CN104474472A - Broadleaf holly leaf buccal tablet capable of reducing high blood pressure, high blood lipid and high blood glucose and production method of buccal tablet - Google Patents
Broadleaf holly leaf buccal tablet capable of reducing high blood pressure, high blood lipid and high blood glucose and production method of buccal tablet Download PDFInfo
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Abstract
The invention discloses a broadleaf holly leaf buccal tablet capable of reducing high blood pressure, high blood lipid and high blood glucose and a production method of the buccal tablet. The broadleaf holly leaf buccal tablet is characterized being prepared from the following raw materials in parts by weight: 90-100 parts of broadleaf holly leaves, 20-30 parts of momordica grosvenori, 8-12 parts of radix polygonati officinalis, 8-12 parts of rhinacanthus nasutus, 4-8 parts of persimmon leaves, 3-5 parts of radix curcumae longae, 3-5 parts of kelp, 1-2 parts of catharanthus roseus, 1-2 parts of nicotinic acid, 1-2 parts of menthol, 50-70 parts of filler and 10-15 parts of a lubricant. The broadleaf holly leaf buccal tablet capable of reducing high blood pressure, high blood lipid and high blood glucose has the characteristics of reducing high blood pressure, high blood lipid and high blood glucose, clearing away heat and toxic materials, tonifying spleen, calming nerves, losing weight, inhibiting and preventing cancer and the like.
Description
Technical field
The invention belongs to Chinese herbal medicine preparation technology field, be specifically related to a kind of to there is blood pressure lowering, blood fat reducing, the buccal lozenge of lectuce tea of hypoglycemic activity and production method thereof.
Background technology
Along with the raising of economic level in decades and the improvement of material conditions, the diet structure of people also there occurs subtle change.The diet of modern is transformed to nutrition heat surplus type by the simply having adequate food and clothing of past, and the thing followed is people is this great cost paid in healthy.Past many diseases just can only seen with it old people, as hypertension, hyperglycemia, hyperlipidemia etc. shift to young and middle-aged colony rapidly.In order to control and correct these deviations occurred in body, many people are had all to have to depend on various medicine to maintain the normal value of health indicator.In order to meet the need, current medical manufacturer has developed the chemicals of perhaps many blood pressure lowering, blood sugar lowering and blood fat reducing, although these medicines have much certain indexs to human body to recover really to serve obvious effect, but the many side effect of the thing followed have brought many new worries.Especially have many people, there is hypertension, hyperlipidemia and hyperglycemic symptoms with it at them simultaneously, for the treatment difficulty of these people and worry in the treatment just more.Many people are special in recent years wishes to remove slight illness by means of Chinese medicine.Although current existing Chinese medicine can treat respectively hypertension, hyperglycemia, hyperlipidemia medicine a lot, the medicine simultaneously can treating these three kinds of diseases is very not many.
Modern medicine study shows, containing 200 Multiple components such as Herba Lactucae formosanae Saponin, aminoacid, vitamin C, Polyphenols, flavonoid, caffeine, protein in Folium Ilicis, there is clearing away heat and removing summer, eyesight-improving intelligence-developing, promoting the production of body fluid to quench thirst, diuresis heart tonifying, the cough-relieving that wets one's whistle, blood fat reducing, blood pressure lowering, blood sugar lowering, fat-reducing, press down cancer anti-cancer, defying age, the multiple efficacies such as arteries and veins of invigorating blood circulation.It is one of study hotspot of tea health-care food, the edible way of Folium Camelliae sinensis is main mainly with bubble drink for a long time, and form is comparatively single, and utilization rate is not high enough, to steep with traditional bag or compared with the bubble that falls apart, Folium Camelliae sinensis buccal tablet is easy to carry, uses simple, can utilize its effective ingredient to greatest extent, meet modern's nourishing healthy, simple and efficient consumption demand, but due to problems such as tea flavour are too light, mouthfeel is not good, cause the degree of recognition in market not high, cannot meet the need of market.Therefore, develop a kind of have blood sugar lowering, blood pressure lowering, blood fat reducing buccal lozenge of lectuce tea be very important.
Summary of the invention
The object of the invention is not enough for above-mentioned prior art and provide one to have no side effect, there is blood sugar lowering, blood fat reducing, blood pressure lowering, also there is heat-clearing and toxic substances removing, spleen-benefiting mind-tranquilizing, fat-reducing, the buccal lozenge of lectuce tea pressing down cancer protective effect on cancer risk and production method thereof.
The present invention realizes by the following technical solutions:
The present invention has the buccal lozenge of lectuce tea falling three-hypers effect, is made up of the raw material of following parts by weight:
Folium Ilicis 90-100 part, Fructus Momordicae 20-30 part, Rhizoma Polygonati Odorati 8-12 part, white crane grass 8-12 part, Folium Kaki 4-8 part, Rhizoma Curcumae Longae 3-5 part, Thallus Laminariae (Thallus Eckloniae) 3-5 part, Herba Catharanthi Rosei 1-2 part, nicotinic acid 1-2 part, Mentholum 1-2 part, filler 50-70 part, lubricant 10-15 part.
Above-described have the buccal lozenge of lectuce tea falling three-hypers effect, is made up of the raw material of following parts by weight: Folium Ilicis 95 parts, Fructus Momordicae 25 parts, Rhizoma Polygonati Odorati 10 parts, white crane grass 10 parts, Folium Kaki 6 parts, 4 parts, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae) 4 parts, Herba Catharanthi Rosei 1 part, 1 part, nicotinic acid, Mentholum 1 part, filler 60 parts, lubricant 12 parts.
The present invention is made up of Chinese medicinal materials such as Folium Ilicis 95 parts, Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Roseis, again BN and Mentholum composite, there is blood sugar lowering, blood fat reducing, blood pressure lowering, also have heat-clearing and toxic substances removing, spleen-benefiting mind-tranquilizing, fat-reducing, press down cancer anti-cancer effect.
Above-described each medicine active ingredient with the buccal lozenge of lectuce tea Chinese medicine formula falling three-hypers effect is analyzed:
Folium Ilicis, [another name] Cortex Ilicis Rotundae; [Latin] Ilex latifolia Thunb, Cucurbitaceae is the leaf of holly plant Cortex Ilicis Rotundae (formal name used at school: Folium llicis Latifoliae), in being born in hillside, bamboo grove, bushes.Be distributed in THE LOWER YANGTZE VALLEY each province and Fujian.Folium Ilicis is commonly called as tea fourth, Fu Dingcha, highland Lu's tea, is a kind of traditional pure natural health-care beverage good merchantable brand of China, have the laudatory title such as " health tea ", " cosmetic tea ", " diet tea ", " blood-pressure decreasing tea ", " lengthen one's life tea ".[nature and flavor] are sweet, bitter, cold; [function cures mainly] has clearing away heat and removing summer, eyesight-improving intelligence-developing, promoting the production of body fluid to quench thirst, diuresis heart tonifying, the cough-relieving that wets one's whistle, blood fat reducing, blood pressure lowering, blood sugar lowering, fat-reducing, presses down cancer anti-cancer, defying age, the multiple efficacies such as arteries and veins of invigorating blood circulation.1. Compendium of Material Medica: Folium Ilicis has loose wind heat, refresh oneself, promoting the production of body fluid to quench thirst, help digestion refresh oneself, the pharmacological function such as eliminating inflammation and expelling toxin, hypertension and hyperlipemia.2. " book on Chinese herbal medicine is new again ": eliminate indigestion and phlegm, relieving restlessness is quenched the thirst, profit two just, is deoiled greasy.3. " Traditional Chinese Medicine in Sichuan will ": energy clearing away heat to dispel wind, relieving restlessness is quenched one's thirst.Control headache, toothache, tinnitus, conjunctival congestion and dyspepsia and have expectorant.
Fructus Momordicae, [another name] LAHANGUO, Herba Cardiospermi Halicacabi, Semen Momordicae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), arhat table, naked Testudinis bar; [Latin] Siraitia grosuenorii, Cucurbitaceae, growth is in the hillside sylvan life of height above sea level 300 ~ 1400 meters of subtropical zones, moistening location, river bank or scrub forest, and mainly originate in Longjiang township, Yongfu county, Guangxi Zhuang Autonomous Region Guilin City, dragon victory and hundred Shou Deng towns, [nature and flavor] sweet in the mouth is cool in nature; [function cures mainly] moistening and cleaning throat profit lung, relieving cough and resolving phlegm, laxation toxin expelling.1. " south of the Five Ridges gather medicinal herbs record ": reason phlegm-fire cough, and lean pork decoct soup and take it.2. " Guangxi Chinese medicinal herbal ": cough-relieving heat clearing away, removing heat from blood intestine moistening.Control cough, the dry gastric heat constipation of blood etc.Fruits nutrition is worth very high, containing abundant vitamin C (containing 400 milligrams ~ 500 milligrams in every 100 grams of fresh fruits) and glucoside, fructose, glucose, protein, lipid etc.
Rhizoma Polygonati Odorati, [another name] is luxuriant, Caulis Clematidis apiifoliae, save land, beautiful art, ring are yellow, seven, bamboo, Latin literary fame: the rhizome of Polygonatum odoratum (Mill.) Druce. Liliaceae herbaceos perennial Rhizoma Polygonati Odorati.Be distributed in northeast, North China, East China and Hubei, Hunan, Guangdong, Zhejiang, Inner Mongol, the ground such as Anhui.[nature and flavor] sweet, flat, [function cures mainly] calentura the moon wound, cough excessive thirst, deficient fever, frequent micturition, rapid digestion of food are easily hungry, also have blood fat reducing, blood pressure lowering, nourish, the effect of calm and heart tonifying.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": fill blood, invigorating middle warmer spleen invigorating.2. " Guangxi Chinese medicinal herbal ": nourishing YIN and clearing away lung-heat is moisturized.Control the deficiency of YIN, hyperhidrosis, cough caused by dryness, consumptive lung disease.
White crane grass, [another name] Herba Agrimoniae, Ramulus et Folium Rhinacanthi nasuti, Ganoderma lucidum seu Japonicum; [Latin] Agrimonia pilosa Ldb. be rosaceous plant Agrimony go up herb dryly, originate in Yunnan, China's Mainland, Guangdong, the Guangxi Mountains one in south China are with, the ground such as south east asia and India.Flavor efficacy: bitter, puckery, flat.[function cures mainly] lung-heat, heat syndrome cough, breath with cough, the disease such as pulmonary tuberculosis, esophagus tuberculosis, cacorhinia, bronchitis, laryngitis, hepatopathy, nephropathy, diabetes.
Folium Kaki, [another name] Folium Kaki; [Latin] Diospyros kaki L.f. Extract, Folium Kaki is the leaf of Ebenaceae magaphanerophytes Fructus Kaki; The fruit that China north and south all extensively distributes.[nature and flavor] bitter in the mouth, cold in nature, nontoxic; [function cures mainly] has slaking thirst and help produce saliva, the lung qi that disappears is swollen, reduce blood pressure, vessel softening, purify the blood and the effect of antiinflammatory.1. " book on Chinese herbal medicine is new again ": Folium Kaki is controlled cough and spitted blood, and slakes thirst and help produce saliva.2. " classify herbal ": Folium Kaki controls cough and asthma, the lung qi that disappears is swollen.
Rhizoma Curcumae Longae, [another name] Radix Curcumae, tripod perfume, milli life, Dioscorea zingiberensis; [Latin] Curcuma longa L. herbaceos perennial; Be distributed in the ground such as Fujian, Guangdong, Guangxi, Yunnan, Tibet.[nature and flavor] acrid in the mouth is bitter, and Great Cold, nontoxic, [function cures mainly] removing blood stasis, circulation of qi promoting, stimulates the menstrual flow, pain relieving, blood fat reducing.1. Tang Materia Medica: main trusted subordinate ties long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, removing blood stasis, except wind heat, subduing inflammation.2. " book on Chinese herbal medicine just ": except the depressed flatulence of trusted subordinate, cold air food stagnation pain.3. " modern Practical Chinese medicinal ": be fragrant stomachic, the disinfective action of favourable biliary tract and liver.
Thallus Laminariae (Thallus Eckloniae), [another name] synthetic fibre cloth, extra large Thallus Laminariae (Thallus Eckloniae); [Latin] Laminaria japonica Aiesch is the dry thallus of Laminariaceae plant Thallus Laminariae (Thallus Eckloniae) (Laminaria japonica Aresch) or Alariaceae plant Thallus Laminariae (Thallus Eckloniae) (goose palm dish) (Ecklonia kurome Okam).Respectively at the east area of the Liao River, coextensive with eastern and southern Liaoning Province, Shandong, Zhejiang, Fujian and other places.[nature and flavor] are salty, and cold, [function cures mainly] has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of inducing diuresis for treating stranguria syndrome; Cure mainly pyretic toxicity, carbuncle, skin infection, abscess of internal organ, conjunctival congestion and swelling pain, the disease such as damp and hot.1. the Pharmacopoeia of the People's Republic of China: 1. to thyroid effect: tool effect is because contained iodine, iodide cause.2. hypotensive effect: laminine (Laminine) has hypotensive effect, laminine list citrate, to anesthetized rabbit intravenous injection, can make the of short duration decline of blood pressure.3. hypoglycemic activity: in Thallus Laminariae (Thallus Eckloniae), contained laminaran 30ml/kg gavage has obvious hypoglycemic activity to normal mouse, when dosage reaches 100mg/kg, after 7 hours, blood glucose reduces by 49%.4. blood fat reducing and anticoagulation: laminarin is gavage repeatedly, can suppress the content of hyperlipidemia chicken serum T-CHOL, triglyceride to rise significantly, and can reduce formation and the development of chicken aortic tunica intima atheromatous plaque.
Herba Catharanthi Rosei, [another name] Calendula arvensis L., four time spring, everyday new, wild goose red, 30,000 flower; [Latin] Catharanthus roseus (L.) G. Don, Apocynaceae; It is comparatively general that (autonomous region) cultivation is economized in Guangdong, Guangxi, Yunnan etc.。[nature and flavor] are sweet, micro-hardship, and cold, [function cures mainly] has removing heat from blood blood pressure lowering, tranquillizing and allaying excitement.For hypertension, burning hot wound, malignant lymphoma, chorionic epithelioma, monocytic leukemia.。1. Guangzhou army " conventional Chinese herbal medicine handbook ": tranquillizing and allaying excitement, suppressing the hyperactive liver blood pressure lowering.Control hypertension.2. " register planted by Guangxi medicine ": treating leukemia, pulmonary carcinoma, chorionic epithelioma, lymph tumor.3. " conventional Chinese herbal medicine color atlas ": treatment Hokdkin disease, malignant tumor.
Nicotinic acid is also referred to as vitamin B3, or vitamin PP, molecular formula: C6H5NO2, heat-resisting, can distil, have the effect of Intensive Lipid-lowing.It is one of 13 kinds of vitamin of needed by human, is a kind of water soluble vitamins, belongs to vitamin B complex.Nicotinic acid is converted into nicotiamide in human body, and nicotiamide is the ingredient of cozymase and codehydrogenase Ⅱ, participates in HypercholesterolemicRats, the oxidizing process of Tissue respiration and the process of saccharide anaerobic decomposition.
Mentholum is a kind of chemical agent, is extracted by the leaf of Herba Menthae and stem, white crystal, molecular formula C
10h
20o is the main component in Herba Menthae and lavender quintessence oil.Being pharmaceutically used as excitants, acting on skin or mucosa, having refrigerant itching-relieving action; Take orally and can be used as carminative, for headache and nose; Pharynx; Laryngitis etc.Its ester is used for spice and medicine.
The production method that the present invention has the buccal lozenge of lectuce tea falling three-hypers effect made by above-mentioned each component medicine, comprises the following steps:
(1) pour extraction pot into after being pulverized by Folium Ilicis by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution A;
(2) medicinal residues after filtration in step 1 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution B;
(3) medicinal residues after filtration in step 2 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, extracting solution A and extracting solution B is mixed stirring, the ethanol adding extracting solution weight 5 times precipitates again, and filters after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by;
(4) Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Rosei is poured into extraction pot after pulverizing by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35 DEG C-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution C;
(5) medicinal residues after filtration in step 4 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution D;
(6) medicinal residues after filtration in step 5 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, then extracting solution C and extracting solution D to be mixed, first add nicotinic acid and Mentholum stirs, the ethanol adding extracting solution weight 5 times again precipitates, filter after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by.
(7) concentrated solution of the concentrated solution of 60-70% step 3 and 30-40% step 6 is poured in material-compound tank mix, stir after adding filler and wet and slippery dose, be condensed into thick paste and make soft material; Soft material is crossed 18 eye mesh screens and carry out pelletize, then dry under 50-60 DEG C of condition, gained granule carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described alcohol settling is that the ethanol of 80-90% adds in concentrated solution by mass fraction, slowly adds while stirring, and when being adjusted to that in concentrated solution, alcohol content is 40-70%, airtight 2-4 hour refilters.
Above-described filler is dextrin, microcrystalline Cellulose, modified starch, pregelatinized Starch, xylitol, one or more in carboxymethyl starch sodium.
Above-described wet and slippery dose is one or more in stearate, Pulvis Talci, hydride vegetable oil, Polyethylene Glycol.
There is the buccal lozenge of lectuce tea falling three-hypers effect, according to the condition of different situations and processing factory, Folium Ilicis liquid beverage, Herba Lactucae formosanae teabag, Folium Ilicis dissolved granule and other goods can also be made.
The invention has the beneficial effects as follows:
1, pharynx-clearing throat-benefiting buccal lozenge of lectuce tea of the present invention adopts and originates from Daxin County, Guangxi Folium Ilicis, herbaceous plant is refining forms for the Fructus Momordicae etc. of Guilin, Folium Ilicis, Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Rosei are all the raw materials of medicine-food two-purpose, have no side effect, without bad smell, mouthfeel is pure and fresh, natural, tasty and refreshing.
2, buccal lozenge of lectuce tea of the present invention to treatment hypertension, cerebral arteriosclerosis, blood fat reducing, blood sugar lowering, reduction cholesterol, obesity, prevent and treat that diabetes have fast, specially good effect; Also there is heat-clearing and toxic substances removing, spleen-benefiting mind-tranquilizing, fat-reducing, press down cancer protective effect on cancer risk; The thorough hardship relieving the three-hypers patient serious illness, and make healthy population obtain effective health care, without any side effects, safe and reliable.
3, buccal lozenge of lectuce tea of the present invention adds nicotinic acid, Mentholum and Fructus Momordicae, makes buccal lozenge of lectuce tea mouthfeel micro-sweet, salubrious, eliminates the bitterness of Folium Ilicis, and liking more by three-hypers crowd, also suitable any crowd takes.
4, the present invention is added into Fructus Momordicae, modern medicine and pharmacology research finds, Fructus Momordicae contains abundant glucoside, the sugariness of this glucoside is 300 times of sweetness of cane sugar, does not produce heat, is the famous and precious raw material of beverage, confectionery industry, it is the best substitute of sucrose, not raise blood sugar, and have hypoglycemic activity, can be used for adjuvant therapy of diabetes; So be the dietetic therapy good merchantable brand of diabetic.
5, material composition of the present invention and weight portion are through long-term test with repeatedly compare and use, and have drawn scientific compatibility, mutually for, inseparable, there is good therapeutic effect.
Detailed description of the invention
Embodiment 1:
(1) raw material and weight:
Folium Ilicis 90 parts, Fructus Momordicae 20 parts, Rhizoma Polygonati Odorati 8 parts, white crane grass 8 parts, Folium Kaki 4 parts, 3 parts, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae) 3 parts, Herba Catharanthi Rosei 1 part, 1 part, nicotinic acid, Mentholum 1 part, filler 50 parts, lubricant 10 parts.
(2) production method:
(1) pour extraction pot into after being pulverized by Folium Ilicis by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution A;
(2) medicinal residues after filtration in step 1 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution B;
(3) medicinal residues after filtration in step 2 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, extracting solution A and extracting solution B is mixed stirring, the ethanol adding extracting solution weight 5 times precipitates again, and filters after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by;
(4) Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Rosei is poured into extraction pot after pulverizing by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35 DEG C-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution C;
(5) medicinal residues after filtration in step 4 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution D;
(6) medicinal residues after filtration in step 5 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, then extracting solution C and extracting solution D to be mixed, first add nicotinic acid and Mentholum stirs, the ethanol adding extracting solution weight 5 times again precipitates, filter after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by.
(7) concentrated solution of the concentrated solution of 60-70% step 3 and 30-40% step 6 is poured in material-compound tank mix, stir after adding filler and wet and slippery dose, be condensed into thick paste and make soft material; Soft material is crossed 18 eye mesh screens and carry out pelletize, then dry under 50-60 DEG C of condition, gained granule carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described filler is dextrin; Above-described wet and slippery dose is stearate.
Embodiment 2:
(1) raw material and weight:
Folium Ilicis 95 parts, Fructus Momordicae 25 parts, Rhizoma Polygonati Odorati 10 parts, white crane grass 10 parts, Folium Kaki 6 parts, 4 parts, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae) 4 parts, Herba Catharanthi Rosei 1 part, 1 part, nicotinic acid, Mentholum 1 part, filler 60 parts, lubricant 12 parts.
(2) production method:
(1) pour extraction pot into after being pulverized by Folium Ilicis by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution A;
(2) medicinal residues after filtration in step 1 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution B;
(3) medicinal residues after filtration in step 2 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, extracting solution A and extracting solution B is mixed stirring, the ethanol adding extracting solution weight 5 times precipitates again, and filters after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by;
(4) Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Rosei is poured into extraction pot after pulverizing by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35 DEG C-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution C;
(5) medicinal residues after filtration in step 4 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution D;
(6) medicinal residues after filtration in step 5 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, then extracting solution C and extracting solution D to be mixed, first add nicotinic acid and Mentholum stirs, the ethanol adding extracting solution weight 5 times again precipitates, filter after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by.
(7) concentrated solution of the concentrated solution of 60-70% step 3 and 30-40% step 6 is poured in material-compound tank mix, stir after adding filler and wet and slippery dose, be condensed into thick paste and make soft material; Soft material is crossed 18 eye mesh screens and carry out pelletize, then dry under 50-60 DEG C of condition, gained granule carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described filler is xylitol; Above-described wet and slippery dose is Pulvis Talci.
Embodiment 3:
(1) raw material and weight:
Folium Ilicis 98 parts, Fructus Momordicae 28 parts, Rhizoma Polygonati Odorati 11 parts, white crane grass 11 parts, Folium Kaki 7 parts, 4 parts, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae) 4 parts, Herba Catharanthi Rosei 2 parts, 2 parts, nicotinic acid, Mentholum 2 parts, filler 65 parts, lubricant 14 parts.
(2) production method:
(1) pour extraction pot into after being pulverized by Folium Ilicis by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution A;
(2) medicinal residues after filtration in step 1 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution B;
(3) medicinal residues after filtration in step 2 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, extracting solution A and extracting solution B is mixed stirring, the ethanol adding extracting solution weight 5 times precipitates again, and filters after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by;
(4) Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Rosei is poured into extraction pot after pulverizing by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35 DEG C-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution C;
(5) medicinal residues after filtration in step 4 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution D;
(6) medicinal residues after filtration in step 5 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, then extracting solution C and extracting solution D to be mixed, first add nicotinic acid and Mentholum stirs, the ethanol adding extracting solution weight 5 times again precipitates, filter after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by.
(7) concentrated solution of the concentrated solution of 60-70% step 3 and 30-40% step 6 is poured in material-compound tank mix, stir after adding filler and wet and slippery dose, be condensed into thick paste and make soft material; Soft material is crossed 18 eye mesh screens and carry out pelletize, then dry under 50-60 DEG C of condition, gained granule carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described filler is carboxymethyl starch sodium; Above-described wet and slippery dose is hydride vegetable oil.
Embodiment 4:
(1) raw material and weight:
Folium Ilicis 100 parts, Fructus Momordicae 30 parts, Rhizoma Polygonati Odorati 12 parts, white crane grass 12 parts, Folium Kaki 8 parts, 5 parts, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae) 5 parts, Herba Catharanthi Rosei 2 parts, 2 parts, nicotinic acid, Mentholum 2 parts, filler 70 parts, lubricant 15 parts.
(2) production method:
(1) pour extraction pot into after being pulverized by Folium Ilicis by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution A;
(2) medicinal residues after filtration in step 1 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution B;
(3) medicinal residues after filtration in step 2 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, extracting solution A and extracting solution B is mixed stirring, the ethanol adding extracting solution weight 5 times precipitates again, and filters after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by;
(4) Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Rosei is poured into extraction pot after pulverizing by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35 DEG C-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution C;
(5) medicinal residues after filtration in step 4 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution D;
(6) medicinal residues after filtration in step 5 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, then extracting solution C and extracting solution D to be mixed, first add nicotinic acid and Mentholum stirs, the ethanol adding extracting solution weight 5 times again precipitates, filter after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by.
(7) concentrated solution of the concentrated solution of 60-70% step 3 and 30-40% step 6 is poured in material-compound tank mix, stir after adding filler and wet and slippery dose, be condensed into thick paste and make soft material; Soft material is crossed 18 eye mesh screens and carry out pelletize, then dry under 50-60 DEG C of condition, gained granule carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described filler is dextrin, microcrystalline Cellulose, modified starch and xylitol; Above-described wet and slippery dose is hydride vegetable oil and Polyethylene Glycol.
application Example
Of the present invention have the buccal lozenge of lectuce tea falling three-hypers effect and to study in 2012 and the product manufacturing experimently out is taken to part population, and volunteer 30, wherein has the symptoms such as diabetes, hypertension, hyperlipidemia.Take 4-8 sheet every day, after taking 3-5 days, three indexs all have obviously decline have 27 people, result patient takes rear effective percentage and reaches more than 90%, and except 3 symptom more severe cases need except hospital treatment, 27 all do not spend hospital, also do not take Western medicine.For hypertension, the hyperlipemic patients of suffering from severe diabetes mellitus, other hypoglycemic drug is coordinated while taking medicine of the present invention, blood pressure, blood fat obviously decline, the consumption of other hypoglycemic medicine also can reduce 10% to 30%, glycolated hemoglobin value also obviously declines, and prompting blood glucose tends to be steady.
Model case
1, Peng so-and-so, female, 45 years old, is diagnosed as hyperlipidemia in November, 2013 and holds concurrently coronary heart disease, takes the cardiovascular and cerebrovascular disease medicines such as Radix Salviae Miltiorrhizae Tabellae, brain blood are logical, SUXIAO JIUXIN WAN every day, does not feel any better; Through taking buccal lozenge of lectuce tea of the present invention, take 4-8 sheet every day, after 2 days, symptom greatly alleviates, and after taking a week, blood pressure is steady, and examination in hospital after month, blood fat index is normal.
2, the Qin so-and-so, man, 55 years old, certain top managers, suffer from diabetes, after the treatment of the large hospital such as Beijing, Shanghai, poor effect, frequent insulin injection and superpower antioxidant therapy, through taking buccal lozenge of lectuce tea of the present invention, take 4-8 sheet every day, after 5 days, blood pressure, blood glucose decline, after taking three courses for the treatment of continuously, glycemic index is normal, treats without the need to insulin injection.
3, Tan, man, 62 years old, because of insobriety of often smoking, suffers from hypertension, hyperlipidemia and coronary heart disease for many years, through taking buccal lozenge of lectuce tea of the present invention, take 4-8 sheet every day, after the course for the treatment of, blood pressure, blood fat are steady, after 30 days, blood pressure, blood fat recover normal, often take at ordinary times, until also do not recur so far.
4, Zhang, female, 52 years old, teacher, change diabetes for many years, every day got up in the night to urinate 7-8 time, and after taking one week of buccal lozenge of lectuce tea of the present invention, number of times of getting up in the night to urinate every day is reduced to 2-3 time.
5, Wei, 72 years old, suffers from the diseases such as hypertension, hyperlipidemia and insomnia for many years, adheres to taking buccal lozenge of lectuce tea of the present invention, every day 3 times, each containing with 2, sleep after the week normal, hypertension and hyperlipidemia index decline, and after continuing to take 1 month, blood pressure, blood fat recover normal.
Claims (6)
1. there is the buccal lozenge of lectuce tea falling three-hypers effect, it is characterized in that: be made up of the raw material of following parts by weight: Folium Ilicis 90-100 part, Fructus Momordicae 20-30 part, Rhizoma Polygonati Odorati 8-12 part, white crane grass 8-12 part, Folium Kaki 4-8 part, Rhizoma Curcumae Longae 3-5 part, Thallus Laminariae (Thallus Eckloniae) 3-5 part, Herba Catharanthi Rosei 1-2 part, nicotinic acid 1-2 part, Mentholum 1-2 part, filler 50-70 part, lubricant 10-15 part.
2. according to claim 1 have the buccal lozenge of lectuce tea falling three-hypers effect, it is characterized in that: be made up of the raw material of following parts by weight: Folium Ilicis 95 parts, Fructus Momordicae 25 parts, Rhizoma Polygonati Odorati 10 parts, white crane grass 10 parts, Folium Kaki 6 parts, 4 parts, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae) 4 parts, Herba Catharanthi Rosei 1 part, 1 part, nicotinic acid, Mentholum 1 part, filler 60 parts, lubricant 12 parts.
3. have a production method for the buccal lozenge of lectuce tea falling three-hypers effect, it is characterized in that: the extraction comprising the extraction of Folium Ilicis effective ingredient and Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Rosei effective ingredient, concrete steps are as follows:
(1) pour extraction pot into after being pulverized by Folium Ilicis by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution A;
(2) medicinal residues after filtration in step 1 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution B;
(3) medicinal residues after filtration in step 2 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, extracting solution A and extracting solution B is mixed stirring, the ethanol adding extracting solution weight 5 times precipitates again, and filters after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by;
(4) Fructus Momordicae, Rhizoma Polygonati Odorati, white crane grass, Folium Kaki, Rhizoma Curcumae Longae, Thallus Laminariae (Thallus Eckloniae), Herba Catharanthi Rosei is poured into extraction pot after pulverizing by weight, add 10 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusion 1.5-2 hour, when fluid temperature is down to 35 DEG C-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution C;
(5) medicinal residues after filtration in step 4 are added 5 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 1 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, obtain extracting solution D;
(6) medicinal residues after filtration in step 5 are added 3 times that the water yield is medicine gross weight, be heated to 100 DEG C of infusions 0.5 hour, when fluid temperature is down to 35-50 DEG C, filter through 120 eye mesh screens, then extracting solution C and extracting solution D to be mixed, first add nicotinic acid and Mentholum stirs, the ethanol adding extracting solution weight 5 times again precipitates, filter after alcohol settling 2-4 hour, vacuum concentration is the concentrated solution of 1.3 to proportion, preserves stand-by;
(7) concentrated solution of the concentrated solution of 60-70% step 3 and 30-40% step 6 is poured in material-compound tank mix, stir after adding filler and wet and slippery dose, be condensed into thick paste and make soft material; Soft material is crossed 18 eye mesh screens and carry out pelletize, then dry under 50-60 DEG C of condition, gained granule carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
4. the production method with the buccal lozenge of lectuce tea falling three-hypers effect according to claim 3, it is characterized in that: described alcohol settling is that the ethanol of 80-90% adds in concentrated solution by mass fraction, slowly add while stirring, when being adjusted to that in concentrated solution, alcohol content is 40-70%, airtight 2-4 hour refilters.
5. the production method with the buccal lozenge of lectuce tea falling three-hypers effect according to claim 3, is characterized in that: described filler is dextrin, microcrystalline Cellulose, modified starch, pregelatinized Starch, xylitol, one or more in carboxymethyl starch sodium.
6. the production method with the buccal lozenge of lectuce tea falling three-hypers effect according to claim 3, is characterized in that: described wet and slippery dose is one or more in stearate, Pulvis Talci, hydride vegetable oil, Polyethylene Glycol.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055901A (en) * | 2015-07-30 | 2015-11-18 | 广西健宝石斛有限责任公司 | Capsule containing dendrobium officinale and preparation method thereof |
| CN106722992A (en) * | 2016-12-20 | 2017-05-31 | 钦州市星火计划办公室 | A kind of persimmon lozenge and preparation method thereof |
| CN107669984A (en) * | 2017-11-01 | 2018-02-09 | 李西平 | A kind of composition and its solid beverage and preparation method for being used to treat high fat of blood |
| JP2021138647A (en) * | 2020-03-04 | 2021-09-16 | 株式会社栄進製薬 | Blood glucose level elevation inhibitor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001199996A (en) * | 2000-01-24 | 2001-07-24 | Pola Chem Ind Inc | ACYL-CoA CHOLESTERYL ACYLTRANSFERASE INHIBITOR AND COMPOSITION COMPRISING THE SAME FOR HYPERLIPIDEMIA |
| CN1370593A (en) * | 2002-02-08 | 2002-09-25 | 赵宝忠 | Ilicis Folium buccal tablet |
| CN104082480A (en) * | 2014-06-19 | 2014-10-08 | 谭卓勇 | Sugar-free platycodon root tea drink and preparation method thereof |
-
2014
- 2014-12-03 CN CN201410722040.7A patent/CN104474472B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001199996A (en) * | 2000-01-24 | 2001-07-24 | Pola Chem Ind Inc | ACYL-CoA CHOLESTERYL ACYLTRANSFERASE INHIBITOR AND COMPOSITION COMPRISING THE SAME FOR HYPERLIPIDEMIA |
| CN1370593A (en) * | 2002-02-08 | 2002-09-25 | 赵宝忠 | Ilicis Folium buccal tablet |
| CN104082480A (en) * | 2014-06-19 | 2014-10-08 | 谭卓勇 | Sugar-free platycodon root tea drink and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| IAPS: "降血脂秘方", 《HTTP://WWW.360DOC.COM/CONTENT/12/0711/07/7820845_223502113.SHTML》 * |
| 朱成全等: "《防治‘四高’药膳大全》", 28 February 2014, 中国医药科技出版社 * |
| 李秀才: "《糖尿病的中医治疗》", 30 November 2007, 科学技术文献出版社 * |
| 杨卫平等: "《新编中草药图谱及经典配方2》", 31 May 2014, 贵州科技出版社 * |
| 林寿宁等: "《慢性胃炎、消化性溃疡中医防治与调养》", 28 February 2010, 化学工业出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055901A (en) * | 2015-07-30 | 2015-11-18 | 广西健宝石斛有限责任公司 | Capsule containing dendrobium officinale and preparation method thereof |
| CN106722992A (en) * | 2016-12-20 | 2017-05-31 | 钦州市星火计划办公室 | A kind of persimmon lozenge and preparation method thereof |
| CN107669984A (en) * | 2017-11-01 | 2018-02-09 | 李西平 | A kind of composition and its solid beverage and preparation method for being used to treat high fat of blood |
| JP2021138647A (en) * | 2020-03-04 | 2021-09-16 | 株式会社栄進製薬 | Blood glucose level elevation inhibitor |
| JP7090267B2 (en) | 2020-03-04 | 2022-06-24 | 株式会社栄進製薬 | Blood sugar rise inhibitor |
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