced labour is deficient, and the merit that this sweet temperature helps spleen also.But rich and too sweet, unsuitable multiplex in tonic, probably love diaphragm and do not think food also.
Modern medicine study confirms: Radix Glycyrrhizae has the function of anti-inflammatory and resistance state reflection, therefore in doctor trained in Western medicine clinically mainly as moderator.Radix Glycyrrhizae energy relieving cough, eliminates the phlegm, treatment pharyngalgia, sphagitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, and chronic adrenocortical hypofunction is had to good efficacy; Glycyrrhiza preparation can promote stomach mucus to form and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavones of Radix Glycyrrhizae has anti-inflammatory, spasmolysis and antiacid effect.
Mulberry leaf are the dry leaf of moraceae plants mulberry Morus alba L..
[nature and flavor with return through] are sweet, bitter, cold.Return lung, Liver Channel.
[effect] dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clears liver and improve vision.
[application] for anemopyretic cold, lung-heat type cough, and dizziness headache, hot eyes is dim-sighted.
Compendium of Material Medica: mulberry leaf are hand, the bright medicine of foot sun, control labor heat cough, and improving eyesight long hair, only quenches one's thirst.
" herbal classic is met former ": mulberry leaf clearing lung-heat stomach, dispelling pathogenic wind for improving eyesight.The white person that learns from else's experience decocts soup, washes tear under the eye of wind.Take for a long time with Semen sesami nigrum honeyed bolus, beard and hair is not white, does not always prolong life.
" herbal classic " speech is perspired except fever and chills, and " bright greatly " cooks the meaning of smashing the perspiration of box wind pain.Decoct the sharp the five internal organs of drink, the lower gas of getting round by bribery.Decoct wine clothes, control a wind cutting.Mulberry root ashing drenches juice, and with lime point face windward, the mole of going out, removes to dislike meat.
Modern medicine study confirms: in mulberry leaf, be rich in the chemical compositions such as flavonoids, alkaloids, phytosterol, GABA, polysaccharide.Having hypotensive, reducing blood lipid, hypoglycemic, norcholesterol, anticoagulation, antithrombotic forms and study of anti-atherogenic effect; Antibacterial, anti-inflammatory, antiviral, antitumor action; Anti-ageing, antifatigue effect.Also be improved gastrointestinal function, relax bowel and antiobesity action.
Lily is the dry Rou Zhi of the Gan Scales leaf of liliaceous plant tiger lily Lilium lancifolium Thunb, lily L ilium brownii F.E.Brown var.viridulum Baker or Lilium tenuifolium Lilium pumilum DC.
[nature and flavor with return through] are sweet, cold.The thoughts of returning home, lung channel.
[effect] Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing.
[application] for deficiency of Yin cough caused by dryness, the labor hemoptysis of coughing, and dysphoria palpitation with fear, insomnia and dreamful sleep, absent-minded.
Shennong's Herbal: taste is sweet is flat.Cure mainly perverse trend abdominal distension, pained, sharp stool, urine, tonifying middle-Jiao and Qi.
" book on Chinese herbal medicine ": main perverse trend abdominal distension is pained, sharp stool and urine, tonifying middle-Jiao and Qi, except edema set out swollen, the full fever and chills of ruffian, pain all over, and newborn difficult larynx numbness, only tears.
" Japan hanako materia medica ": feel at ease, determine courage, beneficial will, supports five and hide, and controls insane heresy, weeps, mad crying, and palpitation with fear, kills disease due to noxious agents produced by various parasites gas, and carbuncle in hypochondriac region acute mastitis carbuncle on the back and all sores are swollen, and the mad fortune of blood after managing property.
Modern medicine study confirms: lily is except containing protein 21.29%, fat 12.43%, reduced sugar 11.47%, starch 1.61%, and calcium, phosphorus, iron, every hectogram are containing outside the nutrients such as 1.443 milligrams of Cobastabs, 21.2 milligrams of vitamin Cs, also contain some special nutritional labelings, as multiple alkaloids such as colchicins.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also multiple Seasonal diseases dry in autumn and that cause is had to certain preventive and therapeutic effect.In the traditional Chinese medical science, say that fresh lily bulb has mental-tranquilization, the effect moistening the lung and relieve the cough, is highly profitable to weakling after being ill.Lily also has kobadrin, calmness, the effect such as strong, anticancer.
Three, function assessment evaluation
The impact of invention product on diabetic mice fasting blood-glucose and sugar tolerance
[experimental animal]
120 of Kunming mouses, male, body weight 25～30g.
[test method]
1, zoic model with hyperglycemia is set up
Mouse adaptability is fed after 3d, gets 100 fasting (can't help water) 12h, chamber abdomen injection alloxan (120mg/kg), the physiological saline of blank group injection equivalent.After 3d, after fasting 12h, get hematometry fasting blood-glucose from endocanthion, take blood glucose value higher than 10.0mmol/L as diabetic mice model.90 of modeling successes.
2, animal grouping and administration:
Select 40 diabetic mices to be divided at random 4 groups, every group 10, be respectively model control group, the basic, normal, high dosage group of invention product (2.5g/kg, 5g/kg, 10g/kg), selects 10 normal mouses else as Normal group (not modeling).Press 0.2ml/10g volume to mouse gavage every day 1 time, Normal group and model control group give equal-volume distilled water, continuously gavage 4 weeks.
3, experimental procedure:
3.1 reduce the experiment of mouse fasting blood-glucose
40 diabetic mices by grouping and the administration of medication last after, fasting 4h but can't help water, gets blood from angular vein, utilizes determination of glucose oxidase respectively to organize the fasting blood-glucose of mouse.The fasting blood sugar of more each experimental group and model control group and blood sugar decline percentage.Blood glucose value × 100% before blood sugar decline percentage (%)=(blood glucose value after the front blood glucose value-administration of administration)/administration.
3.2 sugar tolerance experiments
40 diabetic mices by grouping and the administration of medication last after, fasting 4h but can't help water, then give and be once subject to test solution.After 15min, each group gavage gives glucose solution (2.0g/kg), respectively at giving after glucose 0,0.5,2h is from angular vein measuring blood sugar of blood extracting value, calculate as follows each treated animal and ask an Area under the curve of blood glucose when each after to glucose: Area under the curve of blood glucose AUC=0.25 × (0h blood glucose value+4 × 0.5h blood glucose value+3 × 2h blood glucose value).
[result of the test]
1, the impact of invention product on diabetic mice fasting blood-glucose
After the modeling of injection alloxan, respectively organize the fasting blood sugar of mouse far above 10mmol/L.Give mouse invention product after 4 weeks, the fasting blood sugar of each dosage group is all lower than model control group; Blood sugar decline percentage is all higher than model control group, after the administration of invention product low dose group, blood glucose value and model control group relatively have significant difference (P < 0.05), and after the administration of the middle and high dosage group of invention product, blood glucose value and model control group relatively have utmost point significant difference (P < 0.01).The blood sugar decline percentage of the basic, normal, high dosage group of invention product and model control group relatively have utmost point significant difference (P < 0.01).In table 1.
The impact of table 1 invention product on diabetic mice fasting blood-glucose
n=10
Note: with model control group comparison, * P < 0.05, * * P < 0.01.
2, the impact of invention product on diabetic mice sugar tolerance
With normal group comparison, the sugar tolerance Area under the curve of blood glucose AUC of model group significantly raises (P < 0.01), and the glucose tolerance level of prompting mouse is badly damaged.The administration of invention product is after 4 weeks, and with model group comparison, basic, normal, high three dosage group AUC all decline to some extent, and wherein the AUC of middle and high dosage group and model control group relatively have utmost point significant difference (P < 0.01).Result shows, invention product can improve the tolerance of diabetic mice to glucose.In table 2.
The impact of table 2 invention product on diabetic mice sugar tolerance
n=10
Note: with Normal group comparison, ##P < 0.01; With model control group comparison, * P < 0.05, * * P < 0.01.
[conclusion (of pressure testing)]
Test and sugar tolerance experiment by diabetic mice fasting blood-glucose, prove that invention product has certain hypoglycemic activity, and contribute to improve the tolerance of diabetic mice to glucose.
The specific embodiment
The preparation of embodiment 1 extract and product
Take 1000 parts of the fruits of Chinese wolfberry, 1000 parts of sealworts, 1000 parts, Poria cocos, 1500 parts of Chinese yams, 1000 parts of mulberries, 1500 parts of the roots of kudzu vine, 900 parts of dark plums, 1200 parts of cassia seeds, 600 parts, Radix Glycyrrhizae, 700 parts, mulberry leaf, 900 parts of lilies by optimum weight proportioning.Adding 10 times of amount deionization poach carries 2 times, each 2 hours, leach cooking liquid filtration, centrifugal (3000 revs/min) 30 minutes, get supernatant, be concentrated into liquid than 1: 2 (60 ℃), after add natural absorptive clarificant (4% fining agent A, 8% fining agent B), then centrifugal (3000 revs/min) 30 minutes, get supernatant and continue to be concentrated into relative density>=1.27gml
-1after (60 ℃), belt drying, is ground into fine powder, is distributed into the inner wrapping of 10 grams of left and right.
Embodiment 2 product adjuvant therapy of diabetes
Case report
Lee × ×, female, 53 years old.By diagnosis type ii diabetes, there is many foods, many drinks, diuresis, lassitude hypodynamia, slow in reacting, finger movement is ineffective, do not want to walk, night the symptom such as Leg Cramps, take 3 bags of product of the present invention every days, after continuous 4 months, Fasting Glucose value declines to some extent, and many foods, many drinks, diuresis symptom alleviate, the health state of mind takes a turn for the better, and the phenomenon that knots no longer appears in shank.
Claims (4)
1. contribute to fall a hypoglycemic health preserving health-care food formula, it is characterized in that raw material used and parts by weight thereof: fruit of Chinese wolfberry 600-1400 part, sealwort 600-1500 part, Poria cocos 600-1500 part, Chinese yam 1000-2000 part, mulberry fruit 800-1300 part, root of kudzu vine 1000-2000 part, dark plum 600-1200 part, cassia seed 900-1500 part, Radix Glycyrrhizae 200-1000 part, mulberry leaf 500-1000 part, lily 600-1200 part.
2. one according to claim 1 contributes to fall hypoglycemic health preserving health-care food formula, it is characterized in that raw material used and optimum weight proportioning thereof: 1000 parts of the fruits of Chinese wolfberry, 1000 parts of sealworts, 1000 parts, Poria cocos, 1500 parts of Chinese yams, 1000 parts of mulberries, 1500 parts of the roots of kudzu vine, 900 parts of dark plums, 1200 parts of cassia seeds, 600 parts, Radix Glycyrrhizae, 700 parts, mulberry leaf, 900 parts of lilies.
3. one according to claim 1 and 2 contributes to fall hypoglycemic health preserving health-care food formula and preparation method thereof, it is characterized in that preparation process carries out according to the following steps:
(1) each raw material in formula is placed in to boil carries pot, infiltrate 30 minutes, then add the deionized water of 10 times of amounts, soaking at room temperature 2 hours; Then be heated to boiling, boil and extract 2 hours, the water outlet extract that inclines, filters;
(2) again add the deionized water of 10 times of amounts of raw material, boil and extract 2 hours, the water outlet extract that inclines, filters;
(3) combining step (1), (2) gained filtrate, cooling, centrifugal, discards precipitation, collects supernatant;
(4) filtrate of step (3) gained is concentrated, add natural absorptive clarificant, discard precipitation, collect supernatant;
(5) by the supernatant concentration of step (4) gained, dry, pulverize, be distributed into the inner wrapping of 10 grams.
4. one according to claim 1 and 2 contributes to fall hypoglycemic health preserving health-care food formula, it is characterized in that: the present invention is for hyperglycemia the symptom such as effectively alleviate hyperglycemia crowd " three-many-one-little ", lassitude hypodynamia, slow in reacting, finger movement is ineffective.
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| CN106728868A (en) * | 2016-12-28 | 2017-05-31 | 陕西红顶名医堂药业有限公司 | Chinese medicine composition and preparation method thereof for treating diabetes |
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Application publication date: 20140618 |