CN104666643B - A kind of compound snow chrysanthemum product and its preparation method and application - Google Patents
A kind of compound snow chrysanthemum product and its preparation method and application Download PDFInfo
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Abstract
The present invention relates to a kind of compound snow chrysanthemum products and its preparation method and application, it calculates by weight, the compound snow chrysanthemum product use parts by weight for 0.8-6 parts of snow chrysanthemum, 0.8-6 parts of Ilex Latifolia Thunb, 0.5-4 parts of vine tea, 0.2-2 parts of STEVIA REBAUDIANA raw material, with other edible or pharmaceutic adjuvants, drug, health care product or food is made according to the method for the present invention.Compound snow chrysanthemum products application of the invention achieves good therapeutic effect when the symptoms such as hypertension, hyperlipidemia and hyperglycemia, has many advantages, such as stable, efficient, safe, and preparation process is simple, is suitable for industrialized production.
Description
Technical field
The invention belongs to Chinese medicines, health product technology field, relate in particular to compound snow chrysanthemum product and preparation method thereof and answer
With.
Background technique
" three high diseases " refer to hypertension, hyperglycemia (diabetes) and hyperlipidemia.They are that modern society is derived from
" rich people's disease ", possible individualism, it is also possible to interrelated.Such as: diabetes patient is easy to suffer from hypertension or high blood simultaneously
Rouge disease, and hyperlipidemia is the principal element of artery sclerosis formation and development, arteriosclerotic's blood vessel elasticity difference aggravates blood pressure
It increases.So there are any one of these three illness, the later period all easily forms " three high diseases ".With mentioning for living standard
High and rhythm of life change, referred to as " three high diseases " (i.e. hypertension, hyperglycemia and the hyperlipidemia) of " rich people's disease ", it has also become 50
Year old or more middle-aged and the old's health common disease, the number that cardiovascular and cerebrovascular disease is died of in the whole world every year is up to 15,000,000 people, occupies each
The kind cause of the death is the first.In the ten big causes of death of Chinese, the death rate relevant to metabolic disease is as high as 35.7%, with " three
The relevant death toll of height " also accounts for the 27% of total death toll.The World Health Organization once clearly proposed, prevented cardiovascular disease
The first line of defence is exactly to reduce " three high " and control " three high ".
Chrysanthemum is the dry capitulum of compositae plant chrysanthemum Chrysanthemum morifolium Ramat., sweet, bitter,
It is slightly cold, there is the effect of relieve heat heat-clearing, calming the liver and improving eyesight.There are many type of chrysanthemum, and different chrysanthemums has certain in terms of medicinal efficacy
Difference, for example chu chrysanthemum is clearing heat and detoxicating, relaxing tendons and activating collaterals, liver protection and eyesight, and feverfew clears liver and improve vision, yellow chrysanthemum wind-dispelling heat-dissipating, mother chrysanthemum heat-clearing
Removing toxic substances, STEVIA REBAUDIANA pressure regulation, lipid-loweringing, hypoglycemic, snow chrysanthemum removing toxic substances dampness elimination etc..Therefore, suitable chrysanthemum type is selected, reasonable medicine of arranging in pairs or groups
Material can be only achieved the effect got twice the result with half the effort for specific health purpose.
In the prior art, have much using chrysanthemum as the report of health product, wherein preventing and treating hypertension, high blood
Rouge or the pertinent literature of hyperglycemia are quite a few, as patent CN201110451691.3 discloses a kind of compound health-care containing vine tea
Tea and preparation method thereof is to be prepared jointly with the leaf of vine tea, stem branch and chrysanthemum, mulberry leaf, lotus leaf, but the invention is mainly dashed forward
The effect of aobvious vine tea tender leaf and stem branch, wherein the dosage of chrysanthemum is seldom, and does not indicate which kind of chrysanthemum is best medicinal ingredient；Specially
Benefit application CN201410628445.4 discloses a kind of Ilex Latifolia Thunb grape wine and preparation method thereof, using grape wine activating microcirculation and removing stasis medicinal it
Effect, the medicinal materials such as collocation Ilex Latifolia Thunb, Gegen tablets, hawthorn, sweetleaf inulin, rush, dark plum reach the stagnation resolvation that heals, promoting blood circulation decompression
Purpose, the health wine of the invention provides the another selection of alcohol product for consumer；Patent application
CN201310658985.2 discloses Chinese medicine composition of blood pressure lowering and preparation method thereof, and the composition is by fructus arctii, bluish dogbane, snow
12 kinds of medicinal materials such as chrysanthemum, Ilex Latifolia Thunb, corn stigma, herba taxilli are made, the invention crude drug complicated composition, and in reducing blood lipid, hypoglycemic side
Face fails to obtain ideal effect.
Although having very much, simultaneously for hypertension, the Chinese and western drugs of hyperlipidemia and hyperglycemia and health product at present
It is less to the medicable registration of " three high ", wherein less merely with product made of snow chrysanthemum and other Chinese medicines.The present invention is ground
Studying carefully personnel with snow chrysanthemum is to eliminate three high basic raw materials, the shared medicine with other kinds of chrysanthemum, tealeaves and part medicine food
Material has carried out conscientious careful screening study, has in the hope of bringing for many patients in lowering blood pressure and blood fat and hypoglycemic aspect
There are safe and efficient, and dosage form multiplicity, the product that uses for different crowd.At present have no using snow chrysanthemum, vine tea, Ilex Latifolia Thunb and
Composition or compound preparation made of STEVIA REBAUDIANA and its relevant report for reducing " three high " simultaneously.
Summary of the invention
The object of the present invention is to provide a kind of compositions simply, active constituent utilization rate is high, product type multiplicity compound snow
Chrysanthemum product and preparation method thereof, and preparation have lowering blood pressure and blood fat and the hypoglycemic three drops drug of function, health care product or
Application in terms of food.
The present invention is implemented as follows:
A kind of compound snow chrysanthemum product, which is characterized in that the product is made of raw material from the following weight: snow chrysanthemum 0.8-6
Part, 0.8-6 parts of Ilex Latifolia Thunb, 0.5-4 parts of vine tea, 0.2-2 parts of STEVIA REBAUDIANA.
Further, the parts by weight of raw materials of the product are as follows: 1.5-3 parts of snow chrysanthemum, 1.5-3 parts of Ilex Latifolia Thunb, 1-2 parts of vine tea,
0.5-1 parts of STEVIA REBAUDIANA.
Compound snow chrysanthemum product above-mentioned can be drug, health care product or food.
Further, the dosage form of the drug or health care product is tablet, capsule, granule or oral solution；The food
Type be tea beverage, tea bag.
The invention also discloses the preparation methods of compound snow chrysanthemum product.
Wherein, the preparation method of drug or health care product the following steps are included:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；What the dregs of a decoction and stevioside leaf were measured with 6-10 times
The alcohol reflux that concentration is 65%-100% extracts 1-3 times, 0.5-1.5 hours each, and extracting solution filtering, filtrate merges, concentration
It is formed in the medicinal extract that relative density at 55-60 DEG C is 1.15-1.30；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filter
Liquid merges, and concentration is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, spray drying or directly add
Enter extracted snow chrysanthemum volatile oil, adds pharmaceutic adjuvant, required tablet, capsule, granule, oral solution is made.
Specifically, tablet is prepared:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；What the dregs of a decoction and stevioside leaf were measured with 6-10 times
The alcohol reflux that concentration is 20%-50% extracts 1-3 times, 0.5-1.5 hours each, and extracting solution filtering, filtrate merges, concentration system
At the medicinal extract that relative density is 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filter
Liquid merges, and concentration is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried,
The microcrystalline cellulose of tablet total amount 15-20% is added in medicinal powder after drying, remaining is supplemented to full dose with pregelatinized starch, is added
The snow chrysanthemum volatile oil collected, is mixed evenly, and is pelletized with 8% starch slurry, dry, and the stearic acid of tablet total amount 0.5-1% is added
Magnesium, tabletting to get.
Capsule is prepared:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；What the dregs of a decoction and stevioside leaf were measured with 6-10 times
The alcohol reflux that concentration is 20%-50% extracts 1-3 times, 0.5-1.5 hours each, and extracting solution filtering, filtrate merges, concentration system
At the medicinal extract that relative density is 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filter
Liquid merges, and concentration is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried,
The microcrystalline cellulose of capsule total amount 12-15% is added in medicinal powder after drying, remaining is supplemented to full dose with cornstarch, is added
The snow chrysanthemum volatile oil collected, is mixed evenly, and pelletizes, dry, and the magnesium stearate of total amount 0.5-1% is added, encapsulated after mixing,
To obtain the final product.
Granule is prepared:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；What the dregs of a decoction and stevioside leaf were measured with 6-10 times
The alcohol reflux that concentration is 20%-50% extracts 1-3 times, 0.5-1.5 hours each, and extracting solution filtering, filtrate merges, concentration system
At the medicinal extract that relative density is 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filter
Liquid merges, and concentration is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried,
Snow chrysanthemum volatile oil, the dextrin collected are added in medicinal powder after drying, mixes, pelletizes, dry, whole grain is packed to get particle
Agent.
Oral solution is prepared:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；What the dregs of a decoction and stevioside leaf were measured with 6-10 times
The alcohol reflux that concentration is 20%-50% extracts 1-3 times, 0.5-1.5 hours each, and extracting solution filtering, filtrate merges, concentration system
At the medicinal extract that relative density is 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filter
Liquid merges, and concentration is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, total amount is added water to
50%, the snow chrysanthemum volatile oil of collection is added, mixes, simple syrup adds to sugar content 15-20%, and 0.1% sodium benzoate is added, adds steaming
Distilled water mixes, filtering, encapsulating is to get oral solution to full dose.
Wherein, the preparation method of compound snow chrysanthemum tea beverage comprises the steps of:
1) snow chrysanthemum, stevioside leaf being crushed, the alcohol reflux that the concentration measured with 6-10 times is 20%-50% extracts 1-3 times,
0.5-1.5 hours every time, extracting solution filtering, filtrate merged, spare；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filter
Liquid merges, spare；
3) by extract solution made from step 1 and 2, add the chitosan of crude drug amount 1%, stand 24 hours, filtration, filtrate
Add water, stir evenly, adjust pH value to 4-5, is added the rock sugar of beverage total amount 6-9%, the citric acid of 0.05-0.12%, sterile filtration,
Filtrate packing, rolls lid, beverage is made.
Wherein the preparation method of compound snow chrysanthemum tea bag comprises the steps of:
1) snow chrysanthemum, the STEVIA REBAUDIANA of formula ratio are taken, water content is dried under vacuum at 0-6 DEG C less than 5%, is ground into fine powder, mistake
60 meshes are spare；
2) take the lectuce tea powder of formula ratio 50%-70% be broken into granularity be 0.2-0.3mm coarse powder, remaining Ilex Latifolia Thunb with match
The vine tea branches and leaves just measured, adding 6-10 times of amount, concentration is 55%-75% ethanol solution refluxing extraction 1-2 times, 1-2 hours each, is closed
And extracting solution, filtering, concentration are formed in the medicinal extract that relative density at 55-60 DEG C is 1.20-1.30；
3) frying pot is opened, adjusting temperature is 75-85 DEG C, and stirring rod speed is 80-120 revs/min, is put into Ilex Latifolia Thunb coarse powder
After stir-frying 10-20 minutes, extract medicinal extract made from the snow chrysanthemum powder and sweetleaf inulin and step 2) of addition step 1) is sufficiently mixed
After conjunction, mixture is put into sterilizing, drying equipment, first high-temperature sterilization, is then cooled to 80 DEG C rapidly hereinafter, low temperature drying, mistake
80 mesh sieves, packing to get.
It is yet another object of the invention to provide compound snow chrysanthemum products above-mentioned to have blood pressure lowering, hypoglycemic and drop blood in preparation
Application in functional product drops in rouge three.
Compared with prior art, the raw material that the present invention uses, effect are as follows with mechanism:
Snow chrysanthemum: also known as double-colored golden wave, coreopsis tinctoria, it is mild-natured, it is sweet in flavor.There is clearing heat and detoxicating, dampness elimination function.Originate in the U.S.
Central and west regions, western part of China cultivation, due to growing environment pollution less, height above sea level, containing to 18 kinds of beneficial amino acid of human body,
More than 30 kinds of Flavonoid substances and mineral element needed by human, there are also organic acid abundant, terpenes, vitamin, enzymes and more
Sugar has special efficacy to hypertension, hyperlipidemia, hyperglycemia, coronary heart disease etc., and triglyceride and the gallbladder that can be substantially reduced serum are solid
Alcohol, and have the effect of sterilization, anti-inflammatory, weight-reducing, preventing cold and chronic enteritis, also there is fairly good opsonic action for insomnia.
Wherein, general flavone content reaches 12%, considerably beyond other various chrysanthemum classes.
STEVIA REBAUDIANA: being a kind of perennial catananche, contains synanthrin glycosides in blade, sugariness be sucrose 150~
300 times, be a kind of fabulous natural sweetener.And certain diseases can be treated, such as control diabetes, blood pressure lowering, to obesity, the heart
Popular name for, children's worm tooth etc. are also effective in cure, and boost metabolism, the effect of strong body.Leaf contains stevioside
(Stevioside), steviolbioside (Steviolbioside), Stevioside A, B (rebaudisides A, B) isoreactivity ingredient
And sweet ingredient.Pharmacological testing shows that its effective component Stevia rebaudiana acid inhibits the synthesis of sugar and oxygen to absorb, under blood glucose level is obvious
Drop；In addition also there is obvious vasodilative effect, therefore have to blood pressure, softening blood vessel, reduction blood lipid, hypoglycemic, glucose in urine etc. is adjusted
Significant curative effect, and also have antibacterial hemostasis, analgesia, fat-reducing and beauty, nourishing Yin and promoting production of body fluid, help digest, promotion pancreas, spleen and stomach function and
Clearing heat and detoxicating effect.
Vine tea: also known as Maoyanmei tea, low grown oolong tea, long-lived rattan etc., scientific name ampelopsis grossdentata.Rich in 17 kinds of amino acid and potassium,
14 kinds of microelements such as calcium, iron, wherein effective component dihydromyricetin, anthocyanidin, flavones content are very high, anti-inflammatory with sterilization,
Clearing heat and detoxicating, analgesia detumescence, throat soothing cough-relieving, the functions such as improves the immunity of the human body at lipid-lowering pressure-reducing hypoglycemic.The health-care effect side of vine tea
Face, (drop blood is viscous, blood pressure lowering, hypoglycemic), three anti-(antithrombotic, anti-aging, antitumor), three, which are adjusted, thirdly drop (adjusts blood lipid, adjusts
Section is immune, adjusts stomach) effect it is significant.
Ilex Latifolia Thunb: Aquifoliaceae Ilex latifolia Thunb kind aiphyllium is commonly called as tea fourth, Fu Dingcha, highland Lu's tea, is mainly distributed on
Southwest, it is sweet in flavor, bitter, it is cold in nature, it is a kind of traditional pure natural health-care beverage good merchantable brand in China.Contain bitter leaves soap in Ilex Latifolia Thunb
200 Multiple components such as glucoside, amino acid, vitamin C, Polyphenols, flavonoids, caffeine, protein have reducing blood lipid, increase hat
Shape blood flow volume, increase myocardial blood supply, antiatherosclerosis the effects of, to the dizziness of Patients with Cardiovascular/Cerebrovascular Diseases, headache,
The symptoms such as uncomfortable in chest, out of strength, insomnia have preferable preventive and therapeutic effect.Its made tea faint scent has bitter taste, then sweet and cool-natured, disappears with heat-clearing
Heat, eyesight-improving intelligence-developing, promote the production of body fluid to quench thirst, diuresis heart tonifying, throat soothing cough-relieving, decompression weight-reducing, suppression cancer anti-cancer, anti-aging, the arteries and veins etc. of invigorating blood circulation it is a variety of
Effect.
To sum up, the present invention utilizes snow chrysanthemum removing toxic substances, dampness elimination, hence it is evident that the effect for reducing the triglyceride and cholesterol of serum is taken
Soften blood vessel, blood lipid-reducing blood sugar-decreasing with STEVIA REBAUDIANA, the drop of vine tea three, the three anti-, health-care efficacies of three conditions and Ilex Latifolia Thunb decompression heart tonifying,
Anti-ageing promoting blood circulation, each active constituent mutually cooperates with, common synergy, can effectively prevent and treat hypertension, hyperlipidemia and high blood
Sugar and its related metabolic diseases.
Below using test come further the present invention will be described:
Experiment 1, product of the present invention " three drops " effect test-recipe determination
1, test specimen
Test specimen: sample of the present invention: tablet, capsule and granule made of selection example 1,3,4,10,11, number
Sample 1-5；
Control sample 1: the extracting solution prepared according to patent application CN201310658985.2 embodiment 1, concentration are formed in
The medicinal extract that relative density is 1.20 at 60 DEG C；
Control sample 2: according to the tablet of the formula of embodiment 1 and preparation method preparation, wherein being free of STEVIA REBAUDIANA；
Control sample 3: according to the tablet of the formula of embodiment 1 and preparation method preparation, wherein vine tea is changed to pueraria lobata；
Control sample 4: according to the tablet of the formula of embodiment 1 and preparation method preparation, wherein Ilex Latifolia Thunb is changed to Keemun black tea.
2, test method
2.1 hypolipidemic pharmacological research
2.1.1 experimental animal
SD rat, weight 180-220g, half male and half female clean grade standard, are randomly divided into 12 groups: blank control group, model
Group, Diaoxinxue Kang group, sample 1-5 group, control sample 1-4 group, every group 10, sub-cage rearing.In addition to blank control group, remaining
After each group rat continuously gives high lipid food diet 14 days, plexus vasculosus takes blood after randomly selecting every group 30% of animal eyeball, inspection
Survey the blood lipid levels such as total cholesterol (TC), triglycerides (TG).As a result, compared with blank control group, high blood lipid model success rate
Reach 99%, it was demonstrated that modeling type is successfully, after rejecting the relatively low animal of individual blood lipid levels, to carry out fat-reducing medicament experiment.
2.1.3 test method
Model group and blank control group are normally fed after modeling, daily stomach-filling physiological saline 1ml, experimental group dosage are as follows:
Diaoxinxue Kang group 30mgkg-1；1,4,5 group of sample and contrast sample 2-4 group are all tablet, and 0.15gkg is administered-1；Sample
2 groups are capsule, and 0.1gkg is administered-1；3 groups of sample are granule, and 0.8gkg is administered-1；1 group of contrast sample is medicinal extract, is given
Medicine is equivalent to 7g crude drug kg-1；It is equivalent to 10 times of quantity.Finely ground, mixing before the above sample administration, is dissolved with distilled water and is made
Contain above-mentioned dosage part at every 1ml.
High lipid food, which is raised the about the 15th day, to be started to be administered, and is tested each animal groups and is administered orally respectively through stomach-filling, once a day
1ml, successive administration are total to surrounding 28 days (after the last administration, fasting can't help drinking 8h).All animals are taken a blood sample through eye socket, take serum, inspection
Survey blood lipid level after being administered.
2.2 hypoglycemic agent pharmacological research
2.2.1 experimental animal: NIH mouse, male, weight 18.0-23.1g clean grade standard.Take normal mouse tail vein
Inject alloxan (72mgkg-1), serum level of glucose is predicted after 72h, selects blood glucose value in 16mmolL-1The above person
It studies.It is randomly divided into 12 groups: blank control group, model group, sample 1-5 group, control sample 1-4 group, Metformin hydrochloride
(150mg·kg-1) group, every group 10, sub-cage rearing.
2.2.2 test method
Model group and blank control group are normally fed after modeling, daily stomach-filling physiological saline 1ml, experimental group dosage are as follows:
1,4,5 group of sample and contrast sample 2-4 group are all tablet, and 0.15gkg is administered-1；2 groups of sample are capsule, and 0.1g is administered
kg-1；3 groups of sample are granule, and 0.8gkg is administered-1；1 group of contrast sample is medicinal extract, is equivalent to 7g crude drug kg-1；It is equivalent to
10 times of quantity.It is finely ground before the administration of above sample, mix, every 1ml is made containing above-mentioned dosage part with distilled water dissolution, daily one
Secondary 1ml, continuous gavage are administered 7 days.1h after the last administration, mouse orbit veniplex measuring blood sugar of blood extracting are horizontal.
2.3 hypotensor pharmacological research
2.3.1 experimental animal: Wistar rat, male, 250 ± 26.3g of weight are randomly divided into 12 groups: control group (chlorination
Potassium), sample 1-5 group, control sample 1-4 group, Propranolol group, every group 10, sub-cage rearing.
2.3.2 test method: thorax artery myocardium vessel tension organon
2.3.2.1 the preparation and stabilization of aorta pectoralis vascular circle:
Rat sacrificed by decapitation opens chest and takes out aorta pectoralis rapidly, is placed in advance with mixed gas (95%O2And 5%CO2) full
In 4 DEG C of K-H liquid of sum, rinses to no bloodstain, carefully remove the adipose tissue and connective tissue of periphery, and be cut into 2-3mm
Vascular circle is placed in K-H liquid (the 37 DEG C of constant temperature, and be continually fed into 95%O for filling 10ml by long vascular circle2And 5%CO2Mixing
Gas, pH=7.4) constant temperature sleeve bottle in, each vascular circle two triangular forms hook runs through vascular circle lumen, and one end is solid
Fixed, the other end is connected to tension sensor, and tension variation is collected and recorded by BL-420E biological functional system.Vascular circle
Add rest tension 2g or so, stablizes 90min, during which the K-H fluid exchange liquid of every 15min pre-temperature to 37 DEG C.It is complete to vascular circle
After stablizing entirely, can formally it be tested.
2.3.2.2 to the influence of the pre-shrunk blood vessel ring strain of potassium chloride
After vascular circle is stablized, with KCl repetitive stimulation 3 times of 60mmol/L, the maximum shrinkage amplitude of blood vessel is induced, continuously
When the caused shrinkage amplitude difference of 3 same stimulations < 10%, with this as 100% shrink tension.Distinguish by 3 dosage of table
Trial drug is added.
3, result
3.1 reducing blood lipid test results
Through counting, lipid-lowering effect see the table below 1.
1 compound snow chrysanthemum product lipid-lowering effect of table
* P < 0.05 compared with contrast sample group,P < 0.05 compared with modeling group.
After the treatment of a course for the treatment of, sample sets and control sample group different level reduce total cholesterol (TC),
Triglycerides (TG) is horizontal.But it will be evident that sample of the present invention 1-3, that is, tablet, capsule and granule effect are best, hence it is evident that high
In Diaoxinxue Kang group therapeutic effect, illustrate compound snow chrysanthemum product curative effect affirmative of the invention；Compared with contrast sample 1-4 (i.e.
Lack medicinal material simply, or the collocation of replacement medicinal material), show to combine using prescription medicine of the invention, formula is reasonable；Low formula ratio system
At 4 groups of therapeutic effects of sample it is undesirable, 5 groups of curative effects of sample of high formula ratio indifference compared with sample 1-3 group, comprehensive medicinal material
Dosage, safety and economy etc., therefore select formulation dosage range of the invention.
3.2 hypoglycemic test results
Through counting, effect be see the table below.
2 compound snow chrysanthemum product blood sugar decreasing effect of table
* P < 0.05 compared with contrast sample group,P < 0.05 compared with modeling group.
After the treatment of 7d, sample sets and control sample group reduce the blood glucose level of model mice in various degree, but
It will be evident that sample 1-3, that is, tablet of the present invention, capsule and granule effect are best, hence it is evident that controlled higher than Metformin hydrochloride group
Therapeutic effect illustrates compound snow chrysanthemum product curative effect affirmative of the invention；(lack medicinal material simply, or more compared with contrast sample 1-4
The collocation of dressing material), show to combine using prescription medicine of the invention, formula is reasonable；4 groups for the treatment of effects of sample made of low formula ratio
Fruit is undesirable, 5 groups of curative effects of sample of high formula ratio indifference compared with sample 1-3 group, dosage, safety and the warp of comprehensive medicinal material
Ji property etc., therefore select formulation dosage range of the invention.
3.3 blood pressure lowering test results
Through counting, the effect of blood pressure lowering see the table below 3.
3 compound snow chrysanthemum product blood pressure lowering effect of table
The above result shows that sample sets and control sample group reduce the blood pressure level of model mice in various degree, but can
, it is evident that sample 1-3, that is, tablet of the present invention, capsule and granule effect are best, it is higher than Propranolol group therapeutic effect, explanation
Compound snow chrysanthemum product curative effect affirmative of the invention；(lack medicinal material simply, or replacement medicinal material is taken compared with contrast sample 1-4
With), show to combine using prescription medicine of the invention, formula is reasonable；4 groups of therapeutic effects of sample made of low formula ratio are paid no attention to
Think, 5 groups of curative effects of sample of high formula ratio indifference compared with sample 1-3 group, dosage, safety and the economy of comprehensive medicinal material
Deng, therefore select formulation dosage range of the invention.
Test 2, Study on Preparation
1, the preparation of drug or health care product:
The volatile oil of snow chrysanthemum is first collected by the present invention, avoids conventional method lacking merely with the medical fluid after decoction
Point；General flavone, stevioside isoreactivity ingredient in snow chrysanthemum and STEVIA REBAUDIANA are extracted using the method for low-concentration ethanol reflux, water decocts
Method extract vine tea, dihydromyricetin, general flavone, Total saponin and amino acid etc. in Ilex Latifolia Thunb, not only obtain active constituent
The method for having arrived sufficient extraction, and separately having extracted can also reduce influencing each other between each ingredient, obtain effective component purity
To raising, the introducing and content of impurity are reduced；Using the method dried extract lotion of spray drying, low energy consumption, pollution is small,
Moisture evaporation is rapid, drying time is short, saves the techniques such as devaporation, crushing, and quality of item is good, stability is strong, dissolubility is high.
2, the preparation of tea bag:
Snow chrysanthemum, STEVIA REBAUDIANA are first dried in vacuo by the present invention under cryogenic, effectively kept pharmaceutical activity at
The former fragrance and mouthfeel of the effect of dividing and chrysanthemum；Part Ilex Latifolia Thunb uses the original powder of frying, has both remained the faint scent of tea and sweet
Alcohol, and acquisition extract is extracted since remainder and vine tea are total to water, so that active constituent is fully used, also improves bag
The dissolution made tea.The tea bag made in this way color, in terms of all achieve extraordinary effect.
Test the safety testing of 3, product of the present invention
Sample A1-A9 made from 1-9 of the embodiment of the present invention is taken, according to 10 times of people's dosage, 20 times, 50 times of dosage, use is small
Mouse carries out toxicological experiment research, and results of animal shows, at 10 times, 20 times of people's dosage mouse weight without significant change, without essence
Mind is depressed, movable reduction or other symptoms occur, and there are slight apathetic phenomenon in 50 times of people's dosage whens.Prove product of the present invention poison
Small side effects are very beneficial for clinical use.
Experiment 4, the stability test of product of the present invention
Sample A1-A9 made from 1-9 of the embodiment of the present invention is taken, at 40 DEG C ± 2 DEG C of temperature, relative humidity 75% ± 5%
Under the conditions of carry out accelerated stability test, respectively 1st month during test, 2 months, 3 months, the sampling of 6 the end of month once into
Row is investigated；Using character, moisture, effective active composition content and health examination as index, the stability of product is checked.As a result
Show: products of the present invention is stored under the conditions of accelerated test, and each investigation project is showed no exception, and moisture variation control exists
Within 5%, significant change does not also occur for active constituent content, and health examination meets expected regulation, shows production of the present invention
Quality meets the requirements.
From the above data, the present invention can have using product made of the ingredients such as snow chrysanthemum, STEVIA REBAUDIANA, vine tea, Ilex Latifolia Thunb
Effect prevents " three high " disease, investigates by curative effect, safety, product quality etc., and corresponding index is properly arrived at expection and wants
It asks, illustrates inventive formulation design rationally, preparation method is simply controllable, has a good application prospect.
Specific embodiment
Be explained further the present invention below with reference to embodiment and test example, but the content of present invention be not limited to it is as described below.
Embodiment
Embodiment 1: tablet and preparation
Formula: snow chrysanthemum 2.5kg, Ilex Latifolia Thunb 2.0kg, 1.5kg parts of vine tea, STEVIA REBAUDIANA 1kg
Preparation method: 1) crushing snow chrysanthemum, spare with extraction by steam distillation volatile oil；The dregs of a decoction and stevioside leaf are measured with 8 times
Concentration be 30% alcohol reflux extract 2 times, 1 hour every time, extracting solution filtering, filtrate merge, concentration be formed in 55-60 DEG C
The medicinal extract that lower relative density is 1.20；
2) vine tea, Ilex Latifolia Thunb are taken, with 8 times of water boiling and extraction 3 times measured, 2 hours every time, extracting solution filtering, filtrate merged,
Concentration is formed in the medicinal extract that relative density is 1.20 at 55-60 DEG C；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried,
The microcrystalline cellulose of tablet total amount 15% is added in medicinal powder after drying, remaining is supplemented to full dose with pregelatinized starch, is added
The snow chrysanthemum volatile oil of collection, is mixed evenly, and is pelletized with 8% starch slurry, dry, and the magnesium stearate of tablet total amount 1%, pressure is added
Piece is to get 1000, tablet.Every slice weight 0.5g.
Usage and dosage: one time 2,2-3 times on the one.
Embodiment 2: tablet and preparation
Formula: snow chrysanthemum 2.0kg, Ilex Latifolia Thunb 2.5kg, vine tea 0.5kg, STEVIA REBAUDIANA 0.5kg
Preparation method: 1) crushing snow chrysanthemum, spare with extraction by steam distillation volatile oil；The dregs of a decoction and stevioside leaf are measured with 8 times
Concentration be 40% alcohol reflux extract 2 times, 1 hour every time, extracting solution filtering, filtrate merge, concentration be formed at 60 DEG C
The medicinal extract that relative density is 1.15；
2) vine tea, Ilex Latifolia Thunb are taken, with 8 times of water boiling and extraction 3 times measured, 2 hours every time, extracting solution filtering, filtrate merged,
Concentration is formed in the medicinal extract that relative density is 1.10 at 60 DEG C；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried,
The microcrystalline cellulose of tablet total amount 20% is added in medicinal powder after drying, remaining is supplemented to full dose with pregelatinized starch, is added
The snow chrysanthemum volatile oil of collection, is mixed evenly, and is pelletized with 8% starch slurry, dry, and the magnesium stearate of tablet total amount 0.5%, pressure is added
Piece is to get 1000, tablet.
Embodiment 3: capsule and preparation
Formula: snow chrysanthemum 0.8kg, Ilex Latifolia Thunb 0.8kg, vine tea 0.5kg, STEVIA REBAUDIANA 0.2kg
Preparation method: 1) crushing snow chrysanthemum, spare with extraction by steam distillation volatile oil；The dregs of a decoction and stevioside leaf are measured with 10 times
Concentration be 20% alcohol reflux extract 3 times, 0.5 hour every time, extracting solution filtering, filtrate merge, concentration be formed in 55 DEG C
The medicinal extract that lower relative density is 1.30；
2) vine tea, Ilex Latifolia Thunb are taken, with 10 times of water boiling and extraction 2 times measured, 3 hours every time, extracting solution filtering, filtrate was closed
And the medicinal extract for being formed in that relative density is 1.30 at 55 DEG C is concentrated；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried,
The microcrystalline cellulose of capsule total amount 12% is added in medicinal powder after drying, remaining is supplemented to full dose with cornstarch, is added
The snow chrysanthemum volatile oil of collection, is mixed evenly, and pelletizes, dry, and the magnesium stearate of total amount 0.5-1% is added, encapsulated after mixing, i.e.,
Obtain capsule 1000.Every dress 0.3g.
Usage and dosage: once two grains, 2-3 times on the one.
Embodiment 4: granule and preparation
Formula: snow chrysanthemum 6kg, Ilex Latifolia Thunb 6kg, vine tea 4kg, STEVIA REBAUDIANA 2kg
Preparation method: 1) crushing snow chrysanthemum, spare with extraction by steam distillation volatile oil；The dregs of a decoction and stevioside leaf are measured with 6 times
Concentration be 50% alcohol reflux extract 1.5 hours, extracting solution filtering, it is 1.25 that concentration, which is formed in relative density at 60 DEG C,
Medicinal extract；
2) vine tea, Ilex Latifolia Thunb are taken, with 6 times of water boiling and extraction 4 times measured, 1 hour every time, extracting solution filtering, filtrate merged,
Concentration is formed in the medicinal extract that relative density is 1.20 at 60 DEG C；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried,
Snow chrysanthemum volatile oil, the dextrin collected are added in medicinal powder after drying and is supplemented to full dose, mixes, pelletizes, dry, whole grain, packaging,
Up to 1000 bags of granule.Per packed 5g.
Usage and dosage: once a bag, 2-3 times on the one.
Embodiment 5: oral solution and preparation
Formula: snow chrysanthemum 1.5kg, Ilex Latifolia Thunb 1.5kg, vine tea 1kg, STEVIA REBAUDIANA 0.5kg
Preparation method: 1) crushing snow chrysanthemum, spare with extraction by steam distillation volatile oil；The dregs of a decoction and stevioside leaf are measured with 9 times
Concentration be 25% alcohol reflux extract 2 times, 1.5 hours every time, extracting solution filtering, filtrate merge, concentration be formed in 60 DEG C
The medicinal extract that lower relative density is 1.15；
2) vine tea, Ilex Latifolia Thunb are taken, with 9 times of water boiling and extraction 4 times measured, 1 hour every time, extracting solution filtering, filtrate merged,
Concentration is formed in the medicinal extract that relative density is 1.25 at 60 DEG C；
3) by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, total amount is added water to
50%, the snow chrysanthemum volatile oil of collection is added, mixes, simple syrup adds to sugar content 15%, and 0.1% sodium benzoate is added, adds distillation
Water mixes, filtering, encapsulating is to get oral solution 1000 to full dose.Every dress 10ml.
Usage and dosage: a 10ml, 2-3 times on the one.
Embodiment 6: tea beverage and preparation
Formula: snow chrysanthemum 4kg, Ilex Latifolia Thunb 1.5kg, vine tea 1kg, STEVIA REBAUDIANA 0.5kg
Preparation method: 1) crushing snow chrysanthemum, stevioside leaf, the alcohol reflux extraction that the concentration measured with 6 times is 40% 3 times, every time
0.5 hour, extracting solution filtering, filtrate merged, spare；
2) vine tea, Ilex Latifolia Thunb are taken, with 10 times of water boiling and extraction 2 times measured, 2 hours every time, extracting solution filtering, filtrate was closed
And it is spare；
3) by extract solution made from step 1 and 2, add the chitosan of crude drug amount 1%, stand 24 hours, filtration, filtrate
Add water, stir evenly, adjusts pH value to 4-5, the rock sugar of beverage total amount 6%, 0.05% citric acid, sterile filtration, filtrate point is added
Dress, rolls lid, 1000 box of beverage is made.Every box fills 150ml.
Usage and dosage: one time 1 bottle, 2-3 times on the one.
Embodiment 7: tea beverage and preparation
Formula: snow chrysanthemum 3kg, Ilex Latifolia Thunb 3kg, vine tea 2kg, STEVIA REBAUDIANA 1kg
Preparation method: 1) crushing snow chrysanthemum, stevioside leaf, and the alcohol reflux that the concentration measured with 10 times is 30% extracts 1.5 hours,
Extracting solution filtering, it is spare；
2) vine tea, Ilex Latifolia Thunb are taken, with 6 times of water boiling and extraction 4 times measured, 1 hour every time, extracting solution filtering, filtrate merged,
It is spare；
3) by extract solution made from step 1 and 2, add the chitosan of crude drug amount 1%, stand 24 hours, filtration, filtrate
Add water, stir evenly, adjusts pH value to 4-5, the rock sugar of beverage total amount 9%, 0.12% citric acid, sterile filtration, filtrate point is added
Dress, rolls lid, 1000 box of beverage is made.Every box fills 150ml.
Embodiment 8: tea bag and preparation
Formula: snow chrysanthemum 6kg, Ilex Latifolia Thunb 3kg, vine tea 4kg, STEVIA REBAUDIANA 2kg
Preparation method: 1) taking snow chrysanthemum, the STEVIA REBAUDIANA of formula ratio, and water content is dried under vacuum at 0 DEG C less than 5%, is ground into fine powder,
It is spare to cross 60 meshes；
2) lectuce tea powder of formula ratio 50% is taken to be broken into the coarse powder that granularity is 0.2-0.3mm, remaining Ilex Latifolia Thunb and formula ratio
Vine tea branches and leaves, add 6 times of amounts, concentration be 85% ethanol solution refluxing extraction 2 times, 1 hour every time, combined extract, filtering, it is dense
Contracting is formed in the medicinal extract that relative density at 55-60 DEG C is 1.20-1.30；
3) frying pot is opened, adjusting temperature is 75 DEG C, and stirring rod speed is 80 revs/min, is put into Ilex Latifolia Thunb coarse powder stir-frying 10
After minute, extract medicinal extract made from the snow chrysanthemum powder and sweetleaf inulin and step 2) of addition step 1) after being sufficiently mixed, will be mixed
It closes object to be put into sterilizing, drying equipment, first high-temperature sterilization, is then cooled to 80 DEG C rapidly hereinafter, low temperature drying, it is whole to cross 80 meshes
Grain, be distributed into 1000 bags to get.
Usage and dosage: 1 bag every time, 2-3 times on the one.
Embodiment 9: tea bag and preparation
Formula: snow chrysanthemum 3kg, Ilex Latifolia Thunb 2kg, vine tea 0.5kg, STEVIA REBAUDIANA 0.5kg
Preparation method: 1) taking snow chrysanthemum, the STEVIA REBAUDIANA of formula ratio, and water content is dried under vacuum at 6 DEG C less than 5%, is ground into fine powder,
It is spare to cross 60 meshes；
2) lectuce tea powder of formula ratio 70% is taken to be broken into the coarse powder that granularity is 0.2-0.3mm, remaining Ilex Latifolia Thunb and formula ratio
Vine tea branches and leaves, adding 10 times of amounts, concentration is 55% ethanol solution refluxing extraction 2 hours, and combined extract, filtering, concentration is made
Relative density is the medicinal extract of 1.20-1.30 at 55-60 DEG C；
3) frying pot is opened, adjusting temperature is 85 DEG C, and stirring rod speed is 120 revs/min, is put into Ilex Latifolia Thunb coarse powder stir-frying 20
After minute, extract medicinal extract made from the snow chrysanthemum powder and sweetleaf inulin and step 2) of addition step 1) after being sufficiently mixed, will be mixed
It closes object to be put into sterilizing, drying equipment, first high-temperature sterilization, is then cooled to 80 DEG C rapidly hereinafter, low temperature drying, it is whole to cross 80 meshes
Grain, be distributed into 1000 bags to get.
Embodiment 10: high formula ratio tablet
Formula: snow chrysanthemum 7kg, Ilex Latifolia Thunb 7kg, vine tea 5kg, STEVIA REBAUDIANA 3kg
Preparation method: with embodiment 1.
Embodiment 11: low formula ratio tablet
Formula: snow chrysanthemum 0.5kg, Ilex Latifolia Thunb 0.5kg, vine tea 0.3kg, STEVIA REBAUDIANA 0.1kg
Preparation method: with embodiment 1.
Claims (11)
1. a kind of compound snow chrysanthemum product, which is characterized in that the product is made of raw material from the following weight: 0.8-6 parts of snow chrysanthemum,
0.8-6 parts of Ilex Latifolia Thunb, 0.5-4 parts of vine tea, 0.2-2 parts of STEVIA REBAUDIANA,
The product be drug, health care product or food,
The preparation method of the compound snow chrysanthemum drug or health care product the following steps are included:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；The concentration that the dregs of a decoction and stevioside leaf are measured with 6-10 times
It is extracted 1-3 times for the alcohol reflux of 65%-100%, 0.5-1.5 hours each, extracting solution filtering, filtrate merges, and concentration is made
Relative density is the medicinal extract of 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filtrate close
And it is concentrated and is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried or is directly added into
The snow chrysanthemum volatile oil of extraction adds pharmaceutic adjuvant, required tablet, capsule, granule, oral solution is made.
2. compound snow chrysanthemum product as described in claim 1, which is characterized in that the parts by weight of raw materials of the product are as follows: snow chrysanthemum
1.5-3 parts, 1.5-3 parts of Ilex Latifolia Thunb, 1-2 parts of vine tea, 0.5-1 parts of STEVIA REBAUDIANA.
3. compound snow chrysanthemum product as described in claim 1, which is characterized in that the dosage form of the drug or health care product be tablet,
Capsule, granule or oral solution.
4. compound snow chrysanthemum product as described in claim 1, which is characterized in that the type of the food is tea beverage, tea bag.
5. compound snow chrysanthemum product as described in claim 1, which is characterized in that the compound snow chrysanthemum tablet the preparation method comprises the following steps:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；The concentration that the dregs of a decoction and stevioside leaf are measured with 6-10 times
It is extracted 1-3 times for the alcohol reflux of 20%-50%, 0.5-1.5 hours each, extracting solution filtering, filtrate merges, and concentration is formed in
Relative density is the medicinal extract of 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filtrate close
And it is concentrated and is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried, in drying
The microcrystalline cellulose of tablet total amount 15-20% is added in medicinal powder afterwards, remaining is supplemented to full dose with pregelatinized starch, and addition has been received
The snow chrysanthemum volatile oil of collection, is mixed evenly, and is pelletized with 8% starch slurry, dry, and the magnesium stearate of tablet total amount 0.5-1%, pressure is added
Piece to get.
6. compound snow chrysanthemum product as described in claim 1, which is characterized in that the preparation method of the compound snow chrysanthemum capsule
Are as follows:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；The concentration that the dregs of a decoction and stevioside leaf are measured with 6-10 times
It is extracted 1-3 times for the alcohol reflux of 20%-50%, 0.5-1.5 hours each, extracting solution filtering, filtrate merges, and concentration is formed in
Relative density is the medicinal extract of 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filtrate close
And it is concentrated and is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried, in drying
The microcrystalline cellulose of capsule total amount 12-15% is added in medicinal powder afterwards, remaining is supplemented to full dose with cornstarch, and addition has been received
The snow chrysanthemum volatile oil of collection, is mixed evenly, and pelletizes, dry, and the magnesium stearate of total amount 0.5-1% is added, encapsulated after mixing, i.e.,
?.
7. compound snow chrysanthemum product as described in claim 1, which is characterized in that the preparation method of the compound snow chrysanthemum granule
Are as follows:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；The concentration that the dregs of a decoction and stevioside leaf are measured with 6-10 times
It is extracted 1-3 times for the alcohol reflux of 20%-50%, 0.5-1.5 hours each, extracting solution filtering, filtrate merges, and concentration is formed in
Relative density is the medicinal extract of 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filtrate close
And it is concentrated and is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) it by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, is spray-dried, in drying
Snow chrysanthemum volatile oil, the dextrin collected are added in medicinal powder afterwards, mixes, pelletizes, dry, whole grain is packed to get granule.
8. compound snow chrysanthemum product as described in claim 1, which is characterized in that the preparation method of the compound snow chrysanthemum oral solution
Are as follows:
1) snow chrysanthemum is crushed, it is spare with extraction by steam distillation volatile oil；The concentration that the dregs of a decoction and stevioside leaf are measured with 6-10 times
It is extracted 1-3 times for the alcohol reflux of 20%-50%, 0.5-1.5 hours each, extracting solution filtering, filtrate merges, and concentration is formed in
Relative density is the medicinal extract of 1.15-1.30 at 55-60 DEG C；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filtrate close
And it is concentrated and is formed in the medicinal extract that relative density at 55-60 DEG C is 1.10-1.30；
3) by the extract medicinal extract of aforementioned snow chrysanthemum obtained, STEVIA REBAUDIANA, vine tea and Ilex Latifolia Thunb, the 50% of total amount is added water to, is added
Enter the snow chrysanthemum volatile oil of collection, mix, simple syrup adds to sugar content 15-20%, and 0.1% sodium benzoate is added, adds distilled water extremely
Full dose mixes, and filtering, encapsulating is to get oral solution.
9. compound snow chrysanthemum product as claimed in claim 4, which is characterized in that the preparation method packet of the compound snow chrysanthemum tea beverage
Containing following steps:
1) snow chrysanthemum, stevioside leaf are crushed, the alcohol reflux extraction that the concentration measured with 6-10 times is 20%-50% 1-3 times, every time
0.5-1.5 hours, extracting solution filtering, filtrate merged, spare；
2) vine tea, Ilex Latifolia Thunb are taken, with 6-10 times the water boiling and extraction measured 2-4 times, it is 1-3 hours each, extracting solution filtering, filtrate close
And it is spare；
3) by extract solution made from step 1 and 2, add the chitosan of crude drug amount 1%, stand 24 hours, filtration, filtrate adds
Water stirs evenly, and adjusts pH value to 4-5, the rock sugar of beverage total amount 6-9%, the citric acid of 0.05-0.12%, sterile filtration, filter is added
Liquid packing, rolls lid, beverage is made.
10. compound snow chrysanthemum product as claimed in claim 4, which is characterized in that the preparation method of the compound snow chrysanthemum tea bag
It comprises the steps of:
1) snow chrysanthemum, the STEVIA REBAUDIANA of formula ratio are taken, water content is dried under vacuum at 0-6 DEG C less than 5%, is ground into fine powder, crosses 60 mesh
It sieves spare；
2) lectuce tea powder of formula ratio 50%-70% is taken to be broken into the coarse powder that granularity is 0.2-0.3mm, remaining Ilex Latifolia Thunb and formula ratio
Vine tea branches and leaves, add 6-10 times of amount, concentration be 55%-75% ethanol solution refluxing extraction 1-2 times, 1-2 hours each, merging mentions
Liquid is taken, is filtered, concentration is formed in the medicinal extract that relative density at 55-60 DEG C is 1.20-1.30；
3) frying pot is opened, adjusting temperature is 75-85 DEG C, and stirring rod speed is 80-120 revs/min, is put into the stir-frying of Ilex Latifolia Thunb coarse powder
After 10-20 minutes, extract medicinal extract made from the snow chrysanthemum powder and sweetleaf inulin and step 2) of addition step 1), after being sufficiently mixed,
Mixture is put into sterilizing, drying equipment, first high-temperature sterilization, is then cooled to 80 DEG C rapidly hereinafter, low temperature drying, crosses 80 mesh
Sieve whole grain, packing to get.
11. the described in any item compound snow chrysanthemum products of claim 1-10 have blood pressure lowering, hypoglycemic and reducing blood lipid three in preparation
Application in functional product is dropped.
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| CN105901230A (en) * | 2016-04-27 | 2016-08-31 | 济南舒美生物科技有限公司 | Compound health tea with efficacy of hyperuricemia inhibition |
| CN106173060A (en) * | 2016-07-12 | 2016-12-07 | 董雪 | A kind of Folium Chrysanthemi health tea and preparation method thereof |
| CN106690317A (en) * | 2016-11-11 | 2017-05-24 | 贵州黔贵天赐大健康集团有限公司 | Radix salviae miltiorrhizae composition and preparation method thereof |
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| CN103493940A (en) * | 2013-10-16 | 2014-01-08 | 四川好医生攀西药业有限责任公司 | Sanvitalia and tartary buckwheat composition and method for manufacturing same |
| CN103891961A (en) * | 2014-04-14 | 2014-07-02 | 张掖市亚兰生物科技有限公司 | Plains coreopsis and schizonepeta tea |
| CN103891960A (en) * | 2014-04-14 | 2014-07-02 | 张掖市亚兰生物科技有限公司 | Tea made of plain coreopsis and red dates |
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| CN103493940A (en) * | 2013-10-16 | 2014-01-08 | 四川好医生攀西药业有限责任公司 | Sanvitalia and tartary buckwheat composition and method for manufacturing same |
| CN103891961A (en) * | 2014-04-14 | 2014-07-02 | 张掖市亚兰生物科技有限公司 | Plains coreopsis and schizonepeta tea |
| CN103891960A (en) * | 2014-04-14 | 2014-07-02 | 张掖市亚兰生物科技有限公司 | Tea made of plain coreopsis and red dates |
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