CN100469377C - Nankang soft capsule for treating prostatitis - Google Patents
Nankang soft capsule for treating prostatitis Download PDFInfo
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- CN100469377C CN100469377C CNB2006100867002A CN200610086700A CN100469377C CN 100469377 C CN100469377 C CN 100469377C CN B2006100867002 A CNB2006100867002 A CN B2006100867002A CN 200610086700 A CN200610086700 A CN 200610086700A CN 100469377 C CN100469377 C CN 100469377C
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Abstract
A Chinese medicine 'Nankang softgel' for treating prostatitis is prepared from 19 Chinese-medicinal materials including dandelion herb, epimedium, dodder seed, astragalus root, etc.
Description
Technical field:
The present invention relates to the prostatitic Chinese medicine preparation of a kind of treatment, particularly relate to the modified form of NANKANG soft capsule, this soft capsule is that 19 flavor Chinese medicines are formulated through processing.
Background technology:
The NANKANG soft capsule is to come through changing dosage form on the basis of NANKANG PIAN, and NANKANG PIAN is the treatment medicine that is used for chronic prostatitis, has the kidney invigorating and essence nourishing, blood circulation promoting and blood stasis dispelling, the effect of eliminating damp, detoxifying.Be used for the treatment of deficiency of the kidney, the chronic prostatitis that stagnation of blood stasis, damp-heat accumulation cause is sold on market at present.
Because the tablet drug release rate is slower, bioavailability is lower, clinical reflection curative effect instability.Soft capsule is that active constituents of medicine is dissolved in the liquid solvent, its liquid back that becomes uniformity is filled in the capsule as content, every capsules contained drug error is little, simultaneously, medicine is made soft capsule after dissolving can obtain good blood drug level, drug release is very fast, and bioavailability is good, so be well positioned to meet the medication requirement.In addition, soft capsule has plasticity and elasticity, can moistureproof, anti-oxidation, lucifuge, and can improve stability of drug; Dosage accurately, carry and easy to use; Exquisite appearance is subject to patient and accepts.
Summary of the invention:
The invention provides a kind of NANKANG soft capsule preparation, this soft capsule is made up of the material of active constituents of medicine and pharmaceutically useful adjuvant and manufacturing soft capsule shell.
Described active constituents of medicine is identical with NANKANG PIAN, is processed into through extracting by 19 kinds of Chinese medicines.
Described pharmaceutically useful adjuvant is selected from, PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, soybean oil, dehydrogenation soybean oil, vegetable oil, aromatic oil, and Cera Flava etc., preferred adjuvant is soybean oil and mellisic mixture.
The material of described manufacturing soft capsule shell is gelatin or arabic gum, water, and plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0:0.4～1.0 in the soft capsule shell, the weight ratio of gelatin and water is 1.0:0.8～1.2.
Soft capsule of the present invention, its soft capsule content are by active constituents of medicine, and soybean oil and mellisic mixture are formed, and the preferred proportioning of content is as follows:
Active constituents of medicine 50-200g soybean oil 100-400g Cera Flava 3-20g
Most preferredly be:
Active constituents of medicine 100g soybean oil 200g Cera Flava 8g makes 1000
Above proportion raw material can be made into 1000 of soft capsule preparations.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be a unit with gram or milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Active constituents of medicine in the soft capsule of the present invention can prepare by the following method:
Active constituents of medicine of the present invention is that the Chinese medicine with following prescription is that raw material obtains by extracting processing, and extracting method can use any of prior art, as the technology in Chinese Pharmacopoeia or the drug standard, or patented technology, or the technology in the textbook.As obtaining by extracting raw material of Chinese medicine respectively, also can obtain by co-extracted raw material of Chinese medicine medical material, also can obtain by other modes, as: by pulverize, squeeze, grind, sieve, method such as percolation, extraction, water are carried, alcohol extraction, ester are carried, macroporous adsorption resin chromatography obtains, these active component can be the material of extractum form, can be that dry extract also can be a fluid extract, also can be volatile oil.
Prescription of the present invention is composed as follows:
Herba Taraxaci 120-480g Herba Epimedii 80-320g Herba Hedyotidis Diffusae 120-480g Herba Patriniae 80-320g
Herba Houttuyniae 80-320g Herba Pyrolae 80-320g Herba Violae 80-320g Radix Rehmanniae Preparata 48-192g
Cortex Phellodendri 40-160g Semen Cuscutae 40-160g Herba Cistanches 48-192g Fructus Rubi 80-320g
Flos Chrysanthemi Indici 48-192g Radix Astragali 40-160g Rhizoma Atractylodis Macrocephalae 40-160g Radix Angelicae Sinensis 40-160g
Radix Paeoniae Rubra 40-160g Flos Carthami 16-64g Radix Glycyrrhizae Preparata 24-96g.
Preferred prescription of the present invention is composed as follows:
Active constituents of medicine of the present invention, preferred method for making is as follows:
More than 19 flavors, half amount of getting the Radix Astragali, Radix Paeoniae Rubra is ground into fine powder; The five tastes such as Herba Patriniae, Herba Houttuyniae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Flos Chrysanthemi Indici extract volatile oil with the way of distillation, and the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Astragali, 12 flavors such as second half amount of Radix Paeoniae Rubra and all the other Herba Taraxacis decoct with water three times, 1 hour for the first time, for the second time and each 0.5 hour for the third time, collecting decoction adds the aqueous solution after the above-mentioned distillation, filter, filtrate is by the macroporous adsorbent resin separation and purification, or directly is concentrated into relative density and is about 1.08 (90～95 ℃ time), after waiting to be chilled to room temperature, adding ethanol makes and contains alcohol amount and reach 75%, leave standstill, get the thick paste that supernatant concentration to relative density is 1.20～1.24 (75 ℃), add the Radix Astragali, the fine powder of Radix Paeoniae Rubra, mixing, drying is pulverized, and crosses 100 mesh sieves and becomes fine powder, spray into volatile oil, get active constituents of medicine of the present invention.
With active constituents of medicine of the present invention is that raw material and pharmaceutically useful adjuvant of the present invention mix, both content of the present invention; Described mixing may further comprise the steps:
The preparation of content substrate and content, being prepared as follows of wherein said content substrate: earlier with stabilizing agent Cera Flava (account for soybean oil ratio 3.0～5.0%) thermosol in soybean oil, stir, content substrate.Being prepared as follows of described content: the thing active component of getting it filled, in the prescription ratio (active constituents of medicine: content substrate=1:2～3) that feeds intake.Active constituents of medicine is added in the content substrate, stirs, cross then colloid mill pulverize content.
The rubber of soft capsule of the present invention can prepare with following method:
Other gets gelatin, glycerol, water (gelatin: glycerol: water=1.0:0.4:1.0), put and be heated to 80 ℃ of dissolvings in the appropriate vessel, filter, add antiseptic mud pool tortoise beetle ester and mud moor gold ethyl ester (ratio respectively be rubber total amount 0.08%) in the solution, mixing, in 60 ℃ be incubated rubber solution.
The invention described above content and rubber solution are prepared into soft capsule preparation of the present invention with the technology of galenic pharmacy routine, as with die pressing production or revolving die formula soft capsule maker production molding, after the drying promptly.
Prescription of the present invention is that different adjuvants is screened with preparation technology, by result of the test, preferably comes out, and the present invention's composition of preferably filling a prescription particularly, best results is the most stable.
The most preferred prescription of the present invention is listed in the embodiment of the invention.
Capsule of the present invention has been carried out study on the stability, its character, inspection, discriminating, active constituent content and microbial limit have been carried out investigating test, result of the test shows, this product under above-mentioned experimental condition, stable in properties, every index does not have significant change.
Soft capsule production technology of the present invention is reasonable, quality controllable, stable in properties.Soft capsule of the present invention has improved bioavailability of medicament, has strengthened the curative effect of medicine, the particularly the present invention composition of preferably filling a prescription, and has good especially stability and bioavailability.
The specific embodiment:
Further specify the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
The preparation of active component:
Method for making is as follows
More than 19 flavors, half amount of getting the Radix Astragali, Radix Paeoniae Rubra is ground into fine powder; The five tastes such as Herba Patriniae, Herba Houttuyniae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Flos Chrysanthemi Indici extract volatile oil with the way of distillation, and the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Astragali, 12 flavors such as second half amount of Radix Paeoniae Rubra and all the other Herba Taraxacis decoct with water three times, 1 hour for the first time, for the second time and each 0.5 hour for the third time, collecting decoction adds the aqueous solution after the above-mentioned distillation, filter, filtrate is by the macroporous adsorbent resin separation and purification, or directly is concentrated into relative density and is about 1.08 (90～95 ℃ time), after waiting to be chilled to room temperature, adding ethanol makes and contains alcohol amount and reach 75%, leave standstill, get the thick paste that supernatant concentration to relative density is 1.20～1.24 (75 ℃), add the Radix Astragali, the fine powder of Radix Paeoniae Rubra, mixing, drying is pulverized, and crosses 100 mesh sieves and becomes fine powder, spray into volatile oil, get active constituents of medicine of the present invention.
Embodiment 2
Preparation of soft capsule:
Active constituents of medicine 100g soybean oil 200g Cera Flava 8g makes 1000
Preparation: elder generation in soybean oil, stirs the Cera Flava thermosol, gets content substrate.The thing active component of getting it filled feeds intake in the prescription ratio.Active constituents of medicine is added in the content substrate, stirs, cross then colloid mill pulverize content.The compacting soft capsule, drying is made 1000, promptly.
Embodiment 3
Preparation of soft capsule:
Active constituents of medicine 100g soybean oil 300g Cera Flava 9g makes 1000
Preparation: elder generation in soybean oil, stirs the Cera Flava thermosol, gets content substrate.The thing active component of getting it filled feeds intake in the prescription ratio.Active constituents of medicine is added in the content substrate, stirs, cross then colloid mill pulverize content.The compacting soft capsule, drying is made 1000, promptly.
Embodiment 4
Preparation of soft capsule:
Active constituents of medicine 100g soybean oil 250g Cera Flava 10g makes 1000
Preparation: elder generation in soybean oil, stirs the Cera Flava thermosol, gets content substrate.The thing active component of getting it filled feeds intake in the prescription ratio.Active constituents of medicine is added in the content substrate, stirs, cross then colloid mill pulverize content.The compacting soft capsule, drying is made 1000, promptly.
Embodiment 5
Preparation of soft capsule:
Active constituents of medicine 50g PEG400 100g propylene glycol 15g of the present invention makes 1000
Get active constituents of medicine of the present invention, add in the PEG400, stir and make dissolving, add propylene glycol, mixing, the compacting soft capsule, drying is made 1000, promptly.
Embodiment 6
The preparation of active component:
Method for making is as follows
More than 19 flavors, half amount of getting the Radix Astragali, Radix Paeoniae Rubra is ground into fine powder; The five tastes such as Herba Patriniae, Herba Houttuyniae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Flos Chrysanthemi Indici extract volatile oil with the way of distillation, and the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Astragali, 12 flavors such as second half amount of Radix Paeoniae Rubra and all the other Herba Taraxacis decoct with water three times, 1 hour for the first time, for the second time and each 0.5 hour for the third time, collecting decoction adds the aqueous solution after the above-mentioned distillation, filter, filtrate is by the macroporous adsorbent resin separation and purification, or directly is concentrated into relative density and is about 1.08 (90～95 ℃ time), after waiting to be chilled to room temperature, adding ethanol makes and contains alcohol amount and reach 75%, leave standstill, get the thick paste that supernatant concentration to relative density is 1.20～1.24 (75 ℃), add the Radix Astragali, the fine powder of Radix Paeoniae Rubra, mixing, drying is pulverized, and crosses 100 mesh sieves and becomes fine powder, spray into volatile oil, get active constituents of medicine of the present invention.
Embodiment 7
The preparation of active component:
Method for making is as follows
More than 19 flavors, half amount of getting the Radix Astragali, Radix Paeoniae Rubra is ground into fine powder; The five tastes such as Herba Patriniae, Herba Houttuyniae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Flos Chrysanthemi Indici extract volatile oil with the way of distillation, and the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Astragali, 12 flavors such as second half amount of Radix Paeoniae Rubra and all the other Herba Taraxacis decoct with water three times, 1 hour for the first time, for the second time and each 0.5 hour for the third time, collecting decoction adds the aqueous solution after the above-mentioned distillation, filter, filtrate is by the macroporous adsorbent resin separation and purification, or directly is concentrated into relative density and is about 1.08 (90～95 ℃ time), after waiting to be chilled to room temperature, adding ethanol makes and contains alcohol amount and reach 75%, leave standstill, get the thick paste that supernatant concentration to relative density is 1.20～1.24 (75 ℃), add the Radix Astragali, the fine powder of Radix Paeoniae Rubra, mixing, drying is pulverized, and crosses 100 mesh sieves and becomes fine powder, spray into volatile oil, get active constituents of medicine of the present invention.
Embodiment 8
The preparation of active component:
It is identical with embodiment 1 to fill a prescription.
Method for making is as follows
More than 19 flavors, the five tastes such as Herba Patriniae, Herba Houttuyniae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Flos Chrysanthemi Indici extract volatile oil with the way of distillation, the aqueous solution after the distillation in addition device is collected; The medicinal residues and the Radix Astragali, Radix Paeoniae Rubra, 12 flavors such as Herba Taraxaci decoct with water three times, 1 hour for the first time, reach each 0.5 hour for the third time for the second time, collecting decoction adds the aqueous solution after the above-mentioned distillation, filters, filtrate is by the macroporous adsorbent resin separation and purification, or directly be concentrated into relative density and be about 1.08 (90～95 ℃ time), after waiting to be chilled to room temperature, add ethanol and make and contain the alcohol amount and reach 75%, leave standstill, get the thick paste that supernatant concentration to relative density is 1.20～1.24 (75 ℃), mixing, drying, pulverize, cross 100 mesh sieves and become fine powder, spray into volatile oil, get active constituents of medicine of the present invention.
Claims (10)
1, the prostatitic soft capsule of a kind of treatment, it is characterized in that this soft capsule is by content active constituents of medicine and pharmaceutically useful adjuvant, and the material composition of making soft capsule shell, the pharmaceutically active substance of wherein said soft capsule processes for the Chinese medicine process with following prescription
Herba Taraxaci 120-480g Herba Epimedii 80-320g Herba Hedyotidis Diffusae 120-480g Herba Patriniae 80-320g
Herba Houttuyniae 80-320g Herba Pyrolae 80-320g Herba Violae 80-320g Radix Rehmanniae Preparata 48-192g
Cortex Phellodendri 40-160g Semen Cuscutae 40-160g Herba Cistanches 48-192g Fructus Rubi 80-320g
Flos Chrysanthemi Indici 48-192g Radix Astragali 40-160g Rhizoma Atractylodis Macrocephalae 40-160g Radix Angelicae Sinensis 40-160g
Radix Paeoniae Rubra 40-160g Flos Carthami 16-64g Radix Glycyrrhizae Preparata 24-96g.
2, the soft capsule of claim 1 is characterized in that, the pharmaceutically active substance of this soft capsule processes for the Chinese medicine process with following prescription,
Herba Taraxaci 240g Herba Epimedii 160g Herba Hedyotidis Diffusae 240g Herba Patriniae 160g
Herba Houttuyniae 160g Herba Pyrolae 160g Herba Violae 160g Radix Rehmanniae Preparata 96g
Cortex Phellodendri 80g Semen Cuscutae 80g Herba Cistanches 96g Fructus Rubi 160g
Flos Chrysanthemi Indici 96g Radix Astragali 80g Rhizoma Atractylodis Macrocephalae 80g Radix Angelicae Sinensis 80g
Radix Paeoniae Rubra 80g Flos Carthami 32g Radix Glycyrrhizae Preparata 48g.
3, the soft capsule of claim 1 is characterized in that, described pharmaceutically useful adjuvant is selected from: PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, soybean oil, dehydrogenation soybean oil, aromatic oil and Cera Flava.
4, the soft capsule of claim 1 is characterized in that, its content active constituents of medicine and pharmaceutically useful adjuvant are composed as follows:
Active constituents of medicine 50-200g adjuvant 100-500g
Wherein said pharmaceutically useful adjuvant is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, soybean oil, dehydrogenation soybean oil, aromatic oil and Cera Flava.
5, the soft capsule of claim 1 is characterized in that, its content active constituents of medicine and pharmaceutically useful adjuvant are composed as follows:
Active constituents of medicine 50-200g soybean oil 100-400g Cera Flava 3-20g.
6, the soft capsule of claim 1 is characterized in that, its content active constituents of medicine and pharmaceutically useful adjuvant are composed as follows:
Active constituents of medicine 100g soybean oil 200g Cera Flava 8g.
7, the soft capsule of claim 1 is characterized in that, its content active constituents of medicine and pharmaceutically useful adjuvant are composed as follows:
Active constituents of medicine 100g soybean oil 300g Cera Flava 9g.
8, the soft capsule of claim 1 is characterized in that, its content active constituents of medicine and pharmaceutically useful adjuvant are composed as follows:
Active constituents of medicine 100g PEG400 100g propylene glycol 15g.
9, the preparation of soft capsule method of claim 1: it is characterized in that, through following steps
1) preparation of content substrate: elder generation in soybean oil, stirs the Cera Flava thermosol, gets content substrate;
2) preparation of content: the thing active component of getting it filled, feed intake in the prescription ratio, active constituents of medicine is added in the content substrate, stir, cross then colloid mill pulverize content;
3) die pressing production or revolving die formula soft capsule maker production molding, after the drying promptly;
Wherein active constituents of medicine is by extracting respectively or co-extracted raw material of Chinese medicine medical material obtains, or by pulverize, squeeze, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, the macroporous adsorption resin chromatography method obtains.
10, the preparation method of claim 9: step 2 wherein) described active constituents of medicine preparation method is as follows:
Half amount of getting the Radix Astragali, Radix Paeoniae Rubra is ground into fine powder; Herba Patriniae, Herba Houttuyniae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and the Flos Chrysanthemi Indici five tastes extract volatile oil with the way of distillation, and the aqueous solution after distillation device is in addition collected; The medicinal residues and the Radix Astragali, second half amount of Radix Paeoniae Rubra and all the other 12 flavors decoct with water three times, 1 hour for the first time, for the second time and each 0.5 hour for the third time, collecting decoction adds the aqueous solution after the above-mentioned distillation, filter, filtrate is by the macroporous adsorbent resin separation and purification, or directly is concentrated into relative density and is about 1.08, after waiting to be chilled to room temperature, adding ethanol makes and contains alcohol amount and reach 75%, leave standstill, get supernatant concentration to relative density and be 1.20～1.24 thick paste, add the Radix Astragali, the fine powder of Radix Paeoniae Rubra, mixing, drying is pulverized, and crosses 100 mesh sieves and becomes fine powder, spray into volatile oil, get active constituents of medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100867002A CN100469377C (en) | 2006-06-29 | 2006-06-29 | Nankang soft capsule for treating prostatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100867002A CN100469377C (en) | 2006-06-29 | 2006-06-29 | Nankang soft capsule for treating prostatitis |
Publications (2)
| Publication Number | Publication Date |
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| CN1895462A CN1895462A (en) | 2007-01-17 |
| CN100469377C true CN100469377C (en) | 2009-03-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006100867002A Expired - Fee Related CN100469377C (en) | 2006-06-29 | 2006-06-29 | Nankang soft capsule for treating prostatitis |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100345568C (en) * | 2006-06-30 | 2007-10-31 | 王连喜 | Chinese-medicinal preparation for treating prostatic disease |
| WO2008113118A1 (en) * | 2007-03-16 | 2008-09-25 | Medcina Group Pty Ltd | Compositions and methods for treating male infertility |
| CN101766734B (en) * | 2008-12-30 | 2011-07-27 | 胡翠华 | Medicine for treating prostatitis |
| CN105148135A (en) * | 2015-10-08 | 2015-12-16 | 温州医科大学附属第一医院 | Traditional Chinese medicine preparation for treating chronic prostatitis |
| CN105616806A (en) * | 2016-02-27 | 2016-06-01 | 刘芳 | Traditional Chinese medicine composition for treating prostatitis |
| CN106038836A (en) * | 2016-07-28 | 2016-10-26 | 黄春荣 | Traditional Chinese medicinal composition for treating prostatitis |
-
2006
- 2006-06-29 CN CNB2006100867002A patent/CN100469377C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 中药成方制剂. 卫生部药典委员会，137. 1998 |
| 中药成方制剂. 卫生部药典委员会，137. 1998 * |
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