CN101632769A - Chinese medicinal composition for regulating blood sugar and preparation method thereof - Google Patents
Chinese medicinal composition for regulating blood sugar and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicinal composition for regulating blood sugar and a preparation method thereof. The composition can be prepared into health-care foods or medicaments, and is mainly suitable for people with high blood sugar and diabetes. The active component consists of at least the following six raw material medicaments: fiveleaf gynostemma herb, hawthorn fruit, yam, dark plum fruit, mulberry fruit and mulberry leaves. The composition has the effects of mainly supplementing vital energy and nourishing yin, invigorating spleen and activating thin fluid, and auxiliarily clearing away heat, eliminating damp and invigorating blood circulation to ensure that the spleen diseases are treated parallelly. The composition not only regulates the symptom of local yin deficiency and dryness heat, in particular foundation of spleen weakness, and ensures that the essence of foods can be absorbed by internal organs of the body to nourish all the limbs and bones, saliva is generated by self, strength is strengthened by self, and the recovery of patients with dispersion-thirst disease (diabetes) is promoted. Animal experiments prove that the Chinese medicinal composition can reduce the value of blood sugar of a rat with the diabetes, improve the carbohydrate tolerance of the rat with the diabetes caused by tetraoxypyrimidine, and has no obvious influence on the blood sugar of a normal mouse.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of blood sugar regulation and preparation method thereof, belong to field of Chinese herbal medicine technology.The present invention can be prepared into health food or medicine, mainly is applicable to hyperglycemia and diabetics crowd.
Background technology
Diabetes are commonly encountered diseases and frequently-occurring diseases of serious harm human health, and the sickness rate of developed countries is 5% according to the literature, and domestic sickness rate is 1%, and whole world diabetics surpasses 100,000,000 people already.Although because the application of antibiotics and the appearance of insulin, diabetics is died from infection and the ketoacidosis person greatly reduces, but cardio cerebrovascular affection easily takes place in diabetes, arteriosclerotic incidence rate can reach 90%, and diabetic neuropathic pathological changes, retinopathy, nephropathy become, and human beings'health and life are constituted increasing threat.Because growth in the living standard, onset diabetes rate present the trend that increases year by year, thereby many medical circle knowledgeable people point out that the control of diabetes has been task too impatient to wait.Except necessary medicine, improve diabetics dietary structure, the diabetic diet with therapeuticing and health effect is provided, in diabetes control, have crucial meaning.Very lack this type of diet in the market, utilization China natural plants is developed into has the urgent needs that the beverage of preventing and treating the diabetes effect has adapted to extensive patients just.
Diabetes spp traditional Chinese medical science diabetes, with thirsty polydipsia, rapid digestion of food is easily hungry, frequent micturition and sweet, emaciated physique, fatigue and asthenia is a Clinical symptoms, previously address primary disease traditional Chinese medical science pathology pathogenesis person, opinion pathological changes internal organs are blamed with lung more, stomach, kidney, the opinion pathogenesis is then summarized it with " deficiency of YIN is scorching ", the opinion treatment then specially overweights replenishing YIN and removing heat, yet, diabetes (diabetes) drinking-water does not understand repeatedly that it is thirsty, the water of being drunk instead directly becomes the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and is that urine is frequent, the rapid digestion of food polyphagia is not a skin, the little essence of diet leaks and body is day by day become thin, and the morbidity of quenching one's thirst is how relevant with the body constitution obesity, my phlegm-damp of fertile people, the body of the plain Sheng of phlegm-damp is easily suffered from the disease of " deficiency of YIN is scorching ", the pathological phenomenon list of this contradiction is seen with " deficiency of YIN is scorching " pathogenesis and is difficult to explain, still the basic pathological change of thinking diabetes be that the transfer function of spleen is not normal and cause the defeated cloth of water paddy body fluid and imbalance and the state of metabolic utilized, although this has just caused the diet that super quantity is arranged to take in the body but can not normally utilize for human body, show as some position of body and show " deficiency of YIN is scorching ", water Tianjin is not enough or lose symptom in nutrition, and have big water gaging paddy Tianjin miniflow to lose simultaneously in external, so " card of quenching one's thirst; Gu has the branch of upper, middle and lower, during its card all arises from Jiao and the utmost point in about " (" Records of Tradition Chinese and Western Medicine in Combination ").In burnt dysfunction of the spleen in transportation can not fail Tianjin and reach the then thirsty and polydipsia of lung, water Tianjin directly become the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and urinate frequently many, can not for stomach Xingqi body fluid then polyphagia become thin on the contrary, can not the nutrition kidney essense and kidney essense day loses.That levies is clinical, and the insufficiency of the spleen symptom of diabetes rather more sees, and the thirsty drink of quenching one's thirst is immoderate, must internal ulceration in spleen, single from " deficiency of YIN is scorching " pathogenesis, that abuse is grown is greasy cold and cool, the spleen fortune that more stagnates, and must aggravate disease.
Chinese medicine has accumulated very rich experience aspect treating diabetes, also put down in writing the natural plants of preventing and treating diabetes in a large number in the successive dynasties book on Chinese herbal medicine, and to preventing and treating the complication of diabetes, carrying out aspects such as Diet Therapy also has very abundant record.The present invention analyzes through more clinical data just, by to the discussion of the pathology of quenching one's thirst, method, side, medicine and the research of modern Chinese medicine pharmacology, adopts the also product of polyphagia with emaciation medicine to develop.
Summary of the invention
The object of the present invention is to provide Chinese medicine composition of a kind of blood sugar regulation and preparation method thereof.
The rule of treatment of the present invention is supplementing QI and nourishing YIN, spleen invigorating fortune Tianjin, is intended to correct the unbalanced state of diet water paddy body fluid in defeated cloth utilization and metabolic process, and dry thirsty symptom is eliminated.Based on supplementing QI and nourishing YIN, spleen invigorating fortune Tianjin, be equipped with heat clearing away, removing dampness, all medicines of invigorating blood circulation, adopt the product of also polyphagia with emaciation medicine to form the invention prescription, make and control all diseases of spleen and be not mutually exclusive, both regulated the scorching card of the local deficiency of YIN, it is strong basic that outstanding heavy spleen loses fortune, makes the precise and tiny logical the five internal organs of diet, reaches six internal organs, the extremity bones of the body collectively all gets it and supports, Tianjin is spontaneous, and power is improved oneself, and promotes diabetes (diabetes) rehabilitation of patients.The Herb Gynostemmae Pentaphylli bitter in the mouth is cold in nature in the side, the effect of eliminating inflammation and expelling toxin is arranged, eliminating the phlegm; Main chemical compositions is a gypenoside; The pharmacological action of defying age, resisting fatigue, blood sugar lowering, blood fat reducing is arranged.Rhizoma Dioscoreae, sweet in the mouth is flat, but merit spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating and essence nourishing, cure mainly quench one's thirst, diarrhea due to hypofunction of the spleen, cough due to consumptive disease, frequent micturition etc." herbal classic " cloud: " main damaging the spleen and stomach, tonify deficiency removes cold and heat pathogen, invigorating the spleen and replenishing QI power, longue meat." " book on Chinese herbal medicine is looked for the truth " cloud: " this genus of Rhizoma Dioscoreae food, ancients call its invigorating the spleen and replenishing QI heat extraction with going into decoction, though right gas is warm and flat, are the moon of spleen reinforcing lung, are can moisten fur, longue meat." pharmacological action is mainly reflected in regulating action, blood sugar lowering and the anti-aging effects to digestive system.Fructus Crataegi, sour in the mouth, sweet, slightly warm in nature, but merit promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis." daily book on Chinese herbal medicine " cloud: " relieving dyspepsia is long-pending, the row stagnation of QI, and it is wide every, the blood mass at the hypochondrium that disappears piece to be good for the stomach." " food mirror book on Chinese herbal medicine " cloud its " change clot, air parcel are invigorated blood circulation ".Fructus Mume, sour in the mouth is flat, and the function convergence is promoted the production of body fluid, and can control cards such as deficiency-heat excessive thirst, chronic cough, chronic diarrhea." herbal classic " calls its " the heat extraction stuffy sensation with restlessness is felt at ease ", supplement to the Herbal cloud its " remove expectorant, main cruel miasma is quenched the thirst and transferred, and removes cold and hot dysentery, and emesis is contrary ", and " concise and to the point Ji crowd side " controls to quench one's thirst and fries in shallow oil soup with Fructus Mume and take.Fructus Mori, sweet in the mouth is cold in nature, function kidney tonifying, tonifying liver, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., grows liquid, cures mainly hepatic and renal YIN deficiency, quenches one's thirst, diseases such as constipation, order are dark, tinnitus.Tang Materia Medica cloud its " single food, main quenching one's thirst." " it is thirsty to control heat, spermatogenesis god, and small intestinal heat for amplification on Canon of Materia Medica." " Bencao Jingshu ": " Fructus Mori, sweet cold beneficial blood and heat extraction are the enrich blood medicine of tonifying YIN of removing heat from blood.Quench one's thirst owing to interior-heat, deficiency of body fluid promotes the production of body fluid so quench the thirst.The five internal organs all belong to the moon, and so tonifying YIN is sharp the five internal organs.The deficiency of YIN then vim and vigour in joint is obstructed, and blood promotes the production of body fluid full, and cloudy gas is long to be contained, and then not hungry and vim and vigour are from logical." Folium Mori, sweet-bitter flavor, cold in nature, the effect of expelling wind and clearing away heat, cooling blood for improving eyesight is arranged, cure mainly affection due to external wind and heat, dizzy headache, conjunctival congestion is thirsty, diseases such as cough due to lung-heat.The Meng numerous: " process and fry in shallow oil drink, quench the thirst, just like the tea method.”
The present invention's safety in clinical practice is good, does not find any untoward reaction.
The active component of Chinese medicine composition of the present invention is to be made up of following several material medicines at least: Herb Gynostemmae Pentaphylli, Fructus Crataegi, Rhizoma Dioscoreae, Fructus Mume, Fructus Mori, Folium Mori six plant medicinal material.
The proportion of composing of six kinds of medical materials is in its prescription:
Herb Gynostemmae Pentaphylli 75-90 part, Fructus Crataegi 75-90 part, Rhizoma Dioscoreae 115-130 part, Fructus Mume 75-90 part, Fructus Mori 75-90 part, Folium Mori 37.5-45 part
Its preferred proportion of forming umber is:
60 parts of Herb Gynostemmae Pentaphylli, 80 parts of Fructus Crataegis, 100 parts of Rhizoma Dioscoreaes, 80 parts of Fructus Mumes, 60 parts in Fructus Mori, 50 parts on Folium Mori
Or:
80 parts of Herb Gynostemmae Pentaphylli, 60 parts of Fructus Crataegis, 120 parts of Rhizoma Dioscoreaes, 60 parts of Fructus Mumes, 80 parts in Fructus Mori, 25 parts on Folium Mori
Or:
72 parts of Herb Gynostemmae Pentaphylli, 72 parts of Fructus Crataegis, 109 parts of Rhizoma Dioscoreaes, 72 parts of Fructus Mumes, 72 parts in Fructus Mori, 36 parts on Folium Mori
Preferably, the active component of Chinese medicine composition of the present invention is made by the following step:
1), get in the prescription six plant medicinal material and select respectively only, take by weighing by the prescription amount;
2), decoct with water twice, twice amount of water and be respectively 8-10 and doubly measure, decocting time is 1-3 hour for the first time, decocting time is 1-2 hour for the second time, twice decoction liquor merges, and filters, measuring relative density when being concentrated into 60 ℃ is the concentrated solution of 1.00-1.05;
3), in concentrated solution, add the ethanol of 80-97%, the limit edged stirs, and adjusts concentration of alcohol to 50-70%, fully precipitation is filtered, filtrate recycling ethanol is not to there being the alcohol flavor, measuring relative density when being concentrated into 60 ℃ is the thick paste of 1.25-1.30, promptly.
In addition: the prescription of Chinese medicine composition of the present invention can preferentially add one or more in intimate vegetable drug Radix Sophorae Flavescentis, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Radix Puerariae, Fructus Lycii, Semen Euryales, Poria, Semen Lablab Album, Fructus Gardeniae, the Semen Coicis on the basis of five kinds of medical materials; Add in intimate vegetable drug Radix Salviae Miltiorrhizae, Radix Ginseng, Radix Pseudostellariae, Radix Asparagi, Radix Rehmanniae, Rhizoma Atractylodis, Radix Ophiopogonis, Herba Eupatorii, the Rhizoma Anemarrhenae, Radix Rehmanniae Preparata, Rhizoma Fagopyri Dibotryis, Radix Rhodiolae, Radix Scrophulariae, Radix Polygoni Multiflori, the Herba Dendrobii any one or a few on can also basis in front, but the medical material sum should be above 14 kinds.
Chinese medicine composition of the present invention can preparation technology routinely be made regular dosage form, for example capsule, tablet, pill, granule, oral liquid, effervescent tablet or health beverage.
Effervescent tablet in the above-mentioned dosage form can be made by following preparation method:
1), get in the prescription six plant medicinal material and select respectively only, take by weighing by the prescription amount;
2), decoct with water twice, twice amount of water and be respectively 8-10 and doubly measure, decocting time is 1-3 hour for the first time, decocting time is 1-2 hour for the second time, twice decoction liquor merges, and filters, measuring relative density when being concentrated into 60 ℃ is the concentrated solution of 1.00-1.05;
3), in concentrated solution, add the ethanol of 80-97%, the limit edged stirs, and adjusts concentration of alcohol to 50-70%, fully precipitation is filtered, filtrate recycling ethanol is not to there being the alcohol flavor, measuring relative density when being concentrated into 60 ℃ is the thick paste of 1.25-1.30;
4), with the oven dry of the thick paste of step 3) gained, the powder that gets dry extract adds the adjuvant that pharmaceutically can receive and granulates, oven dry, add the essence seasoning after, tabletting, promptly.
Preferred effervescent tablet preparation method is:
One, extraction process
1), get in the prescription six plant medicinal material and select respectively only, take by weighing by the prescription amount;
2), decoct with water twice, twice amount of water and be respectively 8-10 and doubly measure, decocting time is 1-3 hour for the first time, decocting time is 1-2 hour for the second time, twice decoction liquor merges, and filters, measuring relative density when being concentrated into 60 ℃ is the concentrated solution of 1.00-1.05;
3), in concentrated solution, add the ethanol of 80-97%, the limit edged stirs, and adjusts concentration of alcohol to 50-70%, fully precipitation is filtered, filtrate recycling ethanol is not to there being the alcohol flavor, measuring relative density when being concentrated into 60 ℃ is the thick paste of 1.25-1.30;
4), with the oven dry of the thick paste of step 3) gained, the powder that gets dry extract, standby;
Two, preparation process:
5) the pharmaceutical formulation weight portion is: 9.13 parts of 4.6 parts of polyethylene glycol 6000s of 1.82 parts of essence of 33.3 parts of asparagine phenyalanine methyl esters of 45.5 parts of lactose of 54.5 parts of sodium bicarbonate of 100 parts of citric acids of step (4) gained dried cream powder
6) granulate: the soda acid composition is separately granulated, citric acid is pulverized, cross 80 mesh sieves, the dried cream powder that adds pharmaceutical formulation amount 1/2 weight portion is granulated according to a conventional method; Sodium bicarbonate, lactose are crossed 80 mesh sieves, add the asparagine phenyalanine methyl ester, and the dried cream powder that adds pharmaceutical formulation amount 1/2 weight portion is granulated according to a conventional method;
7) drying: the soda acid granule is dry respectively, and baking temperature is controlled at 50 ℃, and moisture Control is below 3%;
8) tabletting: step 7) gained dried particles is put in order with 18 mesh sieves, and essence is pulverized, and crosses 80 mesh sieves, and polyethylene glycol 6000 is pulverized, and crosses 120 mesh sieves, with tabletting behind the granule mixing, promptly.
The health-care effect evaluation result
The auxiliary hyperglycemic function assay of carrying out according to Hebei province's health inspection center shows: the Chinese medicine composition of the present invention that per os gives the normal mouse high dose shows after 45 days that the normal mouse fasting glucose is not had obvious influence; The result of the test that influences to streptozotocin diabetic mice fasting glucose shows, each fasting blood sugar of organizing mice raises before the test, the fasting glucose rising degree of dosage group is light in the Chinese medicine composition of the present invention, compares with the hyperglycemia model group, and difference has significance (P＜0.05); The result of the test that influences to streptozotocin diabetic mice carbohydrate tolerance shows, in the Chinese medicine composition of the present invention under the blood glucose curve of dosage group area compare obvious reduction with the hyperglycemia model group, difference has significance (P＜0.05).According to the regulation of " health food check and assessment technique standard " (version in 2003), judge that Chinese medicine composition of the present invention has auxiliary hyperglycemic function.
Result through the auxiliary hyperglycemic function human feeding trial that Affiliated Hospital of Hebei University carries out shows: adopt counter point between own control and group, 100 example examination trenchermans are divided into test-meal group and placebo group at random, viewing duration is former take the hypoglycemic medicine kind and dosage constant, 1 month test period.The result shows, Chinese medicine composition of the present invention can make type ii diabetes people's the fasting glucose 1.36 ± 2.02mmol/L (rate of descent 12.7%) that on average descends, fasting glucose obviously reduces (P＜0.01) before than test-meal behind the test-meal Chinese medicine composition of the present invention, and its reduction value and decline percentage rate and placebo group comparing difference be (P equal＜0.01) significantly; Post-prandial glycemia 2.42 ± the 3.29mmol/L (rate of descent 14.0%) that descends, 2 hours after the meal blood glucose after the Chinese medicine composition group of the present invention test-meal obviously reduce (P＜0.01), its decline percentage rate and placebo group comparing difference remarkable (P＜0.05) before than test-meal.According to the regulation of " health food check and assessment technique standard " (version in 2003), decidable Chinese medicine composition of the present invention has the auxiliary hyperglycemic effect.
Safe toxicity evaluation result
The acute toxicity test of carrying out according to Hebei province's health inspection center, Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test, 30 days feeding trials of rat, the result shows, all greater than 15000mg/kg.bw, this product belongs to non-poisonous material to Chinese medicine composition of the present invention to the maximum tolerated dose (MTD) of the large and small Mus of two kinds of sexes; Three mutagenicity tests are feminine gender as a result; 30 days every indexs of feeding trial of rat there is no unusually.
The safety results of the Chinese medicine composition human feeding trial of the present invention that carries out through Affiliated Hospital of Hebei University shows: Chinese medicine composition of the present invention is not to hyperglycemia examination trencherman routine blood test, routine urinalysis, just conventional index and blood parameters all have obvious influence.Do not observe allergy and other untoward reaction in the test-meal process.
Pharmacological action Chinese medicine composition health beverage of the present invention (name of an article: Jin Liwang) carried out following animal experiment to prove its curative effect:
The experimentation of Jin Liwang beverage hypoglycemic activity
Summary: purpose: the hypoglycemic activity of observing the Jin Liwang beverage.Method: set up the alloxan diabetes rats model, detect the blood sugar level of Jin Liwang beverage to normal and animal pattern.The result: the Jin Liwang beverage can reduce the blood glucose value of diabetes rat, improves the carbohydrate tolerance by diabetes rat due to the alloxan, and the blood glucose of normal mouse is not had obvious influence.Conclusion: the Jin Liwang beverage has hypoglycemic activity.
1 physical data
1.1 experiment purpose
Observe the blood sugar reducing function of Jin Liwang beverage.
1.2 be subjected to the reagent thing
The Jin Liwang beverage, filbert liquid is made by Herb Gynostemmae Pentaphylli, Fructus Crataegi, Fructus Mume etc., and Shijiazhuang Yiling Pharmaceutical Co., Ltd provides, and adult's dose every day is 350ml (containing crude drug amount 17.5g).
1.3 laboratory animal
The KM mice, cleaning level, male and female half and half, 18～22g, provide credit number by Hebei province's Experimental Animal Center: SCXK (Ji) 2003-1-003, male SD rat, body weight 200 ± 20g provides credit number by dimension tonneau China laboratory animal technology company limited: SCXK (capital) 2002-0003.Feedstuff is a full-valence pellet feed, and credit number is provided by Hebei province's Experimental Animal Center: SCXK (Ji) 2003-2-001 keeps competent drinking-water.Adaptability was raised 5 days.
1.4 main agents
Metformin, Nantong pharmacy head factory, lot number 990902; Alloxan: sigma company product; Glyburide: Chinese Xinyi pharmaceutical factory product; The glucose assays test kit is by the biological company limited production of Shanghai Rong Sheng.
1.5 key instrument
Accuchek Advantage II type blood glucose meter (Roche Holding Ag), high speed low temperature centrifugal machine (RC5C type, Beckman company).
2 methods
2.1 observe of the effect of Jin Liwang beverage to normal mouse blood sugar
Get 50 of mices, be divided into the normal control group at random, glyburide (5mg/kg) group and Jin Liwang beverage height, middle low dosage (1.5,3,6g/kg) are organized.The normal control group gives the equal-volume distilled water, all the other each treated animal gastric infusions every day 1 time, 7d continuously.1h after the last administration is from mouse orbit venous plexus measuring blood sugar of blood extracting value.
2.2 observe of the effect of Jin Liwang beverage to alloxan diabetes rats blood glucose
Alloxan is made into 2% concentration in facing with preceding with normal saline, and the rat of fasting 12h gives the alloxan lumbar injection by 200mg/kg, and (fasting 12h) gets blood and survey blood glucose behind the 72h, and all 〉=16.70mmol/L is a diabetes rat.Get 50 of diabetes model rats, be divided into the alloxan group at random, diformin tablet (0.2g/kg) group and the high, medium and low dosage of Jin Liwang beverage (1.5,3,6g/kg) are organized.Other establishes 10 of normal control groups.Each treated animal gastric infusion every day 1 time, 21d continuously.The normal control group gives the equal-volume distilled water.Respectively at 14d, 21d before the administration and after the administration, get blood by the tail vein and survey fasting glucose.
The glucose tolerance experiment: 21d carries out carbohydrate tolerance test behind the medicine, lumbar injection glucose 2gkg
-1, blood sugar level is measured in blood sampling after 1,2 hour.
2.3 statistical method
Adopt the SPSS statistical software, carry out One-Way ANOVA Dunnett and analyze, all data all adopt (x ± s) expression.
3 results
3.1 the Jin Liwang beverage is to the influence of normal mouse blood sugar effect
Jin Liwang beverage group, glyburide group fasting glucose and normal control group are than there are no significant difference.Show that the Jin Liwang beverage does not have influence to normal mouse blood sugar.The results are shown in Table 1.
Table 1 Jin Liwang is to the influence of normal mouse blood sugar
3.2 the Jin Liwang beverage is to the effect of alloxan diabetes rats blood glucose
Jin Liwang beverage high dose group, metformin group in tried 14,21 days with the model group ratio, blood glucose obviously descends (P＜0.05), in the Jin Liwang beverage dosage group in tried 21 days with model group ratio, blood glucose obviously descend (P＜0.05).Show that the Jin Liwang beverage can reduce blood glucose in diabetic rats due to the alloxan.The results are shown in Table 2.
Table 2 Jin Liwang is to the influence of alloxan diabetes rats blood glucose
Compare with matched group,
*P＜0.05. and model group be #P＜0.05 relatively
3.3 the Jin Liwang beverage is to the effect of alloxan diabetes rats carbohydrate tolerance
Sugar back 1,2 hour, Jin Liwang beverage height, middle dosage group, metformin group blood glucose are starkly lower than model group (P＜0.05).Show that the Jin Liwang beverage can reduce the carbohydrate tolerance of diabetes rat due to the alloxan.The results are shown in Table 3.
Table 3 Jin Liwang is to the influence of alloxan diabetes rats carbohydrate tolerance
Compare with matched group,
*P＜0.05. and model group be #p＜0.05 relatively
4 conclusions
The Jin Liwang beverage can obviously reduce the alloxan diabetes rats fasting blood glucose level, improves the carbohydrate tolerance by diabetes rat due to the alloxan.Normal mouse blood sugar there is not influence.
The specific embodiment
Following embodiment is used to illustrate the preparation of medicine of the present invention, but it can not constitute any restriction to scope of the present invention.
Embodiment 1:
For the ease of the application of Chinese medicine composition of the present invention, this Chinese medicine composition is prepared as effervescent tablet.
Prescription:
Herb Gynostemmae Pentaphylli 72g, Fructus Crataegi 72g, Rhizoma Dioscoreae 109g, Fructus Mume 72g, Fructus Mori 72g, Folium Mori 36g.
Preparation method:
(1) gets in the prescription six plant medicinal material and select respectively only, take by weighing in proportion;
(2) above medical material adds 9 times of water gagings decoctions twice of water, decocts 2 hours for the first time, decocts 1.5 hours for the second time, and twice decoction liquor merges, and filters, and the mensuration relative density is the concentrated solution of 1.00-1.05 when being evaporated to 60 ℃;
(3) with the ethanol that adds 95% in step (2) the gained concentrated solution, the limit edged stirs, and adjusts concentration of alcohol to 60%, leaves standstill precipitate with ethanol 48 hours, and alcohol deposit fluid reclaims ethanol to there not being the alcohol flavor, and measuring relative density when being evaporated to 60 ℃ is the thick paste of 1.25-1.30;
(4) with the thick paste drying of step 3) gained, get dried cream powder 54.4g, add citric acid 57.6g, granulate according to a conventional method; Other gets dried cream powder 54.4g, adds sodium bicarbonate 48g, and lactose 35g granulates behind the asparagine methyl ester 2g mixing; Granule is dried respectively, adds fragrant citrus essence 4.8g, Polyethylene Glycol 9.6g, and mixing is pressed into the disk of 2.5g/ sheet, promptly.
Embodiment 2:
For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as capsule.
Prescription:
Herb Gynostemmae Pentaphylli 60g, Fructus Crataegi 80g, Rhizoma Dioscoreae 100g, Fructus Mume 80g, Fructus Mori 60g, Folium Mori 50g
Preparation method:
(1) gets in the prescription six plant medicinal material and select respectively only, take by weighing in proportion;
(2) above medical material decocts with water twice, adds 8 times of water gagings for the first time and decocts 3 hours; Add for the second time 10 times of water gagings and decocted 1 hour, twice decoction liquor merges, and filters, and measuring relative density when being evaporated to 60 ℃ is the concentrated solution of 1.00-1.05;
(3) with the ethanol that adds 80% in step (2) the gained concentrated solution, the limit edged stirs, and adjusts concentration of alcohol to 50%, leaves standstill 24 hours, and alcohol deposit fluid reclaims ethanol to there not being the alcohol flavor, and measuring relative density when being evaporated to 60 ℃ is the thick paste of 1.25-1.30;
(4) with the thick paste drying of step 3) gained, add citric acid 51g, lactose 38g granulates behind the mixing, oven dry, and mixing incapsulates, promptly.
Embodiment 3:
For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as oral liquid.
Prescription:
Herb Gynostemmae Pentaphylli 80g, Fructus Crataegi 60g, Rhizoma Dioscoreae 120g, Fructus Mume 60g, Fructus Mori 80g, Folium Mori 25g.
Preparation method:
(1) gets in the prescription six plant medicinal material and select respectively only, take by weighing in proportion;
(2) above medical material decocts with water twice, adds 10 times of water gagings for the first time and decocts 2 hours, adds 8 times of water gagings for the second time and decocts 1 hour, and twice decoction liquor merges, and filters, and measuring relative density when being evaporated to 60 ℃ is the concentrated solution of 1.00-1.05;
(3) with the ethanol that adds 97% in step (2) the gained concentrated solution, the limit edged stirs, and adjusts concentration of alcohol to 70%, leaves standstill 72 hours, and alcohol deposit fluid reclaims ethanol to there not being the alcohol flavor;
(4) with the alcohol deposit fluid of step 3) gained, add citric acid 6.1g, lactose 4.2g, honey peach essence 5.4g mixing is reconciled concentration, bottling, promptly.
Embodiment 4:
For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as effervescent tablet.
Prescription:
Herb Gynostemmae Pentaphylli 72g, Fructus Crataegi 72g, Rhizoma Dioscoreae 109g, Fructus Mume 72g, Fructus Mori 72g, Folium Mori 36g, Radix Sophorae Flavescentis 72g
Preparation method:
(1) gets in the prescription seven plant medicinal material and select respectively only, take by weighing in proportion;
(2) above medical material adds 9 times of water gagings decoctions twice of water, decocts 2 hours for the first time, decocts 1.5 hours for the second time, and twice decoction liquor merges, and filters, and the mensuration relative density is the concentrated solution of 1.00-1.05 when being evaporated to 60 ℃;
(3) with the ethanol that adds 95% in step (2) the gained concentrated solution, the limit edged stirs, and adjusts concentration of alcohol to 60%, leaves standstill precipitate with ethanol 48 hours, and alcohol deposit fluid reclaims ethanol to there not being the alcohol flavor, and measuring relative density when being evaporated to 60 ℃ is the thick paste of 1.25-1.30;
(4) with the thick paste drying of step 3) gained, get dried cream powder 55.1g, add citric acid 55g, granulate according to a conventional method; Other gets dried cream powder 55.1g, sodium bicarbonate 49g, and lactose 35g granulates behind the asparagine methyl ester 2.2g mixing, and granule is dried respectively, adds fragrant citrus essence 4.8g, Polyethylene Glycol 9.6g, mixing is pressed into the disk of 2.5g/ sheet, promptly.
Embodiment 5:
For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as health beverage.
Prescription:
Herb Gynostemmae Pentaphylli 72.5g, Fructus Crataegi 72.5g, Rhizoma Dioscoreae 109g, Fructus Mume 72.5g, Fructus Mori 72.5g, Folium Mori 36.5g,
Preparation method:
(1) gets in the prescription seven plant medicinal material and select respectively only, take by weighing in proportion;
(2) above medical material adds 9 times of water gagings of water and decocts twice, decocts 2 hours for the first time, decocts 1.5 hours for the second time, and twice decoction liquor merges, and filters, and filters, and is concentrated into to be equivalent to every 1ml filtrate and to contain vegetable drug 0.8-1.2g;
(3) with the ethanol that adds 95% in step (2) the gained concentrated solution, the limit edged stirs, and adjusts concentration of alcohol to 70%, leaves standstill precipitate with ethanol 48 hours, and alcohol deposit fluid reclaims ethanol to there not being the alcohol flavor;
(4) filtrate of step 3) gained is adjusted to distilled water is equivalent to every 1ml and contains vegetable drug 0.05-0.1g, fill becomes beverage according to a conventional method, promptly.
Embodiment 6:
For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as granule.
Prescription: Herb Gynostemmae Pentaphylli 72g, Fructus Crataegi 72g, Rhizoma Dioscoreae 109g, Fructus Mume 72g, Fructus Mori 72g, Folium Mori 36g, Radix Sophorae Flavescentis 72g, Rhizoma Polygonati Odorati 36g, Rhizoma Polygonati 36g, Radix Puerariae 36g, Fructus Lycii 36g, Semen Coicis 36g, Radix Ginseng 36g, Radix Rhodiolae 36g
Preparation method: formulation method is made granule routinely, promptly.
Embodiment 7:
For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as granule.
Prescription: Herb Gynostemmae Pentaphylli 72g, Fructus Crataegi 72g, Rhizoma Dioscoreae 109g, Fructus Mume 72g, Fructus Mori 72g, Folium Mori 36g, Radix Sophorae Flavescentis 72g, Rhizoma Polygonati Odorati 36g, Radix Polygoni Multiflori 36g, Radix Puerariae 36g, Fructus Lycii 36g, Semen Coicis 36g, Radix Ginseng 36g, Radix Rhodiolae 36g
Preparation method: formulation method is made pill routinely, promptly.
Claims (11)
1, a kind of health food of blood sugar regulation is characterized in that its main activated feedstock medical material comprises Herb Gynostemmae Pentaphylli, Fructus Crataegi, Rhizoma Dioscoreae, Fructus Mume, Fructus Mori, Folium Mori six plant medicinal material at least.
2, health food as claimed in claim 1, the part by weight of activated feedstock medical material is described in its prescription:
Herb Gynostemmae Pentaphylli 60-80 part, Fructus Crataegi 60-80 part, Rhizoma Dioscoreae 100-120 part,
Fructus Mume 60-80 part, Fructus Mori 60-80 part, Folium Mori 25-50 part
3, the described health food of claim 2, the part by weight of activated feedstock medical material is described in its prescription:
60 parts of Herb Gynostemmae Pentaphylli, 80 parts of Fructus Crataegis, 100 parts of Rhizoma Dioscoreaes,
80 parts of Fructus Mumes, 60 parts in Fructus Mori, 50 parts on Folium Mori
4, the described health food of claim 2, the part by weight of activated feedstock medical material is described in its prescription:
80 parts of Herb Gynostemmae Pentaphylli, 60 parts of Fructus Crataegis, 120 parts of Rhizoma Dioscoreaes,
60 parts of Fructus Mumes, 80 parts in Fructus Mori, 25 parts on Folium Mori
5, the described health food of claim 2, the part by weight of activated feedstock medical material is described in its prescription:
72 parts of Herb Gynostemmae Pentaphylli, 72 parts of Fructus Crataegis, 109 parts of Rhizoma Dioscoreaes,
72 parts of Fructus Mumes, 72 parts in Fructus Mori, 36 parts on Folium Mori
6, the active component of the arbitrary described health food of claim 2-5 is made by the following step:
1), get that the activated feedstock medical material selects respectively only in the prescription, take by weighing by the prescription amount;
2), decoct with water twice, twice amount of water and be respectively 8-10 and doubly measure, decocting time is 1-3 hour for the first time, decocting time is 1-2 hour for the second time, twice decoction liquor merges, and filters, measuring relative density when being concentrated into 60 ℃ is the concentrated solution of 1.00-1.05;
3), in concentrated solution, add the ethanol of 80-97%, the limit edged stirs, and adjusts concentration of alcohol to 50-70%, fully precipitation is filtered, filtrate recycling ethanol is not to there being the alcohol flavor, measuring relative density when being concentrated into 60 ℃ is the thick paste of 1.25-1.30, promptly.
7, according to the described health food of claim 1-5, the preparation formulation that it is characterized in that this health food is capsule, tablet, pill, granule, oral liquid, effervescent tablet or health beverage.
8, according to the described health food of claim 1-5, on its prescription basis in adding vegetable drug Radix Salviae Miltiorrhizae, Radix Ginseng, Radix Pseudostellariae, Radix Asparagi, Radix Rehmanniae, Rhizoma Atractylodis, Radix Ophiopogonis, Herba Eupatorii, the Rhizoma Anemarrhenae, Radix Rehmanniae Preparata, Rhizoma Fagopyri Dibotryis, Radix Rhodiolae, Radix Scrophulariae, Radix Polygoni Multiflori, Herba Dendrobii, the Radix Sophorae Flavescentis any one or a few, and make prescription medical material total quantity be no more than 14 kinds.
9, health food as claimed in claim 1 adds the vegetable drug Radix Sophorae Flavescentis on the basis of its prescription.
10,, it is characterized in that forming by following steps according to the preparation method of the described health food effervescent tablet of claim 7:
1), get that activated feedstock medical material medical material selects respectively only in the prescription, take by weighing by the prescription amount;
2), decoct with water twice, twice amount of water and be respectively 8-10 and doubly measure, decocting time is 1-3 hour for the first time, decocting time is 1-2 hour for the second time, twice decoction liquor merges, and filters, measuring relative density when being concentrated into 60 ℃ is the concentrated solution of 1.00-1.05;
3), in concentrated solution, add the ethanol of 80-97%, the limit edged stirs, and adjusts concentration of alcohol to 50-70%, fully precipitation is filtered, filtrate recycling ethanol is not to there being the alcohol flavor, measuring relative density when being concentrated into 60 ℃ is the thick paste of 1.25-1.30;
4), with the oven dry of the thick paste of step 3) gained, the powder that gets dry extract adds the adjuvant that pharmaceutically can receive and granulates, oven dry, add the essence seasoning after, tabletting, promptly.
11,, it is characterized in that the preparation process of step 4) is according to the preparation method of the described health food effervescent tablet of claim 10:
1) the pharmaceutical formulation weight portion is: 100 parts of claim 10 step 4) gained dried cream powders
33.3 parts of 45.5 parts of lactose of 54.5 parts of sodium bicarbonate of citric acid
9.13 parts of 4.6 parts of polyethylene glycol 6000s of 1.82 parts of essence of asparagine phenyalanine methyl ester
2) granulate: the soda acid composition is separately granulated, citric acid is pulverized, cross 80 mesh sieves, add the dried cream powder of pharmaceutical formulation amount 1/2 weight portion, granulate according to a conventional method; Sodium bicarbonate, lactose are crossed 80 mesh sieves, add the asparagine phenyalanine methyl ester, add the dried cream powder of pharmaceutical formulation amount 1/2 weight portion, granulate according to a conventional method;
3) drying: the soda acid granule is dry respectively, and baking temperature is controlled at 50 ℃, and moisture Control is below 3%;
4) tabletting: step 3) gained dried particles is put in order with 18 mesh sieves, and essence is pulverized, and crosses 80 mesh sieves, and polyethylene glycol 6000 is pulverized, and crosses 120 mesh sieves, with tabletting behind the granule mixing, promptly.
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