CN103041070B

CN103041070B - Lipid-lowering and pressure-releasing folium ginkgo health-care product and preparation method thereof

Info

Publication number: CN103041070B
Application number: CN201210585308.8A
Authority: CN
Inventors: 毕博学; 于新梅; 栾桂霞; 匡素清
Original assignee: Qingdao Huaren Technology Incubator Co Ltd
Current assignee: Shenzhen City Yi Restaurant Food Co. Ltd.
Priority date: 2012-12-31
Filing date: 2012-12-31
Publication date: 2014-11-05
Anticipated expiration: 2032-12-31
Also published as: CN103041070A

Abstract

The invention provides a lipid-lowering and pressure-releasing folium ginkgo health-care product. The health-care product comprises the following raw materials in part by weight: 50-100 parts of folium ginkgo, 10-20 parts of fructus rubi, 10-20 parts of rehmannia glutinosa, 10-20 parts of Chinese angelica, 10-20 parts of dogwood, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of poria cocos, 10-20 parts of dracocephalum heterophyllum benth, 10-20 parts of codonopsis pilosula, 10-20 parts of herba eupatorii, 10-20 parts of gynostemma pentaphylla, 10-20 parts of astragalus mongholicus, 10-20 parts of rhizoma alismatis, 10-20 parts of safflower carthamus, 10-20 parts of scutellaria baicalensis, 10-20 parts of radix paeoniae alba, 10-20 parts of gardenia, 10-20 parts of white atractylodes rhizome, 10-20 parts of glossy privet fruit, 10-20 parts of tartary buckwheat and 10-20 parts of propolis. According to the invention, as the folium ginkgo is extracted, the active ingredients of the folium ginkgo are retained, and the toxicity is reduced; and as the traditional Chinese medicinal materials, which can activate blood and remove stasis and can obviously reduce the blood sugar and fat serum triglyceride, are added, the microcirculation can be improved, the immunity is enhanced, and people can accept easily, as a result, the lipid-lowering and pressure-releasing efficacy can be better achieved. According to the invention, the health-care product cannot be taken by pregnant women and young children.

Description

A kind of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product and preparation method thereof

Technical field

The present invention relates to contain the blood fat-reducing blood pressure-decreasing health product that derive from plant composition, particularly a kind of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product and preparation method thereof.

Background technology

Folium Ginkgo is a kind of plant with very high medical value, and ginkgo is one of ancient seeds of China, and it is the tree of magical medical treatment, and before more than 200,000,000 5 thousand year, dinosaur is controlled terrestrial time Jurassic Period, and Semen Ginkgo is one of the most flouring plant.Life on earth is gone through the change of 100000000000 years, especially, after the glacier covering of the 4th century, only has Semen Ginkgo still to keep its most original looks, is called as " living fossil " in organic evolution history.Its leaf, fruit, seed have higher medical value, and its pharmacological action is constantly familiar with, and clinical application range progressively expands.Ginkgo has another name called maidenhair tree, is the rarity of China, rare valuable, is described as " hollywood lignumvitae ", " living fossil " of the earth.

In Folium Ginkgo, contain the multiple components useful with health such as natural activity flavone and amarolide, there is dissolving cholesterol, the effect of blood vessel dilating, has positive effect to improving disordered brain function, arteriosclerosis, hypertension, dizzy, tinnitus, headache, senile dementia, hypomnesis etc.Its diseases prevention, cure the disease, the value of body-building is early on the books in the < of Ming Dynasty's Li Shizhen (1518-1593 A.D.) < Compendium of Materia Medica > >.Through national health department, detect proof: drink Folium Ginkgo tea and can obviously reduce serum cholesterol, triglyceride and low-density blood lipoprotein, reduce the effect of depot lipid in body.For the complementary controls of diseases of cardiovascular and cerebrovascular systems patient such as adjusting, hypertension and coronary heart disease of hyperlipidemia and obese type crowd's fat-reducing etc., having good effect, is the desirable beverage of prophylactic treatment senile dementia.Be recognized in the worldly control, the optimal pharmaceutical compositions of anti-cardiovascular and cerebrovascular disease.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Though Folium Ginkgo energy blood circulation promoting, prevention cardiovascular diseases, but can not take other simultaneously and control cardiovascular drugs (for example aspirin), Semen Ginkgo extrac is concentrated granular shape, there is very strong removing free radical and antioxidation, the synthetic collagen Proteins of yellow glycoside, aminoacid and aminoacid in Folium Ginkgo is improved looks to human body, and check melanin growth, keeps skin gloss and elasticity to play no small effect.In addition, according to modern clinical research, to take the chronic schizophrenia that negative symptoms is main (as social withdrawal, sluggishness, the poverty of thought, the symptom such as dull), there is remarkable result, cerebellar atrophy (senile dementia) is also had to certain effect.

The high speed development of Modern Urban Living, also brings a series of affluenza.Wherein " three-hypers " and obesity are puzzlement people's primary enemies." three-hypers disease " refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia.Conventionally be accompanied by obesity.They are " affluenza " that modern society is derived from, and possible individualism also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipidemia simultaneously, and hyperlipidemia is the principal element of arteriosclerosis formation and development, the poor aggravation hypertension of arteriosclerotic's blood vessel elasticity, thus the later stage all formed " three-hypers disease ".About three-hypers, be what has statistics, in the Chinese ten large causes of death, the mortality rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three-hypers " also accounts for 27% of total death toll.Hyperlipidemia can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycemia can cause diabetes.World Health Organization (WHO) once clearly proposed, and prevented that cardiovascular diseases's the first line of defence from reducing exactly " three-hypers " and controlled " three-hypers ".A lot of diabetes patients are with hyperlipemia, so people call sister's disease diabetes and hyperlipemia conventionally, and think that hyperlipidemia is the secondary disease of diabetes.About 40% diabetic has disorders of lipid metabolism according to statistics.Being characterized in that triglyceride increases with high density lipoprotein reduces.Diabetes cause that the reason of Lipid increase is during due to diabetes patient's insufficient insulin, and body lactonase activity lowers, therefore easy Lipid increase.Diabetes itself also companion's fat, protein and water, dielectric disorder simultaneously except carbohydrate metabolism disturbance on the other hand.Often there is free fatty to mobilize out from fat depot, make triglyceride and free fatty Enrichment in blood.Type 2 diabetes mellitus people takes food too much on the one hand again, and motion is few, impels synthetic the increasing of the interior lipid of body, and this is also the reason that causes Lipid increase.And fat companion's hyperlipidemia person because Insulin receptor INSR number reduces relatively, thereby produces insulin resistant, easy induced Diabetic.Lipid increase person also easily causes the heart, cerebrovascular complication.

Folium Ginkgo is with other Chinese herbal medicine compatibility, can bring into play better its blood pressure lowering, blood fat reducing, fall the effect of hyperlipidemia.The effect of vegetable flavonoid in human body, mainly to strengthen antiotasis, coronary artery dilator, vessel softening, improve vascular permeability, reduce blood pressure, reduce blood fat and cholesterol, anti-platelet aggregation, minimizing thrombosis, reduce endovascular HDL-C (HDL-C), triglyceride (TG), thereby reach blood pressure lowering, blood fat reducing, fall the sticky effect of blood.Vegetable flavonoid is indispensable neccessary composition in human body, and Six-element flavone tea is rich in flavone, rutin.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting blood coagulation situation, not blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel, more can not long-term taking, in order to avoid cause cerebral hemorrhage.Folium Ginkgo can not together brew up with Folium Camelliae sinensis and Flos Chrysanthemi.

Although ginkgo Leaves health care effect is very strong, Folium Ginkgo, containing toxic component, brews up and can cause clonospasm, neural paralysis, platycoria, allergy and other side effect with it.Anemia of pregnant woman and child, old man is careful.In Folium Ginkgo, have a kind of composition ginkgoic acid, if the dosage of use is excessive, or Time of Administration is long, can damage heart.Semen Ginkgo contains a large amount of ginkgoic acids, ginkgoic acid is containing virose, the leaf of generally buying does not pass through deep processing and extraction, the ginkgoic acid content of the inside is up to 3000-4000ppm, special ginkgoic acid is water miscible, one soaked Semen Ginkgo pyrite and the active substance such as Semen Ginkgo lactone of not only not having the inside, effect is contrary on the contrary, the inside is poison entirely.

Although ginkgo Leaves health care effect is very strong, Folium Ginkgo, containing toxic component, brews up and can cause clonospasm, neural paralysis, platycoria, allergy and other side effect with it.Ginkgoic acid, improper use or dosage are too large, are easy to cause poisoning.So at present in the urgent need to a kind of technique, health-care effect that can application Folium Ginkgo, makes again its poisonous material drop to minimum.Anemia of pregnant woman and child, old man is careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting blood coagulation situation, not blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel, more can not long-term taking, in order to avoid cause cerebral hemorrhage.In Folium Ginkgo, have a kind of composition ginkgoic acid, if the dosage of use is excessive, or Time of Administration is long, can damage heart.

Summary of the invention

Technical problem to be solved by this invention is, prior art exists a lot of defects, and at present, blood fat reducing and atherosclerosis health product are more, differ from one another, but also have certain deficiency simultaneously, as higher in price, and patient is difficult to accept; Specific aim is not strong, and therapeutic effect is undesirable etc.; And Folium Ginkgo contains toxic component, with it, brewing up to cause clonospasm, neural paralysis, platycoria, allergy and other side effect; In Folium Ginkgo, have a kind of composition ginkgoic acid, if the dosage of use is excessive, or Time of Administration is long, can damage heart.The present invention extracts Folium Ginkgo, not only retained its beneficiating ingredient, reduce toxicity, add some blood circulation promoting and blood stasis dispelling, the Chinese crude drug that blood glucose and fatty serum triglycerides is all had to obvious reducing effect, can improve microcirculation, improve immunity and make people be easy to accept, more can reach preferably the effect of blood fat-reducing blood pressure-decreasing.

For solving the problems of the technologies described above, the invention provides a kind of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, in described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, the parts by weight of various raw materials are: 50～100 parts of Folium Ginkgos, 10～20 parts of Fructus Rubies, 10～20 parts, Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts, Poria, 10～20 parts of heterophyllum, 10～20 parts of Radix Codonopsis, 10～20 parts of Herba Eupatoriis, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Alismatis, 10～20 parts, Flos Carthami, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Gardeniaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of propolis.

Described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, described in it, in health product, the parts by weight of various raw materials can be preferably: 50～85 parts of Folium Ginkgos, 10～15 parts of Fructus Rubies, 10～15 parts, Radix Rehmanniae Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Corni, 10～150 parts of Radix Salviae Miltiorrhizaes, 10～15 parts, Poria, 10～15 parts of heterophyllum, 10～15 parts of Radix Codonopsis, 10～15 parts of Herba Eupatoriis, 10～15 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Alismatis, 10～20 parts, Flos Carthami, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Gardeniaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of propolis.

Described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, described in it, in health product, the parts by weight of various raw materials also can be preferably: 50～100 parts of Folium Ginkgos, 10～20 parts of Fructus Rubies, 10～20 parts, Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts, Poria, 10～20 parts of heterophyllum, 10～20 parts of Radix Codonopsis, 10～20 parts of Herba Eupatoriis, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Alismatis, 10～15 parts, Flos Carthami, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Gardeniaes, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～15 parts of propolis.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, and the preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product comprises the following steps:

A. Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. Folium Ginkgo extract sucking filtration;

D. Folium Ginkgo extract is condensed into particulate matter, powder or unguentum;

E. by the agent of surplus stock granulation, powder or unguentum;

F. pack after granule obtained above, powder or unguentum being mixed with the Folium Ginkgo extract of making.

In described step a, can get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, dry 8-12h, taking-up is placed in drying baker cooling, with pulverizer, pulverizes 60 mesh sieves, and powder is placed in brown wide mouthed bottle and stores.

In described step b, can get 640mL95% ethanol, 360mL pure water is made into 60% alcoholic solution; Then get 100g ginkgo leaf powder in 700mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, by filtered through gauze, in residue, add 60% ethanol 700mL, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.

In described step c, ginkgo biloba succi first can be used to gauze coarse filtration, remove bulky grain precipitation, to improve sucking filtration speed; Sucking filtration instrument is installed, in buchner funnel, is added a small amount of lixiviating solution to carry out sucking filtration, after sucking filtration finishes, get filtrate and abandon filtering residue.

In described steps d, distillation, concentrating appts can be installed, in sucking filtration liquid, containing a large amount of alcoholic solution, with distilling apparatus, carry out ethanol and be condensed into particulate matter or paste object.

In described step e, surplus stock can be put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, merges standing by 2 extracting solution; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged, and the filtrate of 1.36 o'clock when concentrating under reduced pressure relative density is 80 ℃, reclaims ethanol; gained filtrate is adjusted to proportion to 1.06, and the extractum that reduces pressure to obtain, puts into dehydrator and dries; then add dextrin and be in harmonious proportion, put into granulator and make 1-2 centimetre of granule.

In described step f, can mix by making the Folium Ginkgo extract that granule or powder make with above-mentioned steps in step 9 molding of pack packing.

Decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is fried, and not exclusively mouthfeel is poor, is not suitable for the Modern human populations medication custom.Because this aspect is mainly used in preventing and treating hyperlipemia, hyperglycemia, this disease belongs to multifactor relevant chronic disease, and the course of disease is longer, needs long-term prescription just can reach good effect, therefore should select to take, carry, health product easy to use.The features such as health product have the bad smell of covering, attractive in appearance, to be easy to swallow, and technique is simple, and onset is rapid, is applicable to long-term taking, can not damage health.The invention solves the virose shortcoming of Folium Ginkgo; And the beneficiating ingredient that has retained greatly Folium Ginkgo, makes it not have work in-process to run off, and has on the make avoided secondary pollution, is the health product of green health environmental protection completely.Add some blood circulation promoting and blood stasis dispelling, reduce the Chinese crude drug that blood glucose and Triglycerides in Serum all have obvious effect, can improve microcirculation, improve immunity.And the most mouthfeel of these medical materials is light, make people be easy to accept, more can reach preferably the effect of blood fat-reducing blood pressure-decreasing.

The specific embodiment

In Folium Ginkgo, the Mineral Concentrations such as VC, VE, carotene and calcium, phosphorus, boron, selenium is also very abundant, surpasses general fruit and vegetable and edible plant raw material.Biological anti-oxidant is a class material directly and indirectly in body with anti-oxidation function.In Folium Ginkgo, contain two class antioxidants--nutrient antioxidant and non-nutritive antioxidant.The former mainly contains carotene, VC, VE, selenium, zinc, copper etc.; the latter mainly contains ginkgetin, terpene lactones, catechin, Polyphenols etc.; content is also very abundant, and they are not subject to have ten important effects aspect the oxidative damage due to free radical at protection body.Therefore, Folium Ginkgo integrates nutrition, health care, treatment function, and using Folium Ginkgo as high nutrition, the resource that is worth of health care developed, this is significant for improving Folium Ginkgo comprehensive utilization ratio.The exploitation of Folium Ginkgo are from the thirties in 20th century, and Japan and West Germany have started the research of Folium Ginkgo.Along with deepening continuously of modern pharmacological research, to find not only to contain Flavonoid substances in Folium Ginkgo, and also have the compounds such as terpene lactones, phenols, the pharmacological action of their brilliances is familiar with gradually by people.Clinical observation proves, Folium Ginkgo has several effects below: 1, reduce cholesterol levels in blood of human body, prevent arteriosclerosis.To being short of physical strength after middle-aged and elderly people light activity, palpitating speed, chest pain, the effect of being significantly improved such as feel dizzy.2, by increasing the saturating property of blood vessel and elasticity, reduce blood pressure, have good antihypertensive effect.3, eliminate the deposition composition in blood vessel wall, improve blood flow and change, promote erythrocyte deformability, reduce blood viscosity, make blood flow unobstructed, can prevent and treat cerebral hemorrhage and cerebral infarction.The senile dementia that arteriosclerosis is caused also has certain curative effect.Gingko leaf preparation and antidiabetic drug share treatment diabetes good therapeutic effect, can be used for the adjuvant of diabetes.5, can obviously alleviate the symptoms such as abdominal pain in menstruation and sore waist and aching in the waist and the back.6, for the treatment of bronchial asthma, also there is good therapeutic effect.7, reduce level of lipid, reduce freckle, moist skin, beautiful appearance.8, relieving constipation, diuresis, toxin expelling, removing toxic substances.9, climacteric syndrome is improved significantly.

Folium Ginkgo has formation, the reduction serum fat that suppresses fatty liver and the effect that suppresses atherogenesis.Active component comprises DNJ, plant sterol, flavonoid etc.The flavones ingredient that contains strengthening blood capillary, reduction blood viscosity in Folium Ginkgo, Folium Mori product contain the composition of LDL-lipoprotein oxidation in antibody in addition, so Folium Ginkgo, when fat-reducing, improving hyperlipemia, has again the effect of prevention myocardial infarction and cerebral hemorrhage.Hyperlipemia serum lipids is raise Folium Ginkgo extract and atherosclerosis has inhibitory action.Find that after deliberation Folium Ginkgo product can make hyperlipidemia rats serum high-density LP (HDL-C), HDL-CTC obviously raise (p < 0.05), T-CHOL (TC), LDL-C, triacylglycerol (TG) obviously reduce (p < 0.05), lipid peroxide (LPO) significantly reduces (p < 0.001), illustrate that Folium Ginkgo can reduce blood fat, vessel softening, removing body endoperoxide, thereby the rising of hyperlipemia serum lipids and atherosclerosis are had to inhibitory action.But anemia of pregnant woman of the present invention and child, old man is careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting blood coagulation situation, not blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel, more can not long-term taking, in order to avoid cause cerebral hemorrhage.In Folium Ginkgo, have a kind of composition ginkgoic acid, if the dosage of use is excessive, or Time of Administration is long, can damage heart.

Fructus Rubi is warm in nature; Sweet, sour; Return kidney, urinary bladder channel.Cure mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.< < Bencao Jingshu > >: " Fructus Rubi, its main QI invigorating person, says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, and body, from light, is sent out in vain not also.The respectful main tonify deficiency of reviving is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.The main man's kidney-jing deficiency of Zhen Quan exhausts, impotence, woman's food have a son.Large bright main settling five organs, beneficial color, supports vital essence, long hair, strong will.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence." < < property of medicine opinion > > carries it: " main man's kidney-jing deficiency exhausts, woman's food have a son.Main impotence.

Fructus Corni, cures mainly pathogen cold and heat under the heart, and warming middle-JIAO, by cold warm numbness, goes three worms, the merit that for a long time clothes have been made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stopped dribbling urination; Take for a long time improving eyesight, brute force all the year round.Fructus Corni, has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is the conventional rare Chinese medicine of China, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties use that medical science is liked.Zhang Zhongjing be take Fructus Corni and has been formulated " JINGUI SHENQI WAN " as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin that physiologically active is stronger, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is Herba indigoferae Pseudotinctoriae conventional in tcm clinical practice.

Radix Et Rhizoma Fagopyri Tatarici is the medicine-food two-purpose crop that occurring in nature is very few, according to < < Compendium of Materia Medica > >, records: Radix Et Rhizoma Fagopyri Tatarici bitter in the mouth, and property is flat cold, the real the intestines and stomach of energy, physical strength profiting, continuous spirit, profit knowledge, refining the five internal organs slag is dirty; All on the books to Radix Et Rhizoma Fagopyri Tatarici in < < Qianjin Yao Fang > >, < < Chinese medicine voluminous dictionary > > and pertinent literature: can calm the nerves, the swollen wind pain of lively atmosphere blood, the wide intestinal of sending down the abnormal ascending QI, heat clearing away, long-pendingization of dispelling are stagnant, bowel relieving, intestine moistening, relieving constipation, cough-relieving, relieving asthma, the effect such as antiinflammatory, antiallergic, heart tonifying, fat-reducing, beauty treatment.Radix Et Rhizoma Fagopyri Tatarici--seven major nutrient complete set, is not medicine, is not health product, is to work as the food that meal is eaten, and but has remarkable healthy nutritive value and outstanding dietetic therapy effect.It does not belong to grass family, and belongs to Polygonaceae, and " Radix Polygoni Multiflori, the Radix Et Rhizoma Rhei " be familiar with people etc. is blood brother, is the outstanding grain medicine dual-purpose grain kind that international food and agricultural organization generally acknowledges, is typical case's embodiment of China's integration of edible and medicinal herbs culture.Radix Et Rhizoma Fagopyri Tatarici is described as " kings of grain rice ", and three fall food (blood pressure lowering, blood sugar lowering, blood fat reducing).Produce in high and cold mountain area, Southwest China and Shanxi north one band, green natural, pure nothing is dyed, and because of place of production difference nutritive value difference.Radix Et Rhizoma Fagopyri Tatarici has uniqueness, comprehensive, abundant nutrition, and medicinal characteristic is good, has the necessary multiple nutrients composition of human body, so be described as the mankind " natural gold partner " by world's nutritionist.Radix Et Rhizoma Fagopyri Tatarici energy anti-inflammation, has the laudatory title of " antiinflammatory grain ".

Fructus Ligustri Lucidi is for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, often joins the same use of Fructus Mori, and fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, the hepatic injury of Carbon Tetrachloride Induced being had to obvious protective effect, and can promote liver cell regeneration. oleanolic acid also can make in liver triglyceride accumulate that minimizings, hepatocellular degeneration necrosis obviously alleviate, glycogen is accumulated increase, serum γglobulin decline; Mitochondrial swelling and the degeneration of endoplasmic reticulum vesicle alleviates, the inflammatory reaction of hepatic tissue interstitial weakens in the visible hepatocyte of ultrastructure.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Fructus Gardeniae is the fruit of Fructus Gardeniae tree, is Chinese medicine.The l that belongs to Ministry of Public Health promulgation criticizes medicine-food two-purpose resource, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in treating the diseases such as icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly three warmers pathogenic heat, and the conjunctival congestion and swelling pain of attacking on can treating the liver gallbladder burning hot, often joins Radix Et Rhizoma Rhei use, as Fructus Gardeniae soup < < Shengji Zonglu > >.

Radix Codonopsis is the conventional traditional tonic of China, take Radix Codonopsis that area, Shangdang, Shanxi produces ancient times as top grade, has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition leukopenia chemotherapy radiotherapy being caused has castering action.Radix Codonopsis has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc.< < Bencao Congxin > > records: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than middle feeble QI, in order to adjust, mend, very smooth and proper.”

Herb Gynostemmae Pentaphylli is found through modern medicine study, the main effective ingredient of Herb Gynostemmae Pentaphylli is polysaccharide, flavonoid, saponins and microelement kind, its effect is mainly to promote body fat class substance metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in treatment and the health care of hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, chronic respiratory inflammation (pharyngolaryngitis, gastroenteritis etc.).

Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, reaches by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels due to insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Herba Eupatorii expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience heat-damp in summer; Cold and heat headache; In moistening, accumulate; Gastral cavity painful abdominal mass is not hungry; Nausea and vomiting; Sweet greasy in mouthful; Disappear truly. < < Bencao Jingshu > >: lung governing qi, lung qi pent-up, upper orifices is closed and lower orifices are obstructed, the main Na Shuigu of stomach, stagnation of stomach-QI, when water paddy not take, be accumulation of phlegm in the hypochondrium, the pungent flat energy eliminating stagnation of Herba Chlorophyti is stagnant, and fragrance can be disliked by dirt eliminating, come up all cards from recover, mostly appetizing removes and dislikes, lung heat clearing expectorant, and the panacea of Disperse hepatic depression is also.< < key medicine is divided agent > >: Herba Chlorophyti, for the product of expectorant except the Yu Xiejie that dislikes, falls apart, through the > > treating with Herba EuPatorii of quenching one's thirst, removing the accumulation of stale pathogen also in < <.Lid is quenched one's thirst by pathogenic heat pent-up in stomach, blue can removing the accumulation of stale pathogen.Known Herba Chlorophyti admittedly be take and cleanses as merit, eliminates the intestines and stomach person also.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also there is remarkable inhibitory action.< < property of medicine opinion > > carries it: monarch, and sweet in the mouth, pungent, nontoxic.Can main large migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out under only.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.< < detailed outline > > carries: Radix Salviae Miltiorrhizae, press the sensible opinion of < < married woman > > cloud, SIWU TANG is controlled gynecopathy, pay no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls, stops metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

Rhizoma Alismatis (rhizome) is one of traditional Chinese medicine.Theory of Chinese medical science thinks that it is cold in nature, has the effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.The fat-soluble part of Rhizoma Alismatis has obvious cholesterol reducing effect and study of anti-atherogenic effect to experimental hypercholesterolemicrabbits rabbit, by wherein separated Alisol A, B and Alisol A, the acetas of B, C, except alisol B, there is the cholesterol reducing effect showing.Content with 0.1% adds in the feedstuff of experimental atherosclerosis rats, can make cholesterolemia decline more than 50%, wherein the strongest with the effect of Alisol A-24-acetas.The ethanol extraction of Rhizoma Alismatis, the ethyl acetate extract of ethanol extract etc., have effect for reducing blood fat to experimental hypercholesterolemicrabbits rabbit and rat.Ethyl acetate extract and its residual fraction effect being insoluble in acetic acid one water are the strongest.Ethyl acetate extract oral 1g/kg every day, also has obvious cholesterol reducing effect to the normal rat of raising with normal diet.By coordination list notation method, prove, Alisol A has the ability that suppresses mouse small intestine esterified cholesterol, and can make the absorbance of cholesterol in rat small intestine reduce by 34%, but does not affect linoleic absorption.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The medicinal history of existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, food stagnation is stagnated, carbuncle from the beginning of or burst after the excess syndrome such as pyretic toxicity Shang Sheng.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.< < herbal classic > > records: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." < < Japan hanako materia medica > > record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”

Propolis (bee glue) have the good reputation of " blood vessel street cleaner ", the large quantity research that recent domestic scholar does shows, flavonoid in propolis (flavonoid) composition and various active composition, can improve elasticity and the permeability of blood vessel, vasodilator, removes the overstocked thing of depositing of blood vessel, purify the blood, reduce blood fat, reduce blood viscosity, improve and organize microcirculating state, and the effect that there is stronger antioxidation, removes free radical.Toxicological experiment result shows that propolis is actual innocuous substance, and therefore by long-term taking propolis, being prevented and treated hyperlipemia is safe and feasible.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood.< < Japan hanako materia medica > >: control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, logical month water, brings down a fever, relieving restlessness, QI invigorating, the hot disease of it row, pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Flos Carthami promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Promoting blood circulation to restore menstrual flow medicine.Flos Carthami decoct, Carthamus yellow and other preparations all have rapid depressurization effect in various degree to anesthetized cat or dog, and mean blood pressure declines about 20 mm Hg, continue to recover after approximately 30 minutes.. < < book on Chinese herbal medicine converges says > >: Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood is also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth do not fall, dead fetus in the uterus, is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood chamber, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, are cards of disharmony between QI and blood all, and non-Flos Carthami can not be adjusted.

Heterophyllum, plants latin name: Dracocephalum heterophyllum Benth.All herbal medicine.Cure mainly clearing away lung-heat to relieve cough, promoting the function of the gallbladder to alleviate jaundice, cool liver endogenous wind stopping, hard masses softening and resolving.Control hypertension, lymphadenitis, cough due to lung-heat.Good depressor.

Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, there is the YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, the disease such as pass out semen, quench one's thirst, is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.This quality is moistened into kidney, kind nourishing kidney yin, and life essence-filling, marrow-benefitting, is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five ZANG-organs is Kidney-Yin ", " mending greatly true water ".Normal be equal to use with Rhizoma Dioscoreae, Fructus Corni, treat the hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst etc., can invigorating the liver and kidney, and beneficial marrow, as LIUWEI DIHUANG WAN.

Specific embodiment 1:

Preparation: get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, dry 9h (it is fixed that the time is looked sample moisture, can 8～12h), take out and be placed in drying baker coolingly, pulverized 60 mesh sieves with pulverizer, powder is placed in brown wide mouthed bottle and stores.

Lixiviate: preparation 60% alcoholic solution (get 640mL95% ethanol, 360mL pure water is made into 60% alcoholic solution).Get 100g ginkgo leaf powder in 700mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, by filtered through gauze, in residue, add 60% ethanol 700mL, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do parallel laboratory test simultaneously.

Sucking filtration: first use gauze coarse filtration, remove bulky grain precipitation, to improve sucking filtration speed.Sucking filtration instrument is installed, in buchner funnel, is added a small amount of lixiviating solution to carry out sucking filtration, owing to containing gelatinous precipitate in Folium Ginkgo, filter paper easily results in blockage, and causes sucking filtration speed to decline, therefore should often change filter paper.After sucking filtration finishes, get filtrate and abandon filtering residue.

Distill, concentrate: distillation, concentrating appts are installed, in sucking filtration liquid, containing a large amount of alcoholic solution, with distilling apparatus, are carried out ethanol and concentrate.A certain amount of ethanol also has bactericidal action, when measuring extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, and ethanol is volatilized totally completely.In order not destroy effective ingredient in extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is 75 ℃ of left and right, therefore distillation speed is slow, the time is long.Can take simple method, direct heating in water bath, the ethanol that volatilizees, this method shortcoming: can not reclaim ethanol in air.The extract finally obtaining is part precipitation extractum, and color is dark-brown dope.

Dry: owing to still containing part ethanol and moisture in concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilize increase vacuum to reduce boiling point, remove last ethanol and residual part moisture.If conditions permit can also adopt freezing and drying lyophilization dry.In extract now, except containing flavonoid and lactone, also contain a certain amount of impurity.

All the other raw materials are granulated: by all the other raw material Fructus Rubies, and Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Fructus Corni, Radix Salviae Miltiorrhizae, Poria, heterophyllum, Radix Codonopsis, Herba Eupatorii, Herb Gynostemmae Pentaphylli, the Radix Astragali, Rhizoma Alismatis, Flos Carthami, Radix Scutellariae, the Radix Paeoniae Alba, Fructus Gardeniae, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Radix Et Rhizoma Fagopyri Tatarici, the agent of propolis granulation.

Packing: by the above-mentioned granule making, the Folium Ginkgo extract good with aforementioned dry in the sun mixes, and then can pack product, can be distributed into the essay bag of 10-15 gram, also can integral body be mixed into bag sale.

Specific embodiment 2:

Pluck the fresh and tender Folium Ginkgo of 2500g, clean, dry, in 70 ℃ of baking ovens, dry 9h, taking-up is placed in drying baker cooling, with pulverizer, pulverizes 60 mesh sieves, powder is placed in brown wide mouthed bottle storage preparation 60% alcoholic solution (get 640mL95% ethanol, 360mL pure water is made into 60% alcoholic solution).Get 1000g ginkgo leaf powder in 7000mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, by filtered through gauze, in residue, add 60% ethanol 7000mL, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do parallel laboratory test simultaneously.First use gauze coarse filtration, remove bulky grain precipitation, to improve sucking filtration speed.Sucking filtration instrument is installed, in buchner funnel, is added a small amount of lixiviating solution to carry out sucking filtration, owing to containing gelatinous precipitate in Folium Ginkgo, filter paper easily results in blockage, and causes sucking filtration speed to decline, therefore should often change filter paper.After sucking filtration finishes, get filtrate and abandon filtering residue.Distillation, concentrating appts are installed, in sucking filtration liquid, containing a large amount of alcoholic solution, with distilling apparatus, are carried out ethanol and concentrate.A certain amount of ethanol also has bactericidal action, when measuring extract bacteriostasis, should get rid of the interference of alcohol solvent as far as possible, and ethanol is volatilized totally completely.In order not destroy effective ingredient in extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is 75 ℃ of left and right, therefore distillation speed is slow, the time is long.Can take simple method, direct heating in water bath, the ethanol that volatilizees, this method shortcoming: can not reclaim ethanol in air.The extract finally obtaining is part precipitation extractum, and color is dark-brown dope.Owing to still containing part ethanol and moisture in concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilizes increase vacuum to reduce boiling point, removes last ethanol and residual part moisture.If conditions permit can also adopt freezing and drying lyophilization dry.By all the other raw material Fructus Rubi 500g, Radix Rehmanniae Preparata 500g, Radix Angelicae Sinensis 500g, Fructus Corni 500g, Radix Salviae Miltiorrhizae 500g, Poria 500g, heterophyllum 500g, Radix Codonopsis 500g, Herba Eupatorii 500g, Herb Gynostemmae Pentaphylli 500g, Radix Astragali 500g, Rhizoma Alismatis 500g, Flos Carthami 500g, Radix Scutellariae 500g, Radix Paeoniae Alba 500g, Fructus Gardeniae 500g, Rhizoma Atractylodis Macrocephalae 500g, Fructus Ligustri Lucidi 500g, Radix Et Rhizoma Fagopyri Tatarici 500g, propolis 500g puts it in 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, merges standing by 2 extracting solution; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged; concentrating under reduced pressure relative density is the filtrate of 1.36 (80 ℃); reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, extractum reduces pressure to obtain; putting into dehydrator dries; add dextrin, put into granulator and make 1-2 centimetre of granule, the Folium Ginkgo product extract finished product then obtaining with above-mentioned steps fully mixes; be distributed into the essay bag of 10-15 gram, also can integral body be mixed into bag sale.Can be distributed into the essay bag of 10-15 gram, also can integral body be mixed into bag sale.

Specific embodiment 3:

Pluck 1200g Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, dry 9h, taking-up is placed in drying baker cooling, with pulverizer, pulverized 60 mesh sieves, powder is placed in brown wide mouthed bottle storage preparation 60% alcoholic solution (get 640mL95% ethanol, 360mL pure water is made into 60% alcoholic solution).Get 500g ginkgo leaf powder in 3500mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, by filtered through gauze, in residue, add 60% ethanol 35000mL, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, and filtered through gauze merges lixiviating solution.Do parallel laboratory test simultaneously.First use gauze coarse filtration, remove bulky grain precipitation, to improve sucking filtration speed.Sucking filtration instrument is installed, in buchner funnel, is added a small amount of lixiviating solution to carry out sucking filtration, owing to containing gelatinous precipitate in Folium Ginkgo, filter paper easily results in blockage, and causes sucking filtration speed to decline, therefore should often change filter paper.After sucking filtration finishes, get filtrate and abandon filtering residue.Distillation, concentrating appts are installed, in sucking filtration liquid, containing a large amount of alcoholic solution, with distilling apparatus, are carried out ethanol and concentrate.In order not destroy effective ingredient in extract, bath temperature is controlled at 60 ℃～70 ℃, and the boiling point of 95% ethanol is 75 ℃ of left and right, therefore distillation speed is slow, the time is long.The extract finally obtaining is part precipitation extractum, and color is dark-brown dope.Owing to still containing part ethanol and moisture in concentrated lixiviating solution, adopt boulton process, temperature is controlled between 60 ℃～70 ℃, utilizes increase vacuum to reduce boiling point, removes last ethanol and residual part moisture.By all the other raw material Fructus Rubi 230g, Radix Rehmanniae Preparata 240g, Radix Angelicae Sinensis 230g, Fructus Corni 250g, Radix Salviae Miltiorrhizae 240g, Poria 250g, heterophyllum 240g, Radix Codonopsis 250g, Herba Eupatorii 240g, Herb Gynostemmae Pentaphylli 250g, Radix Astragali 240g, Rhizoma Alismatis 230g, Flos Carthami 250g, Radix Scutellariae 230g, Radix Paeoniae Alba 250g, Fructus Gardeniae 240g, Rhizoma Atractylodis Macrocephalae 220g, Fructus Ligustri Lucidi 230g, Radix Et Rhizoma Fagopyri Tatarici 220g, propolis 250g puts it in 10 times of water gagings and soaks.Drop into multi-function extractor and extract twice, add for the first time 8-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge twice decocting liquid, filter to get filtrate; Heating is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, is ground into fine powder.Then the Folium Ginkgo extract obtaining with above-mentioned steps fully mixes, and is distributed into the essay bag of 10-15 gram, also can integral body be mixed into bag sale.Can be distributed into the essay bag of 10-15 gram, also can integral body be mixed into bag sale.

Decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is fried, and not exclusively mouthfeel is poor, is not suitable for the Modern human populations medication custom.Because this aspect is mainly used in preventing and treating hyperlipemia, hyperglycemia, this disease belongs to multifactor relevant chronic disease, and the course of disease is longer, needs long-term prescription just can reach good effect, therefore should select to take, carry, health product easy to use.The features such as health product have the bad smell of covering, attractive in appearance, to be easy to swallow, and technique is simple, and onset is rapid, is applicable to long-term taking, can not damage health.

Pharmacology's toxicity test

Health product acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: health product of the present invention, containing 0.0365g crude drug/g.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, 10 every group, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.Adding distil water of the present invention is dissolved, be made into maximum concentration, by the maximum tolerated dose of animal, to inject, fill with hello device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, feedwater (interval half an hour) at twice in a day, each 0.5ml (every ml is containing crude drug 0.036g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.After administration, Continuous Observation is 7 days.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, there are no death.Select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Long term toxicity test data of the present invention

Chinese medicine of the present invention is through the gastric infusion long-term toxicity test for animals result of 6 months: SD rat is divided into three groups, 30 every group, male and female half and half (being divided into high, medium and low three dosage groups, 10 every group), wherein first group through gavage to normal saline; Second group is given dosage of the present invention through gavage is 0.25g, 2.5g and 12.5g/kg.d; The 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of lovastatin.During administration, the indexs such as clinical manifestation, hematology, blood biochemistry, organ coefficient and histopathology of observing respectively after each treated animal administration are carried out the evaluation of drug toxicity.Result of study: main toxic reaction shows lovastatin 50mg/kg.d and 5.0mg group, shows after administration that reaction and the symptoms such as sialorrhea, hair are fluffy, busy, diarrhoea, step have appearred in SD rat, total food ration and losing weight; Blood test shows that total white blood cells increases to some extent, erythrocyte sum, content of hemoglobin and platelet count obviously decline (the equal <0.05 of P); Blood biochemistry checking shows ALT, AST, ALP and 1～8 times (equal <0.05 of P) of CK rising, and creatinine and blood urea nitrogen raise (the equal <0.05 of P) to some extent, but do not cause animal dead; Histopathological analysis result shows that the Liver and kidney pathological change similar to people appearred in lovastatin 50mg/kg.d group.And all there is not similar reaction in tri-dosage groups of normal saline group and 0.25g of the present invention, 2.5g and 12.5g/kg.d and lovastatin 0.5mg/kg.d dosage group during whole administration, at convalescent period viewing duration, the symptom that occurs each treated animal of the reaction recovery normal condition that fades away.Visible the present invention not only can reduce the toxic and side effects of lovastatin, and can make the clinical non-toxic of lovastatin be increased to 5～25 times (the equal <0.01 of P).

The specific embodiment:

At present, blood fat-reducing blood pressure-decreasing product is all very fiery both at home and abroad, and traditional Chinese medicine capable of reducing weight blood fat-reducing blood pressure-decreasing health product is also a dark horse, sweep the country. but the research of health product blood fat-reducing blood pressure-decreasing effect, mainly with clinical observation on the therapeutic effect, be main greatly, the animal experiment study that less employing is tight, so that science is not strong, cogency is not enough.The present invention carrys out verification the verifying results with zoopery.

1 materials and methods

1.1 material

1.1.1 laboratory animal: 80 of ICR mices, public 40, female 40, body weight 18-22g, Shandong Medical University's laboratory animal

Center provides.

1.1.2 tested material: blood fat-reducing blood pressure-decreasing Semen Ginkgo product of the present invention, give health product granule of the present invention for tested group 1, give pasty state medicated powder of the present invention (in the present invention medicinal boiling water soak make pasty state standby) for tested group 2, give ginkgo Leaves health care product powder of the present invention for tested group 3.

1.2 experimental technique

1.2.1 Weight-reducing and lipid-lowering experimental technique

Get 40 mices, be divided at random 4 groups, 10 every group, tested group 1,2,3 gives respectively different tested materials, gives tested material every day once; Matched group is not done special handling, and each group is all fed with high lipid food, quantity-unlimiting, and feed continuously 15d. and weigh subsequently, separation of serum, and by GPO-PAP method and CHOD-PAP method, survey serum triglycerides and T-CHOL respectively; Dissect mice, isolate mouse testis place fatty tissue and weigh, the body weight between comparable group, fat weight, T-CHOL and triglyceride, carry out t check.

1.2.2 microcirculation experimental technique is got 40 mices, is divided at random 4 groups, 10 every group (male and female half and half), the every Mus auris dextra of matched group be coated with normal saline a little; The every Mus auris dextra of positive group is trained first HUOXUE ZHITONG GAO, give respectively different tested materials for tested group 1,2,3,15min pneumoretroperitoneum is injected 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein injection 0.1% epinephrine 0.1mL/10g, observes mouse right ear fine motion vein bore (Lm) and 0.2mm2 blood capillary net number .t check processing experimental data immediately subsequently.

2 results and discussion

2.1 interpretation of result

2.1.1 the impact of Mouse Weight, fat weight is compared with matched group, tested group 1 on the impact of Mouse Weight, fat weight little (P>0.05); Tested group of 2 pairs of Mouse Weights, fat weights have remarkable reducing effect (P<0.01); Tested group of 3 pairs of Mouse Weights, fat weight also have obvious reducing effect (P<0.05, P<0.01).

Table 1 Folium Ginkgo, Chinese medicinal granule and the present invention impact on Mouse Weight, fat weight

2.1.2 the impact of mice serum triglyceride, T-CHOL is compared with matched group, tested each group is to the reducing effect of mice serum T-CHOL not obvious (P>0.05), but serum triglycerides is all had to remarkable reducing effect (P<0.01), illustrates that tested medicinal liquid, granule, medicated powder and the two are combined with serum triglycerides is had to reducing effect (table 2).

The impact of table 2 the present invention on mice serum triglyceride, T-CHOL

2.2 discuss

2.2.1 regulate the main testing index a. of blood fat T-CHOL to measure; B. triglyceride determination.

2.2.2 improving microcirculation Weight-reducing health articles for use multipotency plays a role by improving microcirculation. and microcirculation is mainly viviperception, conventional look-out station is bulbar Conjunctiva Microcirculation, auricular microcirculation etc., and observation index is microvascular diameter, blood capillary site counting, blood capillary blood flow velocity, fluidised form, color, blood capillary variation around etc.By increasing the saturating property of blood vessel and elasticity, reduce blood pressure, have good antihypertensive effect.

Experimental result shows, the present invention all has obvious reducing effect to Mouse Weight, fat and serum triglycerides, and reduces blood pressure by increasing the saturating property of blood vessel and elasticity, has good antihypertensive effect; And can improve microcirculation, blood pressure lowering blood fat reducing hypoglycemic activity has been described.

But anemia of pregnant woman of the present invention and child, old man is careful.The main component flavone compound of Folium Ginkgo is a kind of powerful platelet activating factor inhibitor, and long-term taking may suppress hematoblastic cohesion function, and the danger of corresponding increase cerebral hemorrhage.Therefore, old people will stop before going too far when taking Folium Ginkgo, and notes regularly detecting blood coagulation situation, not blindness long-term taking.The patient who becomes fragile for existing senile sclerosis of blood vessels, blood vessel, more can not long-term taking, in order to avoid cause cerebral hemorrhage.In Folium Ginkgo, have a kind of composition ginkgoic acid, if the dosage of use is excessive, or Time of Administration is long, can damage heart.

Claims

1. Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, it is characterized in that, in described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product, the parts by weight of various raw materials are: 50～100 parts of Folium Ginkgos, 10～20 parts of Fructus Rubies, 10～20 parts, Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts, Poria, 10～20 parts of heterophyllum, 10～20 parts of Radix Codonopsis, 10～20 parts of Herba Eupatoriis, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Alismatis, 10～20 parts, Flos Carthami, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Gardeniaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of propolis,

The preparation method of described Folium Ginkgo blood fat-reducing blood pressure-decreasing health product is:

A. Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. ginkgo biloba succi sucking filtration;

D. sucking filtration liquid concentrates granulation thing, powder or unguentum;

E. by the agent of surplus stock granulation or powder;

F. the Folium Ginkgo extract granule making in step e or powder being made with steps d fully mixes, the molding of pack packing;

In described step b, get 640mL95% ethanol, 360mL pure water is made into 60% alcoholic solution; Then get 100g ginkgo leaf powder in 700mL60% ethanol, in water-bath, be heated to 60 ℃～70 ℃, lixiviate 2h, every 10min stirs once, by filtered through gauze, in residue, add 60% ethanol 700mL, 60 ℃～70 ℃ are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merge extractive liquid;

In described step e, surplus stock component is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, merges standing by 2 extracting solution; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged, and when being evaporated to relative density and being 80 ℃, 1.36 filtrate, reclaims ethanol; gained filtrate is adjusted to proportion to 1.06, and the extractum that reduces pressure to obtain, puts into dehydrator and dries; then add dextrin and be in harmonious proportion, put into granulator and make 1-2 centimetre of granule.

2. Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 1, it is characterized in that, in described health product, the parts by weight of various raw materials are: 50～85 parts of Folium Ginkgos, 10～15 parts of Fructus Rubies, 10～15 parts, Radix Rehmanniae Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～15 parts, Poria, 10～15 parts of heterophyllum, 10～15 parts of Radix Codonopsis, 10～15 parts of Herba Eupatoriis, 10～15 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Alismatis, 10～20 parts, Flos Carthami, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Gardeniaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of propolis.

3. Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 1, it is characterized in that, in described health product, the parts by weight of various raw materials are: 50～100 parts of Folium Ginkgos, 10～20 parts of Fructus Rubies, 10～20 parts, Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts, Poria, 10～20 parts of heterophyllum, 10～20 parts of Radix Codonopsis, 10～20 parts of Herba Eupatoriis, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Alismatis, 10～15 parts, Flos Carthami, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Gardeniaes, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～15 parts of propolis.

4. a preparation method for Folium Ginkgo blood fat-reducing blood pressure-decreasing health product as described in claim 1～3 any one, is characterized in that preparation method is:

A. Folium Ginkgo preparation is pulverized;

B. Folium Ginkgo extracts;

C. ginkgo biloba succi sucking filtration;

E. by the agent of surplus stock granulation or powder;

5. the preparation method of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4, it is characterized in that: in described step a, get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, dry 8-12h, taking-up is placed in drying baker cooling, with pulverizer, pulverizes 60 mesh sieves, and powder is placed in brown wide mouthed bottle and stores.

6. the preparation method of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4, is characterized in that: in described step c, ginkgo biloba succi is first used to gauze coarse filtration, remove bulky grain precipitation, to improve sucking filtration speed; Sucking filtration instrument is installed, in buchner funnel, is added a small amount of extracting solution to carry out sucking filtration, after sucking filtration finishes, get filtrate and abandon filtering residue.

7. the preparation method of Folium Ginkgo blood fat-reducing blood pressure-decreasing health product according to claim 4, is characterized in that: in described steps d, distillation, concentrating appts are installed, in sucking filtration liquid, containing a large amount of alcoholic solution, are carried out sucking filtration liquid concentrate granulation thing or unguentum with described instrument.