CN106509894A - Moringa oleifera and pseudo-ginseng buccal tablets and preparation technology thereof - Google Patents
Moringa oleifera and pseudo-ginseng buccal tablets and preparation technology thereof Download PDFInfo
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- CN106509894A CN106509894A CN201610977410.0A CN201610977410A CN106509894A CN 106509894 A CN106509894 A CN 106509894A CN 201610977410 A CN201610977410 A CN 201610977410A CN 106509894 A CN106509894 A CN 106509894A
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- CN
- China
- Prior art keywords
- moringa
- parts
- buccal tablets
- sanchi
- pseudo
- Prior art date
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Landscapes
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to moringa oleifera and pseudo-ginseng buccal tablets and a preparation method thereof, and belongs to the technical field of processing of buccal tablets. The moringa oleifera and pseudo-ginseng buccal tablets are prepared from main components of moringa oleifera leaves, pseudo-ginseng, sanchi flowers, Chinese yams, radix puerariae, vanillin, dextrin, xylitol, steviol glycoside, mannitol, menthol, 8% HPMC, 4% polyacrylic resin and magnesium stearate. The preparation method comprises the specific steps of cutting up the pseudo-ginseng, the sanchi flowers, the Chinese yams and the radix puerariae, and performing decoction with pure water so as to obtain extractum; uniformly mixing moringa oleifera leaf powder with the vanillin, the dextrin, the xylitol, the steviol glycoside, the mannitol and the extractum, then adding the 8% HPMC and the 4% polyacrylic resin, and performing uniform mixing; performing granulation, performing loading into plates, and then performing baking; spray-coating a menthol ethanol solution on baked granules, and then performing drying; and finally adding magnesium stearate, performing screening, performing granule trimming and separating, performing tabletting, and performing packaging. According to the moringa oleifera and pseudo-ginseng buccal tablets and the preparation method thereof disclosed by the invention, the moringa oleifera, the pseudo-ginseng, the radix puerariae and the Chinese yams are used as main materials, so that the obtained products can reduce blood pressure, reduce blood sugar, replenish blood, promote blood circulation, complement trace elements and enhance organism immunity, and the prepared buccal tablets are regular in tablet types and cannot be loose.
Description
Technical field
The invention belongs to buccal tablet processing technique field, specifically, is related to a kind of Moringa Sanchi buccal tablets and preparation method thereof.
Background technology
Moringa, is also called drumstick tree, is perennial tropical deciduous tree.The Moringa age of tree about up to 20 years, the height of tree up to 7～
12 meters, up to 20～40 centimeters, bark is soft wood to trunk diameter, and root has acid, and flower is symmetrical for conical inflorescence
Axil is given birth to, and is hermaphrodite flower, savory, and petal has five, white or milk yellow, fragrant odour.
Moringa is most nutritious tree in the world, and it includes about 20 kinds of aminoacid, 46 kinds of antioxidants, anti-inflammatory compound,
Rich in abundant trace elements K, manganese, chromium, and arginine, lysine, leucine, Phenylalanine etc., there is provided vitamin A, dimension
Raw element B, B1, B2, B3, B6, vitamin C (ascorbic acid), Vitamin E and macroscopical mineral, trace element, there is provided high-quality protein
Matter and dietary fiber, calcareous contained by leaf of Moringa is 4 times of milk, and protein is 2 times of milk, and potassium is 3 times of Fructus Musae, and ferrum is
3 times of Herba Spinaciae, vitamin C are 7 times of Citrus, and vitamin A (bata-carotene) is 4 times of Radix Dauci Sativae, and Vitamin E is spiral respectively
Algae and 70 times and 40 times of analysis for soybean powder.
Radix Notoginseng has the titles such as Radix Notoginseng, blood mountain grass, pouring in June again, and medicine scholar's Li Shizhen (1518-1593 A.D.) famous when being the Ming Dynasty of China claims it
For " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ".Radix Notoginseng is a jewel in Chinese crude drug industry, and it mainly originates in the ground such as Yunnan, Jiangxi, Guangxi, Sichuan ground
Area.Radix Notoginseng has a beauty treatment and eliminating spot, menstruation-regulating face-beautifying, fat-reducing, promoting blood circulation and hemostasis, dissipating blood stasis, detumescence, and effect is attacked in analgesic therapy.Can blood pressure lowering, blood
Fat, anti-cancer, anticancer improve myocardial oxygen delivery ability, strengthen body immune function.
Existing Moringa product is a feast for the eyes, but how will be Radix Notoginseng and Moringa combination and exploitation one kind nutritious, and function is complete
The health promoting product in face is most important.
The content of the invention
In order to overcome the problem in background technology, the present invention to propose a kind of Moringa Sanchi buccal tablets and its preparation technology, energy
Blood pressure lowering, blood sugar lowering, replenishing and activating blood, trace element supplement improve immunity of organisms, are that a nutrition is balanced, health care compared with
Good product.
To realize object above, the present invention is implemented according to technical scheme below：
A kind of Moringa Sanchi buccal tablets, the Moringa Sanchi buccal tablets include following component：Leaf of Moringa, Radix Notoginseng, flower of Radix Notoginseng, mountain
It is medicine, Radix Puerariae, vanillin, dextrin, xylitol, stevioside, Mannitol, Mentholum, 8%HPMC, 4% polyacrylic resin, hard
Fatty acid magnesium.
Further, each weight ratio of constituents part of the Moringa Sanchi buccal tablets is：100～120 parts of leaf of Moringa, Radix Notoginseng 20～30
Part, 40～50 parts of flower of Radix Notoginseng, 15～20 parts of Rhizoma Dioscoreae, 15～20 parts of Radix Puerariae, 3～6 parts of vanillin, 80～100 parts of dextrin, xylitol
20～25 parts, 3～6 parts of stevioside, 3～4 parts of Mannitol, 2～3 parts of Mentholum, 8%HPMC40～45 part, 4% polyacrylic acid
30～50 parts of resin, 1～1.5 part of magnesium stearate.
A kind of preparation technology of Moringa Sanchi buccal tablets, concretely comprises the following steps：
1) will be standby after leaf of Moringa micronizing, Radix Notoginseng, flower of Radix Notoginseng, Rhizoma Dioscoreae, Radix Puerariae are shredded respectively, pure water is decocted and is made
Extractum, Mentholum is dissolved in standby in dehydrated alcohol；
2) by leaf of Moringa powder, vanillin, dextrin, xylitol, stevioside, Mannitol be placed in sterilization after container in step
It is rapid 1) obtained by extractum mix homogeneously, add 8%HPMC, the 4% polyacrylic resin mix homogeneously of formula ratio；
3) mixed material is crossed into the granulation sabot of 20 mesh sieves, is placed in baking in baking oven；
4) even application Mentholum ethanol solution on granule after baking, then enter oven drying, repetitive operation is twice；
5) by magnesium stearate add step 4) obtained by granule in, mix homogeneously, cross 20 mesh sieves carry out granulate；
6) tabletting is carried out after granulate, then removes unnecessary powder and impurity；
7) several pieces packagings, are placed at aeration-drying and deposit.
Preferably, step 3) in, sabot THICKNESS CONTROL is 2～3.
Preferably, step 3) in, oven temperature is controlled at 35 DEG C～40 DEG C, and moisture is dried to 7%～8%.
Preferably, step 6) in, tablet weight is controlled for 0.34～0.36g.
Radix Notoginseng, disappears with hemostasis, blood circulation promoting and blood stasis dispelling rich in effective ingredient such as arasaponin, Radix Notoginseng polysaccharide, dencichine, flavone
The effects such as swollen analgesic therapy, strengthening by means of tonics, resisting fatigue, anoxia enduring, defying age, blood fat reducing, blood sugar lowering, raising body's immunity.Can
For treating the various inside and outside hemorrhages such as traumatic hemorrhage, blood stasis, gastrorrhagia, hematuria；Expansion of blood vessels, thrombus improve micro- following
The cardiovascular and cerebrovascular diseases such as ring, prevention and treatment hyperlipidemia, cholesterol increase, coronary heart diseases and angina pectoris, apoplexy sequela.
Rhizoma Dioscoreae is conducive to taste digestive and absorptive functions, is the product of the medicine-food two-purpose of flat tonifying the spleen and stomach simply；With strong body,
The effect of kidney nourishing and replenishing vital essence；There is the hypoglycemic effect of drop, can be used to treat diabetes, be the diet good food of diabetes patient；Can be effective
Prevent blood fat in the precipitation of blood vessel wall, prevent cardiovascular diseases.Obtain the mind calming and mentality promoting, effect of life lengthening.
Radix Puerariae it there is heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, kidney and spleen invigorating, stomach reinforcing to calm the nerves, the improving eyesight that clears away heart-fire, intestine moistening road just and relieving alcoholic intoxication
Etc. function.Its starch includes the flavone compound active ingredient such as puerarin, records according to medical science, and its starch is to relieving the exterior syndrome by diaphoresis, liter
Sun dissipate fire, master quench one's thirst burning hot, headache fever, bone fire, person's back inflexible pain, relieving alcoholic intoxication, relieving restlessness, especially to diabetes, cardiovascular diseasess, the intestines and stomach
The Diseases such as digestive system will be the unique health food that can not look for more optimal body-building face-nourishing.
Beneficial effects of the present invention：The present invention adopts leaf of Moringa, Radix Notoginseng, Radix Puerariae, Rhizoma Dioscoreae for major ingredient, and blood can drop in products obtained therefrom
Pressure, blood sugar lowering, replenishing and activating blood, trace element supplement improve immunity of organisms, using specific preparation technology, obtained buccal tablet
Piece type it is regular, will not be loose.
Specific embodiment
A kind of Moringa Sanchi buccal tablets, the Moringa Sanchi buccal tablets include following component：Leaf of Moringa, Radix Notoginseng, flower of Radix Notoginseng, mountain
It is medicine, Radix Puerariae, vanillin, dextrin, xylitol, stevioside, Mannitol, Mentholum, 8%HPMC, 4% polyacrylic resin, hard
Fatty acid magnesium.
The each weight ratio of constituents part of the Moringa Sanchi buccal tablets is：100～120 parts of leaf of Moringa, 20～30 parts of Radix Notoginseng, flower of Radix Notoginseng
40～50 parts, 15～20 parts of Rhizoma Dioscoreae, 15～20 parts of Radix Puerariae, 3～6 parts of vanillin, 80～100 parts of dextrin, 20～25 parts of xylitol,
3～6 parts of stevioside, 3～4 parts of Mannitol, 2～3 parts of Mentholum, 8%HPMC40～45 part, 4% polyacrylic resin 30～
50 parts, 1～1.5 part of magnesium stearate.
A kind of preparation technology of Moringa Sanchi buccal tablets, concretely comprises the following steps：
It is that powder is standby by leaf of Moringa micronizing；Mentholum is dissolved in standby in dehydrated alcohol, solid-liquid ratio 1:3；
Radix Notoginseng, flower of Radix Notoginseng, Rhizoma Dioscoreae, Radix Puerariae are shredded respectively, four are siccative, and first Radix Notoginseng is added water to cook with flower of Radix Notoginseng
30～40min, solid-liquid ratio are 1:9, Radix Puerariae is subsequently adding, then after decocting 90～120min, adds Rhizoma Dioscoreae, stop decocting, in ultrasound
Under the conditions of extract 40～50min, 800～1200W of ultrasonic power, maintain liquid temperature at 80～100 DEG C, filtering sedimentation, to take supernatant dense
Paste is reduced to, extractum is obtained；
By leaf of Moringa powder, vanillin, dextrin, xylitol, stevioside, Mannitol be placed in sterilization after container in and extractum
Mix homogeneously, adds 8%HPMC, the 4% polyacrylic resin mix homogeneously of formula ratio；
Mixed material is crossed into the granulation sabot of 20 mesh sieves, baking in baking oven is placed in, oven temperature control 35 DEG C～
40 DEG C, moisture is dried to 7%～8%；Even application Mentholum ethanol solution on granule after baking, then enter oven drying,
Oven temperature is 35 DEG C～40 DEG C, is toasted 10～12 minutes, and repetitive operation is twice；
Magnesium stearate is added in the granule obtained by above-mentioned steps, mix homogeneously, crossing 20 mesh sieves carries out granulate；
Tabletting is carried out after granulate, then removes unnecessary powder and impurity；
Finally, several pieces packagings, are placed at aeration-drying and deposit.
Embodiment 1
A kind of Moringa Sanchi buccal tablets, each weight ratio of constituents part of the Moringa Sanchi buccal tablets is：100 parts of leaf of Moringa, Radix Notoginseng 30
It is part, 50 parts of flower of Radix Notoginseng, 15 parts of Rhizoma Dioscoreae, 15 parts of Radix Puerariae, 5 parts of vanillin, 80 parts of dextrin, 20 parts of xylitol, 4 parts of stevioside, sweet
3 parts of alcohol of dew, 3 parts of Mentholum, 8%HPMC42 parts, 40 parts of 4% polyacrylic resin, 1 part of magnesium stearate.
Its preparation technology is：
Will be standby after leaf of Moringa micronizing；Mentholum is dissolved in standby in dehydrated alcohol, solid-liquid ratio 1:3；
Radix Notoginseng, flower of Radix Notoginseng, Rhizoma Dioscoreae, Radix Puerariae are shredded respectively, Radix Notoginseng powder adds water to cook 30min, solid-liquid ratio with notogenseng pollen
For 1:9, powder of Radix Puerariae is subsequently adding, then after decocting 100min, adds Rhizoma Dioscoreae, stop decocting, 50min is extracted under ultrasound condition, surpass
Acoustical power 800W, maintains liquid temperature at 80 DEG C, filters sedimentation and takes supernatant concentration to paste, obtains extractum；
By leaf of Moringa powder, vanillin, dextrin, xylitol, stevioside, Mannitol be placed in sterilization after container in and extractum
Mix homogeneously, adds 8%HPMC, the 4% polyacrylic resin mix homogeneously of formula ratio；
Mixed material is crossed into the granulation sabot of 20 mesh sieves, sabot THICKNESS CONTROL is placed in baking, baking oven in baking oven 2
Temperature control at 35 DEG C, dry to 7% by moisture；Even application Mentholum ethanol solution on granule after baking, then enter baking oven
It is dried, oven temperature is 38 DEG C, is toasted 10 minutes, and repetitive operation is twice；
Magnesium stearate is added in the granule obtained by above-mentioned steps, mix homogeneously, crossing 20 mesh sieves carries out granulate；
Tabletting is carried out after granulate, it is 0.34g to control tablet weight, then removes unnecessary powder and impurity；
Finally, several pieces packagings, are placed at aeration-drying and deposit.
Embodiment 2
A kind of Moringa Sanchi buccal tablets, each weight ratio of constituents part of the Moringa Sanchi buccal tablets is：105 parts of leaf of Moringa, Radix Notoginseng 20
It is part, 45 parts of flower of Radix Notoginseng, 18 parts of Rhizoma Dioscoreae, 18 parts of Radix Puerariae, 3 parts of vanillin, 85 parts of dextrin, 25 parts of xylitol, 3 parts of stevioside, sweet
4 parts of alcohol of dew, 2 parts of Mentholum, 40 parts of 8%HPMC, 42 parts of 4% polyacrylic resin, 1.5 parts of magnesium stearate.
Its preparation technology is：
Will be standby after leaf of Moringa micronizing；Mentholum is dissolved in standby in dehydrated alcohol, solid-liquid ratio 1:3；
Radix Notoginseng, flower of Radix Notoginseng, Rhizoma Dioscoreae, Radix Puerariae are shredded respectively, Radix Notoginseng powder adds water to cook 35min, solid-liquid ratio with notogenseng pollen
For 1:9, powder of Radix Puerariae is subsequently adding, then after decocting 90min, adds Rhizoma Dioscoreae, stop decocting, 46min is extracted under ultrasound condition, surpass
Acoustical power 1000W, maintains liquid temperature at 90 DEG C, filters sedimentation and takes supernatant concentration to paste, obtains extractum；
By leaf of Moringa powder, vanillin, dextrin, xylitol, stevioside, Mannitol be placed in sterilization after container in and extractum
Mix homogeneously, adds 8%HPMC, the 4% polyacrylic resin mix homogeneously of formula ratio；
Mixed material is crossed into the granulation sabot of 20 mesh sieves, sabot THICKNESS CONTROL is placed in baking in baking oven, dries 2.5
Case temperature control at 38 DEG C, dry to 7% by moisture；Even application Mentholum ethanol solution on granule after baking, then entering to dry
Case is dried, and oven temperature is 35 DEG C, is toasted 12 minutes, and repetitive operation is twice；
Magnesium stearate is added in the granule obtained by above-mentioned steps, mix homogeneously, crossing 20 mesh sieves carries out granulate；
Tabletting is carried out after granulate, it is 0.35g to control tablet weight, then removes unnecessary powder and impurity；
Finally, several pieces packagings, are placed at aeration-drying and deposit.
Embodiment 3
A kind of Moringa Sanchi buccal tablets, each weight ratio of constituents part of the Moringa Sanchi buccal tablets is：120 parts of leaf of Moringa, Radix Notoginseng 22
It is part, 40 parts of flower of Radix Notoginseng, 20 parts of Rhizoma Dioscoreae, 20 parts of Radix Puerariae, 6 parts of vanillin, 100 parts of dextrin, 22 parts of xylitol, 6 parts of stevioside, sweet
3.2 parts of alcohol of dew, 2.5 parts of Mentholum, 45 parts of 8%HPMC, 50 parts of 4% polyacrylic resin, 1.3 parts of magnesium stearate.
Its preparation technology is：
Will be standby after leaf of Moringa micronizing；Mentholum is dissolved in standby in dehydrated alcohol, solid-liquid ratio 1:3；
Radix Notoginseng, flower of Radix Notoginseng, Rhizoma Dioscoreae, Radix Puerariae are shredded respectively, Radix Notoginseng powder adds water to cook 35min, solid-liquid ratio with notogenseng pollen
For 1:9, powder of Radix Puerariae is subsequently adding, then after decocting 120min, adds Rhizoma Dioscoreae, stop decocting, 40min is extracted under ultrasound condition, surpass
Acoustical power 1200W, maintains liquid temperature at 100 DEG C, filters sedimentation and takes supernatant concentration to paste, obtains extractum；
By leaf of Moringa powder, vanillin, dextrin, xylitol, stevioside, Mannitol be placed in sterilization after container in and extractum
Mix homogeneously, adds 8%HPMC, the 4% polyacrylic resin mix homogeneously of formula ratio；
Mixed material is crossed into the granulation sabot of 20 mesh sieves, sabot THICKNESS CONTROL is placed in baking, baking oven in baking oven 3
Temperature control at 40 DEG C, dry to 7% by moisture；Even application Mentholum ethanol solution on granule after baking, then enter baking oven
It is dried, oven temperature is 40 DEG C, is toasted 10 minutes, and repetitive operation is twice；
Magnesium stearate is added in the granule obtained by above-mentioned steps, mix homogeneously, crossing 20 mesh sieves carries out granulate；
Tabletting is carried out after granulate, it is 0.35g to control tablet weight, then removes unnecessary powder and impurity；
Finally, several pieces packagings, are placed at aeration-drying and deposit.
Experimental analysiss：
In terms of taste flavor, using double-blind method, 200 clients are randomly selected to 2 gained Moringa three of the embodiment of the present invention
The Moringaceae tablet of seven buccal tablets and Application No. 200510029848.8 is compared, and as a result shows, more than 95% client thinks
Gained Moringa Sanchi buccal tablets unique flavor of the invention, more preferably, free from extraneous odour, the stereovision of taste enrich mouthfeel, can make one after buccal
Spiritual happiness.Compare the Moringaceae tablet of Application No. 200510029848.8, in terms of taste flavor, the present invention achieve compared with
Good effect.
Function of blood sugar reduction is tested：
Diabetic mouse model is set up in mice fasting 12 hours, intraperitoneal injection streptozotocin (135mg/kg).And it is same
When observation mouse diet amount, amount of drinking water and urine volume change；From mouse orbit rear vein beard measuring blood sugar of blood extracting after modeling 14 days
Concentration, blood sugar concentration are diabetic mice higher than normal group twice person.
Diabetic mice after modeling is grouped, 10 per group, respectively matched group, 1 test group of embodiment, enforcement
2 test group of example, 3 test group of embodiment.
Administering mode is：Matched group is dissolved in a piece of buccal tablet in 10ml water, is pressed with water gavage, embodiment 1-3 test group
1ml/10g gavages, successive administration 10 days, daily early morning empty body weight, last dose took blood from retroorbital venous clump after 2 hours
Survey blood glucose.
| Blood glucose | Blood glucose difference | |
| Matched group | 15.94±3.81 | 2.07 |
| 1 test group of embodiment | 5.32±1.25 | -5.69 |
| 2 test group of embodiment | 5.03±0.98 | -5.94 |
| 3 test group of embodiment | 5.45±1.03 | -5.35 |
Can be seen that, compared with matched group, the blood glucose difference after the test group use of embodiment 1-3 is larger have from data above
There is obvious function of blood sugar reduction.
The present invention adopts Moringa, Radix Notoginseng, Radix Puerariae, Rhizoma Dioscoreae for major ingredient, reasonable compatibility, products obtained therefrom energy blood pressure lowering, blood sugar lowering,
Replenishing and activating blood, trace element supplement improve immunity of organisms, and using specific preparation technology, the piece type of obtained buccal tablet is regular,
Will not be loose, each raw material is effectively integrated, maximization embodies the function of each raw material.
Finally, above example is only unrestricted to illustrate technical scheme, although passing through above-described embodiment
The present invention is described in detail, it is to be understood by those skilled in the art that can be right in the form and details
Which makes various changes, without departing from claims of the present invention limited range.
Claims (6)
1. a kind of Moringa Sanchi buccal tablets, it is characterised in that：The Moringa Sanchi buccal tablets include following component：Leaf of Moringa, Radix Notoginseng, three
Seven flowers, Rhizoma Dioscoreae, Radix Puerariae, vanillin, dextrin, xylitol, stevioside, Mannitol, Mentholum, 8%HPMC, 4% polyacrylic acid
Resin, magnesium stearate.
2. a kind of Moringa Sanchi buccal tablets according to claim 1, it is characterised in that：The each composition weight of the Moringa Sanchi buccal tablets
Measure and than part be：100 ~ 120 parts of leaf of Moringa, 20 ~ 30 parts of Radix Notoginseng, 40 ~ 50 parts of flower of Radix Notoginseng, 15 ~ 20 parts of Rhizoma Dioscoreae, 15 ~ 20 parts of Radix Puerariae, perfume
3 ~ 6 parts of blue element, 80 ~ 100 parts of dextrin, 20 ~ 25 parts of xylitol, 3 ~ 6 parts of stevioside, 3 ~ 4 parts of Mannitol, 2 ~ 3 parts of Mentholum,
8%HPMC40 ~ 45 part, 30 ~ 50 parts of 4% polyacrylic resin, 1 ~ 1.5 part of magnesium stearate.
3. the preparation technology of a kind of Moringa Sanchi buccal tablets according to claim 1 and 2, it is characterised in that：Concretely comprise the following steps：
1）Will be standby after leaf of Moringa micronizing, Radix Notoginseng, flower of Radix Notoginseng, Rhizoma Dioscoreae, Radix Puerariae are shredded respectively, pure water is decocted and makes leaching
Cream, Mentholum is dissolved in standby in dehydrated alcohol；
2）With step 1 in the container that leaf of Moringa powder, vanillin, dextrin, xylitol, stevioside, Mannitol are placed in after sterilization）
Gained extractum mix homogeneously, adds 8%HPMC, the 4% polyacrylic resin mix homogeneously of formula ratio；
3）Mixed material is crossed into the granulation sabot of 20 mesh sieves, baking in baking oven is placed in；
4）Even application Mentholum ethanol solution on granule after baking, then enter oven drying, repetitive operation is twice；
5）Magnesium stearate is added into step 4）In the granule of gained, mix homogeneously, crossing 20 mesh sieves carries out granulate；
6）Tabletting is carried out after granulate, then removes unnecessary powder and impurity；
7）Several pieces packagings, are placed at aeration-drying and deposit.
4. the preparation technology of a kind of Moringa Sanchi buccal tablets according to claim 3, it is characterised in that：Step 3）In, sabot
THICKNESS CONTROL is 2 ~ 3.
5. the preparation technology of a kind of Moringa Sanchi buccal tablets according to claim 3, it is characterised in that：Step 3）In, baking oven
Temperature control at 35 DEG C ~ 40 DEG C, dry to 7% ~ 8% by moisture.
6. the preparation technology of a kind of Moringa Sanchi buccal tablets according to claim 3, it is characterised in that：Step 6）In, control
Tablet weight is 0.34 ~ 0.36g.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496477A (en) * | 2017-09-07 | 2017-12-22 | 文山华信三七股份有限公司 | A kind of sugar-free sanchi flower buccal tablet and its production technology |
| CN107772457A (en) * | 2017-09-28 | 2018-03-09 | 广西宜州市宜源桑杆菌业有限公司 | A kind of preparation method of Moringaceae tablet |
| CN108992584A (en) * | 2018-08-28 | 2018-12-14 | 云南奇妙七生物科技有限公司 | A kind of sanchi flower dendrobium nobile lozenge and its preparation process |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742743A (en) * | 2005-09-21 | 2006-03-08 | 重庆康刻尔制药有限公司 | Pseudo-ginseng saponin oral disintegration tablet and preparing method |
| CN101190263A (en) * | 2006-11-30 | 2008-06-04 | 四川宇妥藏药药业有限责任公司 | Rhubarb chewable tablets and preparation method and application thereof |
| CN101301081A (en) * | 2008-06-27 | 2008-11-12 | 西双版纳版纳药业有限责任公司 | Horseradish tree chawing tablet |
| CN101352449A (en) * | 2007-07-27 | 2009-01-28 | 杭州民生药业集团有限公司 | Vitamin orally disintegrating tablet and preparation method thereof |
| CN102579686A (en) * | 2011-12-06 | 2012-07-18 | 西安泰科迈医药科技有限公司 | Traditional Chinese medicine lozenge and preparing method thereof |
| CN102920780A (en) * | 2012-11-12 | 2013-02-13 | 沈阳信达信息科技有限公司 | Pseudo-ginseng lozenge |
| CN103202470A (en) * | 2013-04-25 | 2013-07-17 | 福建永生活力生物工程有限公司 | Health food for reducing blood sugar in auxiliary manner and preparation method of health food |
| CN103750329A (en) * | 2014-02-18 | 2014-04-30 | 云南众爱生物科技有限公司 | Buccal tablet comprising ginseng, maca and horseradish tree leaf and preparation method of buccal tablet |
-
2016
- 2016-11-08 CN CN201610977410.0A patent/CN106509894A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742743A (en) * | 2005-09-21 | 2006-03-08 | 重庆康刻尔制药有限公司 | Pseudo-ginseng saponin oral disintegration tablet and preparing method |
| CN101190263A (en) * | 2006-11-30 | 2008-06-04 | 四川宇妥藏药药业有限责任公司 | Rhubarb chewable tablets and preparation method and application thereof |
| CN101352449A (en) * | 2007-07-27 | 2009-01-28 | 杭州民生药业集团有限公司 | Vitamin orally disintegrating tablet and preparation method thereof |
| CN101301081A (en) * | 2008-06-27 | 2008-11-12 | 西双版纳版纳药业有限责任公司 | Horseradish tree chawing tablet |
| CN102579686A (en) * | 2011-12-06 | 2012-07-18 | 西安泰科迈医药科技有限公司 | Traditional Chinese medicine lozenge and preparing method thereof |
| CN102920780A (en) * | 2012-11-12 | 2013-02-13 | 沈阳信达信息科技有限公司 | Pseudo-ginseng lozenge |
| CN103202470A (en) * | 2013-04-25 | 2013-07-17 | 福建永生活力生物工程有限公司 | Health food for reducing blood sugar in auxiliary manner and preparation method of health food |
| CN103750329A (en) * | 2014-02-18 | 2014-04-30 | 云南众爱生物科技有限公司 | Buccal tablet comprising ginseng, maca and horseradish tree leaf and preparation method of buccal tablet |
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| CN107496477A (en) * | 2017-09-07 | 2017-12-22 | 文山华信三七股份有限公司 | A kind of sugar-free sanchi flower buccal tablet and its production technology |
| CN107772457A (en) * | 2017-09-28 | 2018-03-09 | 广西宜州市宜源桑杆菌业有限公司 | A kind of preparation method of Moringaceae tablet |
| CN108992584A (en) * | 2018-08-28 | 2018-12-14 | 云南奇妙七生物科技有限公司 | A kind of sanchi flower dendrobium nobile lozenge and its preparation process |
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