CN107669984A - A kind of composition and its solid beverage and preparation method for being used to treat high fat of blood - Google Patents
A kind of composition and its solid beverage and preparation method for being used to treat high fat of blood Download PDFInfo
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- CN107669984A CN107669984A CN201711057859.6A CN201711057859A CN107669984A CN 107669984 A CN107669984 A CN 107669984A CN 201711057859 A CN201711057859 A CN 201711057859A CN 107669984 A CN107669984 A CN 107669984A
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- 210000004369 blood Anatomy 0.000 title claims abstract description 31
- 239000008280 blood Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 235000013361 beverage Nutrition 0.000 title claims abstract description 10
- 239000007787 solid Substances 0.000 title claims abstract description 9
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- 235000003392 Curcuma domestica Nutrition 0.000 claims abstract description 7
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- 235000013976 turmeric Nutrition 0.000 claims abstract description 7
- 244000119298 Emblica officinalis Species 0.000 claims abstract description 5
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 241000576429 Forsythia suspensa Species 0.000 description 1
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 description 1
- 240000002948 Ophiopogon intermedius Species 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
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- 229920002678 cellulose Polymers 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229960002297 fenofibrate Drugs 0.000 description 1
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 description 1
- 229960003627 gemfibrozil Drugs 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 1
- 229960004844 lovastatin Drugs 0.000 description 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
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- 238000001356 surgical procedure Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
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- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of composition and its solid beverage and preparation method for being used to treat high fat of blood.Said composition is mainly prepared by bulk drugs such as emblic, radix polygonati officinalis, turmeric, Ilex Latifolia Thunb and radix cynanchi bungeis according to different parts by weight；Said composition has good therapeutic effect to hyperlipemia.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of composition and its solid beverage and system for being used to treat high fat of blood
Preparation Method.
Background technology
Hyperlipidemia refers to that blood lipid level is too high, the disease that can directly cause some to seriously endanger health, such as artery
Atherosis, coronary heart disease, pancreatitis etc., it is a kind of common disease, blood fat is the general name of contained lipoids in blood, is led in blood fat
Cholesterol, triglyceride, phosphatide, aliphatic acid etc. are included, the incidence of disease is high among the elderly, and it can cause artery athero-
Hardening, or even coronary heart disease, cerebral thrombus, cerebral hemorrhage etc., entail dangers to life when serious；Therefore, the seriousness of hyperlipidemia is absolutely not
It can ignore, be that feed is fatty and cholesterol food is excessive while relevant with inherent cause etc. the main reason for Hyperlipemia
System.
The mode for the treatment of high fat of blood mainly has drug therapy and operative treatment, expenses of surgical treatment height and therapeutic effect at present
Differ, suitable for the invalid extremely difficult hypercholesterolemiapatients patients controlled of only a few other treatment method, treat the west of hyperlipemia
Medicine has fenofibrate, Gemfibrozil Capsules, Lovastatin etc., but Western medicine can not effect a radical cure hyperlipidemia, or even plays reaction to the state of an illness,
Also part Chinese medicine preparation is used to treat hyperlipemia, existing patent No. CN104606404A discloses a kind of preventing and treating high fat of blood
Chinese medicine composition and preparation method thereof, said composition are made up of hawthorn, Ilex Latifolia Thunb, polygala etc., and the Chinese medicine preparation can be used in controlling
Hyperlipemia is treated, but the preparation method of said composition is to crush all medicines, it is impossible to effectively reject impurity, fill active ingredient
That divides extracts, so as to influence drug effect；Patent No. CN104474472A provides the buccal lozenge of lectuce tea with three high drop effect
And its production method, the lozenge have used the taste Chinese medicine material of Ilex Latifolia Thunb, Momordica grosvenori, radix polygonati officinalis, turmeric, catharanthus roseus etc. 10, but its group
Side is complicated, and production cost is higher, therefore is badly in need of a kind of efficient long-acting, the simple Chinese medicine preparation of prescription, for treating high fat of blood
Disease crowd.
The content of the invention
In order to solve the problems such as drug effect in the prior art is low, prescription is complicated, it is used to treat high blood the invention provides one kind
The composition and its solid beverage and preparation method of fat, said composition good effect, prescription are simple, available for clearing heat and expelling damp, promote the production of body fluid
Moisturize, sample and tune, are more satisfactory fat-reducing foods.
Concrete technical scheme of the present invention is as follows:
The invention provides a kind of composition for treating high fat of blood, said composition is mainly prepared by the raw material of following parts by weight
Form:
The present invention show that the composition formed using above bulk drug can effectively treat high blood by largely testing
Fat.
Further to improve, composition also includes the seabed coconut that parts by weight are 5-30 and 10-20 hippocampus does.
It after the present invention adds above-mentioned 2 kinds of bulk drugs in the composition, can act synergistically with each component, further improve
The effect of composition treatment high fat of blood.
Further to improve, said composition is prepared by the bulk drug of following parts by weight:
Further to improve, said composition is prepared by the following method:
1) after each material is weighed in proportion, be soaked in water 1-3h respectively；
2) raw material after soaking is taken, is boiled 3 times with decocting, each amount of water is 8-12 times of raw material gross weight, decocts 2- every time
4h, merging filtrate after filtering, take 75% alcohol reflux of 2-3 times of weight of filter residue filter residue to extract 2h, decocting liquid is obtained, then by filtrate
Merge with decocting liquid, filter, concentration, dry to powder, produce the composition.
Further to improve, the preparation method of said composition specifically comprises the following steps:
A weighs emblic, radix polygonati officinalis and turmeric according to parts by weight, is decocted 3 times with the pressurization of 65% ethanol solution, added for the first time
Amount of alcohol is 5 times of bulk drug gross weight, decocts 1h, second plus amount of alcohol is bulk drug gross weight 4 times, decoct 1.5h, the 3rd
Secondary plus amount of alcohol is 4 times of bulk drug gross weight, decocts 0.5h, merges each secondary filtrate, is filtered, concentration, by macropore tree on concentrate
Fat is adsorbed, and with 72% ethanol elution, eluent is concentrated and dried to powder；
B weighs residual drug in composition according to parts by weight, is positioned in 60 DEG C of baking ovens and dries 30min, is ground into
1cm2, be soaked in water 0.5h, with the water ultrasonic extraction 3h of 10 times of amounts, filtering, and 6 times of water refluxing extractions 3 times measured of residue, every time
30min, merge each secondary filtrate, concentration, dry to powder；
The dried powder that c combining steps a and step b is obtained is well mixed, and produces the composition.
The composition prepared by above method can significantly improve the content of active ingredient in each medicine, make the group of preparation
Compound has more preferable therapeutic effect to high fat of blood.
In order to convenient to take and medicine is reached the effect of more preferable, granule is made in composition and auxiliary material by the present invention, its
In, the ratio of weight and number of composition and auxiliary material is 1:2-5.
Further to improve, auxiliary material includes sorbitan fatty acid ester, the 1-10 polyoxyethylene that parts by weight are 2-5
The microcrystalline cellulose of monoester acid esters, 2-5 polyvinylpyrrolidone and 4-8.
The present invention is by using sorbitan fatty acid ester, polyoxyethylene monoester acid esters, polyvinylpyrrolidone and crystallite
Cellulose can strengthen the melting of medicine, allow medicament to quickly dissolve in water as auxiliary material.
For the ease of taking, granule, sweetener and water are prepared into solid beverage by the present invention.
Further to improve, the ratio of weight and number of granule, sweetener and water is 2:0.1-0.5:1-1.5.
Wherein, sweetener can be any water-soluble sweetening agent such as Aspartame.
The present invention can improve the mouthfeel of composition, strengthen complying with for patient by the way that composition is being prepared into solid beverage
Property, and be convenient for carrying and transport, beneficial to preservation and storage.
Composition provided by the invention can be made to the product for the treatment of or auxiliary treatment high fat of blood, have to high fat of blood aobvious
The effect of work, after being prepared into solid beverage, water and sweetener etc. can be added and reconstituted, mouthfeel is sweet, bitter suitable, can be effective
The lipids contents of patient's body are reduced, improve the quality of life of medication patient.
Embodiment
Embodiment 1
A kind of composition, said composition are made up of the composition of following parts by weight:
Embodiment 2
A kind of composition, said composition are made up of the composition of following parts by weight:
Embodiment 3
A kind of composition, said composition are made up of the composition of following parts by weight:
Embodiment 4
A kind of composition, said composition are made up of the composition of following parts by weight:
The preparation method of said composition is:
A weighs emblic, radix polygonati officinalis and turmeric according to parts by weight, is decocted 3 times with the pressurization of 65% ethanol solution, added for the first time
Amount of alcohol is 5 times of bulk drug gross weight, decocts 1h, second plus amount of alcohol is bulk drug gross weight 4 times, decoct 1.5h, the 3rd
Secondary plus amount of alcohol is 4 times of bulk drug gross weight, decocts 0.5h, merges each secondary filtrate, is filtered, concentration, by macropore tree on concentrate
Fat is adsorbed, and with 72% ethanol elution, eluent is concentrated and dried to powder；
B weighs residual drug in composition according to parts by weight, is positioned in 60 DEG C of baking ovens and dries 30min, is ground into
1cm2, be soaked in water 0.5h, with the water ultrasonic extraction 3h of 10 times of amounts, filtering, and 6 times of water refluxing extractions 3 times measured of residue, every time
30min, merge each secondary filtrate, concentration, dry to powder；
The dried powder that c combining steps a and step b is obtained is well mixed, and produces the composition.
Embodiment 5
A kind of composition, said composition are made up of the composition of following parts by weight:
Embodiment 6
A kind of composition, said composition are made up of the composition of following parts by weight:
Embodiment 7
A kind of composition, said composition are made up of the composition of following parts by weight:
Embodiment 8
A kind of composition, said composition are made up of the composition of following parts by weight:
The preparation method of said composition is:
A weighs emblic, radix polygonati officinalis and turmeric according to parts by weight, is decocted 3 times with the pressurization of 65% ethanol solution, added for the first time
Amount of alcohol is 5 times of bulk drug gross weight, decocts 1h, second plus amount of alcohol is bulk drug gross weight 4 times, decoct 1.5h, the 3rd
Secondary plus amount of alcohol is 4 times of bulk drug gross weight, decocts 0.5h, merges each secondary filtrate, is filtered, concentration, by macropore tree on concentrate
Fat is adsorbed, and with 72% ethanol elution, eluent is concentrated and dried to powder；
B weighs residual drug in composition according to parts by weight, is positioned in 60 DEG C of baking ovens and dries 30min, is ground into
1cm2, be soaked in water 0.5h, with the water ultrasonic extraction 3h of 10 times of amounts, filtering, and 6 times of water refluxing extractions 3 times measured of residue, every time
30min, merge each secondary filtrate, concentration, dry to powder；
The dried powder that c combining steps a and step b is obtained is well mixed, and produces the composition.
The granule of embodiment 9
Granule is composed of the following components in parts by weight:
The granule of embodiment 10
Granule is composed of the following components in parts by weight:
The granule of embodiment 11
Granule is composed of the following components in parts by weight:
Reference examples 1
It is in place of a kind of composition, with the difference of embodiment 2, adds the tuber of dwarf lilyturf that parts by weight are 5.
Reference examples 2
It is in place of a kind of composition, with the difference of embodiment 2, turmeric is instead of with Ligusticum wallichii.
Reference examples 3
It is in place of a kind of composition, with the difference of embodiment 2, deletes radix cynanchi bungei.
Reference examples 4
It is in place of a kind of composition, with the difference of embodiment 6, adds the capsule of weeping forsythia that parts by weight are 10.
Reference examples 5
It is in place of a kind of composition, with the difference of embodiment 6, seabed coconut is instead of with levisticum.
Reference examples 6
It is in place of a kind of composition, with the difference of embodiment 6, deletes hippocampus and do.
The granule of reference examples 7
It is in place of a kind of granule, with the difference of embodiment 10, adds 2.5 parts of mannitol.
The granule of reference examples 8
It is in place of a kind of granule, with the difference of embodiment 10, polyvinylpyrrolidone is instead of with Tween-80.
The granule of reference examples 9
It is in place of a kind of granule, with the difference of embodiment 10, deletes polyoxyethylene monoester acid esters.
The effect of test example 1 compares
1. high fat of blood animal model:
SD rats, after adaptability is raised one week, it is randomly divided into model control group, normal group, 1 group of experiment, 2 groups of experiment, examination
Test 3 groups of example, 4 groups of test example, 1 group of control, 2 groups of control, control group 3, reference examples 4 and positive controls；Test 1 group and use this hair
The composition of bright embodiment 2,2 groups of compositions for using the embodiment of the present invention 4 of experiment, 3 groups of experiment use the embodiment of the present invention 5
Composition, 4 groups of compositions for using the embodiment of the present invention 6 of experiment, 5 groups of compositions for using the embodiment of the present invention 7 of embodiment are real
6 groups of compositions for using the embodiment of the present invention 8 of example, 1 group of composition for using reference examples 2 of control are applied, 2 groups of control uses reference examples
4 composition, 3 groups of compositions for using reference examples 5 of control, 4 groups of compositions for using reference examples 6 of control；Every group 6, experiment
The dosage of group and control group is 0.85g.kg-1.d-1, normal group gives isometric physiological saline with model group, common to be administered
12 weeks.
2. the measure of lipids contents
Each group animal is in the 0th week and the 12nd week all 4 mornings 9 of experiment:00 eye socket takes blood, and it is always sweet to determine blood plasma after separated plasma
Oily three esters, T-CHOL, low-density lipoprotein cholesterol level, the results are shown in Table 1.
Therapeutic effect of the 1 each composition of table to high fat of blood
3. conclusion
As shown in Table 1, the composition that the embodiment of the present invention 2, embodiment 4-8 are provided has significant to the high fat of blood of mouse
Therapeutic effect, and it is better than reference examples 2, reference examples 4-6 compositions to the therapeutic effect of hyperlipemia, it was demonstrated that provided by the invention group
Compound has the effect of fine to high fat of blood, when the bulk drug in composition provided by the invention is reduced or is replaced by other
After bulk drug, said composition significantly reduces to the therapeutic effect of high fat of blood, and is better than the effect of embodiment 8
Embodiment 6, it was demonstrated that the preparation method of composition provided by the invention is higher to the extraction efficiency of composition, to high blood
The therapeutic effect of fat is more preferable.
The melting of test example 2 is tested
Example 9-11 and reference examples 7-9 granule 10g, water 200ml is heated, stir and to observe granule completely molten
The time of change, it the results are shown in Table 2；
The melting result of the test of table 2
Version in 2015《Chinese Pharmacopoeia》Middle regulation, the agent of 5min endoparticles should all dissolve or slight haze, can from table
Go out, it is fine to add sorbitan fatty acid ester, polyoxyethylene monoester acid esters, polyvinylpyrrolidone and crystallite provided by the invention
After dimension element, all granules dissolve in 3min, greatly improve the melting of granule, shorten its solution time,
And then can more quick and sweetener be dissolved in the water to form liquid beverage.
Claims (9)
1. a kind of composition for being used to treat high fat of blood, it is characterised in that the composition is mainly by the raw material of following parts by weight
It is prepared:
2. the composition as claimed in claim 1 for being used to treat high fat of blood, it is characterised in that the composition also includes weight
Number is that 5-30 seabed coconut and 10-20 hippocampus do.
3. the composition as claimed in claim 1 for being used to treat high fat of blood, it is characterised in that the composition is by following weight
The raw material of part is prepared:
4. the composition as claimed in claim 1 for being used to treat high fat of blood, it is characterised in that the composition is by the following method
It is prepared:
1) after each material is weighed in proportion, be soaked in water 1-3h respectively；
2) raw material after soaking is taken, is boiled 3 times with decocting, each amount of water is 8-12 times of raw material gross weight, decocts 2-4h, mistake every time
Merging filtrate after filter, take 75% alcohol reflux of 2-3 times of weight of filter residue filter residue to extract 2h, obtain decocting liquid, then by filtrate with decocting
Liquid merges, and filters, and concentration, dries to powder, produces the composition.
A kind of 5. preparation method for being used to treat the composition of high fat of blood as claimed in claim 1, it is characterised in that the preparation
Method specifically comprises the following steps:
A weighs emblic, radix polygonati officinalis and turmeric according to parts by weight, is decocted 3 times with the pressurization of 65% ethanol solution, adds ethanol for the first time
Measure as 5 times of bulk drug gross weight, decoct 1h, for the second time plus amount of alcohol is 4 times of bulk drug gross weight, decocts 1.5h, third time adds
Amount of alcohol is 4 times of bulk drug gross weight, decocts 0.5h, merges each secondary filtrate, is filtered, and concentration, macroreticular resin on concentrate is inhaled
It is attached, with 72% ethanol elution, eluent is concentrated and dried to powder；
B weighs residual drug in composition according to parts by weight, is positioned in 60 DEG C of baking ovens and dries 30min, is ground into 1cm2, use
Water soaks 0.5h, with the water ultrasonic extraction 3h of 10 times of amounts, filters, the water refluxing extractions 3 times, each 30min of 6 times of amounts of residue,
Merge each secondary filtrate, concentrate, dry to powder；
C combining steps 1) and step 2) obtain dried powder be well mixed, produce the composition.
A kind of 6. granule, it is characterised in that the granule include claim any one of 1-3 described in be used for treat high blood
The composition and auxiliary material of fat, the ratio of weight and number of the composition and auxiliary material is 1:2-5.
7. granule as claimed in claim 6, it is characterised in that the auxiliary material includes the Sorbitan that parts by weight are 2-5
Polyoxyethylene monoester acid esters, 2-5 polyvinylpyrrolidone and the 4-8 microcrystalline cellulose of alcohol fatty acid ester, 1-10.
8. a kind of solid beverage, including granule, sweetener and water described in claim 6, it is characterised in that described particle
The ratio of weight and number of agent, sweetener and water is 2:0.1-0.5:1-1.5.
9. the answering in preparing for the product for the treatment of or auxiliary treatment high fat of blood of the composition described in claim any one of 1-3
With.
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