CN101129790A - Compound hippophae rhamnoides lozenge method of producing the same - Google Patents
Compound hippophae rhamnoides lozenge method of producing the same Download PDFInfo
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- CN101129790A CN101129790A CNA2007100500638A CN200710050063A CN101129790A CN 101129790 A CN101129790 A CN 101129790A CN A2007100500638 A CNA2007100500638 A CN A2007100500638A CN 200710050063 A CN200710050063 A CN 200710050063A CN 101129790 A CN101129790 A CN 101129790A
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- fructus
- fine powder
- citri sarcodactylis
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- fructus citri
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- 235000003145 Hippophae rhamnoides Nutrition 0.000 title claims abstract description 11
- 150000001875 compounds Chemical class 0.000 title claims abstract description 10
- 239000007937 lozenge Substances 0.000 title claims abstract description 10
- 240000000950 Hippophae rhamnoides Species 0.000 title claims abstract description 9
- 238000000034 method Methods 0.000 title abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 32
- 238000002156 mixing Methods 0.000 claims abstract description 31
- 241000229143 Hippophae Species 0.000 claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 238000002360 preparation method Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 241000208340 Araliaceae Species 0.000 claims description 31
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 31
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 31
- 235000008434 ginseng Nutrition 0.000 claims description 31
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 235000003935 Hippophae Nutrition 0.000 claims description 21
- 239000000706 filtrate Substances 0.000 claims description 20
- 239000008187 granular material Substances 0.000 claims description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 13
- 229940046011 buccal tablet Drugs 0.000 claims description 11
- 239000006189 buccal tablet Substances 0.000 claims description 11
- 239000004375 Dextrin Substances 0.000 claims description 10
- 229920001353 Dextrin Polymers 0.000 claims description 10
- 229920003081 Povidone K 30 Polymers 0.000 claims description 10
- 230000001476 alcoholic effect Effects 0.000 claims description 10
- 235000019425 dextrin Nutrition 0.000 claims description 10
- 235000019359 magnesium stearate Nutrition 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 5
- 230000003179 granulation Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 3
- 235000002555 Citrus medica var sarcodactylis Nutrition 0.000 abstract 3
- 240000007126 Citrus medica var. sarcodactylis Species 0.000 abstract 3
- 244000012254 Canarium album Species 0.000 abstract 2
- 235000009103 Canarium album Nutrition 0.000 abstract 2
- 241000756042 Polygonatum Species 0.000 abstract 2
- 235000008737 Polygonatum biflorum Nutrition 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 206010013786 Dry skin Diseases 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 5
- 235000013343 vitamin Nutrition 0.000 description 5
- 239000011782 vitamin Substances 0.000 description 5
- 229940088594 vitamin Drugs 0.000 description 5
- 150000003722 vitamin derivatives Chemical class 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 206010006326 Breath odour Diseases 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- 208000032139 Halitosis Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 235000013402 health food Nutrition 0.000 description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 206010043458 Thirst Diseases 0.000 description 2
- 239000005844 Thymol Substances 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
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- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
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- 229960000790 thymol Drugs 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
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- 239000013543 active substance Substances 0.000 description 1
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- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
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- 230000036772 blood pressure Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
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- 229930003836 cresol Natural products 0.000 description 1
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- 230000002526 effect on cardiovascular system Effects 0.000 description 1
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- 239000003172 expectorant agent Substances 0.000 description 1
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- 238000013467 fragmentation Methods 0.000 description 1
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- 239000003205 fragrance Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000012004 hematohidrosis Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
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- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Disclosed is a compound seabuckthorn fruit lozenge and process for preparation, wherein the raw materials of the active constituents include sea-buckthorn 45-65, fresh Chinese olive 10-30, finger citron 10-30 and fragrant solomonseal rhizome 5-10, and the preparing process consists of disintegrating finger citron into fine powders, grilling seabuckthorn fruit, Chinese olive and fragrant solomonseal rhizome with water, filtering, concentrating, drying, disintegrating, mixing with finger citron powders, granulating and tabletting.
Description
(1) technical field:
A kind of compound hippophae rhamnoides lozenge and preparation method thereof belongs to the human health food, particularly is the health food of raw material with the plant, and its preparation method.
(2) background technology:
Modern society, it is fewer and feweri that huge work and life stress make that people obtain time of the required nutrient substance of health, and people need obtain healthy required nutrient substance easily by market.At present, the health-care products on the market is a lot, but the subject matter that these health-care products exist is that to be used to prepare its active component raw material numerous, at least tens the flavor raw materials, at most tens the flavor raw materials, cause production routine many, the product cost height causes these health foods can not popularize in the crowd.
Investigation finds that in life, many people suffer from chronic pharyngitis, and lung-heat, and gastric heat is heavier, and the phenomenon of halitosis is arranged, and influences very much the image of oneself in doings, oneself also is difficult to be subjected to.
(3) summary of the invention:
The problem to be solved in the present invention be exactly provide a kind of at above deficiency and prepare that its active component raw material is few, that the reasonable science of material combination, vitamin content are abundant is a kind of specially at the halitosis chronic disease, the buccal lozenge type health food of relieving sore-throat by clearing away heat.Its technical scheme is as follows:
It mainly comprises the raw material of following weight parts:
Fructus Hippophae 45-65, Fructus chebulae immaturus 10-30, Fructus Citri Sarcodactylis ginseng 10--30, Rhizoma Polygonati Odorati 5-10.
In order to reach better effect, raw material of the present invention also comprises Folium Mori 5-10.
Preparation method of the present invention may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into 150-200 order fine powder;
2) Fructus Hippophae, Fructus chebulae immaturus, Rhizoma Polygonati Odorati are added 6--8 times of water gaging, decoct and extract 2-3 time, each 2-3 hour, filter, merging filtrate refilters, is 70 ℃～80 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20--1.25 under 0.08～0.1Mpa condition;
3) with above-mentioned extract dry, be ground into 150--200 order fine powder, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add dextrin 30-40 part mixing, granulate with the 5--10% alcoholic solution that contains 5--10% 30 POVIDONE K 30 BP/USP 30,30--40 ℃ dry 2--3 hour, citric acid adds 5-10 part, magnesium stearate 5-10 part mixing, is pressed into buccal tablet after the granulation.
If also with the Folium Mori combination, its preparation method is:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into fine powder;
2) Fructus Hippophae, Fructus chebulae immaturus, Rhizoma Polygonati Odorati, Folium Mori are added 6--8 times of water gaging, decoct and extract 23 times, each 2-3 hour, filter, merging filtrate refilters, is 70 ℃～80 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20--1.25 under 0.08～0.1Mpa condition;
3) with above-mentioned extract dry, be ground into 150--200 order fine powder, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add dextrin 30-40 part mixing, granulate with the 5--10% alcoholic solution that contains 5--10% 30 POVIDONE K 30 BP/USP 30,30--40 ℃ dry 2--3 hour, add citric acid 5-10 part, 5-10 magnesium stearate part mixing, be pressed into buccal tablet.
Be used for raw material Fructus Hippophae extract of the present invention and contain tens kinds of bioactive substances that human body is necessary, content is up to more than 100 milligrams in the per 100 gram Fructus Hippophaes of its vitamin, beta-carotene is more than 10 milligrams, and unsaturated fatty acid is greater than 90%, and wherein the content of SOD is four times of Radix Ginseng.The clinical discovery Fructus Hippophae extract is to people's cardiovascular and cerebrovascular vessel, digestion and immune system, and to enhancing metabolism, defying age, radioprotective, anticancer etc. all having a remarkable efficacy.Fructus chebulae immaturus contains cresol, thymol (thymol), vitamin C, limonene etc., and sweet in the mouth, acid have heat clearing away, and sore-throat relieving promotes the production of body fluid, detoxifcation.Be used for laryngopharynx swelling and pain,
Cough, disease such as excessive thirst, clearing away lung-heat.Fructus Citri Sarcodactylis ginseng, regulate the flow of vital energy and in, the effect of ending stomachache, clearing away stomach-heat.Rhizoma Polygonati Odorati, the flat sweet in the mouth of property has replenishing YIN and removing heat, an effect such as the cough-relieving of promoting the production of body fluid.Cure mainly diseases such as dryness of the mouth and throat, the few expectorant of dry cough, rheumatism cough, heating hematohidrosis, vexed cardiopalmus, calentura excessive thirst.Folium Mori, Compendium of Materia Medica " middle record: Folium Mori " juice is fried in shallow oil Dai Ming, can only quench one's thirst "; " the ripe drink of frying in shallow oil of moxibustion quenches the thirst for tea ".Cure house modern age and also often the Folium Mori compatibility was applied to clinically in Chinese medicine compound, and whenever obtained effect more.In recent years, various countries' research worker has been carried out systematic research to composition, function and the mechanism of action of Folium Mori, found that the aminoacid, cellulose, vitamin, mineral and the several physiological active substances that contain 17 kinds in the Folium Mori, have various health care functions such as blood sugar lowering, blood pressure lowering, blood fat reducing, slow down aging.The above five tastes match, and have the effect of promoting the production of body fluid for nourishing the lung, clear throat, heat-clearing and toxic substances removing, additional body vitamin.Can reach the elimination halitosis, the effect of fresh breath.
Advantage compared with prior art of the present invention is: prepare 1, that its active component raw material is natural, material combination rationally and science, vitamin content is very abundant, can reach the elimination halitosis, the effect of fresh breath. 2, production process is simple, has reduced production cost, is beneficial in the general population to popularize.3, product of the present invention does not contain sugar, and it is extensive to be suitable for the crowd.
(4) description of drawings:
Accompanying drawing is technological process of production figure of the present invention.
(5) specific embodiment:
Embodiment one:
Take by weighing each raw material by following weight proportion:
Fructus Hippophae 65, Fructus chebulae immaturus 20, Fructus Citri Sarcodactylis ginseng 10, Rhizoma Polygonati Odorati 5.
Its preparation method may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into 200 order fine powders;
2) Fructus Hippophae, Fructus chebulae immaturus, Rhizoma Polygonati Odorati are added 8 times of water gagings, decoct and extract 2 times, each 2.5 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 75 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.25 under the 0.1Mpa condition;
3) with above-mentioned extract dry, be ground into 200 order fine powders, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add 30 parts of mixings of dextrin, granulate, reclaim ethanol with 8% alcoholic solution that contains 8% 30 POVIDONE K 30 BP/USP 30,35 ℃ of dryings 2.5 hours, make moisture Control in the granule 3%～5%, add 6 parts of citric acid, 6 parts of mixings of magnesium stearate, be pressed into the buccal tablet that specification is the 600mg/ sheet.
The factor that influences tablet quality has pellet moisture, and the granule plasticity that water content is suitable is big, and the hardness and the degree of fragmentation of the tablet that is pressed into are better, and qualification rate is higher, and granule is too wet, and sticking then easily takes place.Pellet moisture should be controlled in 3%～5% better.When granulation, tabletting, storage, relative humidity should be controlled at below 55%, to reduce the influence of moisture pharmaceutical properties and stability.Product of the present invention should carry out packing in 100,000 grades of clean areas.
Product of the present invention is khaki buccal tablet, has Fructus Citri Sarcodactylis ginseng and the blended Chinese herbal medicine fragrance of other medicines, little acid of distinguishing the flavor of, promoting the production of body fluid to quench thirst.
Per 100 gram product vitamin C 〉=100mg.
Instructions of taking and dose: oral, every day 1--5 time, each 1.
Embodiment two:
Take by weighing each raw material by following weight proportion:
Fructus Hippophae 45, Fructus chebulae immaturus 30, Fructus Citri Sarcodactylis ginseng 25, Rhizoma Polygonati Odorati 8.
Its preparation method may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into 150 order fine powders;
2) Fructus Hippophae, Fructus chebulae immaturus are added 6 times of water gagings, decoct and extract 2 times, each 2 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 70 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20 under the 0.08Mpa condition;
3) with above-mentioned extract dry, be ground into 150 order fine powders, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add 25 parts of mixings of dextrin, granulate, reclaim ethanol with 5% alcoholic solution that contains 5% 30 POVIDONE K 30 BP/USP 30,30 ℃ of dryings 2 hours, make moisture Control in the granule 3%～5%, add 5 parts of citric acid, 5 parts of mixings of magnesium stearate, be pressed into buccal tablet after the granulation.
Embodiment three:
Take by weighing each raw material by following weight proportion:
Fructus Hippophae 55, Fructus chebulae immaturus 25, Fructus Citri Sarcodactylis ginseng 20, Rhizoma Polygonati Odorati 10.
Its preparation method may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into 180 order fine powders;
2) Fructus Hippophae, Fructus chebulae immaturus are added 8 times of water gagings, decoct and extract 3 times, each 3 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 80 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.25 under the 0.09Mpa condition;
3) with above-mentioned extract dry, be ground into 180 order fine powders, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add 40 parts of mixings of dextrin, granulate, reclaim ethanol with 10% alcoholic solution that contains 10% 30 POVIDONE K 30 BP/USP 30,40 ℃ of dryings 3 hours, make moisture Control in the granule 3%～5%, add 10 parts of citric acid, 10 parts of mixings of magnesium stearate, be pressed into buccal tablet.
Embodiment four:
Take by weighing each raw material by following weight proportion:
Fructus Hippophae 65, Fructus chebulae immaturus 15, Fructus Citri Sarcodactylis ginseng 15, Rhizoma Polygonati Odorati 5, Folium Mori 5.
Its preparation method may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into 200 order fine powders;
2) Fructus Hippophae, Fructus chebulae immaturus, Rhizoma Polygonati Odorati, Folium Mori are added 8 times of water gagings, decoct and extract 2 times, each 2.5 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 75 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.25 under the 0.1Mpa condition;
3) with above-mentioned extract dry, be ground into 200 order fine powders, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add 30 parts of mixings of dextrin, granulate, reclaim ethanol with 8% alcoholic solution that contains 8% 30 POVIDONE K 30 BP/USP 30,35 ℃ of dryings 2.5 hours, make moisture Control in the granule 3%～5%, add 6 parts of citric acid, 6 parts of mixings of calcium carbonate, be pressed into buccal tablet.
Embodiment five:
Take by weighing each raw material by following weight proportion:
Fructus Hippophae 45, Fructus chebulae immaturus 25, Fructus Citri Sarcodactylis ginseng 20, Rhizoma Polygonati Odorati 8, Folium Mori 8.
Its preparation method may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into 150 order fine powders;
2) Fructus Hippophae, Fructus chebulae immaturus, Rhizoma Polygonati Odorati, Folium Mori are added 6 times of water gagings, decoct and extract 2 times, each 2 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 70 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20 under the 0.08Mpa condition;
3) with above-mentioned extract dry, be ground into 150 order fine powders, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add dextrin 25 mixings, granulate, reclaim ethanol with 5% alcoholic solution that contains 5% 30 POVIDONE K 30 BP/USP 30,30 ℃ of dryings 2 hours, make moisture Control in the granule 3%～5%, add 5 parts of citric acid, 5 parts of mixings of calcium carbonate, be pressed into buccal tablet.
Embodiment six:
Take by weighing each raw material by following weight proportion:
Fructus Hippophae 55, Fructus chebulae immaturus 20, Fructus Citri Sarcodactylis ginseng 18, Rhizoma Polygonati Odorati 10, Folium Mori 10.
Its preparation method may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into 180 order fine powders;
2) Fructus Hippophae, Fructus chebulae immaturus, Rhizoma Polygonati Odorati, Folium Mori are added 8 times of water gagings, decoct and extract 3 times, each 3 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 80 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.25 under the 0.09Mpa condition;
3) with above-mentioned extract dry, be ground into 180 order fine powders, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add 40 parts of mixings of dextrin, granulate, reclaim ethanol with 10% alcoholic solution that contains 10% 30 POVIDONE K 30 BP/USP 30,40 ℃ of dryings 3 hours, make moisture Control in the granule 3%～5%, add 10 parts of citric acid, 10 parts of mixings of calcium carbonate, be pressed into buccal tablet.
Claims (5)
1. compound hippophae rhamnoides lozenge is characterized in that preparing the raw material that its active component raw material comprises following weight portion:
Fructus Hippophae 45-65, Fructus chebulae immaturus 10-30, Fructus Citri Sarcodactylis ginseng 10-30, Rhizoma Polygonati Odorati 5-10.
2. the preparation method of the described compound hippophae rhamnoides lozenge of claim 1 is characterized in that may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into fine powder;
2) Fructus Hippophae, Fructus chebulae immaturus, Rhizoma Polygonati Odorati are added 6--8 times of water gaging, decoct and extract 2-3 time, each 2-3 hour, filter, merging filtrate refilters, and filtrate is concentrated into the extractum of relative density 1.20--1.25;
3) with above-mentioned extract dry, be ground into fine powder, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add dextrin 30-40 part mixing, granulate with the 5--10% alcoholic solution that contains 5--10% 30 POVIDONE K 30 BP/USP 30,30--40 ℃ dry 2--3 hour, add citric acid 5-10 part, magnesium stearate 5-10 part mixing, after the granulation, be pressed into buccal tablet.
3. compound hippophae rhamnoides lozenge according to claim 1 is characterized in that wherein raw material also has Folium Mori 5-10 part.
4. the preparation method of compound hippophae rhamnoides lozenge according to claim 3 is characterized in that may further comprise the steps:
1) it is standby the Fructus Citri Sarcodactylis ginseng to be ground into fine powder;
2) Fructus Hippophae, Fructus chebulae immaturus, Rhizoma Polygonati Odorati, Folium Mori are added 6--8 times of water gaging, decoct and extract 2-3 time, each 2-3 hour, filter, merging filtrate refilters, and filtrate is concentrated into the extractum of relative density 1.20--1.25;
3) with above-mentioned extract dry, be ground into fine powder, with Fructus Citri Sarcodactylis ginseng fine powder mixing, add dextrin 30-40 part mixing, granulate with the 5--10% alcoholic solution that contains 5--10% 30 POVIDONE K 30 BP/USP 30,30--40 ℃ dry 2--3 hour, add citric acid 5-10 part, magnesium stearate 5-10 part mixing, be pressed into buccal tablet after the granulation.
5. according to the preparation method of claim 2 or 4 described compound hippophae rhamnoides lozenges, it is characterized in that the condition of concentrated extract is: temperature is 70 ℃～80 ℃, and vacuum is 0.08～0.1Mpa.
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| CN103844263A (en) * | 2014-02-11 | 2014-06-11 | 毛庆云 | Buccal tablet for treating ozostomia and preparation method thereof |
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| CN108157858A (en) * | 2017-12-25 | 2018-06-15 | 大连民族大学 | A kind of compound lozenge of fructus hippophae leaf |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103844263A (en) * | 2014-02-11 | 2014-06-11 | 毛庆云 | Buccal tablet for treating ozostomia and preparation method thereof |
| CN104586677A (en) * | 2014-10-19 | 2015-05-06 | 威海北玮贸易有限公司 | Gargle for removing oral cavity peculiar smell |
| CN107007739A (en) * | 2016-01-28 | 2017-08-04 | 四川省中医药科学院 | Improve or the scorching composition of therapeutic radiation oropharyngeal mucosae and preparation method and application |
| CN107007739B (en) * | 2016-01-28 | 2020-08-11 | 四川省中医药科学院 | Composition for improving or treating radiation oropharyngeal mucositis and preparation method and application thereof |
| CN106071626A (en) * | 2016-06-26 | 2016-11-09 | 明毅强 | A kind of processing method of Fructus chebulae immaturus Fructus Hippophae decoction pieces |
| CN106727007A (en) * | 2017-01-02 | 2017-05-31 | 李大兴 | A kind of sea-buckthorn anti-aging toothpaste |
| CN108157858A (en) * | 2017-12-25 | 2018-06-15 | 大连民族大学 | A kind of compound lozenge of fructus hippophae leaf |
| CN108858549A (en) * | 2018-07-02 | 2018-11-23 | 福建省将乐好家园木业有限公司 | A kind of round bamboo asphalt scraping device |
| WO2022041664A1 (en) * | 2020-08-25 | 2022-03-03 | 杭州国光药业股份有限公司 | Color modifier, lysozyme lozenge, and method for preparing lysozyme lozenge |
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| CN100542584C (en) | 2009-09-23 |
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Assignee: Chengdu Shenghongyuan Science & Trading Co., Ltd. Assignor: Xie Jiangli Contract fulfillment period: 2009.10.11 to 2019.10.10 Contract record no.: 2009510000165 Denomination of invention: Compound hippophae rhamnoides lozenge method of producing the same Granted publication date: 20090923 License type: Exclusive license Record date: 20091123 |
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